TWAS hub - C9orf40

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.246	0.091	6.6e-03	0.033	NA	0.075	NA	0.062	3.8e-02	NA	3.1e-03	NA	6.6e-03
2	GTEx	Colon Transverse	0.182	0.049	3.8e-05	0.127	NA	0.113	NA	0.093	1.2e-06	NA	4.9e-06	NA	3.5e-05
3	GTEx	Skin Sun Exposed Lower leg	0.075	0.033	4.8e-03	-0.003	NA	0.005	NA	-0.002	7.6e-01	NA	1.2e-01	NA	6.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Illnesses of siblings: Diabetes	5.1	6.3	8.7	-3.0	-1.8	-2.6
Diabetes (father)	4.6	5.7	10.2	-2.1	-1.5	-3.2
Impedance of arm (right)	4.1	19.0	37.1	3.8	2.4	6.1
Number of incorrect matches in round	4.0	6.6	10.6	3.3	2.9	1.1
Blood clot in the leg (DVT)	4.0	5.2	8.8	-0.9	-3.0	-2.5
Guilty feelings	4.0	6.0	10.3	-1.1	-2.5	-3.2
Chronic bronchitis/emphysema (mother)	3.9	4.5	7.0	2.1	2.7	1.4
Medication: Simvastatin	3.5	5.2	11.0	-2.0	-3.3	-0.7
Impedance of arm (left)	3.4	15.9	33.9	3.3	1.7	5.8
Medication: Allopurinol	3.1	4.2	9.4	-1.5	-3.1	-1.0
Back pain experienced in last month	3.0	4.4	7.6	2.3	2.7	0.7
Number of operations (self-reported)	3.0	4.5	7.9	-0.1	-2.8	-2.4
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	6.4	-0.4	-2.5	-2.3
Medication: Ramipril	2.9	3.8	9.5	-1.2	-0.7	-3.1
Arm fat-free mass (left)	2.9	14.6	21.8	-4.7	-2.3	-4.1
BMI	2.8	16.3	22.3	-4.7	-3.9	-3.4
Arm fat-free mass (right)	2.7	13.6	19.6	-4.4	-2.3	-4.0
Arm predicted mass (left)	2.7	13.9	20.9	-4.6	-2.5	-3.8
Arm predicted mass (right)	2.5	12.8	17.7	-4.2	-2.4	-3.9
Illnesses of father: None of the above (group 1)	2.5	3.0	4.4	1.9	1.0	2.1
Impedance of whole body	2.5	12.9	27.3	3.1	1.4	5.2
Trunk predicted mass	2.3	12.9	17.6	-4.2	-1.9	-4.2
Birth weight	2.3	4.9	11.2	-1.2	-3.3	-1.5
Leg pain on walking	2.3	2.9	5.0	-1.7	-2.2	-0.8
Wears glasses or contact lenses	2.3	2.6	6.2	2.5	1.1	0.7
Triglycerides	2.2	3.5	4.7	-2.2	-1.3	-2.0
Trunk fat-free mass	2.2	12.8	17.6	-4.2	-1.9	-4.2
Age at last live birth	2.2	3.2	4.9	1.0	2.2	1.9
Hand grip strength (right)	2.1	5.6	11.3	-3.4	-1.7	-1.7
Current tobacco smoking	2.1	3.4	6.1	2.0	2.5	0.4
Whole body fat-free mass	2.1	12.1	19.0	-4.4	-2.1	-3.6
Whole body water mass	2.1	11.8	18.5	-4.3	-2.0	-3.6
Basal metabolic rate	2.1	11.5	19.6	-4.4	-2.3	-3.1
Qualifications: None of the above	2.0	4.4	8.1	2.8	0.5	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	7.2	2.7	0.0	0.8
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.8	-0.9	-1.9	-1.5
Supplements: Fish oil (including cod liver oil)	2.0	2.7	5.5	-1.1	-1.2	-2.3
Alcohol drinker status: Never	2.0	2.4	4.5	2.1	1.6	0.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	4.0	-2.0	-0.5	-1.8
High blood pressure (mother)	1.9	2.7	3.2	-1.8	-1.7	-1.4
Medication: Paracetamol	1.9	3.2	8.3	1.1	-0.1	-2.9
Medication: Paracetamol	1.9	3.0	8.4	0.8	-0.1	-2.9
Chronotype (morning person)	1.8	4.2	6.5	1.5	2.5	2.0
Leg fat mass (right)	1.8	6.9	13.2	-3.6	-2.6	-0.9
Supplements: Vitamin C	1.8	2.2	3.3	1.8	1.8	0.2
Irritability	1.8	3.0	5.3	-0.8	-2.3	-1.8
Alzheimer’s Disease (in father)	1.7	1.8	2.2	1.5	1.2	1.4
Leg fat-free mass (left)	1.7	9.0	16.3	-4.0	-2.3	-2.3
Leg predicted mass (left)	1.7	9.1	16.7	-4.1	-2.3	-2.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	3.7	1.6	0.2	-1.9
Smoking status: Current	1.7	2.7	4.2	2.1	1.9	0.4
Leg fat mass (left)	1.7	6.5	11.9	-3.5	-2.5	-1.0
Illnesses of siblings	1.6	2.2	2.4	1.6	1.5	1.4
Weight	1.6	7.7	14.6	-3.8	-2.3	-1.8
Risk taking	1.6	2.3	4.6	1.4	0.6	2.1
Crohns Disease (2017)	1.5	3.2	6.5	2.5	1.7	0.7
Serious illness, injury or assault to yourself	1.5	1.8	4.5	2.1	1.0	0.0
Body mass index (BMI)	1.5	6.5	10.9	-3.3	-2.1	-2.1
Waist circumference	1.5	5.3	7.7	-2.8	-2.1	-1.9
Happiness	1.5	1.8	4.9	-2.2	-0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.7	0.2	-1.9	-1.8
Arm fat mass (left)	1.5	6.2	12.7	-3.6	-2.3	-0.8
Ever smoked	1.5	2.7	5.5	1.5	2.4	0.7
Worry (Nagel 2018)	1.4	3.0	8.8	0.2	0.4	-3.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.4	-0.2	-0.0	-2.1
Worrier / anxious feelings	1.4	2.6	7.4	-0.4	0.3	-2.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.0	0.2	-1.6	-1.7
Medication: Amlodipine	1.4	2.0	4.2	0.2	2.0	1.4
Exposure to tobacco smoke outside home	1.4	1.8	5.0	-0.0	-2.2	-0.7
Wheeze or whistling in the chest in last year	1.4	2.5	5.1	2.3	0.8	1.4
Family relationship satisfaction	1.4	1.8	3.4	-1.8	-1.4	-0.2
Knee pain experienced in last month	1.4	2.1	3.7	-0.8	-1.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.2	0.9	1.5	1.4
Leg fat-free mass (right)	1.4	7.5	13.2	-3.6	-2.0	-2.3
Leg predicted mass (right)	1.4	7.5	13.2	-3.6	-1.9	-2.3
Schizophrenia vs Biploar Disorder	1.3	1.7	3.9	2.0	0.2	1.1
Age at First Birth	1.3	1.9	4.0	-0.8	1.0	2.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.1	-0.7	-2.0	0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	2.5	1.5	1.6	0.7
Worry too long after embarrassment	1.3	2.2	6.5	0.2	0.2	-2.5
Medication for pain relief, constipation, heartburn	1.3	2.3	3.9	-1.7	0.3	2.0
Medication: Omeprazole	1.3	1.5	4.2	0.0	-2.0	0.7
Whole body fat mass	1.3	5.4	11.4	-3.4	-2.2	-0.1
Suffer from ‘nerves’	1.3	2.1	3.4	1.9	1.6	0.6
Medication: Bendroflumethiazide	1.3	1.9	3.0	-1.6	-1.7	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.8	0.2	-1.9	0.9
Neuroticism (Nagel 2018)	1.2	2.8	7.1	-0.1	-1.1	-2.7
Prostate Cancer	1.2	1.6	4.5	0.2	2.1	0.6
Supplements: Zinc	1.2	1.3	2.3	-1.5	0.7	-1.0
Severe depression (siblings)	1.2	1.3	2.3	1.1	-1.5	-0.5
Impedance of leg (left)	1.2	5.6	9.1	2.5	1.3	3.0
Arm fat mass (right)	1.2	5.0	10.3	-3.2	-2.1	-0.6
Gout (self-reported)	1.2	1.6	3.9	-0.9	-2.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.8	1.1	1.0	1.4
Friendships satisfaction	1.2	1.5	3.0	-1.2	-1.7	-0.4
Mineral and other dietary supplements	1.2	1.7	3.6	1.1	0.4	1.9
Breast cancer (self-reported)	1.2	1.5	4.4	0.2	2.1	0.1
Medication: Atorvastatin	1.2	1.5	2.9	1.7	0.9	-0.9
Myopia	1.2	1.8	2.6	-1.6	-0.9	-1.4
Neuroticism	1.1	2.7	6.2	-1.1	-0.8	-2.5
Ever had hysterectomy (womb removed)	1.1	1.2	1.9	-1.2	-1.4	0.5
Neuroticism score	1.1	2.2	5.7	-0.2	-1.0	-2.4
Hip circumference	1.1	4.8	10.5	-3.2	-1.7	-0.9
Depression (self-reported)	1.1	1.3	3.5	0.3	-1.9	-0.7
Heart disease (mother)	1.1	1.3	3.3	1.8	0.7	0.5
Comparative height size at age 10	1.1	6.1	8.9	-2.2	-2.1	-3.0
Ever taken oral contraceptive pill	1.1	1.2	3.3	0.0	-0.5	-1.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	0.3	1.5	1.3
Reaction Time	1.0	1.9	5.2	-0.1	-2.3	-0.7
Neuroticism (2016)	1.0	1.4	2.8	-0.7	-1.0	-1.7
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.2	-0.4	-1.8	-0.2
Smoking Status	1.0	2.4	3.0	1.6	1.7	1.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.2	-1.6	-0.3	-1.8
Chronic bronchitis/emphysema (father)	1.0	1.2	1.7	-1.1	-1.3	0.7
Allergy	1.0	2.3	3.1	-1.3	1.8	1.4
Pulse wave reflection index	1.0	1.2	2.0	0.9	1.4	0.9
Loud music exposure frequency	1.0	1.0	2.0	-1.1	0.0	1.4
Leg fat percentage (right)	1.0	3.8	8.5	-2.9	-1.7	0.1
Medication: Ibuprofen	1.0	1.2	2.2	1.5	0.7	-1.0
Mean time to correctly identify matches	1.0	1.9	5.5	-0.2	-2.4	-0.0
Overall health rating	1.0	2.2	3.3	-0.7	-1.8	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	0.9	1.5	0.6
Average weekly champagne plus white wine intake	1.0	1.3	2.1	-1.5	-1.1	-0.8
Bipolar Disorder (2018)	0.9	1.4	3.4	-0.6	0.6	-1.8
Bipolar Disorder or Schizophrenia	0.9	2.3	6.0	-0.2	-0.8	-2.5
Irritable Bowel Disease (IBD)	0.9	2.3	3.4	1.8	1.7	0.6
Fasting Glucose	0.9	1.1	2.7	-0.7	-0.3	1.6
Hand grip strength (left)	0.9	2.3	6.1	-2.5	-0.7	-0.6
Impedance of leg (right)	0.9	4.2	7.9	1.9	1.0	2.8
Relative age voice broke	0.9	1.3	1.7	-1.3	-0.8	1.3
Trunk fat mass	0.9	4.0	8.0	-2.8	-1.9	0.6
Diabetes (self-reported)	0.9	1.4	2.1	-1.5	0.3	-1.4
Body fat percentage	0.9	3.6	6.1	-2.5	-1.7	1.3
Number of children fathered	0.9	1.0	2.9	1.7	0.5	0.1
Qualifications: College or University degree	0.9	2.7	4.5	-2.1	0.9	1.7
Medication: Seretide 50 evohaler	0.9	1.1	2.7	0.2	-1.6	0.7
Arm fat percentage (left)	0.9	3.5	6.2	-2.5	-1.9	0.7
Leg fat percentage (left)	0.9	3.1	6.9	-2.6	-1.5	0.1
Commuting to job workplace: Cycle	0.9	1.1	1.6	-0.4	1.3	1.2
Schizophrenia (2018)	0.8	1.7	2.8	0.2	-1.6	-1.7
Major Depression (MDD)	0.8	1.0	3.0	-0.3	-0.1	-1.7
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	-0.8	0.1	1.6
Coronary Artery Disease (CAD)	0.8	1.0	2.6	-0.2	0.6	-1.6
Mean Putamen Volume	0.8	0.9	2.6	1.6	0.2	-0.3
Allergy or Eczema	0.8	2.1	4.2	1.0	-2.0	-1.2
Hypothyroidism (self reported)	0.8	1.9	5.3	0.5	-2.3	-0.5
Sensitivity / hurt feelings	0.8	1.3	2.3	-0.9	-1.0	-1.5
Medication: Metformin	0.8	1.2	2.2	-1.1	-0.3	-1.5
Trunk fat percentage	0.8	3.3	4.3	-2.1	-1.6	1.7
Fed-up feelings	0.8	1.4	1.6	-1.3	-1.2	-1.1
Nervous feelings	0.8	1.5	4.4	-0.3	-0.3	-2.1
Had menopause	0.8	1.0	2.1	0.8	-0.6	-1.4
Prospective memory result	0.8	1.0	2.7	0.4	-0.3	-1.6
Age at first live birth	0.8	1.4	2.7	-0.3	1.7	1.2
Qualifications: nursing, teaching	0.8	1.3	2.6	-1.6	-0.6	-0.9
Osteoporosis (self-reported)	0.8	1.0	2.2	0.4	1.5	-0.8
Miserableness	0.8	1.4	4.1	-0.0	-2.0	-0.2
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.1	0.9	1.4
HbA1C	0.7	0.8	0.9	0.8	-0.9	1.0
Blood White Count	0.7	5.2	7.0	2.3	1.8	2.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.1	-0.3	-1.5	-0.8
Systolic blood pressure, automated reading	0.7	2.0	2.2	1.2	-1.5	1.5
Diabetes (mother)	0.7	0.9	2.0	0.2	1.4	-0.7
Qualifications: CSEs or equivalent	0.7	1.0	2.1	-0.9	-0.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	-1.3	-0.2	-1.3
Arm fat percentage (right)	0.7	2.9	5.8	-2.4	-1.6	0.6
Asthma	0.7	1.3	2.2	1.5	-1.3	0.5
High blood pressure (siblings)	0.7	1.0	1.2	-0.9	-1.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	0.9	1.0	-0.9	-0.8
Number of full sisters	0.7	0.8	1.3	1.0	-0.5	1.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.6	-1.3	-1.0	-0.5
Average weekly red wine intake	0.7	1.0	1.7	0.7	-0.8	1.3
Mood swings	0.7	1.2	2.1	0.6	-1.1	-1.4
Diabetes diagnosed by doctor	0.7	1.1	1.8	-1.3	0.2	-1.2
Hearing aid user	0.7	0.8	1.9	0.7	-0.1	-1.4
Crohns Disease (2012)	0.6	1.0	2.6	1.6	0.5	0.2
Respiratory disease	0.6	1.3	2.8	1.7	-1.0	-0.4
Townsend deprivation index at recruitment	0.6	0.8	1.3	-1.1	0.2	-1.0
Age when periods started (menarche)	0.6	1.4	3.0	-0.2	1.1	1.7
Multivitamins +/- minerals	0.6	0.7	1.6	-0.4	-0.7	-1.3
Stomach or abdominal pain in last month	0.6	0.8	1.6	0.3	-0.8	-1.3
Financial difficulties in last 2 years	0.6	0.8	1.8	0.6	1.4	0.4
Mouth/teeth dental problems	0.6	0.9	1.4	-1.2	0.1	1.1
Falls in the last year	0.6	0.8	1.0	0.8	0.8	-1.0
Number of live births	0.6	0.9	1.5	0.7	-0.9	-1.2
Breastfed as a baby	0.6	0.8	1.2	1.1	-0.4	1.0
Tense / ‘highly strung’	0.6	1.0	2.9	0.3	-0.4	-1.7
Glaucoma (self-reported)	0.6	0.7	1.9	0.6	-1.4	-0.2
Comparative body size at age 10	0.6	1.6	3.1	-0.0	1.3	1.8
Eye problems/disorders: None of the above	0.6	0.6	1.7	-0.4	-0.0	-1.3
Medication: Aspirin	0.6	0.8	1.6	-0.6	-0.7	-1.3
Ever had bowel cancer screening	0.6	0.7	2.1	1.4	0.3	0.2
Asthma (self-reported)	0.6	1.2	2.4	1.5	-0.9	0.6
Ever depressed for a whole week	0.6	0.7	1.4	-1.2	-0.7	-0.4
Pain experienced in last month	0.6	1.0	1.5	-0.7	1.2	1.0
Supplements: Calcium	0.6	0.6	1.6	-0.1	0.5	-1.3
Heart disease (siblings)	0.6	0.7	2.1	-0.0	-1.5	-0.3
Ovarian Cancer	0.5	0.6	0.9	1.0	-0.9	0.4
Schizophrenia (2014)	0.5	1.1	1.8	0.7	-1.0	-1.3
Systolic Blood Pressure	0.5	2.6	5.6	1.4	-0.4	2.4
Number of treatments/medications taken	0.5	0.8	2.0	0.7	-0.1	-1.4
Relative age of first facial hair	0.5	1.0	2.7	-0.6	0.3	1.6
Vitamin and mineral supplements	0.5	0.7	2.0	-0.1	-0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	-0.8	-1.0	-0.5
Supplements: Glucosamine	0.5	0.6	1.3	-0.7	0.1	-1.2
Medication: Cholesterol lowering	0.5	0.8	1.1	-0.6	-0.9	-1.0
Medication: Lansoprazole	0.5	0.6	1.5	-0.2	1.2	0.5
Length of working week for main job	0.5	0.6	1.7	-1.3	-0.1	-0.4
Birth weight of first child	0.5	0.8	1.9	-1.4	0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.1	0.1	0.5	-1.4
Had major operations	0.5	0.6	1.0	1.0	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.9	-1.1	-1.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	0.6	-0.2	-1.4
Medication: Aspirin	0.5	0.7	1.4	-0.3	-0.8	-1.2
Financial situation satisfaction	0.5	0.6	1.7	0.4	1.3	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	-0.9	0.2	-1.0
Cholesterol lowering medication	0.5	0.7	1.6	0.1	-1.3	-0.8
LDL Cholesterol	0.4	0.6	1.0	-1.0	-0.6	-0.7
Primary Biliary Cirrhosis	0.4	0.6	1.2	-1.1	-0.4	-0.7
Heel T-Score	0.4	3.6	7.2	0.4	-1.9	-2.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	1.2	0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.2	0.8	-1.0	-1.1
Medication: Levothyroxine sodium	0.4	0.7	1.3	1.1	-0.1	0.9
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	0.8	0.3	-0.9
Pain all over the body in last month	0.4	0.5	0.8	-0.7	-0.9	-0.3
Time employed in main current job	0.4	0.4	0.9	-0.3	-0.9	0.6
Father’s age at death	0.4	0.6	0.7	0.8	0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	0.9	-0.7	-1.0	0.8
Pulse rate	0.4	0.6	1.1	-0.5	-0.7	-1.1
Illnesses of mother	0.4	0.5	0.9	0.7	0.3	0.9
Headache pain in last month	0.4	0.8	1.2	1.1	-0.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.1	-0.3	-0.4	-1.1
Neck or shoulder pain in last month	0.4	0.5	1.2	0.1	-0.6	1.1
Alcohol intake frequency.	0.4	1.0	2.4	0.7	1.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	-0.6	-0.9	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.2	0.7	0.3	-1.1
Loneliness, isolation	0.4	0.6	1.0	0.8	0.4	1.0
Commuting to job workplace: Walk	0.4	0.4	0.9	0.9	0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.1	-0.8	0.8	-1.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	1.1	-0.2	-0.8
Unable to work because of sickness or disability	0.4	0.5	0.6	-0.6	0.6	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.5	-0.4	-1.0
Pack years of smoking	0.4	0.6	1.3	-0.4	0.6	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	0.7	-0.5	-0.9	-0.8
Depression (Nagel 2018)	0.3	0.5	0.8	-0.5	-0.7	-0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	0.9	-0.3	-0.0
Ulcerative Colitis (UC)	0.3	0.7	1.7	0.5	1.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.0	0.9	0.3	-1.0
Breast Cancer	0.3	0.7	2.0	-1.4	0.2	0.3
HDL Cholesterol	0.3	0.5	0.7	0.8	0.1	0.8
Blood Platelet Count	0.3	3.2	8.4	0.9	-0.7	2.9
Blood Red Count	0.3	2.8	5.3	0.5	1.6	-2.3
Waist Hip Ratio (WHR)	0.3	1.3	3.3	0.6	-0.6	-1.8
Medication for hormone replacement therapy	0.3	0.4	0.5	-0.3	-0.7	-0.7
Pack years adult smoking proportion	0.3	0.4	0.5	-0.7	0.4	0.7
Taking other prescription medications	0.3	0.5	0.7	0.8	-0.5	-0.7
Past tobacco smoking	0.3	0.5	0.6	-0.8	-0.6	-0.6
Fluid intelligence score	0.3	0.5	0.9	0.3	0.8	-0.9
Noisy workplace	0.3	0.3	0.5	0.7	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.1	-1.0	1.0	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	1.0	0.5	0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-1.0	0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	1.2	-0.6	0.3
Health satisfaction	0.3	0.4	0.8	-0.9	-0.5	-0.4
Chest pain or discomfort	0.3	0.4	0.9	0.0	-0.6	-1.0
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.5	-0.2	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.5	-0.8	-0.2
Medication: Blood pressure	0.3	0.6	1.2	1.1	0.7	0.3
Fractured/broken bones in last 5 years	0.3	0.3	0.9	-0.9	-0.2	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	-1.5	-0.1	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	0.5	0.9	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	1.0	0.3	0.2
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.6	-0.4	-0.0
Rheumatoid Arthritis	0.2	0.2	0.6	-0.8	0.3	-0.2
Blood Eosinophil Count	0.2	1.7	4.9	2.2	-0.4	-0.4
Height	0.2	3.8	6.7	-2.6	-2.1	0.7
Lung FEV1/FVC ratio	0.2	1.2	2.5	-1.6	-0.9	-0.3
Lung FVC	0.2	0.8	1.3	1.2	1.0	-0.0
Tanning	0.2	1.9	3.0	1.3	1.0	1.7
Maternal smoking around birth	0.2	0.3	0.4	0.7	-0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	0.0	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	0.7	0.9	0.2
Heart attack	0.2	0.2	0.4	0.4	-0.6	0.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.5	0.4	0.6
Lung cancer (father)	0.2	0.3	0.4	0.6	0.0	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.6	0.3	-0.4
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.7	-1.0	-0.1
Pulse wave peak to peak time	0.2	0.2	0.2	0.5	-0.3	-0.4
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.1	-0.8	0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.4	-0.8	-0.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.8	-0.1	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.7	0.2	0.4
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.0	0.9	-0.2
Average weekly beer plus cider intake	0.2	0.3	0.5	0.2	0.4	0.7
Age started oral contraceptive pill	0.2	0.2	0.4	0.5	0.1	0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.3	0.1	-0.6	1.1
Lupus	0.1	0.1	0.2	0.4	0.3	0.4
Cardiovascular Disease	0.1	0.2	0.6	0.1	0.3	-0.8
Average weekly spirits intake	0.1	0.1	0.1	-0.4	0.4	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.2	0.7	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	-0.6	-0.1	-0.3
Angina	0.1	0.1	0.2	0.4	0.4	0.2
Medication: Co-codamol	0.1	0.1	0.4	0.1	-0.1	-0.6
Average weekly fortified wine intake	0.1	0.2	0.3	0.5	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.5	0.7	0.1
High blood pressure	0.1	0.4	1.1	1.0	0.3	-0.1
Sitting height	0.1	0.8	2.2	-1.5	-0.3	0.2
Alcohol usually taken with meals	0.1	0.2	0.3	0.4	0.4	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.3	-0.3	-0.5
Had other major operations	0.1	0.2	0.4	-0.3	-0.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	-0.3	0.2
Standing height	0.1	1.1	2.8	-1.7	-0.7	-0.0
Hair/balding pattern: Pattern 4	0.1	0.4	0.5	-0.4	-0.7	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.5	0.2	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.2	-0.5	-0.3
Number of full brothers	0.1	0.1	0.4	-0.6	0.0	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.4	-0.1	0.5
Medication: Blood pressure	0.1	0.2	0.5	-0.4	-0.1	-0.7
Angina (self-reported)	0.1	0.1	0.2	0.3	0.5	0.4
Migraine (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.1
Hypertension (Self-reported)	0.1	0.3	0.5	0.7	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.2	-0.5	0.0
Medication for cholesterol	0.1	0.2	0.4	-0.6	0.4	0.2
Medication: Gliclazide	0.1	0.2	0.2	0.5	0.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.0	0.3	0.4
High cholesterol (Self-reported)	0.1	0.2	0.5	0.7	0.1	-0.2
Medication: Lisinopril	0.1	0.1	0.1	0.4	0.3	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.2	-0.6	0.1
Ulcerative Colitis	0.0	0.1	0.1	-0.1	0.3	0.3
Hair Pigment	0.0	0.2	0.5	0.7	-0.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.2	-0.0	-0.0
Medication: Atenolol	0.0	0.1	0.1	0.2	0.3	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.1	0.4	0.3	0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.1	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	-0.3	-0.2	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.1	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.2	0.2	0.4
Pulse rate, automated reading	0.0	0.1	0.2	-0.3	-0.4	-0.4
Smoking status: Previous	0.0	0.1	0.1	-0.3	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	-0.2	0.2	0.2
Mother’s age at death	0.0	0.1	0.1	-0.1	-0.1	0.4

Hub : Genes

C9orf40

Models

Trait associations