TWAS hub - CAND1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0250	8.4e-05	0.052	0.037	0.049	0.045	0.056	5.2e-07	2.4e-05	1.2e-06	3.0e-06	2.3e-07
2	GTEx	Adipose Subcutaneous	0.1060	0.0340	7.3e-05	0.058	NA	0.041	NA	0.050	1.6e-05	NA	2.4e-04	NA	6.4e-05
3	GTEx	Artery Tibial	0.0660	0.0267	2.3e-03	0.029	NA	0.024	NA	0.031	2.5e-03	NA	5.0e-03	NA	1.7e-03
4	GTEx	Breast Mammary Tissue	0.1210	0.0490	2.0e-03	0.037	NA	0.027	NA	0.037	5.6e-03	NA	1.6e-02	NA	5.4e-03
5	GTEx	Breast Mammary Tissue (Male)	0.1857	0.0802	1.1e-02	0.174	NA	0.125	NA	0.113	7.7e-05	NA	8.3e-04	NA	1.5e-03
6	GTEx	Colon Transverse	0.1050	0.0470	8.6e-03	0.032	NA	0.015	NA	0.026	1.2e-02	NA	5.9e-02	NA	2.1e-02
7	GTEx	Lung	0.1072	0.0483	5.8e-03	0.000	NA	-0.002	NA	0.002	3.1e-01	NA	5.3e-01	NA	2.2e-01
8	GTEx	Nerve Tibial	0.1474	0.0377	1.0e-08	0.156	NA	0.165	NA	0.161	3.5e-11	NA	9.4e-12	NA	1.8e-11
9	GTEx	Skin Not Sun Exposed Suprapubic	0.1810	0.0490	2.3e-07	0.197	NA	0.178	NA	0.177	5.1e-11	NA	4.7e-10	NA	5.2e-10
10	GTEx	Skin Sun Exposed Lower leg	0.0930	0.0290	2.9e-05	0.087	NA	0.063	NA	0.089	1.0e-07	NA	6.4e-06	NA	8.0e-08
11	METSIM	Adipose	0.0394	0.0160	1.1e-03	0.031	0.020	0.024	0.021	0.028	1.5e-05	4.3e-04	1.5e-04	3.2e-04	4.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Financial difficulties in last 2 years	9.1	12.2	15.8	-4.0	-3.5	-3.5	-3.8	-3.3	-3.8	-2.9	-3.2	-3.1	-3.6	-3.7
High blood pressure	8.6	23.9	30.5	-5.5	-5.5	-5.3	-5.0	-4.5	-4.2	-5.2	-4.6	-4.9	-4.3	-4.7
Gout (self-reported)	6.4	8.8	11.0	-3.1	-3.0	-3.0	-2.9	-3.3	-3.1	-2.1	-2.9	-3.1	-2.9	-3.0
Vascular/heart problems diagnosed by doctor	6.4	17.4	23.2	4.8	4.4	4.5	4.3	3.7	3.7	4.6	3.6	4.1	3.8	4.1
Hypertension (Self-reported)	6.3	17.6	23.0	-4.8	-4.6	-4.5	-4.2	-3.8	-3.5	-4.6	-3.8	-4.3	-3.7	-4.0
Number of full brothers	6.2	7.7	9.3	-2.8	-2.9	-3.0	-2.5	-3.0	-2.3	-2.8	-2.7	-2.9	-2.9	-2.6
Medication for cholesterol	5.8	8.8	13.8	3.4	3.7	3.2	3.0	2.8	2.4	2.8	2.9	2.9	2.5	2.7
Illnesses of siblings	5.4	7.6	8.8	2.8	2.7	3.0	3.0	2.6	2.8	2.6	2.7	2.6	2.8	2.9
Cardiovascular Disease	4.5	14.9	21.7	-4.7	-4.1	-4.0	-4.0	-3.3	-3.4	-4.2	-3.5	-3.8	-3.4	-3.8
Medication: Blood pressure	4.5	8.6	13.2	-3.2	-3.6	-3.2	-3.0	-2.9	-2.5	-2.7	-2.7	-2.8	-2.6	-2.8
Alzheimer’s Disease (in mother)	4.3	5.1	6.0	2.1	2.4	2.4	2.4	2.3	2.2	2.0	2.2	2.1	2.5	2.3
High blood pressure (siblings)	4.3	6.3	8.9	-2.5	-2.7	-2.7	-2.6	-2.6	-2.4	-2.0	-3.0	-2.0	-2.3	-2.5
Worry (Nagel 2018)	4.1	8.6	10.9	-3.0	-3.0	-3.2	-3.2	-3.1	-3.3	-2.2	-2.6	-2.1	-3.1	-3.3
Ever had prostate specific antigen (PSA) test	4.1	4.7	6.4	2.2	2.3	2.1	2.4	1.5	2.3	1.6	2.5	2.0	2.4	2.3
Rheumatoid Arthritis	4.0	5.5	6.8	-2.4	-2.6	-2.3	-2.6	-2.4	-2.6	-1.5	-2.2	-2.1	-2.4	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.0	4.6	6.2	-2.3	-2.0	-1.9	-2.3	-1.6	-2.2	-2.4	-1.8	-2.5	-2.4	-2.2
Bipolar Disorder (2018)	3.9	6.2	7.9	2.5	2.4	2.5	2.7	2.1	2.6	2.7	1.8	2.6	2.8	2.7
Medication: Ventolin 100micrograms inhaler	3.9	5.0	7.3	-2.3	-2.0	-2.3	-2.3	-2.7	-2.6	-1.7	-2.1	-1.9	-2.2	-2.3
High cholesterol (Self-reported)	3.8	6.7	11.4	-3.0	-2.5	-2.7	-2.7	-1.8	-2.2	-3.4	-2.0	-2.7	-2.6	-2.5
Cholesterol lowering medication	3.8	5.6	10.1	-3.0	-2.5	-2.5	-2.4	-1.6	-1.8	-3.2	-2.2	-2.4	-2.1	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.6	6.7	-2.3	-2.3	-2.5	-2.6	-2.6	-2.5	-1.9	-2.0	-2.5	-2.2	-2.6
Alzheimer’s Disease (including proxy)	3.6	5.2	7.4	2.0	2.4	2.4	2.4	2.7	2.6	0.8	2.7	1.8	2.4	2.4
Worry too long after embarrassment	3.6	6.1	10.5	2.7	2.1	2.5	2.4	2.3	2.4	3.2	1.7	2.5	2.6	2.5
Father’s age at death	3.5	4.6	6.1	2.4	1.9	2.4	2.4	1.7	2.2	2.2	1.5	2.0	2.3	2.5
Number of self-reported non-cancer illnesses	3.4	5.9	8.0	-2.2	-2.5	-2.6	-2.4	-2.8	-2.4	-2.4	-2.0	-2.3	-2.4	-2.5
Prospective memory result	3.3	4.0	5.8	2.4	2.1	2.0	2.1	1.8	2.0	1.7	1.6	2.2	2.0	2.0
Medication: Simvastatin	3.2	4.7	7.8	-2.3	-2.0	-2.3	-2.2	-1.9	-2.0	-2.8	-1.6	-2.3	-2.1	-2.2
Asthma	3.1	6.1	7.5	-2.7	-2.7	-2.7	-2.6	-2.5	-2.3	-2.4	-1.9	-2.5	-2.1	-2.6
Asthma (self-reported)	3.1	6.3	7.8	-2.8	-2.8	-2.8	-2.6	-2.2	-2.2	-2.7	-1.8	-2.6	-2.2	-2.6
Alzheimer’s Disease (in father)	2.9	3.2	6.1	1.5	1.8	2.0	1.8	2.2	1.9	0.2	2.5	1.5	1.4	1.8
Taking other prescription medications	2.9	4.5	5.6	-2.0	-2.3	-2.3	-2.2	-2.2	-2.2	-1.5	-1.7	-2.1	-2.4	-2.3
Number of live births	2.9	4.1	5.4	-2.1	-2.2	-2.0	-1.9	-2.2	-1.9	-1.9	-2.3	-1.8	-1.9	-1.9
Noisy workplace	2.9	3.5	5.3	1.8	2.0	2.0	1.7	2.2	1.9	1.1	2.3	1.8	2.0	1.8
Systolic blood pressure, automated reading	2.8	8.1	9.6	-3.0	-3.1	-3.0	-2.7	-3.1	-2.5	-2.9	-2.5	-2.6	-2.9	-2.7
Medication: Allopurinol	2.8	3.7	4.7	-2.2	-1.7	-1.8	-1.8	-2.0	-2.0	-1.7	-1.6	-2.0	-2.1	-2.0
Had other major operations	2.7	3.2	5.2	-1.5	-1.6	-1.9	-1.8	-2.3	-1.9	-2.0	-1.1	-1.6	-2.1	-1.8
Medication: Amlodipine	2.7	3.8	5.4	-2.1	-2.0	-1.9	-1.9	-1.9	-1.8	-2.3	-1.5	-1.8	-2.0	-1.9
Age at last live birth	2.7	3.9	4.8	2.1	2.1	2.2	2.1	1.8	1.8	1.9	1.5	2.0	2.0	2.0
Hayfever, allergic rhinitis or eczema	2.6	5.6	7.3	-2.5	-2.2	-2.3	-2.6	-2.1	-2.7	-1.5	-2.2	-2.6	-2.4	-2.6
Nervous feelings	2.6	4.9	5.9	-2.3	-2.1	-2.3	-2.4	-2.1	-2.4	-2.1	-2.1	-1.9	-2.2	-2.4
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	3.9	-1.8	-1.6	-1.7	-1.8	-1.5	-1.7	-1.9	-1.6	-1.9	-2.0	-1.8
Schizophrenia (2018)	2.5	5.2	8.5	-2.5	-1.9	-2.2	-2.4	-2.3	-2.6	-1.8	-1.8	-2.0	-2.9	-2.5
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	4.0	1.8	1.7	1.9	1.8	1.4	1.7	1.4	1.4	2.0	1.9	1.7
Tense / ‘highly strung’	2.5	4.2	6.3	-2.0	-1.6	-2.0	-2.4	-2.1	-2.5	-1.2	-2.2	-1.4	-2.2	-2.4
Medication: Omeprazole	2.5	2.9	4.0	-1.6	-1.5	-1.7	-1.7	-2.0	-1.8	-1.7	-1.6	-1.6	-1.9	-1.7
Suffer from ‘nerves’	2.5	4.0	5.7	-2.1	-1.6	-2.1	-2.2	-1.8	-2.3	-1.8	-1.6	-1.5	-2.4	-2.4
Allergy or Eczema	2.4	6.2	8.2	-2.6	-2.4	-2.5	-2.7	-2.2	-2.7	-2.0	-2.2	-2.9	-2.5	-2.6
High blood pressure (mother)	2.4	3.4	5.4	-2.1	-2.0	-2.0	-2.0	-1.5	-1.6	-2.3	-1.3	-1.6	-1.7	-1.9
Age started oral contraceptive pill	2.4	3.1	4.1	2.0	1.8	1.8	1.9	1.5	1.7	1.8	1.6	1.6	1.6	1.8
Falls in the last year	2.3	3.1	5.7	1.7	1.5	1.8	1.8	1.2	1.6	2.1	1.4	2.4	2.0	1.6
Wheeze or whistling in the chest in last year	2.2	4.0	5.0	-2.2	-2.1	-2.2	-2.1	-1.8	-1.9	-2.2	-1.2	-2.0	-1.9	-2.2
Hearing difficulty/problems: Yes	2.1	3.2	5.3	1.7	1.9	2.0	1.8	2.3	1.9	0.8	1.9	1.3	1.7	1.8
Alcohol usually taken with meals	2.1	3.4	4.9	1.6	1.8	1.9	2.0	1.7	2.0	1.6	2.2	1.2	2.0	2.1
Hearing difficulty/problems with background noise	2.1	3.4	4.3	1.8	1.6	1.9	1.8	2.1	1.8	1.7	2.0	1.7	1.9	1.9
Allergy	2.1	4.8	6.3	2.2	2.3	2.4	2.4	2.5	2.5	1.3	1.7	2.0	2.1	2.4
Ever highly irritable/argumentative for 2 days	2.0	2.4	3.0	-1.7	-1.7	-1.5	-1.7	-1.2	-1.7	-1.1	-1.3	-1.6	-1.6	-1.6
Average weekly champagne plus white wine intake	2.0	2.7	4.8	1.6	1.9	1.7	1.8	1.9	2.2	0.3	1.1	0.8	1.9	2.0
Respiratory disease	1.9	4.2	5.8	-2.2	-2.4	-2.3	-2.1	-1.8	-1.9	-2.2	-1.1	-2.1	-2.0	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	3.3	1.4	1.3	1.7	1.6	1.6	1.4	1.8	1.1	1.8	1.7	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.2	-1.2	-1.3	-1.4	-1.8	-1.8	-2.0	-1.3	-1.2	-1.2	-1.9	-2.0
Schizophrenia (2014)	1.8	3.9	5.9	-2.3	-1.8	-2.0	-2.1	-1.7	-2.0	-1.6	-1.7	-2.0	-2.4	-1.9
Qualifications: None of the above	1.7	3.7	5.1	-1.9	-2.0	-1.9	-2.0	-2.2	-2.2	-1.2	-1.7	-1.2	-2.3	-2.2
Comparative body size at age 10	1.7	4.7	8.1	2.2	2.9	2.5	2.1	2.6	1.6	1.1	2.5	2.2	1.9	1.8
Exposure to tobacco smoke at home	1.6	1.8	4.2	-1.5	-0.9	-1.3	-1.5	-0.9	-1.5	-2.1	-0.6	-1.2	-1.4	-1.4
Diastolic blood pressure, automated reading	1.6	4.9	7.2	-2.7	-2.5	-2.4	-2.0	-2.1	-1.8	-2.6	-1.8	-1.8	-2.3	-2.0
Systolic Blood Pressure	1.5	7.7	9.5	-3.1	-3.0	-3.0	-2.6	-3.0	-2.3	-3.0	-2.4	-2.4	-2.9	-2.6
Number of treatments/medications taken	1.5	2.7	3.1	-1.6	-1.8	-1.6	-1.7	-1.6	-1.7	-1.5	-1.6	-1.4	-1.7	-1.7
Length of working week for main job	1.5	1.6	2.9	1.6	1.7	1.4	1.4	0.7	1.1	0.7	1.5	1.5	0.9	1.1
Age at first live birth	1.5	2.6	4.5	1.8	2.1	2.0	1.6	1.8	1.2	1.4	1.1	1.6	1.4	1.5
Ovarian Cancer	1.4	1.8	2.8	-1.3	-1.6	-1.5	-1.3	-1.5	-1.1	-1.1	-1.7	-1.2	-0.9	-1.1
Illnesses of mother	1.4	1.8	3.1	1.8	1.6	1.4	1.4	1.0	1.0	1.7	0.9	1.5	0.8	1.3
Glaucoma (self-reported)	1.4	1.6	2.2	1.5	1.5	1.4	1.4	1.2	1.1	0.8	1.4	1.3	1.0	1.2
Financial situation satisfaction	1.4	1.8	3.4	1.1	1.5	1.7	1.2	1.6	0.8	1.6	0.9	1.8	1.1	1.0
Blood White Count	1.3	9.9	13.0	-3.2	-3.1	-3.3	-3.3	-3.6	-3.4	-2.3	-2.7	-2.5	-3.6	-3.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.9	1.6	1.5	1.1	1.3	0.6	0.8	1.7	0.7	1.5	1.1	1.1
Breast cancer (self-reported)	1.2	1.5	2.9	0.8	0.8	1.2	1.3	1.7	1.4	1.3	1.3	1.0	1.0	1.3
Impedance of whole body	1.2	5.9	10.0	-2.4	-2.2	-2.6	-2.4	-2.0	-2.2	-2.1	-2.6	-3.2	-2.4	-2.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.9	-1.1	-1.6	-0.9	-1.2	-1.0	-1.2	-0.4	-1.7	-1.3	-1.3	-1.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.0	1.3	1.4	1.4	1.2	1.3	1.0	1.0	0.9	1.0	1.2	0.9
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.1	-0.9	-1.5	-1.3	-1.0	-1.8	-0.9	-0.8	-1.5	-1.6	-0.8	-1.0
Breastfed as a baby	1.1	1.3	2.6	1.1	1.5	1.6	1.1	1.6	0.6	1.1	0.7	1.1	0.9	0.9
Hair/balding pattern: Pattern 4	1.1	2.6	3.8	1.7	2.0	1.7	1.6	2.0	1.5	1.3	1.5	0.9	1.8	1.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.7	1.6	1.2	1.5	1.4	1.6	1.3	1.9	0.9	1.0	1.2	1.3
Neck or shoulder pain in last month	1.1	1.6	2.8	-1.5	-1.7	-1.4	-1.3	-1.4	-1.2	-0.3	-1.6	-0.9	-0.8	-1.2
Medication: Ibuprofen	1.1	1.3	2.4	1.0	1.1	1.2	1.1	1.2	1.0	1.6	0.8	1.2	1.2	1.2
Heart disease (mother)	1.1	1.3	2.2	-1.1	-1.2	-1.2	-1.2	-0.8	-1.1	-1.3	-0.9	-1.5	-1.1	-1.2
Long-standing illness, disability or infirmity	1.1	1.7	3.3	-1.3	-1.3	-1.6	-1.2	-1.5	-1.1	-1.8	-0.8	-0.8	-1.3	-1.2
Average weekly beer plus cider intake	1.1	1.5	3.2	-0.9	-1.1	-1.1	-1.2	-1.3	-1.4	-0.6	-1.8	-1.2	-1.3	-1.3
Crohns Disease (2017)	1.0	2.1	3.7	-1.5	-0.7	-1.2	-1.6	-0.6	-1.8	-1.3	-1.6	-1.4	-1.9	-1.9
HDL Cholesterol	1.0	1.7	2.7	1.4	0.9	1.4	1.3	1.6	1.6	0.9	1.1	0.8	1.3	1.5
Lung FVC	1.0	5.0	8.6	2.4	2.4	2.5	2.1	2.9	2.1	2.0	2.1	1.8	2.0	2.1
Relative age of first facial hair	1.0	2.1	3.8	1.6	1.2	1.1	1.5	0.3	1.4	1.2	1.4	1.9	1.8	1.6
Medication: Co-codamol	1.0	1.1	1.7	-1.1	-1.2	-1.2	-1.0	-1.1	-0.8	-0.8	-1.3	-1.1	-1.0	-0.9
Impedance of leg (left)	1.0	4.9	7.4	-2.3	-2.0	-2.3	-2.3	-1.7	-2.1	-1.7	-2.3	-2.7	-2.4	-2.2
Neuroticism score	1.0	2.0	3.3	-1.4	-1.3	-1.3	-1.6	-1.1	-1.7	-1.0	-1.8	-0.8	-1.6	-1.6
Birth weight of first child	1.0	1.9	2.7	1.2	1.3	1.5	1.4	1.6	1.6	0.4	1.4	1.0	1.6	1.6
Chest pain or discomfort	1.0	1.4	2.3	-1.5	-1.2	-1.1	-1.3	-1.0	-1.4	-0.7	-1.0	-1.0	-1.5	-1.2
Family relationship satisfaction	1.0	1.2	2.3	1.1	0.8	1.3	1.1	1.0	1.0	1.5	0.8	1.2	0.9	1.1
Schizophrenia vs Biploar Disorder	0.9	1.2	2.7	-1.4	-1.1	-1.1	-1.1	-0.3	-0.4	-1.6	-0.8	-1.6	-0.9	-0.7
Coronary Artery Disease (CAD)	0.9	1.1	1.9	-1.1	-0.9	-0.9	-0.9	-1.0	-1.1	-1.4	-1.1	-0.6	-1.3	-1.0
HbA1C	0.9	1.0	2.6	0.9	1.3	-0.2	0.4	1.6	0.9	1.0	0.8	0.7	1.1	1.2
Sensitivity / hurt feelings	0.9	1.5	2.1	-1.3	-1.0	-1.2	-1.4	-0.9	-1.4	-1.0	-1.4	-0.6	-1.4	-1.4
Townsend deprivation index at recruitment	0.9	1.2	2.0	-1.3	-0.9	-0.8	-1.3	-0.8	-1.3	-1.0	-1.4	-0.8	-1.1	-1.3
Trunk predicted mass	0.9	5.0	7.4	2.3	2.1	2.4	2.2	1.9	2.0	2.1	2.1	2.7	2.5	2.2
Health satisfaction	0.9	1.2	1.8	-1.3	-1.3	-1.2	-1.1	-1.1	-1.0	-0.6	-1.1	-0.8	-1.1	-1.1
Eye problems/disorders: Glaucoma	0.9	1.1	1.5	1.2	1.2	1.1	1.2	0.8	1.0	0.6	1.1	1.2	0.8	1.1
Myopia	0.9	1.3	3.5	1.4	1.2	1.1	1.1	0.1	0.6	1.9	0.8	1.6	0.8	1.0
Irritable Bowel Disease (IBD)	0.8	1.8	3.3	-1.3	-0.7	-1.2	-1.5	-1.1	-1.8	-0.6	-1.4	-1.0	-1.8	-1.7
Bipolar Disorder (2011)	0.8	0.7	1.8	0.7	0.8	1.0	0.8	1.3	0.8	0.8	0.6	0.7	1.0	0.7
Crohns Disease (2012)	0.8	1.3	2.1	-1.0	-0.6	-0.9	-1.3	-0.5	-1.4	-0.8	-1.4	-1.1	-1.4	-1.4
Hypothyroidism (self reported)	0.8	1.9	3.7	-1.0	-1.9	-1.6	-1.1	-1.8	-0.7	-0.9	-1.5	-1.9	-0.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.0	-1.5	-1.7	-1.5	-1.0	-1.3	-0.8	-0.9	-1.6	-0.9	-0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	-0.9	-1.4	-1.3	-0.9	-1.3	-0.8	-0.4	-1.1	-0.8	-1.0	-0.8
Supplements: Zinc	0.8	0.8	2.6	-1.0	-0.8	-0.7	-0.8	-0.5	-0.5	-1.6	-0.9	-1.2	-0.9	-0.6
Medication: Ramipril	0.8	1.0	2.2	-1.3	-1.0	-0.8	-1.0	-0.9	-1.0	-1.5	-0.8	-0.9	-0.8	-0.9
Trunk fat-free mass	0.8	4.8	7.1	2.2	2.0	2.4	2.1	1.9	2.0	2.1	2.0	2.7	2.4	2.2
Medication: Lansoprazole	0.8	1.0	1.7	-1.3	-0.7	-0.9	-1.1	-0.5	-1.0	-1.3	-0.4	-1.0	-1.1	-1.0
Forced vital capacity (FVC), Best measure	0.8	2.8	4.5	1.9	2.0	2.1	1.5	2.1	1.3	1.1	1.5	1.5	1.4	1.5
Eye problems/disorders: Cataract	0.8	0.9	1.3	0.8	1.1	1.0	0.9	1.1	0.9	0.7	0.5	0.9	1.1	0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	-1.2	-1.4	-0.9	-0.9	-0.9	-0.7	-0.8	-1.0	-0.5	-0.9	-0.6
Impedance of leg (right)	0.7	3.6	6.0	-2.0	-1.6	-1.9	-1.9	-1.3	-1.8	-1.7	-2.0	-2.5	-2.1	-1.8
Multivitamins +/- minerals	0.7	0.8	2.0	1.1	0.9	1.0	0.9	0.8	0.9	0.4	1.4	0.5	0.8	0.9
Impedance of arm (right)	0.7	3.1	5.9	-1.4	-1.7	-2.0	-1.6	-1.8	-1.5	-1.4	-2.0	-2.4	-1.7	-1.6
Pulse wave Arterial Stiffness index	0.7	0.9	2.0	1.1	0.9	0.7	1.0	0.4	0.7	1.4	1.2	0.9	0.9	0.9
Exposure to tobacco smoke outside home	0.7	1.0	2.7	-0.7	-0.2	-0.7	-1.1	-1.0	-1.7	-0.3	-0.8	-0.1	-1.4	-1.3
Medication: Blood pressure	0.7	1.2	1.9	-1.2	-1.0	-1.2	-1.1	-1.3	-1.0	-1.4	-0.7	-0.8	-0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	1.0	0.8	0.9	1.0	1.2	1.1	0.4	0.6	0.3	1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	-1.1	-1.0	-1.1	-1.0	-0.9	-0.8	-1.6	-0.6	-1.3	-1.0	-0.9
Medication: Gliclazide	0.7	0.8	2.1	-1.2	-1.1	-0.9	-0.8	-0.2	-0.5	-1.4	-0.7	-1.0	-0.5	-0.6
Whole body water mass	0.7	4.1	6.9	2.0	1.7	2.2	1.9	1.6	1.7	2.1	1.9	2.6	2.2	1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	-1.1	-0.6	-0.7	-1.0	-0.7	-1.1	-1.3	-0.8	-0.4	-1.2	-1.1
Medication: Bendroflumethiazide	0.7	1.1	2.7	-1.3	-1.2	-1.3	-0.9	-1.2	-0.6	-1.6	-0.6	-0.7	-0.8	-0.8
Illnesses of father: High blood pressure	0.7	0.8	2.2	-0.9	-1.5	-1.0	-0.9	-1.0	-0.5	-0.8	-1.2	-0.5	-0.5	-0.7
Arm fat-free mass (left)	0.7	3.3	7.2	1.7	1.5	1.9	1.7	1.4	1.5	1.9	1.7	2.7	2.0	1.7
Number of operations (self-reported)	0.7	1.1	2.1	-0.6	-0.6	-1.1	-0.9	-1.2	-1.0	-1.4	-0.6	-1.2	-1.4	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	1.2	-1.1	-0.9	-1.0	-1.0	-0.9	-1.1	-0.7	-0.8	-0.5	-1.0	-1.0
Ulcerative Colitis	0.6	0.9	1.6	-1.1	-0.9	-1.0	-1.1	-1.3	-1.1	-0.3	-1.0	-0.4	-0.9	-0.9
Blood Red Count	0.6	5.6	7.7	-2.8	-2.7	-2.3	-2.4	-1.9	-2.1	-2.6	-2.4	-2.2	-2.1	-2.3
Vitamin and mineral supplements	0.6	0.9	2.0	-1.0	-1.4	-1.2	-0.7	-1.2	-0.5	-0.1	-1.3	-0.6	-0.5	-0.7
Pack years adult smoking proportion	0.6	0.9	3.6	0.6	1.1	0.9	0.8	1.1	0.7	0.1	1.9	0.9	0.5	0.7
Medication: Cholesterol lowering	0.6	0.9	1.8	-1.1	-0.5	-0.9	-1.0	-0.8	-1.1	-1.4	-0.8	-0.5	-1.1	-1.1
Impedance of arm (left)	0.6	2.9	5.5	-1.4	-1.5	-1.8	-1.6	-1.5	-1.6	-1.5	-1.8	-2.3	-1.7	-1.6
Pulse wave peak to peak time	0.6	0.7	1.5	-0.9	-0.8	-0.6	-0.8	-0.3	-0.6	-1.2	-1.1	-0.9	-0.8	-0.8
Emphysema/chronic bronchitis	0.6	0.6	1.3	0.7	0.7	0.7	0.9	0.6	0.8	0.4	1.0	1.1	0.8	0.8
Arm predicted mass (right)	0.6	3.0	5.5	1.5	1.4	1.9	1.6	1.6	1.5	1.8	1.7	2.4	1.9	1.6
Whole body fat-free mass	0.6	3.4	6.0	1.9	1.6	2.0	1.8	1.4	1.6	1.9	1.8	2.4	2.0	1.8
Ever had bowel cancer screening	0.6	0.7	2.3	0.8	1.1	1.0	0.7	0.7	0.4	0.7	1.5	0.8	0.5	0.6
Medication: Paracetamol	0.6	1.0	2.1	1.0	0.6	0.9	0.8	0.7	0.8	1.4	1.2	1.3	0.8	1.0
Basal metabolic rate	0.6	3.5	6.8	1.9	1.6	1.9	1.7	1.3	1.5	2.1	1.9	2.6	2.0	1.7
Irritability	0.6	1.0	2.1	0.8	0.8	1.3	0.9	1.2	0.6	0.8	0.8	1.5	1.0	0.7
Supplements: Calcium	0.6	0.7	2.9	0.4	1.0	0.9	0.3	1.7	0.3	0.6	1.3	0.3	-0.1	0.3
Alcohol drinker status: Previous	0.6	0.7	1.7	0.9	0.9	0.8	0.8	0.3	0.3	1.3	0.5	1.0	0.9	0.6
Arm predicted mass (left)	0.6	2.8	6.4	1.6	1.4	1.8	1.6	1.3	1.4	1.8	1.5	2.5	1.8	1.5
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.5	0.6	0.6	1.1	1.0	1.8	1.3	1.1	1.9	1.0	1.4	1.2
Body Mass Index (BMI) (2010)	0.5	0.7	2.3	1.0	0.8	0.6	0.9	-0.1	0.5	1.1	0.6	1.5	0.7	0.7
Triglycerides	0.5	0.9	1.7	-0.8	-0.6	-1.0	-1.0	-1.0	-1.3	-0.3	-1.0	-0.3	-1.2	-1.2
Fed-up feelings	0.5	1.0	2.4	-1.2	-1.0	-0.9	-1.0	-0.5	-0.8	-1.2	-1.5	-0.8	-0.7	-0.9
Sitting height	0.5	3.8	5.6	2.4	1.9	2.2	1.9	2.1	1.9	2.2	1.1	1.1	2.2	2.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.7	0.6	0.6	0.8	0.5	0.9	1.0	0.8	1.1	0.7	0.8
Diabetes (self-reported)	0.5	0.7	1.9	-0.9	-1.4	-1.1	-0.7	-1.2	-0.7	-0.4	-0.9	-0.7	-0.1	-0.6
Fluid intelligence score	0.5	1.1	1.8	-1.2	-1.4	-1.1	-1.1	-0.8	-0.9	-0.8	-0.8	-1.3	-1.1	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	1.3	-1.0	-1.1	-0.9	-0.8	-1.0	-0.6	-0.6	-1.0	-0.5	-0.7	-0.6
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	-0.5	-0.7	-0.9	-0.8	-1.1	-1.0	0.1	-1.1	-0.6	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.5	1.3	1.5	1.7	1.1	1.9	1.0	0.7	1.1	1.2	1.0	1.1
Birth weight	0.5	1.1	2.1	1.4	1.4	0.9	1.1	0.4	0.8	1.2	1.3	0.6	0.9	0.9
Arm fat-free mass (right)	0.5	2.6	4.8	1.4	1.4	1.8	1.4	1.6	1.3	1.6	1.6	2.2	1.8	1.5
Alcohol intake frequency.	0.5	1.1	1.5	-1.2	-1.1	-1.2	-1.1	-1.2	-1.0	-0.9	-0.7	-0.7	-1.0	-0.9
Overall health rating	0.5	1.0	1.9	-1.0	-0.9	-1.0	-1.1	-1.3	-1.4	0.2	-0.7	-0.5	-1.1	-1.2
Smoking status: Previous	0.5	0.7	1.6	-0.7	-1.2	-1.0	-0.8	-1.1	-0.8	-0.1	-1.3	-0.5	-0.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.9	0.3	0.2	0.7	-1.0	0.3	1.1	0.7	1.3	0.6	0.6
Neuroticism (Nagel 2018)	0.4	1.0	2.1	-0.9	-0.9	-0.8	-1.2	-0.8	-1.5	-0.3	-1.1	-0.1	-1.1	-1.3
Age at First Birth	0.4	0.5	2.3	-0.6	-0.4	-0.4	-0.5	-0.1	-0.6	-1.5	-1.0	-0.9	-0.5	-0.5
Fasting Glucose	0.4	0.4	1.2	-0.3	-0.8	-0.5	-0.9	-0.8	-0.7	0.3	-1.1	-0.6	-0.5	-0.5
Lupus	0.4	0.6	0.9	0.8	0.8	0.9	0.9	0.8	0.9	1.0	0.1	0.7	0.7	0.9
Neuroticism	0.4	0.9	1.9	-0.7	-0.7	-0.7	-1.1	-0.7	-1.4	-0.5	-1.3	-0.2	-1.1	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	0.4	0.4	0.7	0.7	0.5	0.7	-0.5	0.9	0.7	0.8	0.7
Medication: Metformin	0.4	0.6	2.0	-0.9	-1.1	-0.8	-0.7	-0.5	-0.5	-0.3	-1.4	-0.3	0.1	-0.5
Leg fat-free mass (left)	0.4	2.3	4.8	1.6	1.2	1.5	1.4	0.9	1.2	1.7	1.6	2.2	1.6	1.3
Stomach or abdominal pain in last month	0.4	0.5	1.7	-0.4	-1.1	-0.9	-0.6	-1.3	-0.5	0.3	-0.4	-0.4	-0.6	-0.6
Medication: Atenolol	0.4	0.5	1.3	-1.1	-0.7	-0.8	-0.6	-0.7	-0.4	-1.0	-0.1	-0.5	-0.8	-0.4
Leg predicted mass (left)	0.4	2.1	4.5	1.5	1.2	1.5	1.3	0.9	1.2	1.6	1.6	2.1	1.6	1.3
Hip circumference	0.4	1.9	4.0	1.4	0.9	1.2	1.3	0.9	1.1	1.9	1.5	2.0	1.4	1.2
Worrier / anxious feelings	0.4	0.8	1.2	-1.0	-1.1	-1.1	-0.9	-0.8	-0.8	-1.1	-0.8	-0.3	-0.9	-0.9
Pulse wave reflection index	0.4	0.4	0.8	0.7	0.6	0.4	0.6	0.8	0.9	0.2	0.8	0.2	0.8	0.7
Blood clot in the leg (DVT)	0.4	0.6	1.4	0.9	0.4	0.3	0.8	-0.7	0.4	1.0	0.7	1.2	0.7	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	-0.5	-1.3	-1.1	-0.7	-1.2	-0.4	-0.5	-1.0	-1.1	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.6	-0.8	-1.0	-0.5	-1.2	-0.3	-0.6	-0.8	-0.8	-0.3	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.6	-0.3	-0.7	-0.7	-0.5	-0.7	-0.7	-0.2	-0.7	-0.9	-0.9
Had major operations	0.4	0.4	1.2	1.0	1.1	0.5	0.7	-0.1	0.3	0.5	0.6	0.8	0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	-0.2	-0.5	-0.8	-0.6	-1.2	-0.9	0.2	-0.3	-0.6	-0.7	-0.8
Illnesses of father: Heart disease	0.4	0.6	1.5	-0.5	-0.3	-0.5	-0.8	-0.5	-0.9	-0.9	-0.7	-0.7	-1.2	-0.9
Friendships satisfaction	0.4	0.5	1.5	0.6	0.8	1.0	0.5	1.2	0.4	1.0	0.5	0.5	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	1.2	0.8	0.9	1.0	0.8	1.2	0.5	0.8	0.8	0.8	1.0
Mother’s age at death	0.4	0.5	2.9	0.6	0.3	0.6	0.6	0.3	0.5	1.7	0.0	0.6	0.8	0.7
Medication: Atorvastatin	0.4	0.4	1.2	-1.1	-0.5	-0.6	-0.7	-0.2	-0.5	-1.0	-0.4	-0.6	-0.6	-0.6
Pain experienced in last month	0.4	0.6	1.4	1.0	1.2	0.8	0.9	1.0	1.0	0.1	0.6	0.0	0.5	0.8
Pack years of smoking	0.4	0.6	2.9	0.3	0.8	0.7	0.5	0.9	0.4	-0.0	1.7	0.7	0.3	0.5
Ulcerative Colitis (UC)	0.3	0.5	0.7	-0.7	-0.6	-0.7	-0.8	-0.8	-0.8	0.1	-0.7	-0.3	-0.8	-0.7
Mean Putamen Volume	0.3	0.4	1.1	0.3	0.2	0.6	0.4	1.1	0.7	0.9	0.4	0.5	0.6	0.6
Neuroticism (2016)	0.3	0.4	0.8	-0.4	-0.9	-0.6	-0.6	-0.6	-0.8	-0.2	-0.8	-0.5	-0.6	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	-0.5	-0.7	-0.7	-0.4	-0.7	-0.7	-0.5	-0.5	-0.4	-0.3	-0.6
Diabetes (father)	0.3	0.4	1.6	-0.7	-0.8	-0.6	-0.3	-0.1	0.3	-1.3	-0.5	-0.9	0.1	0.1
Trunk fat percentage	0.3	1.3	2.3	-1.1	-1.4	-1.2	-1.2	-1.5	-1.5	0.1	-0.8	0.0	-1.1	-1.4
Hand grip strength (right)	0.3	0.8	1.3	-0.9	-0.7	-0.9	-1.0	-0.6	-0.8	-1.1	-0.8	-1.1	-0.7	-0.9
Maternal smoking around birth	0.3	0.5	1.4	0.2	0.4	0.7	0.5	1.2	0.7	0.5	0.7	0.6	1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.6	-0.1	-0.3	-0.7	-0.2	-0.8	-0.4	-1.0	-0.7	-0.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.4	0.5	0.5	0.4	0.8	0.7	-1.0	0.4	0.4	0.5	0.5
Medication: Levothyroxine sodium	0.3	0.5	0.8	-0.6	-0.9	-0.9	-0.8	-0.9	-0.6	-0.1	-0.9	-0.7	-0.7	-0.5
Forced vital capacity (FVC)	0.3	1.1	2.3	1.5	1.2	1.3	0.9	1.2	0.7	1.2	0.8	0.8	0.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.3	1.1	0.7	1.0	1.1	0.4	1.0	0.9	0.2	0.5	1.1	1.0
Weight	0.3	1.7	5.1	1.1	0.8	1.2	1.1	0.6	0.9	1.8	1.5	2.3	1.3	1.0
Depression (self-reported)	0.3	0.4	0.6	-0.5	-0.6	-0.6	-0.6	-0.7	-0.7	-0.4	-0.5	-0.6	-0.7	-0.8
Peak expiratory flow (PEF)	0.3	0.6	1.3	0.9	0.8	0.9	0.8	0.9	0.7	0.5	0.5	1.1	0.5	0.7
Loud music exposure frequency	0.3	0.3	0.9	-0.3	-0.5	-0.2	-0.7	-0.2	-1.0	-0.4	-0.5	-0.0	-1.0	-0.7
Shortness of breath walking on level ground	0.3	0.4	1.1	0.4	0.4	0.5	0.5	0.4	0.5	1.0	-0.4	0.8	1.0	0.7
Mean time to correctly identify matches	0.3	0.5	1.9	0.6	0.7	0.7	0.6	0.2	0.1	1.4	0.3	1.3	0.2	0.3
Leg fat mass (right)	0.3	1.0	3.6	0.7	0.5	0.8	0.7	0.5	0.6	1.4	1.3	1.9	0.8	0.6
Leg pain on walking	0.3	0.3	0.7	-0.7	-0.6	-0.4	-0.6	-0.7	-0.7	-0.1	-0.9	-0.1	-0.4	-0.7
Supplements: Vitamin C	0.3	0.3	1.0	-0.5	0.0	-0.0	-0.6	-0.2	-1.0	-0.2	-0.9	-0.1	-0.8	-0.6
Leg fat-free mass (right)	0.3	1.5	3.5	1.4	0.9	1.2	1.1	0.6	0.9	1.5	1.3	1.9	1.4	1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	0.7	0.2	0.4	0.6	0.2	0.7	1.0	0.4	0.4	0.6	0.6
Diabetes diagnosed by doctor	0.3	0.5	1.6	-0.8	-1.2	-0.8	-0.5	-0.8	-0.5	-0.3	-0.8	-0.5	0.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.4	0.2	0.6	0.6	0.4	0.7	-0.1	0.7	0.7	1.0	0.6
Commuting to job workplace: Walk	0.3	0.3	0.9	0.5	0.5	0.7	0.5	1.0	0.5	0.3	0.3	0.7	0.6	0.5
Back pain experienced in last month	0.3	0.5	1.2	0.6	0.6	0.8	0.5	0.2	0.4	1.0	0.9	1.1	0.6	0.4
Leg predicted mass (right)	0.3	1.7	3.8	1.4	1.0	1.3	1.2	0.6	0.9	1.5	1.4	2.0	1.4	1.1
Guilty feelings	0.3	0.5	1.7	-0.3	0.3	-0.0	-0.7	-0.2	-1.3	0.6	-0.3	0.5	-1.1	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.4	1.0	0.7	0.6	0.6	0.3	0.5	0.4	1.0	0.2	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.6	0.7	0.7	0.6	0.5	0.4	0.4	0.2	1.0	0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.8	-0.3	-0.5	-0.9	-0.1	-0.8	-0.6	-0.3	-0.3	-0.9	-0.8
Reaction Time	0.2	0.5	2.0	0.4	0.6	0.6	0.6	0.1	0.2	1.4	0.1	1.2	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-1.1	-1.3	-0.8	-0.7	-0.6	-0.4	-0.6	-0.3	-0.6	-0.4	-0.4
Blood Platelet Count	0.2	2.6	5.0	1.3	1.3	1.6	1.7	2.2	2.1	1.0	1.6	1.1	1.6	1.7
Height	0.2	4.8	6.3	2.5	2.1	2.4	2.3	2.3	2.2	1.9	1.7	1.7	2.5	2.3
Waist Hip Ratio (WHR)	0.2	0.9	1.8	-1.3	-0.7	-0.9	-0.9	-1.1	-1.2	-0.8	-0.8	-0.5	-1.1	-1.0
Smoking Status	0.2	0.4	1.0	-0.7	-0.2	-0.3	-0.8	-0.2	-1.0	-0.1	-0.4	-0.3	-0.8	-0.9
Chronotype (morning person)	0.2	0.5	1.2	-0.7	-1.1	-1.0	-0.8	-0.7	-0.5	-0.2	-0.2	-0.6	-0.5	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.6	-0.8	-0.4	-0.5	-0.3	-0.3	-0.1	-0.6	-0.5	-0.3	-0.2
Diabetes (mother)	0.2	0.3	0.8	-0.7	-0.9	-0.6	-0.5	-0.6	-0.4	0.1	-0.2	0.0	-0.3	-0.4
Current tobacco smoking	0.2	0.3	1.1	0.2	1.1	0.7	0.3	0.8	-0.1	0.2	0.7	0.4	0.2	0.1
Age when periods started (menarche)	0.2	0.4	0.7	0.6	0.8	0.7	0.5	0.7	0.6	0.8	0.8	0.4	0.5	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.5	0.3	0.1	0.6	-0.4	0.6	-0.0	0.3	0.6	0.2	0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.4	0.8	0.6	0.4	0.3	0.2	0.1	0.7	0.7	-0.0	0.1
Serious illness, injury or assault to yourself	0.2	0.2	1.1	0.2	0.1	-0.2	0.0	-1.1	-0.5	0.6	-0.1	0.8	-0.3	-0.2
Waist circumference	0.2	0.7	3.2	0.6	0.5	0.7	0.6	0.1	0.3	1.4	1.0	1.8	0.6	0.4
Time employed in main current job	0.2	0.2	0.6	0.6	0.8	0.5	0.6	0.5	0.6	-0.1	-0.1	0.2	0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.2	-0.6	-0.4	-0.3	-0.9	-0.5	0.8	-0.8	0.1	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.2	1.1	1.0	1.1	0.7	1.1	0.6	0.7	0.6	0.6	0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	1.1	0.7	0.9	0.7	0.6	0.5	0.7	0.2	0.2	0.5	0.7
Arm fat mass (right)	0.2	0.8	3.8	0.6	0.4	0.6	0.6	0.2	0.4	1.3	1.0	2.0	0.7	0.5
Standing height	0.2	1.6	2.5	1.6	1.3	1.4	1.2	1.2	1.1	1.4	1.0	0.9	1.5	1.3
Medication: Paracetamol	0.2	0.3	0.8	0.7	-0.2	0.1	0.3	-0.1	0.4	0.9	0.7	0.8	0.1	0.5
Number of children fathered	0.2	0.3	1.1	0.4	0.1	0.0	0.5	-0.4	0.3	0.9	0.2	1.1	0.4	0.5
Qualifications: College or University degree	0.2	0.5	1.1	0.9	0.6	0.8	0.7	1.0	0.8	0.1	-0.2	-0.3	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.4	-0.8	-0.5	-0.1	-0.4	0.2	-0.7	-0.6	-0.4	0.1	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.6	-0.4	-0.4	-0.6	-0.2	-0.6	0.1	0.1	-0.7	-0.3	-0.6
Mood swings	0.2	0.3	0.8	-0.5	-0.1	0.0	-0.7	0.2	-0.9	0.1	-0.9	0.2	-0.7	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.8	-0.1	0.1	0.5	-0.5	0.5	0.8	0.3	0.0	0.3	0.5
Hearing aid user	0.2	0.2	0.7	0.5	-0.0	0.2	0.5	0.1	0.8	0.4	0.3	-0.0	0.3	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.0	0.3	0.4	0.4	0.8	0.6	-0.4	0.8	0.3	0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.2	0.0	0.0	-0.5	-0.5	-0.9	-0.5	-0.7	-0.6	-0.7	-0.6
Medication: Lisinopril	0.2	0.2	0.8	-0.5	-0.9	-0.3	-0.4	-0.2	-0.3	-0.4	-0.8	-0.1	-0.2	-0.4
Alcohol drinker status: Never	0.2	0.2	0.6	-0.4	-0.4	-0.3	-0.4	0.3	-0.2	-0.8	0.2	-0.7	-0.4	-0.2
Risk taking	0.2	0.3	0.5	0.5	0.6	0.4	0.5	0.3	0.7	0.3	0.5	0.1	0.6	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.7	-0.6	-0.6	-0.4	-0.8	-0.4	-0.6	-0.1	0.1	-0.5	-0.5
Heart disease (siblings)	0.2	0.3	1.6	-0.6	-0.4	-0.4	-0.4	-0.0	-0.0	-1.3	-0.2	-0.7	-0.5	-0.3
Leg fat mass (left)	0.2	0.6	2.8	0.4	0.3	0.6	0.5	0.2	0.3	1.2	1.0	1.7	0.5	0.3
Depression (Nagel 2018)	0.1	0.1	0.4	-0.4	-0.1	-0.1	-0.5	0.2	-0.4	-0.2	-0.6	-0.3	-0.3	-0.3
Major Depression (MDD)	0.1	0.1	0.4	0.2	0.4	-0.1	-0.2	-0.4	-0.6	-0.5	-0.0	-0.1	-0.6	-0.3
LDL Cholesterol	0.1	0.1	0.4	0.0	-0.6	-0.2	0.0	-0.4	0.1	0.3	-0.5	0.3	0.3	0.1
Primary Biliary Cirrhosis	0.1	0.1	0.4	-0.1	0.3	-0.2	0.2	-0.3	-0.1	-0.0	0.5	0.6	-0.0	0.1
Blood Eosinophil Count	0.1	1.0	2.9	-0.6	-0.9	-1.0	-0.8	-1.7	-1.1	1.4	-0.4	-0.3	-1.1	-0.9
BMI	0.1	0.5	3.0	0.2	0.2	0.4	0.3	-0.3	-0.1	1.2	0.5	1.7	0.2	-0.1
Hair Pigment	0.1	3.4	5.3	1.7	2.1	1.9	1.9	1.5	1.9	1.4	2.3	1.6	2.0	1.8
Tanning	0.1	1.3	2.1	1.3	0.8	0.8	1.2	0.4	1.2	1.3	1.2	1.4	1.2	1.2
Hand grip strength (left)	0.1	0.3	0.7	-0.4	-0.3	-0.4	-0.7	-0.5	-0.8	-0.4	-0.5	-0.7	-0.6	-0.8
Average weekly spirits intake	0.1	0.1	0.6	-0.3	-0.3	-0.2	0.0	0.4	0.5	-0.8	-0.2	-0.3	0.4	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.2	-0.1	0.1	-0.3	0.0	-0.6	0.4	-0.7	-0.0	-0.4	-0.4
Angina	0.1	0.1	0.5	-0.3	0.3	-0.0	0.0	0.3	0.4	-0.7	0.3	0.3	-0.1	0.2
Severe depression (siblings)	0.1	0.1	0.3	-0.0	-0.1	0.0	0.2	0.5	0.6	0.4	-0.1	0.3	0.6	0.3
Average weekly fortified wine intake	0.1	0.1	0.4	0.1	0.1	-0.1	0.1	0.0	0.3	-0.5	0.1	-0.6	0.2	0.2
Relative age voice broke	0.1	0.2	1.1	-0.1	-0.7	-0.7	-0.3	-1.0	-0.2	0.3	-0.2	-0.3	0.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.5	-0.3	-0.6	0.2	-0.3	0.4	-0.3	0.7	-0.2	-0.3	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.5	-0.2	-0.3	-0.1	-0.0	-0.5	-0.0	-0.4	-0.7	-0.5	0.0	-0.1
Supplements: Glucosamine	0.1	0.1	0.4	0.3	-0.1	0.2	0.0	-0.1	0.1	-0.0	0.7	-0.3	-0.2	0.1
Body mass index (BMI)	0.1	0.6	3.4	0.3	0.2	0.5	0.5	0.1	0.3	1.1	1.1	1.8	0.5	0.3
Trunk fat mass	0.1	0.3	0.9	-0.2	-0.4	-0.2	-0.2	-0.6	-0.5	0.9	0.1	1.0	-0.1	-0.4
Past tobacco smoking	0.1	0.2	0.5	0.1	0.3	0.3	0.5	0.6	0.7	-0.4	0.7	0.1	0.3	0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.7	-0.2	0.4	0.6	0.3	0.8	0.3	-0.2	0.5	0.2	0.0	0.3
Had menopause	0.1	0.2	0.6	0.6	0.0	0.3	0.3	-0.3	0.1	0.8	0.1	0.8	0.2	0.3
Mouth/teeth dental problems	0.1	0.2	0.4	0.7	0.5	0.4	0.4	-0.1	0.2	0.4	-0.2	0.6	0.1	0.4
Heart attack	0.1	0.1	0.3	-0.4	-0.0	-0.2	-0.5	0.1	-0.4	-0.3	0.0	0.0	-0.5	-0.4
Pain all over the body in last month	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.4	-0.4	-0.5	0.1	0.1	-0.2	-0.4	-0.3
Arm fat percentage (right)	0.1	0.3	1.4	-0.1	-0.4	-0.2	-0.1	-0.6	-0.4	0.7	0.2	1.2	-0.2	-0.4
Pulse rate	0.1	0.1	0.3	-0.5	-0.5	-0.1	-0.1	-0.1	-0.4	0.1	-0.4	0.3	0.2	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.8	-0.9	-0.6	-0.4	-0.4	0.1	-0.2	-0.2	0.1	-0.6	0.1	-0.4
Headache pain in last month	0.1	0.2	0.3	0.5	0.3	0.6	0.5	0.5	0.5	0.4	0.0	0.3	0.3	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.3	0.2	0.1	0.0	-0.3	-0.5	0.7	-0.0	0.5	-0.0	-0.3
Body fat percentage	0.1	0.5	0.9	-0.6	-0.9	-0.6	-0.6	-0.9	-0.9	0.5	-0.2	0.6	-0.6	-0.9
Leg fat percentage (right)	0.1	0.2	1.0	-0.2	-0.3	-0.1	-0.1	-0.2	-0.1	0.7	0.6	1.0	-0.1	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.6	0.1	-0.1	-0.0	-0.3	-0.3	-0.5	0.7	0.2	-0.0	-0.5	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.1	0.7	0.3	0.8	0.6	0.2	0.5	-0.0	-0.1	0.2	-0.1	0.1	0.1
Angina (self-reported)	0.1	0.1	0.6	-0.4	0.3	-0.1	-0.1	0.2	0.3	-0.8	0.3	0.3	-0.3	0.1
Migraine (self-reported)	0.1	0.2	0.3	0.6	0.5	0.5	0.3	0.4	0.3	0.4	-0.0	0.4	0.4	0.2
Whole body fat mass	0.1	0.3	1.7	0.1	-0.1	0.2	0.1	-0.2	-0.1	1.1	0.6	1.3	0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.7	0.1	0.1	0.1	0.5	0.2	0.8	-0.1	0.4	0.2	0.4	0.6
Medication: Aspirin	0.1	0.2	0.5	-0.7	-0.6	-0.5	-0.3	-0.1	0.1	-0.7	-0.3	-0.2	-0.2	-0.2
Knee pain experienced in last month	0.1	0.2	0.6	-0.7	-0.7	-0.1	-0.2	0.8	0.2	-0.5	-0.2	-0.4	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.7	0.3	0.0	0.1	-0.3	-0.6	-0.8	0.8	-0.5	0.6	-0.3	-0.5
Arm fat percentage (left)	0.1	0.2	1.0	-0.2	-0.4	-0.2	-0.2	-0.5	-0.4	0.6	0.3	1.0	-0.3	-0.4
Qualifications: nursing, teaching	0.1	0.1	0.5	-0.1	-0.1	-0.0	-0.2	0.3	-0.1	0.7	-0.7	-0.6	0.2	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.3	0.0	-0.0	0.2	-0.2	0.2	0.6	0.1	0.2	0.0	0.1
Mineral and other dietary supplements	0.1	0.2	0.5	0.1	-0.1	-0.1	0.5	0.3	0.7	0.5	0.4	0.6	0.6	0.5
Osteoporosis (self-reported)	0.1	0.2	0.7	0.2	0.4	0.3	0.3	0.2	0.2	0.9	0.0	0.6	0.1	0.3
Medication: Aspirin	0.1	0.1	0.3	-0.6	-0.4	-0.3	-0.2	0.1	0.1	-0.6	-0.2	-0.1	-0.1	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.2	1.0	0.0	0.7	0.3	-0.0	0.4	-0.4	1.0	0.4	0.1	-0.1	-0.1
Smoking status: Current	0.1	0.1	0.6	-0.1	0.8	0.3	-0.1	0.3	-0.4	0.1	0.4	0.2	-0.2	-0.2
Arm fat mass (left)	0.1	0.5	2.7	0.4	0.1	0.4	0.4	0.1	0.2	1.1	0.8	1.7	0.5	0.2
Miserableness	0.1	0.2	0.4	0.3	0.6	0.5	0.3	0.6	0.1	0.5	-0.7	0.4	0.1	0.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.1	-0.2	-0.3	-0.4	-0.3	-0.4	0.2	-0.3	-0.4	0.0	-0.4
Ever smoked	0.1	0.2	0.9	-0.2	0.3	-0.0	-0.5	-0.3	-0.9	0.1	-0.5	-0.3	-0.5	-0.6
Leg fat percentage (left)	0.1	0.2	0.6	-0.4	-0.5	-0.3	-0.2	-0.4	-0.3	0.7	0.3	0.8	-0.3	-0.4
Ever depressed for a whole week	0.1	0.1	0.2	0.3	-0.0	0.2	0.3	0.1	0.4	0.4	-0.1	0.2	0.2	0.2
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.1	-0.1	-0.1	-0.2	-0.0	-0.3	0.7	0.2	0.2	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.4	0.0	-0.2	-0.2	-0.4	-0.4	0.3	-0.3	0.1	-0.5	-0.2
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.1	0.3	0.3	-0.2	0.4	-0.4	-0.2	-0.5	0.4	-0.3	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.3	0.7	0.8	0.8	0.8	0.6	0.2	0.2	0.8	-0.0	-0.4	0.5	0.3
Lung FEV1/FVC ratio	0.0	0.1	0.5	-0.4	-0.4	-0.3	-0.3	-0.1	-0.0	-0.4	-0.7	-0.5	0.3	-0.2
Number of incorrect matches in round	0.0	0.1	0.2	0.4	0.4	0.1	0.3	-0.3	0.1	0.1	0.4	-0.1	-0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.4	-0.0	-0.1	0.0	-0.2	-0.2	-0.3	0.6	-0.1	0.4	-0.1	-0.1
Happiness	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.0	0.3	0.0	-0.1	-0.3	-0.4	-0.1	0.0
Lung cancer (father)	0.0	0.1	0.4	0.1	-0.0	-0.3	-0.0	-0.2	0.1	0.7	0.1	0.1	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.2	-0.3	-0.2	-0.1	-0.1	-0.0	-0.0	-0.5	-0.3	-0.2	0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.0	-0.3	-0.0	-0.0	0.3	0.2	0.3	0.3	-0.1	0.1	0.1
Pulse rate, automated reading	0.0	0.1	0.3	-0.1	0.0	0.3	0.3	0.4	0.1	0.1	0.0	0.5	0.5	0.2
Comparative height size at age 10	0.0	0.1	0.2	0.4	0.3	0.3	0.3	0.0	0.3	-0.3	0.5	0.2	0.4	0.3
Number of full sisters	0.0	0.0	0.1	-0.3	0.1	-0.0	0.1	0.2	0.1	-0.2	0.1	0.3	0.3	0.1
Average weekly red wine intake	0.0	0.1	0.3	-0.0	0.0	0.3	0.2	0.2	0.0	0.5	0.2	0.3	0.0	0.1
Loneliness, isolation	0.0	0.0	0.3	-0.0	0.0	-0.1	-0.1	-0.2	-0.1	-0.1	-0.6	-0.0	-0.0	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.2	0.1	-0.1	0.0	-0.0	-0.1	-0.0	-0.1	0.0	-0.1	0.5	-0.1

Hub : Genes

CAND1

Models

Trait associations