TWAS hub - CARNS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.267	0.098	9.3e-03	-0.012	NA	0.003	NA	-0.010	9.4e-01	NA	2.6e-01	NA	7.6e-01
2	GTEx	Colon Transverse	0.144	0.067	5.7e-03	0.034	NA	0.031	NA	0.062	9.2e-03	NA	1.3e-02	NA	6.6e-04
3	GTEx	Heart Left Ventricle	0.133	0.060	3.2e-03	0.139	NA	0.103	NA	0.119	7.6e-08	NA	4.1e-06	NA	6.8e-07
4	TCGA	Colon Adenocarcinoma	0.137	0.051	5.8e-11	0.145	0.184	0.157	NA	0.171	1.0e-08	7.1e-11	2.4e-09	NA	4.0e-10
5	TCGA	Rectum Adenocarcinoma	0.410	0.153	2.0e-04	0.097	0.153	0.107	NA	0.116	2.8e-03	2.0e-04	1.8e-03	NA	1.2e-03
6	TCGA	Stomach Adenocarcinoma	0.061	0.035	7.9e-04	0.059	0.040	0.048	NA	0.047	4.1e-05	7.0e-04	2.2e-04	NA	2.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heart disease (mother)	4.3	5.2	9.1	-0.8	2.7	1.6	2.4	3.0	2.5
Diabetes (mother)	3.4	4.4	6.2	-1.1	2.2	1.4	2.5	2.5	2.4
Lung cancer (father)	3.4	3.9	8.1	-0.1	-2.8	-0.9	-2.0	-2.7	-1.9
Medication: Ventolin 100micrograms inhaler	3.4	4.3	6.6	-0.6	-1.9	-1.9	-2.5	-2.6	-2.3
Average weekly red wine intake	3.4	5.1	8.5	-0.1	2.6	-0.3	2.9	2.8	2.6
Myopia	3.3	4.8	9.8	0.8	3.1	0.9	2.4	2.7	2.2
Number of full sisters	3.1	3.8	5.5	1.2	2.3	-1.6	2.1	2.1	2.1
Illnesses of mother	3.0	3.7	7.0	-0.3	-2.3	-0.5	-2.2	-2.6	-2.1
Medication: Lansoprazole	2.9	3.3	11.6	1.4	1.7	-3.4	1.2	0.6	1.1
Loneliness, isolation	2.9	4.0	9.8	-2.0	0.7	3.1	1.6	2.1	1.7
LDL Cholesterol	2.6	4.2	14.6	-3.8	-1.1	0.0	-2.2	-1.6	-1.4
Vitamin and mineral supplements	2.6	3.5	5.6	1.0	-1.8	-1.6	-2.1	-2.4	-2.1
Multivitamins +/- minerals	2.6	3.3	4.8	-0.8	1.4	1.9	2.2	2.1	2.1
Serious illness, injury or assault to yourself	2.5	3.1	5.6	0.4	2.4	0.0	1.9	2.3	2.0
Happiness	2.3	2.7	4.8	0.5	1.6	1.4	2.2	1.9	1.8
Medication: Cholesterol lowering	2.3	3.6	6.4	-2.3	-0.9	1.8	-2.5	-1.2	-2.1
High cholesterol (Self-reported)	2.3	4.1	8.0	-2.1	-1.3	1.3	-2.8	-1.7	-2.3
Breast cancer (self-reported)	2.1	2.5	4.0	1.2	1.9	0.6	2.0	1.3	2.0
Smoking status: Current	2.1	3.3	6.4	-2.0	-2.5	0.2	-1.7	-2.0	-1.6
Ovarian Cancer	2.0	2.6	5.8	-2.4	2.0	0.9	0.8	1.5	1.5
Impedance of leg (right)	2.0	9.8	23.5	1.4	-3.5	-0.1	-3.2	-4.8	-3.2
Hair/balding pattern: Pattern 3	2.0	3.0	5.7	1.1	2.2	-0.2	1.8	2.4	1.6
Leg predicted mass (right)	2.0	10.6	24.4	-0.4	1.9	0.9	4.8	3.4	4.9
HbA1C	1.9	2.1	3.4	-0.9	-1.6	1.4	-1.8	-1.4	-1.4
Supplements: Zinc	1.9	2.1	3.4	-0.7	-0.2	1.5	1.7	1.8	1.9
Maternal smoking around birth	1.9	2.7	10.0	-3.2	-0.8	0.6	-1.6	-1.1	-1.2
Impedance of leg (left)	1.9	9.4	22.5	0.5	-3.7	-0.1	-3.2	-4.7	-3.1
Medication: Seretide 50 evohaler	1.9	2.2	4.9	0.0	-1.7	-0.8	-1.7	-2.2	-1.5
Leg fat-free mass (right)	1.9	10.2	23.5	-0.5	1.8	0.9	4.7	3.3	4.8
Neuroticism (2016)	1.8	2.5	4.4	0.5	2.1	0.0	1.8	1.9	1.9
Leg fat-free mass (left)	1.8	9.4	22.2	-0.2	1.6	1.1	4.6	3.1	4.7
Current tobacco smoking	1.8	2.9	5.8	-1.9	-2.4	0.1	-1.6	-1.9	-1.5
Leg predicted mass (left)	1.8	9.3	21.9	-0.1	1.6	1.1	4.6	3.1	4.7
Forced vital capacity (FVC)	1.8	6.9	19.8	1.4	1.7	-0.4	4.5	1.0	4.0
Medication: Amlodipine	1.8	2.5	5.8	0.5	2.4	-1.9	1.5	1.2	1.3
Number of children fathered	1.8	2.0	3.0	1.3	-1.7	-0.0	-1.5	-1.7	-1.5
Whole body fat-free mass	1.8	10.0	24.5	0.1	1.6	0.7	5.0	2.9	4.9
Trunk fat-free mass	1.7	9.7	25.0	0.5	1.7	0.3	5.0	2.5	4.9
Breastfed as a baby	1.7	2.1	4.9	2.0	1.1	-2.2	1.1	0.4	0.8
Peak expiratory flow (PEF)	1.7	4.0	11.5	0.3	0.9	-1.3	3.4	0.9	3.0
Comparative height size at age 10	1.7	9.1	23.9	0.8	1.8	1.2	4.9	1.8	4.7
Alcohol drinker status: Never	1.7	2.0	4.2	2.0	0.2	-1.5	-1.4	-1.2	-1.6
Fractured/broken bones in last 5 years	1.7	2.2	3.7	-0.3	1.5	0.6	1.9	1.9	1.8
Bipolar Disorder (2018)	1.6	2.6	7.8	-2.8	0.7	1.3	0.5	1.9	1.3
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	14.8	0.8	1.7	-0.6	3.9	1.2	3.5
Trunk predicted mass	1.6	9.0	23.6	0.4	1.5	0.3	4.9	2.4	4.7
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.3	0.9	1.1	1.4	1.4	1.8	1.5
Number of full brothers	1.6	2.0	6.1	0.8	1.2	-2.5	1.4	0.8	1.1
Whole body water mass	1.6	9.4	23.1	0.1	1.5	0.7	4.8	2.7	4.8
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.1	0.8	1.3	0.6	1.8	1.5	1.7
Eye problems/disorders: Glaucoma	1.6	1.9	3.3	-0.9	-1.8	0.7	-1.6	-1.5	-1.5
Alcohol drinker status: Previous	1.6	1.8	3.6	-1.9	0.8	1.9	0.2	1.4	1.0
Smoking Status	1.5	3.6	10.8	-1.8	-3.3	-1.0	-1.2	-1.9	-1.2
Alcohol usually taken with meals	1.5	2.4	6.9	-0.7	1.0	-0.5	2.6	0.9	2.2
Number of live births	1.5	2.1	3.3	-1.8	1.5	0.6	1.2	1.5	1.7
Migraine (self-reported)	1.5	1.9	4.5	0.5	0.8	-2.1	1.5	1.2	1.6
Guilty feelings	1.5	2.2	4.4	-0.6	1.5	1.4	1.3	2.1	1.7
Medication: Atorvastatin	1.5	1.9	3.5	-1.9	-0.6	1.3	-1.8	-0.5	-1.5
Basal metabolic rate	1.5	8.5	21.1	0.0	1.2	1.0	4.5	2.6	4.6
Depression (Nagel 2018)	1.4	2.1	10.3	-1.5	-0.3	3.2	-0.1	0.2	0.1
Worry (Nagel 2018)	1.4	2.9	5.3	0.0	2.3	0.4	1.9	2.1	2.1
Fasting Glucose	1.4	1.6	3.5	0.7	-1.5	1.9	-0.6	-1.3	-1.2
Mean time to correctly identify matches	1.4	2.7	5.5	2.3	0.8	-2.2	1.5	0.7	1.6
Commuting to job workplace: Car/motor vehicle	1.4	1.5	2.2	-0.9	-0.8	1.5	-1.3	-1.5	-1.3
Bipolar Disorder or Schizophrenia	1.3	3.3	5.4	-1.9	2.1	0.3	1.5	2.3	2.1
Blood White Count	1.3	9.5	18.5	0.1	2.6	1.2	4.3	3.6	4.2
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.9	1.4	0.4	-1.7	1.5	0.7	1.4
Fed-up feelings	1.3	2.3	10.1	-1.1	-1.1	3.2	-0.8	-0.0	-0.7
Stomach or abdominal pain in last month	1.3	1.7	2.8	-0.1	-1.5	1.3	-1.4	-1.1	-1.7
Alcohol intake versus 10 years previously	1.3	1.9	9.5	-1.0	-0.5	3.1	-0.6	0.3	-0.4
Standing height	1.3	12.6	36.5	2.5	0.1	0.2	6.0	0.6	5.7
Supplements: Vitamin C	1.3	1.6	3.5	0.2	1.3	-0.5	1.2	1.9	1.5
Arm fat-free mass (left)	1.3	6.6	16.7	0.4	1.1	0.8	4.1	2.1	4.0
Schizophrenia (2014)	1.2	2.8	4.1	-0.5	2.0	1.3	1.8	2.0	1.9
Neuroticism	1.2	2.9	4.4	-1.9	2.0	1.0	1.3	2.1	1.7
Sensitivity / hurt feelings	1.2	2.1	4.1	-1.0	1.2	1.9	1.0	2.0	1.2
Pain all over the body in last month	1.2	1.3	6.4	-2.5	1.0	-0.1	-0.1	0.4	0.4
Mother’s age at death	1.2	1.5	5.7	0.9	1.0	-2.4	1.0	0.1	0.9
Arm predicted mass (left)	1.2	6.2	15.6	0.3	0.9	0.9	4.0	2.1	3.9
Reaction Time	1.1	2.0	3.6	1.9	1.0	-1.9	1.3	0.8	1.4
Primary Biliary Cirrhosis	1.1	1.6	2.9	-0.5	-1.7	-1.1	-1.4	-1.5	-1.0
Hand grip strength (left)	1.1	2.9	6.0	-0.5	1.7	0.1	2.4	1.7	2.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.3	-1.8	0.2	1.7	-1.0	0.2	-0.7
Worrier / anxious feelings	1.1	2.0	4.4	0.8	1.9	0.2	1.3	2.1	1.4
Pulse wave Arterial Stiffness index	1.1	1.2	3.4	-1.8	0.7	1.2	0.6	0.9	0.9
High blood pressure (siblings)	1.1	1.5	2.8	-1.4	0.5	1.7	1.0	1.6	0.8
Arm fat-free mass (right)	1.1	5.4	14.9	0.6	0.3	0.5	3.9	1.5	3.8
Pulse wave peak to peak time	1.1	1.3	4.0	2.0	-0.8	-1.2	-0.3	-1.0	-0.7
Arm predicted mass (right)	1.1	5.6	14.9	0.5	0.5	0.7	3.9	1.7	3.9
Back pain experienced in last month	1.1	1.6	3.4	-1.8	-1.8	1.6	-0.6	-0.2	-0.3
Impedance of whole body	1.1	5.8	13.9	0.9	-2.9	0.6	-2.4	-3.7	-2.4
Neuroticism (Nagel 2018)	1.0	2.4	3.6	-1.5	1.3	1.5	1.3	1.9	1.7
Height	1.0	19.4	54.6	4.6	0.1	0.5	7.4	-0.3	6.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.3	-1.5	-0.8	0.9	-1.3	-0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	4.5	0.9	-1.0	-1.4	-1.3	-2.1	-1.8
Depression (self-reported)	1.0	1.2	3.3	-0.8	-1.8	0.4	-1.1	-1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	2.9	1.7	0.4	-1.4	1.7	0.5	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	0.4	1.2	-0.8	1.5	1.1	1.2
Emphysema/chronic bronchitis	1.0	1.1	2.4	-0.1	-0.7	0.6	-1.5	-0.9	-1.6
Mood swings	1.0	1.8	3.1	-1.8	-1.3	0.6	-1.7	-1.2	-1.2
Friendships satisfaction	1.0	1.3	2.1	0.1	1.4	0.5	1.4	1.5	1.1
Schizophrenia (2018)	0.9	2.0	4.5	-0.1	2.1	-0.4	1.5	1.5	1.6
Relative age of first facial hair	0.9	1.8	8.4	1.3	0.6	-2.9	0.4	-0.1	0.5
Townsend deprivation index at recruitment	0.9	1.3	2.1	0.1	-1.1	-1.1	-1.4	-1.1	-1.4
Relative age voice broke	0.9	1.4	5.9	1.1	0.2	-2.4	-0.2	-0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.2	1.0	-1.1	-1.1	-1.5	-1.8	-1.7
Supplements: Glucosamine	0.9	1.1	2.2	-0.2	-0.7	-1.4	1.5	-0.6	1.3
Neuroticism score	0.9	1.9	2.9	-1.3	1.4	1.5	1.0	1.7	1.2
Weight	0.9	4.3	10.7	-0.2	-0.3	1.8	3.1	1.3	3.3
Birth weight of first child	0.9	1.7	3.8	-0.3	2.0	0.8	1.5	1.2	1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.6	-0.9	-1.2	-1.3	-1.2	-1.0	-0.9
Health satisfaction	0.9	1.2	2.5	-1.5	-0.7	0.7	-1.6	-0.5	-1.1
Age at last live birth	0.9	1.3	2.7	-1.5	0.1	-0.7	1.3	0.8	1.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	-0.5	-1.2	-0.7	-1.1	-1.3	-1.2
Eye problems/disorders: Cataract	0.9	1.0	4.6	0.7	0.4	-2.1	-0.3	-0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.0	-1.7	-0.9	-0.1	-1.7	-0.8	-1.3
Asthma (self-reported)	0.9	1.8	4.2	-0.8	-0.8	-1.0	-2.1	-1.2	-1.7
Number of self-reported non-cancer illnesses	0.9	1.5	3.2	-1.0	1.0	1.8	0.7	1.5	1.0
Average weekly champagne plus white wine intake	0.9	1.2	3.2	-0.9	-1.8	-0.5	-0.8	-1.5	-0.6
Financial situation satisfaction	0.9	1.1	2.3	-1.5	-0.1	1.2	-1.2	-0.7	-1.0
Medication: Lisinopril	0.9	1.2	3.0	0.5	1.6	0.9	0.7	1.7	0.6
Depressed Affect (Nagel 2018)	0.8	1.6	5.0	-2.1	-0.4	2.2	-0.3	0.4	0.2
Mean Putamen Volume	0.8	0.9	1.6	0.4	-1.1	0.8	-0.8	-1.3	-1.2
Blood Red Count	0.8	7.6	23.4	-0.9	4.8	-0.4	1.6	4.0	1.7
Medication: Metformin	0.8	1.1	6.3	-0.3	-0.2	2.5	-0.2	0.3	-0.0
Pack years adult smoking proportion	0.8	1.2	3.4	-1.1	1.8	1.3	0.3	0.9	0.4
Nervous feelings	0.8	1.6	3.3	0.6	1.0	0.5	1.7	1.3	1.8
Mouth/teeth dental problems	0.8	1.2	2.1	0.4	1.0	1.4	1.2	1.2	1.0
Exposure to tobacco smoke at home	0.8	0.9	1.3	1.1	-1.1	-0.4	-0.8	-1.2	-0.9
Medication: Paracetamol	0.8	1.3	2.7	-0.9	0.5	0.7	1.1	1.6	1.6
Forced vital capacity (FVC), Best measure	0.8	2.9	8.1	1.7	0.5	-0.8	2.8	-0.2	2.4
Wheeze or whistling in the chest in last year	0.8	1.4	2.7	-1.2	-1.0	0.9	-1.6	-0.6	-1.5
Neck or shoulder pain in last month	0.8	1.2	2.2	0.8	-1.0	1.0	-1.5	-0.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.7	0.3	-0.5	-0.9	-0.9	-1.6	-1.1
Commuting to job workplace: Walk	0.8	0.8	2.2	-0.0	0.2	-0.1	1.1	1.5	1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	1.6	0.1	1.3	1.2	0.4	0.6
Risk taking	0.8	1.1	2.8	-0.7	0.3	0.7	1.7	0.7	1.6
Heart disease (siblings)	0.8	1.0	4.3	-0.7	-0.2	2.1	-0.8	0.1	-0.6
Age at First Birth	0.7	1.0	1.8	-0.0	1.3	0.3	1.0	1.3	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.9	0.3	0.5	1.7	1.0	1.0	1.0
Hand grip strength (right)	0.7	1.8	4.7	0.1	0.8	0.5	2.2	1.0	2.0
Medication: Simvastatin	0.7	1.0	2.5	-0.6	-0.3	1.0	-1.6	-0.6	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	-1.6	0.8	1.5	-0.3	1.0	0.0
Mouth/teeth dental problems: Dentures	0.7	1.1	3.5	1.0	-0.7	-1.9	-0.2	-1.2	-0.6
Asthma	0.7	1.4	3.1	-0.9	-0.7	-1.0	-1.8	-1.0	-1.4
Prospective memory result	0.7	0.8	2.0	0.2	0.5	-0.7	1.4	0.3	1.4
Impedance of arm (left)	0.7	3.4	7.8	0.5	-2.3	0.8	-1.7	-2.8	-1.8
Pulse wave reflection index	0.7	0.8	2.8	-1.7	1.2	0.2	-0.1	0.4	0.6
Blood clot in the leg (DVT)	0.7	1.0	5.1	2.3	0.1	-0.5	0.6	0.2	0.0
Suffer from ‘nerves’	0.7	1.1	2.4	-0.2	1.6	0.6	1.2	1.3	0.9
Miserableness	0.7	1.1	1.8	-1.2	1.3	1.0	0.5	1.3	0.9
Medication: Paracetamol	0.7	1.1	2.6	-0.7	0.3	0.2	1.2	1.4	1.6
Illnesses of father: High blood pressure	0.7	0.9	2.5	-0.7	1.1	-0.6	0.4	1.6	0.9
Diastolic blood pressure, automated reading	0.7	2.1	6.8	-0.3	-0.6	-2.6	-1.2	-1.5	-1.2
Supplements: Calcium	0.7	0.8	2.1	-0.1	0.9	0.9	0.7	1.4	0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.5	2.1	0.1	-0.5	0.6	0.1	0.1
Rheumatoid Arthritis	0.6	0.8	1.6	0.2	-0.8	-0.5	-1.3	-1.0	-1.0
Heel T-Score	0.6	4.7	7.4	2.7	-1.7	-1.9	-1.9	-2.4	-2.2
Angina	0.6	0.8	2.2	0.2	-0.7	1.5	-0.7	-0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.7	-0.6	0.5	1.9	0.0	0.5	0.2
Sitting height	0.6	4.1	12.0	-0.2	0.1	0.3	3.1	1.7	3.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.7	1.2	0.0	-1.6	0.0	0.3	-0.1
Trunk fat mass	0.6	2.5	6.4	-0.5	-1.4	2.5	1.6	0.3	2.0
Falls in the last year	0.6	0.9	2.5	0.1	0.9	-0.1	0.9	1.6	1.1
Pulse rate	0.6	1.0	3.0	-1.7	0.0	1.3	-0.8	0.8	-0.4
Leg fat percentage (right)	0.6	2.0	5.2	-0.5	-2.3	1.4	-1.2	-1.5	-0.9
Exposure to tobacco smoke outside home	0.6	0.9	2.6	1.6	0.9	-0.9	0.7	0.4	0.5
Worry too long after embarrassment	0.6	0.9	3.0	-1.5	0.3	1.7	-0.6	0.2	-0.3
Age at first live birth	0.6	1.1	2.9	-0.9	-0.0	1.7	1.2	0.9	1.1
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.2	0.3	0.5	1.3	0.9	1.2
Angina (self-reported)	0.6	0.8	1.6	0.1	-0.6	1.3	-0.9	-0.8	-1.2
Family relationship satisfaction	0.6	0.8	1.6	0.3	-0.3	-0.9	-1.1	-1.0	-1.2
Illnesses of father: Heart disease	0.6	0.8	1.5	-1.2	-0.7	-0.3	-1.0	-1.1	-0.8
Smoking status: Previous	0.6	0.9	1.7	1.3	-0.8	-1.0	0.8	0.7	0.9
Diabetes diagnosed by doctor	0.6	1.0	4.3	-0.1	-0.2	2.1	-0.9	0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	3.2	-1.8	-0.7	0.6	-0.3	-0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	2.6	-1.6	-1.1	0.3	0.1	-0.0	0.2
Mineral and other dietary supplements	0.6	0.8	1.2	0.7	-0.3	-1.1	-1.1	-0.8	-1.0
Commuting to job workplace: Public transport	0.6	0.7	2.0	0.1	0.6	1.4	-0.5	1.0	-0.5
Medication: Blood pressure	0.6	1.2	2.3	0.0	1.3	-0.3	1.5	1.2	1.3
Medication: Bendroflumethiazide	0.6	0.9	1.6	-1.2	-0.8	-1.2	-0.9	-0.6	-0.6
Leg fat percentage (left)	0.6	2.0	5.3	-1.1	-2.3	1.3	-1.2	-1.4	-0.8
Age started oral contraceptive pill	0.6	0.7	1.5	0.0	1.0	-1.2	0.7	0.7	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.2	-0.7	1.5	-0.2	0.8	0.7	0.7
Pain experienced in last month	0.6	1.0	1.5	1.2	1.2	0.1	1.1	1.0	0.9
Pack years of smoking	0.6	0.8	2.4	-0.8	1.6	1.1	0.2	0.6	0.4
Prostate Cancer	0.5	0.7	1.6	-0.5	1.2	-1.0	-1.0	-0.0	-0.7
Bipolar Disorder (2011)	0.5	0.5	1.3	0.0	0.0	0.0	0.5	1.2	1.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	0.4	0.9	0.0	1.1	0.8	1.3
Crohns Disease (2012)	0.5	0.8	2.2	-1.5	1.4	0.2	-0.5	0.6	0.1
Lung FVC	0.5	2.7	6.6	0.9	2.6	-1.1	2.2	0.5	1.6
Average weekly spirits intake	0.5	0.6	1.8	1.3	-0.8	-0.5	0.6	-0.5	0.3
Diabetes (father)	0.5	0.6	1.3	-0.8	0.9	-0.1	0.9	0.6	1.1
Trunk fat percentage	0.5	2.0	6.4	-0.5	-2.1	2.5	0.3	-0.6	0.7
Taking other prescription medications	0.5	0.8	1.5	-0.6	-1.2	0.6	-0.9	-1.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	1.1	0.0	-1.0	0.8	-0.1	0.8
Waist circumference	0.5	1.9	4.5	-1.1	-0.8	0.8	2.0	0.6	2.1
Had menopause	0.5	0.7	1.6	0.9	-0.3	0.2	1.3	0.5	1.1
Qualifications: None of the above	0.5	1.1	2.1	0.1	-1.0	0.8	-1.4	-0.9	-1.4
Allergy	0.5	1.0	4.0	-0.5	-0.4	2.0	0.7	0.7	0.9
Hip circumference	0.5	2.4	6.0	-0.5	-0.5	1.2	2.4	0.8	2.5
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.6	1.6	1.0	-0.1	0.9	1.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.6	0.3	0.5	-0.8	2.1	-0.1	2.0
Arm fat mass (right)	0.5	2.1	5.0	-1.2	-0.4	2.2	1.4	1.1	1.8
Loud music exposure frequency	0.5	0.6	1.7	0.2	-0.8	-0.4	-0.6	-1.3	-0.8
Glaucoma (self-reported)	0.5	0.6	1.5	-0.5	-0.8	1.2	-0.7	-0.6	-0.7
Body fat percentage	0.5	1.9	5.0	-0.7	-2.2	2.2	-0.3	-0.9	0.0
Comparative body size at age 10	0.5	1.3	3.1	-1.8	-0.6	1.7	-0.3	1.0	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-0.1	0.2	1.2	-0.8	-0.8	-1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	0.8	-0.3	-0.8	-1.1	-1.1	-1.3
Whole body fat mass	0.5	1.9	4.8	-0.7	-1.3	2.2	1.3	0.2	1.6
Had major operations	0.5	0.6	1.4	-0.8	-0.4	1.2	0.6	0.6	0.8
Leg pain on walking	0.5	0.6	0.9	-0.7	1.0	0.9	0.5	0.8	0.6
Medication: Aspirin	0.5	0.6	1.1	-0.0	-0.7	0.7	-1.0	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.9	1.4	-1.1	-0.5	0.8	-1.3	0.6
Osteoporosis (self-reported)	0.5	0.6	3.1	-1.8	-0.4	0.3	-0.3	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.1	1.4	-0.9	-1.5	-0.3	-0.8	-0.3
Cardiovascular Disease	0.4	1.4	7.2	-2.7	0.3	0.4	-0.7	0.6	-0.1
Systolic blood pressure, automated reading	0.4	1.1	1.9	1.1	1.2	-0.7	1.4	0.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.3	-1.1	0.7	0.8	0.5	1.0	0.8
Had other major operations	0.4	0.4	1.2	0.7	-0.1	-0.2	1.1	-0.2	0.9
Financial difficulties in last 2 years	0.4	0.5	1.8	-0.3	0.3	1.3	-0.7	0.4	-0.6
Diabetes (self-reported)	0.4	0.6	2.7	-0.1	-0.6	1.6	-0.7	0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.2	-0.7	1.5	-0.6	-0.0	-0.0	-0.1
Illnesses of siblings	0.4	0.6	2.0	1.4	0.1	-1.1	0.2	-0.5	0.3
Arm fat percentage (right)	0.4	1.5	4.8	-1.7	-0.9	2.2	-0.0	0.4	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-1.0	-0.7	0.6	0.7	0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-1.3	0.3	1.3	-0.3	0.3	-0.2
Headache pain in last month	0.4	0.7	1.5	-0.0	1.2	0.9	0.6	1.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.2	-0.5	1.1	-0.7	-0.3	-1.0
Shortness of breath walking on level ground	0.4	0.5	0.9	0.2	-0.4	-0.9	-0.9	-0.5	-0.9
Medication: Allopurinol	0.4	0.5	1.3	1.1	0.3	1.2	0.0	0.7	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	-0.4	0.1	0.9	-0.9	-0.3	-0.9
Knee pain experienced in last month	0.4	0.7	1.8	0.0	-0.5	-0.5	1.1	0.6	1.3
Arm fat percentage (left)	0.4	1.5	4.9	-1.5	-1.4	2.2	-0.2	0.0	0.2
Ever had bowel cancer screening	0.4	0.4	1.4	0.2	-0.3	-1.2	0.7	-0.5	0.6
Medication: Aspirin	0.4	0.5	0.8	-0.1	-0.7	0.8	-0.8	-0.8	-0.9
Arm fat mass (left)	0.4	1.7	4.4	-1.0	-0.5	2.1	1.2	0.8	1.5
Wears glasses or contact lenses	0.4	0.4	0.9	-0.9	-0.2	0.9	0.3	0.6	0.6
Ever taken oral contraceptive pill	0.4	0.4	0.7	-0.6	-0.5	0.8	-0.8	-0.1	-0.7
Average weekly beer plus cider intake	0.4	0.6	2.2	1.5	-0.1	-1.2	0.2	-0.1	-0.2
Irritability	0.4	0.8	2.6	-1.6	-1.0	0.4	-0.5	-0.6	-0.4
Ever depressed for a whole week	0.4	0.5	2.0	0.4	-0.3	-1.4	-0.3	-0.8	-0.3
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	1.0	0.2	-0.2	1.1	-0.3	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	0.9	0.8	-0.9	0.2	0.2	0.1
Crohns Disease (2017)	0.3	0.7	1.9	0.5	0.3	-1.0	-1.4	-0.4	-1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	-0.9	0.6	-0.9	-1.2	0.2	-0.5
Ulcerative Colitis (UC)	0.3	0.7	1.8	-1.3	0.9	-0.8	-0.6	0.6	0.0
Major Depression (MDD)	0.3	0.4	0.8	0.7	-0.2	0.9	0.7	0.7	0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.7	0.6	-1.3	0.0	-0.2	-0.3	-0.2
HDL Cholesterol	0.3	0.5	1.4	1.2	1.0	0.0	-0.4	0.3	-0.2
Lupus	0.3	0.5	1.8	-0.2	-1.3	0.3	-0.5	-0.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	1.0	0.0	0.0	0.7	0.4	0.3
Blood Eosinophil Count	0.3	2.0	5.9	-0.1	-2.4	-1.1	-1.4	-1.6	-0.8
Systolic Blood Pressure	0.3	1.4	2.4	0.1	1.5	-1.4	1.1	1.2	1.1
Chronotype (morning person)	0.3	0.6	1.3	1.2	0.2	0.7	0.5	0.9	1.0
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-0.2	0.3	-0.3	0.5	0.8	1.0
Age when periods started (menarche)	0.3	0.8	2.0	-0.4	-1.3	1.4	-0.6	-0.6	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.9	-0.1	0.4	-1.7	-0.6	-0.5	-0.6
Medication: Atenolol	0.3	0.4	1.3	0.6	0.1	-0.3	1.1	0.2	0.8
Body mass index (BMI)	0.3	1.3	3.3	-1.3	-0.2	1.8	0.6	1.2	0.9
Number of incorrect matches in round	0.3	0.5	0.8	-0.7	-0.5	0.7	-0.5	-0.6	-0.9
Hearing difficulty/problems with background noise	0.3	0.4	1.8	-0.4	0.3	-1.4	0.3	0.6	0.4
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	-0.6	-1.0	-0.1	-0.4	-0.7	-0.2
Heart attack	0.3	0.3	0.9	0.9	0.1	1.0	-0.2	0.1	-0.5
Fluid intelligence score	0.3	0.5	1.9	0.2	-0.8	-1.4	-0.6	-0.3	-0.4
Impedance of arm (right)	0.3	1.6	3.5	-0.2	-1.4	1.1	-1.2	-1.9	-1.2
Father’s age at death	0.3	0.4	0.7	-0.6	0.5	0.6	0.5	0.8	0.6
Noisy workplace	0.3	0.4	1.0	1.0	-0.7	-0.1	-0.3	-0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	0.1	-0.8	-0.8	-0.5	-0.7	-0.5
Birth weight	0.3	0.7	1.7	1.3	0.1	-0.3	1.2	0.3	1.1
Qualifications: College or University degree	0.3	0.8	3.5	-1.9	-0.0	0.6	0.6	0.6	0.5
Medication: Blood pressure	0.3	0.4	1.2	-1.1	-0.1	0.8	-0.6	-0.2	-0.6
Medication: Ibuprofen	0.3	0.3	1.4	-0.1	-1.2	0.1	0.5	-0.2	0.5
Leg fat mass (right)	0.3	1.3	2.9	-0.9	-1.0	1.7	1.1	0.3	1.5
Overall health rating	0.3	0.7	1.8	-0.7	0.9	0.1	0.6	1.3	0.9
Chest pain or discomfort	0.3	0.5	1.2	-0.1	0.3	0.8	-0.9	-0.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.6	-0.4	0.5	-1.3	0.3	0.1	0.5
Illnesses of siblings: Diabetes	0.3	0.3	1.6	-0.2	1.2	-0.1	0.4	0.5	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-1.1	-0.1	0.8	0.1	-0.1	-0.1
Osteoarthritis (self-reported)	0.3	0.3	0.9	-0.5	-0.4	0.3	0.6	0.5	1.0
Medication: Gliclazide	0.3	0.3	0.9	1.0	0.0	0.5	-0.6	0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.7	-0.0	-0.3	1.3	0.5	0.3	0.1
Number of operations (self-reported)	0.3	0.4	1.0	-0.8	-0.8	1.0	-0.2	-0.1	0.2
Unable to work because of sickness or disability	0.3	0.4	0.9	-0.0	0.3	-0.3	-0.8	-0.9	-0.8
Commuting to job workplace: Cycle	0.3	0.3	1.1	-1.1	0.3	-0.1	0.6	0.5	0.3
Leg fat mass (left)	0.3	1.3	2.4	-1.1	-1.0	1.6	1.0	0.3	1.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.3	0.8	-0.7	0.1	0.4	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.5	-0.3	-0.6	-0.1	-0.8	0.1
Breast Cancer	0.2	0.4	1.1	1.0	0.2	0.7	0.8	0.4	-0.1
BMI	0.2	1.4	3.9	-2.0	-1.2	1.5	0.0	0.6	0.5
Respiratory disease	0.2	0.5	0.8	-0.8	-0.4	-0.9	-0.7	-0.6	-0.4
Hair Pigment	0.2	6.0	21.7	0.9	4.7	-0.9	2.1	2.2	1.8
Hearing difficulty/problems: Yes	0.2	0.2	0.5	-0.0	-0.4	-0.3	0.7	0.5	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.4	-0.0	0.4	0.8	0.5	0.6
Medication: Co-codamol	0.2	0.2	0.5	-0.7	0.1	0.6	-0.6	0.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	-0.6	0.4	0.7	0.4	0.5	0.3
Past tobacco smoking	0.2	0.4	1.7	-0.5	1.3	0.5	-0.0	-0.1	-0.1
Time employed in main current job	0.2	0.2	0.8	0.1	-0.9	0.3	-0.2	-0.5	-0.3
Length of working week for main job	0.2	0.2	0.6	-0.4	-0.1	-0.8	-0.5	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.7	0.5	0.3	0.8	0.0	0.2
Gout (self-reported)	0.2	0.2	0.6	0.8	-0.2	0.8	0.3	0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.5	-0.1	0.4	1.0	0.4	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	0.9	0.3	0.4	-0.0	0.1	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	1.2	-0.3	-0.9	-0.0	-0.3	-0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.3	0.1	-0.1	-0.0	-0.7	-0.3
Triglycerides	0.1	0.1	0.5	0.2	-0.7	0.0	-0.1	-0.3	0.0
Ulcerative Colitis	0.1	0.2	0.4	-0.7	0.6	0.2	-0.5	-0.1	-0.4
Blood Platelet Count	0.1	1.7	4.9	-0.3	1.3	-2.2	0.8	1.4	0.9
Waist Hip Ratio (WHR)	0.1	0.6	1.0	-0.2	-0.9	-0.8	1.0	-1.0	0.5
Allergy or Eczema	0.1	0.4	1.1	-0.8	0.7	-1.0	-0.3	0.3	-0.3
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.4	-0.3	0.5	0.4	-0.0	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	0.2	-0.1	0.9	-0.5	-0.0	-0.6
Number of treatments/medications taken	0.1	0.2	1.1	-0.4	-0.1	1.1	-0.1	0.3	0.1
Medication for hormone replacement therapy	0.1	0.1	0.5	-0.0	-0.1	-0.7	0.1	-0.1	-0.1
Severe depression (siblings)	0.1	0.1	0.4	-0.1	-0.5	0.1	0.1	-0.6	-0.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.1	-0.4	-0.2	0.3	0.2	0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.1	-0.4	0.2	0.4	0.2	0.5
High blood pressure (mother)	0.1	0.2	0.5	-0.3	-0.5	0.7	0.3	0.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.2	0.7	-0.1	-0.1	0.3	0.1
Medication: Ramipril	0.1	0.2	0.7	-0.2	0.5	-0.8	0.1	0.2	0.0
Tense / ‘highly strung’	0.1	0.1	0.4	-0.6	0.5	-0.1	0.3	0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.3	0.2	1.2	-0.3	0.0	0.5	-0.0
Medication: Omeprazole	0.1	0.1	0.5	-0.5	0.7	0.2	0.1	0.2	-0.1
Pulse rate, automated reading	0.1	0.4	1.4	-0.4	1.2	0.6	0.1	0.9	0.2
Alcohol intake frequency.	0.1	0.1	0.3	0.4	0.1	0.4	0.3	0.3	0.5
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.3	0.5	0.8	-0.4	0.1	-0.4
Medication for cholesterol	0.1	0.1	0.3	-0.3	-0.2	0.5	-0.2	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.1	0.6	-0.8	0.4	-0.5	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	0.7	-0.2	0.0	0.2	0.2	0.0
Ever smoked	0.1	0.1	0.7	0.0	-0.8	-0.1	-0.0	0.0	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.6	-0.2	0.2	-0.2	0.2	0.8	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.4	-0.6	-0.0	-0.4	-0.5	-0.2
Cholesterol lowering medication	0.1	0.2	0.8	-0.1	0.2	0.3	-0.9	-0.0	-0.6
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.3	-0.6	0.1	-0.7	-0.3	-0.1
Tanning	0.0	0.5	0.9	-0.6	-0.8	-0.7	-0.9	-0.7	-0.6
Qualifications: CSEs or equivalent	0.0	0.0	0.2	0.2	0.1	0.1	-0.4	-0.2	-0.0
High blood pressure	0.0	0.1	0.3	-0.1	0.3	-0.5	0.1	0.1	-0.0
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	-0.4	0.1	0.2	0.3	-0.1	0.1
Hypertension (Self-reported)	0.0	0.1	0.2	-0.1	0.4	-0.1	0.4	0.5	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.2	-0.4	-0.0	-0.4	0.1	-0.1	0.2
Hearing aid user	0.0	0.0	0.0	0.2	0.0	-0.1	-0.2	-0.2	-0.1

Hub : Genes

CARNS1

Models

Trait associations