TWAS hub - CBLB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2900	0.0910	1.5e-03	0.113	NA	0.107	NA	0.104	3.3e-04	NA	4.7e-04	NA	5.6e-04
2	GTEx	Muscle Skeletal	0.1176	0.0361	9.8e-05	0.012	NA	0.031	NA	0.025	2.0e-02	NA	4.6e-04	NA	1.5e-03
3	GTEx	Testis	0.2670	0.0650	5.7e-06	0.222	NA	0.160	NA	0.184	3.3e-10	NA	1.4e-07	NA	1.4e-08
4	GTEx	Thyroid	0.0970	0.0350	6.8e-04	0.019	NA	0.020	NA	0.022	1.3e-02	NA	1.1e-02	NA	8.2e-03
5	METSIM	Adipose	0.0617	0.0201	8.5e-05	0.049	0.033	0.028	0.046	0.057	6.5e-08	7.8e-06	4.5e-05	1.9e-07	5.6e-09
6	YFS	Blood	0.1601	0.0241	0.0e+00	0.220	0.198	0.217	0.219	0.219	2.8e-70	1.4e-62	2.4e-69	5.6e-70	4.0e-70
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0451	0.0231	1.1e-03	0.003	0.020	0.001	NA	0.002	1.3e-01	2.1e-03	2.4e-01	NA	1.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hypothyroidism (self reported)	9.2	21.2	33.3	4.9	0.7	-3.9	5.2	5.0	4.9	-5.8
Hypothyroidism/myxoedema (self-reported)	8.0	15.6	25.1	4.7	0.3	-3.8	4.7	3.4	3.6	-5.0
Medication: Levothyroxine sodium	5.4	9.1	13.5	3.4	0.2	-2.7	3.4	3.2	3.2	-3.7
Depression (self-reported)	3.2	3.9	6.1	1.9	-1.5	-2.0	2.4	1.8	1.3	-2.5
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.8	10.0	1.0	2.6	-1.4	2.2	2.6	1.7	-3.2
Fasting Glucose	2.9	3.5	7.5	1.3	0.8	-0.8	1.3	2.4	2.5	-2.7
Rheumatoid Arthritis	2.8	3.9	11.6	0.9	1.4	-0.5	1.1	2.6	2.1	-3.4
Medication: Atenolol	2.6	3.3	8.5	-2.1	0.2	2.9	-2.5	-0.4	-0.6	1.8
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	8.7	1.7	-1.4	-3.0	2.8	-0.4	-0.6	-1.1
Father’s age at death	2.5	3.4	10.0	-2.1	0.8	2.5	-3.2	-0.1	0.2	1.5
Lung cancer (father)	2.5	3.0	8.3	1.9	-0.3	-1.9	2.9	1.7	1.2	-1.0
Worry too long after embarrassment	2.5	4.1	7.0	2.4	-0.7	-2.5	2.6	1.2	1.1	-2.6
Emphysema/chronic bronchitis	2.5	2.8	4.8	-1.7	0.4	1.1	-1.8	-2.2	-2.1	1.7
Medication: Simvastatin	2.4	3.5	5.2	2.2	-0.8	-1.9	2.2	1.9	1.4	-2.3
Smoking status: Previous	2.4	3.6	7.4	-2.6	2.7	1.9	-1.7	-1.4	-1.1	1.3
Blood clot in the leg (DVT)	2.3	3.0	7.6	1.7	-1.4	-2.8	2.6	-0.2	-0.3	-1.4
Number of self-reported non-cancer illnesses	2.3	4.0	9.0	1.3	1.3	-1.5	2.4	2.2	1.7	-3.0
Risk taking	2.3	3.4	6.5	-2.5	-0.1	2.0	-2.3	-1.3	-1.0	2.3
Illnesses of mother	2.1	2.5	4.4	-1.1	-1.3	0.8	-1.7	-2.0	-2.1	1.7
Ever smoked	2.1	3.7	9.6	-3.0	3.1	2.5	-1.3	-0.0	-0.0	0.2
Fractured/broken bones in last 5 years	2.1	2.7	4.9	-1.5	1.9	2.1	-2.2	0.7	1.7	0.6
Primary Biliary Cirrhosis	2.0	2.8	6.1	-1.7	-0.7	1.1	-1.3	-2.5	-2.4	1.2
Past tobacco smoking	2.0	3.7	11.2	2.7	-3.3	-2.1	1.4	0.7	0.7	-0.5
Schizophrenia (2018)	1.9	3.9	7.9	-2.8	0.1	2.4	-2.8	0.8	1.4	1.8
Number of treatments/medications taken	1.9	3.4	6.5	1.7	0.8	-1.3	1.7	2.6	1.7	-2.4
Taking other prescription medications	1.9	3.0	5.5	0.7	1.8	-0.6	1.8	2.3	1.7	-2.3
Number of full brothers	1.9	2.4	4.9	1.8	-2.2	-2.1	1.7	-0.8	-0.7	-0.0
Financial situation satisfaction	1.9	2.3	8.6	0.6	0.5	-0.3	0.9	1.8	1.7	-2.9
Reaction Time	1.8	3.5	6.1	2.5	-0.4	-2.0	2.2	1.6	1.8	-1.8
Age at First Birth	1.8	2.7	5.4	-0.8	-0.9	0.5	-1.1	-2.3	-2.3	2.3
Overall health rating	1.8	3.8	8.5	1.2	1.4	-1.7	2.7	2.0	0.9	-2.9
High blood pressure (mother)	1.7	2.4	4.0	1.0	1.1	-1.2	1.8	1.7	2.0	-1.7
Number of live births	1.7	2.4	5.3	2.2	-2.0	-2.3	1.3	0.5	0.4	-0.9
Ever highly irritable/argumentative for 2 days	1.7	2.1	5.1	-2.3	1.8	1.6	-1.5	-0.3	0.0	1.1
Pain experienced in last month	1.7	2.8	7.9	-1.6	0.5	2.3	-1.5	-0.1	-1.1	2.8
Basal cell carcinoma (self-reported)	1.7	2.0	6.6	-0.5	-1.3	-0.8	0.1	-2.1	-2.6	0.6
Bipolar Disorder or Schizophrenia	1.6	3.8	9.3	-3.0	0.6	2.6	-2.8	0.2	1.0	1.2
Crohns Disease (2017)	1.6	3.5	9.2	-0.9	1.9	1.2	-0.4	3.0	2.8	-1.2
Triglycerides	1.6	2.6	4.2	2.0	0.5	-1.3	1.9	1.4	1.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.1	1.5	0.1	-1.9	2.0	0.9	0.7	-1.7
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	7.0	-1.1	2.6	1.6	-0.6	1.7	1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	7.0	-2.6	0.1	2.0	-1.5	-0.2	-0.4	1.1
Medication: Paracetamol	1.6	2.6	6.4	1.5	0.5	-1.5	1.4	1.4	1.7	-2.5
Number of full sisters	1.6	2.0	4.0	1.7	-0.4	-1.8	2.0	0.7	0.6	-1.6
Age at last live birth	1.6	2.3	4.1	1.7	-1.7	-2.0	2.0	-0.9	-1.0	-0.8
Ovarian Cancer	1.5	2.0	4.0	1.4	-1.1	-1.1	0.3	-2.0	-1.8	1.5
Stomach or abdominal pain in last month	1.5	1.9	5.2	0.1	0.2	-0.7	1.1	2.0	1.4	-2.3
Qualifications: None of the above	1.5	3.3	8.6	1.7	-2.9	-2.3	1.4	-1.2	-1.2	1.3
Allergy	1.5	3.6	7.7	-2.5	-0.0	2.8	-2.0	0.9	0.4	2.4
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.4	-1.4	1.8	1.8	-1.4	0.8	-0.0	0.9
Illnesses of father: None of the above (group 1)	1.5	1.8	4.0	1.9	-2.0	-1.4	1.0	-0.7	-1.2	0.1
Angina	1.4	1.8	4.5	-0.8	-1.4	-0.0	-1.1	-1.3	-2.1	1.6
Pack years adult smoking proportion	1.4	2.2	3.6	1.6	-0.2	-1.3	1.2	1.9	1.9	-1.6
Number of incorrect matches in round	1.4	2.4	9.8	1.5	-3.1	-1.6	1.0	0.0	0.5	-0.8
Trunk fat-free mass	1.4	8.0	17.7	1.4	1.9	-0.8	2.1	3.8	4.2	-3.6
Trunk predicted mass	1.4	7.9	17.5	1.4	1.8	-0.8	2.1	3.8	4.2	-3.6
Angina (self-reported)	1.4	1.8	4.8	-0.8	-1.4	-0.0	-1.0	-1.4	-2.2	1.6
High cholesterol (Self-reported)	1.4	2.6	6.9	1.7	-0.0	-0.5	0.9	2.6	1.8	-1.9
Crohns Disease (2012)	1.3	2.1	5.3	-1.2	0.6	1.4	-1.1	2.0	2.3	-0.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.9	-1.1	1.6	1.1	-0.5	-1.0	-1.7	1.1
Hair/balding pattern: Pattern 2	1.3	1.6	2.6	-1.2	1.3	1.0	-1.1	-1.6	-1.1	1.4
Arm fat-free mass (right)	1.3	6.6	12.5	1.8	1.0	-1.5	2.5	3.2	3.5	-3.3
Illnesses of father: Heart disease	1.3	1.8	4.6	-2.1	2.1	1.6	-0.9	-0.0	-0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.3	-0.5	-0.7	0.3	-0.9	-1.8	-1.3	1.7
Smoking status: Current	1.3	2.1	5.6	1.1	0.3	-0.7	1.2	2.4	2.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	7.3	0.4	-1.1	0.1	-0.9	-2.7	-2.6	1.8
Medication: Paracetamol	1.3	2.0	4.2	1.3	0.9	-1.1	1.0	1.4	1.8	-2.0
Arm fat-free mass (left)	1.3	6.6	11.3	1.8	0.8	-1.6	2.6	3.2	3.4	-3.4
Schizophrenia (2014)	1.2	2.6	5.4	-2.2	0.1	1.9	-2.3	0.8	1.4	1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.4	1.6	-0.3	-2.1	1.0	-0.7	-0.2	-1.6
Medication: Cholesterol lowering	1.2	1.8	4.6	1.5	-0.3	-1.0	1.3	2.2	1.3	-1.2
Breastfed as a baby	1.2	1.5	4.2	1.9	-0.8	-2.1	1.3	-0.3	0.2	0.2
Arm predicted mass (right)	1.2	6.0	11.2	1.8	0.8	-1.5	2.4	3.1	3.4	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.4	0.3	1.3	-0.3	0.6	1.3	1.4	-2.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.1	0.7	0.3	-1.6	2.0	0.7	0.4	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.3	1.3	-1.2	-1.5	1.1	0.6	0.8	-1.3
Arm predicted mass (left)	1.2	6.3	10.0	2.1	0.6	-1.9	2.7	3.0	3.2	-3.1
Bipolar Disorder (2011)	1.1	1.1	2.5	-1.0	-0.8	0.4	-0.9	-1.6	-1.1	1.2
Body Mass Index (BMI) (2010)	1.1	1.5	4.4	-1.2	2.1	1.6	-1.1	0.5	0.2	-0.5
Mean Putamen Volume	1.1	1.2	3.1	0.1	-0.4	-0.2	-0.8	-1.8	-1.7	1.3
Lupus	1.1	1.6	3.5	-1.1	1.2	1.7	-1.6	-0.1	-0.0	1.9
Diabetes (mother)	1.1	1.4	4.0	0.7	0.7	-0.7	1.3	1.3	0.9	-2.0
Current tobacco smoking	1.1	1.8	5.2	0.9	0.0	-0.7	1.0	2.3	2.0	-1.1
Financial difficulties in last 2 years	1.1	1.5	3.3	1.4	-0.7	-1.8	1.3	0.3	-0.0	-1.8
Diabetes (self-reported)	1.1	1.7	4.3	0.8	1.3	-0.1	0.4	2.0	2.1	-0.8
Length of working week for main job	1.1	1.2	2.4	-0.7	0.4	0.8	-1.1	-1.2	-1.6	1.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.0	-1.3	-0.4	0.9	-1.4	-2.2	-1.3	1.0
Medication: Amlodipine	1.1	1.6	4.5	0.5	2.1	0.2	0.7	1.4	1.2	-1.6
Number of children fathered	1.1	1.2	4.8	-1.0	0.5	0.5	-1.0	-0.8	-0.5	2.2
Shortness of breath walking on level ground	1.1	1.3	2.7	-1.6	1.6	1.3	-1.3	0.1	-0.4	0.1
Medication: Ibuprofen	1.1	1.3	3.0	1.2	0.3	-1.5	1.7	0.9	0.6	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.7	1.0	-1.2	-1.5	1.7	-0.4	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.5	1.8	-0.6	-2.2	2.4	-0.3	-0.9	-1.2
Whole body fat-free mass	1.1	6.3	14.1	1.3	1.6	-0.7	1.9	3.5	3.8	-3.1
Back pain experienced in last month	1.1	1.7	3.5	0.9	-1.3	-1.9	1.4	-0.9	-0.4	-1.6
Whole body water mass	1.1	6.1	13.8	1.3	1.6	-0.8	1.9	3.4	3.7	-3.0
Basal metabolic rate	1.1	6.3	12.9	1.4	1.6	-0.9	2.1	3.4	3.6	-3.2
Myopia	1.1	1.6	5.8	-1.0	2.4	0.8	-0.4	1.1	1.3	-0.9
Heart disease (siblings)	1.1	1.4	3.2	-1.8	0.5	1.5	-1.6	0.4	0.4	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.2	6.7	-2.6	1.3	2.4	-2.1	-0.7	-0.5	1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	5.2	-1.1	-0.3	0.9	-1.3	-0.1	-0.2	2.3
Alzheimer’s Disease (in father)	1.0	1.1	3.4	1.9	-0.9	-1.4	0.8	0.6	0.6	-0.6
Blood Red Count	1.0	10.0	18.7	-3.6	2.7	4.3	-4.2	-1.9	-0.8	3.0
Diabetes (father)	1.0	1.2	3.6	-0.3	1.0	0.9	-0.2	1.4	1.9	-0.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	5.4	2.3	0.2	-2.1	1.1	-0.8	0.1	-1.7
Fluid intelligence score	1.0	2.0	4.8	-0.8	2.0	1.4	-0.7	2.2	1.4	-0.5
Weight	1.0	5.0	8.4	1.3	1.3	-1.3	2.2	2.9	2.9	-2.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.3	-0.6	1.0	1.3	-1.8	-0.6	0.2	1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	4.1	-0.8	0.2	1.4	-1.5	-1.2	-1.1	2.0
Neck or shoulder pain in last month	1.0	1.5	5.7	0.3	0.8	0.0	0.2	1.1	1.6	-2.4
Leg fat mass (right)	1.0	4.0	6.4	2.0	0.5	-2.1	2.5	1.9	1.8	-2.4
Ever taken oral contraceptive pill	1.0	1.1	2.8	0.1	0.4	-0.1	-0.4	-1.7	-1.5	1.5
Commuting to job workplace: Public transport	1.0	1.2	2.9	-1.2	1.7	1.2	-0.8	0.7	0.9	0.8
Medication: Atorvastatin	1.0	1.2	2.5	-1.5	1.6	1.6	-0.9	0.3	0.1	-0.5
Irritable Bowel Disease (IBD)	0.9	2.2	4.3	-1.1	1.6	1.3	-0.4	2.1	1.9	-1.5
Cardiovascular Disease	0.9	2.9	5.3	1.7	-0.4	-1.3	1.6	1.8	2.1	-2.3
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.8	1.2	0.6	-1.0	1.3	0.3	0.3	-1.3
High blood pressure	0.9	2.6	5.3	0.9	0.3	-0.5	1.3	2.3	2.3	-2.3
Hip circumference	0.9	3.7	6.0	1.5	0.9	-1.5	2.5	2.2	2.0	-2.4
Pulse wave Arterial Stiffness index	0.9	1.1	1.8	1.2	-0.7	-0.5	1.0	1.1	1.1	-1.4
Loud music exposure frequency	0.9	1.0	1.7	-1.3	0.6	1.0	-1.3	-1.3	-0.7	-0.0
Pulse rate, automated reading	0.9	2.8	4.9	2.1	1.0	-1.3	1.9	1.7	1.0	-2.2
Illnesses of father: High blood pressure	0.9	1.2	2.6	-1.6	1.1	1.5	-1.3	-0.2	0.0	0.1
Pack years of smoking	0.9	1.3	2.9	1.2	-0.1	-0.9	0.8	1.6	1.7	-1.0
Leg fat mass (left)	0.9	3.5	5.5	1.8	0.5	-1.8	2.4	2.0	1.8	-2.2
Alzheimer’s Disease (including proxy)	0.8	1.2	5.3	2.3	-0.6	-1.4	0.1	-0.7	0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.7	-1.7	2.2	1.6	-1.1	1.4	0.8	-0.2
HDL Cholesterol	0.8	1.4	2.9	0.9	-1.7	-1.6	1.5	0.6	0.3	-0.9
Lung FVC	0.8	4.1	10.1	0.7	-1.4	-0.5	-1.1	-3.2	-3.0	2.3
Leg fat-free mass (left)	0.8	4.0	8.6	0.9	1.5	-0.6	1.6	2.8	2.9	-2.4
Maternal smoking around birth	0.8	1.1	2.7	-1.1	0.8	1.2	-1.6	0.2	0.8	1.0
Relative age voice broke	0.8	1.2	2.9	1.7	-0.9	-1.4	1.5	0.1	-0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.8	-1.4	-0.8	0.8	-0.9	-1.2	-0.4	1.0
Qualifications: CSEs or equivalent	0.8	1.0	2.7	-0.7	1.6	0.2	-0.0	-1.1	-1.4	-0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	-1.6	1.0	0.9	-0.4	-0.6	-0.6	1.0
Leg predicted mass (left)	0.8	4.0	8.4	1.1	1.4	-0.7	1.7	2.8	2.9	-2.3
Medication: Ramipril	0.8	1.1	1.9	1.1	0.4	-0.9	1.4	1.3	1.0	-0.7
Standing height	0.8	7.8	19.0	1.8	1.5	-1.3	3.1	3.1	3.1	-4.4
Headache pain in last month	0.8	1.3	2.9	1.4	-0.5	-1.6	1.1	-0.5	0.1	-1.7
Mean time to correctly identify matches	0.8	1.5	2.6	1.6	-0.2	-1.1	1.5	1.3	1.4	-1.0
Hypertension (Self-reported)	0.8	2.2	5.4	0.2	0.5	0.2	0.6	2.3	2.3	-2.0
Leg fat-free mass (right)	0.8	4.0	9.4	0.7	1.4	-0.3	1.5	2.9	3.1	-2.3
Osteoporosis (self-reported)	0.8	1.0	2.1	0.1	1.4	0.7	-0.4	0.8	1.3	-1.2
Leg predicted mass (right)	0.8	4.1	9.5	0.7	1.5	-0.3	1.4	3.0	3.1	-2.3
Age started oral contraceptive pill	0.8	1.0	2.6	0.5	-0.7	-0.8	0.0	-1.6	-1.4	1.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.0	-0.8	0.1	0.7	-1.4	-2.0	-2.0	2.0
Neuroticism (Nagel 2018)	0.7	1.7	4.8	0.7	0.6	-1.6	2.2	0.8	0.5	-1.7
Alzheimer’s Disease (in mother)	0.7	0.9	3.2	1.8	0.0	-1.1	0.3	-1.2	0.4	0.2
Chronotype (morning person)	0.7	1.6	4.5	1.4	0.3	0.3	1.2	2.1	1.6	-0.7
Waist circumference	0.7	2.7	4.3	1.6	0.3	-1.7	2.1	1.6	1.5	-2.0
Alcohol usually taken with meals	0.7	1.2	3.3	-0.3	0.9	0.5	0.3	1.1	1.8	-1.6
Happiness	0.7	0.8	1.9	-0.4	0.4	-0.8	0.9	-1.2	-1.4	-0.7
Prospective memory result	0.7	0.9	2.3	-0.2	-1.5	-0.5	0.1	-1.3	-0.8	1.1
Birth weight	0.7	1.5	3.0	1.3	-1.7	-1.7	1.5	0.7	0.6	-0.4
Health satisfaction	0.7	1.0	2.3	-1.5	1.5	0.9	-0.6	-0.0	0.3	-1.0
Medication: Allopurinol	0.7	0.9	2.2	-1.0	0.2	1.5	-1.2	-0.6	-0.4	1.1
Long-standing illness, disability or infirmity	0.7	1.1	2.5	-0.1	1.6	0.0	0.9	1.5	0.8	-1.3
Friendships satisfaction	0.7	0.8	5.1	-0.2	2.3	0.1	0.5	-0.1	0.5	-0.3
Qualifications: nursing, teaching	0.7	1.0	2.6	-1.3	0.5	1.5	-1.6	-0.6	-0.3	0.4
Arm fat mass (left)	0.7	2.7	4.8	1.0	1.2	-1.0	1.7	2.1	1.9	-2.2
Average weekly champagne plus white wine intake	0.7	0.9	2.4	0.3	-0.1	-0.1	1.2	1.6	1.4	-0.9
Miserableness	0.7	1.2	4.8	0.3	0.9	-1.0	1.3	0.5	0.4	-2.2
Bipolar Disorder (2018)	0.6	0.9	2.1	-1.4	1.0	1.1	-1.0	-0.7	-0.2	-0.5
Breast Cancer	0.6	1.5	4.2	-0.9	2.1	0.7	0.1	0.7	0.9	-1.9
Blood Eosinophil Count	0.6	4.5	8.2	1.5	2.9	-0.3	1.5	2.4	2.8	-2.3
Heel T-Score	0.6	4.6	8.9	-0.9	-1.4	0.9	-2.3	-3.0	-2.7	2.6
Allergy or Eczema	0.6	1.6	5.0	2.2	0.1	-1.8	0.6	-1.5	-0.5	-0.4
Ever had hysterectomy (womb removed)	0.6	0.6	1.2	-0.7	1.1	1.1	-0.8	0.0	0.4	-0.9
Average weekly fortified wine intake	0.6	0.7	2.8	-0.7	0.1	0.2	-0.6	-0.6	-0.8	1.7
Had other major operations	0.6	0.7	3.1	0.4	-1.8	-1.1	0.7	-0.1	-0.2	-0.2
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	1.4	-0.4	-1.7	1.3	0.1	-0.1	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	2.1	-0.4	1.4	0.4	0.0	1.0	0.9	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-1.1	-1.1	0.5	-0.5	-1.2	-0.6	0.7
Pulse wave peak to peak time	0.6	0.8	1.2	-1.1	0.8	0.4	-0.8	-0.9	-0.9	1.0
Whole body fat mass	0.6	2.5	4.2	1.4	1.0	-1.4	2.1	1.7	1.3	-1.9
Alcohol intake frequency.	0.6	1.3	3.7	1.8	-0.1	-1.9	1.5	0.3	-0.0	-0.3
Family relationship satisfaction	0.6	0.8	4.6	-0.1	2.2	0.1	0.6	0.1	0.2	-0.5
Ever had bowel cancer screening	0.6	0.7	1.3	-1.1	0.4	1.1	-1.0	-0.5	-1.1	0.1
Diabetes diagnosed by doctor	0.6	1.0	2.6	0.6	1.0	0.0	0.3	1.6	1.6	-0.6
Guilty feelings	0.6	0.8	2.2	-0.3	-0.1	0.0	-0.0	1.5	1.5	-1.2
Wears glasses or contact lenses	0.6	0.7	2.2	-0.4	0.5	0.3	-0.6	-0.5	-1.2	1.5
Medication: Lisinopril	0.6	0.7	1.9	-1.0	0.1	1.4	-1.1	-0.3	-0.4	0.7
Average weekly beer plus cider intake	0.6	0.9	3.8	-0.4	1.9	1.0	-0.4	0.5	0.9	0.2
Prostate Cancer	0.5	0.6	1.4	-0.9	0.7	1.2	-1.0	0.3	-0.0	0.8
Blood Platelet Count	0.5	5.3	11.0	-2.8	3.3	3.3	-2.2	0.7	0.2	1.6
Blood White Count	0.5	3.4	8.6	-0.7	2.9	1.2	0.0	2.4	2.4	-1.2
Smoking Status	0.5	1.3	4.1	-1.5	2.0	1.0	-0.9	0.3	0.7	0.5
Relative age of first facial hair	0.5	1.0	2.6	0.4	-0.7	-1.2	1.6	-0.8	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	0.5	-0.4	-0.5	0.4	-1.3	-1.1	0.6
Age when periods started (menarche)	0.5	1.3	3.0	0.2	-0.5	-1.1	1.4	-1.4	-1.7	-0.8
Trunk fat mass	0.5	2.3	4.3	1.4	0.8	-1.3	2.1	1.6	1.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.1	0.7	0.6	-0.7	1.4	1.2	0.2	-0.9
Had menopause	0.5	0.6	1.5	0.6	-1.2	-0.6	0.1	-0.6	-0.6	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.7	0.7	-1.6	-1.5	1.2	0.7	0.3	-0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	0.2	0.0	-1.0	1.2	-0.2	0.3	-1.4
Alcohol intake versus 10 years previously	0.5	0.7	1.4	1.2	0.9	-1.1	0.6	0.8	0.4	-0.5
Falls in the last year	0.5	0.6	1.5	0.4	1.2	-0.6	0.5	0.7	0.9	-0.9
Pulse rate	0.5	0.8	3.1	-0.7	1.7	0.7	-0.4	0.2	-0.1	-1.2
Arm fat mass (right)	0.5	2.1	3.4	1.1	1.0	-1.2	1.7	1.7	1.4	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.5	0.3	-0.2	-1.0	1.1	0.5	0.7	-1.6
Leg fat percentage (right)	0.5	1.7	3.2	1.6	0.0	-1.8	1.8	0.9	0.7	-1.4
Comparative body size at age 10	0.5	1.4	3.6	-0.8	1.0	0.8	-0.7	1.9	1.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-0.9	1.0	0.7	-0.3	0.8	1.1	-0.8
Age at first live birth	0.5	0.9	3.2	0.7	-0.3	-1.0	1.8	0.1	0.1	-1.2
Qualifications: College or University degree	0.5	1.5	2.5	-0.9	1.1	1.6	-0.1	1.5	1.5	-1.3
Medication: Omeprazole	0.5	0.6	1.0	-0.8	0.4	0.8	-0.8	0.9	1.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.4	0.4	-0.6	0.9	0.6	0.9	-1.2
Had major operations	0.5	0.5	1.5	0.2	1.2	-0.6	0.6	0.2	0.2	-1.2
Average weekly red wine intake	0.5	0.8	2.3	-0.2	-1.1	0.3	-0.3	0.9	1.0	-1.5
Commuting to job workplace: Walk	0.5	0.6	2.2	-0.1	-1.5	0.2	-0.6	0.4	0.4	1.0
Medication: Gliclazide	0.5	0.6	1.2	-1.1	0.6	1.0	-0.4	-0.6	-0.6	0.9
Hearing aid user	0.5	0.6	1.7	0.8	0.8	-0.4	0.3	0.7	0.8	-1.3
Medication: Bendroflumethiazide	0.5	0.7	2.6	-0.4	-0.1	0.5	-0.4	1.6	1.3	-0.2
Leg fat percentage (left)	0.5	1.6	3.0	1.6	-0.1	-1.6	1.7	1.0	0.8	-1.2
Irritability	0.5	0.9	3.5	0.1	1.9	-0.5	1.1	0.0	-0.1	-1.0
Unable to work because of sickness or disability	0.5	0.7	1.7	-0.1	0.8	-0.2	1.1	1.3	0.5	-0.9
Cholesterol lowering medication	0.5	0.8	2.2	0.4	0.3	-0.1	0.2	1.1	1.3	-1.5
Depressed Affect (Nagel 2018)	0.4	0.7	1.5	-0.7	0.7	-0.9	1.0	-1.0	-1.2	0.1
Major Depression (MDD)	0.4	0.5	2.2	0.3	0.7	-0.1	0.0	0.8	1.5	0.3
Hand grip strength (left)	0.4	1.1	2.5	1.2	-1.6	-1.0	0.4	-1.3	-0.9	0.1
Average weekly spirits intake	0.4	0.5	1.1	0.2	-0.2	-0.4	0.9	1.1	1.0	-0.6
Hearing difficulty/problems: Yes	0.4	0.5	1.2	-1.0	1.1	0.7	-0.7	0.0	0.7	-0.3
Medication: Co-codamol	0.4	0.5	1.3	0.1	-1.1	-0.4	0.1	-0.5	-0.9	0.9
Severe depression (siblings)	0.4	0.4	1.3	-0.2	0.8	-0.3	0.2	-1.2	-0.8	0.5
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.7	1.1	1.1	-0.8	-0.6	-0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	0.4	0.8	-0.7	0.8	1.1	0.7	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.4	0.6	-0.7	0.9	0.7	0.8	-0.8
Multivitamins +/- minerals	0.4	0.6	1.4	-0.7	-0.2	0.7	-1.2	-0.7	-1.0	0.2
Supplements: Glucosamine	0.4	0.6	1.4	-0.4	1.1	0.6	-1.2	0.0	0.2	0.9
Time employed in main current job	0.4	0.5	1.2	0.8	0.7	-1.0	1.1	-0.1	-0.2	-0.3
Asthma	0.4	0.8	1.8	0.8	1.3	-1.0	1.0	-0.4	-0.7	-0.8
Medication: Lansoprazole	0.4	0.5	1.6	-1.1	1.2	0.6	0.1	0.3	-0.1	-0.5
Exposure to tobacco smoke at home	0.4	0.5	1.1	-0.1	-1.1	-0.8	0.7	-0.6	-0.7	-0.4
Glaucoma (self-reported)	0.4	0.4	1.9	-0.2	-1.4	-0.1	-0.1	-0.4	-0.6	0.7
High blood pressure (siblings)	0.4	0.6	1.5	0.6	-0.0	-0.7	1.2	1.0	0.5	-0.4
Medication: Blood pressure	0.4	0.8	2.6	0.6	0.9	-0.2	0.8	1.6	0.7	-0.6
Migraine (self-reported)	0.4	0.5	1.7	0.3	0.1	-0.9	1.3	0.0	0.3	-1.1
Medication: Seretide 50 evohaler	0.4	0.4	1.0	-0.8	0.2	0.7	-1.0	-0.5	-0.5	0.4
Chest pain or discomfort	0.4	0.6	1.9	-0.1	1.1	-0.1	0.3	-0.3	-0.8	-1.4
Leg pain on walking	0.4	0.5	1.3	-1.1	1.0	0.6	-0.7	-0.6	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	0.2	-1.2	-0.0	0.3	-0.5	-0.9	0.6
Asthma (self-reported)	0.4	0.7	1.8	0.5	1.3	-0.8	0.9	-0.5	-0.9	-0.8
Mother’s age at death	0.4	0.4	0.8	-0.1	0.5	-0.3	0.7	0.9	0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	0.5	-0.3	-1.3	1.1	-0.5	-0.2	0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.7	0.0	-1.3	-0.7	0.6	0.4	-0.2	-0.1
HbA1C	0.3	0.3	0.6	-0.3	0.5	0.7	-0.8	-0.6	-0.3	0.3
LDL Cholesterol	0.3	0.4	0.9	0.8	-0.6	-0.4	0.6	0.6	0.9	-0.1
Respiratory disease	0.3	0.6	1.5	-0.8	1.2	-0.3	0.1	-0.8	-1.2	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.8	0.6	-0.6	0.4	1.3	1.1	-0.1
Sensitivity / hurt feelings	0.3	0.5	0.9	0.4	-0.2	-0.7	1.0	0.9	0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.0	0.3	-0.5	1.0	0.6	-0.3	-1.1
Systolic blood pressure, automated reading	0.3	0.8	1.7	1.2	-1.3	-0.7	0.4	-1.2	-0.4	0.4
Medication for hormone replacement therapy	0.3	0.4	0.7	0.8	-0.9	-0.9	0.3	-0.4	-0.5	0.1
Vitamin and mineral supplements	0.3	0.4	1.0	0.4	-0.2	-0.5	0.9	0.7	1.0	0.0
Hand grip strength (right)	0.3	0.8	2.1	1.4	-1.4	-0.8	0.5	-0.1	0.4	-0.6
Fed-up feelings	0.3	0.5	2.5	-1.0	1.6	0.3	0.1	0.2	-0.0	-0.1
Body mass index (BMI)	0.3	1.3	2.7	0.6	0.7	-0.8	1.1	1.6	1.6	-1.1
Impedance of leg (left)	0.3	1.3	2.2	1.3	-1.3	-1.0	0.9	-1.2	-1.5	-0.4
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.7	0.1	0.7	-0.3	0.9	0.9	-0.4
Impedance of arm (right)	0.3	1.2	4.9	-0.1	-0.3	0.3	-0.1	-1.5	-2.2	0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.0	-1.0	0.5	-0.4	0.2	-0.1	1.1
Pulse wave reflection index	0.3	0.3	1.6	0.4	-1.3	0.0	0.0	0.7	0.5	-0.0
Gout (self-reported)	0.3	0.4	1.2	-0.3	-0.0	1.1	-1.0	0.4	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.8	0.9	-0.2	-0.0	0.5	0.8	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	3.1	-0.2	1.8	-0.5	0.5	-0.3	-0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.4	-1.2	0.6	0.6	-0.4	0.1	-0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	-0.2	0.6	-0.7	0.4	-0.6	-1.2	0.2
Supplements: Vitamin C	0.3	0.4	0.9	-0.3	0.9	0.8	-0.8	0.1	0.2	-0.7
Knee pain experienced in last month	0.3	0.5	1.0	1.0	-0.5	-0.6	-1.0	0.0	0.4	1.0
Loneliness, isolation	0.3	0.4	1.9	-0.8	1.4	-0.1	0.2	0.1	0.1	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.0	0.1	0.1	-0.2	1.0	0.7	0.8
Medication: Blood pressure	0.3	0.5	1.7	-0.7	-0.1	1.3	-1.0	0.3	0.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.7	0.5	0.2	-0.5	0.8	0.6	0.9
Alcohol drinker status: Never	0.3	0.4	1.0	1.0	-0.8	-0.8	0.4	-0.1	0.1	0.5
Ever depressed for a whole week	0.3	0.4	0.9	-0.4	0.6	-0.5	0.9	-0.4	0.2	-0.9
Supplements: Calcium	0.3	0.3	0.7	-0.5	0.4	0.7	-0.5	0.8	0.7	0.0
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.6	0.7	0.7	0.0	0.5	0.3	-1.1
Neuroticism (2016)	0.2	0.3	0.6	-0.1	0.3	0.4	0.3	-0.5	-0.8	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.2	0.9	0.5	-0.3	-0.4	0.2	-0.3
Ulcerative Colitis	0.2	0.2	0.6	-0.7	-0.1	0.8	-0.6	-0.2	-0.4	0.2
BMI	0.2	1.2	2.8	0.6	0.7	-0.6	1.0	1.7	1.6	-0.9
Height	0.2	4.6	6.9	2.5	1.2	-1.6	2.6	2.1	2.1	-2.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.6	1.0	-0.0	-0.1	-0.4	-0.8	0.1
Impedance of leg (right)	0.2	1.2	2.0	1.1	-0.9	-1.2	1.0	-1.2	-1.4	-0.7
Trunk fat percentage	0.2	0.7	2.2	0.9	0.3	-1.0	1.5	0.6	0.0	-0.8
Sitting height	0.2	1.4	3.0	0.4	1.3	0.1	0.9	1.3	1.5	-1.7
Mouth/teeth dental problems	0.2	0.3	0.8	0.3	0.1	0.4	-0.6	-0.9	-0.8	0.5
Illnesses of siblings	0.2	0.2	0.4	-0.6	-0.0	0.6	-0.7	-0.5	-0.2	-0.5
Arm fat percentage (right)	0.2	0.7	1.3	0.8	0.5	-0.9	1.1	0.9	0.5	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	1.0	-0.3	-0.4	0.2	-1.3	-0.7	-0.7
Impedance of arm (left)	0.2	0.9	3.5	-0.6	0.1	0.7	-0.4	-1.2	-1.9	0.4
Birth weight of first child	0.2	0.4	0.7	0.8	-0.9	-0.6	0.5	0.4	0.8	-0.2
Peak expiratory flow (PEF)	0.2	0.6	1.7	1.3	-0.4	-0.9	0.8	-0.6	-0.1	-0.6
Body fat percentage	0.2	0.9	2.3	1.1	0.4	-1.2	1.5	0.7	0.3	-0.9
Eye problems/disorders: None of the above	0.2	0.3	0.5	-0.5	0.5	0.7	-0.6	0.1	0.4	0.6
Heart disease (mother)	0.2	0.2	0.8	-0.4	0.0	0.2	0.3	0.9	0.4	-0.1
Comparative height size at age 10	0.2	1.3	3.7	0.7	1.2	-0.1	1.0	1.1	1.2	-1.9
Suffer from ‘nerves’	0.2	0.3	1.2	-0.1	0.1	-0.5	1.1	0.5	-0.1	-0.5
Medication: Aspirin	0.2	0.2	0.6	0.2	-0.7	0.1	-0.3	0.3	0.5	0.8
Arm fat percentage (left)	0.2	0.7	1.1	0.7	0.6	-0.8	1.1	0.9	0.6	-1.0
Mood swings	0.2	0.4	1.2	-0.7	0.8	-0.0	0.5	-0.2	-0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	-0.6	0.7	0.5	-0.8	0.1	0.4	0.9
Medication for cholesterol	0.2	0.3	0.8	-0.0	0.3	-0.5	0.6	-0.6	-0.9	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.7	0.8	0.3	0.0	0.2	-0.0	-0.4
Medication: Aspirin	0.2	0.3	0.9	-0.0	-0.0	0.5	-0.5	0.8	0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.4	-0.1	0.7	-0.0	-0.1	0.1	0.5	-1.2
Number of operations (self-reported)	0.2	0.3	0.8	-0.9	0.2	0.4	-0.7	-0.2	0.5	0.7
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.2	-0.7	-0.5	0.4	-0.6	-0.9	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.9	-0.9	0.0	0.5	-0.5	0.3	0.3	-0.2
Impedance of whole body	0.2	1.0	3.9	0.4	-0.7	-0.2	0.3	-1.4	-2.0	0.1
Depression (Nagel 2018)	0.1	0.2	0.8	-0.4	0.9	0.0	-0.1	0.2	0.1	0.3
Worry (Nagel 2018)	0.1	0.3	0.9	-0.0	0.3	-0.4	0.9	0.3	0.4	-0.8
Waist Hip Ratio (WHR)	0.1	0.3	0.8	0.7	-0.9	-0.7	0.3	-0.4	-0.2	-0.1
Systolic Blood Pressure	0.1	0.4	1.1	0.7	-0.7	-0.3	0.5	-0.5	0.3	-1.1
Lung FEV1/FVC ratio	0.1	0.3	0.5	0.6	-0.3	0.4	0.1	0.7	0.7	-0.6
Neuroticism	0.1	0.3	0.7	-0.8	0.3	-0.3	0.6	-0.4	-0.6	0.3
Hair Pigment	0.1	1.9	3.4	-0.6	1.4	1.8	-1.3	1.9	1.5	0.6
Tanning	0.1	1.2	3.5	0.3	-0.4	-1.0	0.1	-1.9	-1.7	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.1	-0.3	-0.4	-0.2
Supplements: Zinc	0.1	0.1	0.3	-0.1	0.1	0.0	-0.5	-0.3	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	-0.3	-0.5	-0.1	0.0	0.6	0.1	0.0
Nervous feelings	0.1	0.2	0.4	0.4	0.3	-0.6	0.7	-0.3	-0.4	-0.0
Forced vital capacity (FVC)	0.1	0.4	1.0	0.8	0.3	-0.4	0.1	-1.0	-0.5	-0.7
Heart attack	0.1	0.1	0.6	0.0	0.1	-0.3	0.8	0.3	-0.2	0.1
Pain all over the body in last month	0.1	0.1	0.3	0.4	-0.1	-0.0	-0.5	-0.1	-0.3	0.6
Neuroticism score	0.1	0.2	0.4	-0.5	0.3	-0.4	0.6	-0.1	-0.4	-0.6
Worrier / anxious feelings	0.1	0.1	0.6	-0.1	-0.7	-0.1	-0.0	-0.4	-0.2	-0.1
Noisy workplace	0.1	0.2	0.7	0.1	0.8	-0.1	0.4	0.2	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.0	-0.2	0.6	-0.4	0.6	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.1	0.3	-0.1	-0.2	-0.2	-1.0	-0.7	-0.2
Tense / ‘highly strung’	0.1	0.1	0.3	0.4	0.0	-0.2	-0.1	-0.5	-0.5	0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.5	0.5	0.7	-0.7	0.3	0.5	0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.8	0.9	0.1	-0.8	0.4	-0.5	-0.3	-0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.7	-0.2	0.1	-0.2	0.8	-0.1	-0.4	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.0	0.4	0.4	-0.1	0.5	0.5	-0.4
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	-0.5	-0.3	0.6	-0.6	-0.3	-0.3
Breast cancer (self-reported)	0.1	0.1	0.2	-0.3	-0.2	0.4	0.0	0.3	0.2	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	1.1	1.1	-0.7	-0.4	0.3	-0.8	-0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.7	0.1	0.3	-0.3	0.8	0.3	-0.2	0.0
Alcohol drinker status: Previous	0.1	0.2	0.4	0.4	0.7	-0.1	0.2	0.3	0.2	-0.5
Medication: Metformin	0.0	0.1	0.3	-0.0	0.2	-0.3	0.5	0.2	0.1	-0.0
Eye problems/disorders: Glaucoma	0.0	0.1	0.2	0.1	-0.4	0.2	-0.2	0.1	0.2	0.4

Hub : Genes

CBLB

Models

Trait associations