Hub : Genes

CBR3-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.172	0.0520	1.0e-04	-0.001	NA	-0.003	NA	-0.003	4.4e-01	NA	8.3e-01	NA	8.8e-01
2	GTEx	Adipose Visceral Omentum	0.238	0.0820	1.0e-03	-0.004	NA	-0.005	NA	-0.005	6.3e-01	NA	8.8e-01	NA	7.0e-01
3	GTEx	Artery Aorta	0.116	0.0510	9.9e-03	-0.002	NA	0.030	NA	0.025	4.5e-01	NA	8.9e-03	NA	1.4e-02
4	GTEx	Artery Tibial	0.120	0.0408	5.4e-04	0.014	NA	0.013	NA	0.010	2.7e-02	NA	3.0e-02	NA	5.1e-02
5	GTEx	Colon Transverse	0.259	0.0750	1.0e-04	0.071	NA	0.098	NA	0.103	2.8e-04	NA	2.0e-05	NA	1.4e-05
6	GTEx	Esophagus Mucosa	0.305	0.0610	1.8e-09	0.279	NA	0.216	NA	0.276	7.1e-19	NA	1.7e-14	NA	1.3e-18
7	GTEx	Nerve Tibial	0.129	0.0455	1.4e-03	0.097	NA	0.063	NA	0.088	2.2e-07	NA	2.8e-05	NA	8.5e-07
8	GTEx	Pancreas	0.268	0.0860	6.5e-04	0.162	NA	0.100	NA	0.148	2.3e-07	NA	5.3e-05	NA	8.5e-07
9	GTEx	Prostate	0.422	0.0960	1.3e-04	0.132	NA	0.201	NA	0.226	3.4e-04	NA	9.0e-06	NA	2.2e-06
10	GTEx	Skin Sun Exposed Lower leg	0.212	0.0510	1.1e-06	0.118	NA	0.114	NA	0.124	5.2e-10	NA	1.1e-09	NA	2.0e-10
11	GTEx	Stomach	0.274	0.0740	1.5e-04	0.112	NA	0.070	NA	0.129	5.0e-06	NA	3.1e-04	NA	1.0e-06
12	GTEx	Testis	0.489	0.0800	2.7e-07	0.247	NA	0.255	NA	0.250	2.4e-11	NA	1.1e-11	NA	1.8e-11
13	GTEx	Thyroid	0.307	0.0530	1.4e-13	0.274	NA	0.248	NA	0.261	3.9e-21	NA	5.4e-19	NA	4.6e-20

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.9	1.5	3.3	0.5	0.9	1.1	-0.1	1.5	-1.2	1.8	1.4	1.4	-0.8	1.3	1.4	1.3
Bipolar Disorder or Schizophrenia	3.9	9.6	16.0	-0.5	-0.8	0.6	-3.0	3.9	-4.0	1.2	4.0	3.9	-3.7	3.3	3.6	3.6
Depressed Affect (Nagel 2018)	0.6	1.3	2.4	0.3	-1.6	0.2	1.2	-1.2	1.2	-0.6	-1.5	-1.4	1.2	-1.2	-1.0	-1.2
Depression (Nagel 2018)	1.4	2.1	4.2	2.0	-0.5	0.5	1.8	-1.7	1.1	0.5	-1.1	-1.8	0.6	-2.1	-1.7	-2.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.4	-0.4	-0.1	1.5	0.8	0.5	-0.7	1.5	0.9	0.7	-0.6	0.5	0.6	0.4
Neuroticism (Nagel 2018)	0.4	0.9	5.5	-0.6	-2.4	-1.1	0.2	0.1	0.5	-1.5	-0.8	-0.2	0.6	0.3	0.5	0.3
Schizophrenia (2018)	4.9	10.2	17.3	-1.0	-1.7	-0.1	-3.8	3.8	-4.2	0.1	4.0	3.9	-4.2	3.2	3.5	3.6
Schizophrenia vs Biploar Disorder	0.8	1.1	5.7	-0.7	-1.8	-0.8	-2.4	0.3	-0.5	-1.4	0.3	0.4	-0.4	0.5	0.5	0.5
Worry (Nagel 2018)	0.5	1.0	2.9	-1.3	-1.7	-1.2	-0.7	0.5	0.3	-1.7	-0.4	0.4	0.5	1.1	1.0	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	5.5	2.3	-0.1	1.1	-0.4	0.4	-0.6	0.9	0.7	0.6	-1.1	-0.0	0.3	0.4
Alzheimer’s Disease (in father)	0.8	0.8	2.6	-0.7	0.7	0.2	0.8	1.4	0.0	0.2	-0.1	1.1	0.4	1.1	1.6	1.4
Alzheimer’s Disease (including proxy)	0.7	0.9	2.5	1.6	-0.7	0.7	-0.5	1.3	-0.5	0.8	0.5	1.4	-0.4	0.6	1.3	1.3
Crohns Disease (2017)	0.2	0.5	2.3	-0.1	1.1	1.5	-0.1	0.6	0.2	-0.6	-0.2	0.5	0.5	0.7	0.7	0.7
Irritable Bowel Disease (IBD)	0.2	0.6	2.2	1.5	1.1	1.5	-0.0	0.6	-0.1	0.3	0.1	0.5	-0.2	0.6	0.4	0.5
Ulcerative Colitis (UC)	0.6	1.0	5.3	2.3	1.1	1.2	0.2	0.5	-0.7	1.4	0.8	0.5	-1.2	0.5	0.1	0.2
Major Depression (MDD)	0.3	0.4	0.7	-0.6	-0.4	-0.4	-0.8	0.9	-0.0	-0.5	0.0	0.8	0.4	0.6	0.7	0.9
Reaction Time	0.9	1.8	3.4	-1.1	-1.0	-0.1	0.3	1.8	-1.8	-0.3	1.5	1.7	-0.9	1.4	1.6	1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.6	-0.8	-1.1	0.2	0.1	0.8	-1.0	0.9	1.3	1.0	-1.0	0.5	0.9	0.7
Breast Cancer	0.5	1.3	2.1	-0.1	-0.5	-1.1	1.0	-1.4	1.4	-0.8	-1.3	-1.4	0.6	-1.3	-1.4	-1.4
Ovarian Cancer	0.6	0.8	3.3	1.8	0.4	-0.0	0.4	-0.9	0.6	-0.9	-0.9	-1.1	0.2	-0.9	-0.8	-1.0
Prostate Cancer	3.1	4.3	9.7	-1.9	-1.2	-1.7	-1.2	2.6	-1.6	-1.7	1.3	2.4	-1.0	2.9	3.1	2.9
Age at First Birth	0.8	1.1	2.7	0.8	0.4	-1.1	0.0	-1.7	1.1	-0.3	-0.9	-1.3	0.5	-1.2	-1.3	-1.6
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.5	-0.2	-0.5	-0.5	0.6	-0.4	-0.6	0.2	0.4	-0.0	0.3	0.8	0.8
Body Mass Index (BMI) (2010)	0.6	0.8	2.8	1.0	0.5	0.9	0.4	-0.5	0.9	1.7	-0.6	-0.4	1.2	-0.8	-0.8	-0.7
Coronary Artery Disease (CAD)	0.7	0.9	1.8	-1.1	-0.5	-0.8	0.8	-0.8	1.3	-1.4	-1.4	-1.1	0.9	-0.4	-0.0	-0.7
Crohns Disease (2012)	0.6	0.9	5.1	0.5	2.3	1.1	1.0	0.9	-0.4	0.5	0.5	0.8	0.3	0.8	0.8	0.8
Mean Putamen Volume	0.4	0.5	2.6	0.7	0.3	-0.2	1.6	-0.2	0.9	-0.0	-0.9	-0.2	1.0	-0.4	-0.1	-0.1
Fasting Glucose	1.3	1.6	5.1	-0.5	1.0	0.1	2.0	-1.7	0.7	-0.4	-0.6	-1.8	2.2	-1.0	-1.1	-1.1
HbA1C	0.8	0.9	3.3	0.8	1.8	1.5	0.5	-1.1	0.7	0.3	-0.7	-1.1	0.1	-0.7	-0.7	-1.0
HDL Cholesterol	1.0	1.7	4.7	-2.2	-1.8	-0.4	0.3	1.2	-1.1	-1.6	0.8	0.7	-1.0	1.2	1.5	1.3
LDL Cholesterol	0.6	0.9	2.1	-0.1	0.9	-1.1	0.9	1.0	-0.3	-1.2	0.3	1.0	-0.4	1.4	1.5	1.1
Lupus	0.6	0.9	1.5	0.8	0.7	1.2	1.2	-0.6	-0.8	1.2	0.9	-0.2	-1.2	-1.2	-1.1	-0.7
Neuroticism (2016)	0.9	1.3	7.0	-1.1	-2.6	-1.5	-0.2	0.5	0.5	-1.8	-0.7	0.2	0.8	0.4	0.9	0.8
Primary Biliary Cirrhosis	1.0	1.4	3.7	0.3	-0.8	-0.2	-1.5	1.1	-1.9	1.2	1.9	1.2	-1.5	0.5	0.8	0.9
Rheumatoid Arthritis	0.2	0.3	0.8	0.5	-0.3	-0.7	0.7	0.7	-0.2	-0.1	0.1	0.7	0.3	0.5	0.9	0.9
Schizophrenia (2014)	6.6	14.5	24.9	-0.4	-1.9	0.1	-4.3	4.6	-5.0	0.4	4.9	4.8	-4.3	4.1	4.3	4.4
Triglycerides	0.5	0.8	3.9	-0.6	2.0	0.8	0.6	-0.5	1.1	0.6	-1.1	-0.6	1.2	-0.4	-0.6	-0.5
Type 2 Diabetes (T2D) (2012)	1.7	1.9	4.4	1.1	0.5	0.4	-0.3	-1.3	1.4	1.5	-1.2	-1.5	1.5	-2.0	-2.1	-1.7
Ulcerative Colitis	0.2	0.3	1.8	1.3	0.5	0.8	0.6	0.2	-0.3	0.8	0.2	0.1	-0.6	-0.1	-0.1	0.0
Blood Eosinophil Count	0.1	1.0	5.1	-0.0	1.3	1.0	0.5	0.7	-0.9	-2.3	0.6	0.6	-0.2	0.8	0.9	1.0
Blood Platelet Count	0.6	7.4	15.0	0.5	3.8	1.2	3.9	-2.8	3.3	-1.6	-3.5	-3.1	3.1	-1.7	-1.7	-2.5
Blood Red Count	0.2	1.6	8.9	-0.4	0.1	0.4	-0.7	-1.1	0.1	3.0	0.4	-0.9	0.6	-1.6	-2.0	-1.2
Blood White Count	1.1	7.9	13.9	-0.1	2.4	-0.2	2.5	-3.4	3.7	-0.5	-3.5	-3.3	3.6	-2.9	-3.2	-3.1
Heel T-Score	0.5	4.3	14.4	2.6	2.0	3.8	-2.0	-0.1	-1.6	3.8	1.6	-0.2	-1.5	-1.7	-1.1	-0.7
BMI	0.1	0.8	5.6	2.4	0.7	0.9	0.4	-0.5	-0.2	0.0	0.2	-0.4	-0.3	-1.3	-1.1	-0.7
Height	0.8	14.5	39.9	0.5	-3.3	0.8	-0.3	3.7	-6.1	3.0	6.3	4.2	-6.3	2.2	2.6	2.9
Waist Hip Ratio (WHR)	0.3	1.5	3.4	1.4	0.8	-0.0	0.8	-1.4	1.1	0.9	-0.7	-1.4	1.1	-1.7	-1.8	-1.7
Systolic Blood Pressure	0.3	1.6	6.8	-1.7	1.4	-1.2	2.6	-1.1	0.7	-0.8	-0.8	-1.0	0.2	-1.1	-1.0	-1.2
Smoking Status	1.5	3.7	8.2	1.7	1.5	1.0	0.7	-2.5	1.1	1.1	-1.1	-2.6	0.3	-2.8	-2.8	-2.9
Allergy or Eczema	1.7	4.5	11.3	-0.6	1.1	0.6	0.3	3.0	-1.9	-1.1	1.7	2.7	-1.8	2.9	3.4	3.1
Cardiovascular Disease	1.1	3.6	9.7	0.1	1.0	-0.7	3.1	-2.5	1.7	-0.3	-1.5	-2.2	1.2	-2.0	-2.6	-2.5
Hypothyroidism (self reported)	0.2	0.5	3.4	-0.1	-0.9	-0.8	-1.9	-0.6	0.4	-0.7	-0.3	-0.4	0.1	-0.6	-0.6	-0.6
Respiratory disease	0.7	1.6	4.2	-0.0	1.0	2.0	0.9	1.7	-0.8	0.6	1.0	1.6	0.4	1.6	1.7	1.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.3	-0.1	-0.2	0.4	1.7	-1.2	1.1	1.0	-0.9	-1.3	1.0	-1.8	-1.8	-1.5
Lung FEV1/FVC ratio	1.7	8.6	18.5	-1.3	1.7	1.1	3.5	-2.9	4.2	-0.3	-4.2	-3.3	4.3	-2.7	-2.4	-2.6
Lung FVC	0.5	2.6	8.6	1.5	1.0	2.1	-0.1	0.5	-2.2	2.9	2.5	0.7	-2.4	0.6	-0.1	0.0
Neuroticism	0.3	0.7	4.2	-0.7	-2.1	-1.2	0.3	0.1	0.5	-1.3	-0.7	-0.1	0.7	0.2	0.4	0.2
Chronotype (morning person)	0.3	0.7	3.2	-1.2	-0.2	-0.7	0.4	0.8	-0.1	-1.8	0.1	1.0	-0.1	0.9	0.9	1.0
Hair Pigment	0.1	1.5	6.1	-2.5	-1.7	-1.6	0.7	-0.6	0.3	-2.1	-0.8	-0.7	0.2	-0.7	-0.7	-0.3
Tanning	0.1	1.3	5.0	1.4	2.1	0.1	1.3	0.8	-0.7	2.2	1.1	0.8	-0.7	-0.1	0.2	0.3
Hand grip strength (left)	0.9	2.3	6.7	-0.0	-1.9	-0.1	-0.7	1.6	-2.2	0.4	2.0	1.7	-2.6	0.8	1.4	1.5
Number of treatments/medications taken	1.3	2.4	5.4	-0.4	0.2	-0.8	2.3	-1.9	1.4	-0.5	-1.3	-2.0	1.0	-2.0	-2.1	-2.1
Average weekly spirits intake	0.3	0.4	0.8	-0.1	-0.9	0.3	0.1	0.8	-0.7	0.9	0.8	0.8	-0.2	0.2	0.4	0.6
Sensitivity / hurt feelings	0.2	0.4	2.5	-0.4	-0.7	-1.6	1.1	0.2	0.1	-0.1	-0.0	-0.0	0.5	0.0	0.2	0.0
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.7	1.3	-1.7	-0.9	1.2	-1.8	0.9	0.5	-1.0	-2.0	-0.1	-2.2	-2.0	-2.2
Hearing difficulty/problems: Yes	0.2	0.4	1.4	0.3	-0.5	-0.6	-0.7	-0.5	0.5	-1.2	-0.6	-0.7	0.6	-0.2	-0.4	-0.5
Relative age of first facial hair	0.2	0.5	2.7	-0.8	0.1	-0.9	-0.2	-0.7	0.4	-1.7	-0.5	-0.5	-0.1	-0.2	-0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	2.0	-0.4	-0.2	-0.4	1.4	-0.4	0.4	-0.8	-0.3	-0.1	0.5	-0.2	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.1	1.3	1.2	2.0	2.3	-1.1	0.4	1.7	-0.2	-1.1	0.4	-1.3	-1.3	-1.3
Ever had hysterectomy (womb removed)	1.6	1.8	4.0	-1.9	-0.2	-0.2	0.9	-1.3	1.6	-1.7	-1.6	-1.3	2.0	-0.9	-1.0	-1.1
Systolic blood pressure, automated reading	0.5	1.5	5.9	0.0	0.8	0.7	2.4	-1.5	1.1	-0.1	-1.1	-1.3	1.1	-1.3	-1.2	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.3	-0.5	0.8	1.7	0.0	0.2	-1.2	1.8	1.3	0.3	-1.2	-0.1	-0.0	0.0
Angina	0.1	0.2	0.9	0.2	-0.3	-1.0	-0.8	-0.1	-0.1	-0.2	0.3	0.3	0.1	-0.0	-0.1	-0.0
Medication for hormone replacement therapy	0.6	0.6	2.0	0.6	1.0	0.9	-0.5	0.8	-0.8	1.4	0.9	0.7	-0.3	0.5	0.6	0.6
Vitamin and mineral supplements	0.6	0.9	3.2	1.8	0.7	0.5	0.3	-1.2	0.8	0.3	-0.6	-1.0	0.7	-0.8	-1.0	-1.2
Supplements: Zinc	0.3	0.3	0.9	-0.0	0.2	-0.8	-0.8	-0.1	-0.5	0.6	0.5	0.1	-1.0	-0.7	-0.5	-0.3
Medication: Co-codamol	0.2	0.3	0.9	-0.0	1.0	0.3	-0.5	-0.6	0.1	0.1	-0.4	-0.8	-0.2	-0.6	-0.6	-0.6
Medication: Metformin	0.4	0.6	2.2	-1.0	0.3	0.1	1.5	-0.6	0.6	-0.1	-0.6	-0.8	0.9	-0.9	-0.8	-0.7
Diabetes (father)	1.1	1.4	4.1	-1.3	1.1	-0.2	2.0	-0.9	1.3	-0.6	-1.5	-1.1	1.5	-1.1	-0.6	-0.8
Diabetes (mother)	0.3	0.4	1.0	-0.5	-0.1	0.2	-1.0	0.6	-0.8	0.6	0.8	0.6	-0.8	-0.2	0.3	0.5
Severe depression (siblings)	0.7	0.8	2.4	-1.5	-1.5	-1.3	-1.6	0.5	-0.5	0.2	0.4	0.3	-0.5	0.4	0.4	0.3
Pack years adult smoking proportion	1.1	1.7	2.7	0.8	-1.4	0.0	1.6	-1.4	1.4	-0.7	-1.5	-1.4	1.6	-1.4	-1.3	-1.2
Impedance of leg (right)	0.5	2.5	8.5	-1.3	0.4	-1.2	1.1	-0.8	2.5	-2.0	-2.7	-1.1	2.9	0.4	0.1	-0.2
Leg fat-free mass (left)	0.7	3.7	14.6	1.5	-1.2	0.8	-1.4	0.9	-3.3	1.4	3.4	1.4	-3.8	-0.5	-0.0	0.4
Trunk fat percentage	0.8	3.2	10.7	3.3	1.5	2.1	0.9	-1.9	0.1	0.7	0.1	-1.4	-0.2	-2.4	-2.5	-2.1
Hand grip strength (right)	1.8	4.8	15.9	-0.8	-2.5	0.6	-0.9	2.0	-3.3	1.3	3.2	2.1	-4.0	1.2	1.5	1.7
Townsend deprivation index at recruitment	0.7	1.0	3.2	-0.3	0.1	0.6	0.9	-1.3	0.6	0.5	-0.6	-1.2	0.2	-1.8	-1.7	-1.5
Current tobacco smoking	3.3	5.5	10.2	0.5	1.6	0.3	1.2	-3.1	2.6	0.3	-2.6	-3.2	2.2	-2.9	-3.2	-3.2
Average weekly fortified wine intake	0.2	0.2	0.6	0.0	0.3	0.6	0.1	-0.8	-0.1	0.4	0.0	-0.8	-0.2	-0.7	-0.7	-0.7
Maternal smoking around birth	0.6	0.9	2.5	0.7	-0.8	-1.3	0.7	-0.9	1.0	-1.6	-1.1	-0.6	0.3	-1.0	-0.5	-0.8
Fed-up feelings	1.2	2.2	8.1	-0.5	-2.8	-1.6	0.5	-1.4	1.5	-1.5	-1.7	-1.6	1.3	-1.2	-1.2	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	9.1	0.9	-1.8	-0.8	1.4	-2.5	1.4	0.3	-1.3	-2.3	0.3	-3.0	-2.6	-2.7
Relative age voice broke	1.5	2.3	8.2	-0.1	-0.7	-0.9	0.8	-1.4	2.1	-2.9	-2.3	-1.5	2.0	-0.7	-0.6	-0.9
Taking other prescription medications	0.1	0.2	1.2	0.8	0.3	0.2	1.1	0.0	0.2	0.1	-0.2	-0.2	0.8	-0.1	-0.1	-0.0
Age when periods started (menarche)	0.6	1.5	6.5	-0.7	1.1	-0.4	2.5	-1.3	0.5	1.1	-0.4	-1.2	0.2	-1.5	-1.6	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.0	-1.0	0.8	-0.1	-0.2	0.5	-0.3	-1.4	-0.0	0.4	0.2	0.5	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.1	0.3	1.1	1.1	-1.1	1.3	-1.9	1.0	2.0	1.4	-2.0	0.5	0.7	0.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	8.1	1.1	1.6	2.8	0.3	-0.6	0.3	1.3	-0.1	-0.7	0.6	-0.3	-0.5	-0.6
Qualifications: CSEs or equivalent	0.7	1.0	7.5	1.7	2.7	0.8	-0.7	-0.1	-0.3	0.8	0.3	0.0	-0.3	-0.3	-0.3	-0.2
Serious illness, injury or assault to yourself	0.8	1.0	3.3	0.5	-1.1	0.5	0.5	0.6	-1.5	1.6	1.4	0.6	-1.8	-0.3	0.0	0.3
High blood pressure	1.5	4.3	11.5	-0.2	1.4	0.2	3.4	-2.7	1.8	0.1	-1.5	-2.4	1.2	-2.4	-2.8	-2.8
Hayfever, allergic rhinitis or eczema	2.4	5.1	11.8	-0.5	1.2	0.5	0.6	3.1	-2.4	-0.1	2.3	3.0	-2.1	3.0	3.4	3.2
Multivitamins +/- minerals	1.5	1.9	4.1	-1.6	-0.3	-0.6	-1.2	2.0	-1.3	0.2	1.2	1.8	-0.7	1.6	1.8	2.0
Stomach or abdominal pain in last month	0.9	1.1	3.6	-1.5	-1.0	-1.5	-0.1	0.9	-0.1	-1.9	-0.1	0.7	-0.2	1.0	1.2	1.1
Supplements: Glucosamine	0.5	0.6	1.4	-0.5	-0.2	0.5	1.2	0.9	-0.7	0.9	0.8	1.0	-0.3	0.7	0.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	4.0	-1.1	0.8	0.5	2.0	0.6	0.1	-0.7	-0.0	0.8	0.2	1.2	1.0	0.8
Medication: Atenolol	4.6	5.8	12.0	1.5	-0.1	-0.8	2.4	-3.3	2.5	0.6	-2.1	-3.0	2.1	-3.0	-3.3	-3.5
Medication: Levothyroxine sodium	0.3	0.4	2.5	-1.0	-0.5	-0.9	-1.6	-0.5	-0.0	-0.6	0.0	-0.3	-0.4	-0.3	-0.4	-0.4
Sitting height	0.6	4.0	13.8	0.1	-1.9	-0.8	-2.0	1.7	-3.1	0.5	3.0	2.0	-3.7	0.9	1.2	1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.9	0.0	-1.1	-0.6	-0.9	0.9	-0.4	-1.4	0.1	0.6	-0.4	0.6	0.9	1.0
High blood pressure (mother)	0.3	0.4	2.0	1.4	0.7	-0.4	0.8	-0.2	-0.3	1.1	0.5	-0.1	-0.3	-0.2	-0.5	-0.4
Body mass index (BMI)	0.4	1.9	7.2	2.7	1.0	1.7	0.5	-1.2	-0.4	0.6	0.5	-0.9	-0.8	-2.0	-1.9	-1.5
Impedance of leg (left)	0.5	2.6	7.7	-1.1	0.2	-1.3	0.8	-1.0	2.6	-2.3	-2.8	-1.3	2.8	0.1	-0.1	-0.4
Leg predicted mass (left)	0.7	3.9	15.1	1.5	-1.2	0.8	-1.3	1.0	-3.4	1.5	3.5	1.5	-3.9	-0.4	0.0	0.4
Trunk fat mass	0.7	3.1	11.8	3.4	1.0	2.3	0.6	-1.4	-0.8	1.4	1.0	-0.9	-1.3	-2.4	-2.3	-1.9
Waist circumference	0.7	2.4	8.5	2.9	1.6	1.2	1.8	-1.4	-0.1	0.8	0.3	-1.1	-0.3	-2.1	-2.1	-1.7
Number of incorrect matches in round	0.4	0.6	2.0	-0.5	-0.8	-1.4	-0.4	-0.9	0.4	-1.4	-0.5	-0.7	0.1	-0.5	-0.9	-0.8
Past tobacco smoking	0.7	1.3	2.9	-1.6	-0.8	-1.3	0.1	1.1	0.1	-1.1	-0.2	1.2	0.9	1.7	1.6	1.5
Alcohol usually taken with meals	0.7	1.1	5.7	0.5	0.4	1.2	0.8	0.3	-1.3	2.4	1.5	0.3	-1.5	-0.1	-0.3	-0.2
Nervous feelings	0.3	0.6	2.9	-0.5	-0.7	-0.5	0.6	0.2	0.4	-1.7	-0.5	0.2	0.8	0.9	0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.1	0.0	-1.4	-1.2	0.7	0.3	-0.9	-0.8	0.6	0.2	-1.5	0.1	0.4	0.1
Hearing difficulty/problems with background noise	0.7	1.1	5.2	-0.7	-0.8	-1.4	-0.4	0.8	-0.1	-2.3	-0.2	0.5	0.4	1.3	1.4	1.1
Hair/balding pattern: Pattern 2	1.0	1.2	2.5	1.0	0.3	-0.8	1.5	-1.6	0.8	-0.0	-0.8	-1.4	0.3	-1.5	-1.3	-1.5
Had menopause	1.7	2.1	6.0	1.8	-0.6	1.8	2.4	-1.0	1.5	0.7	-1.4	-1.2	1.9	-1.1	-0.9	-1.0
Had other major operations	1.2	1.4	6.0	-0.8	0.2	-0.5	-1.2	1.0	-0.4	-2.4	0.1	1.0	-0.1	1.9	1.5	1.4
Forced vital capacity (FVC)	1.8	7.0	19.3	1.1	-0.6	0.8	-1.1	2.5	-4.2	2.4	4.3	2.9	-4.4	2.0	1.9	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	4.6	0.6	0.5	0.5	-2.1	1.2	-1.6	0.1	1.5	1.3	-1.8	0.7	0.8	1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	0.2	1.4	1.1	0.6	0.6	-1.0	-0.2	1.0	0.7	-1.4	0.5	0.7	0.7
Qualifications: None of the above	0.8	1.7	3.2	-0.1	-0.4	1.1	1.2	-1.5	1.7	-0.7	-1.7	-1.4	1.8	-1.3	-1.4	-1.3
Financial difficulties in last 2 years	2.3	3.1	6.0	2.0	-0.6	-1.8	0.2	-2.2	1.5	0.6	-1.5	-2.1	0.4	-2.4	-2.5	-2.4
Mouth/teeth dental problems	1.0	1.5	4.7	1.1	1.1	1.0	0.6	1.4	-1.2	2.2	1.3	1.3	-0.9	0.9	1.1	1.3
Heart attack	0.8	1.0	2.3	1.5	1.5	-0.0	0.8	-0.9	0.6	0.5	-0.6	-1.1	0.6	-1.2	-1.1	-1.2
Allergy	2.3	5.3	10.5	-0.0	-1.4	-0.7	-0.4	-3.2	2.7	-0.6	-2.7	-3.1	2.2	-2.6	-3.2	-3.0
Pain all over the body in last month	0.4	0.4	2.5	-1.1	-0.1	-1.6	0.4	0.5	-0.1	-1.0	-0.1	0.3	-0.2	0.3	0.3	0.6
Diabetes (self-reported)	1.1	1.7	4.6	-0.9	-0.4	0.1	2.1	-1.3	1.2	0.7	-1.1	-1.4	1.1	-1.9	-1.7	-1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.5	0.7	-0.1	1.2	0.1	1.5	-1.5	0.9	1.6	1.5	-1.4	1.1	1.1	1.3
Medication: Ramipril	0.7	0.9	1.8	-0.3	-0.7	0.5	0.9	-1.2	1.0	-0.6	-1.0	-1.3	0.7	-0.8	-1.2	-1.3
Medication: Simvastatin	1.2	1.8	4.0	2.0	1.5	0.9	1.6	-1.3	0.3	1.4	-0.0	-1.1	-0.1	-1.6	-1.8	-1.6
Fluid intelligence score	0.6	1.2	2.0	-1.4	-0.8	0.5	-0.4	1.2	-1.1	0.7	1.2	1.3	-1.0	1.3	1.4	1.2
Illnesses of siblings	3.3	4.7	9.3	-0.4	-1.8	-1.2	-3.0	2.4	-2.4	-1.2	2.0	2.3	-2.5	2.5	2.5	2.5
Neuroticism score	0.4	0.8	3.2	-0.8	-1.8	-1.5	0.5	0.2	0.3	-1.5	-0.6	-0.1	0.5	0.1	0.4	0.2
Weight	0.5	2.5	7.5	2.7	-0.2	1.6	0.1	-0.3	-2.1	1.1	2.2	0.2	-2.7	-1.5	-1.2	-0.8
Impedance of arm (right)	0.4	1.8	5.7	-0.0	0.5	0.3	1.9	-1.4	2.1	-0.0	-2.0	-1.3	2.4	-0.4	-0.8	-1.1
Arm fat percentage (right)	1.2	4.6	12.1	3.5	1.7	2.4	1.5	-2.3	0.6	1.4	-0.4	-2.0	0.2	-2.9	-3.0	-2.6
Trunk fat-free mass	0.8	4.7	18.0	0.5	-1.8	0.2	-1.2	1.7	-3.7	1.2	3.7	2.1	-4.2	0.4	0.9	1.2
Hip circumference	0.4	1.5	7.1	2.7	0.7	0.8	0.6	-0.6	-1.3	0.4	1.3	-0.2	-1.8	-1.4	-1.2	-0.9
Time employed in main current job	1.5	1.7	4.1	0.1	0.4	0.6	0.9	-1.9	1.2	-0.9	-1.3	-1.7	0.8	-1.6	-2.0	-1.7
Alcohol intake versus 10 years previously	0.8	1.2	2.7	-0.3	0.8	0.7	0.4	-1.6	1.0	-0.2	-0.8	-1.4	0.8	-1.4	-1.6	-1.6
Father’s age at death	0.3	0.4	1.7	-0.1	-0.4	-0.4	-0.3	0.5	0.7	-0.2	-0.9	0.2	1.3	0.7	0.8	0.7
Worrier / anxious feelings	1.4	2.6	11.6	-1.7	-2.8	-3.4	0.0	0.5	0.3	-2.7	-0.7	0.3	0.5	1.0	0.9	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	7.5	1.1	-0.3	0.2	2.7	-1.2	0.2	0.8	-0.1	-1.0	0.1	-1.0	-1.2	-1.3
Falls in the last year	0.3	0.4	1.3	-0.5	0.4	1.0	0.1	-0.6	0.4	0.0	-0.7	-0.8	0.2	-1.1	-0.7	-0.7
Hair/balding pattern: Pattern 3	1.2	1.7	7.4	2.3	1.4	2.5	-0.0	0.4	-0.6	2.7	0.8	0.2	-0.3	-0.6	-0.2	-0.1
Number of live births	0.4	0.5	1.4	-1.0	0.6	1.0	1.2	0.0	-0.4	0.1	0.4	-0.2	-1.0	-0.9	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	7.5	0.9	-0.4	0.7	-0.3	1.2	-2.4	1.7	2.4	1.4	-2.7	0.9	1.0	1.0
Pulse rate	0.2	0.4	0.8	0.8	0.9	0.9	0.6	-0.4	-0.1	0.2	-0.1	-0.5	-0.6	-0.5	-0.8	-0.5
Happiness	1.2	1.4	4.0	0.0	-1.0	-1.7	-0.2	-1.2	1.3	-2.0	-1.5	-1.4	0.6	-0.9	-1.0	-1.1
Noisy workplace	0.6	0.7	3.0	-0.2	1.7	0.8	-0.3	0.8	-1.0	-0.3	1.0	1.0	-0.9	0.8	0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.9	-1.2	-0.9	-1.2	-0.8	0.6	-0.3	-0.9	0.3	0.7	0.1	1.2	1.4	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.2	-0.8	-0.6	-0.9	-0.6	-1.2	1.6	-1.3	-1.4	-0.8	1.8	-0.1	-0.3	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	1.0	0.7	1.3	-0.3	-0.7	-0.0	0.3	0.2	-0.6	-0.1	-0.8	-1.1	-1.0
Asthma	1.0	2.0	3.9	-0.1	2.0	1.4	1.3	1.7	-1.1	0.3	1.2	1.7	-0.4	1.8	1.9	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.8	-0.3	0.4	-2.2	0.6	-1.8	1.2	-1.0	-1.3	-1.8	0.7	-1.7	-1.7	-1.7
Medication: Cholesterol lowering	0.4	0.5	1.4	0.8	0.7	-0.1	1.2	-0.5	0.5	1.1	-0.2	-0.5	0.8	-0.6	-0.9	-0.8
Depression (self-reported)	0.9	1.1	2.5	-0.4	-0.4	-0.4	-0.6	1.2	-1.1	0.7	1.4	1.4	-0.3	1.5	1.6	1.1
Medication: Lansoprazole	3.4	3.8	6.8	-0.5	0.3	-2.1	1.9	-2.3	2.3	-2.0	-2.6	-2.4	1.5	-2.1	-1.9	-2.1
Prospective memory result	0.2	0.2	0.6	0.1	-0.3	-0.4	-0.7	-0.5	0.1	-0.8	-0.2	-0.4	-0.1	-0.6	-0.5	-0.6
Lung cancer (father)	2.1	2.5	4.0	-2.0	-1.6	-1.0	-1.4	1.9	-1.4	-0.5	1.4	1.8	-0.9	1.8	1.9	2.0
Illnesses of mother	0.5	0.6	2.3	-1.5	0.2	-0.1	-1.0	0.3	0.6	-1.0	-0.6	0.3	1.1	0.8	0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	7.0	-0.4	-0.5	0.5	-0.6	1.8	-2.5	1.2	2.5	1.9	-2.6	1.8	1.7	1.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.2	0.4	-0.7	-0.7	-1.5	-0.8	0.2	-0.7	-0.2	-0.8	-0.3	-1.1	-1.1	-0.8
Impedance of arm (left)	0.1	0.5	2.6	-0.3	0.2	-0.0	1.1	-0.5	1.1	0.0	-1.0	-0.4	1.6	0.3	-0.1	-0.2
Arm fat mass (right)	0.6	2.5	9.3	3.1	0.8	2.0	0.5	-1.2	-0.9	1.0	1.0	-0.7	-1.4	-2.1	-2.0	-1.6
Trunk predicted mass	0.9	4.9	18.3	0.5	-1.8	0.2	-1.3	1.8	-3.7	1.2	3.8	2.1	-4.3	0.5	1.0	1.2
Standing height	0.7	6.8	22.7	0.1	-3.0	-0.2	-1.0	2.2	-4.3	1.3	4.3	2.6	-4.8	1.1	1.5	1.6
Length of working week for main job	0.4	0.5	2.1	-0.4	0.5	0.2	0.4	0.7	-0.4	0.2	0.6	0.9	-0.1	1.4	1.0	0.7
Exposure to tobacco smoke at home	1.4	1.6	3.3	-1.0	-0.9	-0.4	-0.6	1.8	-1.5	0.2	1.6	1.6	-0.9	1.1	1.5	1.7
Breastfed as a baby	2.2	2.7	7.2	1.0	1.5	2.7	-0.6	1.4	-2.1	1.5	2.2	1.3	-2.1	1.6	1.0	1.1
Tense / ‘highly strung’	0.3	0.4	1.8	-0.9	-1.0	-1.3	-0.6	0.3	0.3	-1.0	-0.4	0.1	0.4	-0.0	0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.3	-0.7	-0.4	-1.2	-0.4	0.4	-0.4	-0.2	0.2	0.2	-0.5	0.2	0.4	0.4
Hair/balding pattern: Pattern 4	1.4	3.3	14.2	-3.4	-2.6	-3.8	-0.9	0.9	-0.2	-2.4	-0.2	0.6	0.0	0.9	1.0	1.0
Birth weight of first child	0.1	0.1	0.4	0.6	0.1	0.6	-0.1	0.2	-0.1	-0.1	0.2	0.3	-0.5	-0.0	0.1	0.1
Peak expiratory flow (PEF)	0.1	0.2	1.3	0.7	-1.1	-0.2	-0.3	-0.1	-0.0	-0.5	-0.2	-0.2	-0.4	-0.4	0.1	0.0
Pulse wave reflection index	0.5	0.6	2.9	-0.6	-1.2	-0.1	-1.7	0.4	-0.9	0.8	1.0	0.3	-0.7	-0.0	0.1	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.4	1.0	0.5	1.0	1.5	-1.1	1.2	0.6	-1.0	-1.0	1.2	-0.9	-1.1	-1.2
Loud music exposure frequency	0.7	0.8	4.1	1.0	-2.0	0.3	-0.9	0.7	-0.9	-0.3	0.8	0.7	-1.1	0.5	0.5	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.5	-0.1	-0.4	-0.5	-1.0	-0.6	0.0	1.2	0.3	-0.4	-0.3	-0.3	-0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	9.4	-1.6	-2.6	-3.1	-1.2	-0.9	0.9	-2.2	-1.1	-0.8	0.7	-0.4	-0.2	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.7	0.8	0.4	-0.2	-0.4	0.5	-0.9	1.3	1.1	0.7	-0.6	-0.2	0.1	0.3
Medication: Paracetamol	0.6	1.0	2.6	-0.8	0.6	0.0	-0.3	-1.1	-0.3	-0.9	-0.2	-1.4	-0.9	-1.6	-1.6	-1.3
Headache pain in last month	0.5	0.8	2.1	-0.3	-1.5	-0.5	-1.3	0.5	-1.2	1.2	1.1	0.3	-1.4	-0.1	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	5.1	-0.3	-0.6	0.4	-2.3	1.9	-1.7	-1.2	1.2	1.7	-1.6	1.7	2.2	2.2
Glaucoma (self-reported)	0.4	0.5	2.0	0.1	-0.4	1.2	1.4	0.1	0.8	0.9	-0.6	-0.1	1.1	0.1	0.2	-0.0
Gout (self-reported)	0.4	0.5	2.6	1.6	0.4	0.8	-0.1	-0.5	-0.3	0.8	0.5	-0.1	-0.5	-0.6	-0.8	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	4.4	-1.2	-1.4	-0.7	-2.1	-0.2	-0.1	-0.8	-0.0	-0.1	-0.5	-0.2	-0.4	-0.1
Medication: Amlodipine	3.5	4.9	8.1	0.4	1.9	0.5	2.8	-2.7	2.8	-0.6	-2.8	-2.7	2.0	-2.3	-2.4	-2.6
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.9	0.3	0.4	0.8	0.1	2.0	-1.2	-0.4	1.3	2.0	-0.9	1.9	1.9	1.8
Birth weight	0.5	1.2	2.3	1.4	-0.8	1.4	-0.8	0.7	-1.5	1.0	1.5	0.8	-1.5	0.7	0.2	0.6
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.5	-0.6	-1.1	-2.0	-0.9	1.2	-1.7	-0.8	1.4	1.0	-2.4	0.6	1.1	1.0
High blood pressure (siblings)	1.6	2.3	5.4	1.2	2.1	2.1	2.0	-1.1	1.0	2.3	-0.6	-1.1	1.0	-1.2	-1.4	-1.4
Forced vital capacity (FVC), Best measure	1.9	6.8	16.3	-0.2	-0.7	0.8	-1.2	2.8	-3.9	1.8	4.0	3.0	-4.0	2.6	2.4	2.5
Body fat percentage	1.1	4.3	11.3	3.4	1.6	2.1	0.9	-2.4	0.7	0.6	-0.6	-2.0	0.3	-3.0	-3.0	-2.7
Leg fat percentage (right)	1.5	5.6	12.2	2.7	1.5	1.5	1.5	-3.1	1.9	0.1	-1.8	-2.8	1.3	-3.4	-3.5	-3.1
Arm fat-free mass (right)	0.8	4.1	17.4	1.0	-1.1	0.2	-1.8	1.3	-3.6	0.7	3.5	1.7	-4.2	-0.1	0.4	0.8
Exposure to tobacco smoke outside home	1.0	1.3	3.0	-0.4	-0.3	0.5	1.0	-1.5	1.0	1.0	-0.6	-1.2	1.1	-1.6	-1.7	-1.7
Comparative body size at age 10	1.7	4.8	10.7	-0.0	-1.5	0.8	-1.1	2.6	-3.1	0.6	3.3	3.0	-2.9	1.9	2.1	2.4
Number of full brothers	0.2	0.3	1.4	0.3	1.2	0.2	-1.2	0.1	0.2	-0.2	-0.1	0.1	0.3	0.4	0.1	0.1
Worry too long after embarrassment	0.5	0.8	3.6	0.1	-1.9	-0.9	-0.3	0.9	-0.9	-0.0	0.8	0.6	-1.0	0.8	1.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.6	6.0	11.9	0.1	0.3	0.5	-0.4	3.5	-3.1	1.6	3.1	3.3	-2.2	2.8	3.1	3.3
Wheeze or whistling in the chest in last year	0.4	0.7	5.5	0.4	0.2	1.6	2.4	-0.4	0.3	0.1	-0.0	-0.3	0.4	-0.4	-0.4	-0.6
Number of children fathered	0.3	0.3	1.1	-0.8	1.0	0.3	-0.1	0.4	0.5	-0.2	-0.3	0.4	0.8	0.6	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.4	-1.6	-0.8	-2.1	0.2	1.4	-0.7	-1.0	0.6	1.3	-0.7	1.1	1.4	1.3
Age at first live birth	1.4	2.4	5.5	0.5	-0.2	-1.1	-0.0	-1.9	2.3	-2.3	-2.4	-1.8	1.9	-0.8	-0.9	-1.3
Pulse wave peak to peak time	0.6	0.7	2.8	-0.4	0.5	0.7	1.7	0.8	-0.3	0.7	0.4	0.8	0.0	1.1	1.1	0.8
Health satisfaction	1.2	1.6	4.9	2.2	1.3	-0.3	1.5	-0.8	1.5	-1.4	-1.5	-0.9	1.7	-0.2	-0.5	-0.6
Shortness of breath walking on level ground	1.5	1.8	6.1	2.5	1.2	1.3	1.3	-1.5	1.2	-0.5	-1.1	-1.4	1.5	-0.8	-1.2	-1.3
Qualifications: College or University degree	0.6	1.9	7.5	-1.2	-0.6	-1.5	-2.7	1.1	-1.1	-0.6	1.1	1.2	-1.1	1.6	1.5	1.3
Eye problems/disorders: None of the above	0.3	0.3	1.8	-0.1	-0.6	-1.3	-1.1	-0.1	0.3	-0.5	-0.3	0.1	0.1	0.3	0.0	0.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.6	-1.4	-1.6	-0.6	0.2	-1.3	1.6	-0.6	-1.5	-1.2	1.4	-0.9	-1.0	-1.1
Emphysema/chronic bronchitis	0.3	0.3	1.5	-1.0	-1.2	0.2	-0.1	-0.3	-0.4	0.4	0.5	-0.2	-0.3	-0.6	-0.6	-0.5
Medication for pain relief, constipation, heartburn	2.6	4.4	11.6	0.5	-0.6	0.3	-1.9	2.9	-1.4	-0.1	1.5	3.0	-0.6	3.2	3.4	3.1
Neck or shoulder pain in last month	0.3	0.4	2.1	0.0	1.1	0.2	1.5	0.4	-0.4	-0.4	-0.1	-0.2	-0.7	0.0	0.4	0.2
Medication: Blood pressure	3.4	6.0	12.9	0.2	0.3	0.1	2.5	-3.2	2.6	1.7	-2.1	-3.0	1.9	-3.0	-3.6	-3.6
Angina (self-reported)	0.1	0.2	0.9	0.4	-0.3	-1.0	-0.8	0.1	-0.3	-0.1	0.5	0.5	-0.1	0.0	0.0	0.1
Migraine (self-reported)	2.3	2.9	4.9	-0.1	-1.1	0.2	-1.8	2.2	-2.2	0.1	2.1	2.1	-1.9	1.9	1.7	2.1
Medication: Ibuprofen	1.1	1.3	6.5	-0.6	0.1	-2.5	-0.0	-1.3	1.0	-1.3	-1.1	-1.2	0.4	-1.0	-1.1	-1.1
Medication: Allopurinol	0.5	0.7	1.9	1.0	0.1	1.2	-0.1	-0.3	-0.8	1.4	1.1	0.2	-1.0	-0.6	-0.8	-0.4
Medication: Omeprazole	0.8	0.9	1.6	-1.3	-0.8	-0.9	0.4	0.9	-1.1	-1.0	0.9	0.8	-0.7	1.1	1.2	1.1
Medication: Seretide 50 evohaler	0.6	0.7	2.3	0.3	1.0	0.8	1.4	0.1	1.0	-0.6	-0.9	-0.0	1.5	0.4	0.4	0.2
Mean time to correctly identify matches	1.5	2.8	5.4	-0.7	-1.5	-0.0	0.9	2.3	-2.2	0.1	2.1	2.2	-1.2	1.7	2.0	2.3
Heart disease (mother)	2.5	3.0	4.8	0.9	0.6	-0.5	1.8	-2.2	2.0	-0.4	-1.9	-2.1	2.0	-2.2	-2.1	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	-0.1	-0.7	0.2	-1.3	1.3	-1.0	-0.3	0.6	1.0	-1.3	1.5	1.5	1.3
Whole body fat mass	0.7	2.8	10.5	3.2	0.6	2.1	0.6	-1.5	-0.5	0.9	0.6	-1.1	-0.9	-2.5	-2.4	-1.9
Leg fat mass (right)	0.6	2.5	7.1	2.7	0.2	1.3	0.6	-1.8	0.0	0.5	0.0	-1.4	-0.6	-2.6	-2.5	-2.0
Arm predicted mass (right)	0.7	3.4	15.0	0.9	-1.4	-0.1	-1.5	1.0	-3.2	0.7	3.2	1.4	-3.9	-0.4	0.2	0.5
Pulse rate, automated reading	0.3	0.8	2.4	1.5	1.1	1.1	-0.5	0.5	-1.1	0.9	1.1	0.5	-1.3	0.3	-0.1	0.3
Alcohol intake frequency.	0.4	0.9	1.5	-0.3	-0.1	-0.1	1.2	-1.2	1.1	-1.1	-1.2	-1.1	0.9	-0.8	-1.0	-1.1
Comparative height size at age 10	1.3	7.3	21.1	0.5	-1.2	1.6	-1.9	2.7	-4.4	1.1	4.4	3.2	-4.6	1.3	1.7	2.1
Number of full sisters	0.2	0.3	0.7	-0.7	0.8	0.2	-0.8	-0.2	0.3	-0.6	-0.5	-0.4	0.8	-0.4	-0.4	-0.3
Suffer from ‘nerves’	0.4	0.6	1.4	-0.4	-0.9	-0.7	-0.1	0.8	-0.5	-1.2	0.4	0.7	-0.3	1.0	1.1	0.8
Overall health rating	1.2	2.5	4.2	1.2	0.8	0.1	2.0	-1.8	1.8	-0.7	-1.8	-1.7	2.0	-1.6	-1.9	-1.8
Chest pain or discomfort	0.5	0.8	2.5	-1.0	-0.4	-0.5	-0.1	1.0	-0.4	-0.9	0.5	1.1	-0.0	1.6	1.3	1.0
Had major operations	1.4	1.6	7.4	2.7	1.0	0.6	-0.3	0.7	-1.4	2.3	1.6	0.7	-1.2	-0.2	-0.1	0.3
Age at last live birth	0.9	1.3	2.8	0.2	-0.1	-0.0	0.9	-1.7	1.4	-0.5	-1.4	-1.6	1.0	-1.3	-1.4	-1.4
Family relationship satisfaction	0.1	0.1	0.9	-0.2	0.1	0.3	-0.2	-0.2	-0.2	0.9	0.2	-0.3	-0.7	-0.1	-0.4	-0.2
Leg pain on walking	0.7	0.9	6.8	0.6	1.3	-1.3	-0.4	-0.1	0.6	-2.6	-0.7	-0.0	0.6	0.3	0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	9.5	-3.1	-0.6	-0.7	-0.7	1.6	-1.0	-2.0	0.6	1.3	-1.0	1.4	1.8	1.7
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.3	-0.8	-0.6	-1.7	1.0	-2.1	1.8	-0.8	-1.6	-1.6	1.5	-1.4	-1.9	-1.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.1	-1.2	0.0	0.1	0.1	1.3	-0.3	-1.5	0.1	1.0	0.3	0.8	1.4	1.4
Medication: Aspirin	6.5	8.6	15.4	0.8	0.9	0.7	3.3	-3.7	3.2	0.7	-2.9	-3.6	3.0	-3.5	-3.9	-3.8
Supplements: Vitamin C	0.2	0.3	1.1	-0.9	0.4	-0.3	1.0	-0.2	-0.3	-0.8	-0.1	-0.4	-0.6	-0.3	-0.1	-0.1
Knee pain experienced in last month	0.7	1.0	3.1	1.7	0.7	0.7	0.9	-1.0	1.2	-0.8	-1.2	-0.9	1.2	-0.6	-0.6	-0.8
Hypertension (Self-reported)	1.6	4.4	10.9	0.1	1.1	0.1	3.3	-2.9	2.0	0.1	-1.6	-2.5	1.4	-2.4	-2.8	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.3	-0.8	-1.2	-1.8	0.6	0.0	0.1	-1.5	-0.4	-0.2	-0.3	-0.1	0.1	-0.0
Illnesses of father: Heart disease	1.3	1.8	7.8	-1.3	-0.9	-2.8	0.7	-1.5	1.3	-0.9	-1.3	-1.3	0.8	-0.9	-1.0	-1.4
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-0.0	0.6	0.3	0.1	-0.9	1.1	0.2	-1.0	-1.0	1.1	-1.0	-0.8	-1.0
Smoking status: Previous	0.5	0.7	3.0	1.1	0.7	1.7	-0.3	-0.2	-0.8	1.1	0.9	-0.2	-1.2	-0.5	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	12.4	0.6	-0.8	-0.8	-1.8	1.7	-3.2	0.2	3.2	2.2	-3.5	1.7	1.6	1.5
Whole body fat-free mass	0.8	4.5	17.8	0.9	-1.6	0.3	-1.4	1.5	-3.7	1.2	3.7	1.9	-4.2	0.1	0.6	0.9
Leg fat-free mass (right)	0.7	4.0	16.0	1.3	-1.5	0.5	-1.5	1.1	-3.4	1.2	3.4	1.6	-4.0	-0.3	0.1	0.5
Arm fat percentage (left)	0.9	3.7	10.5	3.2	1.6	2.2	1.0	-2.0	0.3	1.4	-0.0	-1.7	-0.1	-2.7	-2.8	-2.4
Average weekly red wine intake	0.5	0.7	1.5	-1.2	0.8	0.5	0.4	1.1	-0.3	0.1	0.3	1.0	0.1	1.1	1.2	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.8	-0.7	-1.1	0.1	0.5	-0.9	-1.0	0.7	0.5	-0.8	0.1	0.5	0.6
Mood swings	0.3	0.5	2.1	0.0	-1.0	0.1	1.5	-0.4	0.4	-1.1	-0.8	-0.7	0.5	-0.7	-0.1	-0.3
Loneliness, isolation	1.8	2.5	4.5	0.3	-1.3	-1.1	0.7	-2.0	2.0	0.3	-1.9	-2.1	1.6	-1.7	-1.8	-2.1
Long-standing illness, disability or infirmity	1.3	2.0	3.7	0.5	0.6	-1.2	1.9	-1.3	1.8	-1.8	-1.9	-1.4	1.9	-1.1	-0.8	-1.1
Ever had bowel cancer screening	0.8	1.0	3.4	1.1	1.8	1.5	0.4	-0.5	0.1	1.7	0.2	-0.3	0.3	-0.8	-1.0	-0.8
Diabetes diagnosed by doctor	0.7	1.2	3.7	-1.1	-0.2	0.2	1.9	-0.9	0.8	0.9	-0.7	-1.0	0.9	-1.7	-1.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	0.2	0.8	1.1	0.4	-0.9	0.5	1.0	-0.3	-0.7	-0.0	-0.8	-1.1	-1.1
Friendships satisfaction	0.3	0.3	0.7	-0.8	-0.3	-0.4	-0.5	0.6	-0.5	-0.5	0.2	0.5	-0.8	0.7	0.5	0.6
Qualifications: nursing, teaching	1.3	2.0	4.9	-1.1	-2.2	-2.2	-2.2	0.6	-0.8	-1.9	0.5	0.6	-1.4	1.2	1.1	0.8
Commuting to job workplace: Walk	0.9	0.9	2.8	0.8	-0.8	-0.3	-1.7	1.1	-0.6	-0.9	0.4	0.9	-0.5	1.3	1.2	1.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.7	-0.1	0.6	0.4	-0.4	-0.2	0.3	0.2	-0.4	-0.4	-0.7	-0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	-0.6	-0.1	0.3	-0.2	0.5	-0.6	-0.7	0.6	0.8	-0.4	1.0	0.7	0.6
Medication for cholesterol	2.3	3.5	6.9	-0.6	-1.5	-0.9	-1.8	2.6	-1.9	0.2	1.8	2.5	-1.5	2.1	2.4	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	6.2	1.3	0.8	2.5	0.0	-0.7	1.0	0.2	-1.0	-0.8	1.1	-0.8	-0.8	-0.6
Back pain experienced in last month	0.8	1.2	2.8	0.5	1.7	1.5	1.7	-0.9	0.8	0.5	-0.8	-0.9	0.9	-1.1	-0.9	-1.0
Mineral and other dietary supplements	0.5	0.7	2.2	1.5	0.4	0.6	-0.7	-0.9	0.9	-0.1	-0.7	-0.7	1.0	-0.6	-0.7	-0.9
Breast cancer (self-reported)	0.8	0.9	4.3	-1.1	-1.0	-2.1	-0.6	-0.8	0.6	-1.6	-0.7	-0.8	0.1	-0.3	-0.5	-0.6
Asthma (self-reported)	1.1	2.2	4.7	-0.1	1.9	1.4	1.3	1.9	-1.0	0.3	1.2	1.8	-0.2	2.1	2.2	1.7
Osteoporosis (self-reported)	1.8	2.2	4.8	-1.6	-1.1	-1.8	-1.8	1.5	-0.9	-1.0	0.8	1.5	-0.4	2.2	1.8	1.8
Osteoarthritis (self-reported)	5.0	6.5	13.2	2.0	1.1	0.0	1.6	-3.6	2.6	0.8	-2.2	-3.1	2.0	-3.4	-3.6	-3.6
Medication: Aspirin	5.4	7.1	14.4	0.6	0.7	0.8	2.8	-3.5	2.7	0.8	-2.5	-3.4	2.1	-3.5	-3.8	-3.7
Medication: Gliclazide	1.5	1.7	4.1	-0.1	-0.8	-0.7	1.3	-1.8	0.9	0.7	-0.8	-1.6	0.6	-2.0	-1.8	-1.9
Illnesses of father: None of the above (group 1)	1.8	2.2	4.1	0.9	0.7	1.8	-1.2	1.6	-2.0	1.2	2.0	1.6	-1.9	1.1	1.3	1.4
Smoking status: Current	3.6	5.7	10.9	0.5	1.6	0.1	1.5	-3.1	2.5	0.4	-2.5	-3.3	2.1	-3.1	-3.3	-3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.8	-0.6	-1.3	0.4	0.3	0.7	-0.5	0.4	0.4	0.5	-0.2	0.7	0.8	0.8
Whole body water mass	0.8	4.5	18.2	1.0	-1.5	0.3	-1.4	1.3	-3.7	1.3	3.7	1.8	-4.3	-0.1	0.4	0.8
Leg predicted mass (right)	0.8	4.0	16.0	1.4	-1.5	0.6	-1.5	1.0	-3.4	1.3	3.5	1.5	-4.0	-0.4	0.1	0.5
Arm fat mass (left)	0.6	2.3	8.7	3.0	0.8	1.8	0.3	-1.0	-1.0	1.1	1.2	-0.6	-1.5	-2.0	-1.9	-1.4
Number of self-reported non-cancer illnesses	1.0	1.7	11.3	0.7	0.6	0.5	3.4	-0.9	0.7	0.9	-0.4	-0.8	0.8	-1.5	-1.5	-1.3
Average weekly champagne plus white wine intake	0.5	0.7	2.4	0.0	-1.6	-1.2	-1.2	0.7	-0.4	-0.8	0.3	0.5	-0.2	0.9	0.8	0.7
Miserableness	0.4	0.7	3.0	0.2	-1.7	0.6	1.0	-0.8	0.7	-0.2	-0.8	-0.9	0.8	-0.9	-0.7	-0.8
Guilty feelings	1.9	2.8	13.5	-2.3	-3.7	-3.3	-1.2	0.3	-0.2	-2.1	-0.2	0.0	-0.5	0.4	0.3	0.3
Wears glasses or contact lenses	0.3	0.3	1.6	0.5	0.8	1.3	-0.5	0.4	-0.1	0.1	0.3	0.3	0.4	0.7	0.5	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.1	-0.5	0.2	-0.2	-0.3	0.1	0.7	0.1	0.1	0.1	0.3	0.0	-0.1
Hearing aid user	0.7	0.8	2.1	0.3	0.6	0.6	0.4	-1.3	0.5	0.2	-0.4	-1.3	0.6	-1.2	-1.3	-1.4
Mother’s age at death	0.2	0.2	1.2	1.1	0.2	0.8	0.6	0.2	-0.2	0.7	0.2	0.0	-0.5	-0.1	-0.0	-0.0
Financial situation satisfaction	0.7	0.9	5.3	2.3	1.4	0.2	0.6	-0.7	-0.3	0.0	0.1	-0.7	-0.8	-0.8	-0.8	-0.9
Tinnitus: Yes, now most or all of the time	1.3	1.6	5.4	-0.1	0.0	-1.9	-2.3	1.3	-1.0	0.1	1.1	1.4	-0.5	1.2	1.3	1.4
Commuting to job workplace: Public transport	1.4	1.7	7.0	1.5	1.9	2.7	0.4	1.0	-0.7	1.9	0.9	0.8	-0.1	0.9	1.0	0.6
Eye problems/disorders: Glaucoma	1.2	1.4	6.8	-0.6	0.4	1.3	1.9	-0.5	1.8	0.4	-1.5	-0.6	2.6	-0.0	0.0	-0.4
Medication: Blood pressure	2.1	4.0	7.5	0.6	1.2	0.3	2.0	-2.7	2.1	-1.3	-2.2	-2.6	1.5	-2.3	-2.5	-2.6
Pain type(s) experienced in last month: Hip pain	1.4	1.7	5.6	1.3	1.9	1.2	2.4	-1.0	1.4	-0.6	-1.3	-1.0	1.5	-0.8	-0.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.9	-1.0	0.1	-0.0	0.4	1.3	-1.4	0.5	1.2	1.1	-1.3	1.1	1.2	1.2
High cholesterol (Self-reported)	1.1	1.9	4.2	1.3	0.9	1.0	1.7	-1.9	0.6	1.2	-0.3	-1.6	0.4	-1.5	-2.1	-2.0
Medication: Bendroflumethiazide	4.2	6.3	13.2	0.9	2.6	1.4	3.6	-3.0	2.2	1.5	-2.0	-2.9	2.1	-2.9	-3.0	-3.0
Medication: Paracetamol	0.9	1.3	3.2	-0.8	0.2	-0.6	-0.4	-1.4	0.1	-1.6	-0.6	-1.6	-0.5	-1.7	-1.8	-1.5
Medication: Lisinopril	0.8	1.1	2.3	0.7	1.4	0.4	1.2	-1.2	1.2	-0.6	-1.2	-1.2	1.5	-0.7	-0.7	-0.9
Medication: Atorvastatin	0.7	0.8	7.5	-2.7	-0.9	-0.2	-1.1	-0.2	-0.2	-0.4	-0.1	-0.4	-0.4	-0.2	-0.5	-0.4
Illnesses of father: High blood pressure	0.3	0.3	2.4	0.2	-0.1	-1.6	0.2	-0.0	-0.2	-1.0	0.2	0.2	-0.7	-0.2	-0.1	0.1
Alcohol drinker status: Never	0.9	1.0	3.4	-1.8	-0.1	-1.2	1.0	0.4	0.5	-1.6	-0.5	0.7	1.0	1.1	1.1	0.8
Ever smoked	0.8	1.4	3.5	1.9	0.2	1.4	-0.8	-0.8	-0.7	1.3	0.7	-0.9	-1.3	-1.6	-1.4	-1.3
Basal metabolic rate	0.7	3.9	15.9	1.4	-1.2	0.6	-1.2	1.1	-3.4	1.2	3.5	1.6	-4.0	-0.3	0.2	0.5
Leg fat percentage (left)	1.6	5.9	12.9	2.8	1.5	1.5	1.2	-3.1	1.8	0.1	-1.8	-2.9	1.1	-3.5	-3.6	-3.2
Arm fat-free mass (left)	0.6	3.0	13.5	1.3	-0.9	0.6	-1.2	0.8	-3.0	0.8	3.0	1.2	-3.7	-0.5	0.1	0.3
Number of operations (self-reported)	0.3	0.4	1.2	-0.2	0.6	0.5	0.2	0.6	-1.0	-0.5	1.1	0.9	-0.7	0.6	0.4	0.6
Average weekly beer plus cider intake	0.2	0.3	1.1	-0.3	-1.0	-1.1	1.0	0.3	0.2	-0.6	-0.4	0.2	-0.1	0.0	0.4	0.3
Irritability	0.3	0.4	3.0	-0.1	-0.6	-0.8	0.5	0.1	0.5	-1.7	-0.8	-0.2	0.3	-0.1	0.4	0.2
Risk taking	0.7	1.0	2.6	0.2	1.6	1.1	0.5	0.7	-1.2	1.4	1.3	0.7	-1.6	-0.4	-0.0	0.2
Ever had prostate specific antigen (PSA) test	2.3	2.6	9.8	-1.8	-3.1	-1.7	-2.4	0.9	0.1	-2.4	-0.3	0.8	0.9	1.3	1.1	1.3
Fractured/broken bones in last 5 years	0.7	0.9	2.1	0.5	-1.5	-0.7	-0.7	0.6	-1.4	0.5	1.4	0.8	-1.3	0.6	0.5	0.5
Age started oral contraceptive pill	0.8	1.0	4.3	2.1	0.5	0.8	1.0	-1.2	0.8	-0.2	-0.7	-1.0	1.0	-0.3	-0.8	-1.0
Diastolic blood pressure, automated reading	0.2	0.8	2.0	0.9	0.3	1.2	0.6	0.4	-1.3	1.1	1.3	0.5	-1.4	-0.3	-0.2	0.2
Ever depressed for a whole week	0.5	0.6	3.1	0.0	1.8	0.5	0.3	0.5	-0.9	-0.3	0.9	0.7	-1.0	0.5	0.7	0.6
Unable to work because of sickness or disability	0.2	0.3	0.9	-1.0	0.7	0.7	-0.3	-0.3	0.5	-0.7	-0.5	-0.5	0.3	-0.2	-0.4	-0.5
Commuting to job workplace: Cycle	2.5	3.0	6.2	-0.8	-0.4	-0.3	-1.2	2.1	-1.8	-1.4	1.7	2.2	-1.6	2.4	2.5	2.2
Myopia	0.7	1.0	3.1	0.5	0.5	0.6	0.0	1.2	-0.5	0.0	0.6	1.3	-0.2	1.8	1.6	1.4
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.9	0.3	-1.1	0.3	-2.8	2.5	-1.8	0.4	1.6	2.1	-1.3	2.2	2.6	2.5
Cholesterol lowering medication	2.2	3.3	8.1	0.9	0.9	1.7	1.6	-2.4	1.2	0.7	-1.1	-2.3	0.6	-2.4	-2.8	-2.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.9	-1.0	-0.8	-0.6	0.6	1.0	-1.4	-0.7	1.1	1.0	-1.1	1.2	1.3	1.2
Pain experienced in last month	0.2	0.3	1.3	0.0	-0.3	0.4	-1.1	-0.5	0.7	0.8	-0.4	-0.3	0.9	0.0	-0.2	-0.4
Supplements: Calcium	0.6	0.6	2.0	-0.9	-1.0	-1.4	-1.3	0.2	-0.4	-0.9	0.2	0.3	-1.1	0.3	-0.1	0.3
Basal cell carcinoma (self-reported)	0.4	0.5	3.1	-1.8	0.8	-0.1	0.2	-0.6	0.4	0.9	-0.1	-0.4	0.9	-0.4	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.6	1.3	1.6	-0.1	0.8	-0.8	0.6	0.6	-0.6	-1.0	0.6	-1.0	-1.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	0.6	0.6	-0.4	-0.5	0.4	-0.9	1.1	1.1	0.7	-0.5	-0.1	0.1	0.2
Heart disease (siblings)	0.2	0.2	0.5	0.4	-0.1	-0.3	0.7	-0.7	0.2	-0.1	0.0	-0.3	0.5	-0.3	-0.6	-0.7
Alcohol drinker status: Previous	0.7	0.7	3.0	1.3	-0.1	0.7	-0.0	-0.1	-0.8	1.0	0.6	-0.2	-1.7	-1.2	-0.8	-0.6
Pack years of smoking	1.4	2.0	3.2	0.7	-1.4	-0.0	1.6	-1.6	1.7	-0.9	-1.7	-1.6	1.8	-1.5	-1.4	-1.4
Impedance of whole body	0.2	1.0	3.8	-0.9	0.2	-0.8	0.7	-0.6	1.6	-1.1	-1.7	-0.7	1.9	0.3	-0.0	-0.2
Leg fat mass (left)	0.7	2.7	7.9	2.8	0.5	1.5	0.5	-1.8	-0.0	0.5	0.1	-1.5	-0.7	-2.7	-2.6	-2.1
Arm predicted mass (left)	0.7	3.4	15.1	1.0	-1.2	0.3	-1.4	1.0	-3.2	0.7	3.2	1.4	-3.9	-0.3	0.2	0.5