Hub : Genes

C3orf57

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0180 0.0121 0.0015 0.011 0.007 0.004 NA 0.003 0.0022 0.01100 0.0460 NA 0.0560
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0247 0.0142 0.0022 0.023 0.027 0.019 NA 0.020 0.0011 0.00045 0.0027 NA 0.0023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.2 0.0
Bipolar Disorder or Schizophrenia 1.4 3.4 5.2 1.3 -2.3
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 -0.9 -0.1
Depression (Nagel 2018) 0.1 0.2 0.3 0.0 -0.6
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.6 -0.8 -0.2
Neuroticism (Nagel 2018) 0.5 1.1 2.3 -0.1 -1.5
Schizophrenia (2018) 2.9 6.0 8.8 1.8 -3.0
Schizophrenia vs Biploar Disorder 5.2 6.8 9.5 2.1 -3.1
Worry (Nagel 2018) 0.7 1.5 3.1 -1.8 -0.0
Alzheimer’s Disease (in mother) 2.0 2.3 3.6 -1.0 1.9
Alzheimer’s Disease (in father) 3.0 3.2 3.8 -1.6 2.0
Alzheimer’s Disease (including proxy) 2.1 3.0 4.3 -1.3 2.1
Crohns Disease (2017) 0.3 0.8 1.4 0.4 -1.2
Irritable Bowel Disease (IBD) 0.2 0.4 0.5 -0.5 0.7
Ulcerative Colitis (UC) 1.9 3.5 5.5 -1.3 2.3
Major Depression (MDD) 0.3 0.3 0.5 -0.7 -0.4
Reaction Time 0.3 0.6 1.1 1.0 -0.4
Verbal and Numeric Reasoning (VNR) 1.1 2.5 4.3 -2.1 0.9
Breast Cancer 0.4 0.9 1.6 1.3 -0.4
Ovarian Cancer 2.8 3.7 3.7 1.9 -1.9
Prostate Cancer 0.2 0.2 0.4 0.3 0.6
Age at First Birth 0.5 0.7 1.2 0.4 -1.1
Bipolar Disorder (2011) 4.9 4.8 6.6 1.7 -2.6
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 1.2 -0.2
Coronary Artery Disease (CAD) 2.7 3.2 3.6 1.9 -1.7
Crohns Disease (2012) 0.8 1.3 2.3 0.6 -1.5
Mean Putamen Volume 1.7 1.9 2.3 1.5 -1.2
Fasting Glucose 0.3 0.3 0.5 -0.7 -0.3
HbA1C 0.3 0.3 0.6 -0.2 -0.8
HDL Cholesterol 0.4 0.7 1.3 0.4 -1.1
LDL Cholesterol 0.3 0.5 1.0 -1.0 0.1
Lupus 0.0 0.0 0.1 -0.2 -0.1
Neuroticism (2016) 0.3 0.5 0.7 0.5 0.8
Primary Biliary Cirrhosis 1.0 1.5 2.0 -1.4 1.0
Rheumatoid Arthritis 1.0 1.4 1.7 -1.3 1.1
Schizophrenia (2014) 5.2 11.4 14.7 2.8 -3.8
Triglycerides 0.2 0.3 0.5 -0.1 -0.7
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.4 -0.3 0.7
Ulcerative Colitis 1.6 2.3 2.3 -1.5 1.5
Blood Eosinophil Count 0.6 4.4 4.7 2.2 -2.0
Blood Platelet Count 0.0 0.4 0.6 -0.5 0.8
Blood Red Count 0.6 5.5 7.1 -2.0 2.7
Blood White Count 0.0 0.1 0.2 -0.5 -0.2
Heel T-Score 0.2 1.6 3.1 1.8 -0.2
BMI 0.2 0.9 1.7 0.2 1.3
Height 0.2 3.1 4.6 -1.2 2.1
Waist Hip Ratio (WHR) 1.3 5.8 10.3 -1.1 3.2
Systolic Blood Pressure 4.2 21.2 36.5 -6.0 2.4
Smoking Status 1.5 3.6 4.7 1.6 -2.2
Allergy or Eczema 0.3 0.8 1.4 -0.4 1.2
Cardiovascular Disease 2.1 7.0 10.5 -3.2 1.9
Hypothyroidism (self reported) 0.3 0.6 1.2 -1.1 -0.2
Respiratory disease 2.1 4.8 6.9 -1.6 2.6
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.2 0.4 -0.4
Lung FEV1/FVC ratio 0.2 1.3 1.3 -1.1 -1.1
Lung FVC 0.1 0.4 0.7 0.8 -0.4
Neuroticism 0.4 1.1 1.8 -0.5 -1.3
Chronotype (morning person) 5.7 13.2 21.0 2.3 -4.6
Hair Pigment 0.0 0.4 0.7 0.8 -0.2
Tanning 0.1 1.3 2.5 0.4 -1.6
Hand grip strength (left) 1.6 4.2 8.3 0.5 -2.9
Number of treatments/medications taken 4.6 8.3 11.7 -3.4 2.2
Average weekly spirits intake 1.6 2.0 3.9 0.3 2.0
Sensitivity / hurt feelings 1.1 1.9 2.1 1.4 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.7 -0.2
Hearing difficulty/problems: Yes 3.3 5.0 6.0 -2.5 2.0
Relative age of first facial hair 0.3 0.7 0.9 0.6 -0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 0.7 -0.7 0.8
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.9 -0.9 0.2
Ever had hysterectomy (womb removed) 5.3 6.0 10.4 -3.2 1.2
Systolic blood pressure, automated reading 4.3 12.5 18.3 -4.3 2.6
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 3.4 0.8 -1.8
Angina 0.2 0.3 0.6 0.8 -0.2
Medication for hormone replacement therapy 0.0 0.0 0.0 0.1 0.2
Vitamin and mineral supplements 2.6 3.6 5.9 1.1 -2.4
Supplements: Zinc 0.3 0.3 0.4 -0.5 0.7
Medication: Co-codamol 0.4 0.4 0.9 -0.2 0.9
Medication: Metformin 0.7 1.0 1.9 -1.4 0.1
Diabetes (father) 0.5 0.6 1.2 0.2 1.1
Diabetes (mother) 0.1 0.2 0.3 -0.6 0.1
Severe depression (siblings) 0.2 0.2 0.4 -0.6 -0.3
Pack years adult smoking proportion 0.3 0.4 0.8 0.3 0.9
Impedance of leg (right) 0.2 1.2 1.6 -1.3 0.9
Leg fat-free mass (left) 0.2 0.9 1.8 -0.3 1.3
Trunk fat percentage 0.2 0.6 1.2 -0.0 1.1
Hand grip strength (right) 0.4 1.2 2.4 -0.1 -1.6
Townsend deprivation index at recruitment 0.5 0.7 1.2 -0.4 1.1
Current tobacco smoking 1.0 1.7 3.0 1.7 -0.5
Average weekly fortified wine intake 0.5 0.5 0.8 0.5 -0.9
Maternal smoking around birth 1.1 1.7 2.9 -1.7 -0.7
Fed-up feelings 0.4 0.7 1.4 -1.2 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 0.7 0.0
Relative age voice broke 0.2 0.2 0.5 0.1 -0.7
Taking other prescription medications 0.4 0.7 1.0 -1.0 0.6
Age when periods started (menarche) 0.3 0.8 1.7 -0.1 -1.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.3 -1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.1 0.3 0.1
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 2.3 1.5 0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.5 -0.1
Serious illness, injury or assault to yourself 0.8 1.0 1.3 -0.8 -1.2
High blood pressure 1.5 4.3 6.0 -2.4 1.6
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.6 -0.6 1.9
Multivitamins +/- minerals 1.4 1.8 2.6 -1.0 1.6
Stomach or abdominal pain in last month 0.9 1.2 2.3 1.5 -0.1
Supplements: Glucosamine 0.2 0.3 0.4 0.6 -0.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.9 -0.6 -1.0
Medication: Atenolol 0.4 0.5 0.9 0.1 -1.0
Medication: Levothyroxine sodium 0.6 1.1 1.7 -0.7 1.3
Sitting height 0.1 0.5 0.9 -0.9 0.5
Chronic bronchitis/emphysema (father) 0.4 0.5 1.0 -0.0 -1.0
High blood pressure (mother) 4.7 6.6 7.8 -2.3 2.8
Body mass index (BMI) 0.3 1.1 2.2 -0.3 1.5
Impedance of leg (left) 0.2 0.9 1.4 -1.2 0.7
Leg predicted mass (left) 0.2 0.9 1.8 -0.2 1.3
Trunk fat mass 0.3 1.4 2.5 -0.5 1.6
Waist circumference 0.9 3.3 5.6 -1.0 2.4
Number of incorrect matches in round 0.9 1.4 2.6 -0.6 -1.6
Past tobacco smoking 1.3 2.3 4.2 -0.7 2.0
Alcohol usually taken with meals 0.0 0.1 0.1 0.4 -0.0
Nervous feelings 1.3 2.4 4.3 -2.1 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.9 -1.7 0.6
Hearing difficulty/problems with background noise 0.1 0.2 0.2 0.5 0.4
Hair/balding pattern: Pattern 2 0.3 0.3 0.7 0.8 0.1
Had menopause 0.5 0.6 0.7 -0.8 0.7
Had other major operations 0.8 0.9 1.1 1.1 -0.9
Forced vital capacity (FVC) 0.3 1.0 1.5 -1.2 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.1 0.0 0.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 -0.3 1.0
Qualifications: None of the above 1.4 3.0 5.3 -2.3 0.8
Financial difficulties in last 2 years 0.3 0.4 0.5 -0.6 0.7
Mouth/teeth dental problems 1.8 2.8 3.5 1.4 -1.9
Heart attack 0.1 0.1 0.2 0.4 -0.2
Allergy 2.1 4.9 6.4 1.9 -2.5
Pain all over the body in last month 0.5 0.5 0.8 -0.9 0.5
Diabetes (self-reported) 0.5 0.7 1.3 -0.4 -1.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.0 -0.8 1.4
Medication: Ramipril 0.5 0.6 1.3 0.1 1.1
Medication: Simvastatin 0.2 0.3 0.5 -0.7 0.3
Fluid intelligence score 1.5 3.0 3.4 -1.8 1.6
Illnesses of siblings 3.3 4.6 6.9 2.6 -1.5
Neuroticism score 0.2 0.5 0.9 -0.9 -0.4
Weight 0.5 2.4 4.0 -0.9 2.0
Impedance of arm (right) 0.2 0.8 1.2 0.7 -1.1
Arm fat percentage (right) 0.1 0.5 0.9 -0.0 1.0
Trunk fat-free mass 0.5 2.9 3.6 -1.5 1.9
Hip circumference 0.2 0.9 1.8 -0.1 1.3
Time employed in main current job 1.4 1.6 2.2 1.0 -1.5
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.8 -0.3
Father’s age at death 0.5 0.7 0.7 -0.8 0.8
Worrier / anxious feelings 0.2 0.4 0.6 0.8 -0.4
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 6.4 -1.1 2.5
Falls in the last year 0.5 0.7 1.1 1.1 0.6
Hair/balding pattern: Pattern 3 0.3 0.4 0.7 0.1 -0.9
Number of live births 0.2 0.2 0.3 0.5 -0.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 4.5 -2.1 1.7
Pulse rate 0.4 0.7 1.4 -0.2 1.2
Happiness 0.3 0.4 0.4 -0.6 -0.6
Noisy workplace 0.0 0.1 0.1 0.3 0.2
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.7 1.6 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 -0.8 -0.3
Mouth/teeth dental problems: Dentures 0.8 1.4 2.0 -1.4 0.9
Asthma 3.0 5.8 7.4 -2.7 2.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.2 0.5 -0.5
Medication: Cholesterol lowering 0.5 0.8 1.3 -0.5 1.1
Depression (self-reported) 0.2 0.2 0.3 -0.2 0.6
Medication: Lansoprazole 0.6 0.6 1.3 0.1 -1.1
Prospective memory result 1.1 1.4 1.7 1.0 -1.3
Lung cancer (father) 0.2 0.2 0.4 -0.3 -0.6
Illnesses of mother 4.7 5.8 5.9 2.4 -2.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 0.5 -0.7 0.7
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 -0.1 -0.2
Impedance of arm (left) 0.2 0.9 1.4 0.6 -1.2
Arm fat mass (right) 0.3 1.4 2.7 -0.4 1.6
Trunk predicted mass 0.5 3.0 3.8 -1.5 2.0
Standing height 0.2 2.3 2.7 -1.6 1.4
Length of working week for main job 1.2 1.3 2.3 0.6 1.5
Exposure to tobacco smoke at home 0.9 1.0 1.9 -0.1 -1.4
Breastfed as a baby 0.9 1.1 1.7 0.8 1.3
Tense / ‘highly strung’ 0.7 1.2 2.4 -1.6 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.3 4.5 -2.1 1.4
Hair/balding pattern: Pattern 4 1.0 2.5 3.1 -1.8 1.4
Birth weight of first child 0.2 0.3 0.5 -0.7 0.2
Peak expiratory flow (PEF) 4.6 10.7 12.4 -3.0 3.5
Pulse wave reflection index 2.1 2.6 2.7 1.6 -1.6
Ever highly irritable/argumentative for 2 days 0.9 1.0 1.5 -1.2 0.7
Loud music exposure frequency 0.6 0.7 1.2 -1.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 0.5 0.7 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 0.7 -0.7 0.9
Blood clot in the leg (DVT) 0.3 0.4 0.7 0.2 -0.8
Medication: Paracetamol 2.9 4.7 7.8 -2.8 1.3
Headache pain in last month 0.4 0.7 1.3 -0.3 1.1
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 3.6 1.9 -1.3
Glaucoma (self-reported) 2.2 2.6 4.0 1.1 -2.0
Gout (self-reported) 0.1 0.1 0.3 -0.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 -0.1 -0.1
Medication: Amlodipine 0.8 1.2 2.3 -1.5 -0.0
Medication: Ventolin 100micrograms inhaler 2.8 3.6 4.9 -1.5 2.2
Birth weight 0.4 0.9 1.2 1.1 0.7
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.4 -0.4
High blood pressure (siblings) 3.6 5.2 6.0 -2.5 2.1
Forced vital capacity (FVC), Best measure 0.0 0.0 0.1 0.0 0.3
Body fat percentage 0.2 0.8 1.7 -0.1 1.3
Leg fat percentage (right) 0.8 3.0 4.8 -1.1 2.2
Arm fat-free mass (right) 0.7 3.4 4.8 -1.4 2.2
Exposure to tobacco smoke outside home 2.9 3.9 4.1 -2.0 1.9
Comparative body size at age 10 0.2 0.7 1.0 1.0 0.6
Number of full brothers 0.4 0.5 0.6 -0.8 0.6
Worry too long after embarrassment 2.9 4.9 7.2 1.6 -2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 2.6 -0.8 1.6
Wheeze or whistling in the chest in last year 3.5 6.2 7.7 -2.2 2.8
Number of children fathered 0.1 0.2 0.2 0.3 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.0 0.3 -1.4
Age at first live birth 1.8 3.2 3.4 1.8 -1.8
Pulse wave peak to peak time 0.1 0.1 0.1 -0.3 0.3
Health satisfaction 0.2 0.2 0.4 0.3 0.6
Shortness of breath walking on level ground 0.3 0.3 0.4 0.6 0.5
Qualifications: College or University degree 1.3 4.0 6.1 2.5 -1.4
Eye problems/disorders: None of the above 1.1 1.2 1.5 -1.0 1.2
Mouth/teeth dental problems: Loose teeth 3.8 4.5 6.0 2.5 -1.8
Emphysema/chronic bronchitis 1.0 1.2 2.0 -0.6 1.4
Medication for pain relief, constipation, heartburn 0.4 0.7 1.3 1.1 0.1
Neck or shoulder pain in last month 1.4 1.9 3.0 -0.9 1.7
Medication: Blood pressure 1.5 2.6 4.6 -2.2 0.8
Angina (self-reported) 0.2 0.2 0.5 0.7 -0.0
Migraine (self-reported) 0.1 0.2 0.3 0.3 0.5
Medication: Ibuprofen 0.0 0.0 0.0 0.2 0.0
Medication: Allopurinol 0.0 0.0 0.0 0.1 0.2
Medication: Omeprazole 0.5 0.6 1.0 -0.5 -1.0
Medication: Seretide 50 evohaler 1.7 2.0 2.2 -1.3 1.5
Mean time to correctly identify matches 0.4 0.8 1.3 1.1 -0.5
Heart disease (mother) 2.6 3.2 4.0 -1.5 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.1 -1.0 -0.5
Whole body fat mass 0.4 1.8 3.2 -0.6 1.8
Leg fat mass (right) 0.6 2.5 4.3 -0.9 2.1
Arm predicted mass (right) 0.4 2.0 3.1 -1.0 1.8
Pulse rate, automated reading 2.8 9.2 13.4 -2.2 3.7
Alcohol intake frequency. 4.2 9.7 12.5 -3.5 2.6
Comparative height size at age 10 0.1 0.7 1.1 -1.1 0.6
Number of full sisters 0.1 0.1 0.2 0.4 0.4
Suffer from ‘nerves’ 3.9 6.1 8.8 -3.0 1.9
Overall health rating 3.5 7.6 9.6 -2.4 3.1
Chest pain or discomfort 1.6 2.3 2.6 -1.4 1.6
Had major operations 0.1 0.2 0.3 -0.2 0.5
Age at last live birth 3.5 5.0 5.5 2.3 -2.2
Family relationship satisfaction 0.2 0.2 0.4 -0.0 -0.7
Leg pain on walking 0.8 1.1 1.1 -1.0 1.0
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 3.6 -1.9 1.5
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.6 -0.3 1.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 2.9 1.7 -0.8
Medication: Aspirin 0.8 1.0 1.1 1.0 -1.0
Supplements: Vitamin C 1.1 1.3 2.5 -0.4 1.6
Knee pain experienced in last month 0.2 0.3 0.4 -0.4 0.7
Hypertension (Self-reported) 1.3 3.7 5.5 -2.3 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 1.4 1.0 -1.2
Illnesses of father: Heart disease 0.4 0.6 0.7 -0.7 0.8
Illnesses of siblings: Diabetes 5.6 6.9 7.3 -2.5 2.7
Smoking status: Previous 0.5 0.7 1.0 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.0 -0.9 1.4
Whole body fat-free mass 0.3 1.8 2.9 -0.9 1.7
Leg fat-free mass (right) 0.1 0.5 1.0 -0.1 1.0
Arm fat percentage (left) 0.1 0.4 0.7 0.2 0.9
Average weekly red wine intake 2.2 3.3 5.6 1.0 -2.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 2.4 -1.1 1.5
Mood swings 0.3 0.6 0.6 -0.8 -0.7
Loneliness, isolation 0.1 0.1 0.1 -0.3 0.3
Long-standing illness, disability or infirmity 3.0 4.6 6.4 -1.7 2.5
Ever had bowel cancer screening 1.0 1.1 2.3 -1.5 0.1
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.2 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 0.3 0.5
Friendships satisfaction 0.1 0.2 0.3 -0.1 -0.6
Qualifications: nursing, teaching 0.4 0.6 0.8 0.6 0.9
Commuting to job workplace: Walk 3.5 3.8 3.9 -1.9 2.0
Eye problems/disorders: Cataract 0.0 0.0 0.0 0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.1 1.1 0.8
Medication for cholesterol 0.4 0.7 1.3 1.1 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 1.2 -0.3
Back pain experienced in last month 2.3 3.3 4.0 -2.0 1.6
Mineral and other dietary supplements 0.2 0.3 0.6 0.2 0.8
Breast cancer (self-reported) 0.0 0.0 0.1 0.1 -0.2
Asthma (self-reported) 2.7 5.3 7.0 -2.6 1.9
Osteoporosis (self-reported) 2.1 2.6 2.9 -1.5 1.7
Osteoarthritis (self-reported) 2.1 2.7 3.1 1.5 -1.8
Medication: Aspirin 0.8 1.0 1.3 0.8 -1.2
Medication: Gliclazide 0.1 0.1 0.2 0.1 0.4
Illnesses of father: None of the above (group 1) 0.6 0.8 1.1 0.7 -1.1
Smoking status: Current 2.3 3.6 5.4 2.3 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.4 -0.3
Whole body water mass 0.3 2.0 3.1 -1.0 1.7
Leg predicted mass (right) 0.1 0.5 0.9 -0.1 1.0
Arm fat mass (left) 0.3 1.3 2.4 -0.3 1.6
Number of self-reported non-cancer illnesses 2.4 4.2 5.3 -2.3 1.8
Average weekly champagne plus white wine intake 2.1 3.0 4.2 2.0 -1.3
Miserableness 0.7 1.2 1.7 -0.8 1.3
Guilty feelings 3.6 5.5 7.9 1.8 -2.8
Wears glasses or contact lenses 0.5 0.6 1.0 -1.0 -0.5
Ever taken oral contraceptive pill 0.6 0.7 1.3 1.1 -0.2
Hearing aid user 1.3 1.5 2.9 -1.7 0.1
Mother’s age at death 0.3 0.4 0.6 0.5 0.7
Financial situation satisfaction 0.9 1.1 1.3 -1.0 1.1
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.4 -0.8 1.2
Commuting to job workplace: Public transport 0.5 0.6 0.8 0.9 -0.6
Eye problems/disorders: Glaucoma 0.8 0.9 1.8 -0.1 -1.3
Medication: Blood pressure 0.2 0.4 0.7 -0.9 -0.0
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.4 0.1 0.6
Supplements: Fish oil (including cod liver oil) 0.7 1.0 1.9 -1.4 0.1
High cholesterol (Self-reported) 1.5 2.6 4.3 -2.1 1.0
Medication: Bendroflumethiazide 0.4 0.6 0.6 -0.7 0.8
Medication: Paracetamol 5.1 7.9 12.2 -3.5 1.9
Medication: Lisinopril 0.1 0.1 0.2 0.5 0.2
Medication: Atorvastatin 0.5 0.6 1.0 -1.0 0.4
Illnesses of father: High blood pressure 0.8 1.0 1.4 0.7 -1.2
Alcohol drinker status: Never 0.1 0.1 0.3 -0.5 0.0
Ever smoked 2.7 4.8 6.8 1.7 -2.6
Basal metabolic rate 0.4 2.2 3.5 -0.9 1.9
Leg fat percentage (left) 0.6 2.3 3.9 -0.8 2.0
Arm fat-free mass (left) 0.6 3.1 4.8 -1.2 2.2
Number of operations (self-reported) 0.4 0.5 1.0 1.0 -0.3
Average weekly beer plus cider intake 1.3 1.9 3.7 1.9 -0.4
Irritability 0.4 0.7 1.2 -1.1 -0.5
Risk taking 2.6 3.8 6.6 1.0 -2.6
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 -0.3 -0.7
Fractured/broken bones in last 5 years 0.7 0.8 1.2 -0.7 -1.1
Age started oral contraceptive pill 0.7 0.9 1.6 0.5 -1.3
Diastolic blood pressure, automated reading 2.7 8.5 10.6 -3.3 2.5
Ever depressed for a whole week 0.7 0.8 0.9 -1.0 0.8
Unable to work because of sickness or disability 0.1 0.2 0.3 0.2 0.6
Commuting to job workplace: Cycle 8.5 10.3 13.9 2.6 -3.7
Myopia 1.2 1.7 1.8 1.4 -1.2
Vascular/heart problems diagnosed by doctor 0.8 2.3 2.8 1.7 -1.3
Cholesterol lowering medication 0.9 1.3 2.5 -1.6 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.3 -0.4 -1.1
Pain experienced in last month 0.0 0.1 0.2 0.4 -0.1
Supplements: Calcium 0.2 0.2 0.4 0.6 0.4
Basal cell carcinoma (self-reported) 0.4 0.4 0.5 0.7 0.6
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 0.3 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 -0.2 -0.6
Heart disease (siblings) 0.1 0.2 0.3 0.2 -0.6
Alcohol drinker status: Previous 1.5 1.7 1.9 -1.4 1.2
Pack years of smoking 0.2 0.3 0.5 0.1 0.7
Impedance of whole body 0.0 0.1 0.3 -0.0 -0.5
Leg fat mass (left) 0.6 2.2 3.9 -0.7 2.0
Arm predicted mass (left) 0.6 2.9 4.5 -1.2 2.1