Hub : Genes

CCBE1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1980 0.0410 1.4e-07 0.034 0.084 0.098 0.090 0.090 4.7e-05 2.1e-10 5.9e-12 5.0e-11 4.3e-11
2 METSIM Adipose 0.0672 0.0232 6.5e-04 -0.001 0.032 0.000 0.029 0.003 6.4e-01 1.2e-05 2.8e-01 2.6e-05 9.4e-02
3 TCGA Breast Invasive Carcinoma 0.1386 0.0309 5.5e-12 0.078 0.066 0.070 NA 0.041 1.2e-15 1.9e-13 3.6e-14 NA 8.3e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 2.5 1.6 0.5 0.7
Bipolar Disorder or Schizophrenia 0.1 0.3 0.3 0.5 -0.6 0.5
Depressed Affect (Nagel 2018) 0.3 0.7 1.7 0.6 0.1 -1.3
Depression (Nagel 2018) 0.7 1.0 2.2 -0.1 0.9 -1.5
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.1 0.1 -0.2 0.3
Neuroticism (Nagel 2018) 0.4 0.9 1.8 0.6 0.8 -1.3
Schizophrenia (2018) 0.3 0.6 1.3 -0.6 -1.2 0.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.4 0.6 -0.3 -0.5
Worry (Nagel 2018) 0.8 1.8 2.8 0.5 1.5 -1.7
Alzheimer’s Disease (in mother) 1.7 2.0 4.7 0.5 1.1 -2.2
Alzheimer’s Disease (in father) 0.1 0.2 0.3 -0.3 -0.3 0.5
Alzheimer’s Disease (including proxy) 1.3 1.9 3.7 0.9 1.1 -1.9
Crohns Disease (2017) 0.5 1.0 1.5 0.6 1.1 1.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.1 0.6 0.1
Ulcerative Colitis (UC) 0.2 0.4 0.8 -0.6 0.0 -0.9
Major Depression (MDD) 0.5 0.6 1.2 -0.1 1.1 -0.8
Reaction Time 0.2 0.4 1.0 1.0 -0.1 -0.6
Verbal and Numeric Reasoning (VNR) 1.0 2.4 3.7 -1.1 -1.9 1.5
Breast Cancer 0.2 0.5 1.1 1.1 0.3 -0.6
Ovarian Cancer 0.6 0.8 2.2 0.4 1.5 0.2
Prostate Cancer 0.2 0.3 0.6 0.3 0.4 -0.8
Age at First Birth 1.5 2.2 3.9 -2.0 1.0 1.4
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.0 0.2 0.8
Body Mass Index (BMI) (2010) 2.4 3.3 8.8 0.4 -3.0 -0.9
Coronary Artery Disease (CAD) 0.4 0.5 0.7 0.6 -0.8 -0.7
Crohns Disease (2012) 0.8 1.3 3.3 1.8 0.8 0.4
Mean Putamen Volume 1.0 1.1 2.3 1.5 -0.1 -1.0
Fasting Glucose 0.4 0.5 1.0 -0.0 -1.0 -0.6
HbA1C 0.4 0.4 1.2 0.3 -0.1 -1.1
HDL Cholesterol 0.4 0.7 1.2 0.7 0.6 -1.1
LDL Cholesterol 1.2 1.9 3.8 -1.4 -0.1 1.9
Lupus 0.2 0.4 0.6 0.3 0.6 -0.8
Neuroticism (2016) 0.4 0.5 1.1 0.4 1.0 -0.5
Primary Biliary Cirrhosis 2.4 3.5 7.9 1.6 -0.0 -2.8
Rheumatoid Arthritis 0.8 1.0 2.4 -0.4 -0.8 1.5
Schizophrenia (2014) 0.2 0.4 0.6 -0.7 -0.5 0.7
Triglycerides 0.8 1.2 3.7 -0.0 0.1 1.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.6 -1.0 -1.9 -0.3
Ulcerative Colitis 0.5 0.7 2.2 -0.2 0.0 -1.5
Blood Eosinophil Count 0.1 0.7 1.1 0.9 1.1 0.3
Blood Platelet Count 0.1 1.0 1.3 -1.1 1.1 0.7
Blood Red Count 0.2 1.5 3.1 1.0 0.7 -1.8
Blood White Count 0.1 0.9 1.4 0.9 1.2 -0.7
Heel T-Score 0.5 4.2 8.3 1.7 -1.2 -2.9
BMI 0.5 3.0 7.2 -0.3 -2.7 -1.4
Height 0.3 6.4 15.5 -1.3 -3.9 -1.4
Waist Hip Ratio (WHR) 0.2 0.9 1.6 1.2 0.1 -1.0
Systolic Blood Pressure 0.1 0.6 1.2 -0.3 0.6 1.1
Smoking Status 1.2 2.9 5.5 -2.4 1.2 1.3
Allergy or Eczema 0.2 0.5 1.0 -0.5 -0.5 1.0
Cardiovascular Disease 0.1 0.3 0.6 -0.2 -0.8 0.4
Hypothyroidism (self reported) 0.9 2.0 3.3 -1.1 -1.3 1.8
Respiratory disease 0.7 1.5 3.1 -1.8 0.4 1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.6 0.4 -1.2 0.0
Lung FEV1/FVC ratio 0.1 0.5 0.9 -0.3 -0.8 0.9
Lung FVC 2.0 10.1 25.1 2.3 5.0 -0.2
Neuroticism 0.4 1.0 2.5 -0.5 1.6 -0.4
Chronotype (morning person) 0.3 0.6 1.1 -1.1 0.4 -0.8
Hair Pigment 0.0 0.8 2.4 -0.0 1.6 -0.3
Tanning 0.2 2.3 5.9 -0.9 -0.5 2.4
Hand grip strength (left) 1.7 4.5 7.5 -2.1 -1.3 2.7
Number of treatments/medications taken 0.7 1.2 2.6 -0.8 -1.6 0.5
Average weekly spirits intake 0.8 1.0 2.7 0.5 0.1 -1.6
Sensitivity / hurt feelings 0.2 0.4 0.8 0.3 0.5 -0.9
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.5 0.3 -0.2 -1.6
Hearing difficulty/problems: Yes 0.0 0.0 0.1 -0.2 0.2 0.2
Relative age of first facial hair 0.2 0.5 1.1 1.0 0.5 0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.4 0.2 -0.4
Ever used hormone-replacement therapy (HRT) 0.4 0.4 1.3 -0.2 -1.1 0.1
Ever had hysterectomy (womb removed) 0.5 0.6 1.6 -0.4 -1.3 -0.0
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.3 -0.4 0.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.4 -0.4 -0.1
Angina 0.1 0.1 0.1 0.4 -0.2 -0.0
Medication for hormone replacement therapy 1.6 1.8 4.4 -0.9 -2.1 0.5
Vitamin and mineral supplements 0.0 0.0 0.1 0.1 0.3 0.2
Supplements: Zinc 1.3 1.4 2.9 -1.1 -1.7 0.4
Medication: Co-codamol 0.2 0.2 0.4 -0.7 0.4 -0.2
Medication: Metformin 1.2 1.7 4.5 0.3 -2.1 -0.6
Diabetes (father) 0.7 0.8 1.5 -0.2 0.9 1.2
Diabetes (mother) 3.5 4.4 10.8 1.6 0.1 -3.3
Severe depression (siblings) 0.7 0.8 2.3 -0.1 0.0 1.5
Pack years adult smoking proportion 0.0 0.1 0.1 -0.3 -0.3 -0.0
Impedance of leg (right) 3.4 16.5 42.0 2.3 6.5 1.5
Leg fat-free mass (left) 2.2 11.9 29.4 -1.4 -5.4 -2.0
Trunk fat percentage 0.3 1.1 1.8 0.3 1.2 -1.3
Hand grip strength (right) 0.9 2.5 4.7 -1.4 -1.0 2.2
Townsend deprivation index at recruitment 0.7 1.0 1.9 1.4 0.8 -0.7
Current tobacco smoking 0.4 0.7 1.3 -0.9 -0.2 1.1
Average weekly fortified wine intake 2.4 2.8 8.1 -0.0 -2.8 0.5
Maternal smoking around birth 0.6 0.8 2.4 -1.5 -0.2 0.3
Fed-up feelings 0.3 0.5 0.5 0.7 0.7 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 -0.7 -0.1 -0.8
Relative age voice broke 0.9 1.4 3.5 0.0 0.9 1.9
Taking other prescription medications 2.6 4.0 6.5 -2.6 -1.7 1.5
Age when periods started (menarche) 0.3 0.7 1.8 -0.1 -0.3 -1.4
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.0 1.7 -0.1 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.0 1.0 -0.9 0.4
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.5 1.6 0.0 -1.9
Qualifications: CSEs or equivalent 1.0 1.3 3.0 0.8 1.7 -0.3
Serious illness, injury or assault to yourself 1.4 1.7 3.0 -1.7 -1.4 -0.5
High blood pressure 0.1 0.3 0.8 -0.1 -0.9 -0.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.2 0.5 -0.4 0.3
Multivitamins +/- minerals 0.1 0.1 0.2 0.1 0.5 0.1
Stomach or abdominal pain in last month 0.1 0.1 0.4 -0.6 0.3 -0.1
Supplements: Glucosamine 0.1 0.2 0.5 -0.7 -0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 0.6 0.4 -1.1
Medication: Atenolol 1.5 1.9 5.3 0.5 -2.3 -0.3
Medication: Levothyroxine sodium 2.5 4.3 7.1 -2.1 -2.7 1.1
Sitting height 0.3 2.1 3.2 -0.9 -1.5 -1.8
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 1.0 -0.2 0.1
High blood pressure (mother) 0.1 0.1 0.2 -0.3 -0.5 0.0
Body mass index (BMI) 0.3 1.2 1.9 -0.3 -1.4 -1.3
Impedance of leg (left) 3.5 17.1 43.5 2.2 6.6 1.8
Leg predicted mass (left) 2.2 11.7 29.1 -1.4 -5.4 -2.0
Trunk fat mass 0.2 0.8 2.2 -0.2 -0.4 -1.5
Waist circumference 0.8 3.0 6.5 0.7 -1.4 -2.6
Number of incorrect matches in round 0.9 1.4 3.7 -1.9 -0.8 -0.2
Past tobacco smoking 0.7 1.2 3.0 1.7 -0.8 -0.2
Alcohol usually taken with meals 1.0 1.6 2.9 1.2 0.6 -1.7
Nervous feelings 1.0 1.9 2.8 1.5 0.8 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.9 -0.5 0.1 -0.9
Hearing difficulty/problems with background noise 0.8 1.2 2.5 0.9 -0.7 -1.6
Hair/balding pattern: Pattern 2 2.7 3.4 6.3 -2.5 -1.4 1.4
Had menopause 0.2 0.3 0.7 -0.8 0.3 -0.1
Had other major operations 0.3 0.4 1.0 0.5 -0.1 -1.0
Forced vital capacity (FVC) 0.7 2.8 5.8 1.6 2.4 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.3 -0.0 -0.5 0.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.5 -0.5 0.8 -1.2
Qualifications: None of the above 0.2 0.4 0.6 0.8 0.7 -0.2
Financial difficulties in last 2 years 0.1 0.1 0.3 0.2 -0.5 -0.3
Mouth/teeth dental problems 0.2 0.4 0.6 0.8 0.0 -0.7
Heart attack 0.9 1.2 3.4 -0.0 -1.8 0.2
Allergy 0.0 0.1 0.2 0.0 0.4 0.3
Pain all over the body in last month 1.0 1.0 2.8 -0.5 -1.7 -0.2
Diabetes (self-reported) 0.7 1.1 2.6 0.4 -1.6 -0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.4 -1.2 -1.1 0.3
Medication: Ramipril 2.0 2.5 3.9 1.8 -0.7 -2.0
Medication: Simvastatin 0.4 0.6 1.4 0.4 -0.4 1.2
Fluid intelligence score 1.3 2.7 6.9 -0.8 -0.6 2.6
Illnesses of siblings 0.2 0.3 0.5 0.6 0.3 0.7
Neuroticism score 0.7 1.6 2.1 1.1 1.2 -1.5
Weight 0.8 3.9 7.0 -0.7 -2.6 -2.0
Impedance of arm (right) 1.4 6.6 13.9 2.2 3.7 -1.0
Arm fat percentage (right) 0.5 2.0 5.4 0.7 0.2 -2.3
Trunk fat-free mass 2.0 11.5 30.8 -1.4 -5.5 -1.4
Hip circumference 0.3 1.1 2.4 -0.2 -0.9 -1.5
Time employed in main current job 0.7 0.9 2.1 -0.2 1.4 0.6
Alcohol intake versus 10 years previously 1.2 1.9 4.2 2.0 1.1 -0.3
Father’s age at death 2.3 3.0 5.3 0.4 1.9 -2.3
Worrier / anxious feelings 2.5 4.7 7.8 1.4 2.8 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 -0.8 0.6 0.9
Falls in the last year 0.1 0.1 0.3 0.0 0.1 -0.5
Hair/balding pattern: Pattern 3 0.3 0.4 1.0 0.4 -1.0 -0.4
Number of live births 0.7 1.0 2.0 -0.7 -0.7 -1.4
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 5.4 1.3 2.3 0.4
Pulse rate 1.0 1.7 3.0 1.3 -0.6 -1.7
Happiness 1.1 1.3 2.8 0.8 -1.7 -0.7
Noisy workplace 0.4 0.5 1.1 -0.1 -0.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.8 -1.0 0.3 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 -0.3 -0.2 1.0
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.4 -0.4 0.2
Asthma 0.3 0.6 1.7 -1.3 -0.3 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.0 1.4 -0.2 -1.0
Medication: Cholesterol lowering 0.5 0.8 1.3 -1.0 -0.4 1.1
Depression (self-reported) 0.3 0.3 0.9 -0.3 0.3 -0.9
Medication: Lansoprazole 0.3 0.4 0.7 0.7 -0.3 -0.8
Prospective memory result 2.3 2.8 6.5 1.4 -0.1 -2.5
Lung cancer (father) 0.0 0.0 0.1 0.0 -0.3 -0.1
Illnesses of mother 1.2 1.5 4.3 -0.3 -0.0 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 2.6 1.5 1.6 0.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.5 -0.1 -0.6
Impedance of arm (left) 1.4 6.6 17.2 1.5 4.1 -0.6
Arm fat mass (right) 0.5 1.9 4.1 -0.0 -1.3 -2.0
Trunk predicted mass 2.0 11.2 29.6 -1.3 -5.4 -1.5
Standing height 0.6 5.7 12.5 -1.5 -3.5 -1.5
Length of working week for main job 0.2 0.2 0.3 -0.4 0.5 -0.5
Exposure to tobacco smoke at home 1.0 1.1 2.2 0.7 1.5 -0.8
Breastfed as a baby 0.4 0.5 1.1 -1.0 -0.1 0.7
Tense / ‘highly strung’ 0.5 0.9 1.3 0.4 1.2 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.9 -2.2 -0.2 0.7
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 1.0 0.5 -0.5
Birth weight of first child 0.3 0.5 1.1 0.7 1.0 -0.0
Peak expiratory flow (PEF) 2.2 5.2 8.6 -2.2 1.4 2.9
Pulse wave reflection index 0.5 0.7 1.6 -0.7 -0.0 1.2
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.5 0.4 -0.7 0.6
Loud music exposure frequency 1.4 1.5 3.1 1.0 0.8 -1.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.4 0.1 -1.2 0.4
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.1 -0.5 -0.3
Blood clot in the leg (DVT) 1.1 1.5 2.5 1.6 0.1 -1.4
Medication: Paracetamol 0.9 1.5 3.4 1.8 0.3 -1.0
Headache pain in last month 0.6 1.1 1.3 1.1 1.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 0.5 0.2 -0.0
Glaucoma (self-reported) 0.1 0.1 0.4 -0.6 -0.1 0.2
Gout (self-reported) 0.3 0.3 0.5 -0.7 -0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.3 -0.9 -1.5 0.9
Medication: Amlodipine 0.3 0.5 1.3 0.3 -0.3 -1.1
Medication: Ventolin 100micrograms inhaler 1.8 2.4 2.9 -1.7 -1.1 1.7
Birth weight 0.0 0.1 0.3 -0.2 0.1 -0.5
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 -0.8 0.3 -0.1
High blood pressure (siblings) 0.8 1.1 2.5 -0.1 -1.6 -0.9
Forced vital capacity (FVC), Best measure 0.3 1.1 2.3 1.0 1.5 0.0
Body fat percentage 0.4 1.6 2.5 0.5 1.6 -1.5
Leg fat percentage (right) 0.7 2.4 6.4 0.7 2.5 -0.6
Arm fat-free mass (right) 1.7 8.7 22.5 -1.5 -4.7 -1.1
Exposure to tobacco smoke outside home 0.4 0.5 1.3 0.4 1.1 -0.3
Comparative body size at age 10 2.4 6.5 17.0 1.1 -4.1 -1.2
Number of full brothers 0.4 0.5 1.1 -0.5 1.0 0.2
Worry too long after embarrassment 1.2 1.9 3.2 1.8 0.8 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.2 -1.8 -1.0 -0.8
Wheeze or whistling in the chest in last year 0.3 0.5 1.4 -1.2 -0.3 -0.2
Number of children fathered 3.2 3.6 8.5 -2.9 0.6 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 -0.3 1.4 -0.3
Age at first live birth 0.2 0.3 0.7 -0.0 -0.4 0.8
Pulse wave peak to peak time 0.1 0.1 0.2 -0.3 -0.0 0.5
Health satisfaction 2.5 3.2 5.2 2.0 0.5 -2.3
Shortness of breath walking on level ground 0.0 0.0 0.1 0.1 0.3 -0.1
Qualifications: College or University degree 0.6 1.8 2.5 -1.4 -1.0 1.6
Eye problems/disorders: None of the above 0.7 0.8 1.1 -0.9 -0.6 1.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.0 1.0 1.7 -0.3
Emphysema/chronic bronchitis 0.5 0.5 1.1 1.1 0.7 0.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.4 -0.6 0.5 0.5
Neck or shoulder pain in last month 0.6 0.9 1.5 1.0 0.1 -1.2
Medication: Blood pressure 0.1 0.3 0.4 0.3 -0.6 -0.5
Angina (self-reported) 0.1 0.1 0.2 0.4 -0.3 0.1
Migraine (self-reported) 0.8 1.0 2.4 0.6 1.5 -0.6
Medication: Ibuprofen 0.1 0.1 0.4 0.6 0.1 0.1
Medication: Allopurinol 0.5 0.7 1.6 -0.4 -1.3 -0.3
Medication: Omeprazole 0.9 1.0 1.7 -1.2 0.4 1.3
Medication: Seretide 50 evohaler 0.7 0.8 1.3 -0.7 -0.7 1.1
Mean time to correctly identify matches 0.1 0.2 0.5 -0.1 -0.7 -0.3
Heart disease (mother) 0.4 0.5 1.1 -0.4 1.0 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.9 -0.7 -1.4 0.7
Whole body fat mass 0.2 0.9 2.6 0.0 -0.3 -1.6
Leg fat mass (right) 0.2 0.8 2.2 0.3 -0.3 -1.5
Arm predicted mass (right) 1.6 8.4 21.6 -1.3 -4.7 -1.4
Pulse rate, automated reading 0.4 1.3 1.9 1.4 0.2 -1.4
Alcohol intake frequency. 0.3 0.7 1.4 1.2 -0.1 -0.8
Comparative height size at age 10 0.8 4.4 9.0 -0.5 -3.0 -2.0
Number of full sisters 0.1 0.2 0.3 0.5 -0.3 -0.4
Suffer from ‘nerves’ 1.7 2.7 3.3 1.6 1.5 -1.8
Overall health rating 0.5 1.1 1.6 1.3 -1.0 -0.9
Chest pain or discomfort 0.3 0.5 1.3 -1.1 -0.4 0.0
Had major operations 1.0 1.1 3.1 0.3 -1.8 -0.5
Age at last live birth 0.1 0.2 0.4 0.3 0.7 -0.1
Family relationship satisfaction 0.8 1.0 2.5 1.6 -0.6 -0.3
Leg pain on walking 2.3 2.9 5.2 1.8 0.3 -2.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.2 -0.2 0.4 0.5
Commuting to job workplace: Car/motor vehicle 0.5 0.5 0.9 0.0 0.9 -0.9
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.5 1.2 -0.1 -1.1
Medication: Aspirin 0.5 0.7 1.4 -0.6 -1.2 0.6
Supplements: Vitamin C 1.8 2.1 4.0 -1.4 -2.0 0.5
Knee pain experienced in last month 0.8 1.2 2.3 1.0 -0.5 -1.5
Hypertension (Self-reported) 0.1 0.3 0.9 -0.2 -0.9 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.3 -0.4 1.1 -0.3
Illnesses of father: Heart disease 0.7 1.0 2.1 -1.4 -0.6 0.7
Illnesses of siblings: Diabetes 0.5 0.7 0.7 -0.8 0.8 0.8
Smoking status: Previous 1.2 1.8 3.6 -1.9 1.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.2 1.1 -0.9 -0.5
Whole body fat-free mass 2.2 12.3 32.1 -1.5 -5.7 -1.6
Leg fat-free mass (right) 2.4 12.8 31.7 -1.7 -5.6 -1.9
Arm fat percentage (left) 0.4 1.7 4.9 0.4 0.3 -2.2
Average weekly red wine intake 0.4 0.5 1.0 -0.2 -0.7 -1.0
Handedness (chirality/laterality): Left-handed 1.3 1.5 4.1 0.7 2.0 0.1
Mood swings 0.6 1.1 1.8 1.3 -0.6 -1.1
Loneliness, isolation 0.7 1.0 2.2 0.2 1.5 -0.9
Long-standing illness, disability or infirmity 0.5 0.7 1.9 0.1 -1.4 -0.4
Ever had bowel cancer screening 0.2 0.2 0.3 0.5 -0.3 -0.6
Diabetes diagnosed by doctor 0.9 1.5 3.0 0.2 -1.7 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.5 0.4 0.2
Friendships satisfaction 0.8 1.0 2.2 1.5 -0.8 0.1
Qualifications: nursing, teaching 0.4 0.6 1.3 0.6 -1.2 -0.2
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.1 0.7 -0.4
Eye problems/disorders: Cataract 1.8 2.1 3.8 1.6 0.3 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.2 -0.4 1.8 0.7
Medication for cholesterol 0.4 0.6 1.7 -0.3 1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.4 0.6 -0.3 -0.2
Back pain experienced in last month 0.8 1.1 2.0 1.4 1.1 -0.3
Mineral and other dietary supplements 0.7 0.9 2.5 -0.4 -0.3 1.6
Breast cancer (self-reported) 2.4 2.8 5.4 -2.3 -0.4 1.7
Asthma (self-reported) 0.3 0.7 1.9 -1.4 -0.2 0.3
Osteoporosis (self-reported) 0.6 0.7 1.8 0.4 -1.3 0.4
Osteoarthritis (self-reported) 0.9 1.2 1.7 -1.3 -1.2 0.6
Medication: Aspirin 0.8 1.0 1.4 -0.8 -1.0 1.2
Medication: Gliclazide 1.0 1.1 2.1 -1.1 0.2 1.4
Illnesses of father: None of the above (group 1) 1.1 1.4 2.0 1.0 1.4 -1.0
Smoking status: Current 0.4 0.6 1.2 -0.6 -0.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 8.9 1.0 3.0 0.2
Whole body water mass 2.2 12.7 33.1 -1.5 -5.8 -1.7
Leg predicted mass (right) 2.5 13.3 33.3 -1.7 -5.8 -1.9
Arm fat mass (left) 0.5 2.2 4.1 -0.1 -1.5 -2.0
Number of self-reported non-cancer illnesses 0.7 1.2 3.3 -0.7 -1.8 0.1
Average weekly champagne plus white wine intake 0.5 0.7 1.1 1.1 0.7 -0.8
Miserableness 0.8 1.5 2.8 1.2 0.4 -1.7
Guilty feelings 1.6 2.5 3.3 -1.8 -1.5 1.4
Wears glasses or contact lenses 0.3 0.4 0.8 -0.9 -0.2 0.6
Ever taken oral contraceptive pill 1.5 1.7 4.1 -2.0 -0.7 0.6
Hearing aid user 0.9 1.0 2.8 -1.7 -0.1 0.5
Mother’s age at death 0.2 0.2 0.2 -0.5 -0.4 -0.5
Financial situation satisfaction 0.5 0.6 0.8 0.7 -0.7 -0.9
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 1.1 0.1 -0.3
Commuting to job workplace: Public transport 0.6 0.7 1.0 -1.0 -0.7 0.8
Eye problems/disorders: Glaucoma 0.2 0.2 0.6 -0.3 0.7 0.2
Medication: Blood pressure 0.3 0.6 1.2 0.7 -0.2 -1.1
Pain type(s) experienced in last month: Hip pain 2.1 2.7 3.6 1.9 1.8 -1.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 0.3 -0.0 -1.0
High cholesterol (Self-reported) 2.0 3.6 7.8 -1.7 -0.3 2.8
Medication: Bendroflumethiazide 0.0 0.0 0.1 -0.1 0.2 0.1
Medication: Paracetamol 0.6 0.9 2.2 1.5 0.5 -0.4
Medication: Lisinopril 0.7 0.9 1.8 -0.5 1.4 0.8
Medication: Atorvastatin 0.6 0.8 1.2 -1.1 -0.2 1.0
Illnesses of father: High blood pressure 1.4 1.7 2.7 -1.6 0.4 1.5
Alcohol drinker status: Never 0.2 0.2 0.4 0.5 0.0 0.6
Ever smoked 0.4 0.7 2.0 -1.4 0.2 0.3
Basal metabolic rate 1.8 9.8 25.3 -1.2 -5.0 -1.6
Leg fat percentage (left) 0.6 2.3 6.6 0.5 2.6 -0.3
Arm fat-free mass (left) 1.5 7.7 20.4 -0.9 -4.5 -1.4
Number of operations (self-reported) 0.8 1.2 2.2 0.2 -1.5 -1.1
Average weekly beer plus cider intake 0.7 1.1 2.2 1.0 1.5 0.1
Irritability 0.1 0.1 0.3 0.5 0.0 -0.1
Risk taking 0.8 1.1 1.9 -1.4 0.4 1.1
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.2 -1.0 -1.1 0.7
Fractured/broken bones in last 5 years 0.8 1.1 2.1 -1.4 -0.3 1.0
Age started oral contraceptive pill 0.4 0.5 1.3 0.0 -1.1 -0.4
Diastolic blood pressure, automated reading 0.2 0.5 0.7 -0.7 -0.9 -0.5
Ever depressed for a whole week 0.8 1.0 1.5 -1.2 1.0 -0.5
Unable to work because of sickness or disability 0.6 0.7 1.4 -0.9 -0.2 1.2
Commuting to job workplace: Cycle 0.6 0.8 1.4 -1.2 -0.9 -0.1
Myopia 0.8 1.1 3.2 1.8 0.3 -0.4
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.4 -0.2 1.5 0.0
Cholesterol lowering medication 0.1 0.2 0.4 0.6 0.0 0.3
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.7 -1.6 -0.9 1.1
Pain experienced in last month 1.1 1.9 4.5 -2.1 -0.0 1.0
Supplements: Calcium 1.9 2.1 4.0 -1.1 1.0 2.0
Basal cell carcinoma (self-reported) 0.3 0.4 1.1 -1.1 -0.0 -0.1
Heart attack/myocardial infarction (self-reported) 0.8 1.1 3.1 0.1 -1.8 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.2 1.4 0.0 -1.5
Heart disease (siblings) 0.3 0.4 1.1 0.1 1.0 -0.4
Alcohol drinker status: Previous 0.6 0.6 1.3 0.4 -0.7 -1.1
Pack years of smoking 0.1 0.1 0.2 -0.5 -0.1 0.0
Impedance of whole body 2.6 13.0 34.6 2.0 5.9 0.7
Leg fat mass (left) 0.2 0.7 2.0 0.2 -0.3 -1.4
Arm predicted mass (left) 1.4 7.1 18.9 -0.7 -4.3 -1.4