Hub : Genes

CAPN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1476 0.0566 1.6e-03 0.039 NA 0.019 NA 0.021 4.9e-04 NA 1.1e-02 NA 8.0e-03
2 GTEx Cells Transformed fibroblasts 0.2140 0.0520 6.9e-08 0.197 NA 0.155 NA 0.179 1.0e-14 NA 1.1e-11 NA 2.1e-13
3 GTEx Esophagus Mucosa 0.1140 0.0510 3.5e-03 0.089 NA 0.069 NA 0.090 1.5e-06 NA 2.3e-05 NA 1.4e-06
4 GTEx Nerve Tibial 0.0985 0.0463 7.5e-03 0.035 NA 0.015 NA 0.003 1.5e-03 NA 2.7e-02 NA 2.0e-01
5 GTEx Whole Blood 0.1420 0.0520 4.6e-04 -0.003 NA 0.009 NA -0.001 7.6e-01 NA 4.9e-02 NA 4.3e-01
6 METSIM Adipose 0.1124 0.0417 3.4e-04 0.015 0.030 0.046 0.043 0.014 2.0e-03 2.1e-05 1.9e-07 4.7e-07 2.6e-03
7 NTR Blood 0.0437 0.0156 2.5e-04 0.019 0.008 0.016 0.014 0.022 6.3e-07 8.3e-04 4.9e-06 1.9e-05 1.0e-07
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0359 0.0204 3.9e-03 0.019 0.020 0.030 NA 0.018 2.6e-03 2.1e-03 2.2e-04 NA 3.2e-03
9 TCGA Brain Lower Grade Glioma 0.1302 0.0614 2.4e-03 0.042 0.026 0.019 NA 0.036 1.2e-05 6.0e-04 2.8e-03 NA 6.0e-05
10 TCGA Thyroid Carcinoma 0.1830 0.0720 2.0e-03 0.006 0.012 0.035 NA -0.002 7.4e-02 2.1e-02 2.1e-04 NA 6.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.5 0.8 1.7 0.7 0.9 1.1 0.8 -0.7 0.3 1.2 0.7 0.7 -1.3
Bipolar Disorder or Schizophrenia 1.0 2.6 9.2 1.4 1.4 1.4 1.7 -3.0 0.9 0.4 -0.1 1.8 -1.8
Depressed Affect (Nagel 2018) 1.5 3.3 8.8 -1.9 -1.8 -1.4 2.6 1.1 1.1 3.0 -2.0 1.1 0.7
Depression (Nagel 2018) 0.8 1.2 3.4 -0.5 -0.6 -0.4 1.2 -0.5 1.7 1.4 -1.8 0.3 -1.0
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.3 -1.7 -1.8 -1.9 -0.8 1.5 2.1 0.5 -1.2 0.2 1.7
Neuroticism (Nagel 2018) 1.5 3.6 8.3 -2.9 -2.6 -2.5 1.1 1.6 0.1 2.1 -1.8 1.1 1.4
Schizophrenia (2018) 1.1 2.3 11.4 1.2 1.1 1.0 1.5 -3.4 0.7 -0.5 -0.7 1.7 -1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 2.3 0.8 1.0 0.8 -0.6 -0.4 -1.5 -1.3 0.3 -0.8 -0.4
Worry (Nagel 2018) 0.9 2.0 5.1 -2.3 -1.9 -1.8 0.2 1.6 -0.7 0.7 -1.2 0.7 1.6
Alzheimer’s Disease (in mother) 0.6 0.7 1.8 0.7 0.7 0.8 1.3 -0.0 1.3 0.0 -0.6 1.1 0.7
Alzheimer’s Disease (in father) 0.8 0.8 2.2 -1.2 -1.4 -1.5 -0.2 0.2 0.2 -0.0 -1.4 0.1 0.7
Alzheimer’s Disease (including proxy) 0.4 0.5 2.0 -0.5 -0.3 -0.2 0.9 0.4 1.4 0.2 -0.8 0.5 1.0
Crohns Disease (2017) 0.1 0.3 1.4 -0.4 -0.4 -0.4 -0.4 -0.6 0.8 -0.1 0.0 -1.2 -0.5
Irritable Bowel Disease (IBD) 0.2 0.6 2.3 0.5 0.5 0.4 0.1 -1.5 0.9 -0.5 -0.5 -0.6 -1.1
Ulcerative Colitis (UC) 0.4 0.7 2.3 0.8 0.8 0.7 0.6 -1.5 0.5 -0.4 -0.9 0.4 -0.9
Major Depression (MDD) 1.9 2.3 13.9 0.4 0.5 0.6 0.8 -2.5 0.1 0.4 -3.7 -0.6 -0.7
Reaction Time 1.1 2.1 9.7 0.9 1.1 1.2 1.6 -1.6 3.1 1.1 0.0 0.1 1.1
Verbal and Numeric Reasoning (VNR) 1.2 2.8 7.6 -2.1 -2.3 -2.4 -1.6 2.8 1.3 0.3 -0.0 -0.8 0.6
Breast Cancer 1.7 4.2 10.0 2.8 3.0 3.2 -0.5 0.5 -1.7 -1.4 2.1 -0.2 -2.3
Ovarian Cancer 0.6 0.8 2.6 -1.0 -1.0 -1.0 -0.2 -0.7 1.6 0.7 -0.8 -0.3 0.5
Prostate Cancer 0.9 1.3 3.1 1.7 1.8 1.6 0.8 0.2 -0.4 -0.7 1.4 0.7 0.6
Age at First Birth 0.6 0.9 2.8 0.6 1.3 1.7 -0.3 1.5 1.0 0.5 -0.4 -0.1 0.3
Bipolar Disorder (2011) 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.7 0.3 -0.7
Body Mass Index (BMI) (2010) 0.9 1.2 3.5 -0.3 -0.5 -0.1 -0.1 0.8 -0.7 1.9 1.5 -1.3 -1.8
Coronary Artery Disease (CAD) 0.6 0.7 2.0 -0.5 -0.7 -0.7 1.4 -0.2 0.2 1.4 0.5 1.2 0.2
Crohns Disease (2012) 0.4 0.6 2.0 -0.4 -0.2 -0.2 -0.4 1.0 0.2 -0.6 1.4 -0.9 -1.2
Mean Putamen Volume 0.6 0.7 2.1 0.1 0.4 0.3 -0.8 1.2 -0.3 -1.4 0.0 -0.6 -1.4
Fasting Glucose 1.1 1.4 6.4 -1.0 -1.0 -0.5 1.5 1.2 0.1 2.5 -0.1 -1.1 -0.3
HbA1C 0.4 0.4 1.6 -0.7 -0.5 -0.1 -0.3 0.7 0.2 1.3 -0.3 -1.1 0.2
HDL Cholesterol 0.3 0.6 3.2 0.4 -0.1 -0.4 -0.8 -1.8 -0.2 0.1 -0.0 -1.1 -0.4
LDL Cholesterol 0.4 0.6 2.4 0.1 0.5 0.5 -0.2 -0.9 -0.2 -0.1 0.7 -1.3 -1.6
Lupus 0.6 1.0 2.6 0.8 1.1 1.4 0.9 -0.7 0.3 1.1 0.7 1.6 -0.2
Neuroticism (2016) 0.2 0.3 1.1 0.3 -0.8 -0.9 1.0 -0.3 -0.1 0.1 -0.2 -0.5 0.2
Primary Biliary Cirrhosis 0.5 0.7 2.0 0.9 0.7 0.9 0.7 -0.3 0.6 0.9 1.4 -0.8 -0.2
Rheumatoid Arthritis 1.0 1.4 3.5 -1.4 -1.6 -1.3 0.6 1.9 0.3 1.6 -1.1 0.4 -0.3
Schizophrenia (2014) 1.7 3.7 8.8 2.2 2.6 2.6 1.8 -3.0 0.2 -0.3 0.2 1.8 -1.8
Triglycerides 0.7 1.1 2.7 1.1 1.1 0.9 0.4 -0.7 -1.3 -1.3 0.3 -1.0 -1.6
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.3 0.5 0.7 0.8 0.2 -1.1 -0.2 -0.0 -0.6 -0.3 -0.7
Ulcerative Colitis 1.9 2.8 7.8 2.3 2.8 2.8 0.9 -1.5 -0.6 -1.0 -0.3 0.3 -1.6
Blood Eosinophil Count 0.9 7.3 26.6 3.8 4.6 5.2 1.4 -1.9 1.5 0.1 1.1 0.3 -1.1
Blood Platelet Count 0.1 1.0 4.5 -0.2 0.4 0.5 -2.1 1.4 -1.0 -1.2 0.7 -0.1 0.3
Blood Red Count 0.2 1.9 5.7 -0.1 1.2 1.6 -2.4 2.4 -1.2 -0.4 1.0 -0.7 -0.6
Blood White Count 0.5 3.6 15.4 0.8 2.1 2.8 0.3 3.9 -0.2 -0.2 2.0 1.7 0.8
Heel T-Score 0.1 0.8 2.5 1.6 1.2 1.1 0.8 -0.6 0.7 -0.3 0.9 0.7 0.2
BMI 0.2 1.0 1.6 1.1 1.2 1.2 -0.7 -1.2 -1.2 -1.0 0.8 -0.0 0.5
Height 0.2 3.5 7.3 -1.4 -2.4 -2.7 1.6 -0.4 2.2 0.7 -2.4 1.6 1.9
Waist Hip Ratio (WHR) 0.4 1.8 4.8 -1.3 -1.0 -0.9 -2.0 -1.3 0.2 0.8 -0.1 -2.2 1.9
Systolic Blood Pressure 0.3 1.4 6.4 -0.1 -0.1 -0.2 -0.1 0.5 0.8 -0.1 2.2 1.3 2.5
Smoking Status 0.4 0.9 3.9 -0.6 -0.6 -0.8 -1.5 0.0 -0.5 -0.0 -0.1 -2.0 -1.2
Allergy or Eczema 0.4 1.2 4.4 0.8 0.8 1.0 -0.3 1.1 -2.1 -1.0 1.1 -0.7 -1.0
Cardiovascular Disease 0.4 1.3 3.8 -1.0 -0.7 -0.5 -0.5 0.8 1.7 1.3 1.9 0.6 1.1
Hypothyroidism (self reported) 0.4 0.9 2.5 -1.2 -1.1 -1.3 -0.8 -0.1 1.6 -0.8 -0.6 -0.1 0.4
Respiratory disease 0.5 1.0 2.1 -1.0 -1.4 -1.4 -0.4 -0.1 0.3 0.8 -0.7 -1.4 -1.3
Type 2 Diabetes (T2D) (2018) 0.5 1.0 4.0 -1.0 -0.9 -1.0 -2.0 0.2 0.6 -0.4 0.3 -1.6 0.0
Lung FEV1/FVC ratio 0.2 1.0 2.7 -0.2 0.2 0.0 -1.4 1.2 -1.6 -0.7 1.6 0.1 -1.0
Lung FVC 0.0 0.1 0.3 -0.1 0.0 0.3 0.3 0.0 -0.4 0.5 0.0 0.1 0.3
Neuroticism 0.7 1.6 4.2 -1.6 -1.4 -1.1 0.8 0.9 -0.4 2.0 -2.0 0.1 0.7
Chronotype (morning person) 0.3 0.8 2.1 1.0 1.0 1.1 0.2 0.1 0.3 -1.1 0.8 1.4 -0.6
Hair Pigment 0.1 3.4 11.0 -2.2 -1.8 -1.9 -1.9 1.4 -3.3 -0.1 -2.0 -1.2 0.1
Tanning 0.0 0.5 2.2 -0.5 -0.5 -0.4 -0.2 1.5 -0.2 0.8 0.8 -0.3 0.7
Hand grip strength (left) 0.3 0.8 1.8 -0.0 0.0 -0.1 -1.0 0.3 -1.2 -1.0 1.2 -1.4 -1.1
Number of treatments/medications taken 0.3 0.5 1.4 -0.4 -0.7 -0.7 -0.1 0.0 1.0 -0.3 -1.2 0.3 -1.0
Average weekly spirits intake 1.1 1.3 3.5 0.1 0.7 0.6 -1.2 -1.5 -1.0 -1.6 -1.9 -0.7 -0.8
Sensitivity / hurt feelings 0.6 1.0 3.1 -1.0 -1.0 -1.1 -0.2 1.5 -0.6 -0.7 -0.4 1.0 1.8
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.6 -0.2 -0.0 0.1 1.2 0.2 1.2 1.1 -1.6 0.8 0.3
Hearing difficulty/problems: Yes 0.4 0.7 1.9 -1.2 -0.7 -0.5 -0.5 1.3 0.3 0.3 -1.4 0.2 -0.8
Relative age of first facial hair 0.4 0.8 2.0 -0.9 -1.0 -1.1 -0.6 1.3 -0.3 -0.5 -1.4 -0.5 -0.0
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 8.1 2.5 2.6 2.8 1.3 -0.5 -1.7 -0.3 0.2 0.1 -2.0
Ever used hormone-replacement therapy (HRT) 0.9 1.1 4.0 0.3 0.3 0.6 1.9 -0.3 -0.0 0.7 -2.0 1.6 -0.4
Ever had hysterectomy (womb removed) 1.0 1.1 3.6 -1.2 -1.5 -1.4 0.5 0.3 0.6 0.5 -1.9 0.9 0.0
Systolic blood pressure, automated reading 0.9 2.7 5.9 2.3 2.1 1.9 0.3 -0.9 -0.9 -2.4 2.3 0.3 0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.4 -1.6 -1.1 -1.0 -1.2 -0.0 0.1 1.3 -0.6 -1.2 0.3
Angina 1.0 1.3 3.7 -1.4 -1.7 -1.9 -1.8 0.4 -0.2 -0.8 -0.5 -0.3 -0.0
Medication for hormone replacement therapy 1.7 1.9 5.8 -2.0 -2.4 -2.4 -0.8 0.8 -0.9 0.6 -0.3 -0.8 -0.6
Vitamin and mineral supplements 0.5 0.7 2.0 -0.1 0.3 0.4 -0.3 1.4 -1.4 0.4 1.3 -0.1 0.8
Supplements: Zinc 1.4 1.6 6.4 -0.8 -0.7 -0.5 -1.6 0.1 0.2 1.3 0.7 -1.7 -2.5
Medication: Co-codamol 1.9 2.2 6.0 2.2 2.2 2.5 1.7 -0.9 0.8 -0.2 -0.1 -0.4 -1.3
Medication: Metformin 0.2 0.3 1.1 0.1 -0.2 -0.2 -0.6 -0.2 0.7 0.1 0.1 -0.7 1.1
Diabetes (father) 1.1 1.4 4.5 -0.7 -0.5 -0.1 0.9 2.1 1.1 1.8 1.1 1.1 1.0
Diabetes (mother) 0.8 1.1 2.9 1.0 0.8 0.6 -0.9 -0.6 -1.0 -1.7 0.6 -1.4 -1.0
Severe depression (siblings) 0.7 0.7 4.2 -0.7 -0.6 -0.6 -0.8 -0.8 0.6 -0.2 -2.1 0.5 -0.0
Pack years adult smoking proportion 0.6 1.0 3.1 -0.3 -0.0 -0.2 -1.3 0.1 -1.4 -1.1 0.6 -1.1 -1.8
Impedance of leg (right) 0.9 4.5 9.4 -3.1 -2.9 -2.8 -1.2 3.1 1.0 2.0 -0.9 0.1 1.6
Leg fat-free mass (left) 0.1 0.7 1.5 1.2 1.0 0.8 0.2 -1.2 -0.3 -1.2 0.9 0.0 -0.2
Trunk fat percentage 0.1 0.5 1.8 0.0 0.1 0.2 -0.9 -1.3 -0.9 -0.3 -0.4 -1.0 -0.3
Hand grip strength (right) 0.9 2.6 6.6 -0.8 -0.7 -0.8 -2.1 0.7 -2.4 -0.0 1.3 -2.6 -2.3
Townsend deprivation index at recruitment 0.7 1.0 3.2 -0.6 -0.3 -0.2 -1.0 0.2 -0.9 0.3 -1.6 -1.8 -1.5
Current tobacco smoking 0.2 0.4 1.3 -0.8 -0.4 -0.3 -0.7 0.3 0.5 0.1 -1.2 -0.2 -0.9
Average weekly fortified wine intake 0.4 0.4 3.8 -0.2 0.1 0.2 0.3 -1.9 0.3 0.4 -0.4 0.3 0.1
Maternal smoking around birth 0.9 1.4 4.8 0.3 0.7 0.5 -0.7 -1.0 -1.5 -0.9 -1.7 -0.7 -2.2
Fed-up feelings 1.5 2.8 5.6 -2.3 -2.4 -2.2 0.7 1.4 0.8 2.2 -1.8 -0.5 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.0 -0.2 -0.0 0.2 0.9 -0.1 0.6 0.7 -1.2 -0.1 -1.4
Relative age voice broke 0.4 0.6 1.5 -0.7 -0.9 -0.9 -0.5 1.2 -0.5 0.0 0.7 -0.4 0.9
Taking other prescription medications 0.4 0.6 2.4 0.3 0.4 0.7 1.0 -0.2 -0.4 0.5 -1.6 1.1 -0.5
Age when periods started (menarche) 0.6 1.3 3.6 1.7 1.9 1.8 0.5 -1.3 0.2 -0.8 -0.2 0.9 -0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 -0.7 -0.7 -0.7 1.0 0.6 0.8 -0.5 -1.0 0.9 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.1 1.8 1.1 0.7 -0.3 -0.9 -0.6 -1.4 1.1 -0.9 -1.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.1 0.2 0.6 0.7 0.5 0.6 0.9 0.5 0.6 0.4 1.4
Qualifications: CSEs or equivalent 1.8 2.3 5.4 -2.3 -2.3 -2.1 0.3 1.3 0.1 2.3 -0.3 -0.2 -0.8
Serious illness, injury or assault to yourself 0.4 0.4 2.1 -0.5 -0.4 -0.1 0.7 0.5 -0.1 0.6 -1.4 -0.0 -0.9
High blood pressure 0.3 0.9 3.1 0.3 0.7 0.8 0.4 -0.4 1.0 0.2 1.7 1.8 0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.9 0.5 0.3 0.5 0.3 1.0 -1.4 -0.3 1.0 -0.3 -1.2
Multivitamins +/- minerals 0.2 0.3 1.2 0.0 -0.6 -0.5 -0.2 -0.2 0.4 0.4 -0.4 -0.6 -1.1
Stomach or abdominal pain in last month 0.6 0.7 2.9 0.9 1.0 0.9 1.0 -0.4 1.7 0.2 -0.3 0.5 -0.5
Supplements: Glucosamine 0.4 0.6 2.4 1.0 0.7 0.8 0.7 -0.6 0.5 -0.2 -0.1 -0.5 -1.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.3 -1.1 -1.5 -1.5 0.1 -0.4 0.1 0.6 -1.2 0.4 -0.1
Medication: Atenolol 0.4 0.5 2.2 0.1 -0.1 0.1 0.7 1.5 0.4 0.6 0.9 0.8 0.9
Medication: Levothyroxine sodium 0.4 0.8 1.7 1.1 1.1 0.9 -0.1 -1.2 -0.1 -1.3 -0.0 -1.0 -0.6
Sitting height 0.1 0.6 2.6 -0.1 -0.5 -0.7 0.5 1.0 0.1 0.4 1.6 0.8 -0.2
Chronic bronchitis/emphysema (father) 0.5 0.6 2.4 0.1 0.1 0.2 -0.9 0.1 -0.3 -0.4 -0.7 -1.5 -1.5
High blood pressure (mother) 0.8 1.1 3.0 -1.2 -1.5 -1.6 -0.4 0.9 -0.1 0.2 1.7 0.3 0.9
Body mass index (BMI) 0.6 2.5 4.6 2.0 2.1 2.1 -0.6 -2.0 -1.5 -1.8 0.5 -1.2 -0.8
Impedance of leg (left) 1.3 6.3 14.1 -3.8 -3.7 -3.5 -1.6 3.3 1.1 2.6 -0.6 -0.4 1.2
Leg predicted mass (left) 0.1 0.7 1.5 1.2 1.0 0.8 0.2 -1.2 -0.3 -1.2 0.9 0.0 -0.2
Trunk fat mass 0.1 0.5 2.1 0.4 0.5 0.4 -0.7 -1.4 -0.7 -0.6 -0.2 -0.8 -0.3
Waist circumference 0.3 1.1 3.1 0.7 1.1 1.1 -1.2 -1.8 -0.6 -1.2 -0.1 -1.2 0.2
Number of incorrect matches in round 0.5 0.8 3.5 0.4 0.7 1.0 1.0 -0.8 1.9 0.5 -1.0 0.1 0.1
Past tobacco smoking 0.9 1.7 7.3 0.3 0.5 0.7 1.6 1.4 0.3 -0.0 1.5 2.7 1.4
Alcohol usually taken with meals 0.2 0.3 1.9 0.2 0.2 0.2 0.4 0.1 -0.2 0.6 0.4 1.4 -0.3
Nervous feelings 1.7 3.2 10.5 -1.3 -1.3 -1.2 1.1 2.8 -0.6 0.6 1.1 2.5 3.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.6 -0.8 -0.7 -0.7 -0.5 0.4 0.6 0.5 -0.5 -0.7 0.6
Hearing difficulty/problems with background noise 0.4 0.7 3.7 -0.4 -0.2 -0.1 1.0 -0.6 -0.3 0.6 -1.9 1.1 0.2
Hair/balding pattern: Pattern 2 0.8 1.0 2.6 -0.4 -1.0 -1.4 -0.1 -0.9 1.2 -1.6 -1.2 0.3 0.2
Had menopause 0.7 0.8 3.5 1.1 1.1 0.9 0.6 -0.6 -0.2 -1.9 -0.9 0.4 -0.2
Had other major operations 0.4 0.5 1.1 -0.6 -0.6 -0.3 0.4 0.9 -0.9 0.9 1.0 0.0 -0.7
Forced vital capacity (FVC) 0.1 0.4 1.2 -0.6 -1.0 -1.1 0.2 0.5 -0.2 0.5 0.0 0.0 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 4.2 2.0 1.4 1.0 -0.5 -0.9 -0.9 -1.8 1.1 -1.4 -1.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.5 0.4 0.3 0.5 0.4 1.2 0.8 -0.1 -0.1 1.1 -0.3
Qualifications: None of the above 0.5 1.0 3.3 1.0 0.9 1.0 0.9 -0.7 0.3 -0.2 -1.6 0.1 -1.8
Financial difficulties in last 2 years 0.2 0.3 0.6 0.7 0.3 0.5 0.8 -0.3 0.8 0.5 0.2 0.1 -0.3
Mouth/teeth dental problems 0.4 0.6 2.5 -0.4 -0.2 -0.2 -0.1 -1.6 1.0 0.6 0.2 0.9 0.9
Heart attack 0.5 0.7 1.5 -1.0 -1.2 -1.2 -0.3 -0.5 -0.8 0.6 -0.6 0.4 -1.1
Allergy 0.3 0.6 2.7 -0.2 -0.0 -0.3 -0.4 -0.1 1.6 -0.1 0.4 0.8 1.6
Pain all over the body in last month 0.8 0.9 2.2 -0.4 0.0 0.3 -1.3 0.7 -0.5 0.2 1.4 -1.4 -1.5
Diabetes (self-reported) 0.9 1.5 5.5 -1.5 -1.1 -1.2 -2.4 0.8 0.6 0.0 0.2 -1.8 -0.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.3 0.1 0.3 0.3 -0.4 1.1 -0.3 -0.6 0.7 -0.9 -0.6
Medication: Ramipril 1.1 1.4 3.3 -1.8 -1.7 -1.6 -0.2 -0.5 1.1 1.2 -0.7 0.7 0.9
Medication: Simvastatin 0.4 0.5 1.5 0.1 0.3 0.4 1.2 0.1 0.4 0.7 -1.2 1.2 0.3
Fluid intelligence score 1.8 3.7 9.8 -2.7 -2.6 -2.6 -1.4 3.1 1.3 0.9 -0.2 -0.6 0.8
Illnesses of siblings 1.6 2.2 4.5 -1.7 -1.9 -1.6 0.7 0.6 0.3 1.6 -1.4 1.8 2.1
Neuroticism score 0.9 1.9 5.2 -1.7 -1.6 -1.6 0.6 1.0 0.5 1.1 -2.3 0.7 1.4
Weight 0.2 0.8 1.7 1.2 1.1 1.0 -0.2 -1.3 -0.5 -1.3 0.5 -0.3 -0.1
Impedance of arm (right) 0.7 3.1 6.4 -2.5 -2.5 -2.5 0.5 1.4 1.2 2.4 -1.2 0.8 1.0
Arm fat percentage (right) 0.2 1.0 2.8 1.0 1.2 1.2 -0.4 -1.7 -1.2 -0.9 -0.1 -0.5 -0.4
Trunk fat-free mass 0.2 0.9 2.4 1.5 1.3 1.1 0.7 -0.7 0.8 -1.2 0.9 0.5 0.0
Hip circumference 0.2 0.8 2.0 1.2 1.4 1.4 0.0 -0.9 -0.6 -1.2 0.3 -0.3 -0.6
Time employed in main current job 0.4 0.5 2.1 -0.5 -0.7 -0.6 0.3 -0.1 1.1 1.4 -0.4 -0.6 -0.1
Alcohol intake versus 10 years previously 0.4 0.6 1.8 0.4 0.5 0.6 -0.1 -0.2 1.3 0.2 -0.1 -1.3 -1.1
Father’s age at death 1.2 1.6 8.6 -0.0 -0.1 -0.1 0.5 -1.2 2.9 0.6 -1.3 0.5 1.9
Worrier / anxious feelings 0.5 0.9 3.0 -0.3 -0.6 -0.6 1.4 -0.1 0.7 0.4 -1.7 1.1 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 6.2 0.7 0.6 0.9 2.5 -0.3 0.7 1.9 -0.8 0.8 -0.9
Falls in the last year 0.4 0.5 1.6 0.4 0.2 0.5 1.2 0.4 -0.5 1.3 -0.3 0.9 0.5
Hair/balding pattern: Pattern 3 0.6 0.9 4.4 -0.6 -0.7 -0.6 -0.8 0.9 -0.7 0.7 0.8 -0.6 2.1
Number of live births 0.3 0.5 0.8 0.8 0.8 0.7 -0.1 0.6 0.5 -0.9 0.9 0.2 0.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.7 -1.1 -1.3 -1.3 -0.7 1.2 -0.9 0.6 0.8 -0.4 0.0
Pulse rate 0.3 0.5 1.5 0.8 1.1 1.2 -0.2 -0.7 -0.0 -0.0 1.1 -0.3 -0.0
Happiness 2.2 2.7 6.7 -2.0 -1.7 -1.6 0.7 -0.5 2.3 2.6 -1.6 0.4 1.5
Noisy workplace 0.7 0.8 2.0 -0.9 -1.0 -0.8 -0.9 0.4 0.9 1.1 -0.5 -1.4 0.8
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.4 -0.1 -0.1 -0.1 0.1 -0.5 0.0 0.4 -0.6 0.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 2.0 -0.4 -0.4 -0.3 -1.4 0.9 -0.1 -0.5 0.5 -0.6 -0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 3.8 1.2 1.3 1.1 -0.2 0.4 -0.1 -1.9 -1.2 -0.2 -0.7
Asthma 0.9 1.8 3.3 -1.4 -1.6 -1.6 -1.1 -0.9 -0.3 0.6 -1.8 -1.7 -1.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 6.8 0.3 0.1 -0.1 -1.1 -0.8 0.2 -0.7 1.5 -1.2 -2.6
Medication: Cholesterol lowering 0.3 0.5 2.2 -0.7 -0.8 -0.8 0.3 -0.6 0.2 0.9 -1.5 0.4 -0.1
Depression (self-reported) 0.4 0.5 1.1 0.8 0.6 0.6 0.8 0.6 -0.1 0.7 0.7 1.0 -0.4
Medication: Lansoprazole 0.7 0.8 2.5 -0.5 -0.9 -1.1 -0.9 0.7 -1.6 -0.7 0.7 -1.1 -0.3
Prospective memory result 0.6 0.7 2.0 0.9 0.7 0.7 -0.7 0.8 0.3 -0.4 1.4 -0.9 -1.0
Lung cancer (father) 0.8 1.0 1.7 0.5 0.2 0.4 1.3 -1.1 1.2 1.0 -1.3 1.3 0.4
Illnesses of mother 0.6 0.7 2.8 0.3 0.4 0.6 1.3 0.4 0.3 0.7 -1.1 0.1 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.1 -0.5 -0.9 -1.0 -0.2 0.9 -1.1 0.5 0.9 -0.0 0.5
Pulse wave Arterial Stiffness index 0.2 0.2 1.1 -0.1 0.2 0.2 0.3 0.4 0.0 -0.4 -0.5 1.0 -0.1
Impedance of arm (left) 0.6 2.6 7.0 -2.5 -2.6 -2.6 -0.1 0.6 0.3 1.7 -1.4 0.3 0.6
Arm fat mass (right) 0.3 1.1 2.5 1.1 1.2 1.2 -0.6 -1.6 -1.4 -1.3 0.4 -0.8 -0.4
Trunk predicted mass 0.2 1.0 2.6 1.6 1.4 1.2 0.8 -0.8 0.8 -1.1 0.9 0.6 0.0
Standing height 0.2 2.0 3.8 -1.4 -1.8 -1.9 0.8 1.3 1.9 0.9 0.2 1.6 1.4
Length of working week for main job 0.2 0.3 1.5 -0.5 0.1 0.4 -0.3 0.4 0.3 1.2 -0.0 -0.1 0.6
Exposure to tobacco smoke at home 0.5 0.6 1.8 0.4 0.8 0.8 0.0 -1.0 -1.3 0.2 0.0 -0.8 -1.1
Breastfed as a baby 0.8 1.0 4.3 -0.4 -0.2 0.0 0.8 0.4 2.1 0.8 -1.3 1.3 1.1
Tense / ‘highly strung’ 1.0 1.7 4.1 -1.6 -1.6 -1.6 0.8 0.2 0.5 0.9 -2.0 1.6 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.6 -0.6 -0.7 -0.4 1.5 1.8 0.4 1.8 0.1 2.1 0.7
Hair/balding pattern: Pattern 4 0.4 0.9 3.6 -0.2 -0.3 -0.3 -1.0 -0.3 0.1 0.5 1.7 -0.7 -1.9
Birth weight of first child 0.9 1.6 4.6 -1.4 -1.7 -1.3 1.1 -0.3 0.3 2.1 -1.5 0.7 0.7
Peak expiratory flow (PEF) 1.2 2.9 6.7 -1.3 -1.1 -1.1 -2.4 2.0 -2.6 0.6 1.6 -1.9 -1.3
Pulse wave reflection index 1.4 1.7 4.6 -2.1 -1.9 -1.9 -0.2 1.3 1.1 0.9 -0.6 0.6 0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 -0.6 -0.7 -0.7 0.4 -0.0 0.0 0.5 -0.4 -0.6 -0.2
Loud music exposure frequency 0.8 0.8 5.6 -0.5 -0.4 -0.2 0.7 0.5 -0.6 2.4 1.0 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 -0.9 -1.0 -1.0 -0.7 0.6 0.1 -0.1 0.7 -0.6 -0.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.1 -0.5 -0.8 -0.6 0.5 0.4 0.3 1.7 0.3 -1.1 0.2
Blood clot in the leg (DVT) 1.6 2.1 4.0 1.7 1.8 1.9 2.0 -1.0 0.5 -1.0 -0.8 1.9 0.7
Medication: Paracetamol 0.3 0.6 2.0 -0.7 -0.4 -0.6 -0.1 -0.2 -1.2 -1.4 -0.4 -0.0 -0.9
Headache pain in last month 0.4 0.7 2.9 -0.2 -0.2 -0.1 1.4 0.7 0.4 0.5 -1.0 1.7 -0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.7 -0.2 -0.1 -0.2 -0.7 0.9 -1.4 -0.7 1.3 -1.6 -0.3
Glaucoma (self-reported) 0.3 0.4 2.0 0.2 -0.0 -0.1 0.1 0.4 1.4 -0.4 -0.4 0.6 1.0
Gout (self-reported) 0.5 0.7 3.0 0.2 0.3 0.6 1.2 -0.2 -0.1 1.7 -0.2 0.9 1.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.2 0.3 0.2 0.0 -0.1 -0.7 0.8 -1.1 0.1 -0.9 -0.1
Medication: Amlodipine 0.4 0.6 3.3 0.8 0.6 0.7 0.8 0.0 1.8 0.5 -0.3 0.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.7 -0.4 -1.2 -1.3 -0.7 -0.1 -0.8 -1.1 -0.9 -0.6 -0.2
Birth weight 0.5 1.1 4.2 -0.6 -0.9 -0.8 0.9 0.2 1.3 0.0 -0.9 2.0 1.3
Chronic bronchitis/emphysema (mother) 0.7 0.8 4.2 0.1 -0.0 -0.2 -0.2 -2.0 -0.1 -0.2 -2.0 0.2 -0.3
High blood pressure (siblings) 0.8 1.1 2.5 1.1 1.6 1.4 -0.3 -0.9 -0.7 -1.6 1.1 -0.5 -0.6
Forced vital capacity (FVC), Best measure 0.1 0.3 0.9 -0.3 -0.8 -0.9 0.3 0.5 -0.4 0.2 0.3 0.5 0.9
Body fat percentage 0.1 0.6 1.6 0.1 0.3 0.3 -1.3 -1.2 -1.1 -0.7 -0.4 -0.9 -0.1
Leg fat percentage (right) 0.2 0.7 1.5 0.5 0.8 0.8 -1.2 -1.0 -0.8 -1.0 -0.6 -0.6 0.3
Arm fat-free mass (right) 0.1 0.5 1.1 1.0 0.9 0.8 -0.0 -0.6 0.0 -1.0 0.9 0.0 -0.2
Exposure to tobacco smoke outside home 1.6 2.2 7.5 1.7 1.7 1.5 0.1 -2.7 -1.5 -1.7 -0.7 0.2 -0.3
Comparative body size at age 10 1.3 3.5 11.2 2.7 2.6 2.4 0.2 -1.8 -1.0 -3.3 0.2 -0.3 -0.4
Number of full brothers 0.6 0.8 2.6 -0.8 -0.7 -0.6 -0.8 1.0 -0.7 0.7 0.2 -1.6 -1.0
Worry too long after embarrassment 1.4 2.4 7.1 -2.2 -2.5 -2.7 -0.7 0.8 0.1 0.3 -1.5 0.9 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 4.8 -0.1 0.2 0.6 1.6 2.2 1.6 1.7 0.2 1.8 0.5
Wheeze or whistling in the chest in last year 0.5 0.9 6.2 -0.4 -0.7 -0.8 -0.4 -0.8 0.6 -0.6 -2.5 -0.3 -0.3
Number of children fathered 0.9 1.0 4.8 -0.1 -0.1 -0.4 -0.6 0.8 -0.9 -0.7 2.2 -1.3 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 4.0 -0.8 -1.4 -1.6 -0.7 -1.1 -0.1 -0.1 -1.4 -2.0 -0.2
Age at first live birth 0.5 0.8 4.1 -0.9 -0.6 -0.3 0.9 0.9 0.5 2.0 -0.2 1.0 -0.4
Pulse wave peak to peak time 0.1 0.2 0.8 0.0 -0.3 -0.3 -0.3 -0.2 -0.1 0.4 0.5 -0.9 -0.1
Health satisfaction 0.3 0.4 2.8 0.0 0.2 0.3 0.3 0.6 1.7 0.1 -0.4 0.0 -0.3
Shortness of breath walking on level ground 2.4 2.9 7.5 1.9 2.1 2.2 2.7 -1.0 0.6 -0.7 -1.0 2.4 -0.1
Qualifications: College or University degree 0.2 0.7 3.0 -0.9 -0.7 -0.8 -1.0 0.2 -0.7 -0.3 0.5 0.4 1.7
Eye problems/disorders: None of the above 0.4 0.4 1.5 0.6 0.5 0.4 -0.9 -0.2 0.3 -0.6 0.7 -1.2 -0.6
Mouth/teeth dental problems: Loose teeth 1.4 1.7 4.1 -1.9 -2.0 -1.8 -0.7 0.2 0.1 1.7 -1.3 -0.8 0.8
Emphysema/chronic bronchitis 0.6 0.6 1.6 -0.5 -0.5 -0.3 1.0 0.2 -0.3 1.3 -0.9 -0.7 -1.3
Medication for pain relief, constipation, heartburn 0.3 0.6 2.7 0.2 0.2 0.4 0.5 0.9 0.5 1.1 0.2 -0.2 1.6
Neck or shoulder pain in last month 0.7 1.0 2.8 -0.7 -0.5 -0.2 0.6 1.7 1.6 1.0 -0.4 0.5 -1.5
Medication: Blood pressure 0.4 0.7 2.5 -0.1 -0.0 0.1 0.6 -0.5 1.6 0.7 -0.8 1.5 0.4
Angina (self-reported) 0.8 1.1 3.0 -1.3 -1.5 -1.7 -1.7 0.6 -0.2 -0.8 -0.4 -0.1 -0.0
Migraine (self-reported) 2.3 2.9 8.1 2.8 2.5 2.3 0.4 -0.8 -1.1 -1.8 1.4 -0.9 -0.8
Medication: Ibuprofen 0.6 0.8 2.2 -0.3 -0.6 -0.7 -1.1 -0.2 0.3 -0.5 1.1 -1.3 -1.5
Medication: Allopurinol 0.6 0.8 2.8 -0.3 -0.2 0.1 0.7 0.4 0.4 1.7 -0.9 1.0 1.6
Medication: Omeprazole 1.3 1.5 5.2 -1.8 -2.2 -2.3 -1.1 0.4 -0.1 0.5 -0.1 0.1 0.3
Medication: Seretide 50 evohaler 1.7 2.0 10.3 -0.3 -0.4 -0.5 -1.6 -0.5 -1.2 -0.1 -0.1 -2.2 -3.2
Mean time to correctly identify matches 1.1 2.1 5.9 1.4 1.4 1.5 2.0 -1.8 2.4 0.3 -0.4 0.5 1.1
Heart disease (mother) 0.4 0.4 1.1 0.3 0.8 0.9 -0.2 0.5 -1.0 0.4 0.3 0.3 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.8 5.5 -1.7 -1.9 -2.0 -0.6 0.3 -1.3 0.2 -2.4 -0.1 -0.5
Whole body fat mass 0.1 0.6 1.8 0.4 0.5 0.5 -0.9 -1.3 -1.0 -0.8 -0.1 -0.8 -0.3
Leg fat mass (right) 0.2 1.0 2.1 0.9 1.1 1.0 -1.1 -1.3 -1.1 -1.4 -0.1 -0.6 -0.1
Arm predicted mass (right) 0.1 0.6 1.3 1.2 1.0 0.9 -0.1 -0.7 -0.0 -1.0 0.9 -0.1 0.1
Pulse rate, automated reading 0.2 0.6 1.4 -1.1 -0.8 -0.4 -0.6 0.2 -0.3 0.9 -0.7 -1.2 -0.7
Alcohol intake frequency. 0.8 1.8 4.4 2.0 2.0 2.1 1.8 0.5 -0.2 -0.8 0.9 0.9 -0.6
Comparative height size at age 10 0.1 0.3 1.5 -0.1 -0.4 -0.5 0.1 0.7 -0.6 -0.5 1.2 -0.2 0.0
Number of full sisters 0.9 1.1 4.1 0.3 0.1 0.1 -0.2 -0.3 -1.4 0.5 -0.6 -2.0 -2.0
Suffer from ‘nerves’ 0.8 1.2 4.7 -1.2 -1.3 -1.2 -0.6 2.2 0.7 1.0 0.4 -0.8 0.3
Overall health rating 0.3 0.6 2.2 0.6 0.2 0.1 1.5 -0.8 0.6 -0.2 -1.2 0.6 -0.7
Chest pain or discomfort 0.3 0.4 1.0 -0.8 -0.5 -0.6 0.3 0.0 0.0 -0.6 -1.0 0.8 0.7
Had major operations 0.4 0.4 1.1 -0.7 -0.6 -0.3 0.0 0.8 0.4 1.0 0.3 -0.7 -1.0
Age at last live birth 1.1 1.6 4.5 -1.7 -1.4 -1.2 0.3 1.9 0.9 2.1 0.3 0.2 0.2
Family relationship satisfaction 0.8 1.0 4.7 -1.0 -0.5 -0.7 -0.6 -0.9 2.2 -0.8 -1.1 0.5 0.1
Leg pain on walking 1.9 2.4 9.5 0.8 1.0 1.3 3.1 1.1 -0.3 0.4 -1.5 2.7 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 1.1 0.7 0.7 0.8 -1.1 -0.1 0.0 0.4 0.1 -0.5
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.6 1.8 1.8 1.4 0.6 -1.7 -0.5 -1.9 -0.1 0.8 -0.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 3.0 -0.6 -0.6 -0.6 -0.3 -0.1 0.1 1.7 0.7 -0.8 -0.1
Medication: Aspirin 0.6 0.8 1.6 1.1 1.2 1.2 0.5 -1.3 1.0 -0.1 -0.0 0.5 -0.8
Supplements: Vitamin C 1.3 1.5 5.2 0.6 0.6 0.7 2.3 -1.8 1.5 0.4 -1.3 1.3 -0.5
Knee pain experienced in last month 0.6 0.9 2.7 0.6 0.4 0.5 1.6 0.2 -1.0 -0.2 -1.3 0.5 -1.5
Hypertension (Self-reported) 0.3 0.8 4.1 -0.0 0.5 0.6 0.1 -0.1 0.9 0.4 2.0 1.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.1 -1.2 -1.5 -1.4 -0.8 1.2 -0.8 0.4 0.1 -0.7 -0.3
Illnesses of father: Heart disease 0.7 1.0 2.6 -1.3 -1.2 -1.1 0.1 -0.6 -0.5 1.6 -0.8 0.4 1.3
Illnesses of siblings: Diabetes 1.2 1.5 9.9 0.5 0.4 0.4 -0.4 -0.0 -1.0 -0.9 -0.9 -1.3 -3.1
Smoking status: Previous 0.7 1.0 5.4 -0.4 -0.7 -0.8 -0.8 -0.9 -0.0 0.6 -0.8 -2.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 5.3 -1.7 -2.0 -2.3 -0.4 -0.0 1.3 0.9 0.6 0.2 1.3
Whole body fat-free mass 0.1 0.7 1.6 1.3 1.0 0.9 0.5 -0.7 0.3 -1.1 1.1 0.3 -0.0
Leg fat-free mass (right) 0.1 0.5 1.5 0.9 0.6 0.5 0.1 -1.0 -0.2 -0.8 1.2 -0.3 -0.5
Arm fat percentage (left) 0.3 1.4 4.1 1.0 1.1 1.1 -0.8 -2.0 -1.7 -1.1 -0.2 -1.0 -0.6
Average weekly red wine intake 0.4 0.6 2.1 0.3 0.4 0.2 -0.7 -1.4 -0.9 -1.0 -0.8 0.4 0.4
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.2 0.9 0.7 0.6 -1.0 -0.4 -0.6 -1.3 0.4 -1.5 -0.3
Mood swings 0.7 1.2 5.2 0.0 0.1 0.1 1.8 -0.3 0.2 -0.2 -2.3 1.8 0.5
Loneliness, isolation 0.8 1.1 3.8 -0.9 -0.9 -0.7 0.9 -0.1 1.6 1.5 -1.9 0.1 -0.3
Long-standing illness, disability or infirmity 0.3 0.4 2.4 0.0 0.2 0.4 0.5 0.3 -0.2 0.3 -0.7 0.7 -1.6
Ever had bowel cancer screening 1.2 1.4 5.3 1.2 1.4 1.5 1.1 -0.4 0.2 -0.4 -2.3 1.4 -0.5
Diabetes diagnosed by doctor 0.4 0.6 2.8 -0.6 -0.4 -0.4 -1.7 0.7 0.5 -0.3 0.4 -1.2 0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 3.1 -0.9 -1.0 -0.8 -0.8 0.3 -0.6 1.5 -0.3 -1.8 -1.5
Friendships satisfaction 2.0 2.5 6.1 -2.1 -1.7 -1.7 0.8 -0.6 2.5 1.2 -1.5 1.8 1.2
Qualifications: nursing, teaching 1.8 2.7 5.8 2.4 2.1 1.9 2.1 -2.2 0.0 -0.7 -0.5 1.8 -0.7
Commuting to job workplace: Walk 0.8 0.8 1.8 -1.0 -1.2 -1.2 -0.6 0.3 0.9 0.6 -0.2 -1.0 -1.3
Eye problems/disorders: Cataract 1.5 1.7 3.5 -0.8 -0.8 -0.6 1.7 0.3 1.5 1.9 -1.6 1.8 1.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 4.7 0.5 0.2 0.2 -0.6 0.5 -1.7 -0.6 1.8 -2.2 -1.6
Medication for cholesterol 0.7 1.1 3.4 1.2 1.2 1.1 0.8 -1.3 0.2 -0.7 -1.9 0.4 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.6 -1.5 -1.6 -1.6 -0.2 1.1 0.9 -0.2 -0.3 0.9 1.5
Back pain experienced in last month 0.6 0.9 3.3 -0.2 -0.6 -0.8 1.0 -0.1 0.5 -0.4 -1.7 0.4 -1.8
Mineral and other dietary supplements 1.0 1.3 4.8 -0.8 -0.3 -0.2 -1.0 1.8 -0.3 -0.2 2.2 -0.2 1.9
Breast cancer (self-reported) 2.0 2.4 5.7 -1.9 -2.2 -2.4 -1.1 1.4 1.1 0.0 -0.4 0.4 2.1
Asthma (self-reported) 1.0 2.1 4.2 -1.7 -1.9 -1.8 -1.1 -0.8 0.2 1.0 -2.1 -1.6 -1.1
Osteoporosis (self-reported) 0.9 1.2 2.9 -0.6 -0.9 -0.7 0.3 -0.7 1.6 1.2 -1.4 0.9 1.7
Osteoarthritis (self-reported) 1.9 2.4 5.2 2.0 1.9 2.1 2.3 0.2 -1.0 -0.7 0.7 1.4 -1.7
Medication: Aspirin 0.4 0.6 1.1 1.0 0.9 0.9 0.2 -0.9 0.9 -0.5 -0.1 0.3 -1.0
Medication: Gliclazide 0.2 0.3 1.2 -0.0 -0.1 -0.2 -0.8 0.0 0.3 0.1 0.7 -1.1 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.2 0.2 -0.0 -0.1 0.2 -0.6 1.1 -0.6 -0.9 0.6 -0.8
Smoking status: Current 0.2 0.4 1.0 -0.9 -0.5 -0.4 -0.7 0.4 0.4 0.2 -1.0 -0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.9 1.3 1.2 1.2 -0.1 -0.5 -2.0 -1.8 0.3 0.8 -0.3
Whole body water mass 0.2 0.9 2.1 1.5 1.3 1.1 0.5 -0.8 0.2 -1.1 1.1 0.3 -0.1
Leg predicted mass (right) 0.1 0.5 1.4 0.9 0.7 0.5 0.2 -1.1 -0.2 -0.8 1.2 -0.2 -0.5
Arm fat mass (left) 0.3 1.0 3.0 0.8 1.0 0.9 -0.8 -1.7 -1.3 -1.1 0.2 -0.9 -0.6
Number of self-reported non-cancer illnesses 0.4 0.7 1.9 1.0 0.9 1.1 1.2 0.3 0.3 -0.5 -0.2 1.4 -0.6
Average weekly champagne plus white wine intake 0.6 0.8 2.8 0.2 -0.0 -0.3 -1.3 0.5 -0.1 -1.2 1.4 -0.0 1.7
Miserableness 0.4 0.7 1.9 -0.9 -0.7 -0.6 1.2 0.2 -0.3 1.4 -1.1 0.5 0.4
Guilty feelings 0.6 0.8 3.2 -0.9 -0.8 -0.8 0.1 0.3 0.7 0.2 -1.8 0.7 1.3
Wears glasses or contact lenses 0.6 0.7 3.0 -0.6 -0.7 -0.5 0.4 0.8 0.2 0.4 -0.6 1.2 1.7
Ever taken oral contraceptive pill 1.2 1.3 2.9 -1.7 -1.6 -1.6 -1.7 0.9 -0.1 0.4 -0.9 -0.7 -0.2
Hearing aid user 2.4 2.8 7.1 -2.1 -2.4 -2.0 -0.9 1.7 0.5 2.7 -0.4 -1.4 0.2
Mother’s age at death 0.5 0.6 1.9 0.9 1.0 0.8 0.3 -0.0 -1.0 -1.4 0.5 0.8 0.2
Financial situation satisfaction 1.7 2.2 6.1 -1.6 -1.5 -1.4 0.8 -0.5 2.5 1.7 -2.0 0.6 0.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.1 0.8 0.6 0.9 0.8 0.3 0.3 1.0 0.3 -0.6 -0.3
Commuting to job workplace: Public transport 0.8 0.9 6.4 -0.5 -0.6 -0.4 0.3 -0.6 0.9 0.6 -2.5 -0.1 0.5
Eye problems/disorders: Glaucoma 0.3 0.4 1.5 0.5 0.4 0.5 -0.0 0.3 0.9 -0.5 0.6 0.7 1.2
Medication: Blood pressure 0.2 0.4 1.9 -0.2 0.4 0.3 -0.7 -0.5 -0.3 -0.8 1.4 0.1 0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.4 5.2 0.3 0.6 1.1 2.0 0.8 -0.5 0.4 -2.3 1.0 -1.0
Supplements: Fish oil (including cod liver oil) 1.5 1.9 9.4 0.6 0.2 0.1 0.1 -1.9 -0.0 0.6 -1.8 -1.4 -3.1
High cholesterol (Self-reported) 0.2 0.4 1.3 0.5 0.6 0.8 0.4 0.1 1.1 0.8 -0.5 0.4 0.4
Medication: Bendroflumethiazide 0.8 1.3 6.6 0.7 1.1 1.0 -0.1 -0.8 -1.2 -0.2 2.6 -0.4 -1.1
Medication: Paracetamol 0.2 0.4 1.3 -0.7 -0.6 -0.8 -0.2 0.1 -0.7 -1.1 -0.6 0.3 -0.4
Medication: Lisinopril 1.2 1.5 7.3 0.6 0.7 0.6 1.2 -1.0 0.8 -1.2 -0.4 2.7 1.5
Medication: Atorvastatin 0.7 0.9 3.5 1.4 1.0 0.9 0.1 -1.9 0.7 -0.0 -0.1 -1.0 -0.4
Illnesses of father: High blood pressure 0.2 0.2 0.7 0.5 0.3 0.2 -0.3 -0.4 -0.2 0.1 0.8 -0.8 0.5
Alcohol drinker status: Never 2.4 2.8 7.0 2.6 2.5 2.5 1.6 -0.9 -0.6 -1.5 1.1 0.6 -1.2
Ever smoked 1.1 2.0 7.4 -0.1 0.1 -0.1 -1.9 -2.1 -0.3 -0.2 -1.5 -2.7 -1.3
Basal metabolic rate 0.1 0.6 1.4 1.2 1.0 0.8 0.2 -0.9 0.0 -1.1 1.0 0.1 -0.0
Leg fat percentage (left) 0.2 0.6 2.4 0.1 0.4 0.4 -1.6 -0.9 -0.8 -0.6 -0.1 -1.2 -0.1
Arm fat-free mass (left) 0.1 0.6 1.3 1.1 1.1 1.1 0.2 -0.4 0.2 -0.9 1.1 0.1 -0.0
Number of operations (self-reported) 0.8 1.1 2.4 -1.3 -1.4 -1.0 -0.2 1.6 -0.8 1.4 0.5 0.0 -1.1
Average weekly beer plus cider intake 0.4 0.6 2.5 -0.7 -0.7 -0.6 -1.1 0.2 -0.3 0.9 0.3 -1.6 -0.5
Irritability 0.7 1.1 4.2 -1.3 -1.2 -1.5 -0.6 0.3 -0.8 -0.6 -2.0 0.4 0.3
Risk taking 0.9 1.4 6.0 0.3 0.9 1.1 -0.4 -0.9 -1.2 0.1 -0.9 -1.7 -2.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.0 0.5 0.4 0.3 0.5 -1.0 -0.9 -0.9 -0.1 0.8 0.2
Fractured/broken bones in last 5 years 0.5 0.7 2.9 0.3 0.2 0.0 0.6 -0.3 -0.1 -1.1 -0.2 1.7 1.5
Age started oral contraceptive pill 0.3 0.3 1.4 0.4 -0.0 -0.1 0.3 0.1 -0.8 -0.8 -1.2 0.4 0.3
Diastolic blood pressure, automated reading 0.2 0.6 2.0 0.3 0.3 0.1 -0.5 0.2 -1.3 -1.2 1.4 -0.6 0.0
Ever depressed for a whole week 0.7 0.9 4.8 -0.3 0.1 0.6 0.5 1.3 1.1 2.2 -0.4 -0.0 -0.8
Unable to work because of sickness or disability 0.4 0.6 1.4 0.2 0.2 0.5 0.9 0.6 -0.8 1.2 1.0 0.2 -1.2
Commuting to job workplace: Cycle 1.2 1.5 5.2 -1.6 -1.5 -1.2 -0.5 2.3 0.1 1.1 1.3 0.3 -0.3
Myopia 0.8 1.2 3.0 -1.7 -1.5 -1.4 -1.4 1.1 -0.0 0.8 -0.3 -0.9 -0.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 2.9 0.2 -0.1 -0.1 -0.0 0.4 -0.8 -0.2 -1.3 -1.7 -0.4
Cholesterol lowering medication 0.7 1.0 2.5 1.5 1.4 1.6 1.2 0.3 0.9 -0.1 0.2 0.4 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.3 -1.3 -1.5 -1.4 -0.8 0.0 0.4 1.0 -0.1 0.2 0.5
Pain experienced in last month 1.1 1.8 5.5 0.5 0.5 0.4 -2.1 -0.3 -0.9 -0.3 2.4 -1.5 1.9
Supplements: Calcium 0.6 0.6 3.4 0.3 0.3 0.4 0.3 -0.1 1.8 1.1 0.4 0.2 -1.0
Basal cell carcinoma (self-reported) 0.3 0.4 1.9 0.1 0.2 0.2 -0.6 -0.7 0.8 -0.5 -1.4 -0.5 0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.6 -1.1 -1.2 -1.2 -0.4 -0.3 -0.9 0.7 -0.4 0.2 -1.2
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 5.3 2.0 2.1 2.1 2.2 -1.4 0.7 -1.4 -1.1 2.3 0.8
Heart disease (siblings) 0.5 0.7 2.0 1.1 1.4 1.4 0.1 -0.2 -0.0 -1.1 0.3 -0.2 -0.2
Alcohol drinker status: Previous 0.5 0.5 1.4 0.4 0.6 0.9 1.1 -0.3 0.3 1.2 -0.2 0.6 0.8
Pack years of smoking 0.6 0.9 2.5 0.2 0.4 0.2 -1.0 -0.3 -1.6 -1.2 0.6 -1.0 -1.6
Impedance of whole body 1.0 4.9 12.1 -3.4 -3.5 -3.4 -0.6 2.2 0.6 2.4 -1.1 0.1 1.1
Leg fat mass (left) 0.2 0.8 1.8 0.6 0.8 0.7 -1.3 -1.3 -1.1 -1.2 0.0 -0.9 -0.4
Arm predicted mass (left) 0.1 0.5 1.0 1.0 1.0 0.9 0.2 -0.3 0.3 -0.9 0.9 0.3 0.1