Hub : Genes

C7orf10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.309	0.1131	4.3e-03	-0.007	NA	0.019	NA	-0.006	0.71000	NA	7.0e-02	NA	6.4e-01
2	GTEx	Nerve Tibial	0.129	0.0461	6.7e-05	0.051	NA	0.088	NA	0.087	0.00017	NA	8.3e-07	NA	9.6e-07
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.114	0.0510	5.7e-03	0.004	0.033	0.036	NA	0.009	0.15000	0.0027	1.7e-03	NA	8.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.1	0.4	-0.3	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.2	1.0	-0.4
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.1	0.2
Depression (Nagel 2018)	1.1	1.7	3.2	1.8	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.5	0.7	-0.5	-0.7	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-0.8	-0.0	1.0
Schizophrenia (2018)	0.5	0.9	2.4	-0.6	1.5	-0.2
Schizophrenia vs Biploar Disorder	0.4	0.6	0.8	-0.6	0.9	0.7
Worry (Nagel 2018)	0.9	2.0	3.9	-2.0	-0.3	1.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	-1.1	0.7	-0.3
Alzheimer’s Disease (in father)	1.5	1.6	2.8	-0.0	-1.4	-1.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.9	-0.1	-0.3
Crohns Disease (2017)	1.2	2.7	4.7	-1.2	-1.4	-2.2
Irritable Bowel Disease (IBD)	1.3	3.0	3.5	-1.8	-1.9	-1.6
Ulcerative Colitis (UC)	0.7	1.3	2.3	-1.5	-1.2	-0.6
Major Depression (MDD)	0.8	0.9	2.7	-1.6	0.0	0.4
Reaction Time	1.7	3.2	5.0	2.2	1.2	1.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.1	0.3	-0.3	-1.1
Breast Cancer	0.4	0.9	1.8	0.8	1.3	0.4
Ovarian Cancer	0.3	0.4	0.7	0.9	0.6	-0.0
Prostate Cancer	1.6	2.3	4.5	-0.5	-2.1	-1.4
Age at First Birth	1.7	2.5	6.1	-0.3	1.1	2.5
Bipolar Disorder (2011)	2.1	2.0	4.0	2.0	1.4	-0.2
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	0.1	-1.1	1.0
Coronary Artery Disease (CAD)	2.0	2.4	3.0	-1.6	1.3	1.7
Crohns Disease (2012)	1.5	2.5	4.8	-1.0	-1.3	-2.2
Mean Putamen Volume	0.1	0.1	0.1	-0.3	-0.4	0.1
Fasting Glucose	0.3	0.3	0.6	-0.2	0.8	0.7
HbA1C	0.4	0.4	1.0	-0.1	-0.6	-1.0
HDL Cholesterol	0.3	0.5	1.0	-0.8	1.0	0.0
LDL Cholesterol	0.2	0.4	0.7	-0.6	-0.8	-0.2
Lupus	0.4	0.7	1.8	0.3	0.2	1.3
Neuroticism (2016)	1.2	1.7	3.2	-1.3	-0.6	1.8
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.9	0.1	-0.5
Rheumatoid Arthritis	3.1	4.3	12.7	0.3	3.6	0.0
Schizophrenia (2014)	0.3	0.7	2.0	-0.1	1.4	0.1
Triglycerides	1.0	1.6	3.9	0.3	-2.0	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	0.5	-1.0	-0.2
Ulcerative Colitis	1.5	2.2	4.5	-2.1	-1.1	-1.0
Blood Eosinophil Count	0.9	7.1	11.1	-1.6	3.3	2.8
Blood Platelet Count	0.1	1.7	2.3	1.5	0.7	-1.5
Blood Red Count	0.1	0.9	2.3	-0.5	0.3	1.5
Blood White Count	0.6	4.7	7.2	-0.4	2.6	2.7
Heel T-Score	0.6	5.2	7.2	2.7	2.3	-1.7
BMI	0.5	3.1	5.0	2.2	-0.3	-2.1
Height	0.5	10.5	26.4	5.1	-0.7	-2.1
Waist Hip Ratio (WHR)	0.1	0.6	1.1	-1.1	-0.6	0.6
Systolic Blood Pressure	0.2	0.8	1.5	1.2	-1.0	0.2
Smoking Status	0.8	1.9	5.2	-2.3	-0.2	0.6
Allergy or Eczema	0.7	2.0	3.4	1.6	1.8	-0.3
Cardiovascular Disease	0.3	1.1	3.0	0.2	0.4	1.7
Hypothyroidism (self reported)	2.0	4.5	8.1	2.9	2.3	-0.5
Respiratory disease	0.2	0.5	0.8	-0.7	-0.1	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.1	-0.7	-0.8
Lung FEV1/FVC ratio	0.1	0.4	1.0	-0.3	-0.0	1.0
Lung FVC	0.1	0.6	1.1	-0.0	0.8	-1.0
Neuroticism	1.0	2.3	3.5	-1.9	-0.4	1.8
Chronotype (morning person)	1.4	3.1	3.7	1.7	-1.7	-1.9
Hair Pigment	0.2	4.6	13.4	0.2	-0.6	-3.7
Tanning	0.1	1.2	2.9	-0.5	-0.7	-1.7
Hand grip strength (left)	0.8	2.2	5.2	2.3	-0.6	-1.1
Number of treatments/medications taken	0.5	0.9	2.4	0.3	0.4	1.6
Average weekly spirits intake	0.5	0.6	1.8	-0.3	1.4	0.1
Sensitivity / hurt feelings	0.4	0.7	1.0	-1.0	0.5	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.1	0.2	1.0
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-0.1	-1.0	1.3
Relative age of first facial hair	1.1	2.2	3.8	0.5	-1.9	-1.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.8	1.1	0.9	-1.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.3	-0.9	-0.6	1.8
Ever had hysterectomy (womb removed)	0.9	1.0	1.2	-1.1	0.8	1.1
Systolic blood pressure, automated reading	0.6	1.7	3.2	1.1	-1.8	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	0.8	0.9	-0.1
Angina	0.2	0.3	0.8	-0.9	-0.1	0.1
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.2	-0.8	0.5
Vitamin and mineral supplements	2.1	2.8	5.4	-1.1	-2.3	-1.4
Supplements: Zinc	1.4	1.5	3.8	0.8	2.0	0.2
Medication: Co-codamol	0.4	0.5	1.0	0.4	0.6	1.0
Medication: Metformin	1.3	1.8	3.8	-0.2	-1.2	-2.0
Diabetes (father)	0.4	0.5	1.0	-0.2	-1.0	0.7
Diabetes (mother)	1.3	1.7	3.4	1.0	-1.9	-0.8
Severe depression (siblings)	0.6	0.6	1.0	-0.4	-0.9	-1.0
Pack years adult smoking proportion	0.3	0.5	1.0	1.0	0.2	-0.7
Impedance of leg (right)	0.1	0.6	1.1	-0.6	-1.1	0.5
Leg fat-free mass (left)	1.1	5.6	8.6	2.6	-1.0	-2.9
Trunk fat percentage	1.1	4.3	7.9	1.9	-1.2	-2.8
Hand grip strength (right)	0.4	1.2	2.4	1.5	-0.4	-0.9
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.8	0.1	0.4
Current tobacco smoking	0.6	1.0	2.5	-1.6	-0.4	-0.7
Average weekly fortified wine intake	0.0	0.0	0.1	-0.1	-0.2	0.2
Maternal smoking around birth	0.6	0.8	2.0	0.7	-0.2	-1.4
Fed-up feelings	0.2	0.3	0.7	-0.8	-0.3	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	1.2	0.3	0.3
Relative age voice broke	0.2	0.3	0.5	-0.4	-0.7	0.4
Taking other prescription medications	0.2	0.3	0.9	-0.9	-0.0	0.4
Age when periods started (menarche)	0.2	0.5	0.9	0.7	-1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	0.7	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	3.5	1.9	1.5	-1.1
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.7	2.6	0.1	-0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.7	0.4	-0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-1.0	-0.9	0.3
High blood pressure	0.2	0.6	1.6	0.3	0.2	1.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	0.4	1.5	0.2
Multivitamins +/- minerals	1.7	2.2	3.4	-0.2	1.8	1.8
Stomach or abdominal pain in last month	0.7	0.9	2.6	-1.6	0.0	0.4
Supplements: Glucosamine	1.8	2.4	2.8	-1.5	1.4	1.7
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	3.8	-1.6	0.6	1.9
Medication: Atenolol	0.1	0.1	0.2	-0.1	0.4	0.5
Medication: Levothyroxine sodium	0.6	1.0	2.0	0.6	1.4	0.9
Sitting height	0.4	2.8	4.7	2.2	-0.4	-1.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	-0.8	0.2	0.8
High blood pressure (mother)	0.2	0.3	0.5	-0.7	-0.6	-0.1
Body mass index (BMI)	0.7	3.0	6.1	1.6	-0.8	-2.5
Impedance of leg (left)	0.1	0.4	0.4	-0.5	-0.6	0.7
Leg predicted mass (left)	1.0	5.4	8.3	2.6	-1.0	-2.9
Trunk fat mass	1.6	6.7	12.5	2.3	-1.6	-3.5
Waist circumference	1.4	5.1	9.9	1.7	-1.6	-3.1
Number of incorrect matches in round	0.2	0.3	0.9	1.0	0.0	0.0
Past tobacco smoking	2.4	4.3	9.3	3.0	1.7	-0.8
Alcohol usually taken with meals	0.5	0.8	1.0	-0.7	0.9	-1.0
Nervous feelings	0.7	1.4	2.6	-1.6	0.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.1	-0.2	-0.2	1.0
Hearing difficulty/problems with background noise	0.7	1.1	1.8	-0.7	-1.4	1.1
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	-0.5	1.4	-0.3
Had menopause	0.3	0.3	0.9	-1.0	-0.3	0.2
Had other major operations	0.6	0.7	1.3	-0.2	-0.9	-1.1
Forced vital capacity (FVC)	0.7	2.7	5.0	1.3	-1.2	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.0	0.6	1.4	-0.7
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.5	0.8	1.2	0.8
Qualifications: None of the above	0.0	0.1	0.2	-0.1	0.4	-0.3
Financial difficulties in last 2 years	0.2	0.3	0.5	0.7	0.4	-0.3
Mouth/teeth dental problems	0.2	0.3	0.4	0.6	0.5	0.4
Heart attack	3.5	4.5	8.8	0.3	3.0	2.1
Allergy	0.6	1.4	3.2	-0.8	-1.8	-0.6
Pain all over the body in last month	0.5	0.5	1.0	1.0	-0.6	0.2
Diabetes (self-reported)	0.3	0.4	0.7	-0.4	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	0.2	0.9	1.0
Medication: Ramipril	0.5	0.6	1.1	-0.6	-1.0	-0.7
Medication: Simvastatin	0.1	0.2	0.5	-0.0	0.7	0.4
Fluid intelligence score	0.4	0.8	2.1	-1.5	-0.5	-0.3
Illnesses of siblings	0.6	0.9	1.4	1.0	0.6	-1.2
Neuroticism score	1.6	3.4	8.4	-2.9	-1.1	0.9
Weight	1.7	8.2	13.9	3.0	-1.3	-3.7
Impedance of arm (right)	0.0	0.0	0.0	-0.2	0.1	0.1
Arm fat percentage (right)	0.7	2.6	5.0	1.6	-0.5	-2.2
Trunk fat-free mass	0.5	3.0	4.8	1.6	-1.2	-2.2
Hip circumference	1.7	7.5	11.9	2.7	-1.8	-3.5
Time employed in main current job	1.8	2.0	3.1	-1.7	0.3	1.8
Alcohol intake versus 10 years previously	0.3	0.4	1.0	1.0	0.3	0.3
Father’s age at death	0.7	1.0	1.7	0.5	-1.0	-1.3
Worrier / anxious feelings	2.8	5.3	8.4	-2.9	-2.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	0.5	0.5	0.9
Falls in the last year	1.2	1.6	2.8	1.7	-0.2	-1.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.4	-0.5	0.1
Number of live births	0.2	0.2	0.5	0.7	-0.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.9	1.2	-1.3	-2.0
Pulse rate	1.5	2.4	3.4	-1.1	-1.7	-1.8
Happiness	0.6	0.7	1.0	0.7	0.9	-1.0
Noisy workplace	1.3	1.6	4.8	2.2	0.3	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.0	2.0	1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.2	-1.2	-0.7	-1.5
Mouth/teeth dental problems: Dentures	0.5	0.9	1.6	-1.3	0.2	1.0
Asthma	0.2	0.4	0.5	-0.7	-0.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	0.6	0.8	0.6	-0.6
Medication: Cholesterol lowering	0.7	1.1	3.1	-1.7	-0.5	0.1
Depression (self-reported)	0.2	0.2	0.3	-0.2	0.5	0.6
Medication: Lansoprazole	0.4	0.5	0.9	-1.0	-0.7	-0.3
Prospective memory result	0.6	0.7	1.2	0.3	0.9	1.1
Lung cancer (father)	0.4	0.5	1.1	-0.2	-0.6	1.0
Illnesses of mother	0.8	1.0	2.4	1.6	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.0	1.7	-0.9	-0.9
Pulse wave Arterial Stiffness index	0.4	0.5	0.7	-0.6	0.6	0.8
Impedance of arm (left)	0.0	0.1	0.2	-0.0	0.4	0.2
Arm fat mass (right)	1.0	4.0	6.2	2.2	-1.0	-2.5
Trunk predicted mass	0.5	3.1	4.9	1.6	-1.3	-2.2
Standing height	0.6	6.0	9.9	3.1	-1.2	-2.6
Length of working week for main job	0.3	0.3	0.4	-0.6	0.3	-0.6
Exposure to tobacco smoke at home	0.8	1.0	1.0	-1.0	1.0	0.9
Breastfed as a baby	2.9	3.6	7.6	-0.6	1.7	2.8
Tense / ‘highly strung’	0.5	0.8	0.9	-0.8	1.0	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	-0.4	1.0	0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.0	-0.3	-0.4
Birth weight of first child	0.1	0.2	0.4	0.1	-0.3	-0.6
Peak expiratory flow (PEF)	1.4	3.2	5.9	0.9	-1.7	-2.4
Pulse wave reflection index	2.1	2.6	6.4	0.6	2.5	1.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	1.5	0.1	-0.4
Loud music exposure frequency	0.2	0.2	0.4	0.5	0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	1.1	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	-0.8	-0.4	-1.2
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.2	0.3	0.8
Medication: Paracetamol	0.5	0.8	1.1	-1.1	-0.9	0.8
Headache pain in last month	0.6	1.0	2.2	-0.6	1.5	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.9	1.3	1.4	0.2
Glaucoma (self-reported)	0.8	1.0	1.6	1.2	-0.2	-1.3
Gout (self-reported)	0.4	0.5	1.2	0.5	1.1	-0.3
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	5.5	2.3	2.3	0.2
Medication: Amlodipine	0.5	0.8	2.1	-0.3	1.5	0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.1	-0.2	-0.3
Birth weight	0.0	0.0	0.1	0.1	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.6	-0.6	0.8	0.6
High blood pressure (siblings)	0.1	0.1	0.3	-0.6	0.3	0.0
Forced vital capacity (FVC), Best measure	0.6	2.1	5.0	2.2	-0.4	-1.1
Body fat percentage	1.1	4.5	8.6	1.9	-1.1	-2.9
Leg fat percentage (right)	1.2	4.4	8.8	1.6	-1.3	-3.0
Arm fat-free mass (right)	0.7	3.6	5.6	1.4	-1.8	-2.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.5	0.5	0.2
Comparative body size at age 10	0.1	0.2	0.3	0.4	0.1	-0.6
Number of full brothers	1.7	2.2	4.4	0.1	-2.1	-1.4
Worry too long after embarrassment	1.1	1.8	2.7	-1.4	-1.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	-1.5	0.6	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	1.5	-1.2	0.9	-0.9
Number of children fathered	1.2	1.4	2.3	1.1	-0.9	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.9	-1.4	1.0	0.6
Age at first live birth	0.3	0.6	1.1	-0.2	-1.1	-0.7
Pulse wave peak to peak time	0.5	0.6	0.9	0.6	-0.8	-0.9
Health satisfaction	1.1	1.4	3.3	0.9	1.8	-0.4
Shortness of breath walking on level ground	1.2	1.4	2.0	1.3	1.4	0.7
Qualifications: College or University degree	0.1	0.5	0.8	0.9	0.6	-0.5
Eye problems/disorders: None of the above	1.2	1.4	2.0	-0.8	1.4	1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.7	-0.1	-1.3
Emphysema/chronic bronchitis	2.1	2.4	3.4	-0.6	1.8	1.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	1.2	-0.3	-1.0
Neck or shoulder pain in last month	0.7	0.9	2.3	0.7	1.5	0.0
Medication: Blood pressure	0.1	0.2	0.4	-0.0	-0.6	0.3
Angina (self-reported)	0.3	0.3	1.0	-1.0	-0.0	0.0
Migraine (self-reported)	1.0	1.3	1.9	-1.4	-0.5	1.2
Medication: Ibuprofen	0.9	1.1	1.6	1.3	-0.4	-1.2
Medication: Allopurinol	0.4	0.6	1.6	-0.1	1.2	0.4
Medication: Omeprazole	1.0	1.2	2.4	-0.5	1.0	1.6
Medication: Seretide 50 evohaler	1.1	1.3	1.9	-0.9	1.0	1.4
Mean time to correctly identify matches	1.6	3.0	6.7	0.9	1.2	2.6
Heart disease (mother)	1.0	1.2	1.5	-1.2	-1.1	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.9	-0.1	-0.0
Whole body fat mass	1.4	5.7	9.7	2.2	-1.6	-3.1
Leg fat mass (right)	1.7	6.6	11.2	2.4	-1.7	-3.4
Arm predicted mass (right)	0.8	4.0	5.5	1.9	-1.8	-2.4
Pulse rate, automated reading	2.2	7.2	11.5	-1.7	-3.4	-2.7
Alcohol intake frequency.	0.3	0.7	2.1	1.4	-0.1	-0.2
Comparative height size at age 10	1.1	6.1	16.5	4.1	0.9	-1.0
Number of full sisters	0.1	0.1	0.2	-0.1	-0.4	0.2
Suffer from ‘nerves’	2.4	3.7	8.8	-3.0	-1.1	1.0
Overall health rating	0.1	0.2	0.6	-0.8	-0.3	-0.0
Chest pain or discomfort	0.3	0.4	0.5	0.6	-0.7	-0.5
Had major operations	0.2	0.2	0.5	-0.1	0.1	0.7
Age at last live birth	0.1	0.1	0.2	0.2	0.4	-0.4
Family relationship satisfaction	0.8	1.0	2.6	-0.5	1.6	-0.3
Leg pain on walking	2.2	2.7	6.5	2.5	1.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.3	-0.4	-1.5	0.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.0	-1.2	-1.4	0.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	5.6	2.4	1.0	0.3
Medication: Aspirin	0.7	0.9	1.7	-1.0	1.3	0.3
Supplements: Vitamin C	3.1	3.6	6.1	2.1	2.5	0.6
Knee pain experienced in last month	0.2	0.3	0.8	-0.3	0.0	0.9
Hypertension (Self-reported)	0.4	1.1	2.5	0.8	0.4	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-1.0	0.4	-0.0
Illnesses of father: Heart disease	0.9	1.2	2.2	-0.5	1.5	1.1
Illnesses of siblings: Diabetes	0.5	0.6	1.0	-0.8	-0.4	1.0
Smoking status: Previous	2.1	3.1	5.0	-2.2	-2.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.4	0.2	-1.0	-1.5
Whole body fat-free mass	0.7	4.3	6.8	2.2	-1.1	-2.6
Leg fat-free mass (right)	0.9	4.9	7.8	2.8	-0.4	-2.6
Arm fat percentage (left)	0.8	3.2	6.1	1.8	-0.4	-2.5
Average weekly red wine intake	0.8	1.2	2.3	-0.3	1.5	1.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.0	-1.1	0.9	2.0
Mood swings	0.3	0.5	0.9	-0.9	-0.0	0.9
Loneliness, isolation	0.3	0.5	1.0	0.1	1.0	-0.6
Long-standing illness, disability or infirmity	1.0	1.5	4.2	0.5	-0.4	-2.0
Ever had bowel cancer screening	2.6	3.0	6.1	-1.1	1.3	2.5
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.1	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.6	0.5	1.3	1.1
Friendships satisfaction	1.0	1.3	2.0	-1.4	1.3	0.2
Qualifications: nursing, teaching	0.5	0.8	2.1	1.4	0.3	-0.3
Commuting to job workplace: Walk	0.1	0.2	0.3	-0.5	0.4	0.2
Eye problems/disorders: Cataract	0.6	0.7	1.3	-0.8	-0.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	1.0	-0.4	-0.6
Medication for cholesterol	1.9	2.9	7.2	-0.2	-1.1	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.0	-0.4	-0.2
Back pain experienced in last month	0.8	1.2	2.8	-1.7	0.5	-0.8
Mineral and other dietary supplements	2.4	3.2	4.8	-0.5	-2.2	-2.1
Breast cancer (self-reported)	0.1	0.2	0.3	-0.1	-0.4	0.5
Asthma (self-reported)	0.2	0.5	1.2	-1.1	-0.4	-0.2
Osteoporosis (self-reported)	1.2	1.5	2.2	-1.5	-1.4	-0.5
Osteoarthritis (self-reported)	0.4	0.5	1.2	-0.1	-0.6	-1.1
Medication: Aspirin	0.6	0.7	1.2	-1.1	0.9	-0.3
Medication: Gliclazide	0.6	0.7	1.2	1.1	0.3	-0.9
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	-0.1	0.4	0.2
Smoking status: Current	0.6	0.9	2.3	-1.5	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	0.9	-0.3	-0.2
Whole body water mass	0.7	4.2	6.7	2.1	-1.2	-2.6
Leg predicted mass (right)	0.9	5.0	8.0	2.8	-0.4	-2.6
Arm fat mass (left)	1.0	4.2	7.4	2.0	-1.0	-2.7
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	-0.6	-0.4	0.7
Average weekly champagne plus white wine intake	1.1	1.5	2.4	1.4	0.3	-1.6
Miserableness	0.6	1.1	3.0	-1.7	0.4	-0.2
Guilty feelings	0.2	0.3	0.5	0.7	0.5	0.5
Wears glasses or contact lenses	2.0	2.3	5.7	2.4	0.4	-1.0
Ever taken oral contraceptive pill	1.5	1.7	3.9	0.5	2.0	-1.0
Hearing aid user	0.9	1.0	2.2	-1.5	-0.5	0.8
Mother’s age at death	0.2	0.2	0.4	0.7	0.4	0.2
Financial situation satisfaction	0.5	0.6	1.0	1.0	0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.8	0.4	-0.3	1.7
Commuting to job workplace: Public transport	0.4	0.5	0.7	0.6	-0.6	0.8
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.8	-0.4	-0.8
Medication: Blood pressure	2.6	4.9	10.0	-0.3	2.2	3.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.7	0.8	0.1	0.2
Supplements: Fish oil (including cod liver oil)	2.0	2.6	5.3	0.4	1.6	2.3
High cholesterol (Self-reported)	1.1	2.0	3.7	-1.5	0.2	1.9
Medication: Bendroflumethiazide	1.1	1.7	4.0	0.5	0.9	2.0
Medication: Paracetamol	0.2	0.3	0.6	0.8	-0.5	0.4
Medication: Lisinopril	0.2	0.3	0.4	-0.6	-0.6	-0.3
Medication: Atorvastatin	0.6	0.8	2.2	0.0	0.5	1.5
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.3	-0.1	-0.5
Alcohol drinker status: Never	0.5	0.6	1.8	1.4	-0.2	-0.1
Ever smoked	2.4	4.2	9.2	-3.0	-1.8	0.3
Basal metabolic rate	0.9	5.2	7.9	2.5	-1.1	-2.8
Leg fat percentage (left)	1.0	3.7	7.8	1.6	-0.9	-2.8
Arm fat-free mass (left)	0.9	4.6	6.9	1.9	-1.8	-2.6
Number of operations (self-reported)	0.1	0.2	0.4	0.3	-0.3	-0.6
Average weekly beer plus cider intake	0.7	1.1	2.4	-0.9	-1.6	-0.2
Irritability	0.3	0.5	0.7	-0.9	0.1	0.8
Risk taking	0.7	1.0	2.2	0.1	1.5	0.9
Ever had prostate specific antigen (PSA) test	1.9	2.1	5.4	-2.3	0.6	0.8
Fractured/broken bones in last 5 years	1.2	1.6	2.8	-1.7	-0.6	1.3
Age started oral contraceptive pill	0.5	0.7	1.1	-0.3	1.0	0.9
Diastolic blood pressure, automated reading	0.5	1.5	2.6	1.6	-0.2	-1.3
Ever depressed for a whole week	0.9	1.1	1.6	0.4	1.2	1.3
Unable to work because of sickness or disability	0.0	0.0	0.1	0.3	-0.0	-0.2
Commuting to job workplace: Cycle	0.7	0.9	2.4	-1.5	-0.3	0.5
Myopia	3.7	5.4	12.5	-0.8	-1.8	-3.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	0.0	-0.4	-1.6
Cholesterol lowering medication	1.3	2.0	3.5	0.4	1.5	1.9
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.5	-0.9	0.8	2.1
Pain experienced in last month	1.0	1.7	4.6	2.1	-0.5	0.5
Supplements: Calcium	0.3	0.3	0.7	-0.3	0.8	-0.2
Basal cell carcinoma (self-reported)	0.9	1.1	2.0	-1.4	-1.1	0.3
Heart attack/myocardial infarction (self-reported)	3.1	4.0	8.3	0.4	2.9	1.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.0	0.1	0.4
Heart disease (siblings)	1.0	1.2	3.6	0.2	-0.2	1.9
Alcohol drinker status: Previous	0.4	0.4	1.0	0.3	0.5	1.0
Pack years of smoking	0.3	0.4	0.9	0.9	0.3	-0.5
Impedance of whole body	0.0	0.2	0.3	-0.4	0.1	0.6
Leg fat mass (left)	1.5	5.9	9.7	2.5	-1.4	-3.1
Arm predicted mass (left)	0.7	3.8	5.4	1.8	-1.7	-2.3