Hub : Genes

CBR3-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.172 0.0520 1.0e-04 -0.001 NA -0.003 NA -0.003 4.4e-01 NA 8.3e-01 NA 8.8e-01
2 GTEx Adipose Visceral Omentum 0.238 0.0820 1.0e-03 -0.004 NA -0.005 NA -0.005 6.3e-01 NA 8.8e-01 NA 7.0e-01
3 GTEx Artery Aorta 0.116 0.0510 9.9e-03 -0.002 NA 0.030 NA 0.025 4.5e-01 NA 8.9e-03 NA 1.4e-02
4 GTEx Artery Tibial 0.120 0.0408 5.4e-04 0.014 NA 0.013 NA 0.010 2.7e-02 NA 3.0e-02 NA 5.1e-02
5 GTEx Colon Transverse 0.259 0.0750 1.0e-04 0.071 NA 0.098 NA 0.103 2.8e-04 NA 2.0e-05 NA 1.4e-05
6 GTEx Esophagus Mucosa 0.305 0.0610 1.8e-09 0.279 NA 0.216 NA 0.276 7.1e-19 NA 1.7e-14 NA 1.3e-18
7 GTEx Nerve Tibial 0.129 0.0455 1.4e-03 0.097 NA 0.063 NA 0.088 2.2e-07 NA 2.8e-05 NA 8.5e-07
8 GTEx Pancreas 0.268 0.0860 6.5e-04 0.162 NA 0.100 NA 0.148 2.3e-07 NA 5.3e-05 NA 8.5e-07
9 GTEx Prostate 0.422 0.0960 1.3e-04 0.132 NA 0.201 NA 0.226 3.4e-04 NA 9.0e-06 NA 2.2e-06
10 GTEx Skin Sun Exposed Lower leg 0.212 0.0510 1.1e-06 0.118 NA 0.114 NA 0.124 5.2e-10 NA 1.1e-09 NA 2.0e-10
11 GTEx Stomach 0.274 0.0740 1.5e-04 0.112 NA 0.070 NA 0.129 5.0e-06 NA 3.1e-04 NA 1.0e-06
12 GTEx Testis 0.489 0.0800 2.7e-07 0.247 NA 0.255 NA 0.250 2.4e-11 NA 1.1e-11 NA 1.8e-11
13 GTEx Thyroid 0.307 0.0530 1.4e-13 0.274 NA 0.248 NA 0.261 3.9e-21 NA 5.4e-19 NA 4.6e-20

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.9 1.5 3.3 0.5 0.9 1.1 -0.1 1.5 -1.2 1.8 1.4 1.4 -0.8 1.3 1.4 1.3
Bipolar Disorder or Schizophrenia 3.9 9.6 16.0 -0.5 -0.8 0.6 -3.0 3.9 -4.0 1.2 4.0 3.9 -3.7 3.3 3.6 3.6
Depressed Affect (Nagel 2018) 0.6 1.3 2.4 0.3 -1.6 0.2 1.2 -1.2 1.2 -0.6 -1.5 -1.4 1.2 -1.2 -1.0 -1.2
Depression (Nagel 2018) 1.4 2.1 4.2 2.0 -0.5 0.5 1.8 -1.7 1.1 0.5 -1.1 -1.8 0.6 -2.1 -1.7 -2.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.4 -0.4 -0.1 1.5 0.8 0.5 -0.7 1.5 0.9 0.7 -0.6 0.5 0.6 0.4
Neuroticism (Nagel 2018) 0.4 0.9 5.5 -0.6 -2.4 -1.1 0.2 0.1 0.5 -1.5 -0.8 -0.2 0.6 0.3 0.5 0.3
Schizophrenia (2018) 4.9 10.2 17.3 -1.0 -1.7 -0.1 -3.8 3.8 -4.2 0.1 4.0 3.9 -4.2 3.2 3.5 3.6
Schizophrenia vs Biploar Disorder 0.8 1.1 5.7 -0.7 -1.8 -0.8 -2.4 0.3 -0.5 -1.4 0.3 0.4 -0.4 0.5 0.5 0.5
Worry (Nagel 2018) 0.5 1.0 2.9 -1.3 -1.7 -1.2 -0.7 0.5 0.3 -1.7 -0.4 0.4 0.5 1.1 1.0 0.8
Alzheimer’s Disease (in mother) 0.7 0.8 5.5 2.3 -0.1 1.1 -0.4 0.4 -0.6 0.9 0.7 0.6 -1.1 -0.0 0.3 0.4
Alzheimer’s Disease (in father) 0.8 0.8 2.6 -0.7 0.7 0.2 0.8 1.4 0.0 0.2 -0.1 1.1 0.4 1.1 1.6 1.4
Alzheimer’s Disease (including proxy) 0.7 0.9 2.5 1.6 -0.7 0.7 -0.5 1.3 -0.5 0.8 0.5 1.4 -0.4 0.6 1.3 1.3
Crohns Disease (2017) 0.2 0.5 2.3 -0.1 1.1 1.5 -0.1 0.6 0.2 -0.6 -0.2 0.5 0.5 0.7 0.7 0.7
Irritable Bowel Disease (IBD) 0.2 0.6 2.2 1.5 1.1 1.5 -0.0 0.6 -0.1 0.3 0.1 0.5 -0.2 0.6 0.4 0.5
Ulcerative Colitis (UC) 0.6 1.0 5.3 2.3 1.1 1.2 0.2 0.5 -0.7 1.4 0.8 0.5 -1.2 0.5 0.1 0.2
Major Depression (MDD) 0.3 0.4 0.7 -0.6 -0.4 -0.4 -0.8 0.9 -0.0 -0.5 0.0 0.8 0.4 0.6 0.7 0.9
Reaction Time 0.9 1.8 3.4 -1.1 -1.0 -0.1 0.3 1.8 -1.8 -0.3 1.5 1.7 -0.9 1.4 1.6 1.9
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.6 -0.8 -1.1 0.2 0.1 0.8 -1.0 0.9 1.3 1.0 -1.0 0.5 0.9 0.7
Breast Cancer 0.5 1.3 2.1 -0.1 -0.5 -1.1 1.0 -1.4 1.4 -0.8 -1.3 -1.4 0.6 -1.3 -1.4 -1.4
Ovarian Cancer 0.6 0.8 3.3 1.8 0.4 -0.0 0.4 -0.9 0.6 -0.9 -0.9 -1.1 0.2 -0.9 -0.8 -1.0
Prostate Cancer 3.1 4.3 9.7 -1.9 -1.2 -1.7 -1.2 2.6 -1.6 -1.7 1.3 2.4 -1.0 2.9 3.1 2.9
Age at First Birth 0.8 1.1 2.7 0.8 0.4 -1.1 0.0 -1.7 1.1 -0.3 -0.9 -1.3 0.5 -1.2 -1.3 -1.6
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.5 -0.2 -0.5 -0.5 0.6 -0.4 -0.6 0.2 0.4 -0.0 0.3 0.8 0.8
Body Mass Index (BMI) (2010) 0.6 0.8 2.8 1.0 0.5 0.9 0.4 -0.5 0.9 1.7 -0.6 -0.4 1.2 -0.8 -0.8 -0.7
Coronary Artery Disease (CAD) 0.7 0.9 1.8 -1.1 -0.5 -0.8 0.8 -0.8 1.3 -1.4 -1.4 -1.1 0.9 -0.4 -0.0 -0.7
Crohns Disease (2012) 0.6 0.9 5.1 0.5 2.3 1.1 1.0 0.9 -0.4 0.5 0.5 0.8 0.3 0.8 0.8 0.8
Mean Putamen Volume 0.4 0.5 2.6 0.7 0.3 -0.2 1.6 -0.2 0.9 -0.0 -0.9 -0.2 1.0 -0.4 -0.1 -0.1
Fasting Glucose 1.3 1.6 5.1 -0.5 1.0 0.1 2.0 -1.7 0.7 -0.4 -0.6 -1.8 2.2 -1.0 -1.1 -1.1
HbA1C 0.8 0.9 3.3 0.8 1.8 1.5 0.5 -1.1 0.7 0.3 -0.7 -1.1 0.1 -0.7 -0.7 -1.0
HDL Cholesterol 1.0 1.7 4.7 -2.2 -1.8 -0.4 0.3 1.2 -1.1 -1.6 0.8 0.7 -1.0 1.2 1.5 1.3
LDL Cholesterol 0.6 0.9 2.1 -0.1 0.9 -1.1 0.9 1.0 -0.3 -1.2 0.3 1.0 -0.4 1.4 1.5 1.1
Lupus 0.6 0.9 1.5 0.8 0.7 1.2 1.2 -0.6 -0.8 1.2 0.9 -0.2 -1.2 -1.2 -1.1 -0.7
Neuroticism (2016) 0.9 1.3 7.0 -1.1 -2.6 -1.5 -0.2 0.5 0.5 -1.8 -0.7 0.2 0.8 0.4 0.9 0.8
Primary Biliary Cirrhosis 1.0 1.4 3.7 0.3 -0.8 -0.2 -1.5 1.1 -1.9 1.2 1.9 1.2 -1.5 0.5 0.8 0.9
Rheumatoid Arthritis 0.2 0.3 0.8 0.5 -0.3 -0.7 0.7 0.7 -0.2 -0.1 0.1 0.7 0.3 0.5 0.9 0.9
Schizophrenia (2014) 6.6 14.5 24.9 -0.4 -1.9 0.1 -4.3 4.6 -5.0 0.4 4.9 4.8 -4.3 4.1 4.3 4.4
Triglycerides 0.5 0.8 3.9 -0.6 2.0 0.8 0.6 -0.5 1.1 0.6 -1.1 -0.6 1.2 -0.4 -0.6 -0.5
Type 2 Diabetes (T2D) (2012) 1.7 1.9 4.4 1.1 0.5 0.4 -0.3 -1.3 1.4 1.5 -1.2 -1.5 1.5 -2.0 -2.1 -1.7
Ulcerative Colitis 0.2 0.3 1.8 1.3 0.5 0.8 0.6 0.2 -0.3 0.8 0.2 0.1 -0.6 -0.1 -0.1 0.0
Blood Eosinophil Count 0.1 1.0 5.1 -0.0 1.3 1.0 0.5 0.7 -0.9 -2.3 0.6 0.6 -0.2 0.8 0.9 1.0
Blood Platelet Count 0.6 7.4 15.0 0.5 3.8 1.2 3.9 -2.8 3.3 -1.6 -3.5 -3.1 3.1 -1.7 -1.7 -2.5
Blood Red Count 0.2 1.6 8.9 -0.4 0.1 0.4 -0.7 -1.1 0.1 3.0 0.4 -0.9 0.6 -1.6 -2.0 -1.2
Blood White Count 1.1 7.9 13.9 -0.1 2.4 -0.2 2.5 -3.4 3.7 -0.5 -3.5 -3.3 3.6 -2.9 -3.2 -3.1
Heel T-Score 0.5 4.3 14.4 2.6 2.0 3.8 -2.0 -0.1 -1.6 3.8 1.6 -0.2 -1.5 -1.7 -1.1 -0.7
BMI 0.1 0.8 5.6 2.4 0.7 0.9 0.4 -0.5 -0.2 0.0 0.2 -0.4 -0.3 -1.3 -1.1 -0.7
Height 0.8 14.5 39.9 0.5 -3.3 0.8 -0.3 3.7 -6.1 3.0 6.3 4.2 -6.3 2.2 2.6 2.9
Waist Hip Ratio (WHR) 0.3 1.5 3.4 1.4 0.8 -0.0 0.8 -1.4 1.1 0.9 -0.7 -1.4 1.1 -1.7 -1.8 -1.7
Systolic Blood Pressure 0.3 1.6 6.8 -1.7 1.4 -1.2 2.6 -1.1 0.7 -0.8 -0.8 -1.0 0.2 -1.1 -1.0 -1.2
Smoking Status 1.5 3.7 8.2 1.7 1.5 1.0 0.7 -2.5 1.1 1.1 -1.1 -2.6 0.3 -2.8 -2.8 -2.9
Allergy or Eczema 1.7 4.5 11.3 -0.6 1.1 0.6 0.3 3.0 -1.9 -1.1 1.7 2.7 -1.8 2.9 3.4 3.1
Cardiovascular Disease 1.1 3.6 9.7 0.1 1.0 -0.7 3.1 -2.5 1.7 -0.3 -1.5 -2.2 1.2 -2.0 -2.6 -2.5
Hypothyroidism (self reported) 0.2 0.5 3.4 -0.1 -0.9 -0.8 -1.9 -0.6 0.4 -0.7 -0.3 -0.4 0.1 -0.6 -0.6 -0.6
Respiratory disease 0.7 1.6 4.2 -0.0 1.0 2.0 0.9 1.7 -0.8 0.6 1.0 1.6 0.4 1.6 1.7 1.6
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.3 -0.1 -0.2 0.4 1.7 -1.2 1.1 1.0 -0.9 -1.3 1.0 -1.8 -1.8 -1.5
Lung FEV1/FVC ratio 1.7 8.6 18.5 -1.3 1.7 1.1 3.5 -2.9 4.2 -0.3 -4.2 -3.3 4.3 -2.7 -2.4 -2.6
Lung FVC 0.5 2.6 8.6 1.5 1.0 2.1 -0.1 0.5 -2.2 2.9 2.5 0.7 -2.4 0.6 -0.1 0.0
Neuroticism 0.3 0.7 4.2 -0.7 -2.1 -1.2 0.3 0.1 0.5 -1.3 -0.7 -0.1 0.7 0.2 0.4 0.2
Chronotype (morning person) 0.3 0.7 3.2 -1.2 -0.2 -0.7 0.4 0.8 -0.1 -1.8 0.1 1.0 -0.1 0.9 0.9 1.0
Hair Pigment 0.1 1.5 6.1 -2.5 -1.7 -1.6 0.7 -0.6 0.3 -2.1 -0.8 -0.7 0.2 -0.7 -0.7 -0.3
Tanning 0.1 1.3 5.0 1.4 2.1 0.1 1.3 0.8 -0.7 2.2 1.1 0.8 -0.7 -0.1 0.2 0.3
Hand grip strength (left) 0.9 2.3 6.7 -0.0 -1.9 -0.1 -0.7 1.6 -2.2 0.4 2.0 1.7 -2.6 0.8 1.4 1.5
Number of treatments/medications taken 1.3 2.4 5.4 -0.4 0.2 -0.8 2.3 -1.9 1.4 -0.5 -1.3 -2.0 1.0 -2.0 -2.1 -2.1
Average weekly spirits intake 0.3 0.4 0.8 -0.1 -0.9 0.3 0.1 0.8 -0.7 0.9 0.8 0.8 -0.2 0.2 0.4 0.6
Sensitivity / hurt feelings 0.2 0.4 2.5 -0.4 -0.7 -1.6 1.1 0.2 0.1 -0.1 -0.0 -0.0 0.5 0.0 0.2 0.0
Frequency of depressed mood in last 2 weeks 1.6 2.3 4.7 1.3 -1.7 -0.9 1.2 -1.8 0.9 0.5 -1.0 -2.0 -0.1 -2.2 -2.0 -2.2
Hearing difficulty/problems: Yes 0.2 0.4 1.4 0.3 -0.5 -0.6 -0.7 -0.5 0.5 -1.2 -0.6 -0.7 0.6 -0.2 -0.4 -0.5
Relative age of first facial hair 0.2 0.5 2.7 -0.8 0.1 -0.9 -0.2 -0.7 0.4 -1.7 -0.5 -0.5 -0.1 -0.2 -0.5 -0.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 2.0 -0.4 -0.2 -0.4 1.4 -0.4 0.4 -0.8 -0.3 -0.1 0.5 -0.2 -0.1 -0.2
Ever used hormone-replacement therapy (HRT) 1.4 1.8 5.1 1.3 1.2 2.0 2.3 -1.1 0.4 1.7 -0.2 -1.1 0.4 -1.3 -1.3 -1.3
Ever had hysterectomy (womb removed) 1.6 1.8 4.0 -1.9 -0.2 -0.2 0.9 -1.3 1.6 -1.7 -1.6 -1.3 2.0 -0.9 -1.0 -1.1
Systolic blood pressure, automated reading 0.5 1.5 5.9 0.0 0.8 0.7 2.4 -1.5 1.1 -0.1 -1.1 -1.3 1.1 -1.3 -1.2 -1.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.3 -0.5 0.8 1.7 0.0 0.2 -1.2 1.8 1.3 0.3 -1.2 -0.1 -0.0 0.0
Angina 0.1 0.2 0.9 0.2 -0.3 -1.0 -0.8 -0.1 -0.1 -0.2 0.3 0.3 0.1 -0.0 -0.1 -0.0
Medication for hormone replacement therapy 0.6 0.6 2.0 0.6 1.0 0.9 -0.5 0.8 -0.8 1.4 0.9 0.7 -0.3 0.5 0.6 0.6
Vitamin and mineral supplements 0.6 0.9 3.2 1.8 0.7 0.5 0.3 -1.2 0.8 0.3 -0.6 -1.0 0.7 -0.8 -1.0 -1.2
Supplements: Zinc 0.3 0.3 0.9 -0.0 0.2 -0.8 -0.8 -0.1 -0.5 0.6 0.5 0.1 -1.0 -0.7 -0.5 -0.3
Medication: Co-codamol 0.2 0.3 0.9 -0.0 1.0 0.3 -0.5 -0.6 0.1 0.1 -0.4 -0.8 -0.2 -0.6 -0.6 -0.6
Medication: Metformin 0.4 0.6 2.2 -1.0 0.3 0.1 1.5 -0.6 0.6 -0.1 -0.6 -0.8 0.9 -0.9 -0.8 -0.7
Diabetes (father) 1.1 1.4 4.1 -1.3 1.1 -0.2 2.0 -0.9 1.3 -0.6 -1.5 -1.1 1.5 -1.1 -0.6 -0.8
Diabetes (mother) 0.3 0.4 1.0 -0.5 -0.1 0.2 -1.0 0.6 -0.8 0.6 0.8 0.6 -0.8 -0.2 0.3 0.5
Severe depression (siblings) 0.7 0.8 2.4 -1.5 -1.5 -1.3 -1.6 0.5 -0.5 0.2 0.4 0.3 -0.5 0.4 0.4 0.3
Pack years adult smoking proportion 1.1 1.7 2.7 0.8 -1.4 0.0 1.6 -1.4 1.4 -0.7 -1.5 -1.4 1.6 -1.4 -1.3 -1.2
Impedance of leg (right) 0.5 2.5 8.5 -1.3 0.4 -1.2 1.1 -0.8 2.5 -2.0 -2.7 -1.1 2.9 0.4 0.1 -0.2
Leg fat-free mass (left) 0.7 3.7 14.6 1.5 -1.2 0.8 -1.4 0.9 -3.3 1.4 3.4 1.4 -3.8 -0.5 -0.0 0.4
Trunk fat percentage 0.8 3.2 10.7 3.3 1.5 2.1 0.9 -1.9 0.1 0.7 0.1 -1.4 -0.2 -2.4 -2.5 -2.1
Hand grip strength (right) 1.8 4.8 15.9 -0.8 -2.5 0.6 -0.9 2.0 -3.3 1.3 3.2 2.1 -4.0 1.2 1.5 1.7
Townsend deprivation index at recruitment 0.7 1.0 3.2 -0.3 0.1 0.6 0.9 -1.3 0.6 0.5 -0.6 -1.2 0.2 -1.8 -1.7 -1.5
Current tobacco smoking 3.3 5.5 10.2 0.5 1.6 0.3 1.2 -3.1 2.6 0.3 -2.6 -3.2 2.2 -2.9 -3.2 -3.2
Average weekly fortified wine intake 0.2 0.2 0.6 0.0 0.3 0.6 0.1 -0.8 -0.1 0.4 0.0 -0.8 -0.2 -0.7 -0.7 -0.7
Maternal smoking around birth 0.6 0.9 2.5 0.7 -0.8 -1.3 0.7 -0.9 1.0 -1.6 -1.1 -0.6 0.3 -1.0 -0.5 -0.8
Fed-up feelings 1.2 2.2 8.1 -0.5 -2.8 -1.6 0.5 -1.4 1.5 -1.5 -1.7 -1.6 1.3 -1.2 -1.2 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 9.1 0.9 -1.8 -0.8 1.4 -2.5 1.4 0.3 -1.3 -2.3 0.3 -3.0 -2.6 -2.7
Relative age voice broke 1.5 2.3 8.2 -0.1 -0.7 -0.9 0.8 -1.4 2.1 -2.9 -2.3 -1.5 2.0 -0.7 -0.6 -0.9
Taking other prescription medications 0.1 0.2 1.2 0.8 0.3 0.2 1.1 0.0 0.2 0.1 -0.2 -0.2 0.8 -0.1 -0.1 -0.0
Age when periods started (menarche) 0.6 1.5 6.5 -0.7 1.1 -0.4 2.5 -1.3 0.5 1.1 -0.4 -1.2 0.2 -1.5 -1.6 -1.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 2.0 -1.0 0.8 -0.1 -0.2 0.5 -0.3 -1.4 -0.0 0.4 0.2 0.5 0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.1 0.3 1.1 1.1 -1.1 1.3 -1.9 1.0 2.0 1.4 -2.0 0.5 0.7 0.8
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 8.1 1.1 1.6 2.8 0.3 -0.6 0.3 1.3 -0.1 -0.7 0.6 -0.3 -0.5 -0.6
Qualifications: CSEs or equivalent 0.7 1.0 7.5 1.7 2.7 0.8 -0.7 -0.1 -0.3 0.8 0.3 0.0 -0.3 -0.3 -0.3 -0.2
Serious illness, injury or assault to yourself 0.8 1.0 3.3 0.5 -1.1 0.5 0.5 0.6 -1.5 1.6 1.4 0.6 -1.8 -0.3 0.0 0.3
High blood pressure 1.5 4.3 11.5 -0.2 1.4 0.2 3.4 -2.7 1.8 0.1 -1.5 -2.4 1.2 -2.4 -2.8 -2.8
Hayfever, allergic rhinitis or eczema 2.4 5.1 11.8 -0.5 1.2 0.5 0.6 3.1 -2.4 -0.1 2.3 3.0 -2.1 3.0 3.4 3.2
Multivitamins +/- minerals 1.5 1.9 4.1 -1.6 -0.3 -0.6 -1.2 2.0 -1.3 0.2 1.2 1.8 -0.7 1.6 1.8 2.0
Stomach or abdominal pain in last month 0.9 1.1 3.6 -1.5 -1.0 -1.5 -0.1 0.9 -0.1 -1.9 -0.1 0.7 -0.2 1.0 1.2 1.1
Supplements: Glucosamine 0.5 0.6 1.4 -0.5 -0.2 0.5 1.2 0.9 -0.7 0.9 0.8 1.0 -0.3 0.7 0.8 0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 4.0 -1.1 0.8 0.5 2.0 0.6 0.1 -0.7 -0.0 0.8 0.2 1.2 1.0 0.8
Medication: Atenolol 4.6 5.8 12.0 1.5 -0.1 -0.8 2.4 -3.3 2.5 0.6 -2.1 -3.0 2.1 -3.0 -3.3 -3.5
Medication: Levothyroxine sodium 0.3 0.4 2.5 -1.0 -0.5 -0.9 -1.6 -0.5 -0.0 -0.6 0.0 -0.3 -0.4 -0.3 -0.4 -0.4
Sitting height 0.6 4.0 13.8 0.1 -1.9 -0.8 -2.0 1.7 -3.1 0.5 3.0 2.0 -3.7 0.9 1.2 1.3
Chronic bronchitis/emphysema (father) 0.5 0.6 1.9 0.0 -1.1 -0.6 -0.9 0.9 -0.4 -1.4 0.1 0.6 -0.4 0.6 0.9 1.0
High blood pressure (mother) 0.3 0.4 2.0 1.4 0.7 -0.4 0.8 -0.2 -0.3 1.1 0.5 -0.1 -0.3 -0.2 -0.5 -0.4
Body mass index (BMI) 0.4 1.9 7.2 2.7 1.0 1.7 0.5 -1.2 -0.4 0.6 0.5 -0.9 -0.8 -2.0 -1.9 -1.5
Impedance of leg (left) 0.5 2.6 7.7 -1.1 0.2 -1.3 0.8 -1.0 2.6 -2.3 -2.8 -1.3 2.8 0.1 -0.1 -0.4
Leg predicted mass (left) 0.7 3.9 15.1 1.5 -1.2 0.8 -1.3 1.0 -3.4 1.5 3.5 1.5 -3.9 -0.4 0.0 0.4
Trunk fat mass 0.7 3.1 11.8 3.4 1.0 2.3 0.6 -1.4 -0.8 1.4 1.0 -0.9 -1.3 -2.4 -2.3 -1.9
Waist circumference 0.7 2.4 8.5 2.9 1.6 1.2 1.8 -1.4 -0.1 0.8 0.3 -1.1 -0.3 -2.1 -2.1 -1.7
Number of incorrect matches in round 0.4 0.6 2.0 -0.5 -0.8 -1.4 -0.4 -0.9 0.4 -1.4 -0.5 -0.7 0.1 -0.5 -0.9 -0.8
Past tobacco smoking 0.7 1.3 2.9 -1.6 -0.8 -1.3 0.1 1.1 0.1 -1.1 -0.2 1.2 0.9 1.7 1.6 1.5
Alcohol usually taken with meals 0.7 1.1 5.7 0.5 0.4 1.2 0.8 0.3 -1.3 2.4 1.5 0.3 -1.5 -0.1 -0.3 -0.2
Nervous feelings 0.3 0.6 2.9 -0.5 -0.7 -0.5 0.6 0.2 0.4 -1.7 -0.5 0.2 0.8 0.9 0.9 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.1 0.0 -1.4 -1.2 0.7 0.3 -0.9 -0.8 0.6 0.2 -1.5 0.1 0.4 0.1
Hearing difficulty/problems with background noise 0.7 1.1 5.2 -0.7 -0.8 -1.4 -0.4 0.8 -0.1 -2.3 -0.2 0.5 0.4 1.3 1.4 1.1
Hair/balding pattern: Pattern 2 1.0 1.2 2.5 1.0 0.3 -0.8 1.5 -1.6 0.8 -0.0 -0.8 -1.4 0.3 -1.5 -1.3 -1.5
Had menopause 1.7 2.1 6.0 1.8 -0.6 1.8 2.4 -1.0 1.5 0.7 -1.4 -1.2 1.9 -1.1 -0.9 -1.0
Had other major operations 1.2 1.4 6.0 -0.8 0.2 -0.5 -1.2 1.0 -0.4 -2.4 0.1 1.0 -0.1 1.9 1.5 1.4
Forced vital capacity (FVC) 1.8 7.0 19.3 1.1 -0.6 0.8 -1.1 2.5 -4.2 2.4 4.3 2.9 -4.4 2.0 1.9 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 4.6 0.6 0.5 0.5 -2.1 1.2 -1.6 0.1 1.5 1.3 -1.8 0.7 0.8 1.0
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.0 0.2 1.4 1.1 0.6 0.6 -1.0 -0.2 1.0 0.7 -1.4 0.5 0.7 0.7
Qualifications: None of the above 0.8 1.7 3.2 -0.1 -0.4 1.1 1.2 -1.5 1.7 -0.7 -1.7 -1.4 1.8 -1.3 -1.4 -1.3
Financial difficulties in last 2 years 2.3 3.1 6.0 2.0 -0.6 -1.8 0.2 -2.2 1.5 0.6 -1.5 -2.1 0.4 -2.4 -2.5 -2.4
Mouth/teeth dental problems 1.0 1.5 4.7 1.1 1.1 1.0 0.6 1.4 -1.2 2.2 1.3 1.3 -0.9 0.9 1.1 1.3
Heart attack 0.8 1.0 2.3 1.5 1.5 -0.0 0.8 -0.9 0.6 0.5 -0.6 -1.1 0.6 -1.2 -1.1 -1.2
Allergy 2.3 5.3 10.5 -0.0 -1.4 -0.7 -0.4 -3.2 2.7 -0.6 -2.7 -3.1 2.2 -2.6 -3.2 -3.0
Pain all over the body in last month 0.4 0.4 2.5 -1.1 -0.1 -1.6 0.4 0.5 -0.1 -1.0 -0.1 0.3 -0.2 0.3 0.3 0.6
Diabetes (self-reported) 1.1 1.7 4.6 -0.9 -0.4 0.1 2.1 -1.3 1.2 0.7 -1.1 -1.4 1.1 -1.9 -1.7 -1.5
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.5 0.7 -0.1 1.2 0.1 1.5 -1.5 0.9 1.6 1.5 -1.4 1.1 1.1 1.3
Medication: Ramipril 0.7 0.9 1.8 -0.3 -0.7 0.5 0.9 -1.2 1.0 -0.6 -1.0 -1.3 0.7 -0.8 -1.2 -1.3
Medication: Simvastatin 1.2 1.8 4.0 2.0 1.5 0.9 1.6 -1.3 0.3 1.4 -0.0 -1.1 -0.1 -1.6 -1.8 -1.6
Fluid intelligence score 0.6 1.2 2.0 -1.4 -0.8 0.5 -0.4 1.2 -1.1 0.7 1.2 1.3 -1.0 1.3 1.4 1.2
Illnesses of siblings 3.3 4.7 9.3 -0.4 -1.8 -1.2 -3.0 2.4 -2.4 -1.2 2.0 2.3 -2.5 2.5 2.5 2.5
Neuroticism score 0.4 0.8 3.2 -0.8 -1.8 -1.5 0.5 0.2 0.3 -1.5 -0.6 -0.1 0.5 0.1 0.4 0.2
Weight 0.5 2.5 7.5 2.7 -0.2 1.6 0.1 -0.3 -2.1 1.1 2.2 0.2 -2.7 -1.5 -1.2 -0.8
Impedance of arm (right) 0.4 1.8 5.7 -0.0 0.5 0.3 1.9 -1.4 2.1 -0.0 -2.0 -1.3 2.4 -0.4 -0.8 -1.1
Arm fat percentage (right) 1.2 4.6 12.1 3.5 1.7 2.4 1.5 -2.3 0.6 1.4 -0.4 -2.0 0.2 -2.9 -3.0 -2.6
Trunk fat-free mass 0.8 4.7 18.0 0.5 -1.8 0.2 -1.2 1.7 -3.7 1.2 3.7 2.1 -4.2 0.4 0.9 1.2
Hip circumference 0.4 1.5 7.1 2.7 0.7 0.8 0.6 -0.6 -1.3 0.4 1.3 -0.2 -1.8 -1.4 -1.2 -0.9
Time employed in main current job 1.5 1.7 4.1 0.1 0.4 0.6 0.9 -1.9 1.2 -0.9 -1.3 -1.7 0.8 -1.6 -2.0 -1.7
Alcohol intake versus 10 years previously 0.8 1.2 2.7 -0.3 0.8 0.7 0.4 -1.6 1.0 -0.2 -0.8 -1.4 0.8 -1.4 -1.6 -1.6
Father’s age at death 0.3 0.4 1.7 -0.1 -0.4 -0.4 -0.3 0.5 0.7 -0.2 -0.9 0.2 1.3 0.7 0.8 0.7
Worrier / anxious feelings 1.4 2.6 11.6 -1.7 -2.8 -3.4 0.0 0.5 0.3 -2.7 -0.7 0.3 0.5 1.0 0.9 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 7.5 1.1 -0.3 0.2 2.7 -1.2 0.2 0.8 -0.1 -1.0 0.1 -1.0 -1.2 -1.3
Falls in the last year 0.3 0.4 1.3 -0.5 0.4 1.0 0.1 -0.6 0.4 0.0 -0.7 -0.8 0.2 -1.1 -0.7 -0.7
Hair/balding pattern: Pattern 3 1.2 1.7 7.4 2.3 1.4 2.5 -0.0 0.4 -0.6 2.7 0.8 0.2 -0.3 -0.6 -0.2 -0.1
Number of live births 0.4 0.5 1.4 -1.0 0.6 1.0 1.2 0.0 -0.4 0.1 0.4 -0.2 -1.0 -0.9 -0.7 -0.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 7.5 0.9 -0.4 0.7 -0.3 1.2 -2.4 1.7 2.4 1.4 -2.7 0.9 1.0 1.0
Pulse rate 0.2 0.4 0.8 0.8 0.9 0.9 0.6 -0.4 -0.1 0.2 -0.1 -0.5 -0.6 -0.5 -0.8 -0.5
Happiness 1.2 1.4 4.0 0.0 -1.0 -1.7 -0.2 -1.2 1.3 -2.0 -1.5 -1.4 0.6 -0.9 -1.0 -1.1
Noisy workplace 0.6 0.7 3.0 -0.2 1.7 0.8 -0.3 0.8 -1.0 -0.3 1.0 1.0 -0.9 0.8 0.6 0.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.9 -1.2 -0.9 -1.2 -0.8 0.6 -0.3 -0.9 0.3 0.7 0.1 1.2 1.4 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 3.2 -0.8 -0.6 -0.9 -0.6 -1.2 1.6 -1.3 -1.4 -0.8 1.8 -0.1 -0.3 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.5 1.6 1.0 0.7 1.3 -0.3 -0.7 -0.0 0.3 0.2 -0.6 -0.1 -0.8 -1.1 -1.0
Asthma 1.0 2.0 3.9 -0.1 2.0 1.4 1.3 1.7 -1.1 0.3 1.2 1.7 -0.4 1.8 1.9 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 4.8 -0.3 0.4 -2.2 0.6 -1.8 1.2 -1.0 -1.3 -1.8 0.7 -1.7 -1.7 -1.7
Medication: Cholesterol lowering 0.4 0.5 1.4 0.8 0.7 -0.1 1.2 -0.5 0.5 1.1 -0.2 -0.5 0.8 -0.6 -0.9 -0.8
Depression (self-reported) 0.9 1.1 2.5 -0.4 -0.4 -0.4 -0.6 1.2 -1.1 0.7 1.4 1.4 -0.3 1.5 1.6 1.1
Medication: Lansoprazole 3.4 3.8 6.8 -0.5 0.3 -2.1 1.9 -2.3 2.3 -2.0 -2.6 -2.4 1.5 -2.1 -1.9 -2.1
Prospective memory result 0.2 0.2 0.6 0.1 -0.3 -0.4 -0.7 -0.5 0.1 -0.8 -0.2 -0.4 -0.1 -0.6 -0.5 -0.6
Lung cancer (father) 2.1 2.5 4.0 -2.0 -1.6 -1.0 -1.4 1.9 -1.4 -0.5 1.4 1.8 -0.9 1.8 1.9 2.0
Illnesses of mother 0.5 0.6 2.3 -1.5 0.2 -0.1 -1.0 0.3 0.6 -1.0 -0.6 0.3 1.1 0.8 0.6 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 7.0 -0.4 -0.5 0.5 -0.6 1.8 -2.5 1.2 2.5 1.9 -2.6 1.8 1.7 1.7
Pulse wave Arterial Stiffness index 0.5 0.6 2.2 0.4 -0.7 -0.7 -1.5 -0.8 0.2 -0.7 -0.2 -0.8 -0.3 -1.1 -1.1 -0.8
Impedance of arm (left) 0.1 0.5 2.6 -0.3 0.2 -0.0 1.1 -0.5 1.1 0.0 -1.0 -0.4 1.6 0.3 -0.1 -0.2
Arm fat mass (right) 0.6 2.5 9.3 3.1 0.8 2.0 0.5 -1.2 -0.9 1.0 1.0 -0.7 -1.4 -2.1 -2.0 -1.6
Trunk predicted mass 0.9 4.9 18.3 0.5 -1.8 0.2 -1.3 1.8 -3.7 1.2 3.8 2.1 -4.3 0.5 1.0 1.2
Standing height 0.7 6.8 22.7 0.1 -3.0 -0.2 -1.0 2.2 -4.3 1.3 4.3 2.6 -4.8 1.1 1.5 1.6
Length of working week for main job 0.4 0.5 2.1 -0.4 0.5 0.2 0.4 0.7 -0.4 0.2 0.6 0.9 -0.1 1.4 1.0 0.7
Exposure to tobacco smoke at home 1.4 1.6 3.3 -1.0 -0.9 -0.4 -0.6 1.8 -1.5 0.2 1.6 1.6 -0.9 1.1 1.5 1.7
Breastfed as a baby 2.2 2.7 7.2 1.0 1.5 2.7 -0.6 1.4 -2.1 1.5 2.2 1.3 -2.1 1.6 1.0 1.1
Tense / ‘highly strung’ 0.3 0.4 1.8 -0.9 -1.0 -1.3 -0.6 0.3 0.3 -1.0 -0.4 0.1 0.4 -0.0 0.3 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.3 -0.7 -0.4 -1.2 -0.4 0.4 -0.4 -0.2 0.2 0.2 -0.5 0.2 0.4 0.4
Hair/balding pattern: Pattern 4 1.4 3.3 14.2 -3.4 -2.6 -3.8 -0.9 0.9 -0.2 -2.4 -0.2 0.6 0.0 0.9 1.0 1.0
Birth weight of first child 0.1 0.1 0.4 0.6 0.1 0.6 -0.1 0.2 -0.1 -0.1 0.2 0.3 -0.5 -0.0 0.1 0.1
Peak expiratory flow (PEF) 0.1 0.2 1.3 0.7 -1.1 -0.2 -0.3 -0.1 -0.0 -0.5 -0.2 -0.2 -0.4 -0.4 0.1 0.0
Pulse wave reflection index 0.5 0.6 2.9 -0.6 -1.2 -0.1 -1.7 0.4 -0.9 0.8 1.0 0.3 -0.7 -0.0 0.1 0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.4 1.0 0.5 1.0 1.5 -1.1 1.2 0.6 -1.0 -1.0 1.2 -0.9 -1.1 -1.2
Loud music exposure frequency 0.7 0.8 4.1 1.0 -2.0 0.3 -0.9 0.7 -0.9 -0.3 0.8 0.7 -1.1 0.5 0.5 0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.5 -0.1 -0.4 -0.5 -1.0 -0.6 0.0 1.2 0.3 -0.4 -0.3 -0.3 -0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 9.4 -1.6 -2.6 -3.1 -1.2 -0.9 0.9 -2.2 -1.1 -0.8 0.7 -0.4 -0.2 -0.6
Blood clot in the leg (DVT) 0.4 0.5 1.7 0.8 0.4 -0.2 -0.4 0.5 -0.9 1.3 1.1 0.7 -0.6 -0.2 0.1 0.3
Medication: Paracetamol 0.6 1.0 2.6 -0.8 0.6 0.0 -0.3 -1.1 -0.3 -0.9 -0.2 -1.4 -0.9 -1.6 -1.6 -1.3
Headache pain in last month 0.5 0.8 2.1 -0.3 -1.5 -0.5 -1.3 0.5 -1.2 1.2 1.1 0.3 -1.4 -0.1 -0.1 0.1
Medication for cholesterol, blood pressure or diabetes 1.5 2.6 5.1 -0.3 -0.6 0.4 -2.3 1.9 -1.7 -1.2 1.2 1.7 -1.6 1.7 2.2 2.2
Glaucoma (self-reported) 0.4 0.5 2.0 0.1 -0.4 1.2 1.4 0.1 0.8 0.9 -0.6 -0.1 1.1 0.1 0.2 -0.0
Gout (self-reported) 0.4 0.5 2.6 1.6 0.4 0.8 -0.1 -0.5 -0.3 0.8 0.5 -0.1 -0.5 -0.6 -0.8 -0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 4.4 -1.2 -1.4 -0.7 -2.1 -0.2 -0.1 -0.8 -0.0 -0.1 -0.5 -0.2 -0.4 -0.1
Medication: Amlodipine 3.5 4.9 8.1 0.4 1.9 0.5 2.8 -2.7 2.8 -0.6 -2.8 -2.7 2.0 -2.3 -2.4 -2.6
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.9 0.3 0.4 0.8 0.1 2.0 -1.2 -0.4 1.3 2.0 -0.9 1.9 1.9 1.8
Birth weight 0.5 1.2 2.3 1.4 -0.8 1.4 -0.8 0.7 -1.5 1.0 1.5 0.8 -1.5 0.7 0.2 0.6
Chronic bronchitis/emphysema (mother) 1.5 1.7 5.5 -0.6 -1.1 -2.0 -0.9 1.2 -1.7 -0.8 1.4 1.0 -2.4 0.6 1.1 1.0
High blood pressure (siblings) 1.6 2.3 5.4 1.2 2.1 2.1 2.0 -1.1 1.0 2.3 -0.6 -1.1 1.0 -1.2 -1.4 -1.4
Forced vital capacity (FVC), Best measure 1.9 6.8 16.3 -0.2 -0.7 0.8 -1.2 2.8 -3.9 1.8 4.0 3.0 -4.0 2.6 2.4 2.5
Body fat percentage 1.1 4.3 11.3 3.4 1.6 2.1 0.9 -2.4 0.7 0.6 -0.6 -2.0 0.3 -3.0 -3.0 -2.7
Leg fat percentage (right) 1.5 5.6 12.2 2.7 1.5 1.5 1.5 -3.1 1.9 0.1 -1.8 -2.8 1.3 -3.4 -3.5 -3.1
Arm fat-free mass (right) 0.8 4.1 17.4 1.0 -1.1 0.2 -1.8 1.3 -3.6 0.7 3.5 1.7 -4.2 -0.1 0.4 0.8
Exposure to tobacco smoke outside home 1.0 1.3 3.0 -0.4 -0.3 0.5 1.0 -1.5 1.0 1.0 -0.6 -1.2 1.1 -1.6 -1.7 -1.7
Comparative body size at age 10 1.7 4.8 10.7 -0.0 -1.5 0.8 -1.1 2.6 -3.1 0.6 3.3 3.0 -2.9 1.9 2.1 2.4
Number of full brothers 0.2 0.3 1.4 0.3 1.2 0.2 -1.2 0.1 0.2 -0.2 -0.1 0.1 0.3 0.4 0.1 0.1
Worry too long after embarrassment 0.5 0.8 3.6 0.1 -1.9 -0.9 -0.3 0.9 -0.9 -0.0 0.8 0.6 -1.0 0.8 1.1 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 4.6 6.0 11.9 0.1 0.3 0.5 -0.4 3.5 -3.1 1.6 3.1 3.3 -2.2 2.8 3.1 3.3
Wheeze or whistling in the chest in last year 0.4 0.7 5.5 0.4 0.2 1.6 2.4 -0.4 0.3 0.1 -0.0 -0.3 0.4 -0.4 -0.4 -0.6
Number of children fathered 0.3 0.3 1.1 -0.8 1.0 0.3 -0.1 0.4 0.5 -0.2 -0.3 0.4 0.8 0.6 0.3 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 4.4 -1.6 -0.8 -2.1 0.2 1.4 -0.7 -1.0 0.6 1.3 -0.7 1.1 1.4 1.3
Age at first live birth 1.4 2.4 5.5 0.5 -0.2 -1.1 -0.0 -1.9 2.3 -2.3 -2.4 -1.8 1.9 -0.8 -0.9 -1.3
Pulse wave peak to peak time 0.6 0.7 2.8 -0.4 0.5 0.7 1.7 0.8 -0.3 0.7 0.4 0.8 0.0 1.1 1.1 0.8
Health satisfaction 1.2 1.6 4.9 2.2 1.3 -0.3 1.5 -0.8 1.5 -1.4 -1.5 -0.9 1.7 -0.2 -0.5 -0.6
Shortness of breath walking on level ground 1.5 1.8 6.1 2.5 1.2 1.3 1.3 -1.5 1.2 -0.5 -1.1 -1.4 1.5 -0.8 -1.2 -1.3
Qualifications: College or University degree 0.6 1.9 7.5 -1.2 -0.6 -1.5 -2.7 1.1 -1.1 -0.6 1.1 1.2 -1.1 1.6 1.5 1.3
Eye problems/disorders: None of the above 0.3 0.3 1.8 -0.1 -0.6 -1.3 -1.1 -0.1 0.3 -0.5 -0.3 0.1 0.1 0.3 0.0 0.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 -1.4 -1.6 -0.6 0.2 -1.3 1.6 -0.6 -1.5 -1.2 1.4 -0.9 -1.0 -1.1
Emphysema/chronic bronchitis 0.3 0.3 1.5 -1.0 -1.2 0.2 -0.1 -0.3 -0.4 0.4 0.5 -0.2 -0.3 -0.6 -0.6 -0.5
Medication for pain relief, constipation, heartburn 2.6 4.4 11.6 0.5 -0.6 0.3 -1.9 2.9 -1.4 -0.1 1.5 3.0 -0.6 3.2 3.4 3.1
Neck or shoulder pain in last month 0.3 0.4 2.1 0.0 1.1 0.2 1.5 0.4 -0.4 -0.4 -0.1 -0.2 -0.7 0.0 0.4 0.2
Medication: Blood pressure 3.4 6.0 12.9 0.2 0.3 0.1 2.5 -3.2 2.6 1.7 -2.1 -3.0 1.9 -3.0 -3.6 -3.6
Angina (self-reported) 0.1 0.2 0.9 0.4 -0.3 -1.0 -0.8 0.1 -0.3 -0.1 0.5 0.5 -0.1 0.0 0.0 0.1
Migraine (self-reported) 2.3 2.9 4.9 -0.1 -1.1 0.2 -1.8 2.2 -2.2 0.1 2.1 2.1 -1.9 1.9 1.7 2.1
Medication: Ibuprofen 1.1 1.3 6.5 -0.6 0.1 -2.5 -0.0 -1.3 1.0 -1.3 -1.1 -1.2 0.4 -1.0 -1.1 -1.1
Medication: Allopurinol 0.5 0.7 1.9 1.0 0.1 1.2 -0.1 -0.3 -0.8 1.4 1.1 0.2 -1.0 -0.6 -0.8 -0.4
Medication: Omeprazole 0.8 0.9 1.6 -1.3 -0.8 -0.9 0.4 0.9 -1.1 -1.0 0.9 0.8 -0.7 1.1 1.2 1.1
Medication: Seretide 50 evohaler 0.6 0.7 2.3 0.3 1.0 0.8 1.4 0.1 1.0 -0.6 -0.9 -0.0 1.5 0.4 0.4 0.2
Mean time to correctly identify matches 1.5 2.8 5.4 -0.7 -1.5 -0.0 0.9 2.3 -2.2 0.1 2.1 2.2 -1.2 1.7 2.0 2.3
Heart disease (mother) 2.5 3.0 4.8 0.9 0.6 -0.5 1.8 -2.2 2.0 -0.4 -1.9 -2.1 2.0 -2.2 -2.1 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.3 -0.1 -0.7 0.2 -1.3 1.3 -1.0 -0.3 0.6 1.0 -1.3 1.5 1.5 1.3
Whole body fat mass 0.7 2.8 10.5 3.2 0.6 2.1 0.6 -1.5 -0.5 0.9 0.6 -1.1 -0.9 -2.5 -2.4 -1.9
Leg fat mass (right) 0.6 2.5 7.1 2.7 0.2 1.3 0.6 -1.8 0.0 0.5 0.0 -1.4 -0.6 -2.6 -2.5 -2.0
Arm predicted mass (right) 0.7 3.4 15.0 0.9 -1.4 -0.1 -1.5 1.0 -3.2 0.7 3.2 1.4 -3.9 -0.4 0.2 0.5
Pulse rate, automated reading 0.3 0.8 2.4 1.5 1.1 1.1 -0.5 0.5 -1.1 0.9 1.1 0.5 -1.3 0.3 -0.1 0.3
Alcohol intake frequency. 0.4 0.9 1.5 -0.3 -0.1 -0.1 1.2 -1.2 1.1 -1.1 -1.2 -1.1 0.9 -0.8 -1.0 -1.1
Comparative height size at age 10 1.3 7.3 21.1 0.5 -1.2 1.6 -1.9 2.7 -4.4 1.1 4.4 3.2 -4.6 1.3 1.7 2.1
Number of full sisters 0.2 0.3 0.7 -0.7 0.8 0.2 -0.8 -0.2 0.3 -0.6 -0.5 -0.4 0.8 -0.4 -0.4 -0.3
Suffer from ‘nerves’ 0.4 0.6 1.4 -0.4 -0.9 -0.7 -0.1 0.8 -0.5 -1.2 0.4 0.7 -0.3 1.0 1.1 0.8
Overall health rating 1.2 2.5 4.2 1.2 0.8 0.1 2.0 -1.8 1.8 -0.7 -1.8 -1.7 2.0 -1.6 -1.9 -1.8
Chest pain or discomfort 0.5 0.8 2.5 -1.0 -0.4 -0.5 -0.1 1.0 -0.4 -0.9 0.5 1.1 -0.0 1.6 1.3 1.0
Had major operations 1.4 1.6 7.4 2.7 1.0 0.6 -0.3 0.7 -1.4 2.3 1.6 0.7 -1.2 -0.2 -0.1 0.3
Age at last live birth 0.9 1.3 2.8 0.2 -0.1 -0.0 0.9 -1.7 1.4 -0.5 -1.4 -1.6 1.0 -1.3 -1.4 -1.4
Family relationship satisfaction 0.1 0.1 0.9 -0.2 0.1 0.3 -0.2 -0.2 -0.2 0.9 0.2 -0.3 -0.7 -0.1 -0.4 -0.2
Leg pain on walking 0.7 0.9 6.8 0.6 1.3 -1.3 -0.4 -0.1 0.6 -2.6 -0.7 -0.0 0.6 0.3 0.3 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 9.5 -3.1 -0.6 -0.7 -0.7 1.6 -1.0 -2.0 0.6 1.3 -1.0 1.4 1.8 1.7
Commuting to job workplace: Car/motor vehicle 1.9 2.2 4.3 -0.8 -0.6 -1.7 1.0 -2.1 1.8 -0.8 -1.6 -1.6 1.5 -1.4 -1.9 -1.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.1 -1.2 0.0 0.1 0.1 1.3 -0.3 -1.5 0.1 1.0 0.3 0.8 1.4 1.4
Medication: Aspirin 6.5 8.6 15.4 0.8 0.9 0.7 3.3 -3.7 3.2 0.7 -2.9 -3.6 3.0 -3.5 -3.9 -3.8
Supplements: Vitamin C 0.2 0.3 1.1 -0.9 0.4 -0.3 1.0 -0.2 -0.3 -0.8 -0.1 -0.4 -0.6 -0.3 -0.1 -0.1
Knee pain experienced in last month 0.7 1.0 3.1 1.7 0.7 0.7 0.9 -1.0 1.2 -0.8 -1.2 -0.9 1.2 -0.6 -0.6 -0.8
Hypertension (Self-reported) 1.6 4.4 10.9 0.1 1.1 0.1 3.3 -2.9 2.0 0.1 -1.6 -2.5 1.4 -2.4 -2.8 -2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 3.3 -0.8 -1.2 -1.8 0.6 0.0 0.1 -1.5 -0.4 -0.2 -0.3 -0.1 0.1 -0.0
Illnesses of father: Heart disease 1.3 1.8 7.8 -1.3 -0.9 -2.8 0.7 -1.5 1.3 -0.9 -1.3 -1.3 0.8 -0.9 -1.0 -1.4
Illnesses of siblings: Diabetes 0.5 0.6 1.2 -0.0 0.6 0.3 0.1 -0.9 1.1 0.2 -1.0 -1.0 1.1 -1.0 -0.8 -1.0
Smoking status: Previous 0.5 0.7 3.0 1.1 0.7 1.7 -0.3 -0.2 -0.8 1.1 0.9 -0.2 -1.2 -0.5 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 12.4 0.6 -0.8 -0.8 -1.8 1.7 -3.2 0.2 3.2 2.2 -3.5 1.7 1.6 1.5
Whole body fat-free mass 0.8 4.5 17.8 0.9 -1.6 0.3 -1.4 1.5 -3.7 1.2 3.7 1.9 -4.2 0.1 0.6 0.9
Leg fat-free mass (right) 0.7 4.0 16.0 1.3 -1.5 0.5 -1.5 1.1 -3.4 1.2 3.4 1.6 -4.0 -0.3 0.1 0.5
Arm fat percentage (left) 0.9 3.7 10.5 3.2 1.6 2.2 1.0 -2.0 0.3 1.4 -0.0 -1.7 -0.1 -2.7 -2.8 -2.4
Average weekly red wine intake 0.5 0.7 1.5 -1.2 0.8 0.5 0.4 1.1 -0.3 0.1 0.3 1.0 0.1 1.1 1.2 1.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -0.8 -0.7 -1.1 0.1 0.5 -0.9 -1.0 0.7 0.5 -0.8 0.1 0.5 0.6
Mood swings 0.3 0.5 2.1 0.0 -1.0 0.1 1.5 -0.4 0.4 -1.1 -0.8 -0.7 0.5 -0.7 -0.1 -0.3
Loneliness, isolation 1.8 2.5 4.5 0.3 -1.3 -1.1 0.7 -2.0 2.0 0.3 -1.9 -2.1 1.6 -1.7 -1.8 -2.1
Long-standing illness, disability or infirmity 1.3 2.0 3.7 0.5 0.6 -1.2 1.9 -1.3 1.8 -1.8 -1.9 -1.4 1.9 -1.1 -0.8 -1.1
Ever had bowel cancer screening 0.8 1.0 3.4 1.1 1.8 1.5 0.4 -0.5 0.1 1.7 0.2 -0.3 0.3 -0.8 -1.0 -0.8
Diabetes diagnosed by doctor 0.7 1.2 3.7 -1.1 -0.2 0.2 1.9 -0.9 0.8 0.9 -0.7 -1.0 0.9 -1.7 -1.4 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.2 0.2 0.8 1.1 0.4 -0.9 0.5 1.0 -0.3 -0.7 -0.0 -0.8 -1.1 -1.1
Friendships satisfaction 0.3 0.3 0.7 -0.8 -0.3 -0.4 -0.5 0.6 -0.5 -0.5 0.2 0.5 -0.8 0.7 0.5 0.6
Qualifications: nursing, teaching 1.3 2.0 4.9 -1.1 -2.2 -2.2 -2.2 0.6 -0.8 -1.9 0.5 0.6 -1.4 1.2 1.1 0.8
Commuting to job workplace: Walk 0.9 0.9 2.8 0.8 -0.8 -0.3 -1.7 1.1 -0.6 -0.9 0.4 0.9 -0.5 1.3 1.2 1.2
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.7 -0.1 0.6 0.4 -0.4 -0.2 0.3 0.2 -0.4 -0.4 -0.7 -0.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.0 -0.6 -0.1 0.3 -0.2 0.5 -0.6 -0.7 0.6 0.8 -0.4 1.0 0.7 0.6
Medication for cholesterol 2.3 3.5 6.9 -0.6 -1.5 -0.9 -1.8 2.6 -1.9 0.2 1.8 2.5 -1.5 2.1 2.4 2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 6.2 1.3 0.8 2.5 0.0 -0.7 1.0 0.2 -1.0 -0.8 1.1 -0.8 -0.8 -0.6
Back pain experienced in last month 0.8 1.2 2.8 0.5 1.7 1.5 1.7 -0.9 0.8 0.5 -0.8 -0.9 0.9 -1.1 -0.9 -1.0
Mineral and other dietary supplements 0.5 0.7 2.2 1.5 0.4 0.6 -0.7 -0.9 0.9 -0.1 -0.7 -0.7 1.0 -0.6 -0.7 -0.9
Breast cancer (self-reported) 0.8 0.9 4.3 -1.1 -1.0 -2.1 -0.6 -0.8 0.6 -1.6 -0.7 -0.8 0.1 -0.3 -0.5 -0.6
Asthma (self-reported) 1.1 2.2 4.7 -0.1 1.9 1.4 1.3 1.9 -1.0 0.3 1.2 1.8 -0.2 2.1 2.2 1.7
Osteoporosis (self-reported) 1.8 2.2 4.8 -1.6 -1.1 -1.8 -1.8 1.5 -0.9 -1.0 0.8 1.5 -0.4 2.2 1.8 1.8
Osteoarthritis (self-reported) 5.0 6.5 13.2 2.0 1.1 0.0 1.6 -3.6 2.6 0.8 -2.2 -3.1 2.0 -3.4 -3.6 -3.6
Medication: Aspirin 5.4 7.1 14.4 0.6 0.7 0.8 2.8 -3.5 2.7 0.8 -2.5 -3.4 2.1 -3.5 -3.8 -3.7
Medication: Gliclazide 1.5 1.7 4.1 -0.1 -0.8 -0.7 1.3 -1.8 0.9 0.7 -0.8 -1.6 0.6 -2.0 -1.8 -1.9
Illnesses of father: None of the above (group 1) 1.8 2.2 4.1 0.9 0.7 1.8 -1.2 1.6 -2.0 1.2 2.0 1.6 -1.9 1.1 1.3 1.4
Smoking status: Current 3.6 5.7 10.9 0.5 1.6 0.1 1.5 -3.1 2.5 0.4 -2.5 -3.3 2.1 -3.1 -3.3 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.8 -0.6 -1.3 0.4 0.3 0.7 -0.5 0.4 0.4 0.5 -0.2 0.7 0.8 0.8
Whole body water mass 0.8 4.5 18.2 1.0 -1.5 0.3 -1.4 1.3 -3.7 1.3 3.7 1.8 -4.3 -0.1 0.4 0.8
Leg predicted mass (right) 0.8 4.0 16.0 1.4 -1.5 0.6 -1.5 1.0 -3.4 1.3 3.5 1.5 -4.0 -0.4 0.1 0.5
Arm fat mass (left) 0.6 2.3 8.7 3.0 0.8 1.8 0.3 -1.0 -1.0 1.1 1.2 -0.6 -1.5 -2.0 -1.9 -1.4
Number of self-reported non-cancer illnesses 1.0 1.7 11.3 0.7 0.6 0.5 3.4 -0.9 0.7 0.9 -0.4 -0.8 0.8 -1.5 -1.5 -1.3
Average weekly champagne plus white wine intake 0.5 0.7 2.4 0.0 -1.6 -1.2 -1.2 0.7 -0.4 -0.8 0.3 0.5 -0.2 0.9 0.8 0.7
Miserableness 0.4 0.7 3.0 0.2 -1.7 0.6 1.0 -0.8 0.7 -0.2 -0.8 -0.9 0.8 -0.9 -0.7 -0.8
Guilty feelings 1.9 2.8 13.5 -2.3 -3.7 -3.3 -1.2 0.3 -0.2 -2.1 -0.2 0.0 -0.5 0.4 0.3 0.3
Wears glasses or contact lenses 0.3 0.3 1.6 0.5 0.8 1.3 -0.5 0.4 -0.1 0.1 0.3 0.3 0.4 0.7 0.5 0.4
Ever taken oral contraceptive pill 0.1 0.1 0.5 -0.1 -0.5 0.2 -0.2 -0.3 0.1 0.7 0.1 0.1 0.1 0.3 0.0 -0.1
Hearing aid user 0.7 0.8 2.1 0.3 0.6 0.6 0.4 -1.3 0.5 0.2 -0.4 -1.3 0.6 -1.2 -1.3 -1.4
Mother’s age at death 0.2 0.2 1.2 1.1 0.2 0.8 0.6 0.2 -0.2 0.7 0.2 0.0 -0.5 -0.1 -0.0 -0.0
Financial situation satisfaction 0.7 0.9 5.3 2.3 1.4 0.2 0.6 -0.7 -0.3 0.0 0.1 -0.7 -0.8 -0.8 -0.8 -0.9
Tinnitus: Yes, now most or all of the time 1.3 1.6 5.4 -0.1 0.0 -1.9 -2.3 1.3 -1.0 0.1 1.1 1.4 -0.5 1.2 1.3 1.4
Commuting to job workplace: Public transport 1.4 1.7 7.0 1.5 1.9 2.7 0.4 1.0 -0.7 1.9 0.9 0.8 -0.1 0.9 1.0 0.6
Eye problems/disorders: Glaucoma 1.2 1.4 6.8 -0.6 0.4 1.3 1.9 -0.5 1.8 0.4 -1.5 -0.6 2.6 -0.0 0.0 -0.4
Medication: Blood pressure 2.1 4.0 7.5 0.6 1.2 0.3 2.0 -2.7 2.1 -1.3 -2.2 -2.6 1.5 -2.3 -2.5 -2.6
Pain type(s) experienced in last month: Hip pain 1.4 1.7 5.6 1.3 1.9 1.2 2.4 -1.0 1.4 -0.6 -1.3 -1.0 1.5 -0.8 -0.6 -0.9
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.9 -1.0 0.1 -0.0 0.4 1.3 -1.4 0.5 1.2 1.1 -1.3 1.1 1.2 1.2
High cholesterol (Self-reported) 1.1 1.9 4.2 1.3 0.9 1.0 1.7 -1.9 0.6 1.2 -0.3 -1.6 0.4 -1.5 -2.1 -2.0
Medication: Bendroflumethiazide 4.2 6.3 13.2 0.9 2.6 1.4 3.6 -3.0 2.2 1.5 -2.0 -2.9 2.1 -2.9 -3.0 -3.0
Medication: Paracetamol 0.9 1.3 3.2 -0.8 0.2 -0.6 -0.4 -1.4 0.1 -1.6 -0.6 -1.6 -0.5 -1.7 -1.8 -1.5
Medication: Lisinopril 0.8 1.1 2.3 0.7 1.4 0.4 1.2 -1.2 1.2 -0.6 -1.2 -1.2 1.5 -0.7 -0.7 -0.9
Medication: Atorvastatin 0.7 0.8 7.5 -2.7 -0.9 -0.2 -1.1 -0.2 -0.2 -0.4 -0.1 -0.4 -0.4 -0.2 -0.5 -0.4
Illnesses of father: High blood pressure 0.3 0.3 2.4 0.2 -0.1 -1.6 0.2 -0.0 -0.2 -1.0 0.2 0.2 -0.7 -0.2 -0.1 0.1
Alcohol drinker status: Never 0.9 1.0 3.4 -1.8 -0.1 -1.2 1.0 0.4 0.5 -1.6 -0.5 0.7 1.0 1.1 1.1 0.8
Ever smoked 0.8 1.4 3.5 1.9 0.2 1.4 -0.8 -0.8 -0.7 1.3 0.7 -0.9 -1.3 -1.6 -1.4 -1.3
Basal metabolic rate 0.7 3.9 15.9 1.4 -1.2 0.6 -1.2 1.1 -3.4 1.2 3.5 1.6 -4.0 -0.3 0.2 0.5
Leg fat percentage (left) 1.6 5.9 12.9 2.8 1.5 1.5 1.2 -3.1 1.8 0.1 -1.8 -2.9 1.1 -3.5 -3.6 -3.2
Arm fat-free mass (left) 0.6 3.0 13.5 1.3 -0.9 0.6 -1.2 0.8 -3.0 0.8 3.0 1.2 -3.7 -0.5 0.1 0.3
Number of operations (self-reported) 0.3 0.4 1.2 -0.2 0.6 0.5 0.2 0.6 -1.0 -0.5 1.1 0.9 -0.7 0.6 0.4 0.6
Average weekly beer plus cider intake 0.2 0.3 1.1 -0.3 -1.0 -1.1 1.0 0.3 0.2 -0.6 -0.4 0.2 -0.1 0.0 0.4 0.3
Irritability 0.3 0.4 3.0 -0.1 -0.6 -0.8 0.5 0.1 0.5 -1.7 -0.8 -0.2 0.3 -0.1 0.4 0.2
Risk taking 0.7 1.0 2.6 0.2 1.6 1.1 0.5 0.7 -1.2 1.4 1.3 0.7 -1.6 -0.4 -0.0 0.2
Ever had prostate specific antigen (PSA) test 2.3 2.6 9.8 -1.8 -3.1 -1.7 -2.4 0.9 0.1 -2.4 -0.3 0.8 0.9 1.3 1.1 1.3
Fractured/broken bones in last 5 years 0.7 0.9 2.1 0.5 -1.5 -0.7 -0.7 0.6 -1.4 0.5 1.4 0.8 -1.3 0.6 0.5 0.5
Age started oral contraceptive pill 0.8 1.0 4.3 2.1 0.5 0.8 1.0 -1.2 0.8 -0.2 -0.7 -1.0 1.0 -0.3 -0.8 -1.0
Diastolic blood pressure, automated reading 0.2 0.8 2.0 0.9 0.3 1.2 0.6 0.4 -1.3 1.1 1.3 0.5 -1.4 -0.3 -0.2 0.2
Ever depressed for a whole week 0.5 0.6 3.1 0.0 1.8 0.5 0.3 0.5 -0.9 -0.3 0.9 0.7 -1.0 0.5 0.7 0.6
Unable to work because of sickness or disability 0.2 0.3 0.9 -1.0 0.7 0.7 -0.3 -0.3 0.5 -0.7 -0.5 -0.5 0.3 -0.2 -0.4 -0.5
Commuting to job workplace: Cycle 2.5 3.0 6.2 -0.8 -0.4 -0.3 -1.2 2.1 -1.8 -1.4 1.7 2.2 -1.6 2.4 2.5 2.2
Myopia 0.7 1.0 3.1 0.5 0.5 0.6 0.0 1.2 -0.5 0.0 0.6 1.3 -0.2 1.8 1.6 1.4
Vascular/heart problems diagnosed by doctor 1.3 3.5 7.9 0.3 -1.1 0.3 -2.8 2.5 -1.8 0.4 1.6 2.1 -1.3 2.2 2.6 2.5
Cholesterol lowering medication 2.2 3.3 8.1 0.9 0.9 1.7 1.6 -2.4 1.2 0.7 -1.1 -2.3 0.6 -2.4 -2.8 -2.6
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.9 -1.0 -0.8 -0.6 0.6 1.0 -1.4 -0.7 1.1 1.0 -1.1 1.2 1.3 1.2
Pain experienced in last month 0.2 0.3 1.3 0.0 -0.3 0.4 -1.1 -0.5 0.7 0.8 -0.4 -0.3 0.9 0.0 -0.2 -0.4
Supplements: Calcium 0.6 0.6 2.0 -0.9 -1.0 -1.4 -1.3 0.2 -0.4 -0.9 0.2 0.3 -1.1 0.3 -0.1 0.3
Basal cell carcinoma (self-reported) 0.4 0.5 3.1 -1.8 0.8 -0.1 0.2 -0.6 0.4 0.9 -0.1 -0.4 0.9 -0.4 -0.6 -0.5
Heart attack/myocardial infarction (self-reported) 0.7 0.8 2.6 1.3 1.6 -0.1 0.8 -0.8 0.6 0.6 -0.6 -1.0 0.6 -1.0 -1.0 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 0.6 0.6 -0.4 -0.5 0.4 -0.9 1.1 1.1 0.7 -0.5 -0.1 0.1 0.2
Heart disease (siblings) 0.2 0.2 0.5 0.4 -0.1 -0.3 0.7 -0.7 0.2 -0.1 0.0 -0.3 0.5 -0.3 -0.6 -0.7
Alcohol drinker status: Previous 0.7 0.7 3.0 1.3 -0.1 0.7 -0.0 -0.1 -0.8 1.0 0.6 -0.2 -1.7 -1.2 -0.8 -0.6
Pack years of smoking 1.4 2.0 3.2 0.7 -1.4 -0.0 1.6 -1.6 1.7 -0.9 -1.7 -1.6 1.8 -1.5 -1.4 -1.4
Impedance of whole body 0.2 1.0 3.8 -0.9 0.2 -0.8 0.7 -0.6 1.6 -1.1 -1.7 -0.7 1.9 0.3 -0.0 -0.2
Leg fat mass (left) 0.7 2.7 7.9 2.8 0.5 1.5 0.5 -1.8 -0.0 0.5 0.1 -1.5 -0.7 -2.7 -2.6 -2.1
Arm predicted mass (left) 0.7 3.4 15.1 1.0 -1.2 0.3 -1.4 1.0 -3.2 0.7 3.2 1.4 -3.9 -0.3 0.2 0.5