Hub : Genes

C7orf10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.309 0.1131 4.3e-03 -0.007 NA 0.019 NA -0.006 0.71000 NA 7.0e-02 NA 6.4e-01
2 GTEx Nerve Tibial 0.129 0.0461 6.7e-05 0.051 NA 0.088 NA 0.087 0.00017 NA 8.3e-07 NA 9.6e-07
3 TCGA Ovarian Serous Cystadenocarcinoma 0.114 0.0510 5.7e-03 0.004 0.033 0.036 NA 0.009 0.15000 0.0027 1.7e-03 NA 8.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.1 0.4 -0.3 -0.4
Bipolar Disorder or Schizophrenia 0.2 0.4 1.0 -0.2 1.0 -0.4
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 -0.1 0.1 0.2
Depression (Nagel 2018) 1.1 1.7 3.2 1.8 0.9 1.0
Intelligence (Savage-Jansen 2018) 0.1 0.5 0.7 -0.5 -0.7 -0.8
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -0.8 -0.0 1.0
Schizophrenia (2018) 0.5 0.9 2.4 -0.6 1.5 -0.2
Schizophrenia vs Biploar Disorder 0.4 0.6 0.8 -0.6 0.9 0.7
Worry (Nagel 2018) 0.9 2.0 3.9 -2.0 -0.3 1.4
Alzheimer’s Disease (in mother) 0.5 0.6 1.2 -1.1 0.7 -0.3
Alzheimer’s Disease (in father) 1.5 1.6 2.8 -0.0 -1.4 -1.7
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 -0.9 -0.1 -0.3
Crohns Disease (2017) 1.2 2.7 4.7 -1.2 -1.4 -2.2
Irritable Bowel Disease (IBD) 1.3 3.0 3.5 -1.8 -1.9 -1.6
Ulcerative Colitis (UC) 0.7 1.3 2.3 -1.5 -1.2 -0.6
Major Depression (MDD) 0.8 0.9 2.7 -1.6 0.0 0.4
Reaction Time 1.7 3.2 5.0 2.2 1.2 1.8
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.1 0.3 -0.3 -1.1
Breast Cancer 0.4 0.9 1.8 0.8 1.3 0.4
Ovarian Cancer 0.3 0.4 0.7 0.9 0.6 -0.0
Prostate Cancer 1.6 2.3 4.5 -0.5 -2.1 -1.4
Age at First Birth 1.7 2.5 6.1 -0.3 1.1 2.5
Bipolar Disorder (2011) 2.1 2.0 4.0 2.0 1.4 -0.2
Body Mass Index (BMI) (2010) 0.6 0.8 1.3 0.1 -1.1 1.0
Coronary Artery Disease (CAD) 2.0 2.4 3.0 -1.6 1.3 1.7
Crohns Disease (2012) 1.5 2.5 4.8 -1.0 -1.3 -2.2
Mean Putamen Volume 0.1 0.1 0.1 -0.3 -0.4 0.1
Fasting Glucose 0.3 0.3 0.6 -0.2 0.8 0.7
HbA1C 0.4 0.4 1.0 -0.1 -0.6 -1.0
HDL Cholesterol 0.3 0.5 1.0 -0.8 1.0 0.0
LDL Cholesterol 0.2 0.4 0.7 -0.6 -0.8 -0.2
Lupus 0.4 0.7 1.8 0.3 0.2 1.3
Neuroticism (2016) 1.2 1.7 3.2 -1.3 -0.6 1.8
Primary Biliary Cirrhosis 0.3 0.4 0.9 -0.9 0.1 -0.5
Rheumatoid Arthritis 3.1 4.3 12.7 0.3 3.6 0.0
Schizophrenia (2014) 0.3 0.7 2.0 -0.1 1.4 0.1
Triglycerides 1.0 1.6 3.9 0.3 -2.0 -0.8
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.0 0.5 -1.0 -0.2
Ulcerative Colitis 1.5 2.2 4.5 -2.1 -1.1 -1.0
Blood Eosinophil Count 0.9 7.1 11.1 -1.6 3.3 2.8
Blood Platelet Count 0.1 1.7 2.3 1.5 0.7 -1.5
Blood Red Count 0.1 0.9 2.3 -0.5 0.3 1.5
Blood White Count 0.6 4.7 7.2 -0.4 2.6 2.7
Heel T-Score 0.6 5.2 7.2 2.7 2.3 -1.7
BMI 0.5 3.1 5.0 2.2 -0.3 -2.1
Height 0.5 10.5 26.4 5.1 -0.7 -2.1
Waist Hip Ratio (WHR) 0.1 0.6 1.1 -1.1 -0.6 0.6
Systolic Blood Pressure 0.2 0.8 1.5 1.2 -1.0 0.2
Smoking Status 0.8 1.9 5.2 -2.3 -0.2 0.6
Allergy or Eczema 0.7 2.0 3.4 1.6 1.8 -0.3
Cardiovascular Disease 0.3 1.1 3.0 0.2 0.4 1.7
Hypothyroidism (self reported) 2.0 4.5 8.1 2.9 2.3 -0.5
Respiratory disease 0.2 0.5 0.8 -0.7 -0.1 0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 -0.1 -0.7 -0.8
Lung FEV1/FVC ratio 0.1 0.4 1.0 -0.3 -0.0 1.0
Lung FVC 0.1 0.6 1.1 -0.0 0.8 -1.0
Neuroticism 1.0 2.3 3.5 -1.9 -0.4 1.8
Chronotype (morning person) 1.4 3.1 3.7 1.7 -1.7 -1.9
Hair Pigment 0.2 4.6 13.4 0.2 -0.6 -3.7
Tanning 0.1 1.2 2.9 -0.5 -0.7 -1.7
Hand grip strength (left) 0.8 2.2 5.2 2.3 -0.6 -1.1
Number of treatments/medications taken 0.5 0.9 2.4 0.3 0.4 1.6
Average weekly spirits intake 0.5 0.6 1.8 -0.3 1.4 0.1
Sensitivity / hurt feelings 0.4 0.7 1.0 -1.0 0.5 1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.9 0.1 0.2 1.0
Hearing difficulty/problems: Yes 0.6 0.9 1.6 -0.1 -1.0 1.3
Relative age of first facial hair 1.1 2.2 3.8 0.5 -1.9 -1.6
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 1.8 1.1 0.9 -1.4
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.3 -0.9 -0.6 1.8
Ever had hysterectomy (womb removed) 0.9 1.0 1.2 -1.1 0.8 1.1
Systolic blood pressure, automated reading 0.6 1.7 3.2 1.1 -1.8 -0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.9 0.8 0.9 -0.1
Angina 0.2 0.3 0.8 -0.9 -0.1 0.1
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.2 -0.8 0.5
Vitamin and mineral supplements 2.1 2.8 5.4 -1.1 -2.3 -1.4
Supplements: Zinc 1.4 1.5 3.8 0.8 2.0 0.2
Medication: Co-codamol 0.4 0.5 1.0 0.4 0.6 1.0
Medication: Metformin 1.3 1.8 3.8 -0.2 -1.2 -2.0
Diabetes (father) 0.4 0.5 1.0 -0.2 -1.0 0.7
Diabetes (mother) 1.3 1.7 3.4 1.0 -1.9 -0.8
Severe depression (siblings) 0.6 0.6 1.0 -0.4 -0.9 -1.0
Pack years adult smoking proportion 0.3 0.5 1.0 1.0 0.2 -0.7
Impedance of leg (right) 0.1 0.6 1.1 -0.6 -1.1 0.5
Leg fat-free mass (left) 1.1 5.6 8.6 2.6 -1.0 -2.9
Trunk fat percentage 1.1 4.3 7.9 1.9 -1.2 -2.8
Hand grip strength (right) 0.4 1.2 2.4 1.5 -0.4 -0.9
Townsend deprivation index at recruitment 0.2 0.3 0.6 -0.8 0.1 0.4
Current tobacco smoking 0.6 1.0 2.5 -1.6 -0.4 -0.7
Average weekly fortified wine intake 0.0 0.0 0.1 -0.1 -0.2 0.2
Maternal smoking around birth 0.6 0.8 2.0 0.7 -0.2 -1.4
Fed-up feelings 0.2 0.3 0.7 -0.8 -0.3 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.4 1.2 0.3 0.3
Relative age voice broke 0.2 0.3 0.5 -0.4 -0.7 0.4
Taking other prescription medications 0.2 0.3 0.9 -0.9 -0.0 0.4
Age when periods started (menarche) 0.2 0.5 0.9 0.7 -1.0 -0.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.4 0.7 0.2 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 3.5 1.9 1.5 -1.1
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 6.7 2.6 0.1 -0.6
Qualifications: CSEs or equivalent 0.2 0.2 0.5 -0.7 0.4 -0.3
Serious illness, injury or assault to yourself 0.5 0.6 1.1 -1.0 -0.9 0.3
High blood pressure 0.2 0.6 1.6 0.3 0.2 1.3
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.1 0.4 1.5 0.2
Multivitamins +/- minerals 1.7 2.2 3.4 -0.2 1.8 1.8
Stomach or abdominal pain in last month 0.7 0.9 2.6 -1.6 0.0 0.4
Supplements: Glucosamine 1.8 2.4 2.8 -1.5 1.4 1.7
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 3.8 -1.6 0.6 1.9
Medication: Atenolol 0.1 0.1 0.2 -0.1 0.4 0.5
Medication: Levothyroxine sodium 0.6 1.0 2.0 0.6 1.4 0.9
Sitting height 0.4 2.8 4.7 2.2 -0.4 -1.8
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 -0.8 0.2 0.8
High blood pressure (mother) 0.2 0.3 0.5 -0.7 -0.6 -0.1
Body mass index (BMI) 0.7 3.0 6.1 1.6 -0.8 -2.5
Impedance of leg (left) 0.1 0.4 0.4 -0.5 -0.6 0.7
Leg predicted mass (left) 1.0 5.4 8.3 2.6 -1.0 -2.9
Trunk fat mass 1.6 6.7 12.5 2.3 -1.6 -3.5
Waist circumference 1.4 5.1 9.9 1.7 -1.6 -3.1
Number of incorrect matches in round 0.2 0.3 0.9 1.0 0.0 0.0
Past tobacco smoking 2.4 4.3 9.3 3.0 1.7 -0.8
Alcohol usually taken with meals 0.5 0.8 1.0 -0.7 0.9 -1.0
Nervous feelings 0.7 1.4 2.6 -1.6 0.1 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 1.1 -0.2 -0.2 1.0
Hearing difficulty/problems with background noise 0.7 1.1 1.8 -0.7 -1.4 1.1
Hair/balding pattern: Pattern 2 0.6 0.8 2.1 -0.5 1.4 -0.3
Had menopause 0.3 0.3 0.9 -1.0 -0.3 0.2
Had other major operations 0.6 0.7 1.3 -0.2 -0.9 -1.1
Forced vital capacity (FVC) 0.7 2.7 5.0 1.3 -1.2 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.0 0.6 1.4 -0.7
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 1.5 0.8 1.2 0.8
Qualifications: None of the above 0.0 0.1 0.2 -0.1 0.4 -0.3
Financial difficulties in last 2 years 0.2 0.3 0.5 0.7 0.4 -0.3
Mouth/teeth dental problems 0.2 0.3 0.4 0.6 0.5 0.4
Heart attack 3.5 4.5 8.8 0.3 3.0 2.1
Allergy 0.6 1.4 3.2 -0.8 -1.8 -0.6
Pain all over the body in last month 0.5 0.5 1.0 1.0 -0.6 0.2
Diabetes (self-reported) 0.3 0.4 0.7 -0.4 -0.8 -0.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.0 0.2 0.9 1.0
Medication: Ramipril 0.5 0.6 1.1 -0.6 -1.0 -0.7
Medication: Simvastatin 0.1 0.2 0.5 -0.0 0.7 0.4
Fluid intelligence score 0.4 0.8 2.1 -1.5 -0.5 -0.3
Illnesses of siblings 0.6 0.9 1.4 1.0 0.6 -1.2
Neuroticism score 1.6 3.4 8.4 -2.9 -1.1 0.9
Weight 1.7 8.2 13.9 3.0 -1.3 -3.7
Impedance of arm (right) 0.0 0.0 0.0 -0.2 0.1 0.1
Arm fat percentage (right) 0.7 2.6 5.0 1.6 -0.5 -2.2
Trunk fat-free mass 0.5 3.0 4.8 1.6 -1.2 -2.2
Hip circumference 1.7 7.5 11.9 2.7 -1.8 -3.5
Time employed in main current job 1.8 2.0 3.1 -1.7 0.3 1.8
Alcohol intake versus 10 years previously 0.3 0.4 1.0 1.0 0.3 0.3
Father’s age at death 0.7 1.0 1.7 0.5 -1.0 -1.3
Worrier / anxious feelings 2.8 5.3 8.4 -2.9 -2.4 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.5 0.5 0.9
Falls in the last year 1.2 1.6 2.8 1.7 -0.2 -1.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.4 -0.5 0.1
Number of live births 0.2 0.2 0.5 0.7 -0.4 0.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 3.9 1.2 -1.3 -2.0
Pulse rate 1.5 2.4 3.4 -1.1 -1.7 -1.8
Happiness 0.6 0.7 1.0 0.7 0.9 -1.0
Noisy workplace 1.3 1.6 4.8 2.2 0.3 0.3
Qualifications: A levels/AS levels or equivalent 1.0 2.3 4.0 2.0 1.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.2 -1.2 -0.7 -1.5
Mouth/teeth dental problems: Dentures 0.5 0.9 1.6 -1.3 0.2 1.0
Asthma 0.2 0.4 0.5 -0.7 -0.5 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.4 0.6 0.8 0.6 -0.6
Medication: Cholesterol lowering 0.7 1.1 3.1 -1.7 -0.5 0.1
Depression (self-reported) 0.2 0.2 0.3 -0.2 0.5 0.6
Medication: Lansoprazole 0.4 0.5 0.9 -1.0 -0.7 -0.3
Prospective memory result 0.6 0.7 1.2 0.3 0.9 1.1
Lung cancer (father) 0.4 0.5 1.1 -0.2 -0.6 1.0
Illnesses of mother 0.8 1.0 2.4 1.6 -0.2 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 3.0 1.7 -0.9 -0.9
Pulse wave Arterial Stiffness index 0.4 0.5 0.7 -0.6 0.6 0.8
Impedance of arm (left) 0.0 0.1 0.2 -0.0 0.4 0.2
Arm fat mass (right) 1.0 4.0 6.2 2.2 -1.0 -2.5
Trunk predicted mass 0.5 3.1 4.9 1.6 -1.3 -2.2
Standing height 0.6 6.0 9.9 3.1 -1.2 -2.6
Length of working week for main job 0.3 0.3 0.4 -0.6 0.3 -0.6
Exposure to tobacco smoke at home 0.8 1.0 1.0 -1.0 1.0 0.9
Breastfed as a baby 2.9 3.6 7.6 -0.6 1.7 2.8
Tense / ‘highly strung’ 0.5 0.8 0.9 -0.8 1.0 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.9 -0.4 1.0 0.7
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.0 -0.3 -0.4
Birth weight of first child 0.1 0.2 0.4 0.1 -0.3 -0.6
Peak expiratory flow (PEF) 1.4 3.2 5.9 0.9 -1.7 -2.4
Pulse wave reflection index 2.1 2.6 6.4 0.6 2.5 1.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.2 1.5 0.1 -0.4
Loud music exposure frequency 0.2 0.2 0.4 0.5 0.2 -0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.2 1.1 0.4 -0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.4 -0.8 -0.4 -1.2
Blood clot in the leg (DVT) 0.2 0.2 0.6 0.2 0.3 0.8
Medication: Paracetamol 0.5 0.8 1.1 -1.1 -0.9 0.8
Headache pain in last month 0.6 1.0 2.2 -0.6 1.5 0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.9 1.3 1.4 0.2
Glaucoma (self-reported) 0.8 1.0 1.6 1.2 -0.2 -1.3
Gout (self-reported) 0.4 0.5 1.2 0.5 1.1 -0.3
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 5.5 2.3 2.3 0.2
Medication: Amlodipine 0.5 0.8 2.1 -0.3 1.5 0.2
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 -0.1 -0.2 -0.3
Birth weight 0.0 0.0 0.1 0.1 0.3 -0.1
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.6 -0.6 0.8 0.6
High blood pressure (siblings) 0.1 0.1 0.3 -0.6 0.3 0.0
Forced vital capacity (FVC), Best measure 0.6 2.1 5.0 2.2 -0.4 -1.1
Body fat percentage 1.1 4.5 8.6 1.9 -1.1 -2.9
Leg fat percentage (right) 1.2 4.4 8.8 1.6 -1.3 -3.0
Arm fat-free mass (right) 0.7 3.6 5.6 1.4 -1.8 -2.4
Exposure to tobacco smoke outside home 0.1 0.2 0.3 0.5 0.5 0.2
Comparative body size at age 10 0.1 0.2 0.3 0.4 0.1 -0.6
Number of full brothers 1.7 2.2 4.4 0.1 -2.1 -1.4
Worry too long after embarrassment 1.1 1.8 2.7 -1.4 -1.7 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.2 -1.5 0.6 0.9
Wheeze or whistling in the chest in last year 0.6 1.0 1.5 -1.2 0.9 -0.9
Number of children fathered 1.2 1.4 2.3 1.1 -0.9 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 1.9 -1.4 1.0 0.6
Age at first live birth 0.3 0.6 1.1 -0.2 -1.1 -0.7
Pulse wave peak to peak time 0.5 0.6 0.9 0.6 -0.8 -0.9
Health satisfaction 1.1 1.4 3.3 0.9 1.8 -0.4
Shortness of breath walking on level ground 1.2 1.4 2.0 1.3 1.4 0.7
Qualifications: College or University degree 0.1 0.5 0.8 0.9 0.6 -0.5
Eye problems/disorders: None of the above 1.2 1.4 2.0 -0.8 1.4 1.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.6 -0.7 -0.1 -1.3
Emphysema/chronic bronchitis 2.1 2.4 3.4 -0.6 1.8 1.8
Medication for pain relief, constipation, heartburn 0.5 0.8 1.4 1.2 -0.3 -1.0
Neck or shoulder pain in last month 0.7 0.9 2.3 0.7 1.5 0.0
Medication: Blood pressure 0.1 0.2 0.4 -0.0 -0.6 0.3
Angina (self-reported) 0.3 0.3 1.0 -1.0 -0.0 0.0
Migraine (self-reported) 1.0 1.3 1.9 -1.4 -0.5 1.2
Medication: Ibuprofen 0.9 1.1 1.6 1.3 -0.4 -1.2
Medication: Allopurinol 0.4 0.6 1.6 -0.1 1.2 0.4
Medication: Omeprazole 1.0 1.2 2.4 -0.5 1.0 1.6
Medication: Seretide 50 evohaler 1.1 1.3 1.9 -0.9 1.0 1.4
Mean time to correctly identify matches 1.6 3.0 6.7 0.9 1.2 2.6
Heart disease (mother) 1.0 1.2 1.5 -1.2 -1.1 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 0.9 -0.1 -0.0
Whole body fat mass 1.4 5.7 9.7 2.2 -1.6 -3.1
Leg fat mass (right) 1.7 6.6 11.2 2.4 -1.7 -3.4
Arm predicted mass (right) 0.8 4.0 5.5 1.9 -1.8 -2.4
Pulse rate, automated reading 2.2 7.2 11.5 -1.7 -3.4 -2.7
Alcohol intake frequency. 0.3 0.7 2.1 1.4 -0.1 -0.2
Comparative height size at age 10 1.1 6.1 16.5 4.1 0.9 -1.0
Number of full sisters 0.1 0.1 0.2 -0.1 -0.4 0.2
Suffer from ‘nerves’ 2.4 3.7 8.8 -3.0 -1.1 1.0
Overall health rating 0.1 0.2 0.6 -0.8 -0.3 -0.0
Chest pain or discomfort 0.3 0.4 0.5 0.6 -0.7 -0.5
Had major operations 0.2 0.2 0.5 -0.1 0.1 0.7
Age at last live birth 0.1 0.1 0.2 0.2 0.4 -0.4
Family relationship satisfaction 0.8 1.0 2.6 -0.5 1.6 -0.3
Leg pain on walking 2.2 2.7 6.5 2.5 1.3 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.3 -0.4 -1.5 0.2
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.0 -1.2 -1.4 0.0
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 5.6 2.4 1.0 0.3
Medication: Aspirin 0.7 0.9 1.7 -1.0 1.3 0.3
Supplements: Vitamin C 3.1 3.6 6.1 2.1 2.5 0.6
Knee pain experienced in last month 0.2 0.3 0.8 -0.3 0.0 0.9
Hypertension (Self-reported) 0.4 1.1 2.5 0.8 0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.9 -1.0 0.4 -0.0
Illnesses of father: Heart disease 0.9 1.2 2.2 -0.5 1.5 1.1
Illnesses of siblings: Diabetes 0.5 0.6 1.0 -0.8 -0.4 1.0
Smoking status: Previous 2.1 3.1 5.0 -2.2 -2.0 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.4 0.2 -1.0 -1.5
Whole body fat-free mass 0.7 4.3 6.8 2.2 -1.1 -2.6
Leg fat-free mass (right) 0.9 4.9 7.8 2.8 -0.4 -2.6
Arm fat percentage (left) 0.8 3.2 6.1 1.8 -0.4 -2.5
Average weekly red wine intake 0.8 1.2 2.3 -0.3 1.5 1.1
Handedness (chirality/laterality): Left-handed 1.7 2.0 4.0 -1.1 0.9 2.0
Mood swings 0.3 0.5 0.9 -0.9 -0.0 0.9
Loneliness, isolation 0.3 0.5 1.0 0.1 1.0 -0.6
Long-standing illness, disability or infirmity 1.0 1.5 4.2 0.5 -0.4 -2.0
Ever had bowel cancer screening 2.6 3.0 6.1 -1.1 1.3 2.5
Diabetes diagnosed by doctor 0.1 0.1 0.2 0.1 -0.5 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.6 0.5 1.3 1.1
Friendships satisfaction 1.0 1.3 2.0 -1.4 1.3 0.2
Qualifications: nursing, teaching 0.5 0.8 2.1 1.4 0.3 -0.3
Commuting to job workplace: Walk 0.1 0.2 0.3 -0.5 0.4 0.2
Eye problems/disorders: Cataract 0.6 0.7 1.3 -0.8 -0.0 1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.1 1.0 -0.4 -0.6
Medication for cholesterol 1.9 2.9 7.2 -0.2 -1.1 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.1 0.0 -0.4 -0.2
Back pain experienced in last month 0.8 1.2 2.8 -1.7 0.5 -0.8
Mineral and other dietary supplements 2.4 3.2 4.8 -0.5 -2.2 -2.1
Breast cancer (self-reported) 0.1 0.2 0.3 -0.1 -0.4 0.5
Asthma (self-reported) 0.2 0.5 1.2 -1.1 -0.4 -0.2
Osteoporosis (self-reported) 1.2 1.5 2.2 -1.5 -1.4 -0.5
Osteoarthritis (self-reported) 0.4 0.5 1.2 -0.1 -0.6 -1.1
Medication: Aspirin 0.6 0.7 1.2 -1.1 0.9 -0.3
Medication: Gliclazide 0.6 0.7 1.2 1.1 0.3 -0.9
Illnesses of father: None of the above (group 1) 0.0 0.1 0.1 -0.1 0.4 0.2
Smoking status: Current 0.6 0.9 2.3 -1.5 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.8 0.9 -0.3 -0.2
Whole body water mass 0.7 4.2 6.7 2.1 -1.2 -2.6
Leg predicted mass (right) 0.9 5.0 8.0 2.8 -0.4 -2.6
Arm fat mass (left) 1.0 4.2 7.4 2.0 -1.0 -2.7
Number of self-reported non-cancer illnesses 0.2 0.3 0.5 -0.6 -0.4 0.7
Average weekly champagne plus white wine intake 1.1 1.5 2.4 1.4 0.3 -1.6
Miserableness 0.6 1.1 3.0 -1.7 0.4 -0.2
Guilty feelings 0.2 0.3 0.5 0.7 0.5 0.5
Wears glasses or contact lenses 2.0 2.3 5.7 2.4 0.4 -1.0
Ever taken oral contraceptive pill 1.5 1.7 3.9 0.5 2.0 -1.0
Hearing aid user 0.9 1.0 2.2 -1.5 -0.5 0.8
Mother’s age at death 0.2 0.2 0.4 0.7 0.4 0.2
Financial situation satisfaction 0.5 0.6 1.0 1.0 0.8 -0.4
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.8 0.4 -0.3 1.7
Commuting to job workplace: Public transport 0.4 0.5 0.7 0.6 -0.6 0.8
Eye problems/disorders: Glaucoma 0.4 0.5 0.7 0.8 -0.4 -0.8
Medication: Blood pressure 2.6 4.9 10.0 -0.3 2.2 3.2
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 0.8 0.1 0.2
Supplements: Fish oil (including cod liver oil) 2.0 2.6 5.3 0.4 1.6 2.3
High cholesterol (Self-reported) 1.1 2.0 3.7 -1.5 0.2 1.9
Medication: Bendroflumethiazide 1.1 1.7 4.0 0.5 0.9 2.0
Medication: Paracetamol 0.2 0.3 0.6 0.8 -0.5 0.4
Medication: Lisinopril 0.2 0.3 0.4 -0.6 -0.6 -0.3
Medication: Atorvastatin 0.6 0.8 2.2 0.0 0.5 1.5
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.3 -0.1 -0.5
Alcohol drinker status: Never 0.5 0.6 1.8 1.4 -0.2 -0.1
Ever smoked 2.4 4.2 9.2 -3.0 -1.8 0.3
Basal metabolic rate 0.9 5.2 7.9 2.5 -1.1 -2.8
Leg fat percentage (left) 1.0 3.7 7.8 1.6 -0.9 -2.8
Arm fat-free mass (left) 0.9 4.6 6.9 1.9 -1.8 -2.6
Number of operations (self-reported) 0.1 0.2 0.4 0.3 -0.3 -0.6
Average weekly beer plus cider intake 0.7 1.1 2.4 -0.9 -1.6 -0.2
Irritability 0.3 0.5 0.7 -0.9 0.1 0.8
Risk taking 0.7 1.0 2.2 0.1 1.5 0.9
Ever had prostate specific antigen (PSA) test 1.9 2.1 5.4 -2.3 0.6 0.8
Fractured/broken bones in last 5 years 1.2 1.6 2.8 -1.7 -0.6 1.3
Age started oral contraceptive pill 0.5 0.7 1.1 -0.3 1.0 0.9
Diastolic blood pressure, automated reading 0.5 1.5 2.6 1.6 -0.2 -1.3
Ever depressed for a whole week 0.9 1.1 1.6 0.4 1.2 1.3
Unable to work because of sickness or disability 0.0 0.0 0.1 0.3 -0.0 -0.2
Commuting to job workplace: Cycle 0.7 0.9 2.4 -1.5 -0.3 0.5
Myopia 3.7 5.4 12.5 -0.8 -1.8 -3.5
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.7 0.0 -0.4 -1.6
Cholesterol lowering medication 1.3 2.0 3.5 0.4 1.5 1.9
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 4.5 -0.9 0.8 2.1
Pain experienced in last month 1.0 1.7 4.6 2.1 -0.5 0.5
Supplements: Calcium 0.3 0.3 0.7 -0.3 0.8 -0.2
Basal cell carcinoma (self-reported) 0.9 1.1 2.0 -1.4 -1.1 0.3
Heart attack/myocardial infarction (self-reported) 3.1 4.0 8.3 0.4 2.9 1.8
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.0 0.1 0.4
Heart disease (siblings) 1.0 1.2 3.6 0.2 -0.2 1.9
Alcohol drinker status: Previous 0.4 0.4 1.0 0.3 0.5 1.0
Pack years of smoking 0.3 0.4 0.9 0.9 0.3 -0.5
Impedance of whole body 0.0 0.2 0.3 -0.4 0.1 0.6
Leg fat mass (left) 1.5 5.9 9.7 2.5 -1.4 -3.1
Arm predicted mass (left) 0.7 3.8 5.4 1.8 -1.7 -2.3