TWAS hub - CCDC114

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0340	1.9e-05	0.046	0.042	0.052	0.052	0.048	2.5e-06	6.1e-06	5.2e-07	5.6e-07	1.6e-06
2	METSIM	Adipose	0.1363	0.0300	8.7e-13	0.131	0.094	0.113	0.119	0.122	4.8e-19	7.2e-14	1.7e-16	2.1e-17	8.4e-18
3	TCGA	Breast Invasive Carcinoma	0.0132	0.0075	3.3e-03	0.010	0.012	0.008	NA	0.008	3.5e-03	1.3e-03	8.0e-03	NA	6.6e-03
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0256	0.0149	5.3e-03	0.018	0.008	0.009	NA	0.010	3.6e-03	3.9e-02	2.7e-02	NA	2.4e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0619	0.0284	3.4e-05	0.035	0.036	0.026	NA	0.048	8.1e-05	5.7e-05	5.6e-04	NA	4.3e-06
6	TCGA	Brain Lower Grade Glioma	0.2471	0.0633	1.7e-16	0.090	0.161	0.157	NA	0.158	2.2e-10	6.5e-18	1.7e-17	NA	1.3e-17
7	TCGA	Liver Hepatocellular Carcinoma	0.1180	0.0550	8.0e-04	0.101	0.060	0.063	NA	0.080	1.8e-05	8.9e-04	6.5e-04	NA	1.4e-04
8	TCGA	Lung Adenocarcinoma	0.0721	0.0297	6.1e-08	0.041	0.062	0.064	NA	0.065	1.3e-05	8.2e-08	6.2e-08	NA	4.1e-08
9	TCGA	Lung Squamous Cell Carcinoma	0.0270	0.0145	2.8e-03	0.018	0.020	0.017	NA	0.014	3.2e-03	2.0e-03	4.8e-03	NA	8.8e-03
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.0460	0.0270	6.8e-03	0.005	0.015	-0.002	NA	0.002	1.5e-01	3.2e-02	4.5e-01	NA	2.1e-01
11	TCGA	Prostate Adenocarcinoma	0.0352	0.0219	9.6e-03	0.009	0.016	0.010	NA	0.007	3.8e-02	7.4e-03	2.7e-02	NA	6.0e-02
12	TCGA	Soft Tissue Sarcoma	0.0880	0.0490	6.1e-03	0.065	0.036	0.047	NA	0.052	1.1e-04	3.1e-03	8.5e-04	NA	4.6e-04
13	TCGA	Thyroid Carcinoma	0.1240	0.0450	1.2e-09	0.057	0.099	0.071	NA	0.083	2.8e-06	7.8e-10	2.0e-07	NA	1.9e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Coronary Artery Disease (CAD)	7.6	9.0	14.3	-2.7	-3.4	-3.3	-3.7	-3.8	-1.9	-3.0	-3.3	-3.2	-3.2	-2.3	-0.4	-3.3
Osteoarthritis (self-reported)	5.7	7.4	11.1	-2.6	-3.1	-2.5	-3.3	-3.3	-1.7	-3.0	-3.0	-2.6	-2.4	-3.1	-2.0	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	5.3	6.2	8.8	-2.9	-2.7	-2.0	-3.0	-3.0	-2.2	-2.5	-2.8	-2.8	-2.5	-1.6	-0.4	-2.9
Qualifications: O levels/GCSEs or equivalent	3.9	6.2	9.4	2.1	3.0	2.0	2.9	2.8	1.5	3.1	2.4	1.8	2.2	3.0	2.9	2.1
Mouth/teeth dental problems: Loose teeth	3.6	4.2	6.3	2.5	2.3	1.0	2.4	2.4	1.7	2.4	2.0	1.8	1.4	2.1	2.2	1.9
Length of working week for main job	3.5	3.9	8.7	2.2	1.9	0.9	2.1	2.1	2.9	1.9	2.0	1.8	1.7	2.0	1.2	1.9
Hand grip strength (right)	3.4	9.3	12.2	3.4	3.3	3.2	3.2	3.1	2.2	3.4	3.1	2.5	3.5	3.0	2.8	2.6
Townsend deprivation index at recruitment	3.2	4.5	6.7	-1.3	-2.3	-2.6	-2.3	-2.3	-1.9	-1.9	-2.6	-2.2	-2.3	-2.1	-0.7	-2.1
Shortness of breath walking on level ground	3.2	3.8	7.8	-1.0	-2.3	-2.0	-2.8	-2.8	-0.6	-2.0	-2.1	-2.3	-2.1	-1.4	-0.6	-1.4
Hearing aid user	2.8	3.2	5.1	1.8	1.9	1.4	2.1	2.2	1.4	1.8	2.1	2.2	1.8	1.0	0.7	1.9
Crohns Disease (2012)	2.6	4.2	6.4	2.5	2.5	1.3	2.5	2.4	1.4	2.5	2.2	2.3	2.0	1.0	1.2	2.0
Other serious medical condition/disability diagnosed by doctor	2.6	3.3	4.5	-2.0	-1.9	-1.6	-2.1	-2.1	-1.8	-1.9	-2.0	-1.9	-1.9	-1.8	-0.7	-1.5
Average weekly fortified wine intake	2.6	3.0	4.9	2.1	1.6	1.8	1.5	1.4	1.8	1.7	2.1	1.5	1.9	2.2	1.2	1.6
Ulcerative Colitis	2.5	3.6	6.5	-2.0	-2.1	-2.1	-2.0	-1.9	-0.3	-2.2	-2.4	-1.8	-2.6	-1.5	-0.9	-1.7
Birth weight	2.5	5.4	7.9	-2.6	-2.4	-2.5	-2.4	-2.4	-1.2	-2.4	-2.8	-2.8	-2.8	-1.2	-1.0	-2.7
Alcohol drinker status: Previous	2.5	2.9	4.7	1.6	1.5	1.0	1.9	2.1	1.5	1.5	1.9	1.8	1.2	1.8	1.8	2.2
Illnesses of father: Heart disease	2.3	3.2	5.5	1.8	1.7	1.5	1.6	1.8	2.2	1.6	2.3	2.2	1.6	1.3	1.0	2.2
Loneliness, isolation	2.3	3.2	9.6	-0.8	-1.1	-3.1	-1.5	-1.8	-1.6	-0.6	-2.0	-2.4	-2.5	-0.8	0.4	-2.2
Chest pain or discomfort	2.2	3.2	8.0	2.2	1.0	1.4	1.4	1.6	2.8	1.0	1.9	2.1	1.8	1.2	0.4	2.8
Ulcerative Colitis (UC)	2.1	3.9	7.5	-2.7	-1.8	-1.5	-1.8	-1.8	-1.9	-2.0	-2.2	-1.5	-2.1	-2.4	-1.6	-1.8
Schizophrenia (2014)	2.1	4.5	9.1	-2.0	-3.0	-1.6	-2.7	-2.7	-0.7	-2.9	-2.2	-2.1	-2.1	-1.1	-1.4	-1.7
Blood Platelet Count	2.1	24.1	41.5	4.5	5.2	5.2	5.7	5.8	2.3	4.7	5.8	6.4	5.3	2.2	0.6	6.0
Lung cancer (father)	2.1	2.5	3.6	-1.9	-1.8	-1.4	-1.8	-1.8	-0.6	-1.9	-1.9	-1.5	-1.3	-1.4	-1.7	-1.3
Depression (self-reported)	2.0	2.4	9.4	-0.5	-0.4	-3.1	-0.8	-1.0	-0.3	-0.1	-1.3	-2.0	-2.7	0.6	1.7	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.7	-1.4	-1.8	-2.4	-2.0	-2.0	-0.4	-1.7	-2.0	-2.4	-2.2	-0.1	0.0	-1.9
Medication: Amlodipine	2.0	2.8	5.3	1.3	1.2	1.8	2.0	2.2	2.3	0.7	1.5	1.5	1.4	2.2	-0.6	1.9
Blood White Count	1.7	12.7	20.5	3.1	3.9	4.1	4.3	4.4	0.8	3.6	4.3	4.5	4.3	1.0	-0.0	3.7
Miserableness	1.7	3.0	4.6	-1.7	-1.9	-2.0	-2.0	-1.9	-0.7	-1.9	-1.8	-2.0	-2.0	-0.6	-0.9	-2.1
Ovarian Cancer	1.6	2.1	3.7	1.5	1.9	0.6	1.6	1.4	1.5	1.9	1.2	0.9	1.0	1.3	1.7	1.5
Maternal smoking around birth	1.6	2.3	4.8	1.3	1.6	1.4	1.8	1.8	0.5	1.3	1.6	2.2	1.8	-0.0	0.1	2.0
Had menopause	1.6	1.9	3.8	-1.2	-1.2	-1.7	-1.3	-1.4	-1.7	-0.9	-1.2	-1.1	-1.6	-2.0	-0.6	-1.7
Qualifications: None of the above	1.6	3.3	5.5	-1.1	-1.8	-2.3	-2.1	-2.2	-1.2	-1.7	-2.0	-1.8	-2.1	-1.9	-1.2	-1.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	3.5	-1.2	-1.7	-1.9	-1.8	-1.7	0.3	-1.7	-1.3	-1.2	-1.7	-0.6	-1.3	-1.3
Hand grip strength (left)	1.5	4.0	5.5	2.3	2.1	2.1	2.1	1.9	1.5	2.3	1.9	1.4	2.4	2.1	2.3	1.4
Multivitamins +/- minerals	1.5	1.9	3.4	1.4	1.1	1.6	1.4	1.6	0.8	1.1	1.6	1.9	1.6	0.5	0.8	1.8
Illnesses of mother	1.5	1.9	3.2	1.3	1.3	1.1	1.3	1.4	1.7	1.1	1.6	1.6	1.2	1.2	0.9	1.8
Eye problems/disorders: Glaucoma	1.5	1.8	6.2	-1.6	-1.6	-0.1	-1.2	-1.0	-1.1	-1.9	-0.9	-0.4	-0.7	-1.6	-2.5	-0.8
Bipolar Disorder or Schizophrenia	1.4	3.3	6.7	-1.5	-2.6	-1.4	-2.5	-2.4	-0.6	-2.3	-1.8	-1.9	-1.9	-1.0	-1.0	-1.5
Relative age voice broke	1.4	2.1	3.0	-1.6	-1.5	-1.2	-1.7	-1.7	-1.6	-1.5	-1.7	-1.4	-0.9	-1.3	-1.3	-1.3
Medication: Aspirin	1.4	1.8	3.5	-1.2	-1.9	-0.7	-1.7	-1.6	-1.2	-1.8	-1.4	-1.2	-1.0	-1.1	-1.0	-1.3
Long-standing illness, disability or infirmity	1.4	2.1	4.0	-1.3	-1.8	-1.2	-1.7	-1.6	-0.9	-2.0	-1.2	-0.9	-1.4	-1.6	-2.0	-0.6
Illnesses of father: High blood pressure	1.4	1.7	3.5	1.6	1.6	0.3	1.9	1.7	0.7	1.7	0.8	1.0	0.9	0.7	1.5	1.2
Bipolar Disorder (2018)	1.3	2.0	5.6	-1.0	-1.1	-1.5	-1.6	-1.6	-0.8	-0.9	-1.7	-2.4	-1.8	-0.5	-0.1	-1.7
Alzheimer’s Disease (including proxy)	1.3	1.9	2.7	-1.3	-1.5	-1.2	-1.4	-1.4	-1.6	-1.5	-1.5	-1.3	-1.6	-1.5	-0.8	-1.3
Sensitivity / hurt feelings	1.3	2.2	4.1	-1.4	-2.0	-1.4	-1.8	-1.7	-0.7	-2.0	-1.6	-1.2	-1.5	-1.4	-0.8	-1.3
Hayfever, allergic rhinitis or eczema	1.3	2.8	6.1	1.6	2.5	0.8	2.4	2.2	1.2	2.3	1.7	1.5	1.2	1.1	0.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	8.2	1.7	2.2	0.1	1.6	1.4	2.0	2.2	1.0	0.4	0.5	2.0	2.9	1.2
Commuting to job workplace: Cycle	1.3	1.6	2.8	-1.5	-1.4	-0.2	-1.1	-1.1	-1.7	-1.6	-1.0	-0.9	-1.1	-1.3	-1.5	-1.5
Triglycerides	1.2	2.0	3.6	-1.6	-1.6	-1.0	-1.7	-1.6	-0.9	-1.5	-1.5	-1.9	-1.8	0.0	-0.3	-1.6
Alcohol intake versus 10 years previously	1.2	1.8	7.2	-1.7	-1.2	-0.6	-1.2	-1.2	-2.1	-1.0	-1.1	-0.6	-0.9	-2.7	-1.1	-0.7
Headache pain in last month	1.2	2.0	3.9	1.8	1.3	0.5	1.4	1.4	1.7	1.4	1.3	1.1	1.0	1.7	1.4	2.0
Exposure to tobacco smoke outside home	1.2	1.6	4.7	1.7	1.3	-0.2	1.4	1.4	1.2	1.4	1.2	0.8	0.2	2.2	1.5	0.7
Medication: Allopurinol	1.2	1.6	5.5	1.0	1.3	0.7	1.6	1.6	1.6	1.1	0.8	0.5	0.6	2.3	0.6	1.1
Had major operations	1.2	1.4	2.5	-1.2	-1.6	-0.3	-1.4	-1.3	-1.2	-1.5	-1.1	-0.9	-0.6	-1.3	-1.4	-0.9
Illnesses of siblings: Diabetes	1.2	1.4	5.5	0.6	1.0	2.3	0.9	1.0	-0.3	1.0	1.3	1.1	2.1	0.9	-0.2	1.1
Prostate Cancer	1.1	1.6	2.8	1.2	1.4	1.3	1.6	1.7	1.0	1.2	1.1	1.1	1.5	1.2	0.6	1.2
Lupus	1.1	1.6	3.2	1.8	1.6	-0.9	1.2	1.0	1.6	1.8	0.4	0.2	0.1	1.6	1.8	0.7
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.3	1.0	1.5	0.2	1.5	1.4	1.4	1.4	0.9	1.1	0.9	1.0	0.7	0.9
Supplements: Zinc	1.1	1.2	2.1	-0.9	-1.4	-0.8	-1.4	-1.4	-0.8	-1.4	-1.2	-1.1	-1.1	-0.9	-0.7	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	5.6	-0.6	-0.8	-2.4	-0.9	-1.0	-0.3	-0.7	-1.1	-1.2	-1.9	-0.9	-0.9	-1.3
Number of incorrect matches in round	1.1	1.9	6.0	-1.5	-1.7	-0.6	-1.5	-1.3	-1.0	-1.8	-1.4	-0.6	-1.0	-2.4	-0.8	-0.4
Number of live births	1.1	1.5	7.9	-0.1	0.3	-1.8	-0.0	-0.3	0.6	0.5	-1.2	-1.6	-1.3	1.0	2.8	-1.0
Qualifications: A levels/AS levels or equivalent	1.1	2.3	5.5	1.0	1.3	2.1	1.4	1.6	1.1	1.2	2.1	1.5	1.4	2.3	-0.1	1.4
Breastfed as a baby	1.1	1.3	7.4	-1.5	0.2	1.0	0.4	0.3	-2.7	0.0	-0.1	-0.2	0.4	-1.6	-1.5	-1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.5	-1.5	-0.8	-0.0	-0.6	-0.6	-1.8	-1.0	-1.0	-0.3	-0.2	-2.1	-1.8	-0.6
Medication: Seretide 50 evohaler	1.1	1.2	7.8	1.8	0.4	-0.3	0.2	0.3	2.8	0.6	0.8	0.4	0.1	1.0	0.7	1.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.8	-1.2	-1.6	-0.0	-1.2	-1.0	-0.2	-1.8	-1.1	-1.1	-0.8	-0.5	-1.9	-0.8
Myopia	1.1	1.6	2.5	1.2	1.6	0.8	1.5	1.5	1.1	1.4	1.2	1.0	0.7	1.5	1.2	1.1
Rheumatoid Arthritis	1.0	1.3	3.1	-0.9	-1.8	-0.5	-1.5	-1.4	-0.4	-1.7	-1.2	-1.4	-0.9	-0.2	-0.9	-0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.3	-1.1	-0.9	-1.4	-1.2	-1.2	-0.8	-0.8	-1.3	-1.5	-1.4	-0.8	-0.3	-1.5
Medication: Metformin	1.0	1.4	2.9	0.6	1.2	1.7	1.1	1.1	0.4	1.0	1.4	1.7	1.7	-0.1	-0.0	1.6
Taking other prescription medications	1.0	1.6	2.9	-1.1	-1.6	-0.8	-1.7	-1.7	-0.6	-1.6	-1.3	-1.4	-1.3	-0.7	-1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.7	1.4	1.5	0.7	1.6	1.6	1.0	1.5	1.2	1.2	0.9	1.0	1.1	1.4
Illnesses of father: None of the above (group 1)	1.0	1.2	2.4	-1.5	-0.8	-0.9	-1.1	-1.1	-1.1	-0.8	-1.3	-1.6	-1.2	-0.2	-0.0	-1.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	1.3	0.6	0.9	0.9	1.1	1.4	0.6	1.5	1.5	1.2	0.7	-0.0	1.4
Schizophrenia (2018)	0.9	1.8	5.8	-1.1	-2.4	-0.6	-1.9	-1.7	-0.0	-2.3	-0.9	-0.6	-1.0	-0.9	-1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.6	-0.8	-0.8	-0.5	-1.0	-1.0	-2.1	-0.6	-0.8	-0.7	-0.7	-1.7	-0.9	-0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	5.8	0.1	-0.1	-2.4	-0.7	-0.9	-0.4	0.1	-1.0	-1.5	-1.5	-0.2	0.6	-1.4
Impedance of arm (right)	0.9	4.1	9.0	-3.0	-2.4	0.3	-2.1	-1.9	-2.3	-2.8	-1.5	-1.0	-1.1	-2.1	-2.6	-1.2
Hair/balding pattern: Pattern 3	0.9	1.4	2.0	1.1	1.2	1.1	1.4	1.4	1.4	1.0	1.1	1.1	1.3	0.7	0.6	1.4
Hair/balding pattern: Pattern 4	0.9	2.1	3.7	-1.5	-1.3	-1.9	-1.4	-1.4	-0.8	-1.3	-1.4	-1.3	-1.9	-1.1	-1.2	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.9	-0.4	-0.8	-2.0	-1.2	-1.2	-0.2	-0.5	-1.1	-1.7	-1.5	0.1	0.5	-1.2
Number of children fathered	0.9	1.0	3.1	0.5	1.4	-0.2	1.0	0.9	1.1	1.3	0.6	0.4	0.5	1.4	1.8	0.4
Health satisfaction	0.9	1.2	3.9	-0.4	-1.0	-2.0	-1.4	-1.5	-0.0	-0.6	-1.3	-1.4	-1.3	-0.3	0.2	-0.8
Neck or shoulder pain in last month	0.9	1.2	4.1	0.7	0.2	1.6	0.3	0.5	0.7	0.1	1.2	1.7	1.6	-1.0	-0.5	2.0
Migraine (self-reported)	0.9	1.1	2.6	1.3	1.1	0.5	0.9	0.8	1.6	1.0	0.9	0.9	0.7	1.0	0.9	1.5
Friendships satisfaction	0.9	1.2	2.2	1.1	1.5	-0.5	1.5	1.4	0.8	1.5	0.7	0.5	0.1	1.2	1.4	0.4
Crohns Disease (2017)	0.8	1.7	3.1	1.3	1.7	0.9	1.6	1.7	0.6	1.6	1.5	1.7	1.0	0.4	1.0	1.0
Diabetes (mother)	0.8	1.0	4.3	-0.3	-0.8	1.6	-0.5	-0.4	-1.4	-0.7	0.3	0.5	1.0	-1.0	-2.1	0.3
Medication: Atenolol	0.8	1.0	2.3	-1.0	-1.4	-0.2	-1.2	-1.0	-1.0	-1.5	-0.6	-0.0	-0.6	-1.5	-1.0	-0.4
Sitting height	0.8	5.4	28.6	1.7	2.2	-1.5	1.1	0.8	2.4	2.6	0.2	-1.3	-0.4	3.8	5.3	-0.1
Peak expiratory flow (PEF)	0.8	1.9	7.9	1.5	1.0	-1.3	0.5	0.3	1.7	1.2	0.2	-0.6	-0.4	2.4	2.8	-0.3
High blood pressure (siblings)	0.8	1.1	2.1	1.2	1.1	0.4	1.2	1.2	1.0	1.1	1.0	0.8	0.7	1.5	1.2	0.9
Qualifications: College or University degree	0.8	2.6	5.1	1.3	1.6	1.6	1.8	2.0	1.6	1.5	2.0	1.5	1.3	2.2	1.1	1.2
Arm predicted mass (right)	0.8	3.9	18.2	1.9	2.1	-1.1	1.4	1.1	1.8	2.6	0.4	-0.7	0.0	3.1	4.3	-0.1
Medication: Gliclazide	0.8	0.9	2.0	-1.2	-0.0	-1.2	-0.3	-0.5	-0.9	0.1	-1.0	-1.2	-1.0	0.2	1.2	-1.4
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-1.1	-1.3	-0.8	-0.9	-0.8	-0.8	-1.3	-0.9	-0.2	-0.7	-1.5	-1.0	-0.2
Alzheimer’s Disease (in mother)	0.7	0.9	1.8	-0.7	-0.8	-1.2	-0.9	-1.0	-0.9	-0.7	-1.0	-0.9	-1.2	-1.3	-0.4	-0.6
HbA1C	0.7	0.8	2.8	0.5	0.5	1.7	0.7	0.8	0.5	0.2	0.9	1.1	1.3	0.2	-0.7	1.0
Hearing difficulty/problems: Yes	0.7	1.0	2.6	0.9	0.9	1.0	1.0	1.1	1.6	0.8	1.2	0.8	0.8	1.3	0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.3	-0.5	-0.8	-1.8	-0.9	-0.9	-1.0	-0.6	-0.8	-1.3	-1.7	-0.1	-0.3	-1.2
Medication: Cholesterol lowering	0.7	1.1	3.2	-0.1	-0.3	-1.5	-0.4	-0.5	0.3	-0.2	-1.2	-1.5	-1.3	1.0	1.8	-1.1
Impedance of arm (left)	0.7	3.2	7.5	-2.7	-2.1	0.3	-1.7	-1.5	-2.1	-2.4	-1.3	-0.7	-0.8	-2.2	-2.5	-0.8
Pulse wave reflection index	0.7	0.9	1.8	-0.9	-0.5	-1.4	-0.6	-0.7	-1.2	-0.6	-0.9	-0.6	-1.1	-1.3	-0.0	-1.2
Arm fat-free mass (right)	0.7	3.6	17.8	1.7	1.9	-1.2	1.2	0.9	1.4	2.5	0.1	-1.0	-0.1	2.9	4.2	-0.4
Mean time to correctly identify matches	0.7	1.4	4.7	-1.4	-0.6	-0.9	-0.5	-0.6	-2.2	-0.6	-0.5	-0.5	-1.1	-1.7	-1.2	-1.7
Smoking status: Previous	0.7	1.1	2.2	-1.0	-0.8	-1.3	-1.4	-1.5	-0.5	-0.8	-0.9	-1.2	-1.2	-0.4	-0.8	-1.2
Medication for cholesterol	0.7	1.0	2.0	-0.9	-1.2	-1.2	-1.0	-0.9	-0.5	-1.3	-0.9	-0.5	-1.4	-1.4	-0.6	-0.5
Medication: Aspirin	0.7	1.0	1.7	-0.7	-1.3	-0.6	-1.3	-1.2	-0.8	-1.2	-1.0	-1.1	-0.9	-0.6	-0.4	-1.1
Fractured/broken bones in last 5 years	0.7	0.9	2.0	1.4	0.9	0.8	0.9	0.8	0.6	1.0	1.0	0.9	1.0	0.8	0.9	1.1
Arm predicted mass (left)	0.7	3.6	17.6	1.6	1.8	-1.3	0.9	0.6	1.6	2.3	0.0	-1.2	-0.3	3.3	4.2	-0.5
Fasting Glucose	0.6	0.7	2.0	-0.3	-0.7	-0.9	-0.7	-0.8	0.5	-0.5	-0.8	-1.2	-1.0	1.2	1.4	-0.5
Chronotype (morning person)	0.6	1.4	3.4	-1.6	-1.1	0.2	-1.1	-1.0	-1.7	-1.2	-0.8	-0.8	-0.7	-1.5	-1.9	-1.0
Stomach or abdominal pain in last month	0.6	0.8	3.3	0.5	0.9	0.7	0.9	1.0	-0.5	0.8	0.6	0.7	0.6	0.4	1.8	0.8
Heart attack	0.6	0.8	1.8	-0.7	-0.7	-1.3	-1.0	-1.2	-0.9	-0.5	-1.0	-0.8	-0.7	-1.3	-0.3	-0.6
Trunk fat-free mass	0.6	3.2	16.8	1.3	1.7	-1.3	0.9	0.6	1.4	2.1	-0.1	-1.2	-0.3	3.1	4.1	-0.8
Pulse rate	0.6	1.0	2.7	0.9	0.1	1.6	0.2	0.2	1.3	0.3	0.9	0.5	1.2	1.5	0.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	1.0	0.5	1.2	0.7	0.9	0.5	0.4	1.0	1.0	0.8	0.5	-0.4	1.1
Trunk predicted mass	0.6	3.2	16.6	1.3	1.7	-1.3	0.9	0.6	1.3	2.2	-0.1	-1.2	-0.3	3.1	4.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	0.4	1.0	1.5	0.8	0.8	-0.5	1.0	1.3	1.4	1.4	-0.3	-0.5	0.8
Gout (self-reported)	0.6	0.9	4.3	0.8	0.7	0.7	1.1	1.2	1.2	0.5	0.5	0.3	0.4	2.1	0.2	0.9
Pulse rate, automated reading	0.6	1.9	7.2	2.0	0.5	0.7	0.1	0.1	2.1	0.9	1.0	-0.1	0.7	2.7	2.3	1.1
Family relationship satisfaction	0.6	0.7	3.2	-0.2	0.3	-1.3	0.0	-0.2	-0.9	0.6	-0.6	-0.9	-1.0	-0.0	1.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.3	0.4	0.5	1.5	0.5	0.6	0.2	0.5	1.1	1.2	1.2	0.2	0.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.3	0.9	0.9	-0.6	0.5	0.4	1.0	1.0	0.0	-0.4	-0.0	1.5	1.5	0.0
Medication: Atorvastatin	0.6	0.8	2.5	-1.1	-0.9	-0.1	-0.9	-1.0	-1.6	-0.9	-0.9	-0.5	-0.4	-1.2	-0.6	-0.4
Arm fat-free mass (left)	0.6	3.2	16.2	1.5	1.7	-1.3	0.9	0.6	1.3	2.2	0.0	-1.1	-0.2	3.0	4.0	-0.6
Diastolic blood pressure, automated reading	0.6	1.9	6.4	2.1	0.7	0.6	0.7	0.6	2.5	0.8	0.8	0.6	1.1	2.2	1.4	1.3
Ever depressed for a whole week	0.6	0.8	3.0	0.5	0.2	-1.7	-0.3	-0.5	0.1	0.6	-0.3	-1.2	-0.8	0.8	1.2	-1.2
Depressed Affect (Nagel 2018)	0.5	1.1	2.1	-0.7	-1.1	-1.4	-1.4	-1.3	-0.5	-0.9	-1.1	-1.3	-1.3	-0.5	0.5	-1.1
Reaction Time	0.5	0.9	3.5	-1.0	-0.1	-0.5	-0.1	-0.2	-1.9	-0.1	-0.2	-0.2	-0.6	-1.6	-1.5	-1.2
Blood Red Count	0.5	4.5	8.4	2.9	2.2	0.3	2.3	2.2	2.6	2.4	1.8	1.3	1.0	2.4	2.9	1.4
Systolic Blood Pressure	0.5	2.6	7.1	1.1	0.5	2.7	1.4	1.8	1.2	0.1	1.5	2.2	2.1	0.7	-1.5	1.9
Allergy or Eczema	0.5	1.4	3.4	0.9	1.8	0.7	1.6	1.5	1.0	1.8	1.1	0.7	0.9	0.9	0.7	0.8
Average weekly spirits intake	0.5	0.6	2.7	0.1	0.5	-1.7	0.2	-0.1	0.2	0.6	-0.8	-0.9	-0.7	0.1	1.2	-0.7
Medication: Co-codamol	0.5	0.6	1.4	-0.9	-0.6	-0.6	-1.1	-1.2	-0.8	-0.4	-0.5	-1.1	-0.7	-0.1	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	1.2	0.0	0.6	-0.2	-0.1	0.9	0.1	1.2	1.1	0.7	0.0	-0.8	1.0
Allergy	0.5	1.3	2.6	-1.4	-1.6	-0.3	-1.5	-1.4	-1.2	-1.6	-1.1	-0.9	-0.5	-0.5	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	8.2	1.4	1.1	-1.5	0.4	0.2	1.3	1.4	0.1	-0.8	-0.5	2.2	2.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	-1.3	-0.9	-0.0	-0.6	-0.6	-0.7	-1.0	-0.6	-0.1	-0.0	-0.8	-1.4	-0.5
Leg pain on walking	0.5	0.7	2.5	0.3	-0.1	-1.1	-0.9	-0.9	-0.1	0.3	-0.3	-1.0	-0.8	0.8	1.6	-0.8
Whole body fat-free mass	0.5	2.8	16.2	1.2	1.6	-1.1	0.8	0.6	1.0	2.1	-0.1	-1.1	-0.1	2.7	4.0	-0.6
Back pain experienced in last month	0.5	0.8	1.9	-1.2	-0.8	-0.1	-0.9	-1.0	-1.4	-0.7	-0.8	-0.5	-0.2	-1.4	-1.1	0.1
Whole body water mass	0.5	2.9	16.4	1.3	1.6	-1.2	0.8	0.6	1.0	2.1	-0.1	-1.1	-0.2	2.7	4.1	-0.7
Basal metabolic rate	0.5	2.5	15.3	1.0	1.3	-1.2	0.5	0.3	0.8	1.8	-0.3	-1.3	-0.3	2.5	3.9	-0.8
Depression (Nagel 2018)	0.4	0.5	2.3	-0.4	-0.3	-1.5	-0.5	-0.5	-0.1	-0.2	-0.6	-0.9	-1.2	0.1	-0.4	-1.1
Breast Cancer	0.4	1.0	2.3	0.3	0.9	1.5	1.0	1.0	-0.3	0.8	1.0	1.4	1.5	-0.8	-0.7	0.8
Blood Eosinophil Count	0.4	2.8	5.5	1.9	1.2	1.2	1.8	2.1	2.1	1.1	2.0	2.4	1.4	0.6	-0.0	2.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.6	0.1	0.2	-1.9	-0.1	-0.2	0.0	0.5	-0.4	-0.8	-1.2	0.3	0.7	-1.0
Leg predicted mass (left)	0.4	1.9	13.7	0.7	1.1	-0.9	0.4	0.2	0.3	1.6	-0.5	-1.3	-0.1	1.9	3.7	-0.7
Past tobacco smoking	0.4	0.7	1.4	1.0	0.8	0.5	1.1	1.1	0.6	0.8	0.6	0.8	0.7	0.5	1.2	1.1
Forced vital capacity (FVC)	0.4	1.5	6.6	1.2	0.8	-1.7	0.3	0.1	1.2	1.1	-0.3	-1.1	-0.7	1.8	2.6	-0.8
Mouth/teeth dental problems	0.4	0.5	1.1	-0.9	-0.6	-0.2	-0.9	-1.1	-0.6	-0.5	-0.8	-0.9	-0.5	-1.0	0.6	-0.4
Fluid intelligence score	0.4	0.7	2.7	1.0	0.7	-0.4	0.5	0.5	0.9	0.9	0.5	0.3	-0.0	1.6	1.6	0.4
Noisy workplace	0.4	0.5	2.0	0.5	0.5	1.4	0.4	0.5	-0.2	0.5	1.0	0.7	1.0	0.0	-0.5	0.7
Medication: Lansoprazole	0.4	0.5	1.3	1.1	0.6	-0.6	0.3	0.3	0.8	0.9	0.7	0.4	-0.2	0.8	1.1	0.4
Prospective memory result	0.4	0.5	1.9	-0.9	-1.0	-0.0	-0.7	-0.5	0.7	-1.4	-0.7	-0.6	-0.4	-0.1	-0.7	-0.2
Birth weight of first child	0.4	0.8	2.2	-0.4	-0.7	-1.4	-0.6	-0.5	0.5	-0.5	-0.8	-1.4	-1.5	0.8	0.3	-0.8
Medication: Blood pressure	0.4	0.7	1.5	-1.1	-1.1	-0.5	-0.8	-0.8	-0.8	-1.2	-1.0	-0.7	-0.8	-0.7	-0.8	-0.7
Medication: Omeprazole	0.4	0.5	1.2	-1.0	-0.7	-0.2	-0.9	-0.9	-1.1	-0.6	-0.7	-0.6	-0.3	-0.9	-0.2	-0.6
Suffer from ‘nerves’	0.4	0.7	1.6	-0.5	-0.6	-1.0	-0.8	-0.8	0.1	-0.5	-0.7	-1.2	-1.2	1.0	0.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.6	0.8	0.6	0.6	0.5	0.5	0.8	1.0	0.8	0.6	1.0	0.5	0.5
Breast cancer (self-reported)	0.4	0.5	1.7	-0.5	-0.2	1.0	0.2	0.3	0.4	-0.6	0.6	1.0	0.8	-0.5	-1.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	3.4	0.9	1.3	-0.8	0.6	0.4	0.3	1.3	0.5	0.2	-0.1	0.5	1.9	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	2.1	-0.8	-1.3	-0.4	-0.9	-0.8	0.2	-1.5	-0.9	-0.7	-0.9	-0.6	-1.1	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.8	-1.3	-0.1	0.9	0.4	0.4	-1.3	-0.3	-0.1	0.0	0.3	-0.4	-0.8	-0.4
High cholesterol (Self-reported)	0.4	0.8	1.3	-0.4	-1.0	-1.1	-1.0	-1.0	-0.7	-0.8	-1.1	-0.9	-1.1	-0.6	0.6	-0.6
Medication: Paracetamol	0.4	0.6	1.1	1.0	0.7	-0.4	0.8	0.9	0.7	0.5	0.9	0.9	-0.1	1.0	0.1	0.8
Alcohol drinker status: Never	0.4	0.5	1.5	1.2	-0.0	0.5	-0.2	-0.1	1.0	0.2	1.2	0.7	0.6	0.9	-0.3	0.8
Irritability	0.4	0.6	2.4	0.5	0.6	-0.9	0.4	0.4	1.5	0.5	0.2	0.1	-0.4	1.3	1.2	0.3
Risk taking	0.4	0.6	3.0	1.0	0.5	-0.3	0.3	0.3	0.8	0.8	0.4	-0.2	-0.0	1.3	1.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.6	-0.7	-0.4	-0.7	-0.8	-0.8	-0.7	-0.3	-0.8	-0.7	-0.6	-0.8	0.2	-0.7
Impedance of whole body	0.4	1.9	5.4	-2.0	-1.7	0.1	-1.3	-1.2	-1.1	-2.0	-0.9	-0.5	-0.9	-1.4	-2.3	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	1.2	1.2	-0.4	1.0	0.9	1.0	1.2	0.6	0.6	0.1	1.3	1.8	0.6
Neuroticism (Nagel 2018)	0.3	0.6	1.3	-0.5	-1.0	-0.9	-1.1	-1.0	0.3	-0.7	-0.6	-0.9	-0.9	0.4	0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	0.6	1.0	0.4	0.6	0.5	0.9	1.0	0.8	0.4	0.4	1.3	1.3	0.6
Mean Putamen Volume	0.3	0.4	1.3	0.7	0.5	0.3	0.4	0.3	1.1	0.4	0.5	0.1	0.5	1.1	0.2	0.9
HDL Cholesterol	0.3	0.5	1.6	0.1	0.0	1.1	0.1	0.2	-0.3	-0.0	0.5	1.0	1.1	-1.2	-0.3	1.3
Neuroticism (2016)	0.3	0.4	1.7	0.3	-0.1	1.3	-0.4	0.0	0.1	0.0	1.1	0.5	0.9	0.5	-0.9	0.5
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.3	-0.8	-0.9	-0.6	-0.6	0.7	-0.8	-0.6	-0.4	-1.0	-0.0	0.3	-0.3
Height	0.3	5.0	18.7	-1.5	0.3	-3.0	-0.8	-1.1	0.2	0.8	-2.1	-3.5	-2.3	2.1	4.3	-2.2
Type 2 Diabetes (T2D) (2018)	0.3	0.7	2.7	0.7	0.9	-0.1	0.4	0.4	1.6	0.9	0.7	0.3	0.2	1.3	1.0	0.5
Number of treatments/medications taken	0.3	0.6	1.6	-0.5	-1.2	-0.3	-1.2	-1.0	-0.3	-1.2	-0.7	-0.6	-0.6	-0.3	-0.6	-0.3
Systolic blood pressure, automated reading	0.3	0.8	1.8	0.5	0.6	1.4	1.0	1.0	0.9	0.4	0.7	1.1	1.2	0.9	-0.2	0.9
Angina	0.3	0.5	1.8	0.1	0.1	0.6	-0.1	-0.1	-0.9	0.0	0.3	0.6	0.7	-1.3	-1.3	0.4
Medication for hormone replacement therapy	0.3	0.3	0.6	0.8	0.6	0.3	0.7	0.7	0.6	0.5	0.4	0.4	0.6	0.5	0.3	0.4
Severe depression (siblings)	0.3	0.3	1.6	0.4	0.1	-0.6	-0.1	-0.2	0.3	0.4	-0.6	-1.1	-0.3	0.5	1.2	-0.2
Impedance of leg (right)	0.3	1.5	3.7	-1.5	-1.7	-0.8	-1.4	-1.3	0.1	-1.9	-1.0	-0.8	-1.5	-0.6	-1.5	-0.5
Leg fat-free mass (left)	0.3	1.8	13.4	0.6	1.0	-0.9	0.3	0.1	0.2	1.5	-0.5	-1.3	-0.1	1.8	3.7	-0.7
Fed-up feelings	0.3	0.5	1.9	-0.6	-0.6	-1.4	-0.6	-0.6	-0.4	-0.5	-0.9	-0.5	-0.7	-1.2	-0.1	-0.3
Supplements: Glucosamine	0.3	0.4	1.2	0.3	0.3	1.1	0.3	0.3	-0.2	0.4	0.8	0.9	1.0	-0.0	0.3	0.6
High blood pressure (mother)	0.3	0.5	2.6	0.1	-0.5	-1.6	-0.3	-0.3	0.2	-0.4	-0.8	-0.7	-1.1	0.1	0.2	-0.8
Financial difficulties in last 2 years	0.3	0.4	3.1	-0.1	0.1	-0.9	-0.1	-0.2	-0.3	0.4	-0.7	-0.7	-0.4	0.5	1.8	0.1
Pain all over the body in last month	0.3	0.3	0.7	-0.2	-0.7	-0.5	-0.8	-0.7	-0.2	-0.7	-0.6	-0.3	-0.6	-0.8	-0.1	-0.0
Weight	0.3	1.4	9.7	0.4	0.9	-0.8	0.2	-0.0	0.2	1.3	-0.4	-1.2	-0.2	1.7	3.1	-0.7
Worrier / anxious feelings	0.3	0.6	2.6	0.7	0.2	0.1	0.1	0.0	1.6	0.4	0.2	-0.2	0.4	1.2	1.6	0.7
Happiness	0.3	0.3	2.1	-0.3	0.3	-0.2	0.1	0.0	-1.4	0.4	-0.3	-0.2	0.0	-1.2	-0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	-1.0	-0.2	-0.9	-0.2	-0.1	-0.5	-0.3	-0.4	-0.5	-1.1	0.2	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.8	0.6	0.8	-1.6	0.1	-0.1	0.1	1.0	-0.4	-1.2	-1.0	1.2	2.0	-1.1
Standing height	0.3	3.1	17.0	0.0	1.3	-1.6	0.3	0.1	0.7	1.6	-0.8	-2.1	-1.1	2.8	4.1	-1.3
Exposure to tobacco smoke at home	0.3	0.3	1.5	-0.1	-0.1	1.2	0.3	0.4	-1.0	-0.1	0.4	0.6	0.7	-0.6	0.0	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.6	-0.2	-0.8	-0.5	-0.6	-0.8	-0.1	-0.7	-1.1	-0.4	-0.2	-0.2	-0.9
Loud music exposure frequency	0.3	0.4	1.0	-0.6	-0.3	-1.0	-0.4	-0.5	-0.8	-0.1	-0.6	-0.9	-0.8	-0.1	-0.1	-0.8
Blood clot in the leg (DVT)	0.3	0.4	1.2	0.8	0.9	-0.6	0.5	0.4	0.1	1.1	0.1	-0.2	-0.0	0.1	1.1	-0.0
Medication: Paracetamol	0.3	0.6	1.0	1.0	0.9	-0.7	0.9	0.9	0.5	0.9	0.9	0.7	-0.2	0.8	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.1	-0.9	-0.3	-0.8	-0.5	0.7	-1.1	-0.4	0.2	-0.3	-1.0	-1.0	0.2
Forced vital capacity (FVC), Best measure	0.3	1.2	4.8	0.8	1.1	-1.6	0.4	0.2	0.2	1.3	-0.4	-1.1	-0.9	1.2	2.2	-1.0
Angina (self-reported)	0.3	0.4	1.6	0.1	-0.0	0.6	-0.2	-0.2	-0.7	0.0	0.3	0.6	0.7	-1.2	-1.1	0.4
Number of full sisters	0.3	0.4	0.9	-0.2	-0.4	-0.7	-0.7	-0.9	-0.4	-0.3	-0.8	-0.9	-0.2	-0.9	-0.5	-0.8
Supplements: Vitamin C	0.3	0.4	0.8	-0.0	-0.9	-0.6	-0.9	-0.8	-0.0	-0.9	-0.5	-0.1	-0.6	-0.6	-0.3	-0.2
Leg fat-free mass (right)	0.3	1.8	11.8	0.8	1.4	-0.5	0.7	0.5	0.2	1.8	-0.1	-0.9	0.3	1.9	3.4	-0.5
Ever had bowel cancer screening	0.3	0.3	0.6	-0.3	0.8	0.8	0.7	0.8	-0.7	0.6	0.5	0.2	0.4	0.3	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.9	-0.3	0.8	0.3	0.8	0.7	-1.4	0.8	0.1	0.1	0.3	-0.2	0.3	0.1
Mineral and other dietary supplements	0.3	0.4	0.8	0.5	0.8	0.4	0.8	0.9	0.6	0.7	0.5	0.1	0.2	0.9	0.3	0.3
Leg predicted mass (right)	0.3	1.7	11.0	0.8	1.3	-0.5	0.6	0.4	0.2	1.7	-0.1	-0.9	0.2	1.8	3.3	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	2.6	0.4	0.3	-0.2	-0.1	-0.1	0.4	0.4	-0.0	-0.4	-0.0	1.5	1.6	0.1
Wears glasses or contact lenses	0.3	0.4	1.3	0.7	0.6	0.5	0.8	0.7	0.1	0.7	0.5	0.7	1.1	-0.0	0.0	0.4
Ever taken oral contraceptive pill	0.3	0.4	1.4	0.4	0.3	-1.0	0.2	0.1	1.2	0.2	-0.3	-0.2	-0.6	0.7	0.9	0.4
Mother’s age at death	0.3	0.3	0.9	0.0	0.9	-0.5	0.7	0.6	0.4	0.7	-0.0	-0.1	-0.5	0.8	1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.2	-0.3	-0.1	-1.5	-0.1	-0.2	-0.3	-0.1	-0.6	-0.3	-0.8	-0.7	-0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.4	1.0	0.3	-0.8	0.0	-0.1	0.5	0.6	0.2	0.2	0.1	0.5	1.2	0.3
Medication: Lisinopril	0.3	0.4	2.0	-0.7	-0.3	1.4	-0.1	-0.0	-1.0	-0.3	0.2	0.4	0.8	-0.5	-0.6	0.1
Ever smoked	0.3	0.5	1.9	-0.8	-0.8	0.1	-0.9	-0.9	0.2	-0.8	-0.4	-0.5	-0.1	-0.3	-1.4	-0.8
Average weekly beer plus cider intake	0.3	0.5	1.4	0.9	-0.2	1.1	-0.1	0.0	0.9	-0.2	0.7	0.8	1.2	0.3	0.1	0.9
Age started oral contraceptive pill	0.3	0.4	1.0	-0.2	-0.4	-1.0	-0.6	-0.7	0.1	-0.2	-0.6	-0.8	-0.8	-0.6	-0.1	-0.7
Cholesterol lowering medication	0.3	0.4	1.5	0.2	0.2	1.2	0.3	0.4	-0.6	0.2	0.5	0.9	1.0	-0.8	-0.7	0.6
Pain experienced in last month	0.3	0.5	2.2	-0.7	-0.7	-0.3	-0.6	-0.5	-0.3	-0.7	-0.6	-1.0	-0.8	0.3	-0.2	-1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-0.5	-0.3	-1.0	-0.6	-0.8	-0.6	-0.3	-0.6	-0.4	-0.4	-1.1	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.2	0.8	0.9	-0.4	0.6	0.4	0.1	1.1	0.2	-0.1	0.1	0.1	1.0	0.1
Worry (Nagel 2018)	0.2	0.4	1.0	-0.9	-0.9	0.0	-1.0	-0.9	0.2	-0.8	-0.4	-0.7	-0.5	0.1	-0.3	-0.2
Age at First Birth	0.2	0.2	1.0	0.6	0.5	0.2	0.6	0.6	-0.1	0.6	0.3	0.3	0.2	0.3	1.0	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.8	-0.6	-0.4	-0.5	-0.4	-0.3	-0.7	-0.9	-0.4	-0.4	-0.9	-0.0	-0.1
Heel T-Score	0.2	1.3	2.8	0.5	1.2	0.7	1.6	1.7	1.7	0.7	1.2	1.6	0.8	0.5	-0.2	1.3
Smoking Status	0.2	0.4	0.7	-0.4	-0.8	-0.6	-0.8	-0.7	-0.1	-0.8	-0.6	-0.5	-0.7	-0.7	-0.5	-0.5
Hypothyroidism (self reported)	0.2	0.4	2.9	0.2	0.3	1.7	0.3	0.3	-0.9	0.3	0.7	0.3	0.8	0.3	-0.3	0.4
Respiratory disease	0.2	0.3	1.2	0.6	-0.2	1.0	-0.1	-0.0	0.9	-0.1	0.4	0.3	0.8	-0.0	-0.2	1.1
Lung FVC	0.2	0.8	2.0	1.1	1.4	-0.8	1.2	0.9	0.1	1.4	0.4	0.0	-0.0	0.6	1.1	-0.3
Diabetes (father)	0.2	0.3	0.9	0.2	-0.5	0.7	-0.4	-0.3	0.3	-0.4	0.4	0.6	0.4	-0.6	-1.0	0.7
Pack years adult smoking proportion	0.2	0.3	1.0	0.1	-0.3	1.0	0.3	0.4	0.6	-0.4	0.3	0.6	0.6	-0.3	-0.0	0.8
Age when periods started (menarche)	0.2	0.5	2.0	0.1	0.8	-0.9	0.5	0.3	-0.5	1.1	-0.3	-0.9	-0.6	0.3	1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	0.5	0.6	0.5	0.8	0.8	0.5	0.6	0.6	0.2	0.1	1.3	0.8	0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.7	-0.2	-0.4	0.5	-0.4	-0.3	-0.7	-0.6	-0.3	0.0	0.2	-0.7	-1.3	0.0
Medication: Levothyroxine sodium	0.2	0.4	1.9	0.3	0.3	1.4	0.3	0.4	-0.4	0.5	0.5	0.3	0.8	0.4	0.7	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	-0.2	-0.6	0.1	-0.4	-0.4	-0.0	-0.6	-0.1	0.0	0.2	-0.5	-1.0	0.3
Impedance of leg (left)	0.2	0.9	4.1	-1.1	-1.2	-0.2	-0.9	-0.8	0.0	-1.5	-0.4	-0.2	-0.9	-0.5	-2.0	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	1.5	-0.4	0.2	-0.1	-0.2	-0.2	0.9	0.1	-0.3	-0.8	-0.3	1.2	0.6	-0.4
Medication: Ramipril	0.2	0.2	0.8	-0.5	0.1	-0.1	-0.1	-0.2	-0.9	0.1	-0.4	-0.7	-0.3	0.6	0.1	-0.8
Medication: Simvastatin	0.2	0.2	0.8	0.5	0.4	-0.5	0.2	0.2	0.4	0.4	-0.1	-0.4	-0.3	0.8	0.9	-0.4
Illnesses of siblings	0.2	0.2	0.9	-0.6	-0.4	0.0	-0.3	-0.3	-0.4	-0.6	-0.4	-0.0	-0.1	-1.0	-0.7	-0.2
Hip circumference	0.2	0.8	5.0	0.2	1.1	0.0	0.7	0.4	0.1	1.4	0.1	-0.4	0.4	1.3	2.2	0.0
Time employed in main current job	0.2	0.2	0.9	-0.0	-0.5	0.1	-0.6	-0.5	0.2	-0.5	-0.0	0.2	-0.0	-1.0	-0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.3	0.3	-0.2	-1.1	-0.4	-0.3	0.7	-0.2	-0.5	-0.2	-0.7	-0.5	0.1	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	1.8	0.2	0.1	0.3	0.4	0.4	-0.6	0.0	0.4	0.6	0.5	-0.4	-1.3	0.2
Worry too long after embarrassment	0.2	0.4	3.2	0.6	0.2	-0.2	0.4	0.4	0.6	0.4	0.4	-0.2	-0.2	1.8	0.7	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.8	1.0	0.1	0.4	0.0	0.2	1.3	0.1	0.6	0.7	0.5	0.0	-0.0	1.2
Eye problems/disorders: None of the above	0.2	0.2	1.5	0.6	0.3	0.4	-0.0	-0.1	0.1	0.5	0.3	-0.2	0.1	0.6	1.2	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.3	-0.4	0.3	-0.8	-0.7	0.7	-0.3	-0.2	-0.4	0.0	0.1	0.3	0.2
Medication: Ibuprofen	0.2	0.2	0.6	-0.7	-0.3	-0.3	-0.3	-0.2	-0.7	-0.4	-0.1	-0.1	-0.6	0.2	0.4	-0.7
Heart disease (mother)	0.2	0.2	0.7	-0.8	-0.4	-0.1	-0.5	-0.5	-0.7	-0.3	-0.5	-0.6	-0.2	-0.3	0.3	-0.6
Whole body fat mass	0.2	0.7	5.0	-0.1	0.4	-0.4	0.1	-0.2	-0.4	0.8	-0.5	-1.0	-0.2	1.1	2.2	-0.5
Leg fat mass (right)	0.2	0.6	4.0	-0.1	0.0	-0.8	-0.3	-0.5	-0.0	0.4	-0.7	-1.1	-0.4	0.8	2.0	-0.5
Comparative height size at age 10	0.2	1.4	3.6	-1.8	-0.3	-0.8	-0.6	-0.6	-1.2	-0.3	-1.3	-1.9	-1.3	0.7	0.7	-1.9
Overall health rating	0.2	0.4	2.1	0.8	-0.0	-0.8	-0.5	-0.6	0.6	0.3	-0.3	-0.8	-0.3	0.7	1.4	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.2	-0.2	0.0	1.1	0.2	0.3	0.4	-0.2	0.2	0.4	1.0	-0.4	-0.1	0.8
Hypertension (Self-reported)	0.2	0.5	2.7	-0.4	-0.4	1.0	-0.1	0.0	-0.2	-0.6	0.2	0.9	0.6	-0.7	-1.6	0.6
Average weekly red wine intake	0.2	0.2	0.7	-0.5	0.4	0.5	0.8	0.8	-0.3	0.3	0.3	0.2	0.0	0.8	-0.1	-0.4
Guilty feelings	0.2	0.2	0.6	-0.5	-0.5	-0.7	-0.2	-0.1	0.7	-0.5	-0.2	-0.3	-0.6	0.8	-0.6	-0.2
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.2	-0.3	-0.4	-0.7	-0.7	-0.9	0.0	-0.2	-0.4	-0.2	-0.0	-0.1	-0.4
Medication: Blood pressure	0.2	0.3	0.7	0.5	0.6	0.5	0.6	0.6	0.1	0.5	0.6	0.7	0.7	0.5	-0.8	0.3
Number of operations (self-reported)	0.2	0.3	0.6	-0.5	-0.7	-0.4	-0.7	-0.8	-0.5	-0.6	-0.6	-0.6	-0.2	-0.6	-0.4	-0.6
Unable to work because of sickness or disability	0.2	0.2	1.1	-0.0	-0.5	-0.3	-0.6	-0.5	-0.0	-0.5	-0.3	-0.2	-0.4	-1.1	-0.6	0.3
Supplements: Calcium	0.2	0.2	0.6	0.3	-0.5	0.2	-0.7	-0.6	0.1	-0.4	0.1	0.2	0.2	-0.7	-0.8	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.8	-0.1	-0.4	-0.1	-0.0	-0.7	-0.2	-0.4	0.1	-0.7	-1.1	-0.2	-0.5
Major Depression (MDD)	0.1	0.1	0.5	0.1	0.2	0.2	0.2	0.1	0.4	0.4	-0.1	-0.5	0.2	0.2	0.7	0.3
Bipolar Disorder (2011)	0.1	0.1	0.5	0.0	0.0	0.7	-0.0	0.1	0.6	-0.0	0.2	-0.0	0.5	0.3	0.1	0.2
LDL Cholesterol	0.1	0.2	0.7	-0.4	-0.4	-0.1	-0.3	-0.2	-0.7	-0.3	0.2	0.2	-0.4	-0.6	-0.8	-0.4
BMI	0.1	0.4	1.2	0.7	0.6	0.2	0.6	0.4	-0.1	1.0	0.3	0.0	0.7	0.7	1.1	0.1
Waist Hip Ratio (WHR)	0.1	0.6	2.7	0.3	-0.5	1.6	-0.0	0.3	-0.3	-0.6	0.7	1.1	0.9	-0.4	-0.6	0.9
Cardiovascular Disease	0.1	0.3	1.2	-0.1	-1.0	0.2	-0.7	-0.5	0.4	-1.1	-0.2	0.3	-0.0	-0.4	-0.9	0.5
Lung FEV1/FVC ratio	0.1	0.6	2.2	0.3	0.8	1.0	0.4	0.2	0.2	1.1	0.9	0.0	0.8	1.5	1.0	0.2
Neuroticism	0.1	0.3	0.9	-0.3	-0.5	-0.9	-0.6	-0.7	-0.1	-0.3	-0.6	-0.7	-0.6	-0.1	0.1	-0.5
Ever had hysterectomy (womb removed)	0.1	0.2	0.6	0.3	-0.3	-0.8	-0.4	-0.5	0.1	-0.1	-0.3	-0.4	-0.4	-0.1	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.1	-0.1	-0.6	-0.2	-0.2	0.1	-0.1	0.1	-0.2	-0.7	0.7	0.1	-0.2
Vitamin and mineral supplements	0.1	0.1	0.3	-0.4	0.4	0.2	0.2	0.1	-0.1	0.3	0.0	-0.4	0.2	0.6	0.2	-0.2
Trunk fat percentage	0.1	0.4	1.6	-0.9	-0.3	-0.2	-0.5	-0.6	-1.3	-0.1	-0.7	-0.9	-0.3	-0.2	1.0	-0.5
Current tobacco smoking	0.1	0.2	0.8	0.1	-0.0	0.5	0.4	0.5	-0.3	-0.1	0.0	0.5	0.4	-0.9	-0.7	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.8	-0.2	0.2	-0.1	0.3	0.3	-0.5	0.1	-0.4	0.2	0.1	-0.9	0.3	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.4	-0.2	-0.4	-0.3	-0.3	0.5	-0.2	0.4	0.1	-0.4	-0.3	-0.5	0.1
High blood pressure	0.1	0.3	1.8	-0.5	-0.6	0.3	-0.5	-0.4	-0.2	-0.8	-0.3	0.3	0.1	-0.4	-1.3	0.2
Body mass index (BMI)	0.1	0.2	2.0	0.4	0.3	-0.2	0.1	-0.1	-0.2	0.6	-0.1	-0.3	0.3	0.4	1.4	-0.1
Trunk fat mass	0.1	0.5	4.2	-0.3	0.4	-0.3	0.0	-0.2	-0.6	0.7	-0.4	-0.9	-0.1	0.8	2.1	-0.5
Waist circumference	0.1	0.3	2.1	0.2	0.5	0.5	0.4	0.3	-0.4	0.8	0.3	-0.1	0.4	0.7	1.4	0.1
Alcohol usually taken with meals	0.1	0.1	0.4	-0.6	-0.1	-0.2	0.3	0.3	0.3	-0.3	-0.3	-0.1	-0.4	0.5	-0.3	-0.3
Nervous feelings	0.1	0.1	1.3	-0.3	-0.2	0.2	-0.2	-0.1	0.4	-0.3	0.2	0.1	-0.2	0.2	-1.1	0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.5	-0.5	0.6	-0.5	-0.5	-0.6	-0.4	-0.2	-0.1	0.1	-0.3	-0.1	0.2
Had other major operations	0.1	0.2	0.7	0.5	-0.2	-0.3	-0.4	-0.5	0.9	-0.1	0.3	0.1	-0.1	-0.3	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.2	0.1	0.8	0.5	0.6	0.5	-0.0	0.4	0.3	0.3	0.8	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.3	0.5	0.7	0.3	0.3	0.1	0.5	0.5	0.3	0.6	-0.1	-0.4	0.3
Neuroticism score	0.1	0.2	0.7	-0.3	-0.4	-0.9	-0.4	-0.4	0.1	-0.2	-0.5	-0.6	-0.7	0.1	0.2	-0.4
Arm fat percentage (right)	0.1	0.4	1.7	-0.8	-0.5	0.0	-0.7	-0.8	-1.3	-0.3	-0.6	-0.7	-0.1	-0.1	0.5	-0.6
Father’s age at death	0.1	0.2	0.8	0.0	-0.2	-0.1	-0.5	-0.5	-0.4	-0.1	-0.6	-0.4	-0.1	-0.9	0.8	-0.1
Falls in the last year	0.1	0.1	0.4	0.2	-0.1	-0.4	-0.3	-0.2	0.5	-0.1	-0.0	-0.1	-0.5	0.7	0.2	0.1
Asthma	0.1	0.3	2.1	0.6	-0.3	0.0	-0.2	-0.1	1.4	-0.3	0.1	-0.2	-0.2	0.7	-0.1	0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.0	-0.3	-0.4	-0.3	-0.2	0.3	-0.4	-0.2	0.0	-0.0	-0.4	-0.1	-0.1
Arm fat mass (right)	0.1	0.6	3.5	-0.2	0.1	-0.6	-0.3	-0.5	-0.6	0.5	-0.6	-1.0	-0.3	0.7	1.9	-0.8
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	-0.3	-0.5	-0.5	-0.4	-0.5	-0.3	-0.2	-0.3	-0.6	-0.4	-0.2	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	0.1	-0.1	0.9	-0.0	-0.0	-1.0	0.1	0.3	0.2	0.4	-0.1	-0.3	0.1
Body fat percentage	0.1	0.2	1.1	-0.5	-0.1	-0.1	-0.2	-0.4	-0.9	0.1	-0.4	-0.6	-0.1	0.2	1.0	-0.3
Leg fat percentage (right)	0.1	0.2	0.5	-0.4	-0.4	-0.3	-0.6	-0.7	-0.2	-0.3	-0.4	-0.6	-0.3	0.4	0.6	-0.4
Comparative body size at age 10	0.1	0.4	0.7	-0.4	-0.7	-0.8	-0.6	-0.5	0.8	-0.8	-0.6	-0.7	-0.5	0.7	-0.0	-0.6
Number of full brothers	0.1	0.1	0.3	0.6	0.4	-0.6	-0.1	-0.2	-0.4	0.5	0.3	-0.2	-0.4	0.2	0.1	-0.3
Age at first live birth	0.1	0.2	0.8	0.6	0.1	0.6	0.5	0.6	0.5	0.1	0.4	0.2	0.2	0.9	-0.0	0.3
Pulse wave peak to peak time	0.1	0.1	0.2	-0.2	0.3	0.1	0.2	0.1	-0.5	0.3	0.0	-0.2	-0.2	0.4	0.2	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	0.3	-0.1	1.0	0.0	-0.0	0.7	-0.1	0.2	0.2	0.8	0.2	-0.3	0.6
Age at last live birth	0.1	0.1	0.7	0.1	0.2	0.2	0.3	0.3	0.3	0.2	0.1	-0.1	-0.1	0.8	0.7	0.2
Knee pain experienced in last month	0.1	0.1	0.4	0.4	-0.0	-0.5	0.0	0.0	0.2	0.1	-0.3	-0.4	-0.1	0.4	0.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.0	0.1	0.5	0.0	0.0	-0.4	0.2	0.4	0.5	0.5	-0.5	-0.4	0.6
Arm fat percentage (left)	0.1	0.2	1.2	-0.6	-0.4	0.2	-0.4	-0.5	-1.1	-0.1	-0.4	-0.4	0.2	-0.2	0.6	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.1	0.4	-0.4	-0.0	-0.1	0.4	0.4	0.0	-0.2	-0.3	0.5	0.5	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.9	-0.2	0.1	0.0	0.0	0.1	-0.0	0.2	0.4	-0.2	-0.3	0.9	0.2	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.8	-0.0	-0.2	-0.9	-0.0	-0.1	0.5	-0.3	-0.4	-0.3	-0.6	0.1	-0.3	-0.4
Asthma (self-reported)	0.1	0.2	1.6	0.6	-0.2	0.3	-0.1	0.0	1.3	-0.2	0.2	-0.1	0.1	0.5	-0.1	0.5
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.0	0.1	-0.2	-0.4	-0.4	-0.2	-0.3	-0.4	-0.6	-0.5
Smoking status: Current	0.1	0.1	0.4	0.3	0.2	0.5	0.6	0.7	-0.1	0.1	0.2	0.4	0.4	-0.4	-0.2	0.2
Arm fat mass (left)	0.1	0.5	3.7	-0.1	0.1	-0.6	-0.2	-0.4	-0.5	0.5	-0.6	-0.9	-0.1	0.7	1.9	-0.6
Financial situation satisfaction	0.1	0.1	0.5	-0.4	0.0	-0.7	-0.2	-0.3	-0.4	0.1	-0.2	-0.3	-0.6	-0.2	0.2	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.1	-0.2	-0.7	0.1	0.2	0.2	-0.4	0.0	0.2	-0.5	0.7	-0.8	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.6	0.1	-0.2	-0.0	-0.0	0.2	-0.2	-0.1	0.0	-0.2	0.5	-0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.4	0.4	0.7	0.1	0.6	0.5	0.2	0.8	0.3	-0.1	0.1	0.4	1.2	-0.1
Heart disease (siblings)	0.1	0.1	0.5	-0.2	-0.3	-0.3	-0.1	-0.0	0.0	-0.3	-0.2	-0.3	-0.2	-0.2	-0.7	-0.2
Pack years of smoking	0.1	0.1	0.5	-0.3	-0.4	0.7	0.1	0.2	0.3	-0.6	-0.0	0.2	0.3	-0.3	-0.0	0.4
Leg fat mass (left)	0.1	0.4	3.0	-0.1	0.1	-0.5	-0.2	-0.4	-0.1	0.4	-0.5	-0.9	-0.1	0.8	1.7	-0.5
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.2	0.1	0.2	0.2	0.2	-0.1	0.2	-0.0	-0.2	-0.0	0.1	0.2	-0.2
Hair Pigment	0.0	0.1	0.3	-0.2	-0.3	-0.3	0.0	0.1	-0.1	-0.5	-0.1	0.3	-0.6	0.1	-0.4	0.4
Tanning	0.0	0.1	0.4	0.4	0.4	-0.4	0.6	0.6	0.6	-0.0	-0.2	0.3	0.0	-0.4	-0.0	0.2
Relative age of first facial hair	0.0	0.1	0.3	0.5	0.1	-0.5	-0.2	-0.2	0.5	0.1	-0.3	-0.1	0.2	-0.1	0.3	0.3
Diabetes (self-reported)	0.0	0.1	0.1	-0.1	0.3	-0.2	-0.2	-0.3	-0.1	0.3	0.2	-0.1	-0.3	-0.1	0.3	-0.3
Glaucoma (self-reported)	0.0	0.1	0.2	-0.5	-0.1	0.4	0.2	0.3	-0.2	-0.2	-0.1	0.0	0.1	0.0	-0.2	-0.1
Alcohol intake frequency.	0.0	0.1	0.7	0.0	0.1	0.0	-0.1	0.0	0.3	0.3	0.4	0.1	0.0	0.3	0.8	0.5
Mood swings	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1	-0.1	-0.1	-0.0	0.1	0.1	0.1	-0.1	0.3	0.1
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.3	0.1	0.3	0.4	0.4	0.1	-0.1	-0.2	0.1	-0.1	-0.1	-0.1	0.4
Leg fat percentage (left)	0.0	0.1	0.2	-0.4	-0.3	0.1	-0.3	-0.4	-0.4	-0.2	-0.1	-0.2	0.0	0.2	0.1	-0.2

Hub : Genes

CCDC114

Models

Trait associations