Hub : Genes

C5orf51

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0310	0.0160	0.00074	0.031	0.020	0.024	0.023	0.027	9.3e-05	0.0015	0.00058	0.00067	0.0003
2	ROSMAP	Brain Pre-frontal Cortex	0.0337	0.0196	0.00130	0.005	0.016	0.005	0.018	0.006	5.9e-02	0.0030	0.06600	0.00190	0.0440
3	TCGA	Bladder Urothelial Carcinoma	0.0580	0.0420	0.00047	0.005	0.024	0.023	NA	0.010	1.0e-01	0.0036	0.00440	NA	0.0430
4	TCGA	Brain Lower Grade Glioma	0.0159	0.0114	0.00800	0.012	0.002	0.002	NA	0.006	1.3e-02	0.1900	0.18000	NA	0.0590
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.2470	0.1080	0.00075	0.001	-0.004	-0.004	NA	-0.002	2.6e-01	0.7000	0.70000	NA	0.4300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.3	2.0	2.5	1.6	1.6	-1.2	1.4	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	1.2	1.2	-0.1	0.5	-0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.1	0.5	-0.5	0.6
Depression (Nagel 2018)	0.1	0.2	0.5	0.2	0.7	-0.0	0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.7	1.6	0.7	-1.5	1.5	-1.6
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.5	0.1	0.8	-0.6	0.4
Schizophrenia (2018)	0.1	0.2	0.8	0.3	0.3	0.9	-0.4	0.3
Schizophrenia vs Biploar Disorder	1.9	2.5	3.2	-1.5	-1.6	1.3	-1.7	1.8
Worry (Nagel 2018)	0.3	0.6	1.7	-0.6	-0.2	1.3	-0.9	0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	-0.4	-0.2	0.8	-0.5	0.4
Alzheimer’s Disease (in father)	0.6	0.6	2.3	0.2	1.5	-0.4	0.4	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.5	0.3	0.6	-0.5	0.4
Crohns Disease (2017)	3.1	6.8	10.4	2.5	3.2	-1.9	2.6	-2.6
Irritable Bowel Disease (IBD)	1.6	3.7	6.5	1.7	2.5	-1.1	1.8	-2.1
Ulcerative Colitis (UC)	0.3	0.5	1.0	0.6	0.7	-0.2	0.7	-1.0
Major Depression (MDD)	2.4	2.9	6.6	1.2	1.9	-0.5	1.6	-2.6
Reaction Time	0.6	1.2	2.6	1.1	1.6	-0.5	0.8	-1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.5	1.2	0.7	-1.1	1.1	-1.2
Breast Cancer	0.0	0.1	0.2	-0.1	0.4	-0.3	-0.1	0.5
Ovarian Cancer	1.4	1.9	2.2	-1.2	-1.4	1.4	-1.5	1.4
Prostate Cancer	0.6	0.8	1.3	-1.0	-1.2	0.0	-0.6	1.1
Age at First Birth	2.3	3.4	8.4	-1.7	-2.9	0.9	-1.4	1.7
Bipolar Disorder (2011)	0.4	0.4	0.9	0.5	0.9	-0.0	0.4	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	0.0	1.2	0.5	0.0	-0.4
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.6	-0.1	-0.4	0.3	-0.5
Crohns Disease (2012)	3.3	5.4	7.2	2.4	2.7	-1.8	2.4	-2.1
Mean Putamen Volume	0.3	0.3	0.7	-0.5	0.1	0.3	-0.7	0.8
Fasting Glucose	0.6	0.8	1.5	-1.0	-0.4	0.9	-1.2	0.6
HbA1C	2.9	3.2	4.7	-1.9	-2.0	1.4	-2.2	1.4
HDL Cholesterol	0.1	0.1	0.2	0.1	0.5	0.2	-0.3	-0.3
LDL Cholesterol	0.2	0.4	0.9	0.7	0.4	-0.9	0.5	-0.1
Lupus	1.5	2.3	2.7	-1.4	-1.6	1.6	-1.5	1.5
Neuroticism (2016)	0.3	0.5	1.3	-1.1	-0.3	0.7	-0.6	0.4
Primary Biliary Cirrhosis	0.5	0.8	1.4	1.2	0.5	-0.9	0.9	-0.7
Rheumatoid Arthritis	0.2	0.3	0.7	0.8	0.5	-0.5	0.5	-0.5
Schizophrenia (2014)	0.1	0.3	0.5	-0.1	-0.2	0.7	-0.7	0.7
Triglycerides	0.1	0.1	0.3	-0.3	-0.5	-0.1	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.8	-0.9	-0.8	0.4	-0.8	0.8
Ulcerative Colitis	0.8	1.2	1.5	1.1	1.2	-0.8	1.0	-1.1
Blood Eosinophil Count	0.0	0.2	0.7	0.1	0.9	0.4	0.1	-0.4
Blood Platelet Count	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	0.2
Blood Red Count	0.3	3.3	7.2	-1.4	-2.7	-0.1	-1.1	2.5
Blood White Count	0.1	0.6	1.0	-0.8	-0.4	1.0	-0.7	0.7
Heel T-Score	1.5	11.6	31.9	-1.7	-5.7	-1.0	-1.8	4.4
BMI	0.1	0.6	1.3	-0.8	0.5	1.1	-0.7	-0.0
Height	2.2	42.0	49.2	6.8	6.9	-5.0	6.5	-7.0
Waist Hip Ratio (WHR)	0.3	1.3	2.2	-0.9	-1.5	1.3	-1.1	0.7
Systolic Blood Pressure	0.0	0.2	0.6	0.2	0.8	-0.2	0.3	-0.2
Smoking Status	0.1	0.3	0.7	0.6	0.8	0.0	0.3	-0.3
Allergy or Eczema	1.5	4.0	5.6	2.0	1.9	-1.5	2.2	-2.4
Cardiovascular Disease	0.8	2.8	5.0	1.5	2.2	-0.6	1.5	-2.0
Hypothyroidism (self reported)	0.0	0.1	0.3	-0.1	0.1	0.5	-0.1	-0.5
Respiratory disease	0.3	0.7	2.3	-0.5	1.5	0.8	0.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.1	1.5	0.8	-1.1	1.3	-0.8
Lung FEV1/FVC ratio	0.8	4.1	6.7	-1.9	-2.6	1.0	-2.0	2.4
Lung FVC	0.1	0.6	1.5	-0.4	-1.2	-0.1	-0.4	1.2
Neuroticism	0.1	0.2	0.5	-0.4	0.0	0.7	-0.4	0.3
Chronotype (morning person)	1.9	4.4	7.6	-1.7	-2.8	1.0	-1.8	2.7
Hair Pigment	0.1	2.0	3.1	-1.2	-1.5	1.0	-1.5	1.8
Tanning	0.3	3.8	6.6	2.1	1.3	-2.6	2.1	-1.4
Hand grip strength (left)	0.5	1.4	2.5	-1.4	-0.5	1.6	-1.3	0.9
Number of treatments/medications taken	0.2	0.4	0.8	0.1	0.8	0.5	0.3	-0.9
Average weekly spirits intake	0.6	0.7	1.9	0.6	1.4	0.3	0.5	-1.0
Sensitivity / hurt feelings	0.1	0.1	0.6	-0.2	0.8	0.3	-0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.5	-0.2	0.7	0.0	-0.1	0.2
Hearing difficulty/problems: Yes	0.8	1.2	2.7	1.0	0.7	-1.7	1.1	-0.7
Relative age of first facial hair	2.1	4.4	6.9	-2.0	-1.6	1.8	-2.3	2.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.1	0.7	1.0	-0.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.3	-0.3
Ever had hysterectomy (womb removed)	2.6	3.0	4.0	1.9	1.8	-1.0	1.7	-2.0
Systolic blood pressure, automated reading	0.1	0.2	0.4	-0.6	0.3	0.6	-0.4	-0.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.8	0.4	-0.7	0.9	-0.8
Angina	1.1	1.5	2.0	1.3	1.4	-0.8	1.1	-1.4
Medication for hormone replacement therapy	1.6	1.8	2.4	-1.2	-1.4	1.0	-1.4	1.5
Vitamin and mineral supplements	6.3	8.5	11.8	-2.9	-3.4	2.3	-2.8	3.0
Supplements: Zinc	0.3	0.3	1.3	0.5	0.1	0.1	0.4	-1.1
Medication: Co-codamol	1.1	1.2	1.7	1.2	0.9	-1.0	1.2	-1.3
Medication: Metformin	0.1	0.2	0.5	0.7	-0.3	-0.5	0.3	0.2
Diabetes (father)	4.2	5.2	8.8	2.3	1.9	-3.0	2.5	-1.5
Diabetes (mother)	0.1	0.1	0.2	0.2	0.4	0.1	0.1	-0.5
Severe depression (siblings)	1.3	1.4	2.8	1.2	1.7	-0.8	1.1	-1.1
Pack years adult smoking proportion	0.3	0.5	1.1	-0.5	-1.1	0.2	-0.6	0.8
Impedance of leg (right)	0.9	4.5	14.1	-1.5	-3.8	-0.0	-1.1	2.2
Leg fat-free mass (left)	1.3	7.1	19.4	2.1	4.4	-0.4	1.8	-2.9
Trunk fat percentage	0.9	3.6	4.6	-2.1	-1.4	2.1	-2.1	1.6
Hand grip strength (right)	0.6	1.6	2.1	-1.3	-0.6	1.4	-1.3	1.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.1	0.4	0.3	-0.3	0.2
Current tobacco smoking	0.0	0.1	0.1	-0.2	0.2	0.4	-0.3	0.1
Average weekly fortified wine intake	0.8	0.9	1.4	0.9	0.8	-1.2	1.1	-0.6
Maternal smoking around birth	2.5	3.6	4.5	-2.1	-1.4	2.1	-2.1	1.7
Fed-up feelings	1.8	3.2	4.0	-1.8	-1.7	1.7	-1.8	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	0.7	1.0	-0.5	0.8	-0.9
Relative age voice broke	0.8	1.3	1.7	-1.2	-0.7	1.0	-1.3	1.3
Taking other prescription medications	0.2	0.3	1.1	0.3	0.2	0.5	0.4	-1.0
Age when periods started (menarche)	0.1	0.3	1.0	-0.6	-1.0	0.5	-0.4	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.4	-0.3	0.9	-0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	8.1	-0.8	-2.8	-1.2	-0.6	2.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	-1.0	-0.6	1.3	-1.1	0.9
Qualifications: CSEs or equivalent	0.4	0.5	1.1	-0.7	-0.6	0.2	-0.7	1.1
Serious illness, injury or assault to yourself	0.2	0.2	0.3	0.5	0.5	-0.4	0.3	-0.6
High blood pressure	0.5	1.5	4.4	0.4	2.1	0.7	0.3	-1.6
Hayfever, allergic rhinitis or eczema	1.6	3.6	4.1	1.9	1.8	-1.7	2.0	-2.0
Multivitamins +/- minerals	2.1	2.7	3.4	1.8	1.5	-1.8	1.6	-1.4
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.4	-0.3	-0.3	0.8	-0.6
Supplements: Glucosamine	0.2	0.3	0.8	0.0	-0.9	-0.7	0.4	0.1
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	4.2	-1.9	-1.5	1.4	-2.0	2.1
Medication: Atenolol	0.7	0.9	2.9	-0.7	0.2	1.7	-0.9	-0.3
Medication: Levothyroxine sodium	0.5	0.9	2.8	-0.8	0.1	1.7	-1.0	0.1
Sitting height	0.8	5.9	7.8	2.5	2.8	-2.6	2.4	-1.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.8	0.3	-0.6	0.5	-0.3
High blood pressure (mother)	1.7	2.4	4.0	1.4	2.0	-1.3	1.4	-1.4
Body mass index (BMI)	0.4	1.6	3.8	-1.4	0.1	1.9	-1.4	0.4
Impedance of leg (left)	0.6	2.7	9.8	-0.8	-3.1	-0.5	-0.4	1.6
Leg predicted mass (left)	1.4	7.3	19.8	2.1	4.5	-0.5	1.8	-2.9
Trunk fat mass	0.2	0.9	2.2	-1.0	0.1	1.5	-1.0	0.3
Waist circumference	0.3	1.2	3.1	-1.1	-0.0	1.8	-1.2	0.3
Number of incorrect matches in round	0.9	1.5	3.3	-1.4	-0.5	1.8	-1.3	0.5
Past tobacco smoking	0.6	1.1	1.7	-1.0	-1.3	0.8	-1.0	0.9
Alcohol usually taken with meals	0.6	0.9	2.5	0.9	-0.0	-1.6	1.0	-0.4
Nervous feelings	0.3	0.5	0.8	-0.6	0.9	0.9	-0.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.0	0.4	-0.2	0.0	0.3
Hearing difficulty/problems with background noise	2.0	3.1	5.6	1.6	2.4	-1.2	1.6	-1.9
Hair/balding pattern: Pattern 2	6.0	7.6	8.5	-2.9	-2.9	2.6	-2.8	2.6
Had menopause	1.2	1.5	2.3	1.4	0.5	-1.2	1.2	-1.5
Had other major operations	0.1	0.1	0.2	0.2	0.4	0.2	0.1	-0.4
Forced vital capacity (FVC)	0.2	0.8	1.5	1.0	1.2	-0.6	0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	10.7	-0.9	-3.3	-0.7	-1.0	2.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.1	0.4	0.1	0.3	-0.8
Qualifications: None of the above	0.0	0.1	0.3	-0.1	0.5	0.4	-0.1	0.0
Financial difficulties in last 2 years	0.0	0.0	0.1	0.1	0.2	-0.2	0.1	0.0
Mouth/teeth dental problems	0.1	0.1	0.2	0.2	0.4	-0.5	0.4	0.1
Heart attack	0.2	0.2	0.5	0.7	0.3	-0.3	0.5	-0.3
Allergy	0.1	0.2	0.4	-0.0	-0.3	-0.5	-0.2	0.6
Pain all over the body in last month	0.1	0.1	0.1	0.2	0.3	-0.3	-0.2	0.2
Diabetes (self-reported)	0.0	0.1	0.1	0.4	0.2	-0.3	0.3	-0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.1	0.8	0.9	-0.5	1.0	-1.0
Medication: Ramipril	0.4	0.5	1.3	-0.7	0.2	1.1	-0.6	-0.3
Medication: Simvastatin	0.6	1.0	2.8	0.5	1.1	0.2	0.7	-1.7
Fluid intelligence score	0.5	1.1	1.6	0.8	1.1	-0.9	1.0	-1.3
Illnesses of siblings	1.6	2.3	5.5	-1.2	-2.4	-0.2	-0.9	1.9
Neuroticism score	0.1	0.2	0.5	-0.3	0.7	0.7	-0.3	-0.0
Weight	0.4	1.8	5.6	0.7	2.4	0.4	0.6	-1.5
Impedance of arm (right)	1.2	5.5	11.8	-2.1	-3.4	0.7	-1.9	2.8
Arm fat percentage (right)	1.2	4.5	6.4	-2.4	-1.4	2.5	-2.4	1.6
Trunk fat-free mass	2.6	15.2	30.6	3.6	5.5	-1.8	3.3	-4.3
Hip circumference	0.2	0.7	2.6	0.2	1.6	0.4	0.2	-0.9
Time employed in main current job	0.1	0.1	0.2	0.2	-0.2	-0.4	0.2	-0.1
Alcohol intake versus 10 years previously	1.7	2.5	3.9	-1.6	-2.0	1.0	-1.5	1.6
Father’s age at death	0.0	0.1	0.1	-0.3	0.4	-0.3	0.0	0.0
Worrier / anxious feelings	1.0	1.9	3.2	-1.6	-1.0	1.8	-1.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	-0.5	0.4	1.1	-0.6	0.0
Falls in the last year	0.1	0.2	0.7	0.2	0.8	-0.0	-0.0	-0.3
Hair/balding pattern: Pattern 3	2.3	3.4	4.3	2.0	2.1	-1.7	1.9	-1.6
Number of live births	0.1	0.2	0.5	0.4	0.2	-0.2	0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.3	0.3	-0.2	0.2	0.3
Pulse rate	2.0	3.3	4.5	-2.1	-1.6	2.1	-1.9	1.3
Happiness	1.3	1.5	3.0	0.9	1.7	-0.8	1.0	-1.5
Noisy workplace	1.7	2.1	2.9	1.4	1.7	-1.0	1.4	-1.6
Qualifications: A levels/AS levels or equivalent	1.1	2.5	3.7	1.9	0.6	-1.5	1.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.1	1.1	1.4	-0.3	1.1	-1.7
Mouth/teeth dental problems: Dentures	0.9	1.5	2.9	-1.1	-1.7	0.9	-1.1	1.1
Asthma	0.5	0.9	2.1	-1.1	-0.1	1.4	-1.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	-0.8	-0.1	0.7	-0.5	0.3
Medication: Cholesterol lowering	0.6	0.9	2.5	0.8	0.5	-0.1	0.9	-1.6
Depression (self-reported)	0.4	0.5	0.6	0.8	0.5	-0.7	0.8	-0.7
Medication: Lansoprazole	0.1	0.1	0.3	-0.3	-0.4	0.2	-0.2	0.6
Prospective memory result	0.0	0.1	0.1	0.4	-0.0	-0.2	0.3	-0.0
Lung cancer (father)	0.2	0.2	0.6	-0.2	-0.3	0.8	-0.5	0.3
Illnesses of mother	1.5	1.9	3.4	-1.2	-1.8	0.3	-1.1	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.3	1.0	1.5	-0.9	1.0	-0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.2	-0.2	0.4	-0.2	0.5
Impedance of arm (left)	1.1	4.9	11.0	-1.9	-3.3	0.5	-1.6	2.7
Arm fat mass (right)	0.3	1.2	3.0	-1.1	0.2	1.7	-1.2	0.3
Trunk predicted mass	2.7	15.5	30.9	3.7	5.6	-1.8	3.3	-4.3
Standing height	2.1	20.4	27.6	4.6	5.3	-3.4	4.4	-4.7
Length of working week for main job	0.4	0.5	1.4	-0.6	-0.3	0.2	-0.7	1.2
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	0.0	0.1	0.1	-0.2
Breastfed as a baby	0.7	0.9	2.6	0.8	-0.3	-1.6	0.9	-0.2
Tense / ‘highly strung’	0.1	0.2	0.4	0.6	0.3	-0.4	0.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.4	0.6	0.1	0.4	-0.9
Hair/balding pattern: Pattern 4	1.0	2.4	5.5	1.0	2.3	-0.3	1.0	-2.1
Birth weight of first child	3.8	6.8	14.1	2.5	3.8	-1.6	2.2	-2.6
Peak expiratory flow (PEF)	0.7	1.6	2.7	-1.4	-0.8	1.6	-1.2	1.1
Pulse wave reflection index	0.1	0.1	0.5	0.7	0.1	-0.3	0.2	0.2
Ever highly irritable/argumentative for 2 days	3.5	4.2	5.4	2.2	2.1	-1.6	2.0	-2.3
Loud music exposure frequency	1.2	1.4	2.2	1.3	0.5	-1.3	1.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	1.0	0.3	-1.0	0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.0	0.1	0.3	-0.3	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	-0.3	-0.1	0.3	-0.4
Medication: Paracetamol	0.6	1.0	2.8	-1.0	-0.4	1.7	-0.9	0.1
Headache pain in last month	1.0	1.6	3.1	-1.6	-0.6	1.8	-1.2	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	0.1	-0.9	-0.9	-0.0	1.2
Glaucoma (self-reported)	1.2	1.4	1.9	1.4	1.3	-1.2	1.0	-1.0
Gout (self-reported)	0.2	0.3	0.9	-0.4	0.1	1.0	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.0	0.6	0.9	-0.1	-1.0
Medication: Amlodipine	0.4	0.6	1.9	0.4	1.4	0.0	0.4	-0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	-1.0	-0.7	1.1	-0.8	0.4
Birth weight	0.1	0.1	0.4	-0.3	0.7	0.2	-0.3	0.2
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.3	-1.0	0.0	1.8	-1.0	0.1
High blood pressure (siblings)	1.2	1.7	4.8	0.7	2.2	0.4	0.6	-1.7
Forced vital capacity (FVC), Best measure	0.7	2.7	4.3	1.7	2.1	-1.4	1.7	-1.3
Body fat percentage	0.9	3.7	4.8	-2.2	-1.5	2.2	-2.1	1.6
Leg fat percentage (right)	0.9	3.4	4.3	-2.0	-1.7	2.1	-1.9	1.4
Arm fat-free mass (right)	1.9	9.9	21.5	2.8	4.6	-1.1	2.5	-3.5
Exposure to tobacco smoke outside home	1.0	1.3	2.3	1.1	1.3	-0.5	1.0	-1.5
Comparative body size at age 10	0.5	1.3	2.3	1.1	1.0	-0.9	1.1	-1.5
Number of full brothers	0.2	0.3	0.6	-0.2	0.7	0.8	-0.3	-0.2
Worry too long after embarrassment	0.1	0.2	0.6	-0.8	-0.5	0.2	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.0	0.4	0.3	0.1	-0.7
Wheeze or whistling in the chest in last year	0.6	1.1	1.4	-1.2	-0.9	1.2	-1.0	0.9
Number of children fathered	0.1	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	3.5	1.8	1.2	-1.7	1.7	-1.9
Age at first live birth	0.2	0.3	0.7	0.5	-0.3	-0.8	0.6	-0.4
Pulse wave peak to peak time	0.4	0.5	0.8	0.3	0.7	-0.9	0.7	-0.9
Health satisfaction	0.8	1.0	1.8	-1.3	-0.8	1.2	-1.1	0.3
Shortness of breath walking on level ground	1.2	1.4	2.9	-1.3	0.2	1.7	-1.5	0.6
Qualifications: College or University degree	1.2	3.9	5.4	2.0	1.8	-2.3	2.1	-1.5
Eye problems/disorders: None of the above	3.4	4.0	4.8	-2.2	-2.2	1.6	-1.9	2.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.1	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.2	-0.6	0.0	1.1	-0.7	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	0.6	-0.3	-1.3	0.4	0.3
Neck or shoulder pain in last month	0.6	0.9	2.0	-0.0	1.4	0.3	0.5	-1.4
Medication: Blood pressure	0.6	1.0	2.3	0.2	1.5	0.7	0.3	-1.5
Angina (self-reported)	0.7	0.9	1.6	1.0	1.3	-0.5	0.7	-1.1
Migraine (self-reported)	0.2	0.3	1.0	-0.3	-0.4	1.0	-0.2	-0.4
Medication: Ibuprofen	2.3	2.7	4.3	-2.1	-1.1	1.9	-1.7	1.3
Medication: Allopurinol	0.1	0.1	0.2	-0.0	0.3	0.5	-0.1	-0.2
Medication: Omeprazole	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	-0.2
Medication: Seretide 50 evohaler	0.8	0.9	2.4	0.3	1.6	0.3	0.5	-1.2
Mean time to correctly identify matches	0.7	1.3	2.8	1.1	1.7	-0.2	0.8	-1.3
Heart disease (mother)	0.3	0.4	0.9	-0.2	0.8	1.0	-0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.0	-0.3	0.6	-0.1	-0.3
Whole body fat mass	0.2	1.0	2.7	-1.1	0.2	1.6	-1.1	0.3
Leg fat mass (right)	0.2	0.6	1.9	-0.7	0.2	1.4	-0.8	-0.0
Arm predicted mass (right)	2.1	10.9	23.5	3.0	4.9	-1.2	2.6	-3.7
Pulse rate, automated reading	0.1	0.5	0.9	-0.9	-0.3	0.9	-0.8	0.1
Alcohol intake frequency.	0.2	0.4	0.5	-0.7	0.3	0.7	-0.7	0.5
Comparative height size at age 10	3.2	17.9	21.0	4.6	4.5	-3.5	4.3	-4.2
Number of full sisters	0.9	1.1	1.7	0.9	1.2	-0.6	0.9	-1.3
Suffer from ‘nerves’	0.8	1.3	2.0	-1.4	-0.3	1.4	-1.2	0.9
Overall health rating	0.2	0.5	1.3	-0.3	0.8	1.1	-0.5	-0.5
Chest pain or discomfort	0.3	0.4	0.8	0.6	0.8	-0.2	0.5	-0.9
Had major operations	2.1	2.5	3.9	-2.0	-1.6	1.6	-1.5	1.2
Age at last live birth	1.0	1.5	1.9	1.2	0.6	-1.3	1.4	-1.4
Family relationship satisfaction	0.9	1.0	1.8	1.0	1.2	-0.4	0.9	-1.3
Leg pain on walking	0.2	0.2	0.8	-0.3	-0.9	0.3	-0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.1	0.0	-0.3	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.7	-0.1	-0.7	0.5	-0.0
Medication: Aspirin	0.3	0.4	1.1	0.6	0.6	0.0	0.5	-1.1
Supplements: Vitamin C	0.6	0.7	0.9	0.9	0.8	-0.8	0.9	-0.6
Knee pain experienced in last month	0.3	0.4	1.5	-0.5	-1.2	0.4	-0.3	0.2
Hypertension (Self-reported)	0.7	1.9	4.8	0.6	2.2	0.5	0.5	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.5	4.1	4.9	-2.0	-2.2	2.1	-2.0	1.8
Illnesses of father: Heart disease	0.5	0.7	1.4	0.6	1.2	-0.4	0.9	-1.0
Illnesses of siblings: Diabetes	0.6	0.7	1.4	1.2	1.1	-0.3	0.7	-0.7
Smoking status: Previous	0.8	1.1	1.8	1.1	1.4	-0.9	1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.1	1.1	0.7	-0.3	0.1
Whole body fat-free mass	2.3	13.2	29.1	3.3	5.4	-1.4	2.9	-4.0
Leg fat-free mass (right)	1.8	9.4	24.0	2.5	4.9	-0.7	2.2	-3.3
Arm fat percentage (left)	1.2	4.7	6.5	-2.4	-1.5	2.5	-2.4	1.7
Average weekly red wine intake	0.3	0.5	1.0	0.8	0.5	-1.0	0.7	-0.3
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.8	-1.3	-0.7	1.7	-1.4	1.1
Mood swings	0.2	0.4	1.2	-0.7	0.2	1.1	-0.7	0.2
Loneliness, isolation	0.5	0.6	1.2	-0.9	0.2	0.5	-0.9	1.1
Long-standing illness, disability or infirmity	1.9	3.0	5.4	1.7	1.6	-0.9	1.8	-2.3
Ever had bowel cancer screening	1.3	1.5	3.1	1.3	1.2	-0.3	1.1	-1.8
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.5	0.1	-0.2	0.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.5	0.7	-1.0	0.7	-0.4
Friendships satisfaction	1.8	2.2	3.0	1.4	1.7	-1.3	1.4	-1.6
Qualifications: nursing, teaching	1.5	2.3	3.6	1.9	1.0	-1.3	1.6	-1.7
Commuting to job workplace: Walk	0.8	0.8	2.3	-0.8	-0.7	0.3	-0.8	1.5
Eye problems/disorders: Cataract	0.2	0.3	1.1	-0.2	0.3	1.1	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	-0.1	-0.7	0.1	-0.3	0.1
Medication for cholesterol	0.8	1.3	1.8	1.0	1.1	-0.9	1.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	0.6	0.5	-0.5	0.5	-0.4
Back pain experienced in last month	1.9	2.8	3.8	1.8	1.5	-1.6	1.9	-1.6
Mineral and other dietary supplements	1.4	1.8	3.4	-1.3	-0.5	1.8	-1.6	1.2
Breast cancer (self-reported)	0.5	0.6	1.9	0.8	-0.0	-1.4	0.8	0.1
Asthma (self-reported)	0.4	0.8	2.0	-1.0	0.1	1.4	-0.9	0.4
Osteoporosis (self-reported)	0.3	0.4	1.2	0.5	1.1	-0.4	0.5	-0.5
Osteoarthritis (self-reported)	1.2	1.6	3.8	-1.2	-2.0	0.7	-1.0	1.1
Medication: Aspirin	0.0	0.0	0.1	0.0	-0.3	0.3	-0.1	-0.1
Medication: Gliclazide	0.2	0.2	0.3	0.4	0.6	-0.4	0.4	-0.3
Illnesses of father: None of the above (group 1)	1.8	2.2	2.6	-1.3	-1.6	1.4	-1.6	1.5
Smoking status: Current	0.1	0.2	0.4	-0.3	-0.1	0.7	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	-0.6	-0.9	1.1	-0.7	0.7
Whole body water mass	2.3	13.1	28.9	3.2	5.4	-1.4	2.9	-4.0
Leg predicted mass (right)	1.8	9.5	24.1	2.5	4.9	-0.8	2.2	-3.3
Arm fat mass (left)	0.3	1.1	3.1	-1.1	0.3	1.8	-1.1	0.2
Number of self-reported non-cancer illnesses	0.7	1.2	3.1	-1.1	-0.8	1.8	-1.0	0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.8	-0.4	-1.0	0.7	-0.2
Miserableness	0.0	0.1	0.2	-0.2	0.2	0.5	-0.2	0.2
Guilty feelings	0.2	0.4	1.2	0.0	1.1	-0.5	0.4	-0.6
Wears glasses or contact lenses	0.4	0.5	0.9	0.4	0.9	-0.1	0.5	-1.0
Ever taken oral contraceptive pill	0.5	0.5	1.1	0.4	0.9	-0.3	0.7	-1.0
Hearing aid user	3.6	4.0	6.7	-1.6	-2.6	1.1	-1.9	2.5
Mother’s age at death	2.0	2.5	3.8	1.6	1.0	-2.0	1.7	-1.3
Financial situation satisfaction	0.1	0.2	0.3	0.5	0.3	-0.5	0.4	-0.2
Tinnitus: Yes, now most or all of the time	4.2	4.9	6.1	2.4	1.6	-2.5	2.4	-2.0
Commuting to job workplace: Public transport	0.5	0.6	1.7	0.7	-0.2	-1.3	0.7	-0.2
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	1.4	1.1	-1.1	1.0	-1.0
Medication: Blood pressure	0.1	0.1	0.3	0.4	0.5	-0.1	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.6	0.1	-0.2	0.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.5	0.9	0.4	-1.6	1.3	-0.8
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.0	-0.8	-0.3	-0.1	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.7	-0.1	0.8	0.2	0.1	-0.3
Medication: Paracetamol	1.0	1.5	3.6	-1.2	-0.6	1.9	-1.3	0.6
Medication: Lisinopril	0.7	1.0	3.3	-0.6	0.3	1.8	-1.0	0.2
Medication: Atorvastatin	0.5	0.6	1.2	0.4	-1.1	-1.1	0.2	0.7
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.0	0.3	-0.7	0.2	0.1
Alcohol drinker status: Never	1.0	1.2	2.5	0.9	1.5	0.0	0.8	-1.6
Ever smoked	0.3	0.6	0.8	0.7	0.9	-0.5	0.8	-0.8
Basal metabolic rate	1.7	9.4	22.7	2.6	4.8	-0.9	2.3	-3.4
Leg fat percentage (left)	0.5	1.9	3.0	-1.5	-1.2	1.7	-1.5	0.9
Arm fat-free mass (left)	2.1	10.8	22.8	3.0	4.8	-1.2	2.7	-3.8
Number of operations (self-reported)	1.0	1.5	3.1	-1.5	0.0	1.8	-1.4	0.6
Average weekly beer plus cider intake	0.4	0.6	0.8	-0.7	-0.8	0.9	-0.8	0.6
Irritability	0.4	0.6	1.5	0.7	1.2	-0.3	0.7	-0.9
Risk taking	0.8	1.2	1.8	1.0	1.2	-0.7	1.2	-1.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	-0.4	0.5	-0.2	-0.3
Fractured/broken bones in last 5 years	0.6	0.8	2.1	-0.6	0.9	1.5	-0.8	-0.1
Age started oral contraceptive pill	0.4	0.5	2.1	0.1	-1.4	-0.2	-0.1	0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.9	-0.1	0.6	-0.8	0.6
Ever depressed for a whole week	1.1	1.4	2.4	1.2	1.0	-0.7	1.3	-1.6
Unable to work because of sickness or disability	1.7	2.1	3.0	-1.5	-0.8	1.6	-1.7	1.5
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.6	0.4	-0.0	0.3	0.0
Myopia	1.9	2.8	3.5	1.5	1.3	-1.8	1.9	-1.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.4	-0.4	-2.1	-0.6	-0.4	1.5
Cholesterol lowering medication	0.3	0.5	0.6	-0.7	-0.7	0.5	-0.8	0.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.0	0.3	0.4	0.1	-0.6
Pain experienced in last month	0.1	0.2	0.3	0.1	-0.6	-0.6	-0.1	0.4
Supplements: Calcium	1.5	1.6	2.0	1.4	0.9	-1.4	1.3	-1.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-0.2	1.1	0.4	-0.3	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	0.7	0.4	-0.3	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.3	-0.4	0.2	0.1	-0.3
Heart disease (siblings)	0.6	0.7	3.1	0.4	1.8	-0.1	0.2	-0.6
Alcohol drinker status: Previous	2.5	2.9	4.0	-2.0	-0.5	1.7	-1.9	1.9
Pack years of smoking	0.1	0.2	0.5	-0.1	-0.7	-0.1	-0.2	0.4
Impedance of whole body	1.1	5.4	14.4	-1.8	-3.8	0.3	-1.5	2.7
Leg fat mass (left)	0.1	0.6	1.8	-0.7	0.2	1.4	-0.7	-0.1
Arm predicted mass (left)	1.8	9.0	19.1	2.7	4.4	-1.1	2.4	-3.4