Hub : Genes

CAPN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1476	0.0566	1.6e-03	0.039	NA	0.019	NA	0.021	4.9e-04	NA	1.1e-02	NA	8.0e-03
2	GTEx	Cells Transformed fibroblasts	0.2140	0.0520	6.9e-08	0.197	NA	0.155	NA	0.179	1.0e-14	NA	1.1e-11	NA	2.1e-13
3	GTEx	Esophagus Mucosa	0.1140	0.0510	3.5e-03	0.089	NA	0.069	NA	0.090	1.5e-06	NA	2.3e-05	NA	1.4e-06
4	GTEx	Nerve Tibial	0.0985	0.0463	7.5e-03	0.035	NA	0.015	NA	0.003	1.5e-03	NA	2.7e-02	NA	2.0e-01
5	GTEx	Whole Blood	0.1420	0.0520	4.6e-04	-0.003	NA	0.009	NA	-0.001	7.6e-01	NA	4.9e-02	NA	4.3e-01
6	METSIM	Adipose	0.1124	0.0417	3.4e-04	0.015	0.030	0.046	0.043	0.014	2.0e-03	2.1e-05	1.9e-07	4.7e-07	2.6e-03
7	NTR	Blood	0.0437	0.0156	2.5e-04	0.019	0.008	0.016	0.014	0.022	6.3e-07	8.3e-04	4.9e-06	1.9e-05	1.0e-07
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0359	0.0204	3.9e-03	0.019	0.020	0.030	NA	0.018	2.6e-03	2.1e-03	2.2e-04	NA	3.2e-03
9	TCGA	Brain Lower Grade Glioma	0.1302	0.0614	2.4e-03	0.042	0.026	0.019	NA	0.036	1.2e-05	6.0e-04	2.8e-03	NA	6.0e-05
10	TCGA	Thyroid Carcinoma	0.1830	0.0720	2.0e-03	0.006	0.012	0.035	NA	-0.002	7.4e-02	2.1e-02	2.1e-04	NA	6.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	1.7	0.7	0.9	1.1	0.8	-0.7	0.3	1.2	0.7	0.7	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.6	9.2	1.4	1.4	1.4	1.7	-3.0	0.9	0.4	-0.1	1.8	-1.8
Depressed Affect (Nagel 2018)	1.5	3.3	8.8	-1.9	-1.8	-1.4	2.6	1.1	1.1	3.0	-2.0	1.1	0.7
Depression (Nagel 2018)	0.8	1.2	3.4	-0.5	-0.6	-0.4	1.2	-0.5	1.7	1.4	-1.8	0.3	-1.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.3	-1.7	-1.8	-1.9	-0.8	1.5	2.1	0.5	-1.2	0.2	1.7
Neuroticism (Nagel 2018)	1.5	3.6	8.3	-2.9	-2.6	-2.5	1.1	1.6	0.1	2.1	-1.8	1.1	1.4
Schizophrenia (2018)	1.1	2.3	11.4	1.2	1.1	1.0	1.5	-3.4	0.7	-0.5	-0.7	1.7	-1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	0.8	1.0	0.8	-0.6	-0.4	-1.5	-1.3	0.3	-0.8	-0.4
Worry (Nagel 2018)	0.9	2.0	5.1	-2.3	-1.9	-1.8	0.2	1.6	-0.7	0.7	-1.2	0.7	1.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	0.7	0.7	0.8	1.3	-0.0	1.3	0.0	-0.6	1.1	0.7
Alzheimer’s Disease (in father)	0.8	0.8	2.2	-1.2	-1.4	-1.5	-0.2	0.2	0.2	-0.0	-1.4	0.1	0.7
Alzheimer’s Disease (including proxy)	0.4	0.5	2.0	-0.5	-0.3	-0.2	0.9	0.4	1.4	0.2	-0.8	0.5	1.0
Crohns Disease (2017)	0.1	0.3	1.4	-0.4	-0.4	-0.4	-0.4	-0.6	0.8	-0.1	0.0	-1.2	-0.5
Irritable Bowel Disease (IBD)	0.2	0.6	2.3	0.5	0.5	0.4	0.1	-1.5	0.9	-0.5	-0.5	-0.6	-1.1
Ulcerative Colitis (UC)	0.4	0.7	2.3	0.8	0.8	0.7	0.6	-1.5	0.5	-0.4	-0.9	0.4	-0.9
Major Depression (MDD)	1.9	2.3	13.9	0.4	0.5	0.6	0.8	-2.5	0.1	0.4	-3.7	-0.6	-0.7
Reaction Time	1.1	2.1	9.7	0.9	1.1	1.2	1.6	-1.6	3.1	1.1	0.0	0.1	1.1
Verbal and Numeric Reasoning (VNR)	1.2	2.8	7.6	-2.1	-2.3	-2.4	-1.6	2.8	1.3	0.3	-0.0	-0.8	0.6
Breast Cancer	1.7	4.2	10.0	2.8	3.0	3.2	-0.5	0.5	-1.7	-1.4	2.1	-0.2	-2.3
Ovarian Cancer	0.6	0.8	2.6	-1.0	-1.0	-1.0	-0.2	-0.7	1.6	0.7	-0.8	-0.3	0.5
Prostate Cancer	0.9	1.3	3.1	1.7	1.8	1.6	0.8	0.2	-0.4	-0.7	1.4	0.7	0.6
Age at First Birth	0.6	0.9	2.8	0.6	1.3	1.7	-0.3	1.5	1.0	0.5	-0.4	-0.1	0.3
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.7	0.3	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	3.5	-0.3	-0.5	-0.1	-0.1	0.8	-0.7	1.9	1.5	-1.3	-1.8
Coronary Artery Disease (CAD)	0.6	0.7	2.0	-0.5	-0.7	-0.7	1.4	-0.2	0.2	1.4	0.5	1.2	0.2
Crohns Disease (2012)	0.4	0.6	2.0	-0.4	-0.2	-0.2	-0.4	1.0	0.2	-0.6	1.4	-0.9	-1.2
Mean Putamen Volume	0.6	0.7	2.1	0.1	0.4	0.3	-0.8	1.2	-0.3	-1.4	0.0	-0.6	-1.4
Fasting Glucose	1.1	1.4	6.4	-1.0	-1.0	-0.5	1.5	1.2	0.1	2.5	-0.1	-1.1	-0.3
HbA1C	0.4	0.4	1.6	-0.7	-0.5	-0.1	-0.3	0.7	0.2	1.3	-0.3	-1.1	0.2
HDL Cholesterol	0.3	0.6	3.2	0.4	-0.1	-0.4	-0.8	-1.8	-0.2	0.1	-0.0	-1.1	-0.4
LDL Cholesterol	0.4	0.6	2.4	0.1	0.5	0.5	-0.2	-0.9	-0.2	-0.1	0.7	-1.3	-1.6
Lupus	0.6	1.0	2.6	0.8	1.1	1.4	0.9	-0.7	0.3	1.1	0.7	1.6	-0.2
Neuroticism (2016)	0.2	0.3	1.1	0.3	-0.8	-0.9	1.0	-0.3	-0.1	0.1	-0.2	-0.5	0.2
Primary Biliary Cirrhosis	0.5	0.7	2.0	0.9	0.7	0.9	0.7	-0.3	0.6	0.9	1.4	-0.8	-0.2
Rheumatoid Arthritis	1.0	1.4	3.5	-1.4	-1.6	-1.3	0.6	1.9	0.3	1.6	-1.1	0.4	-0.3
Schizophrenia (2014)	1.7	3.7	8.8	2.2	2.6	2.6	1.8	-3.0	0.2	-0.3	0.2	1.8	-1.8
Triglycerides	0.7	1.1	2.7	1.1	1.1	0.9	0.4	-0.7	-1.3	-1.3	0.3	-1.0	-1.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.3	0.5	0.7	0.8	0.2	-1.1	-0.2	-0.0	-0.6	-0.3	-0.7
Ulcerative Colitis	1.9	2.8	7.8	2.3	2.8	2.8	0.9	-1.5	-0.6	-1.0	-0.3	0.3	-1.6
Blood Eosinophil Count	0.9	7.3	26.6	3.8	4.6	5.2	1.4	-1.9	1.5	0.1	1.1	0.3	-1.1
Blood Platelet Count	0.1	1.0	4.5	-0.2	0.4	0.5	-2.1	1.4	-1.0	-1.2	0.7	-0.1	0.3
Blood Red Count	0.2	1.9	5.7	-0.1	1.2	1.6	-2.4	2.4	-1.2	-0.4	1.0	-0.7	-0.6
Blood White Count	0.5	3.6	15.4	0.8	2.1	2.8	0.3	3.9	-0.2	-0.2	2.0	1.7	0.8
Heel T-Score	0.1	0.8	2.5	1.6	1.2	1.1	0.8	-0.6	0.7	-0.3	0.9	0.7	0.2
BMI	0.2	1.0	1.6	1.1	1.2	1.2	-0.7	-1.2	-1.2	-1.0	0.8	-0.0	0.5
Height	0.2	3.5	7.3	-1.4	-2.4	-2.7	1.6	-0.4	2.2	0.7	-2.4	1.6	1.9
Waist Hip Ratio (WHR)	0.4	1.8	4.8	-1.3	-1.0	-0.9	-2.0	-1.3	0.2	0.8	-0.1	-2.2	1.9
Systolic Blood Pressure	0.3	1.4	6.4	-0.1	-0.1	-0.2	-0.1	0.5	0.8	-0.1	2.2	1.3	2.5
Smoking Status	0.4	0.9	3.9	-0.6	-0.6	-0.8	-1.5	0.0	-0.5	-0.0	-0.1	-2.0	-1.2
Allergy or Eczema	0.4	1.2	4.4	0.8	0.8	1.0	-0.3	1.1	-2.1	-1.0	1.1	-0.7	-1.0
Cardiovascular Disease	0.4	1.3	3.8	-1.0	-0.7	-0.5	-0.5	0.8	1.7	1.3	1.9	0.6	1.1
Hypothyroidism (self reported)	0.4	0.9	2.5	-1.2	-1.1	-1.3	-0.8	-0.1	1.6	-0.8	-0.6	-0.1	0.4
Respiratory disease	0.5	1.0	2.1	-1.0	-1.4	-1.4	-0.4	-0.1	0.3	0.8	-0.7	-1.4	-1.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	4.0	-1.0	-0.9	-1.0	-2.0	0.2	0.6	-0.4	0.3	-1.6	0.0
Lung FEV1/FVC ratio	0.2	1.0	2.7	-0.2	0.2	0.0	-1.4	1.2	-1.6	-0.7	1.6	0.1	-1.0
Lung FVC	0.0	0.1	0.3	-0.1	0.0	0.3	0.3	0.0	-0.4	0.5	0.0	0.1	0.3
Neuroticism	0.7	1.6	4.2	-1.6	-1.4	-1.1	0.8	0.9	-0.4	2.0	-2.0	0.1	0.7
Chronotype (morning person)	0.3	0.8	2.1	1.0	1.0	1.1	0.2	0.1	0.3	-1.1	0.8	1.4	-0.6
Hair Pigment	0.1	3.4	11.0	-2.2	-1.8	-1.9	-1.9	1.4	-3.3	-0.1	-2.0	-1.2	0.1
Tanning	0.0	0.5	2.2	-0.5	-0.5	-0.4	-0.2	1.5	-0.2	0.8	0.8	-0.3	0.7
Hand grip strength (left)	0.3	0.8	1.8	-0.0	0.0	-0.1	-1.0	0.3	-1.2	-1.0	1.2	-1.4	-1.1
Number of treatments/medications taken	0.3	0.5	1.4	-0.4	-0.7	-0.7	-0.1	0.0	1.0	-0.3	-1.2	0.3	-1.0
Average weekly spirits intake	1.1	1.3	3.5	0.1	0.7	0.6	-1.2	-1.5	-1.0	-1.6	-1.9	-0.7	-0.8
Sensitivity / hurt feelings	0.6	1.0	3.1	-1.0	-1.0	-1.1	-0.2	1.5	-0.6	-0.7	-0.4	1.0	1.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.6	-0.2	-0.0	0.1	1.2	0.2	1.2	1.1	-1.6	0.8	0.3
Hearing difficulty/problems: Yes	0.4	0.7	1.9	-1.2	-0.7	-0.5	-0.5	1.3	0.3	0.3	-1.4	0.2	-0.8
Relative age of first facial hair	0.4	0.8	2.0	-0.9	-1.0	-1.1	-0.6	1.3	-0.3	-0.5	-1.4	-0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	8.1	2.5	2.6	2.8	1.3	-0.5	-1.7	-0.3	0.2	0.1	-2.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.0	0.3	0.3	0.6	1.9	-0.3	-0.0	0.7	-2.0	1.6	-0.4
Ever had hysterectomy (womb removed)	1.0	1.1	3.6	-1.2	-1.5	-1.4	0.5	0.3	0.6	0.5	-1.9	0.9	0.0
Systolic blood pressure, automated reading	0.9	2.7	5.9	2.3	2.1	1.9	0.3	-0.9	-0.9	-2.4	2.3	0.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-1.6	-1.1	-1.0	-1.2	-0.0	0.1	1.3	-0.6	-1.2	0.3
Angina	1.0	1.3	3.7	-1.4	-1.7	-1.9	-1.8	0.4	-0.2	-0.8	-0.5	-0.3	-0.0
Medication for hormone replacement therapy	1.7	1.9	5.8	-2.0	-2.4	-2.4	-0.8	0.8	-0.9	0.6	-0.3	-0.8	-0.6
Vitamin and mineral supplements	0.5	0.7	2.0	-0.1	0.3	0.4	-0.3	1.4	-1.4	0.4	1.3	-0.1	0.8
Supplements: Zinc	1.4	1.6	6.4	-0.8	-0.7	-0.5	-1.6	0.1	0.2	1.3	0.7	-1.7	-2.5
Medication: Co-codamol	1.9	2.2	6.0	2.2	2.2	2.5	1.7	-0.9	0.8	-0.2	-0.1	-0.4	-1.3
Medication: Metformin	0.2	0.3	1.1	0.1	-0.2	-0.2	-0.6	-0.2	0.7	0.1	0.1	-0.7	1.1
Diabetes (father)	1.1	1.4	4.5	-0.7	-0.5	-0.1	0.9	2.1	1.1	1.8	1.1	1.1	1.0
Diabetes (mother)	0.8	1.1	2.9	1.0	0.8	0.6	-0.9	-0.6	-1.0	-1.7	0.6	-1.4	-1.0
Severe depression (siblings)	0.7	0.7	4.2	-0.7	-0.6	-0.6	-0.8	-0.8	0.6	-0.2	-2.1	0.5	-0.0
Pack years adult smoking proportion	0.6	1.0	3.1	-0.3	-0.0	-0.2	-1.3	0.1	-1.4	-1.1	0.6	-1.1	-1.8
Impedance of leg (right)	0.9	4.5	9.4	-3.1	-2.9	-2.8	-1.2	3.1	1.0	2.0	-0.9	0.1	1.6
Leg fat-free mass (left)	0.1	0.7	1.5	1.2	1.0	0.8	0.2	-1.2	-0.3	-1.2	0.9	0.0	-0.2
Trunk fat percentage	0.1	0.5	1.8	0.0	0.1	0.2	-0.9	-1.3	-0.9	-0.3	-0.4	-1.0	-0.3
Hand grip strength (right)	0.9	2.6	6.6	-0.8	-0.7	-0.8	-2.1	0.7	-2.4	-0.0	1.3	-2.6	-2.3
Townsend deprivation index at recruitment	0.7	1.0	3.2	-0.6	-0.3	-0.2	-1.0	0.2	-0.9	0.3	-1.6	-1.8	-1.5
Current tobacco smoking	0.2	0.4	1.3	-0.8	-0.4	-0.3	-0.7	0.3	0.5	0.1	-1.2	-0.2	-0.9
Average weekly fortified wine intake	0.4	0.4	3.8	-0.2	0.1	0.2	0.3	-1.9	0.3	0.4	-0.4	0.3	0.1
Maternal smoking around birth	0.9	1.4	4.8	0.3	0.7	0.5	-0.7	-1.0	-1.5	-0.9	-1.7	-0.7	-2.2
Fed-up feelings	1.5	2.8	5.6	-2.3	-2.4	-2.2	0.7	1.4	0.8	2.2	-1.8	-0.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-0.2	-0.0	0.2	0.9	-0.1	0.6	0.7	-1.2	-0.1	-1.4
Relative age voice broke	0.4	0.6	1.5	-0.7	-0.9	-0.9	-0.5	1.2	-0.5	0.0	0.7	-0.4	0.9
Taking other prescription medications	0.4	0.6	2.4	0.3	0.4	0.7	1.0	-0.2	-0.4	0.5	-1.6	1.1	-0.5
Age when periods started (menarche)	0.6	1.3	3.6	1.7	1.9	1.8	0.5	-1.3	0.2	-0.8	-0.2	0.9	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	-0.7	-0.7	-0.7	1.0	0.6	0.8	-0.5	-1.0	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	1.8	1.1	0.7	-0.3	-0.9	-0.6	-1.4	1.1	-0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.1	0.2	0.6	0.7	0.5	0.6	0.9	0.5	0.6	0.4	1.4
Qualifications: CSEs or equivalent	1.8	2.3	5.4	-2.3	-2.3	-2.1	0.3	1.3	0.1	2.3	-0.3	-0.2	-0.8
Serious illness, injury or assault to yourself	0.4	0.4	2.1	-0.5	-0.4	-0.1	0.7	0.5	-0.1	0.6	-1.4	-0.0	-0.9
High blood pressure	0.3	0.9	3.1	0.3	0.7	0.8	0.4	-0.4	1.0	0.2	1.7	1.8	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.9	0.5	0.3	0.5	0.3	1.0	-1.4	-0.3	1.0	-0.3	-1.2
Multivitamins +/- minerals	0.2	0.3	1.2	0.0	-0.6	-0.5	-0.2	-0.2	0.4	0.4	-0.4	-0.6	-1.1
Stomach or abdominal pain in last month	0.6	0.7	2.9	0.9	1.0	0.9	1.0	-0.4	1.7	0.2	-0.3	0.5	-0.5
Supplements: Glucosamine	0.4	0.6	2.4	1.0	0.7	0.8	0.7	-0.6	0.5	-0.2	-0.1	-0.5	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.3	-1.1	-1.5	-1.5	0.1	-0.4	0.1	0.6	-1.2	0.4	-0.1
Medication: Atenolol	0.4	0.5	2.2	0.1	-0.1	0.1	0.7	1.5	0.4	0.6	0.9	0.8	0.9
Medication: Levothyroxine sodium	0.4	0.8	1.7	1.1	1.1	0.9	-0.1	-1.2	-0.1	-1.3	-0.0	-1.0	-0.6
Sitting height	0.1	0.6	2.6	-0.1	-0.5	-0.7	0.5	1.0	0.1	0.4	1.6	0.8	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.4	0.1	0.1	0.2	-0.9	0.1	-0.3	-0.4	-0.7	-1.5	-1.5
High blood pressure (mother)	0.8	1.1	3.0	-1.2	-1.5	-1.6	-0.4	0.9	-0.1	0.2	1.7	0.3	0.9
Body mass index (BMI)	0.6	2.5	4.6	2.0	2.1	2.1	-0.6	-2.0	-1.5	-1.8	0.5	-1.2	-0.8
Impedance of leg (left)	1.3	6.3	14.1	-3.8	-3.7	-3.5	-1.6	3.3	1.1	2.6	-0.6	-0.4	1.2
Leg predicted mass (left)	0.1	0.7	1.5	1.2	1.0	0.8	0.2	-1.2	-0.3	-1.2	0.9	0.0	-0.2
Trunk fat mass	0.1	0.5	2.1	0.4	0.5	0.4	-0.7	-1.4	-0.7	-0.6	-0.2	-0.8	-0.3
Waist circumference	0.3	1.1	3.1	0.7	1.1	1.1	-1.2	-1.8	-0.6	-1.2	-0.1	-1.2	0.2
Number of incorrect matches in round	0.5	0.8	3.5	0.4	0.7	1.0	1.0	-0.8	1.9	0.5	-1.0	0.1	0.1
Past tobacco smoking	0.9	1.7	7.3	0.3	0.5	0.7	1.6	1.4	0.3	-0.0	1.5	2.7	1.4
Alcohol usually taken with meals	0.2	0.3	1.9	0.2	0.2	0.2	0.4	0.1	-0.2	0.6	0.4	1.4	-0.3
Nervous feelings	1.7	3.2	10.5	-1.3	-1.3	-1.2	1.1	2.8	-0.6	0.6	1.1	2.5	3.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	-0.8	-0.7	-0.7	-0.5	0.4	0.6	0.5	-0.5	-0.7	0.6
Hearing difficulty/problems with background noise	0.4	0.7	3.7	-0.4	-0.2	-0.1	1.0	-0.6	-0.3	0.6	-1.9	1.1	0.2
Hair/balding pattern: Pattern 2	0.8	1.0	2.6	-0.4	-1.0	-1.4	-0.1	-0.9	1.2	-1.6	-1.2	0.3	0.2
Had menopause	0.7	0.8	3.5	1.1	1.1	0.9	0.6	-0.6	-0.2	-1.9	-0.9	0.4	-0.2
Had other major operations	0.4	0.5	1.1	-0.6	-0.6	-0.3	0.4	0.9	-0.9	0.9	1.0	0.0	-0.7
Forced vital capacity (FVC)	0.1	0.4	1.2	-0.6	-1.0	-1.1	0.2	0.5	-0.2	0.5	0.0	0.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.2	2.0	1.4	1.0	-0.5	-0.9	-0.9	-1.8	1.1	-1.4	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.5	0.4	0.3	0.5	0.4	1.2	0.8	-0.1	-0.1	1.1	-0.3
Qualifications: None of the above	0.5	1.0	3.3	1.0	0.9	1.0	0.9	-0.7	0.3	-0.2	-1.6	0.1	-1.8
Financial difficulties in last 2 years	0.2	0.3	0.6	0.7	0.3	0.5	0.8	-0.3	0.8	0.5	0.2	0.1	-0.3
Mouth/teeth dental problems	0.4	0.6	2.5	-0.4	-0.2	-0.2	-0.1	-1.6	1.0	0.6	0.2	0.9	0.9
Heart attack	0.5	0.7	1.5	-1.0	-1.2	-1.2	-0.3	-0.5	-0.8	0.6	-0.6	0.4	-1.1
Allergy	0.3	0.6	2.7	-0.2	-0.0	-0.3	-0.4	-0.1	1.6	-0.1	0.4	0.8	1.6
Pain all over the body in last month	0.8	0.9	2.2	-0.4	0.0	0.3	-1.3	0.7	-0.5	0.2	1.4	-1.4	-1.5
Diabetes (self-reported)	0.9	1.5	5.5	-1.5	-1.1	-1.2	-2.4	0.8	0.6	0.0	0.2	-1.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	0.1	0.3	0.3	-0.4	1.1	-0.3	-0.6	0.7	-0.9	-0.6
Medication: Ramipril	1.1	1.4	3.3	-1.8	-1.7	-1.6	-0.2	-0.5	1.1	1.2	-0.7	0.7	0.9
Medication: Simvastatin	0.4	0.5	1.5	0.1	0.3	0.4	1.2	0.1	0.4	0.7	-1.2	1.2	0.3
Fluid intelligence score	1.8	3.7	9.8	-2.7	-2.6	-2.6	-1.4	3.1	1.3	0.9	-0.2	-0.6	0.8
Illnesses of siblings	1.6	2.2	4.5	-1.7	-1.9	-1.6	0.7	0.6	0.3	1.6	-1.4	1.8	2.1
Neuroticism score	0.9	1.9	5.2	-1.7	-1.6	-1.6	0.6	1.0	0.5	1.1	-2.3	0.7	1.4
Weight	0.2	0.8	1.7	1.2	1.1	1.0	-0.2	-1.3	-0.5	-1.3	0.5	-0.3	-0.1
Impedance of arm (right)	0.7	3.1	6.4	-2.5	-2.5	-2.5	0.5	1.4	1.2	2.4	-1.2	0.8	1.0
Arm fat percentage (right)	0.2	1.0	2.8	1.0	1.2	1.2	-0.4	-1.7	-1.2	-0.9	-0.1	-0.5	-0.4
Trunk fat-free mass	0.2	0.9	2.4	1.5	1.3	1.1	0.7	-0.7	0.8	-1.2	0.9	0.5	0.0
Hip circumference	0.2	0.8	2.0	1.2	1.4	1.4	0.0	-0.9	-0.6	-1.2	0.3	-0.3	-0.6
Time employed in main current job	0.4	0.5	2.1	-0.5	-0.7	-0.6	0.3	-0.1	1.1	1.4	-0.4	-0.6	-0.1
Alcohol intake versus 10 years previously	0.4	0.6	1.8	0.4	0.5	0.6	-0.1	-0.2	1.3	0.2	-0.1	-1.3	-1.1
Father’s age at death	1.2	1.6	8.6	-0.0	-0.1	-0.1	0.5	-1.2	2.9	0.6	-1.3	0.5	1.9
Worrier / anxious feelings	0.5	0.9	3.0	-0.3	-0.6	-0.6	1.4	-0.1	0.7	0.4	-1.7	1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	6.2	0.7	0.6	0.9	2.5	-0.3	0.7	1.9	-0.8	0.8	-0.9
Falls in the last year	0.4	0.5	1.6	0.4	0.2	0.5	1.2	0.4	-0.5	1.3	-0.3	0.9	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	4.4	-0.6	-0.7	-0.6	-0.8	0.9	-0.7	0.7	0.8	-0.6	2.1
Number of live births	0.3	0.5	0.8	0.8	0.8	0.7	-0.1	0.6	0.5	-0.9	0.9	0.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.7	-1.1	-1.3	-1.3	-0.7	1.2	-0.9	0.6	0.8	-0.4	0.0
Pulse rate	0.3	0.5	1.5	0.8	1.1	1.2	-0.2	-0.7	-0.0	-0.0	1.1	-0.3	-0.0
Happiness	2.2	2.7	6.7	-2.0	-1.7	-1.6	0.7	-0.5	2.3	2.6	-1.6	0.4	1.5
Noisy workplace	0.7	0.8	2.0	-0.9	-1.0	-0.8	-0.9	0.4	0.9	1.1	-0.5	-1.4	0.8
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	-0.1	-0.1	-0.1	0.1	-0.5	0.0	0.4	-0.6	0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.0	-0.4	-0.4	-0.3	-1.4	0.9	-0.1	-0.5	0.5	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	3.8	1.2	1.3	1.1	-0.2	0.4	-0.1	-1.9	-1.2	-0.2	-0.7
Asthma	0.9	1.8	3.3	-1.4	-1.6	-1.6	-1.1	-0.9	-0.3	0.6	-1.8	-1.7	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	6.8	0.3	0.1	-0.1	-1.1	-0.8	0.2	-0.7	1.5	-1.2	-2.6
Medication: Cholesterol lowering	0.3	0.5	2.2	-0.7	-0.8	-0.8	0.3	-0.6	0.2	0.9	-1.5	0.4	-0.1
Depression (self-reported)	0.4	0.5	1.1	0.8	0.6	0.6	0.8	0.6	-0.1	0.7	0.7	1.0	-0.4
Medication: Lansoprazole	0.7	0.8	2.5	-0.5	-0.9	-1.1	-0.9	0.7	-1.6	-0.7	0.7	-1.1	-0.3
Prospective memory result	0.6	0.7	2.0	0.9	0.7	0.7	-0.7	0.8	0.3	-0.4	1.4	-0.9	-1.0
Lung cancer (father)	0.8	1.0	1.7	0.5	0.2	0.4	1.3	-1.1	1.2	1.0	-1.3	1.3	0.4
Illnesses of mother	0.6	0.7	2.8	0.3	0.4	0.6	1.3	0.4	0.3	0.7	-1.1	0.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	-0.5	-0.9	-1.0	-0.2	0.9	-1.1	0.5	0.9	-0.0	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	-0.1	0.2	0.2	0.3	0.4	0.0	-0.4	-0.5	1.0	-0.1
Impedance of arm (left)	0.6	2.6	7.0	-2.5	-2.6	-2.6	-0.1	0.6	0.3	1.7	-1.4	0.3	0.6
Arm fat mass (right)	0.3	1.1	2.5	1.1	1.2	1.2	-0.6	-1.6	-1.4	-1.3	0.4	-0.8	-0.4
Trunk predicted mass	0.2	1.0	2.6	1.6	1.4	1.2	0.8	-0.8	0.8	-1.1	0.9	0.6	0.0
Standing height	0.2	2.0	3.8	-1.4	-1.8	-1.9	0.8	1.3	1.9	0.9	0.2	1.6	1.4
Length of working week for main job	0.2	0.3	1.5	-0.5	0.1	0.4	-0.3	0.4	0.3	1.2	-0.0	-0.1	0.6
Exposure to tobacco smoke at home	0.5	0.6	1.8	0.4	0.8	0.8	0.0	-1.0	-1.3	0.2	0.0	-0.8	-1.1
Breastfed as a baby	0.8	1.0	4.3	-0.4	-0.2	0.0	0.8	0.4	2.1	0.8	-1.3	1.3	1.1
Tense / ‘highly strung’	1.0	1.7	4.1	-1.6	-1.6	-1.6	0.8	0.2	0.5	0.9	-2.0	1.6	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.6	-0.6	-0.7	-0.4	1.5	1.8	0.4	1.8	0.1	2.1	0.7
Hair/balding pattern: Pattern 4	0.4	0.9	3.6	-0.2	-0.3	-0.3	-1.0	-0.3	0.1	0.5	1.7	-0.7	-1.9
Birth weight of first child	0.9	1.6	4.6	-1.4	-1.7	-1.3	1.1	-0.3	0.3	2.1	-1.5	0.7	0.7
Peak expiratory flow (PEF)	1.2	2.9	6.7	-1.3	-1.1	-1.1	-2.4	2.0	-2.6	0.6	1.6	-1.9	-1.3
Pulse wave reflection index	1.4	1.7	4.6	-2.1	-1.9	-1.9	-0.2	1.3	1.1	0.9	-0.6	0.6	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.6	-0.7	-0.7	0.4	-0.0	0.0	0.5	-0.4	-0.6	-0.2
Loud music exposure frequency	0.8	0.8	5.6	-0.5	-0.4	-0.2	0.7	0.5	-0.6	2.4	1.0	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	-0.9	-1.0	-1.0	-0.7	0.6	0.1	-0.1	0.7	-0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.1	-0.5	-0.8	-0.6	0.5	0.4	0.3	1.7	0.3	-1.1	0.2
Blood clot in the leg (DVT)	1.6	2.1	4.0	1.7	1.8	1.9	2.0	-1.0	0.5	-1.0	-0.8	1.9	0.7
Medication: Paracetamol	0.3	0.6	2.0	-0.7	-0.4	-0.6	-0.1	-0.2	-1.2	-1.4	-0.4	-0.0	-0.9
Headache pain in last month	0.4	0.7	2.9	-0.2	-0.2	-0.1	1.4	0.7	0.4	0.5	-1.0	1.7	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.7	-0.2	-0.1	-0.2	-0.7	0.9	-1.4	-0.7	1.3	-1.6	-0.3
Glaucoma (self-reported)	0.3	0.4	2.0	0.2	-0.0	-0.1	0.1	0.4	1.4	-0.4	-0.4	0.6	1.0
Gout (self-reported)	0.5	0.7	3.0	0.2	0.3	0.6	1.2	-0.2	-0.1	1.7	-0.2	0.9	1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.2	0.3	0.2	0.0	-0.1	-0.7	0.8	-1.1	0.1	-0.9	-0.1
Medication: Amlodipine	0.4	0.6	3.3	0.8	0.6	0.7	0.8	0.0	1.8	0.5	-0.3	0.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	-0.4	-1.2	-1.3	-0.7	-0.1	-0.8	-1.1	-0.9	-0.6	-0.2
Birth weight	0.5	1.1	4.2	-0.6	-0.9	-0.8	0.9	0.2	1.3	0.0	-0.9	2.0	1.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	4.2	0.1	-0.0	-0.2	-0.2	-2.0	-0.1	-0.2	-2.0	0.2	-0.3
High blood pressure (siblings)	0.8	1.1	2.5	1.1	1.6	1.4	-0.3	-0.9	-0.7	-1.6	1.1	-0.5	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.3	-0.8	-0.9	0.3	0.5	-0.4	0.2	0.3	0.5	0.9
Body fat percentage	0.1	0.6	1.6	0.1	0.3	0.3	-1.3	-1.2	-1.1	-0.7	-0.4	-0.9	-0.1
Leg fat percentage (right)	0.2	0.7	1.5	0.5	0.8	0.8	-1.2	-1.0	-0.8	-1.0	-0.6	-0.6	0.3
Arm fat-free mass (right)	0.1	0.5	1.1	1.0	0.9	0.8	-0.0	-0.6	0.0	-1.0	0.9	0.0	-0.2
Exposure to tobacco smoke outside home	1.6	2.2	7.5	1.7	1.7	1.5	0.1	-2.7	-1.5	-1.7	-0.7	0.2	-0.3
Comparative body size at age 10	1.3	3.5	11.2	2.7	2.6	2.4	0.2	-1.8	-1.0	-3.3	0.2	-0.3	-0.4
Number of full brothers	0.6	0.8	2.6	-0.8	-0.7	-0.6	-0.8	1.0	-0.7	0.7	0.2	-1.6	-1.0
Worry too long after embarrassment	1.4	2.4	7.1	-2.2	-2.5	-2.7	-0.7	0.8	0.1	0.3	-1.5	0.9	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.8	-0.1	0.2	0.6	1.6	2.2	1.6	1.7	0.2	1.8	0.5
Wheeze or whistling in the chest in last year	0.5	0.9	6.2	-0.4	-0.7	-0.8	-0.4	-0.8	0.6	-0.6	-2.5	-0.3	-0.3
Number of children fathered	0.9	1.0	4.8	-0.1	-0.1	-0.4	-0.6	0.8	-0.9	-0.7	2.2	-1.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.0	-0.8	-1.4	-1.6	-0.7	-1.1	-0.1	-0.1	-1.4	-2.0	-0.2
Age at first live birth	0.5	0.8	4.1	-0.9	-0.6	-0.3	0.9	0.9	0.5	2.0	-0.2	1.0	-0.4
Pulse wave peak to peak time	0.1	0.2	0.8	0.0	-0.3	-0.3	-0.3	-0.2	-0.1	0.4	0.5	-0.9	-0.1
Health satisfaction	0.3	0.4	2.8	0.0	0.2	0.3	0.3	0.6	1.7	0.1	-0.4	0.0	-0.3
Shortness of breath walking on level ground	2.4	2.9	7.5	1.9	2.1	2.2	2.7	-1.0	0.6	-0.7	-1.0	2.4	-0.1
Qualifications: College or University degree	0.2	0.7	3.0	-0.9	-0.7	-0.8	-1.0	0.2	-0.7	-0.3	0.5	0.4	1.7
Eye problems/disorders: None of the above	0.4	0.4	1.5	0.6	0.5	0.4	-0.9	-0.2	0.3	-0.6	0.7	-1.2	-0.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.1	-1.9	-2.0	-1.8	-0.7	0.2	0.1	1.7	-1.3	-0.8	0.8
Emphysema/chronic bronchitis	0.6	0.6	1.6	-0.5	-0.5	-0.3	1.0	0.2	-0.3	1.3	-0.9	-0.7	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.6	2.7	0.2	0.2	0.4	0.5	0.9	0.5	1.1	0.2	-0.2	1.6
Neck or shoulder pain in last month	0.7	1.0	2.8	-0.7	-0.5	-0.2	0.6	1.7	1.6	1.0	-0.4	0.5	-1.5
Medication: Blood pressure	0.4	0.7	2.5	-0.1	-0.0	0.1	0.6	-0.5	1.6	0.7	-0.8	1.5	0.4
Angina (self-reported)	0.8	1.1	3.0	-1.3	-1.5	-1.7	-1.7	0.6	-0.2	-0.8	-0.4	-0.1	-0.0
Migraine (self-reported)	2.3	2.9	8.1	2.8	2.5	2.3	0.4	-0.8	-1.1	-1.8	1.4	-0.9	-0.8
Medication: Ibuprofen	0.6	0.8	2.2	-0.3	-0.6	-0.7	-1.1	-0.2	0.3	-0.5	1.1	-1.3	-1.5
Medication: Allopurinol	0.6	0.8	2.8	-0.3	-0.2	0.1	0.7	0.4	0.4	1.7	-0.9	1.0	1.6
Medication: Omeprazole	1.3	1.5	5.2	-1.8	-2.2	-2.3	-1.1	0.4	-0.1	0.5	-0.1	0.1	0.3
Medication: Seretide 50 evohaler	1.7	2.0	10.3	-0.3	-0.4	-0.5	-1.6	-0.5	-1.2	-0.1	-0.1	-2.2	-3.2
Mean time to correctly identify matches	1.1	2.1	5.9	1.4	1.4	1.5	2.0	-1.8	2.4	0.3	-0.4	0.5	1.1
Heart disease (mother)	0.4	0.4	1.1	0.3	0.8	0.9	-0.2	0.5	-1.0	0.4	0.3	0.3	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.8	5.5	-1.7	-1.9	-2.0	-0.6	0.3	-1.3	0.2	-2.4	-0.1	-0.5
Whole body fat mass	0.1	0.6	1.8	0.4	0.5	0.5	-0.9	-1.3	-1.0	-0.8	-0.1	-0.8	-0.3
Leg fat mass (right)	0.2	1.0	2.1	0.9	1.1	1.0	-1.1	-1.3	-1.1	-1.4	-0.1	-0.6	-0.1
Arm predicted mass (right)	0.1	0.6	1.3	1.2	1.0	0.9	-0.1	-0.7	-0.0	-1.0	0.9	-0.1	0.1
Pulse rate, automated reading	0.2	0.6	1.4	-1.1	-0.8	-0.4	-0.6	0.2	-0.3	0.9	-0.7	-1.2	-0.7
Alcohol intake frequency.	0.8	1.8	4.4	2.0	2.0	2.1	1.8	0.5	-0.2	-0.8	0.9	0.9	-0.6
Comparative height size at age 10	0.1	0.3	1.5	-0.1	-0.4	-0.5	0.1	0.7	-0.6	-0.5	1.2	-0.2	0.0
Number of full sisters	0.9	1.1	4.1	0.3	0.1	0.1	-0.2	-0.3	-1.4	0.5	-0.6	-2.0	-2.0
Suffer from ‘nerves’	0.8	1.2	4.7	-1.2	-1.3	-1.2	-0.6	2.2	0.7	1.0	0.4	-0.8	0.3
Overall health rating	0.3	0.6	2.2	0.6	0.2	0.1	1.5	-0.8	0.6	-0.2	-1.2	0.6	-0.7
Chest pain or discomfort	0.3	0.4	1.0	-0.8	-0.5	-0.6	0.3	0.0	0.0	-0.6	-1.0	0.8	0.7
Had major operations	0.4	0.4	1.1	-0.7	-0.6	-0.3	0.0	0.8	0.4	1.0	0.3	-0.7	-1.0
Age at last live birth	1.1	1.6	4.5	-1.7	-1.4	-1.2	0.3	1.9	0.9	2.1	0.3	0.2	0.2
Family relationship satisfaction	0.8	1.0	4.7	-1.0	-0.5	-0.7	-0.6	-0.9	2.2	-0.8	-1.1	0.5	0.1
Leg pain on walking	1.9	2.4	9.5	0.8	1.0	1.3	3.1	1.1	-0.3	0.4	-1.5	2.7	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	1.1	0.7	0.7	0.8	-1.1	-0.1	0.0	0.4	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.6	1.8	1.8	1.4	0.6	-1.7	-0.5	-1.9	-0.1	0.8	-0.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.0	-0.6	-0.6	-0.6	-0.3	-0.1	0.1	1.7	0.7	-0.8	-0.1
Medication: Aspirin	0.6	0.8	1.6	1.1	1.2	1.2	0.5	-1.3	1.0	-0.1	-0.0	0.5	-0.8
Supplements: Vitamin C	1.3	1.5	5.2	0.6	0.6	0.7	2.3	-1.8	1.5	0.4	-1.3	1.3	-0.5
Knee pain experienced in last month	0.6	0.9	2.7	0.6	0.4	0.5	1.6	0.2	-1.0	-0.2	-1.3	0.5	-1.5
Hypertension (Self-reported)	0.3	0.8	4.1	-0.0	0.5	0.6	0.1	-0.1	0.9	0.4	2.0	1.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.1	-1.2	-1.5	-1.4	-0.8	1.2	-0.8	0.4	0.1	-0.7	-0.3
Illnesses of father: Heart disease	0.7	1.0	2.6	-1.3	-1.2	-1.1	0.1	-0.6	-0.5	1.6	-0.8	0.4	1.3
Illnesses of siblings: Diabetes	1.2	1.5	9.9	0.5	0.4	0.4	-0.4	-0.0	-1.0	-0.9	-0.9	-1.3	-3.1
Smoking status: Previous	0.7	1.0	5.4	-0.4	-0.7	-0.8	-0.8	-0.9	-0.0	0.6	-0.8	-2.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.3	-1.7	-2.0	-2.3	-0.4	-0.0	1.3	0.9	0.6	0.2	1.3
Whole body fat-free mass	0.1	0.7	1.6	1.3	1.0	0.9	0.5	-0.7	0.3	-1.1	1.1	0.3	-0.0
Leg fat-free mass (right)	0.1	0.5	1.5	0.9	0.6	0.5	0.1	-1.0	-0.2	-0.8	1.2	-0.3	-0.5
Arm fat percentage (left)	0.3	1.4	4.1	1.0	1.1	1.1	-0.8	-2.0	-1.7	-1.1	-0.2	-1.0	-0.6
Average weekly red wine intake	0.4	0.6	2.1	0.3	0.4	0.2	-0.7	-1.4	-0.9	-1.0	-0.8	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.2	0.9	0.7	0.6	-1.0	-0.4	-0.6	-1.3	0.4	-1.5	-0.3
Mood swings	0.7	1.2	5.2	0.0	0.1	0.1	1.8	-0.3	0.2	-0.2	-2.3	1.8	0.5
Loneliness, isolation	0.8	1.1	3.8	-0.9	-0.9	-0.7	0.9	-0.1	1.6	1.5	-1.9	0.1	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	2.4	0.0	0.2	0.4	0.5	0.3	-0.2	0.3	-0.7	0.7	-1.6
Ever had bowel cancer screening	1.2	1.4	5.3	1.2	1.4	1.5	1.1	-0.4	0.2	-0.4	-2.3	1.4	-0.5
Diabetes diagnosed by doctor	0.4	0.6	2.8	-0.6	-0.4	-0.4	-1.7	0.7	0.5	-0.3	0.4	-1.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.1	-0.9	-1.0	-0.8	-0.8	0.3	-0.6	1.5	-0.3	-1.8	-1.5
Friendships satisfaction	2.0	2.5	6.1	-2.1	-1.7	-1.7	0.8	-0.6	2.5	1.2	-1.5	1.8	1.2
Qualifications: nursing, teaching	1.8	2.7	5.8	2.4	2.1	1.9	2.1	-2.2	0.0	-0.7	-0.5	1.8	-0.7
Commuting to job workplace: Walk	0.8	0.8	1.8	-1.0	-1.2	-1.2	-0.6	0.3	0.9	0.6	-0.2	-1.0	-1.3
Eye problems/disorders: Cataract	1.5	1.7	3.5	-0.8	-0.8	-0.6	1.7	0.3	1.5	1.9	-1.6	1.8	1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	4.7	0.5	0.2	0.2	-0.6	0.5	-1.7	-0.6	1.8	-2.2	-1.6
Medication for cholesterol	0.7	1.1	3.4	1.2	1.2	1.1	0.8	-1.3	0.2	-0.7	-1.9	0.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.6	-1.5	-1.6	-1.6	-0.2	1.1	0.9	-0.2	-0.3	0.9	1.5
Back pain experienced in last month	0.6	0.9	3.3	-0.2	-0.6	-0.8	1.0	-0.1	0.5	-0.4	-1.7	0.4	-1.8
Mineral and other dietary supplements	1.0	1.3	4.8	-0.8	-0.3	-0.2	-1.0	1.8	-0.3	-0.2	2.2	-0.2	1.9
Breast cancer (self-reported)	2.0	2.4	5.7	-1.9	-2.2	-2.4	-1.1	1.4	1.1	0.0	-0.4	0.4	2.1
Asthma (self-reported)	1.0	2.1	4.2	-1.7	-1.9	-1.8	-1.1	-0.8	0.2	1.0	-2.1	-1.6	-1.1
Osteoporosis (self-reported)	0.9	1.2	2.9	-0.6	-0.9	-0.7	0.3	-0.7	1.6	1.2	-1.4	0.9	1.7
Osteoarthritis (self-reported)	1.9	2.4	5.2	2.0	1.9	2.1	2.3	0.2	-1.0	-0.7	0.7	1.4	-1.7
Medication: Aspirin	0.4	0.6	1.1	1.0	0.9	0.9	0.2	-0.9	0.9	-0.5	-0.1	0.3	-1.0
Medication: Gliclazide	0.2	0.3	1.2	-0.0	-0.1	-0.2	-0.8	0.0	0.3	0.1	0.7	-1.1	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	0.2	-0.0	-0.1	0.2	-0.6	1.1	-0.6	-0.9	0.6	-0.8
Smoking status: Current	0.2	0.4	1.0	-0.9	-0.5	-0.4	-0.7	0.4	0.4	0.2	-1.0	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.9	1.3	1.2	1.2	-0.1	-0.5	-2.0	-1.8	0.3	0.8	-0.3
Whole body water mass	0.2	0.9	2.1	1.5	1.3	1.1	0.5	-0.8	0.2	-1.1	1.1	0.3	-0.1
Leg predicted mass (right)	0.1	0.5	1.4	0.9	0.7	0.5	0.2	-1.1	-0.2	-0.8	1.2	-0.2	-0.5
Arm fat mass (left)	0.3	1.0	3.0	0.8	1.0	0.9	-0.8	-1.7	-1.3	-1.1	0.2	-0.9	-0.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	1.0	0.9	1.1	1.2	0.3	0.3	-0.5	-0.2	1.4	-0.6
Average weekly champagne plus white wine intake	0.6	0.8	2.8	0.2	-0.0	-0.3	-1.3	0.5	-0.1	-1.2	1.4	-0.0	1.7
Miserableness	0.4	0.7	1.9	-0.9	-0.7	-0.6	1.2	0.2	-0.3	1.4	-1.1	0.5	0.4
Guilty feelings	0.6	0.8	3.2	-0.9	-0.8	-0.8	0.1	0.3	0.7	0.2	-1.8	0.7	1.3
Wears glasses or contact lenses	0.6	0.7	3.0	-0.6	-0.7	-0.5	0.4	0.8	0.2	0.4	-0.6	1.2	1.7
Ever taken oral contraceptive pill	1.2	1.3	2.9	-1.7	-1.6	-1.6	-1.7	0.9	-0.1	0.4	-0.9	-0.7	-0.2
Hearing aid user	2.4	2.8	7.1	-2.1	-2.4	-2.0	-0.9	1.7	0.5	2.7	-0.4	-1.4	0.2
Mother’s age at death	0.5	0.6	1.9	0.9	1.0	0.8	0.3	-0.0	-1.0	-1.4	0.5	0.8	0.2
Financial situation satisfaction	1.7	2.2	6.1	-1.6	-1.5	-1.4	0.8	-0.5	2.5	1.7	-2.0	0.6	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	0.8	0.6	0.9	0.8	0.3	0.3	1.0	0.3	-0.6	-0.3
Commuting to job workplace: Public transport	0.8	0.9	6.4	-0.5	-0.6	-0.4	0.3	-0.6	0.9	0.6	-2.5	-0.1	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	0.5	0.4	0.5	-0.0	0.3	0.9	-0.5	0.6	0.7	1.2
Medication: Blood pressure	0.2	0.4	1.9	-0.2	0.4	0.3	-0.7	-0.5	-0.3	-0.8	1.4	0.1	0.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.2	0.3	0.6	1.1	2.0	0.8	-0.5	0.4	-2.3	1.0	-1.0
Supplements: Fish oil (including cod liver oil)	1.5	1.9	9.4	0.6	0.2	0.1	0.1	-1.9	-0.0	0.6	-1.8	-1.4	-3.1
High cholesterol (Self-reported)	0.2	0.4	1.3	0.5	0.6	0.8	0.4	0.1	1.1	0.8	-0.5	0.4	0.4
Medication: Bendroflumethiazide	0.8	1.3	6.6	0.7	1.1	1.0	-0.1	-0.8	-1.2	-0.2	2.6	-0.4	-1.1
Medication: Paracetamol	0.2	0.4	1.3	-0.7	-0.6	-0.8	-0.2	0.1	-0.7	-1.1	-0.6	0.3	-0.4
Medication: Lisinopril	1.2	1.5	7.3	0.6	0.7	0.6	1.2	-1.0	0.8	-1.2	-0.4	2.7	1.5
Medication: Atorvastatin	0.7	0.9	3.5	1.4	1.0	0.9	0.1	-1.9	0.7	-0.0	-0.1	-1.0	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.5	0.3	0.2	-0.3	-0.4	-0.2	0.1	0.8	-0.8	0.5
Alcohol drinker status: Never	2.4	2.8	7.0	2.6	2.5	2.5	1.6	-0.9	-0.6	-1.5	1.1	0.6	-1.2
Ever smoked	1.1	2.0	7.4	-0.1	0.1	-0.1	-1.9	-2.1	-0.3	-0.2	-1.5	-2.7	-1.3
Basal metabolic rate	0.1	0.6	1.4	1.2	1.0	0.8	0.2	-0.9	0.0	-1.1	1.0	0.1	-0.0
Leg fat percentage (left)	0.2	0.6	2.4	0.1	0.4	0.4	-1.6	-0.9	-0.8	-0.6	-0.1	-1.2	-0.1
Arm fat-free mass (left)	0.1	0.6	1.3	1.1	1.1	1.1	0.2	-0.4	0.2	-0.9	1.1	0.1	-0.0
Number of operations (self-reported)	0.8	1.1	2.4	-1.3	-1.4	-1.0	-0.2	1.6	-0.8	1.4	0.5	0.0	-1.1
Average weekly beer plus cider intake	0.4	0.6	2.5	-0.7	-0.7	-0.6	-1.1	0.2	-0.3	0.9	0.3	-1.6	-0.5
Irritability	0.7	1.1	4.2	-1.3	-1.2	-1.5	-0.6	0.3	-0.8	-0.6	-2.0	0.4	0.3
Risk taking	0.9	1.4	6.0	0.3	0.9	1.1	-0.4	-0.9	-1.2	0.1	-0.9	-1.7	-2.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	0.5	0.4	0.3	0.5	-1.0	-0.9	-0.9	-0.1	0.8	0.2
Fractured/broken bones in last 5 years	0.5	0.7	2.9	0.3	0.2	0.0	0.6	-0.3	-0.1	-1.1	-0.2	1.7	1.5
Age started oral contraceptive pill	0.3	0.3	1.4	0.4	-0.0	-0.1	0.3	0.1	-0.8	-0.8	-1.2	0.4	0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.0	0.3	0.3	0.1	-0.5	0.2	-1.3	-1.2	1.4	-0.6	0.0
Ever depressed for a whole week	0.7	0.9	4.8	-0.3	0.1	0.6	0.5	1.3	1.1	2.2	-0.4	-0.0	-0.8
Unable to work because of sickness or disability	0.4	0.6	1.4	0.2	0.2	0.5	0.9	0.6	-0.8	1.2	1.0	0.2	-1.2
Commuting to job workplace: Cycle	1.2	1.5	5.2	-1.6	-1.5	-1.2	-0.5	2.3	0.1	1.1	1.3	0.3	-0.3
Myopia	0.8	1.2	3.0	-1.7	-1.5	-1.4	-1.4	1.1	-0.0	0.8	-0.3	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.9	0.2	-0.1	-0.1	-0.0	0.4	-0.8	-0.2	-1.3	-1.7	-0.4
Cholesterol lowering medication	0.7	1.0	2.5	1.5	1.4	1.6	1.2	0.3	0.9	-0.1	0.2	0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	-1.3	-1.5	-1.4	-0.8	0.0	0.4	1.0	-0.1	0.2	0.5
Pain experienced in last month	1.1	1.8	5.5	0.5	0.5	0.4	-2.1	-0.3	-0.9	-0.3	2.4	-1.5	1.9
Supplements: Calcium	0.6	0.6	3.4	0.3	0.3	0.4	0.3	-0.1	1.8	1.1	0.4	0.2	-1.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.9	0.1	0.2	0.2	-0.6	-0.7	0.8	-0.5	-1.4	-0.5	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	-1.1	-1.2	-1.2	-0.4	-0.3	-0.9	0.7	-0.4	0.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	5.3	2.0	2.1	2.1	2.2	-1.4	0.7	-1.4	-1.1	2.3	0.8
Heart disease (siblings)	0.5	0.7	2.0	1.1	1.4	1.4	0.1	-0.2	-0.0	-1.1	0.3	-0.2	-0.2
Alcohol drinker status: Previous	0.5	0.5	1.4	0.4	0.6	0.9	1.1	-0.3	0.3	1.2	-0.2	0.6	0.8
Pack years of smoking	0.6	0.9	2.5	0.2	0.4	0.2	-1.0	-0.3	-1.6	-1.2	0.6	-1.0	-1.6
Impedance of whole body	1.0	4.9	12.1	-3.4	-3.5	-3.4	-0.6	2.2	0.6	2.4	-1.1	0.1	1.1
Leg fat mass (left)	0.2	0.8	1.8	0.6	0.8	0.7	-1.3	-1.3	-1.1	-1.2	0.0	-0.9	-0.4
Arm predicted mass (left)	0.1	0.5	1.0	1.0	1.0	0.9	0.2	-0.3	0.3	-0.9	0.9	0.3	0.1