Hub : Genes

C6orf142

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0610	0.0330	0.0050	0.007	0.018	0.007	NA	0.008	0.077	0.0100	0.083	NA	0.0640
2	TCGA	Breast Invasive Carcinoma	0.0335	0.0185	0.0074	0.005	0.000	-0.001	NA	-0.001	0.023	0.2900	0.440	NA	0.5900
3	TCGA	Esophageal Carcinoma	0.2690	0.1040	0.0071	0.007	0.083	0.032	NA	0.052	0.180	0.0013	0.035	NA	0.0097

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.1	2.0	-1.4	-0.8	-0.8
Depressed Affect (Nagel 2018)	1.6	3.3	4.4	-1.9	-1.3	-2.1
Depression (Nagel 2018)	4.3	6.4	10.1	-3.2	-2.2	-2.1
Intelligence (Savage-Jansen 2018)	1.9	5.8	9.5	3.1	1.9	2.0
Neuroticism (Nagel 2018)	0.4	0.8	2.2	-1.5	0.5	-0.2
Schizophrenia (2018)	0.7	1.4	2.3	-1.5	-1.1	-0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	-1.1	-1.7	0.1
Worry (Nagel 2018)	1.2	2.5	4.4	-1.4	2.1	1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.2	0.6	-0.7
Alzheimer’s Disease (in father)	1.3	1.4	3.5	-0.8	-1.9	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	-0.8	-0.8	-1.0
Crohns Disease (2017)	0.4	0.9	1.6	-0.7	-0.8	-1.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	0.2	-1.4	0.0
Ulcerative Colitis (UC)	0.6	1.2	1.6	1.1	-1.3	0.9
Major Depression (MDD)	0.5	0.7	1.0	-1.0	-0.3	-1.0
Reaction Time	0.7	1.4	2.6	1.6	0.4	1.2
Verbal and Numeric Reasoning (VNR)	2.8	6.7	11.8	3.4	1.3	2.5
Breast Cancer	0.8	1.9	3.1	-1.8	0.4	-1.6
Ovarian Cancer	4.4	5.8	8.8	-3.0	-1.7	-2.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.1	0.1	0.4	-0.2	0.0
Bipolar Disorder (2011)	0.5	0.5	1.0	0.6	0.2	1.0
Body Mass Index (BMI) (2010)	3.6	4.9	8.6	-1.4	-2.9	-2.1
Coronary Artery Disease (CAD)	1.5	1.8	3.0	-1.1	-1.7	1.1
Crohns Disease (2012)	0.2	0.3	0.9	0.2	-0.2	1.0
Mean Putamen Volume	0.4	0.5	1.1	1.0	0.7	-0.1
Fasting Glucose	0.7	0.8	1.0	0.8	0.8	1.0
HbA1C	0.3	0.3	0.6	0.0	0.6	0.8
HDL Cholesterol	0.7	1.2	2.1	0.2	1.5	-1.1
LDL Cholesterol	1.6	2.5	2.9	1.6	1.7	1.5
Lupus	0.1	0.1	0.3	-0.5	0.2	-0.2
Neuroticism (2016)	1.2	1.8	2.8	-1.7	-0.5	-1.5
Primary Biliary Cirrhosis	0.7	0.9	1.9	-0.9	-1.4	-0.2
Rheumatoid Arthritis	1.5	2.0	5.8	-2.4	-0.3	-0.4
Schizophrenia (2014)	1.0	2.2	3.2	-1.8	-1.7	-0.7
Triglycerides	1.1	1.8	3.9	1.0	0.8	2.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.1	-0.4	0.3
Ulcerative Colitis	0.9	1.3	3.5	-0.3	-1.9	0.7
Blood Eosinophil Count	0.2	1.4	2.0	-1.4	0.5	-1.4
Blood Platelet Count	0.1	1.5	4.0	-0.2	2.0	0.6
Blood Red Count	0.3	2.5	4.0	-2.0	0.3	-1.8
Blood White Count	0.4	2.9	5.9	-2.4	-1.2	-1.2
Heel T-Score	0.3	2.6	4.1	2.0	-0.3	1.9
BMI	4.0	23.1	24.9	-4.9	-4.5	-5.0
Height	0.1	2.2	4.8	0.1	-2.2	-1.3
Waist Hip Ratio (WHR)	0.3	1.2	1.9	1.3	1.4	0.3
Systolic Blood Pressure	3.1	15.6	27.3	-5.2	-1.6	-4.1
Smoking Status	2.6	6.3	7.4	-2.6	-2.2	-2.7
Allergy or Eczema	0.6	1.5	4.6	-0.1	2.1	0.2
Cardiovascular Disease	2.1	6.8	9.9	-3.1	-2.2	-2.4
Hypothyroidism (self reported)	0.3	0.6	1.2	1.1	-0.7	-0.3
Respiratory disease	0.2	0.3	0.9	-0.2	0.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.5	-1.2	-0.6
Lung FEV1/FVC ratio	0.2	1.1	2.8	1.7	-0.5	0.5
Lung FVC	0.4	2.3	4.4	2.1	0.0	1.5
Neuroticism	0.4	1.1	1.5	-0.9	0.9	-1.2
Chronotype (morning person)	1.7	3.9	5.5	2.3	1.0	2.3
Hair Pigment	0.0	0.1	0.2	-0.4	0.1	-0.3
Tanning	0.0	0.4	0.9	-0.1	-0.5	0.9
Hand grip strength (left)	0.1	0.4	1.0	0.3	-1.0	-0.2
Number of treatments/medications taken	4.0	7.1	12.9	-2.5	-1.5	-3.6
Average weekly spirits intake	3.0	3.7	5.1	-1.8	-1.7	-2.3
Sensitivity / hurt feelings	0.1	0.2	0.3	0.5	-0.6	0.2
Frequency of depressed mood in last 2 weeks	2.7	3.8	4.9	-2.2	-1.5	-2.1
Hearing difficulty/problems: Yes	2.7	4.1	6.4	1.1	2.5	2.2
Relative age of first facial hair	1.2	2.4	3.3	1.1	1.8	1.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.9	-0.9	-0.4	0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-0.5	-0.2	-1.6
Ever had hysterectomy (womb removed)	1.7	1.9	3.4	-1.8	0.2	-1.5
Systolic blood pressure, automated reading	2.2	6.4	11.0	-2.5	-1.3	-3.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	-0.0	-0.8	-1.1
Angina	0.2	0.3	0.5	0.7	-0.6	-0.1
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.0	-0.7	-0.5
Vitamin and mineral supplements	0.7	0.9	1.3	0.3	1.1	1.2
Supplements: Zinc	1.7	1.8	2.8	-1.7	0.2	-1.6
Medication: Co-codamol	0.2	0.2	0.4	-0.5	-0.6	-0.3
Medication: Metformin	1.4	2.0	3.5	-1.2	-1.9	-1.0
Diabetes (father)	0.8	1.0	1.5	-1.2	0.7	-0.9
Diabetes (mother)	1.3	1.7	4.4	-0.7	-0.3	-2.1
Severe depression (siblings)	0.7	0.8	1.5	-0.8	1.2	-0.3
Pack years adult smoking proportion	2.9	4.4	8.5	-1.9	-0.9	-2.9
Impedance of leg (right)	2.7	13.0	26.0	2.5	5.1	2.7
Leg fat-free mass (left)	3.5	18.5	24.7	-3.3	-5.0	-4.5
Trunk fat percentage	3.6	14.2	20.1	-4.2	-2.2	-4.5
Hand grip strength (right)	0.2	0.6	1.6	0.3	-1.3	0.2
Townsend deprivation index at recruitment	0.5	0.7	1.1	-1.0	0.1	-1.1
Current tobacco smoking	3.5	5.7	7.2	-2.3	-2.1	-2.7
Average weekly fortified wine intake	3.9	4.6	7.1	2.0	2.7	1.6
Maternal smoking around birth	1.2	1.8	4.2	-2.1	-0.3	-1.0
Fed-up feelings	1.2	2.1	2.8	-1.5	-1.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	6.7	-2.6	-1.6	-1.8
Relative age voice broke	1.8	2.8	5.2	1.4	1.1	2.3
Taking other prescription medications	0.2	0.4	0.9	-0.2	-0.4	-1.0
Age when periods started (menarche)	0.6	1.5	2.6	-0.9	-1.6	-1.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.1	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	4.7	2.1	0.7	2.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.5	-0.3	-0.1
Qualifications: CSEs or equivalent	0.9	1.2	2.7	-1.6	-0.6	-0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	-0.3	-0.1
High blood pressure	2.9	8.0	11.3	-3.4	-2.3	-2.7
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.6	-0.0	1.9	0.3
Multivitamins +/- minerals	1.3	1.7	2.7	-1.4	-0.5	-1.6
Stomach or abdominal pain in last month	1.0	1.2	1.6	-1.2	-0.9	-1.1
Supplements: Glucosamine	0.7	0.9	2.4	-0.6	-0.1	-1.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	0.3	0.7	-0.7
Medication: Atenolol	2.3	2.8	3.5	-1.3	-1.9	-1.9
Medication: Levothyroxine sodium	0.4	0.7	0.9	-0.9	-0.9	-0.5
Sitting height	0.2	1.1	2.4	-1.0	-1.5	-0.3
Chronic bronchitis/emphysema (father)	1.2	1.4	3.4	0.4	-1.8	0.8
High blood pressure (mother)	2.0	2.9	4.5	-1.4	-1.4	-2.1
Body mass index (BMI)	4.7	20.0	24.2	-4.3	-4.2	-4.9
Impedance of leg (left)	3.1	15.1	33.2	2.3	5.8	2.6
Leg predicted mass (left)	3.5	18.5	24.6	-3.3	-5.0	-4.5
Trunk fat mass	4.4	18.8	25.4	-4.4	-3.4	-5.0
Waist circumference	2.6	9.4	14.1	-3.0	-2.2	-3.8
Number of incorrect matches in round	0.7	1.2	1.8	0.8	1.3	-1.0
Past tobacco smoking	0.7	1.2	2.1	1.4	0.4	1.2
Alcohol usually taken with meals	1.1	1.7	2.9	1.7	-0.2	1.5
Nervous feelings	1.8	3.3	8.5	-0.0	2.9	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.0	-2.0	0.1	-0.7
Hearing difficulty/problems with background noise	4.4	7.1	13.5	1.3	3.7	2.5
Hair/balding pattern: Pattern 2	1.7	2.2	2.6	1.6	1.5	1.3
Had menopause	0.3	0.4	0.8	0.9	0.3	0.7
Had other major operations	0.5	0.7	1.7	-0.0	-1.3	0.5
Forced vital capacity (FVC)	0.3	1.3	3.4	1.8	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	5.4	2.1	0.4	2.3
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.8	-0.4	2.2	1.0
Qualifications: None of the above	0.3	0.7	1.2	-0.0	1.1	-1.0
Financial difficulties in last 2 years	7.1	9.6	11.3	-2.9	-3.4	-3.0
Mouth/teeth dental problems	3.1	4.7	6.4	2.4	1.4	2.5
Heart attack	0.2	0.2	0.4	0.6	0.4	-0.3
Allergy	0.6	1.3	3.6	0.1	-1.9	0.6
Pain all over the body in last month	0.7	0.7	1.0	-1.0	-0.7	-0.8
Diabetes (self-reported)	0.3	0.4	0.8	0.9	0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.2	0.8	-0.4
Medication: Ramipril	0.2	0.3	0.4	-0.5	-0.4	-0.6
Medication: Simvastatin	0.8	1.1	2.6	-0.8	-0.4	-1.6
Fluid intelligence score	2.0	4.1	8.5	2.9	1.3	1.4
Illnesses of siblings	2.5	3.5	8.0	0.5	1.5	2.8
Neuroticism score	0.6	1.3	1.8	-1.4	0.8	-1.1
Weight	4.3	21.0	26.1	-4.2	-4.4	-5.1
Impedance of arm (right)	1.2	5.4	9.6	0.7	3.1	2.5
Arm fat percentage (right)	4.3	16.8	20.9	-4.6	-3.4	-4.2
Trunk fat-free mass	1.6	9.3	15.8	-1.5	-4.0	-3.1
Hip circumference	2.0	8.8	10.0	-3.1	-2.6	-3.2
Time employed in main current job	2.1	2.4	5.9	0.9	0.8	2.4
Alcohol intake versus 10 years previously	3.8	5.7	12.3	-3.5	-0.5	-2.1
Father’s age at death	1.8	2.4	3.9	2.0	1.1	1.4
Worrier / anxious feelings	0.3	0.6	1.2	-1.1	-0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	3.2	5.2	7.1	-2.7	-1.9	-2.2
Falls in the last year	0.3	0.4	0.8	-0.9	-0.4	-0.6
Hair/balding pattern: Pattern 3	2.6	3.8	6.2	-2.5	-1.7	-1.6
Number of live births	0.6	0.8	1.4	-1.2	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.9	2.0	-0.2	0.9
Pulse rate	3.4	5.8	7.0	2.6	1.9	2.6
Happiness	0.6	0.7	1.9	-1.4	0.1	0.5
Noisy workplace	0.2	0.3	0.8	-0.9	-0.0	0.2
Qualifications: A levels/AS levels or equivalent	1.6	3.5	8.9	3.0	0.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.7	0.1	-0.2
Mouth/teeth dental problems: Dentures	2.5	4.3	10.6	-1.0	-1.1	-3.3
Asthma	0.4	0.8	1.9	0.4	0.7	-1.4
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	5.5	-2.0	-2.3	-1.6
Medication: Cholesterol lowering	0.2	0.4	0.6	0.2	0.7	-0.8
Depression (self-reported)	2.0	2.5	4.9	-1.2	-1.0	-2.2
Medication: Lansoprazole	2.3	2.6	5.9	2.4	1.4	-0.1
Prospective memory result	0.3	0.3	0.6	0.8	0.1	0.6
Lung cancer (father)	0.2	0.2	0.5	-0.4	0.0	-0.7
Illnesses of mother	2.1	2.6	4.3	1.1	1.5	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.4	2.1	-0.4	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	2.2	-0.0	1.5	-0.0
Impedance of arm (left)	1.2	5.5	7.8	0.9	2.8	2.8
Arm fat mass (right)	4.9	20.3	23.2	-4.4	-4.2	-4.8
Trunk predicted mass	1.6	9.4	15.8	-1.6	-4.0	-3.1
Standing height	0.1	1.0	1.8	-0.3	-1.4	-1.1
Length of working week for main job	0.9	1.0	2.9	-0.2	-1.7	-0.3
Exposure to tobacco smoke at home	3.4	3.8	7.1	-2.0	-0.4	-2.7
Breastfed as a baby	1.1	1.3	1.4	-1.2	-1.1	-1.2
Tense / ‘highly strung’	1.0	1.6	4.1	-0.8	2.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	8.9	-1.3	-0.6	-3.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	-0.1	-1.1	-0.5
Birth weight of first child	1.5	2.7	6.0	2.5	0.6	1.2
Peak expiratory flow (PEF)	0.2	0.5	0.8	-0.4	-0.8	-0.9
Pulse wave reflection index	1.2	1.5	4.4	0.0	2.1	-0.4
Ever highly irritable/argumentative for 2 days	1.7	2.1	5.8	-0.1	2.4	0.6
Loud music exposure frequency	0.5	0.5	1.1	-1.0	-0.3	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	0.7	-1.2	-0.0
Mouth/teeth dental problems: Bleeding gums	3.6	4.6	9.6	-3.1	-1.6	-1.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.0	-0.4	-0.2
Medication: Paracetamol	2.7	4.4	9.0	-3.0	-1.5	-1.4
Headache pain in last month	0.5	0.9	2.5	-1.6	0.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.3	0.3	1.4
Glaucoma (self-reported)	0.7	0.8	0.9	-0.9	-0.9	-0.8
Gout (self-reported)	0.1	0.2	0.5	-0.1	-0.7	-0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.1	0.1	-0.5
Medication: Amlodipine	0.7	0.9	2.2	-0.7	0.3	-1.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.2	0.1	-0.9	-1.8
Birth weight	0.1	0.2	0.7	0.1	-0.0	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	-0.3	-0.6	0.1
High blood pressure (siblings)	0.8	1.2	1.9	-0.9	-0.9	-1.4
Forced vital capacity (FVC), Best measure	0.4	1.5	3.5	1.9	-0.3	1.0
Body fat percentage	3.3	13.2	18.1	-4.2	-2.1	-4.2
Leg fat percentage (right)	2.4	8.6	13.5	-3.2	-1.5	-3.7
Arm fat-free mass (right)	1.8	9.3	12.5	-1.8	-3.5	-3.5
Exposure to tobacco smoke outside home	2.0	2.7	3.4	-1.8	-1.5	-1.6
Comparative body size at age 10	4.5	12.5	27.7	-2.0	-5.3	-2.5
Number of full brothers	2.6	3.2	6.3	-2.5	-1.2	-1.4
Worry too long after embarrassment	0.8	1.3	1.9	1.0	1.0	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	0.4	0.2
Wheeze or whistling in the chest in last year	0.7	1.3	2.6	-1.1	-0.3	-1.6
Number of children fathered	0.4	0.4	1.0	-1.0	-0.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.6	1.6	0.2	0.0
Age at first live birth	0.9	1.5	4.0	0.8	2.0	-0.2
Pulse wave peak to peak time	0.8	0.9	2.7	-0.0	-1.6	-0.0
Health satisfaction	2.4	3.1	7.7	-2.8	-1.2	-0.5
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	-0.9	-0.3
Qualifications: College or University degree	0.5	1.7	3.1	1.8	-0.2	1.3
Eye problems/disorders: None of the above	1.2	1.4	4.0	-0.1	2.0	0.1
Mouth/teeth dental problems: Loose teeth	2.3	2.7	3.2	-1.8	-1.7	-1.4
Emphysema/chronic bronchitis	4.4	5.0	7.5	-2.6	-0.8	-2.7
Medication for pain relief, constipation, heartburn	3.0	5.1	6.9	2.6	1.3	2.6
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.3	0.2	-0.5
Medication: Blood pressure	0.6	1.0	2.8	-0.4	0.1	-1.7
Angina (self-reported)	0.4	0.5	0.9	0.6	-1.0	-0.4
Migraine (self-reported)	0.5	0.6	1.7	1.3	0.3	0.1
Medication: Ibuprofen	4.1	4.9	5.7	-2.0	-2.2	-2.4
Medication: Allopurinol	1.0	1.3	3.2	-0.5	-1.8	-0.6
Medication: Omeprazole	0.2	0.2	0.4	0.4	0.6	-0.3
Medication: Seretide 50 evohaler	0.5	0.5	1.3	1.1	-0.3	-0.4
Mean time to correctly identify matches	1.5	2.9	6.1	2.5	0.1	1.6
Heart disease (mother)	0.8	0.9	1.5	0.7	-0.9	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.2	-1.4	0.4	-1.8
Whole body fat mass	4.3	18.1	24.4	-4.3	-3.4	-4.9
Leg fat mass (right)	4.5	17.4	24.9	-4.0	-3.3	-5.0
Arm predicted mass (right)	2.1	11.0	15.1	-1.9	-3.9	-3.8
Pulse rate, automated reading	10.6	34.4	46.4	6.8	4.0	6.4
Alcohol intake frequency.	0.2	0.5	0.9	-0.9	0.7	-0.4
Comparative height size at age 10	0.7	3.7	8.8	-0.1	-3.0	-1.5
Number of full sisters	0.2	0.2	0.6	0.1	-0.8	-0.0
Suffer from ‘nerves’	0.7	1.2	3.3	-1.8	0.4	0.1
Overall health rating	4.7	10.1	18.1	-4.2	-2.0	-2.9
Chest pain or discomfort	0.5	0.7	1.8	-1.4	0.4	-0.4
Had major operations	0.3	0.3	0.8	0.9	-0.3	-0.2
Age at last live birth	0.6	0.8	2.0	0.0	1.4	-0.7
Family relationship satisfaction	0.6	0.7	0.9	-1.0	1.0	0.5
Leg pain on walking	0.2	0.2	0.6	0.1	-0.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	-0.5	-0.6	-0.8
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.3	-0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	0.6	1.0	1.3
Medication: Aspirin	2.2	2.9	6.7	-1.3	-0.6	-2.6
Supplements: Vitamin C	0.0	0.0	0.1	0.1	-0.1	0.3
Knee pain experienced in last month	3.5	5.4	6.7	-2.6	-2.0	-2.4
Hypertension (Self-reported)	2.9	8.0	12.4	-3.5	-2.0	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.1	-0.4	0.6	-2.2
Illnesses of father: Heart disease	0.5	0.7	1.6	-0.4	-0.5	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	1.9	-0.3	-1.1	-1.4
Smoking status: Previous	0.8	1.2	2.8	-1.7	0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	2.8	-1.5	-1.7	-1.0
Whole body fat-free mass	2.2	12.4	18.7	-2.2	-4.3	-3.7
Leg fat-free mass (right)	3.3	17.5	22.5	-3.4	-4.7	-4.3
Arm fat percentage (left)	4.1	16.3	20.2	-4.5	-3.4	-4.1
Average weekly red wine intake	1.1	1.7	2.6	1.6	0.3	1.6
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.1	1.2	0.8	-1.4
Mood swings	0.4	0.7	1.2	-0.9	0.0	-1.1
Loneliness, isolation	4.5	6.2	12.8	-2.3	-0.7	-3.6
Long-standing illness, disability or infirmity	0.6	1.0	2.2	-1.5	-0.5	-0.7
Ever had bowel cancer screening	0.1	0.1	0.4	-0.1	0.1	-0.6
Diabetes diagnosed by doctor	0.3	0.5	0.8	0.7	-0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	4.1	-2.0	-1.5	0.5
Friendships satisfaction	0.5	0.6	1.5	-0.3	1.2	0.5
Qualifications: nursing, teaching	0.6	0.9	2.1	1.4	0.6	0.6
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.3	-0.0	0.7
Eye problems/disorders: Cataract	0.9	1.1	2.5	-0.3	-1.6	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.4	-0.8	1.5	-0.6
Medication for cholesterol	0.6	0.9	1.4	1.1	1.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.4	0.6	0.6	-0.6
Back pain experienced in last month	0.5	0.7	1.5	-1.2	-0.6	-0.4
Mineral and other dietary supplements	1.4	1.8	3.6	0.9	1.0	1.9
Breast cancer (self-reported)	0.2	0.2	0.6	-0.2	0.2	0.8
Asthma (self-reported)	0.4	0.8	1.7	0.4	0.7	-1.3
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.8	-0.2	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.8	0.7	0.5
Medication: Aspirin	2.3	2.9	6.0	-1.4	-1.0	-2.4
Medication: Gliclazide	0.6	0.6	1.0	-1.0	-1.0	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	0.2	0.9	1.2
Smoking status: Current	2.5	4.0	5.5	-1.8	-1.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.9	2.2	-0.3	1.9
Whole body water mass	2.1	12.1	18.7	-2.2	-4.3	-3.6
Leg predicted mass (right)	3.1	16.5	21.1	-3.3	-4.6	-4.2
Arm fat mass (left)	4.5	18.5	21.0	-4.2	-4.1	-4.6
Number of self-reported non-cancer illnesses	0.9	1.5	3.2	-1.8	-0.8	-0.8
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.1	0.4	-0.3
Miserableness	1.7	3.0	4.6	-2.0	-0.6	-2.1
Guilty feelings	0.4	0.6	1.0	-1.0	-0.7	-0.5
Wears glasses or contact lenses	0.9	1.0	2.2	1.5	-0.4	0.9
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.3	-0.1	0.2
Hearing aid user	1.3	1.5	2.3	0.9	1.5	1.2
Mother’s age at death	1.3	1.6	4.2	2.0	0.7	0.0
Financial situation satisfaction	1.4	1.7	2.6	-1.5	-1.6	-0.6
Tinnitus: Yes, now most or all of the time	1.3	1.5	1.9	-1.0	1.2	-1.4
Commuting to job workplace: Public transport	0.8	0.9	1.0	-1.0	-0.9	1.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	-0.3	0.4
Medication: Blood pressure	2.5	4.8	8.9	-3.0	-1.4	-1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-0.8	-0.9	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	1.3	-0.7	-0.9
High cholesterol (Self-reported)	0.2	0.4	1.3	-1.1	-0.0	0.2
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.7	0.1	-0.7
Medication: Paracetamol	3.1	4.9	11.1	-3.3	-1.2	-1.4
Medication: Lisinopril	2.1	2.8	3.4	-1.5	-1.8	-1.6
Medication: Atorvastatin	0.2	0.2	0.6	0.0	0.3	0.8
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.8	0.3	0.5
Alcohol drinker status: Never	0.9	1.0	1.7	0.4	1.3	1.1
Ever smoked	1.6	2.7	4.2	-2.0	-1.3	-1.5
Basal metabolic rate	2.9	16.0	20.5	-3.0	-4.5	-4.3
Leg fat percentage (left)	2.6	9.2	14.4	-3.4	-1.4	-3.8
Arm fat-free mass (left)	2.4	12.1	16.3	-2.5	-3.7	-4.0
Number of operations (self-reported)	1.1	1.6	2.3	-1.0	-1.5	-1.2
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.5	0.6	0.1
Irritability	0.7	1.3	3.7	-0.1	1.9	-0.2
Risk taking	1.4	2.1	4.7	-2.2	0.1	-1.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.2	-0.1	-1.8	0.4
Fractured/broken bones in last 5 years	0.8	1.0	2.8	-0.5	-0.1	1.7
Age started oral contraceptive pill	0.9	1.2	2.3	1.5	-0.8	0.8
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	0.3	-0.1
Ever depressed for a whole week	2.7	3.3	4.3	1.3	2.1	2.0
Unable to work because of sickness or disability	0.7	0.9	1.7	0.2	-1.0	-1.3
Commuting to job workplace: Cycle	0.6	0.8	1.8	-0.4	-0.6	1.3
Myopia	0.1	0.2	0.4	0.7	0.2	0.4
Vascular/heart problems diagnosed by doctor	2.1	5.7	6.9	2.6	2.2	2.3
Cholesterol lowering medication	0.3	0.4	1.0	0.1	-1.0	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.8	0.7	0.9	-0.3
Pain experienced in last month	2.2	3.7	6.8	2.6	0.7	1.9
Supplements: Calcium	0.5	0.5	0.6	-0.6	0.8	-0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.3	-0.7	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.5	-0.6	-0.4
Heart disease (siblings)	4.4	5.4	8.8	-1.7	-2.1	-3.0
Alcohol drinker status: Previous	1.1	1.3	2.9	0.4	1.7	-0.9
Pack years of smoking	2.3	3.4	6.8	-1.5	-1.1	-2.6
Impedance of whole body	2.1	10.9	22.6	1.6	4.8	2.8
Leg fat mass (left)	4.7	18.2	25.8	-4.2	-3.3	-5.1
Arm predicted mass (left)	2.4	12.3	15.8	-2.4	-3.9	-4.0