Hub : Genes

CABIN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1800	0.0440	1.1e-10	0.068	0.106	0.094	0.108	0.090	1.2e-08	7.6e-13	1.6e-11	5.2e-13	4.7e-11
2	GTEx	Cells Transformed fibroblasts	0.1280	0.0620	4.3e-03	0.034	NA	0.005	NA	0.021	1.3e-03	NA	1.2e-01	NA	9.4e-03
3	GTEx	Thyroid	0.1120	0.0430	1.1e-04	0.063	NA	0.050	NA	0.068	1.4e-05	NA	1.0e-04	NA	6.4e-06
4	METSIM	Adipose	0.1850	0.0417	5.0e-11	0.086	0.082	0.111	0.111	0.097	7.2e-13	2.7e-12	3.3e-16	3.3e-16	2.5e-14
5	YFS	Blood	0.0402	0.0138	8.4e-07	0.015	0.024	0.016	0.021	0.012	6.9e-06	1.5e-08	3.7e-06	1.1e-07	4.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	1.3	-1.0	-0.9	-0.2	-0.5	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.6	2.9	-1.7	0.4	0.1	-0.4	0.1
Depressed Affect (Nagel 2018)	1.0	2.1	4.9	-2.2	1.6	1.6	-0.6	0.4
Depression (Nagel 2018)	0.4	0.5	1.6	-0.6	0.4	1.3	-0.7	-0.3
Intelligence (Savage-Jansen 2018)	1.3	3.9	10.5	-2.3	1.8	3.2	0.0	0.8
Neuroticism (Nagel 2018)	0.3	0.7	1.9	-0.8	1.4	-0.3	-0.9	0.4
Schizophrenia (2018)	0.4	0.9	1.7	-1.3	1.3	0.3	-0.2	0.9
Schizophrenia vs Biploar Disorder	0.7	0.9	4.1	-0.3	2.0	-0.3	0.3	0.2
Worry (Nagel 2018)	0.1	0.2	0.5	0.1	0.5	0.1	-0.4	-0.7
Alzheimer’s Disease (in mother)	0.9	1.1	1.9	0.6	-1.0	1.4	0.6	1.3
Alzheimer’s Disease (in father)	0.9	1.0	2.6	-0.5	1.6	0.1	0.6	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.0	0.6	0.9	0.7	0.6
Crohns Disease (2017)	0.6	1.4	4.5	-2.1	0.5	0.1	-1.5	-0.2
Irritable Bowel Disease (IBD)	0.8	1.9	4.3	-2.1	0.3	-0.9	-2.0	0.2
Ulcerative Colitis (UC)	1.0	1.8	3.6	-1.4	0.3	-1.8	-1.9	0.6
Major Depression (MDD)	0.6	0.7	2.7	0.4	0.0	-1.7	0.2	-0.9
Reaction Time	0.6	1.2	2.2	-1.1	1.3	-1.5	-0.9	0.4
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.5	-1.7	1.5	2.3	-0.1	0.9
Breast Cancer	2.0	4.9	9.3	-3.0	2.9	1.2	-2.1	-0.5
Ovarian Cancer	0.1	0.1	0.4	-0.1	0.6	-0.2	-0.2	-0.1
Prostate Cancer	0.3	0.4	0.7	-0.8	-0.7	-0.2	-0.7	0.3
Age at First Birth	0.4	0.6	1.9	0.0	1.4	-0.8	0.0	0.8
Bipolar Disorder (2011)	1.8	1.8	3.7	-1.9	-0.4	0.0	-1.4	-1.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.8	-0.5	0.3	1.0	0.4
Coronary Artery Disease (CAD)	2.3	2.8	6.6	-2.2	2.6	0.3	-1.5	0.5
Crohns Disease (2012)	0.4	0.6	1.1	-1.0	-0.5	-0.7	-1.0	-0.4
Mean Putamen Volume	1.2	1.4	2.8	-0.7	-1.3	1.7	-0.8	-1.1
Fasting Glucose	0.7	0.8	2.1	-1.4	0.3	-1.2	0.2	0.5
HbA1C	1.3	1.5	2.6	1.5	-0.4	-1.2	1.6	0.9
HDL Cholesterol	0.5	0.8	1.5	-0.4	1.2	0.0	-1.2	0.9
LDL Cholesterol	0.5	0.8	3.5	-0.0	-0.5	0.3	0.1	-1.9
Lupus	0.4	0.7	1.8	1.4	-0.8	-0.2	0.2	-0.9
Neuroticism (2016)	0.2	0.3	0.6	-0.4	-0.6	-0.4	-0.8	-0.4
Primary Biliary Cirrhosis	0.2	0.3	1.1	-0.2	0.4	1.1	-0.0	-0.6
Rheumatoid Arthritis	0.5	0.7	1.5	-1.0	1.2	-0.3	-0.8	-0.3
Schizophrenia (2014)	0.1	0.2	0.4	-0.4	0.5	0.2	-0.1	0.6
Triglycerides	1.9	3.1	7.5	-1.7	2.7	-1.3	0.6	1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.3	-0.0	-1.8	0.1	-0.1	0.0
Ulcerative Colitis	1.0	1.4	5.2	0.8	-0.5	-2.3	-0.9	0.4
Blood Eosinophil Count	1.1	8.6	15.9	2.0	-3.9	-1.4	-4.0	-2.4
Blood Platelet Count	0.1	1.6	3.4	-1.9	0.6	1.0	-1.8	0.2
Blood Red Count	0.3	2.8	8.2	-1.2	-0.1	2.9	-0.2	2.1
Blood White Count	1.5	11.0	33.8	1.9	-5.8	-1.9	-2.4	-2.8
Heel T-Score	0.4	3.1	12.7	0.2	0.0	0.4	1.6	3.6
BMI	0.4	2.3	8.5	1.4	-1.0	0.1	-0.3	2.9
Height	0.3	4.9	11.6	2.8	-3.4	-2.0	-0.8	-0.9
Waist Hip Ratio (WHR)	0.4	1.8	5.0	-1.2	2.2	1.3	0.4	0.8
Systolic Blood Pressure	0.4	1.9	4.9	2.2	-0.5	-2.0	-0.4	0.7
Smoking Status	0.2	0.5	1.5	-0.6	0.3	1.2	0.6	0.1
Allergy or Eczema	1.0	2.5	11.8	0.3	0.6	-3.4	-0.4	-0.0
Cardiovascular Disease	0.3	0.9	1.6	-1.1	0.1	0.8	-0.9	-1.3
Hypothyroidism (self reported)	0.5	1.2	2.6	-0.2	-0.1	1.2	-1.5	1.6
Respiratory disease	0.7	1.5	3.2	0.6	-1.0	-0.8	-1.8	-1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	4.2	-0.6	-0.2	2.0	0.1	-0.1
Lung FEV1/FVC ratio	0.8	3.9	11.2	-1.9	0.8	3.3	-1.0	-1.8
Lung FVC	0.4	2.1	3.4	-1.6	1.2	1.6	-0.8	1.8
Neuroticism	0.5	1.2	2.3	-1.4	1.5	-0.1	-1.3	-0.0
Chronotype (morning person)	0.6	1.5	2.6	-0.0	0.6	-1.6	-1.6	-1.3
Hair Pigment	0.0	0.9	2.4	1.2	-0.7	-1.6	-0.2	-0.5
Tanning	0.1	1.3	3.0	1.7	-1.3	-0.0	1.2	0.7
Hand grip strength (left)	0.7	1.7	4.2	1.5	-1.4	0.3	0.3	2.0
Number of treatments/medications taken	0.3	0.6	2.4	-0.6	-0.3	1.6	-0.0	0.1
Average weekly spirits intake	0.6	0.7	1.2	0.9	-0.4	-0.9	0.8	1.1
Sensitivity / hurt feelings	0.9	1.5	5.7	0.3	0.4	-2.4	-0.5	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-1.0	0.1	0.3	-0.7	0.8
Hearing difficulty/problems: Yes	0.3	0.4	1.0	1.0	-0.4	0.7	0.3	0.5
Relative age of first facial hair	0.7	1.4	5.0	-0.7	1.1	2.2	0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.3	-0.5	0.0	-1.1	0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.0	-1.1	1.4	-0.6	0.1	-0.8
Ever had hysterectomy (womb removed)	1.4	1.6	3.5	-1.9	0.2	0.2	-1.8	-1.2
Systolic blood pressure, automated reading	1.1	3.1	6.2	2.5	-1.6	-1.9	-0.1	1.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	6.8	-2.6	0.9	0.3	0.3	-0.4
Angina	2.9	3.8	14.4	-3.8	1.6	0.8	-1.1	0.2
Medication for hormone replacement therapy	2.1	2.3	5.5	-0.1	-1.5	-1.4	-2.3	-1.3
Vitamin and mineral supplements	0.8	1.0	1.9	1.0	-1.4	-0.5	-1.2	-0.8
Supplements: Zinc	1.0	1.1	3.1	0.2	0.2	-1.0	-1.8	1.2
Medication: Co-codamol	0.2	0.3	1.1	0.2	1.1	0.1	-0.3	-0.0
Medication: Metformin	0.3	0.4	0.7	0.3	-0.7	0.6	0.8	-0.5
Diabetes (father)	0.2	0.3	0.7	-0.1	-0.2	-0.3	0.9	0.7
Diabetes (mother)	1.7	2.2	4.4	1.2	-1.4	-0.6	1.7	2.1
Severe depression (siblings)	0.6	0.7	1.8	-0.6	-1.0	0.3	-1.3	0.7
Pack years adult smoking proportion	1.6	2.4	4.8	-2.2	1.1	1.9	-0.6	1.4
Impedance of leg (right)	0.7	3.3	11.1	-2.0	3.3	-0.1	1.1	0.1
Leg fat-free mass (left)	0.9	5.0	14.8	2.9	-3.9	-0.3	-0.8	1.1
Trunk fat percentage	1.0	3.9	8.3	2.8	-1.8	-0.6	0.3	2.9
Hand grip strength (right)	0.4	1.1	2.4	1.0	-0.8	1.1	0.0	1.6
Townsend deprivation index at recruitment	0.6	0.9	3.9	0.4	0.0	-0.2	-0.6	2.0
Current tobacco smoking	0.9	1.4	4.5	-1.5	-0.4	2.1	0.1	0.5
Average weekly fortified wine intake	0.7	0.8	1.8	-0.2	0.2	-1.3	1.3	-0.9
Maternal smoking around birth	0.2	0.3	0.8	0.5	-0.9	-0.3	-0.3	0.4
Fed-up feelings	0.4	0.8	1.7	-1.3	0.6	0.3	-0.9	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.4	-0.4	0.7	0.0	0.9
Relative age voice broke	1.8	2.7	9.5	-0.7	0.0	3.1	1.2	-1.4
Taking other prescription medications	0.6	0.9	1.4	1.2	-1.1	1.2	-0.2	0.7
Age when periods started (menarche)	0.4	1.1	2.0	1.0	0.2	-1.2	0.8	1.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.5	-1.0	-0.4	-1.9	-1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	8.9	0.5	0.0	-0.8	-0.3	3.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	-1.2	1.1	-0.2	-0.7	-0.6
Qualifications: CSEs or equivalent	1.0	1.3	1.8	-0.4	-1.0	1.3	-1.3	1.3
Serious illness, injury or assault to yourself	0.7	0.8	1.8	-0.8	0.4	-0.7	-1.3	0.9
High blood pressure	0.2	0.5	1.7	0.2	-1.3	-0.3	-0.6	0.6
Hayfever, allergic rhinitis or eczema	1.3	2.9	12.4	0.9	0.8	-3.5	0.6	0.4
Multivitamins +/- minerals	0.5	0.6	1.3	-0.1	0.4	1.1	1.0	0.7
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.7	-1.0	-0.2	0.1	0.6
Supplements: Glucosamine	1.1	1.4	3.8	-0.8	1.9	1.2	-0.6	1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	0.1	0.6	0.1	0.2	-0.9
Medication: Atenolol	1.1	1.4	5.5	-2.3	1.1	0.1	-0.5	-0.4
Medication: Levothyroxine sodium	0.6	1.1	2.8	0.5	-1.2	-0.2	-1.7	0.9
Sitting height	0.4	2.6	8.0	1.1	-2.8	-0.3	-1.7	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	0.8	-0.8	-0.3	-0.2	-0.9
High blood pressure (mother)	0.5	0.7	1.4	0.9	0.1	-1.2	0.6	0.9
Body mass index (BMI)	0.8	3.3	6.0	2.2	-2.5	0.6	0.1	2.3
Impedance of leg (left)	0.6	2.8	9.1	-1.8	3.0	-0.4	1.3	0.1
Leg predicted mass (left)	1.0	5.1	14.9	2.9	-3.9	-0.2	-0.7	1.2
Trunk fat mass	1.3	5.5	10.3	3.2	-3.0	-0.5	0.1	2.8
Waist circumference	0.8	2.9	5.7	2.0	-2.4	0.9	0.1	1.9
Number of incorrect matches in round	0.2	0.3	0.6	-0.8	-0.8	-0.4	0.2	0.4
Past tobacco smoking	0.2	0.4	0.9	-0.8	0.5	-0.4	0.9	0.0
Alcohol usually taken with meals	0.9	1.4	4.7	-0.3	-0.9	2.2	0.8	-0.9
Nervous feelings	0.4	0.8	1.7	1.3	-0.7	-0.9	-0.8	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.4	0.3	-0.1	-0.3	1.3
Hearing difficulty/problems with background noise	0.3	0.4	2.0	-0.2	0.1	0.3	-1.4	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.1	-0.1	-0.9	-0.8	0.1
Had menopause	0.9	1.1	2.9	-1.7	1.1	0.0	-0.6	-1.0
Had other major operations	0.3	0.4	1.3	0.3	-0.8	0.2	1.2	0.1
Forced vital capacity (FVC)	0.2	0.9	3.1	-0.9	0.5	0.5	-1.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	4.4	0.1	-0.2	-0.2	0.0	2.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.9	-0.1	-0.2	-0.4	-2.2	-0.4
Qualifications: None of the above	0.4	0.9	3.0	0.5	-1.7	-0.6	-0.5	0.6
Financial difficulties in last 2 years	1.0	1.3	6.2	-0.4	-0.5	2.5	-0.1	0.1
Mouth/teeth dental problems	2.4	3.7	10.1	0.2	-2.3	0.0	-1.7	-3.2
Heart attack	1.9	2.4	9.1	-3.0	0.6	0.9	-1.0	-0.9
Allergy	1.3	3.1	12.9	-1.5	0.0	3.6	0.4	-0.0
Pain all over the body in last month	1.2	1.3	4.4	1.2	-0.4	-2.1	-0.3	-0.5
Diabetes (self-reported)	0.6	1.0	1.8	-1.3	0.7	1.1	-1.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.0	1.7	-1.2	-0.7	0.1	0.6
Medication: Ramipril	0.9	1.2	3.5	-0.2	0.8	0.4	1.3	1.9
Medication: Simvastatin	0.8	1.2	3.2	-1.8	1.0	0.2	-1.2	0.5
Fluid intelligence score	0.6	1.3	1.9	-0.7	1.1	1.3	1.2	1.4
Illnesses of siblings	0.5	0.7	1.4	-0.3	-0.6	1.2	0.6	-1.1
Neuroticism score	0.4	0.9	2.9	-0.9	0.7	-0.3	-1.7	0.2
Weight	1.1	5.5	14.4	3.1	-3.8	0.0	-0.4	1.9
Impedance of arm (right)	0.4	2.1	3.9	0.2	2.0	-1.7	-0.9	-1.6
Arm fat percentage (right)	0.8	3.2	6.8	2.6	-1.9	-0.1	-0.7	2.3
Trunk fat-free mass	0.7	4.2	16.2	2.1	-4.0	0.4	-0.5	0.6
Hip circumference	1.4	5.9	14.1	3.6	-3.8	-0.2	0.2	1.5
Time employed in main current job	1.2	1.4	4.6	-0.3	0.9	-0.9	2.2	0.7
Alcohol intake versus 10 years previously	2.0	2.9	8.8	-2.2	0.9	3.0	0.5	0.2
Father’s age at death	0.3	0.4	1.4	0.4	0.1	0.5	0.2	-1.2
Worrier / anxious feelings	0.4	0.8	2.0	-0.0	1.0	-1.4	-0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-0.1	-0.7	-1.1	-1.2	0.9
Falls in the last year	0.7	0.9	1.5	0.8	-1.2	1.0	-0.3	1.1
Hair/balding pattern: Pattern 3	0.9	1.4	3.9	0.8	0.2	-0.5	2.0	1.4
Number of live births	1.1	1.5	4.8	1.3	-2.2	0.6	0.9	-0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.6	-1.6	0.9	1.6	-1.4	-0.4
Pulse rate	0.9	1.5	4.6	-1.0	0.3	2.1	0.3	1.3
Happiness	0.4	0.4	0.9	-1.0	-0.8	-0.2	-0.8	-0.1
Noisy workplace	0.8	1.0	3.0	0.7	-0.3	-1.7	-0.7	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	-0.2	1.1	0.0	-1.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.7	1.6	0.3	0.1	0.5
Mouth/teeth dental problems: Dentures	0.8	1.3	4.5	1.2	-0.4	-0.7	0.3	2.1
Asthma	0.2	0.5	1.3	0.2	-0.8	-0.2	-1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.8	0.6	-0.2	-1.4	1.0	0.1
Medication: Cholesterol lowering	2.4	3.7	7.9	-2.7	-0.1	2.8	-1.0	-1.6
Depression (self-reported)	0.8	1.0	1.6	-0.5	1.3	1.1	-1.2	-0.7
Medication: Lansoprazole	4.2	4.8	11.5	-0.1	-1.6	1.8	-3.4	-2.5
Prospective memory result	0.7	0.8	1.3	1.1	-0.7	-0.8	-0.9	-1.0
Lung cancer (father)	1.1	1.3	2.5	1.3	-1.4	0.4	-0.4	-1.6
Illnesses of mother	1.0	1.2	1.9	-1.0	0.1	1.4	-1.1	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.5	-1.0	0.4	2.1	-0.7	-0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.8	0.2	-0.2	-1.0	-1.3	0.9
Impedance of arm (left)	0.3	1.6	3.4	0.5	1.6	-1.9	-0.7	-1.1
Arm fat mass (right)	1.1	4.4	8.0	2.8	-2.8	-0.1	-0.6	2.4
Trunk predicted mass	0.7	4.1	15.5	2.1	-3.9	0.3	-0.5	0.5
Standing height	0.4	3.6	11.2	2.1	-3.4	-1.4	-0.8	-0.4
Length of working week for main job	0.4	0.4	1.0	-0.9	-0.3	0.5	-1.0	-0.0
Exposure to tobacco smoke at home	0.3	0.4	0.8	-0.7	-0.2	-0.6	-0.9	-0.5
Breastfed as a baby	1.3	1.6	3.5	-1.4	0.7	-0.2	-1.9	1.6
Tense / ‘highly strung’	0.6	1.0	1.5	0.9	-1.0	-1.2	0.8	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.9	0.9	0.6	-0.6	0.6	1.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.3	-0.1	-0.3	-0.4	-1.2	-1.5
Birth weight of first child	1.2	2.3	5.7	1.2	0.3	-2.4	1.3	1.5
Peak expiratory flow (PEF)	1.9	4.3	14.3	-1.8	0.3	3.8	-1.5	-1.3
Pulse wave reflection index	0.7	0.9	2.6	-0.4	0.2	-0.6	-1.6	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.2	0.2	-0.2	0.1	0.5	-1.1
Loud music exposure frequency	0.1	0.1	0.4	-0.1	-0.3	0.6	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	7.3	-0.1	1.5	-2.0	-0.6	2.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	0.3	1.4	-1.6	0.6	1.1
Blood clot in the leg (DVT)	1.2	1.5	4.0	1.3	-2.0	-1.2	-0.8	-0.1
Medication: Paracetamol	0.2	0.3	0.8	0.4	-0.4	-0.3	0.9	-0.3
Headache pain in last month	0.8	1.3	3.0	0.9	0.7	-1.7	0.5	1.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.0	1.7	0.8	-2.2	0.3	0.4
Glaucoma (self-reported)	0.4	0.5	1.3	0.5	-0.7	-0.6	0.1	1.1
Gout (self-reported)	0.9	1.2	5.0	0.1	-0.1	-1.1	0.1	-2.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.0	0.9	-1.4	0.5	-1.4	1.3
Medication: Amlodipine	0.3	0.5	1.2	-0.5	1.1	0.3	-0.5	0.7
Medication: Ventolin 100micrograms inhaler	1.7	2.1	5.9	-0.7	-1.4	1.3	-2.4	0.7
Birth weight	1.4	2.9	7.6	-0.4	0.9	-2.2	-1.2	2.8
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.7	2.2	-1.6	-1.4	0.6	-1.0
High blood pressure (siblings)	0.1	0.1	0.4	0.3	0.6	-0.3	0.1	0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-0.3	-0.2	0.7	-1.4	-0.2
Body fat percentage	0.8	3.3	8.3	2.4	-1.6	-0.1	0.2	2.9
Leg fat percentage (right)	0.6	2.1	7.1	1.2	-0.8	0.8	0.7	2.7
Arm fat-free mass (right)	0.9	4.9	15.1	2.1	-3.9	0.5	0.3	2.1
Exposure to tobacco smoke outside home	0.8	1.0	1.6	-1.0	0.5	1.1	-1.0	-1.3
Comparative body size at age 10	0.3	0.7	1.6	1.1	-1.3	-0.1	0.8	-0.3
Number of full brothers	0.7	0.9	2.8	-0.2	-1.7	-0.9	0.9	0.3
Worry too long after embarrassment	1.7	2.9	8.1	1.3	-1.1	-2.9	-1.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-0.8	0.5	1.0	-0.9	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	0.1	-0.7	0.5	-0.1	1.0
Number of children fathered	1.0	1.1	2.9	1.7	-0.9	-0.9	0.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.1	1.8	-1.6	-1.2	0.1	-0.7
Age at first live birth	1.7	3.1	12.1	-1.4	3.5	0.0	1.0	-0.5
Pulse wave peak to peak time	0.5	0.6	1.8	0.1	-0.0	0.7	1.3	-0.9
Health satisfaction	0.3	0.4	1.1	-0.6	0.3	-0.2	-1.1	0.6
Shortness of breath walking on level ground	0.7	0.8	2.6	1.6	-0.9	-0.8	0.1	-0.3
Qualifications: College or University degree	0.3	0.9	3.5	-0.2	0.9	0.3	1.9	-0.4
Eye problems/disorders: None of the above	0.3	0.3	0.5	-0.6	0.4	0.7	-0.5	-0.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	8.8	1.1	-1.3	0.2	3.0	0.6
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.3	-0.8	-0.5	0.7	0.3
Medication for pain relief, constipation, heartburn	0.3	0.6	2.1	0.7	0.1	0.0	-0.6	1.4
Neck or shoulder pain in last month	1.1	1.5	5.8	-0.3	-0.6	-0.7	-1.0	2.4
Medication: Blood pressure	0.5	0.9	2.2	-1.5	-0.5	1.3	0.5	0.7
Angina (self-reported)	2.8	3.6	14.0	-3.7	1.7	0.7	-0.9	0.3
Migraine (self-reported)	0.5	0.6	2.4	-0.2	0.1	0.4	0.6	-1.6
Medication: Ibuprofen	0.3	0.4	1.6	0.4	0.0	-1.3	0.3	0.3
Medication: Allopurinol	0.7	0.9	2.5	0.6	-0.3	-0.6	1.0	-1.6
Medication: Omeprazole	0.3	0.4	0.7	-0.8	-0.1	0.6	0.8	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.2	0.7	-1.5	-0.2	-0.3	0.4
Mean time to correctly identify matches	0.7	1.3	2.9	-1.2	1.2	-1.7	-0.9	0.4
Heart disease (mother)	1.2	1.4	3.8	0.1	1.5	-2.0	-0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.7	0.2	-0.5	0.3	0.2	-1.3
Whole body fat mass	1.2	4.8	8.5	2.9	-2.9	-0.3	0.1	2.7
Leg fat mass (right)	0.9	3.7	7.3	2.3	-2.4	0.3	0.3	2.7
Arm predicted mass (right)	0.8	4.2	12.5	2.0	-3.5	0.4	0.3	2.1
Pulse rate, automated reading	0.5	1.6	4.3	-1.5	0.5	2.1	-0.3	1.1
Alcohol intake frequency.	1.4	3.3	8.5	-2.9	0.6	1.4	-0.6	2.3
Comparative height size at age 10	0.2	1.4	3.4	0.1	-1.8	-0.9	-1.5	0.6
Number of full sisters	1.3	1.5	2.8	-0.8	-1.2	1.7	-1.6	-0.4
Suffer from ‘nerves’	0.1	0.2	0.9	1.0	0.1	0.0	0.3	-0.3
Overall health rating	1.0	2.2	4.4	-0.0	-2.1	-1.9	-1.2	1.4
Chest pain or discomfort	0.6	0.9	2.8	-1.1	0.6	0.2	-0.5	1.7
Had major operations	2.1	2.5	8.4	-0.1	-0.4	1.8	-0.7	-2.9
Age at last live birth	1.9	2.8	8.8	-1.6	3.0	0.7	0.3	-1.4
Family relationship satisfaction	1.0	1.2	2.8	-1.6	0.6	0.2	-1.7	-0.4
Leg pain on walking	0.8	0.9	3.4	0.3	-1.0	-0.1	0.4	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	0.4	-0.0	1.3	-0.1	1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	1.1	-0.4	-1.1	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.3	-0.1	0.8	1.2	-0.9
Medication: Aspirin	2.9	3.8	8.8	-2.7	-0.1	3.0	-0.0	-1.7
Supplements: Vitamin C	1.6	1.9	6.1	-2.5	0.8	1.1	-1.2	-0.3
Knee pain experienced in last month	0.2	0.4	0.9	0.2	-0.4	1.0	0.6	0.7
Hypertension (Self-reported)	0.2	0.4	1.5	0.1	-1.2	-0.1	-0.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	-0.7	-0.3	1.1	-0.7	-1.1
Illnesses of father: Heart disease	0.9	1.2	2.3	-1.4	1.2	0.5	0.5	1.5
Illnesses of siblings: Diabetes	0.7	0.8	1.4	0.6	-1.2	-0.3	-0.9	1.2
Smoking status: Previous	0.2	0.3	0.9	0.9	-0.2	-0.3	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	0.6	-0.7	-0.1	0.5	1.2
Whole body fat-free mass	0.9	4.9	16.8	2.6	-4.1	0.1	-0.5	0.9
Leg fat-free mass (right)	1.0	5.3	16.4	2.9	-4.0	-0.3	-0.8	0.8
Arm fat percentage (left)	0.9	3.6	7.5	2.6	-2.0	0.0	-0.5	2.7
Average weekly red wine intake	2.1	3.1	5.8	1.0	-2.4	1.2	1.7	-2.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-0.2	-0.8	1.2	-0.6	-1.3
Mood swings	1.4	2.6	5.6	-1.7	0.8	0.2	-2.4	2.0
Loneliness, isolation	0.7	1.0	2.4	-1.4	0.2	-0.0	-0.8	1.6
Long-standing illness, disability or infirmity	1.2	1.9	3.6	-1.2	0.5	1.9	-1.3	1.5
Ever had bowel cancer screening	0.6	0.7	1.4	-0.8	1.1	1.2	-0.1	-0.5
Diabetes diagnosed by doctor	0.6	0.9	2.8	-1.3	-0.2	1.7	-0.5	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.6	-0.1	-0.3	-0.3	-1.0
Friendships satisfaction	0.1	0.1	0.2	-0.5	0.0	0.1	-0.1	0.5
Qualifications: nursing, teaching	0.5	0.7	2.4	-1.0	0.3	1.5	-0.3	-0.2
Commuting to job workplace: Walk	0.9	1.0	2.3	-0.2	0.6	1.5	1.2	0.8
Eye problems/disorders: Cataract	0.8	0.9	2.2	1.1	-0.4	-0.9	1.5	0.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.6	-0.8	1.9	1.3	-0.5	1.6
Medication for cholesterol	1.2	1.9	4.0	0.7	1.1	1.3	2.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	1.2	0.1	-1.1	-0.5	0.1
Back pain experienced in last month	0.2	0.3	0.7	0.3	-0.6	-0.8	-0.3	0.5
Mineral and other dietary supplements	1.3	1.8	4.0	0.4	-2.0	1.0	-0.8	-1.7
Breast cancer (self-reported)	0.2	0.3	0.6	0.2	-0.4	-0.6	-0.6	-0.8
Asthma (self-reported)	0.3	0.6	1.5	0.4	-0.8	-0.6	-1.2	-0.6
Osteoporosis (self-reported)	0.8	1.0	4.1	-0.5	-0.6	2.0	0.5	-0.4
Osteoarthritis (self-reported)	1.6	2.1	4.0	0.6	-2.0	1.6	1.8	-0.7
Medication: Aspirin	2.8	3.6	9.3	-2.6	-0.1	3.0	-0.3	-1.4
Medication: Gliclazide	0.4	0.5	0.9	-0.5	0.6	-0.1	0.9	0.9
Illnesses of father: None of the above (group 1)	0.5	0.7	1.2	1.1	-1.0	-1.1	-0.1	0.1
Smoking status: Current	0.8	1.3	3.8	-1.5	-0.3	1.9	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.9	-1.0	1.2	1.7	0.4	0.8
Whole body water mass	0.8	4.7	16.0	2.5	-4.0	0.1	-0.6	1.0
Leg predicted mass (right)	1.0	5.3	16.5	2.9	-4.1	-0.3	-0.8	0.8
Arm fat mass (left)	1.1	4.4	8.8	2.7	-3.0	-0.1	-0.6	2.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-0.3	-1.0	0.7	-0.2	0.5
Average weekly champagne plus white wine intake	1.7	2.3	7.3	-0.3	-0.2	0.7	-2.7	-1.9
Miserableness	1.1	2.0	3.4	-1.6	1.5	0.6	-1.2	1.8
Guilty feelings	0.8	1.2	2.9	-1.1	0.9	-1.1	-1.7	0.1
Wears glasses or contact lenses	0.6	0.7	1.9	-0.9	0.3	1.4	0.5	-0.6
Ever taken oral contraceptive pill	0.9	1.0	2.5	-0.9	1.0	1.6	-0.9	0.5
Hearing aid user	0.7	0.8	2.4	-0.5	0.7	-0.1	-1.0	1.6
Mother’s age at death	0.7	0.9	1.8	0.7	-0.4	1.0	1.3	0.9
Financial situation satisfaction	0.3	0.4	0.9	-0.7	-0.3	0.5	-0.2	-1.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.6	-0.2	0.1	-0.8	0.1	-0.2
Commuting to job workplace: Public transport	1.6	1.9	3.1	-1.8	0.7	1.5	1.6	-1.0
Eye problems/disorders: Glaucoma	2.3	2.7	4.4	2.1	-1.6	-2.0	-0.7	1.4
Medication: Blood pressure	0.7	1.3	4.2	0.2	-0.4	-1.4	-0.7	-2.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.8	1.7	-0.4	0.4	1.1	1.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.7	0.5	1.4	-1.3	1.6	1.1
High cholesterol (Self-reported)	1.9	3.3	8.9	-2.0	0.1	3.0	-1.5	-1.2
Medication: Bendroflumethiazide	0.6	0.9	2.0	1.4	-0.9	-1.1	-0.8	0.3
Medication: Paracetamol	0.4	0.5	1.1	0.7	-1.0	-0.1	1.1	-0.4
Medication: Lisinopril	0.4	0.5	0.8	-0.8	0.6	-0.9	-0.1	-0.7
Medication: Atorvastatin	0.6	0.7	1.6	-1.1	-0.2	1.3	-0.7	-0.2
Illnesses of father: High blood pressure	1.4	1.7	6.6	0.0	-0.4	2.6	0.3	1.3
Alcohol drinker status: Never	0.2	0.2	0.7	-0.4	-0.4	-0.8	0.2	0.1
Ever smoked	0.1	0.2	0.4	0.6	-0.4	0.2	-0.5	0.4
Basal metabolic rate	0.9	5.2	16.4	2.8	-4.0	-0.0	-0.6	1.2
Leg fat percentage (left)	0.7	2.4	7.8	1.4	-1.1	0.5	0.7	2.8
Arm fat-free mass (left)	0.8	4.0	12.9	2.1	-3.6	-0.0	-0.3	1.6
Number of operations (self-reported)	0.8	1.2	2.5	-1.0	-0.0	-0.2	-1.5	-1.6
Average weekly beer plus cider intake	0.5	0.7	1.8	1.3	-0.1	-0.5	1.3	0.3
Irritability	0.5	0.8	2.5	-0.1	1.6	1.0	-0.3	0.5
Risk taking	0.3	0.4	1.8	0.2	0.1	0.3	0.4	1.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	-0.5	0.8	-0.5	-1.2	0.8
Fractured/broken bones in last 5 years	0.7	0.9	2.4	-0.7	0.3	1.5	0.2	-1.2
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	0.6	-0.2	0.2	-0.5
Diastolic blood pressure, automated reading	0.9	2.7	8.2	1.6	-1.2	-1.3	-0.1	2.9
Ever depressed for a whole week	0.9	1.1	5.2	-0.5	0.2	-0.4	-2.3	0.1
Unable to work because of sickness or disability	0.4	0.6	1.7	0.8	-0.5	0.1	-0.4	1.3
Commuting to job workplace: Cycle	1.7	2.1	7.0	-0.9	0.6	1.2	-0.8	-2.6
Myopia	0.8	1.2	3.8	-0.8	0.1	1.0	1.9	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	0.9	1.0	0.2	1.0	-0.2
Cholesterol lowering medication	0.8	1.1	2.3	-1.5	1.2	0.1	-1.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.4	-0.9	-0.8	0.4	-0.4
Pain experienced in last month	1.1	1.8	6.2	-0.6	-0.1	2.5	1.0	-1.1
Supplements: Calcium	0.3	0.3	0.6	-0.6	0.6	0.4	-0.8	0.1
Basal cell carcinoma (self-reported)	1.6	1.9	5.2	2.0	-2.3	-0.4	-0.3	-0.0
Heart attack/myocardial infarction (self-reported)	1.8	2.3	9.0	-3.0	0.7	1.0	-0.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.4	1.2	-2.1	-1.3	-0.8	-0.1
Heart disease (siblings)	2.3	2.9	6.4	-2.1	1.7	-0.6	-0.3	2.5
Alcohol drinker status: Previous	0.5	0.6	1.2	0.0	-0.9	0.5	0.8	1.1
Pack years of smoking	1.3	1.9	3.5	-1.8	1.1	1.9	-0.5	1.2
Impedance of whole body	0.3	1.5	5.3	-0.4	2.3	-1.3	0.2	-0.5
Leg fat mass (left)	1.0	3.8	7.7	2.3	-2.5	0.1	0.3	2.8
Arm predicted mass (left)	0.8	4.2	12.5	2.3	-3.5	0.1	0.3	1.7