Hub : Genes

CCBE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1980	0.0410	1.4e-07	0.034	0.084	0.098	0.090	0.090	4.7e-05	2.1e-10	5.9e-12	5.0e-11	4.3e-11
2	METSIM	Adipose	0.0672	0.0232	6.5e-04	-0.001	0.032	0.000	0.029	0.003	6.4e-01	1.2e-05	2.8e-01	2.6e-05	9.4e-02
3	TCGA	Breast Invasive Carcinoma	0.1386	0.0309	5.5e-12	0.078	0.066	0.070	NA	0.041	1.2e-15	1.9e-13	3.6e-14	NA	8.3e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	2.5	1.6	0.5	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.3	0.5	-0.6	0.5
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	0.6	0.1	-1.3
Depression (Nagel 2018)	0.7	1.0	2.2	-0.1	0.9	-1.5
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	0.1	-0.2	0.3
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.6	0.8	-1.3
Schizophrenia (2018)	0.3	0.6	1.3	-0.6	-1.2	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	0.6	-0.3	-0.5
Worry (Nagel 2018)	0.8	1.8	2.8	0.5	1.5	-1.7
Alzheimer’s Disease (in mother)	1.7	2.0	4.7	0.5	1.1	-2.2
Alzheimer’s Disease (in father)	0.1	0.2	0.3	-0.3	-0.3	0.5
Alzheimer’s Disease (including proxy)	1.3	1.9	3.7	0.9	1.1	-1.9
Crohns Disease (2017)	0.5	1.0	1.5	0.6	1.1	1.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.1	0.6	0.1
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.6	0.0	-0.9
Major Depression (MDD)	0.5	0.6	1.2	-0.1	1.1	-0.8
Reaction Time	0.2	0.4	1.0	1.0	-0.1	-0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.7	-1.1	-1.9	1.5
Breast Cancer	0.2	0.5	1.1	1.1	0.3	-0.6
Ovarian Cancer	0.6	0.8	2.2	0.4	1.5	0.2
Prostate Cancer	0.2	0.3	0.6	0.3	0.4	-0.8
Age at First Birth	1.5	2.2	3.9	-2.0	1.0	1.4
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.0	0.2	0.8
Body Mass Index (BMI) (2010)	2.4	3.3	8.8	0.4	-3.0	-0.9
Coronary Artery Disease (CAD)	0.4	0.5	0.7	0.6	-0.8	-0.7
Crohns Disease (2012)	0.8	1.3	3.3	1.8	0.8	0.4
Mean Putamen Volume	1.0	1.1	2.3	1.5	-0.1	-1.0
Fasting Glucose	0.4	0.5	1.0	-0.0	-1.0	-0.6
HbA1C	0.4	0.4	1.2	0.3	-0.1	-1.1
HDL Cholesterol	0.4	0.7	1.2	0.7	0.6	-1.1
LDL Cholesterol	1.2	1.9	3.8	-1.4	-0.1	1.9
Lupus	0.2	0.4	0.6	0.3	0.6	-0.8
Neuroticism (2016)	0.4	0.5	1.1	0.4	1.0	-0.5
Primary Biliary Cirrhosis	2.4	3.5	7.9	1.6	-0.0	-2.8
Rheumatoid Arthritis	0.8	1.0	2.4	-0.4	-0.8	1.5
Schizophrenia (2014)	0.2	0.4	0.6	-0.7	-0.5	0.7
Triglycerides	0.8	1.2	3.7	-0.0	0.1	1.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.6	-1.0	-1.9	-0.3
Ulcerative Colitis	0.5	0.7	2.2	-0.2	0.0	-1.5
Blood Eosinophil Count	0.1	0.7	1.1	0.9	1.1	0.3
Blood Platelet Count	0.1	1.0	1.3	-1.1	1.1	0.7
Blood Red Count	0.2	1.5	3.1	1.0	0.7	-1.8
Blood White Count	0.1	0.9	1.4	0.9	1.2	-0.7
Heel T-Score	0.5	4.2	8.3	1.7	-1.2	-2.9
BMI	0.5	3.0	7.2	-0.3	-2.7	-1.4
Height	0.3	6.4	15.5	-1.3	-3.9	-1.4
Waist Hip Ratio (WHR)	0.2	0.9	1.6	1.2	0.1	-1.0
Systolic Blood Pressure	0.1	0.6	1.2	-0.3	0.6	1.1
Smoking Status	1.2	2.9	5.5	-2.4	1.2	1.3
Allergy or Eczema	0.2	0.5	1.0	-0.5	-0.5	1.0
Cardiovascular Disease	0.1	0.3	0.6	-0.2	-0.8	0.4
Hypothyroidism (self reported)	0.9	2.0	3.3	-1.1	-1.3	1.8
Respiratory disease	0.7	1.5	3.1	-1.8	0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.4	-1.2	0.0
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.3	-0.8	0.9
Lung FVC	2.0	10.1	25.1	2.3	5.0	-0.2
Neuroticism	0.4	1.0	2.5	-0.5	1.6	-0.4
Chronotype (morning person)	0.3	0.6	1.1	-1.1	0.4	-0.8
Hair Pigment	0.0	0.8	2.4	-0.0	1.6	-0.3
Tanning	0.2	2.3	5.9	-0.9	-0.5	2.4
Hand grip strength (left)	1.7	4.5	7.5	-2.1	-1.3	2.7
Number of treatments/medications taken	0.7	1.2	2.6	-0.8	-1.6	0.5
Average weekly spirits intake	0.8	1.0	2.7	0.5	0.1	-1.6
Sensitivity / hurt feelings	0.2	0.4	0.8	0.3	0.5	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.5	0.3	-0.2	-1.6
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.2	0.2	0.2
Relative age of first facial hair	0.2	0.5	1.1	1.0	0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.4	0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.3	-0.2	-1.1	0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-0.4	-1.3	-0.0
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.3	-0.4	0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	-0.4	-0.1
Angina	0.1	0.1	0.1	0.4	-0.2	-0.0
Medication for hormone replacement therapy	1.6	1.8	4.4	-0.9	-2.1	0.5
Vitamin and mineral supplements	0.0	0.0	0.1	0.1	0.3	0.2
Supplements: Zinc	1.3	1.4	2.9	-1.1	-1.7	0.4
Medication: Co-codamol	0.2	0.2	0.4	-0.7	0.4	-0.2
Medication: Metformin	1.2	1.7	4.5	0.3	-2.1	-0.6
Diabetes (father)	0.7	0.8	1.5	-0.2	0.9	1.2
Diabetes (mother)	3.5	4.4	10.8	1.6	0.1	-3.3
Severe depression (siblings)	0.7	0.8	2.3	-0.1	0.0	1.5
Pack years adult smoking proportion	0.0	0.1	0.1	-0.3	-0.3	-0.0
Impedance of leg (right)	3.4	16.5	42.0	2.3	6.5	1.5
Leg fat-free mass (left)	2.2	11.9	29.4	-1.4	-5.4	-2.0
Trunk fat percentage	0.3	1.1	1.8	0.3	1.2	-1.3
Hand grip strength (right)	0.9	2.5	4.7	-1.4	-1.0	2.2
Townsend deprivation index at recruitment	0.7	1.0	1.9	1.4	0.8	-0.7
Current tobacco smoking	0.4	0.7	1.3	-0.9	-0.2	1.1
Average weekly fortified wine intake	2.4	2.8	8.1	-0.0	-2.8	0.5
Maternal smoking around birth	0.6	0.8	2.4	-1.5	-0.2	0.3
Fed-up feelings	0.3	0.5	0.5	0.7	0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.7	-0.1	-0.8
Relative age voice broke	0.9	1.4	3.5	0.0	0.9	1.9
Taking other prescription medications	2.6	4.0	6.5	-2.6	-1.7	1.5
Age when periods started (menarche)	0.3	0.7	1.8	-0.1	-0.3	-1.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.0	1.7	-0.1	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.0	1.0	-0.9	0.4
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.5	1.6	0.0	-1.9
Qualifications: CSEs or equivalent	1.0	1.3	3.0	0.8	1.7	-0.3
Serious illness, injury or assault to yourself	1.4	1.7	3.0	-1.7	-1.4	-0.5
High blood pressure	0.1	0.3	0.8	-0.1	-0.9	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.2	0.5	-0.4	0.3
Multivitamins +/- minerals	0.1	0.1	0.2	0.1	0.5	0.1
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.6	0.3	-0.1
Supplements: Glucosamine	0.1	0.2	0.5	-0.7	-0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	0.6	0.4	-1.1
Medication: Atenolol	1.5	1.9	5.3	0.5	-2.3	-0.3
Medication: Levothyroxine sodium	2.5	4.3	7.1	-2.1	-2.7	1.1
Sitting height	0.3	2.1	3.2	-0.9	-1.5	-1.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	1.0	-0.2	0.1
High blood pressure (mother)	0.1	0.1	0.2	-0.3	-0.5	0.0
Body mass index (BMI)	0.3	1.2	1.9	-0.3	-1.4	-1.3
Impedance of leg (left)	3.5	17.1	43.5	2.2	6.6	1.8
Leg predicted mass (left)	2.2	11.7	29.1	-1.4	-5.4	-2.0
Trunk fat mass	0.2	0.8	2.2	-0.2	-0.4	-1.5
Waist circumference	0.8	3.0	6.5	0.7	-1.4	-2.6
Number of incorrect matches in round	0.9	1.4	3.7	-1.9	-0.8	-0.2
Past tobacco smoking	0.7	1.2	3.0	1.7	-0.8	-0.2
Alcohol usually taken with meals	1.0	1.6	2.9	1.2	0.6	-1.7
Nervous feelings	1.0	1.9	2.8	1.5	0.8	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	-0.5	0.1	-0.9
Hearing difficulty/problems with background noise	0.8	1.2	2.5	0.9	-0.7	-1.6
Hair/balding pattern: Pattern 2	2.7	3.4	6.3	-2.5	-1.4	1.4
Had menopause	0.2	0.3	0.7	-0.8	0.3	-0.1
Had other major operations	0.3	0.4	1.0	0.5	-0.1	-1.0
Forced vital capacity (FVC)	0.7	2.8	5.8	1.6	2.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	-0.0	-0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.5	-0.5	0.8	-1.2
Qualifications: None of the above	0.2	0.4	0.6	0.8	0.7	-0.2
Financial difficulties in last 2 years	0.1	0.1	0.3	0.2	-0.5	-0.3
Mouth/teeth dental problems	0.2	0.4	0.6	0.8	0.0	-0.7
Heart attack	0.9	1.2	3.4	-0.0	-1.8	0.2
Allergy	0.0	0.1	0.2	0.0	0.4	0.3
Pain all over the body in last month	1.0	1.0	2.8	-0.5	-1.7	-0.2
Diabetes (self-reported)	0.7	1.1	2.6	0.4	-1.6	-0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	-1.2	-1.1	0.3
Medication: Ramipril	2.0	2.5	3.9	1.8	-0.7	-2.0
Medication: Simvastatin	0.4	0.6	1.4	0.4	-0.4	1.2
Fluid intelligence score	1.3	2.7	6.9	-0.8	-0.6	2.6
Illnesses of siblings	0.2	0.3	0.5	0.6	0.3	0.7
Neuroticism score	0.7	1.6	2.1	1.1	1.2	-1.5
Weight	0.8	3.9	7.0	-0.7	-2.6	-2.0
Impedance of arm (right)	1.4	6.6	13.9	2.2	3.7	-1.0
Arm fat percentage (right)	0.5	2.0	5.4	0.7	0.2	-2.3
Trunk fat-free mass	2.0	11.5	30.8	-1.4	-5.5	-1.4
Hip circumference	0.3	1.1	2.4	-0.2	-0.9	-1.5
Time employed in main current job	0.7	0.9	2.1	-0.2	1.4	0.6
Alcohol intake versus 10 years previously	1.2	1.9	4.2	2.0	1.1	-0.3
Father’s age at death	2.3	3.0	5.3	0.4	1.9	-2.3
Worrier / anxious feelings	2.5	4.7	7.8	1.4	2.8	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.8	0.6	0.9
Falls in the last year	0.1	0.1	0.3	0.0	0.1	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.4	-1.0	-0.4
Number of live births	0.7	1.0	2.0	-0.7	-0.7	-1.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.4	1.3	2.3	0.4
Pulse rate	1.0	1.7	3.0	1.3	-0.6	-1.7
Happiness	1.1	1.3	2.8	0.8	-1.7	-0.7
Noisy workplace	0.4	0.5	1.1	-0.1	-0.7	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.8	-1.0	0.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.3	-0.2	1.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.4	-0.4	0.2
Asthma	0.3	0.6	1.7	-1.3	-0.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.0	1.4	-0.2	-1.0
Medication: Cholesterol lowering	0.5	0.8	1.3	-1.0	-0.4	1.1
Depression (self-reported)	0.3	0.3	0.9	-0.3	0.3	-0.9
Medication: Lansoprazole	0.3	0.4	0.7	0.7	-0.3	-0.8
Prospective memory result	2.3	2.8	6.5	1.4	-0.1	-2.5
Lung cancer (father)	0.0	0.0	0.1	0.0	-0.3	-0.1
Illnesses of mother	1.2	1.5	4.3	-0.3	-0.0	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.6	1.5	1.6	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.5	-0.1	-0.6
Impedance of arm (left)	1.4	6.6	17.2	1.5	4.1	-0.6
Arm fat mass (right)	0.5	1.9	4.1	-0.0	-1.3	-2.0
Trunk predicted mass	2.0	11.2	29.6	-1.3	-5.4	-1.5
Standing height	0.6	5.7	12.5	-1.5	-3.5	-1.5
Length of working week for main job	0.2	0.2	0.3	-0.4	0.5	-0.5
Exposure to tobacco smoke at home	1.0	1.1	2.2	0.7	1.5	-0.8
Breastfed as a baby	0.4	0.5	1.1	-1.0	-0.1	0.7
Tense / ‘highly strung’	0.5	0.9	1.3	0.4	1.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.9	-2.2	-0.2	0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	1.0	0.5	-0.5
Birth weight of first child	0.3	0.5	1.1	0.7	1.0	-0.0
Peak expiratory flow (PEF)	2.2	5.2	8.6	-2.2	1.4	2.9
Pulse wave reflection index	0.5	0.7	1.6	-0.7	-0.0	1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	0.4	-0.7	0.6
Loud music exposure frequency	1.4	1.5	3.1	1.0	0.8	-1.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	0.1	-1.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.1	-0.5	-0.3
Blood clot in the leg (DVT)	1.1	1.5	2.5	1.6	0.1	-1.4
Medication: Paracetamol	0.9	1.5	3.4	1.8	0.3	-1.0
Headache pain in last month	0.6	1.1	1.3	1.1	1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.5	0.2	-0.0
Glaucoma (self-reported)	0.1	0.1	0.4	-0.6	-0.1	0.2
Gout (self-reported)	0.3	0.3	0.5	-0.7	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.3	-0.9	-1.5	0.9
Medication: Amlodipine	0.3	0.5	1.3	0.3	-0.3	-1.1
Medication: Ventolin 100micrograms inhaler	1.8	2.4	2.9	-1.7	-1.1	1.7
Birth weight	0.0	0.1	0.3	-0.2	0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.8	0.3	-0.1
High blood pressure (siblings)	0.8	1.1	2.5	-0.1	-1.6	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	2.3	1.0	1.5	0.0
Body fat percentage	0.4	1.6	2.5	0.5	1.6	-1.5
Leg fat percentage (right)	0.7	2.4	6.4	0.7	2.5	-0.6
Arm fat-free mass (right)	1.7	8.7	22.5	-1.5	-4.7	-1.1
Exposure to tobacco smoke outside home	0.4	0.5	1.3	0.4	1.1	-0.3
Comparative body size at age 10	2.4	6.5	17.0	1.1	-4.1	-1.2
Number of full brothers	0.4	0.5	1.1	-0.5	1.0	0.2
Worry too long after embarrassment	1.2	1.9	3.2	1.8	0.8	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.2	-1.8	-1.0	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	-1.2	-0.3	-0.2
Number of children fathered	3.2	3.6	8.5	-2.9	0.6	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-0.3	1.4	-0.3
Age at first live birth	0.2	0.3	0.7	-0.0	-0.4	0.8
Pulse wave peak to peak time	0.1	0.1	0.2	-0.3	-0.0	0.5
Health satisfaction	2.5	3.2	5.2	2.0	0.5	-2.3
Shortness of breath walking on level ground	0.0	0.0	0.1	0.1	0.3	-0.1
Qualifications: College or University degree	0.6	1.8	2.5	-1.4	-1.0	1.6
Eye problems/disorders: None of the above	0.7	0.8	1.1	-0.9	-0.6	1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.0	1.0	1.7	-0.3
Emphysema/chronic bronchitis	0.5	0.5	1.1	1.1	0.7	0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	-0.6	0.5	0.5
Neck or shoulder pain in last month	0.6	0.9	1.5	1.0	0.1	-1.2
Medication: Blood pressure	0.1	0.3	0.4	0.3	-0.6	-0.5
Angina (self-reported)	0.1	0.1	0.2	0.4	-0.3	0.1
Migraine (self-reported)	0.8	1.0	2.4	0.6	1.5	-0.6
Medication: Ibuprofen	0.1	0.1	0.4	0.6	0.1	0.1
Medication: Allopurinol	0.5	0.7	1.6	-0.4	-1.3	-0.3
Medication: Omeprazole	0.9	1.0	1.7	-1.2	0.4	1.3
Medication: Seretide 50 evohaler	0.7	0.8	1.3	-0.7	-0.7	1.1
Mean time to correctly identify matches	0.1	0.2	0.5	-0.1	-0.7	-0.3
Heart disease (mother)	0.4	0.5	1.1	-0.4	1.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.9	-0.7	-1.4	0.7
Whole body fat mass	0.2	0.9	2.6	0.0	-0.3	-1.6
Leg fat mass (right)	0.2	0.8	2.2	0.3	-0.3	-1.5
Arm predicted mass (right)	1.6	8.4	21.6	-1.3	-4.7	-1.4
Pulse rate, automated reading	0.4	1.3	1.9	1.4	0.2	-1.4
Alcohol intake frequency.	0.3	0.7	1.4	1.2	-0.1	-0.8
Comparative height size at age 10	0.8	4.4	9.0	-0.5	-3.0	-2.0
Number of full sisters	0.1	0.2	0.3	0.5	-0.3	-0.4
Suffer from ‘nerves’	1.7	2.7	3.3	1.6	1.5	-1.8
Overall health rating	0.5	1.1	1.6	1.3	-1.0	-0.9
Chest pain or discomfort	0.3	0.5	1.3	-1.1	-0.4	0.0
Had major operations	1.0	1.1	3.1	0.3	-1.8	-0.5
Age at last live birth	0.1	0.2	0.4	0.3	0.7	-0.1
Family relationship satisfaction	0.8	1.0	2.5	1.6	-0.6	-0.3
Leg pain on walking	2.3	2.9	5.2	1.8	0.3	-2.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.2	-0.2	0.4	0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.9	0.0	0.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	1.2	-0.1	-1.1
Medication: Aspirin	0.5	0.7	1.4	-0.6	-1.2	0.6
Supplements: Vitamin C	1.8	2.1	4.0	-1.4	-2.0	0.5
Knee pain experienced in last month	0.8	1.2	2.3	1.0	-0.5	-1.5
Hypertension (Self-reported)	0.1	0.3	0.9	-0.2	-0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.4	1.1	-0.3
Illnesses of father: Heart disease	0.7	1.0	2.1	-1.4	-0.6	0.7
Illnesses of siblings: Diabetes	0.5	0.7	0.7	-0.8	0.8	0.8
Smoking status: Previous	1.2	1.8	3.6	-1.9	1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	1.1	-0.9	-0.5
Whole body fat-free mass	2.2	12.3	32.1	-1.5	-5.7	-1.6
Leg fat-free mass (right)	2.4	12.8	31.7	-1.7	-5.6	-1.9
Arm fat percentage (left)	0.4	1.7	4.9	0.4	0.3	-2.2
Average weekly red wine intake	0.4	0.5	1.0	-0.2	-0.7	-1.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.1	0.7	2.0	0.1
Mood swings	0.6	1.1	1.8	1.3	-0.6	-1.1
Loneliness, isolation	0.7	1.0	2.2	0.2	1.5	-0.9
Long-standing illness, disability or infirmity	0.5	0.7	1.9	0.1	-1.4	-0.4
Ever had bowel cancer screening	0.2	0.2	0.3	0.5	-0.3	-0.6
Diabetes diagnosed by doctor	0.9	1.5	3.0	0.2	-1.7	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.5	0.4	0.2
Friendships satisfaction	0.8	1.0	2.2	1.5	-0.8	0.1
Qualifications: nursing, teaching	0.4	0.6	1.3	0.6	-1.2	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.1	0.7	-0.4
Eye problems/disorders: Cataract	1.8	2.1	3.8	1.6	0.3	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.2	-0.4	1.8	0.7
Medication for cholesterol	0.4	0.6	1.7	-0.3	1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	0.6	-0.3	-0.2
Back pain experienced in last month	0.8	1.1	2.0	1.4	1.1	-0.3
Mineral and other dietary supplements	0.7	0.9	2.5	-0.4	-0.3	1.6
Breast cancer (self-reported)	2.4	2.8	5.4	-2.3	-0.4	1.7
Asthma (self-reported)	0.3	0.7	1.9	-1.4	-0.2	0.3
Osteoporosis (self-reported)	0.6	0.7	1.8	0.4	-1.3	0.4
Osteoarthritis (self-reported)	0.9	1.2	1.7	-1.3	-1.2	0.6
Medication: Aspirin	0.8	1.0	1.4	-0.8	-1.0	1.2
Medication: Gliclazide	1.0	1.1	2.1	-1.1	0.2	1.4
Illnesses of father: None of the above (group 1)	1.1	1.4	2.0	1.0	1.4	-1.0
Smoking status: Current	0.4	0.6	1.2	-0.6	-0.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	8.9	1.0	3.0	0.2
Whole body water mass	2.2	12.7	33.1	-1.5	-5.8	-1.7
Leg predicted mass (right)	2.5	13.3	33.3	-1.7	-5.8	-1.9
Arm fat mass (left)	0.5	2.2	4.1	-0.1	-1.5	-2.0
Number of self-reported non-cancer illnesses	0.7	1.2	3.3	-0.7	-1.8	0.1
Average weekly champagne plus white wine intake	0.5	0.7	1.1	1.1	0.7	-0.8
Miserableness	0.8	1.5	2.8	1.2	0.4	-1.7
Guilty feelings	1.6	2.5	3.3	-1.8	-1.5	1.4
Wears glasses or contact lenses	0.3	0.4	0.8	-0.9	-0.2	0.6
Ever taken oral contraceptive pill	1.5	1.7	4.1	-2.0	-0.7	0.6
Hearing aid user	0.9	1.0	2.8	-1.7	-0.1	0.5
Mother’s age at death	0.2	0.2	0.2	-0.5	-0.4	-0.5
Financial situation satisfaction	0.5	0.6	0.8	0.7	-0.7	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	1.1	0.1	-0.3
Commuting to job workplace: Public transport	0.6	0.7	1.0	-1.0	-0.7	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.3	0.7	0.2
Medication: Blood pressure	0.3	0.6	1.2	0.7	-0.2	-1.1
Pain type(s) experienced in last month: Hip pain	2.1	2.7	3.6	1.9	1.8	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	0.3	-0.0	-1.0
High cholesterol (Self-reported)	2.0	3.6	7.8	-1.7	-0.3	2.8
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.1	0.2	0.1
Medication: Paracetamol	0.6	0.9	2.2	1.5	0.5	-0.4
Medication: Lisinopril	0.7	0.9	1.8	-0.5	1.4	0.8
Medication: Atorvastatin	0.6	0.8	1.2	-1.1	-0.2	1.0
Illnesses of father: High blood pressure	1.4	1.7	2.7	-1.6	0.4	1.5
Alcohol drinker status: Never	0.2	0.2	0.4	0.5	0.0	0.6
Ever smoked	0.4	0.7	2.0	-1.4	0.2	0.3
Basal metabolic rate	1.8	9.8	25.3	-1.2	-5.0	-1.6
Leg fat percentage (left)	0.6	2.3	6.6	0.5	2.6	-0.3
Arm fat-free mass (left)	1.5	7.7	20.4	-0.9	-4.5	-1.4
Number of operations (self-reported)	0.8	1.2	2.2	0.2	-1.5	-1.1
Average weekly beer plus cider intake	0.7	1.1	2.2	1.0	1.5	0.1
Irritability	0.1	0.1	0.3	0.5	0.0	-0.1
Risk taking	0.8	1.1	1.9	-1.4	0.4	1.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.2	-1.0	-1.1	0.7
Fractured/broken bones in last 5 years	0.8	1.1	2.1	-1.4	-0.3	1.0
Age started oral contraceptive pill	0.4	0.5	1.3	0.0	-1.1	-0.4
Diastolic blood pressure, automated reading	0.2	0.5	0.7	-0.7	-0.9	-0.5
Ever depressed for a whole week	0.8	1.0	1.5	-1.2	1.0	-0.5
Unable to work because of sickness or disability	0.6	0.7	1.4	-0.9	-0.2	1.2
Commuting to job workplace: Cycle	0.6	0.8	1.4	-1.2	-0.9	-0.1
Myopia	0.8	1.1	3.2	1.8	0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.4	-0.2	1.5	0.0
Cholesterol lowering medication	0.1	0.2	0.4	0.6	0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.7	-1.6	-0.9	1.1
Pain experienced in last month	1.1	1.9	4.5	-2.1	-0.0	1.0
Supplements: Calcium	1.9	2.1	4.0	-1.1	1.0	2.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-1.1	-0.0	-0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.1	0.1	-1.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	1.4	0.0	-1.5
Heart disease (siblings)	0.3	0.4	1.1	0.1	1.0	-0.4
Alcohol drinker status: Previous	0.6	0.6	1.3	0.4	-0.7	-1.1
Pack years of smoking	0.1	0.1	0.2	-0.5	-0.1	0.0
Impedance of whole body	2.6	13.0	34.6	2.0	5.9	0.7
Leg fat mass (left)	0.2	0.7	2.0	0.2	-0.3	-1.4
Arm predicted mass (left)	1.4	7.1	18.9	-0.7	-4.3	-1.4