Hub : Genes

C9orf152

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0479	0.0187	6.2e-05	0.019	0.021	0.024	NA	0.018	7.4e-05	3.2e-05	8.6e-06	NA	8.7e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0323	0.0164	6.6e-03	-0.002	0.003	-0.001	NA	-0.002	6.2e-01	1.3e-01	4.0e-01	NA	9.0e-01
3	TCGA	Brain Lower Grade Glioma	0.0394	0.0197	1.0e-03	0.026	0.033	0.023	NA	0.024	5.4e-04	9.6e-05	1.2e-03	NA	7.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.0	3.2	5.8	0.3	-1.9	-2.4
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	-1.1	0.3	-0.8
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	-0.9	-0.1	0.4
Depression (Nagel 2018)	1.1	1.6	2.6	1.1	1.0	1.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.4	0.6	1.2	-1.1
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.5	-0.9	-0.5
Schizophrenia (2018)	1.1	2.3	3.6	-1.6	1.9	0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-1.1	0.3	0.6
Worry (Nagel 2018)	1.2	2.5	4.9	-0.5	-2.2	-1.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	0.2	-0.5	1.4
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.7	-0.4	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	-0.2	0.3
Crohns Disease (2017)	0.1	0.3	0.4	-0.7	-0.5	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.1	-0.9	-0.2
Ulcerative Colitis (UC)	0.3	0.5	1.2	0.5	-1.1	-0.2
Major Depression (MDD)	0.3	0.4	0.8	0.9	-0.5	-0.2
Reaction Time	0.7	1.3	1.7	-1.2	-1.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.3	0.3	-0.1	-1.5
Breast Cancer	0.2	0.5	1.2	-0.0	-1.1	-0.6
Ovarian Cancer	0.3	0.4	1.1	0.0	-0.2	-1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.5	3.4	0.6	1.8	0.8
Bipolar Disorder (2011)	3.0	2.9	3.5	1.9	-1.3	-1.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.2	-0.8	0.2
Coronary Artery Disease (CAD)	1.7	2.0	5.0	-0.9	-2.2	0.5
Crohns Disease (2012)	0.0	0.0	0.1	-0.1	0.2	0.1
Mean Putamen Volume	1.5	1.7	4.4	0.3	0.8	2.1
Fasting Glucose	1.1	1.3	2.0	-1.4	1.4	0.1
HbA1C	0.5	0.6	0.7	0.8	-0.8	-0.6
HDL Cholesterol	0.4	0.7	1.7	1.3	0.4	0.3
LDL Cholesterol	0.4	0.7	1.9	0.1	-1.4	-0.3
Lupus	0.8	1.3	1.4	1.2	1.1	1.1
Neuroticism (2016)	0.2	0.3	0.7	-0.0	-0.8	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.3	0.9	-0.1
Rheumatoid Arthritis	0.5	0.6	1.8	0.2	-1.4	-0.2
Schizophrenia (2014)	0.2	0.5	1.4	-1.2	0.5	-0.1
Triglycerides	0.8	1.3	2.6	-1.6	-0.5	1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-0.4	-1.2	-0.7
Ulcerative Colitis	0.3	0.4	1.2	-0.0	-1.1	-0.1
Blood Eosinophil Count	0.2	1.2	1.5	0.7	1.2	1.2
Blood Platelet Count	0.0	0.0	0.1	0.3	0.1	-0.1
Blood Red Count	0.2	1.6	2.6	-0.8	-1.2	-1.6
Blood White Count	0.3	2.2	4.5	-2.1	1.2	0.8
Heel T-Score	0.1	1.0	1.4	1.0	0.8	-1.2
BMI	0.4	2.2	3.3	0.5	1.8	1.8
Height	1.1	21.6	36.4	-1.0	-6.0	-5.2
Waist Hip Ratio (WHR)	0.2	0.7	1.7	1.3	0.1	0.6
Systolic Blood Pressure	0.4	1.9	2.8	-1.2	-1.7	-1.2
Smoking Status	0.2	0.5	1.2	0.4	-1.1	0.4
Allergy or Eczema	0.5	1.3	1.9	-1.2	1.4	-0.6
Cardiovascular Disease	0.1	0.3	0.4	-0.5	0.6	-0.4
Hypothyroidism (self reported)	0.3	0.6	1.6	0.2	-1.3	-0.5
Respiratory disease	0.6	1.4	2.1	-1.4	0.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.9	-0.8	0.5	1.4
Lung FEV1/FVC ratio	0.3	1.3	3.3	0.4	0.7	1.8
Lung FVC	0.6	3.2	5.4	-0.1	-2.3	-2.0
Neuroticism	0.2	0.4	0.5	-0.7	-0.3	0.7
Chronotype (morning person)	1.3	3.1	3.6	1.6	1.7	1.9
Hair Pigment	0.0	1.0	2.6	-0.4	-1.6	-0.4
Tanning	0.1	1.2	2.1	-0.1	1.4	1.3
Hand grip strength (left)	0.1	0.2	0.4	-0.6	-0.5	-0.3
Number of treatments/medications taken	1.0	1.7	3.5	-1.3	1.9	0.1
Average weekly spirits intake	0.3	0.4	1.0	-1.0	0.3	0.0
Sensitivity / hurt feelings	0.1	0.1	0.2	0.2	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	2.3	3.2	4.9	0.4	2.1	2.2
Hearing difficulty/problems: Yes	0.6	1.0	1.6	1.1	0.5	-1.2
Relative age of first facial hair	0.5	1.1	2.6	-0.2	0.8	1.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	6.2	2.5	0.7	-0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.2	0.7	1.5	0.8
Ever had hysterectomy (womb removed)	0.9	1.1	2.9	0.5	0.1	-1.7
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.2	-0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.3	-0.1	1.0
Angina	0.5	0.6	0.9	0.7	0.9	-0.8
Medication for hormone replacement therapy	2.6	2.9	6.2	2.5	1.6	0.2
Vitamin and mineral supplements	1.2	1.6	4.0	-0.3	-2.0	-0.8
Supplements: Zinc	0.4	0.5	1.1	0.4	-1.0	-0.4
Medication: Co-codamol	0.4	0.5	0.9	0.0	-0.8	-0.9
Medication: Metformin	0.1	0.2	0.3	-0.1	-0.5	0.4
Diabetes (father)	0.6	0.7	1.0	-0.1	-1.0	-1.0
Diabetes (mother)	0.4	0.5	1.3	-0.2	-1.1	-0.3
Severe depression (siblings)	2.5	2.8	6.2	0.7	-1.3	-2.5
Pack years adult smoking proportion	2.1	3.3	4.8	-2.2	2.0	0.9
Impedance of leg (right)	0.5	2.4	3.1	1.8	-1.0	-1.8
Leg fat-free mass (left)	0.1	0.6	1.5	-1.2	-0.4	-0.1
Trunk fat percentage	0.1	0.6	1.1	-0.5	-0.7	-1.0
Hand grip strength (right)	0.3	0.7	1.4	-0.3	-1.2	-0.8
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.6	0.9	0.8
Current tobacco smoking	0.8	1.2	2.6	-0.1	1.6	1.0
Average weekly fortified wine intake	0.3	0.4	0.8	-0.9	-0.2	0.6
Maternal smoking around birth	0.9	1.3	1.8	1.0	1.0	1.4
Fed-up feelings	0.5	0.8	1.1	-0.9	0.8	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.4	0.2	1.6	0.7
Relative age voice broke	0.8	1.3	2.3	1.5	0.5	1.1
Taking other prescription medications	1.0	1.6	3.6	-1.9	0.8	-0.8
Age when periods started (menarche)	0.1	0.1	0.3	0.4	-0.1	0.5
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	3.9	1.8	2.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	6.1	-2.5	-1.0	-1.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.5	0.5	-0.0
Qualifications: CSEs or equivalent	0.4	0.6	0.7	-0.8	-0.6	0.8
Serious illness, injury or assault to yourself	3.6	4.4	8.0	0.8	2.1	2.8
High blood pressure	0.2	0.6	1.2	-1.1	-0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.1	-1.8	1.0	-0.5
Multivitamins +/- minerals	1.2	1.5	3.4	0.5	1.8	0.9
Stomach or abdominal pain in last month	0.5	0.6	1.0	-0.8	1.0	-0.2
Supplements: Glucosamine	0.7	0.9	1.4	0.3	-1.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	0.2	-0.3	-1.3
Medication: Atenolol	0.1	0.1	0.2	0.2	-0.0	0.4
Medication: Levothyroxine sodium	0.3	0.5	0.6	0.6	-0.7	-0.7
Sitting height	0.5	3.8	6.5	-1.1	-2.5	-1.9
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-0.3	1.1	0.5
High blood pressure (mother)	2.3	3.3	4.3	-1.8	-1.6	-2.1
Body mass index (BMI)	0.3	1.1	1.8	-1.3	1.1	0.6
Impedance of leg (left)	0.4	1.7	2.1	1.2	-1.3	-1.4
Leg predicted mass (left)	0.1	0.5	1.3	-1.1	-0.4	-0.1
Trunk fat mass	0.2	0.8	1.1	-0.7	-0.9	-1.1
Waist circumference	0.0	0.0	0.1	-0.2	0.3	-0.0
Number of incorrect matches in round	0.2	0.4	0.8	0.4	0.9	0.5
Past tobacco smoking	1.7	3.1	7.2	-0.5	2.7	1.4
Alcohol usually taken with meals	0.3	0.5	0.7	0.8	0.6	0.6
Nervous feelings	1.2	2.3	5.1	-0.7	-1.1	-2.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.0	-0.3	-1.0
Hearing difficulty/problems with background noise	2.5	4.0	7.9	-0.1	-2.0	-2.8
Hair/balding pattern: Pattern 2	1.3	1.6	3.2	1.8	0.9	0.9
Had menopause	3.0	3.7	9.9	-0.1	3.1	1.1
Had other major operations	0.6	0.7	1.7	0.5	1.3	-0.3
Forced vital capacity (FVC)	2.9	11.0	24.0	-0.5	-4.9	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.3	-1.4	-1.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.2	0.7	1.1	0.9
Qualifications: None of the above	1.0	2.1	3.2	-0.3	1.7	1.8
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.6	0.4	0.5
Mouth/teeth dental problems	0.7	1.1	3.0	-1.7	-0.6	-0.3
Heart attack	0.3	0.3	0.6	0.2	0.6	0.8
Allergy	1.0	2.2	4.5	2.1	-0.7	1.3
Pain all over the body in last month	0.4	0.4	0.6	0.8	0.6	0.4
Diabetes (self-reported)	1.0	1.5	3.4	-0.6	0.8	1.8
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	5.5	-0.8	-1.3	-2.3
Medication: Ramipril	1.1	1.4	3.0	-1.1	-0.2	-1.7
Medication: Simvastatin	1.8	2.6	5.3	-0.5	2.3	1.5
Fluid intelligence score	0.5	1.1	3.1	0.1	-0.3	-1.8
Illnesses of siblings	0.1	0.1	0.3	-0.1	-0.5	0.3
Neuroticism score	0.4	0.9	1.9	-1.4	-0.7	-0.4
Weight	0.2	0.9	1.3	-1.1	-0.8	-0.8
Impedance of arm (right)	0.7	3.4	4.2	1.6	-1.8	-2.0
Arm fat percentage (right)	0.2	0.7	1.3	-1.2	-0.1	-0.8
Trunk fat-free mass	0.2	1.3	2.4	-1.5	-1.0	-0.8
Hip circumference	0.1	0.3	0.9	-0.9	0.1	-0.0
Time employed in main current job	1.3	1.5	4.3	2.1	0.4	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.2	-0.4	-0.1
Father’s age at death	0.4	0.5	1.3	-0.2	-0.5	-1.2
Worrier / anxious feelings	0.8	1.5	2.7	-1.0	-1.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.3	-0.1	-0.4
Falls in the last year	0.0	0.0	0.1	-0.2	0.3	0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.2	0.3	-0.4
Number of live births	0.1	0.2	0.4	-0.6	0.4	0.2
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	15.3	-0.5	-3.9	-1.8
Pulse rate	0.1	0.1	0.2	-0.5	0.2	0.1
Happiness	0.6	0.8	1.4	-0.1	-1.0	-1.2
Noisy workplace	0.9	1.2	2.9	-1.7	-0.7	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.7	-0.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.3	0.6	0.3
Mouth/teeth dental problems: Dentures	0.7	1.3	3.2	0.1	0.8	1.8
Asthma	1.5	3.0	7.4	-2.7	0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	4.4	1.9	2.1	1.3
Medication: Cholesterol lowering	2.2	3.4	5.1	0.4	2.3	2.2
Depression (self-reported)	0.6	0.8	2.1	-1.4	-0.3	-0.4
Medication: Lansoprazole	0.7	0.8	1.2	0.5	0.9	1.1
Prospective memory result	1.6	2.0	3.3	-0.4	1.8	1.5
Lung cancer (father)	1.4	1.6	2.9	0.7	1.7	1.2
Illnesses of mother	0.2	0.3	0.8	-0.2	0.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	11.2	-0.1	-3.3	-1.6
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	0.2	-0.5	0.5
Impedance of arm (left)	0.7	3.3	4.0	1.9	-2.0	-1.6
Arm fat mass (right)	0.1	0.6	1.1	-1.1	-0.1	-0.8
Trunk predicted mass	0.2	1.4	2.3	-1.5	-1.1	-0.8
Standing height	1.0	10.3	16.9	0.6	-4.1	-3.7
Length of working week for main job	2.5	2.7	4.5	-0.5	2.1	1.9
Exposure to tobacco smoke at home	0.6	0.7	1.1	-1.0	-0.6	-0.8
Breastfed as a baby	0.5	0.6	1.2	-0.1	-0.8	-1.1
Tense / ‘highly strung’	1.6	2.6	4.1	-1.1	-1.6	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.2	1.1	0.8	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	0.4	0.4	0.4
Birth weight of first child	3.1	5.7	6.3	-2.4	-2.5	-2.2
Peak expiratory flow (PEF)	0.4	0.8	1.3	1.1	-1.1	0.1
Pulse wave reflection index	0.1	0.2	0.2	-0.5	-0.4	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.0	-0.6	-0.9
Loud music exposure frequency	0.3	0.4	1.1	1.0	0.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.6	0.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.3	-0.1	-0.8
Blood clot in the leg (DVT)	0.8	1.0	2.6	-0.5	-0.4	-1.6
Medication: Paracetamol	0.3	0.6	0.8	-0.9	0.7	0.6
Headache pain in last month	0.8	1.3	3.0	0.4	0.9	1.7
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.2	-0.6	-2.5	-1.4
Glaucoma (self-reported)	0.6	0.7	2.0	1.4	0.0	0.5
Gout (self-reported)	1.0	1.4	4.0	2.0	0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.6	0.3	-1.2	-1.2
Medication: Amlodipine	0.9	1.2	3.2	1.8	-0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.0	-0.9	-0.6	-1.4
Birth weight	0.2	0.4	1.1	-0.0	-1.1	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.0	1.7	-0.4	-0.4
High blood pressure (siblings)	0.1	0.1	0.1	-0.4	-0.3	0.3
Forced vital capacity (FVC), Best measure	2.3	8.3	17.4	-0.2	-4.2	-2.7
Body fat percentage	0.1	0.2	0.4	-0.6	-0.3	-0.5
Leg fat percentage (right)	0.1	0.2	0.4	-0.5	0.6	0.1
Arm fat-free mass (right)	0.1	0.6	1.6	-1.3	-0.4	-0.4
Exposure to tobacco smoke outside home	0.7	1.0	1.8	-1.3	-1.0	-0.2
Comparative body size at age 10	0.2	0.6	1.3	1.1	-0.4	0.5
Number of full brothers	1.1	1.4	4.0	-0.1	2.0	0.5
Worry too long after embarrassment	1.6	2.7	4.5	-1.0	-1.6	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.4	-0.3
Wheeze or whistling in the chest in last year	1.5	2.6	7.1	-0.8	2.7	0.1
Number of children fathered	0.2	0.3	0.5	-0.7	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	3.5	1.6	-1.1	-1.9
Age at first live birth	1.4	2.5	3.8	1.5	-1.9	-1.3
Pulse wave peak to peak time	0.3	0.3	1.0	-0.2	0.1	-1.0
Health satisfaction	0.2	0.2	0.3	0.6	0.6	0.1
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.4	0.6	0.5
Qualifications: College or University degree	0.3	0.8	2.0	1.4	-0.4	-0.5
Eye problems/disorders: None of the above	3.4	4.0	5.1	-2.3	-2.0	-1.7
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.2	0.7	0.8	1.1
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.1	-0.6	-0.9
Medication for pain relief, constipation, heartburn	2.0	3.4	6.6	-0.9	-2.6	-1.7
Neck or shoulder pain in last month	0.3	0.5	0.9	0.8	0.9	0.0
Medication: Blood pressure	0.9	1.5	4.1	0.7	2.0	-0.1
Angina (self-reported)	0.4	0.5	1.0	0.2	1.0	-0.8
Migraine (self-reported)	0.5	0.7	1.4	0.2	1.2	0.7
Medication: Ibuprofen	2.2	2.6	4.0	1.9	2.0	0.4
Medication: Allopurinol	0.9	1.2	2.0	1.1	-1.4	-0.6
Medication: Omeprazole	1.0	1.2	3.2	0.0	1.8	0.6
Medication: Seretide 50 evohaler	1.0	1.1	1.6	-1.0	0.8	1.3
Mean time to correctly identify matches	0.3	0.5	0.9	-0.7	-0.4	-1.0
Heart disease (mother)	0.3	0.4	1.0	0.1	1.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.5	-1.2	-1.0	-1.1
Whole body fat mass	0.1	0.4	0.4	-0.6	-0.6	-0.6
Leg fat mass (right)	0.0	0.1	0.2	-0.5	0.4	0.2
Arm predicted mass (right)	0.2	0.9	2.0	-1.4	-0.6	-0.5
Pulse rate, automated reading	0.1	0.3	0.7	-0.9	-0.2	0.5
Alcohol intake frequency.	1.1	2.4	4.8	0.8	1.4	2.2
Comparative height size at age 10	1.5	8.5	13.6	0.4	-3.7	-3.4
Number of full sisters	0.2	0.2	0.3	0.6	0.4	-0.3
Suffer from ‘nerves’	2.4	3.7	6.4	-1.0	-2.5	-1.9
Overall health rating	0.8	1.6	3.7	-0.1	1.9	1.1
Chest pain or discomfort	4.4	6.3	9.5	0.3	3.1	3.0
Had major operations	1.2	1.4	1.9	1.0	1.2	1.4
Age at last live birth	1.0	1.5	2.1	1.2	-1.5	-1.0
Family relationship satisfaction	0.4	0.5	0.9	0.1	-1.0	-0.7
Leg pain on walking	1.1	1.3	2.4	-1.2	1.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	-0.1	1.4	1.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.2	2.3	1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	2.7	1.1	-1.1	-1.7
Medication: Aspirin	1.2	1.6	2.9	1.0	1.7	0.9
Supplements: Vitamin C	0.8	0.9	2.5	0.2	1.6	0.5
Knee pain experienced in last month	0.8	1.2	2.0	-0.7	1.1	1.4
Hypertension (Self-reported)	0.3	0.8	2.0	-1.4	0.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.4
Illnesses of father: Heart disease	1.5	2.1	3.4	-0.6	-1.8	-1.6
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.0	0.4	-0.6
Smoking status: Previous	1.9	2.9	6.2	0.9	-2.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.1	10.5	-0.4	-3.2	-2.1
Whole body fat-free mass	0.2	1.2	2.6	-1.6	-0.8	-0.6
Leg fat-free mass (right)	0.2	0.8	1.9	-1.4	-0.7	-0.1
Arm fat percentage (left)	0.1	0.5	1.2	-1.1	-0.2	-0.5
Average weekly red wine intake	1.2	1.8	2.7	0.2	-1.6	-1.6
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.4	0.2	1.5	1.4
Mood swings	0.3	0.5	0.8	-0.4	0.9	0.7
Loneliness, isolation	0.4	0.6	1.3	-1.1	0.3	0.5
Long-standing illness, disability or infirmity	0.3	0.5	0.9	0.7	0.9	-0.2
Ever had bowel cancer screening	0.2	0.2	0.5	0.1	0.2	-0.7
Diabetes diagnosed by doctor	0.6	0.9	1.7	-0.8	0.6	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.3	-0.6	0.2
Friendships satisfaction	1.0	1.3	2.7	-0.5	-1.6	-1.0
Qualifications: nursing, teaching	0.4	0.6	1.1	0.8	-1.1	-0.2
Commuting to job workplace: Walk	0.7	0.8	1.0	-1.0	-0.9	-0.8
Eye problems/disorders: Cataract	4.1	4.7	6.8	2.6	2.5	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	-0.2	-0.4
Medication for cholesterol	0.4	0.7	1.3	0.1	0.9	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.2	2.1	0.4	-0.4
Back pain experienced in last month	1.0	1.5	2.4	-0.0	1.4	-1.5
Mineral and other dietary supplements	0.2	0.3	0.5	-0.5	-0.7	0.5
Breast cancer (self-reported)	0.9	1.1	1.7	0.8	1.0	1.3
Asthma (self-reported)	1.6	3.2	8.1	-2.8	0.1	-1.2
Osteoporosis (self-reported)	0.5	0.7	0.9	0.4	0.9	1.0
Osteoarthritis (self-reported)	0.4	0.6	0.8	0.4	0.9	0.9
Medication: Aspirin	1.5	2.0	3.5	1.1	1.9	1.1
Medication: Gliclazide	0.0	0.0	0.0	0.1	0.1	0.1
Illnesses of father: None of the above (group 1)	1.4	1.7	4.3	0.1	0.8	2.1
Smoking status: Current	0.4	0.7	1.4	0.2	1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	1.5	0.2	0.3
Whole body water mass	0.2	1.2	2.6	-1.6	-0.8	-0.5
Leg predicted mass (right)	0.2	0.8	1.9	-1.4	-0.8	-0.2
Arm fat mass (left)	0.2	0.6	1.0	-1.0	-0.5	-0.8
Number of self-reported non-cancer illnesses	0.8	1.3	3.2	-0.4	1.8	-0.8
Average weekly champagne plus white wine intake	0.2	0.2	0.3	0.4	-0.5	-0.5
Miserableness	0.3	0.5	1.2	-1.1	-0.0	0.4
Guilty feelings	0.5	0.8	1.8	0.3	1.3	0.7
Wears glasses or contact lenses	2.0	2.3	4.0	-0.9	2.0	1.5
Ever taken oral contraceptive pill	2.3	2.5	4.1	2.0	1.2	1.4
Hearing aid user	1.5	1.6	4.1	-2.0	0.5	-0.7
Mother’s age at death	0.3	0.3	0.8	0.3	0.4	0.9
Financial situation satisfaction	1.3	1.6	2.5	-1.6	0.9	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.7	-0.4	0.1	1.6
Commuting to job workplace: Public transport	1.6	1.9	5.1	-2.3	-0.7	-0.2
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	1.3	0.2	1.3
Medication: Blood pressure	0.5	0.9	1.2	-1.0	-1.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.2	-0.0	0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.3	0.6	-0.6
High cholesterol (Self-reported)	1.6	2.8	4.8	0.8	2.2	1.7
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	0.3	-0.7
Medication: Paracetamol	0.4	0.6	0.9	-0.5	0.8	1.0
Medication: Lisinopril	0.2	0.3	0.7	-0.4	0.0	0.9
Medication: Atorvastatin	1.8	2.2	3.3	0.9	-1.8	-1.6
Illnesses of father: High blood pressure	1.2	1.5	2.9	-0.9	-0.9	-1.7
Alcohol drinker status: Never	0.1	0.2	0.4	0.2	-0.6	0.3
Ever smoked	1.6	2.9	6.0	-0.2	-2.4	-1.6
Basal metabolic rate	0.2	1.0	2.0	-1.4	-0.8	-0.6
Leg fat percentage (left)	0.1	0.3	0.6	-0.8	0.5	0.3
Arm fat-free mass (left)	0.2	1.0	1.9	-1.4	-0.5	-0.8
Number of operations (self-reported)	1.1	1.6	3.2	1.8	1.0	0.8
Average weekly beer plus cider intake	0.9	1.3	2.1	-1.5	0.7	1.1
Irritability	0.1	0.1	0.2	0.2	0.4	0.4
Risk taking	1.1	1.6	4.0	0.2	2.0	0.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.2	1.8	0.4	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	2.1	-1.5	0.3	-0.3
Age started oral contraceptive pill	1.6	2.0	4.7	-1.1	-0.4	-2.2
Diastolic blood pressure, automated reading	0.7	2.1	3.5	-1.4	-1.9	-1.0
Ever depressed for a whole week	0.2	0.3	0.4	0.5	0.7	0.4
Unable to work because of sickness or disability	0.6	0.7	1.1	1.1	1.0	0.4
Commuting to job workplace: Cycle	1.4	1.7	2.6	0.2	-1.6	-1.5
Myopia	0.3	0.4	0.7	0.1	-0.8	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	1.1	-0.6	0.2
Cholesterol lowering medication	0.5	0.7	2.0	-1.4	0.4	0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.3	-0.2	1.5	0.2
Pain experienced in last month	1.3	2.2	3.3	1.8	-1.7	-0.5
Supplements: Calcium	1.1	1.2	2.6	-1.6	-0.2	-1.1
Basal cell carcinoma (self-reported)	1.0	1.2	3.0	0.6	-1.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.2	0.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.9	-0.6	-0.5	-1.7
Heart disease (siblings)	0.3	0.3	0.6	0.7	0.0	-0.7
Alcohol drinker status: Previous	0.4	0.5	0.8	0.9	0.9	0.0
Pack years of smoking	2.1	3.1	4.7	-2.2	2.0	0.8
Impedance of whole body	0.6	3.3	3.5	1.9	-1.8	-1.7
Leg fat mass (left)	0.1	0.3	0.5	-0.7	0.5	0.4
Arm predicted mass (left)	0.2	0.8	1.8	-1.4	-0.3	-0.6