Hub : Genes

CCDC12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0580	0.0240	3.3e-04	0.074	NA	0.029	NA	0.060	9.3e-07	NA	1.7e-03	NA	1.1e-05
2	METSIM	Adipose	0.0803	0.0257	1.6e-11	0.063	0.073	0.099	0.073	0.102	1.0e-09	4.3e-11	1.2e-14	4.8e-11	5.2e-15
3	YFS	Blood	0.1057	0.0258	0.0e+00	0.080	0.083	0.101	0.098	0.103	5.8e-25	8.3e-26	3.1e-31	2.9e-30	6.3e-32
4	TCGA	Breast Invasive Carcinoma	0.0172	0.0104	5.4e-04	0.009	0.012	0.004	NA	0.008	4.2e-03	1.6e-03	3.5e-02	NA	8.6e-03
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.0490	0.0270	5.0e-04	0.019	0.026	0.011	NA	0.010	1.8e-02	6.5e-03	6.0e-02	NA	6.4e-02
6	TCGA	Prostate Adenocarcinoma	0.0335	0.0253	9.1e-03	0.001	0.006	0.006	NA	0.001	2.4e-01	6.4e-02	6.3e-02	NA	2.3e-01
7	TCGA	Stomach Adenocarcinoma	0.0540	0.0350	1.2e-03	0.017	0.033	0.029	NA	0.021	2.0e-02	2.0e-03	3.3e-03	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.6	2.6	4.4	-2.1	-0.7	0.1	1.8	1.6	1.9	1.9
Bipolar Disorder or Schizophrenia	0.7	1.6	3.5	-1.3	-0.7	-0.5	1.5	1.1	1.9	1.4
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	-1.1	-0.5	-1.0	0.8	0.8	1.2	0.8
Depression (Nagel 2018)	0.1	0.1	0.3	-0.2	-0.0	-0.1	0.3	0.1	0.6	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.2	-0.5	-1.8	-1.6	0.4	0.5	0.8	0.6
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.3	0.4	0.0	-0.1	-0.5	0.4	-0.1
Schizophrenia (2018)	0.1	0.2	0.8	0.0	-0.4	-0.6	0.4	0.1	0.9	0.3
Schizophrenia vs Biploar Disorder	1.5	2.0	3.3	1.6	0.7	-0.3	-1.4	-1.8	-1.6	-1.8
Worry (Nagel 2018)	0.1	0.2	0.6	-0.7	0.2	0.2	0.5	0.0	0.6	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.5	-0.5	-0.3	0.4	0.8	0.6	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.3	0.2	-0.4	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.1	-0.4	-0.4	0.2	0.8	0.5	0.1
Crohns Disease (2017)	0.5	1.2	4.0	-2.0	-1.0	-0.6	0.9	0.7	0.9	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	3.0	-1.7	-0.3	-0.0	-0.1	-0.4	-0.1	0.0
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.9	-0.0	0.1	-0.7	-0.9	-0.6	-0.4
Major Depression (MDD)	0.2	0.2	0.6	0.6	0.7	0.6	-0.1	-0.3	-0.3	-0.4
Reaction Time	9.0	17.2	22.4	4.4	3.8	2.8	-4.3	-4.7	-4.2	-4.4
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.9	-1.0	-2.2	-2.0	1.2	1.4	1.7	1.4
Breast Cancer	0.6	1.6	3.5	1.1	-1.2	-1.9	1.3	1.3	1.0	-0.0
Ovarian Cancer	2.4	3.2	5.1	2.3	2.0	1.7	-1.4	-1.7	-1.8	-1.5
Prostate Cancer	0.2	0.2	1.0	-0.1	-0.1	-0.3	0.6	0.2	1.0	0.4
Age at First Birth	1.4	2.0	3.7	1.9	0.9	0.9	-1.4	-1.0	-1.7	-1.7
Bipolar Disorder (2011)	1.2	1.1	7.1	-2.7	-0.9	-0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.6	-1.2	-0.2	-0.1	0.3	1.0	0.6	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.1	0.6	0.3	0.3	-1.0	-0.7	-1.1	-0.9
Crohns Disease (2012)	1.3	2.1	4.2	-2.1	-0.8	-0.2	1.4	1.5	1.8	1.4
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.5	0.6	-0.2	-0.1	-0.6	-0.5
Fasting Glucose	0.6	0.7	1.8	-0.6	-0.4	-0.3	0.9	1.3	0.7	0.9
HbA1C	1.7	1.9	2.6	1.5	1.1	0.8	-1.5	-1.3	-1.6	-1.6
HDL Cholesterol	3.1	5.2	6.2	-2.3	-2.3	-2.1	2.5	2.5	2.2	2.2
LDL Cholesterol	0.0	0.1	0.4	0.6	0.2	-0.0	0.0	0.3	0.1	-0.1
Lupus	0.7	1.1	2.3	1.5	0.8	0.4	-0.8	-0.6	-1.2	-1.4
Neuroticism (2016)	1.7	2.5	3.6	-1.4	-1.2	-1.0	1.7	1.8	1.7	1.9
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.3	0.2	0.2	-0.7	-0.4	-0.5	-0.5
Rheumatoid Arthritis	0.2	0.3	0.6	0.4	0.2	-0.1	-0.8	-0.6	-0.7	-0.6
Schizophrenia (2014)	0.0	0.0	0.1	0.2	-0.3	-0.4	0.2	0.0	0.2	-0.0
Triglycerides	1.9	3.2	4.1	2.0	1.8	1.3	-1.9	-1.8	-2.0	-1.6
Type 2 Diabetes (T2D) (2012)	7.8	9.0	13.8	2.6	2.9	2.6	-3.0	-3.7	-3.1	-2.9
Ulcerative Colitis	0.4	0.6	1.1	-0.0	0.8	0.9	-0.8	-1.1	-0.8	-0.7
Blood Eosinophil Count	1.1	8.5	10.9	2.5	2.9	2.7	-3.3	-3.2	-2.6	-3.1
Blood Platelet Count	0.3	3.4	11.3	-3.4	-1.0	-0.2	1.7	1.6	1.6	1.9
Blood Red Count	0.1	1.0	3.5	1.9	1.2	0.7	-0.2	0.6	-0.6	-0.8
Blood White Count	19.6	145.0	174.2	11.3	11.7	9.3	-12.7	-12.9	-13.2	-12.7
Heel T-Score	4.5	35.5	56.1	5.8	4.4	3.6	-6.7	-6.0	-7.5	-6.7
BMI	0.4	2.5	6.1	-2.5	-1.0	-1.4	1.2	1.6	1.5	1.4
Height	0.4	8.1	32.8	5.7	-0.1	-0.2	2.1	2.5	-3.1	-1.7
Waist Hip Ratio (WHR)	10.5	47.2	60.5	5.8	6.7	5.1	-7.8	-7.2	-7.3	-7.7
Systolic Blood Pressure	2.2	11.0	16.5	3.9	2.1	1.3	-3.1	-4.0	-3.6	-4.1
Smoking Status	2.6	6.2	8.1	-2.2	-2.5	-2.3	2.8	2.1	2.7	2.8
Allergy or Eczema	4.0	10.4	17.6	-3.1	-2.7	-1.9	3.5	3.6	4.2	3.0
Cardiovascular Disease	0.9	3.1	4.2	1.8	1.9	1.8	-1.4	-1.6	-2.1	-1.7
Hypothyroidism (self reported)	0.8	1.9	5.5	-1.3	-0.8	-1.3	1.3	1.0	2.4	1.1
Respiratory disease	0.2	0.5	1.8	-0.2	0.9	1.3	0.1	0.0	0.8	0.0
Type 2 Diabetes (T2D) (2018)	5.4	10.0	14.2	3.0	2.2	1.7	-3.6	-3.8	-3.8	-3.5
Lung FEV1/FVC ratio	1.5	7.4	12.8	3.3	1.4	0.2	-3.2	-2.8	-3.6	-2.8
Lung FVC	0.3	1.6	2.8	0.0	1.2	1.6	-1.6	-1.7	-1.1	-0.8
Neuroticism	0.5	1.2	2.5	-1.6	-0.2	-0.2	1.3	0.6	1.5	1.3
Chronotype (morning person)	1.6	3.7	5.3	1.4	2.2	2.0	-1.8	-2.1	-2.3	-1.7
Hair Pigment	0.1	3.9	7.9	-1.2	-2.5	-2.8	1.8	1.9	1.7	1.4
Tanning	0.1	1.1	2.3	0.3	1.5	0.9	-1.5	-1.2	-0.9	-0.5
Hand grip strength (left)	2.1	5.6	9.6	-1.2	-2.6	-2.2	3.1	3.1	1.3	2.3
Number of treatments/medications taken	0.3	0.6	1.6	-1.0	-0.0	0.1	0.8	0.7	1.3	0.7
Average weekly spirits intake	3.9	4.9	6.1	-1.9	-2.1	-2.5	2.1	2.5	2.3	2.1
Sensitivity / hurt feelings	0.2	0.4	1.5	-0.3	0.8	1.2	0.4	-0.1	0.5	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	0.4	0.3	0.1	-0.4	-0.9	-0.5	-0.5
Hearing difficulty/problems: Yes	1.9	2.9	4.1	1.6	1.6	1.1	-1.9	-2.0	-1.6	-2.0
Relative age of first facial hair	0.2	0.5	1.3	-0.1	0.6	1.1	0.8	0.1	0.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.1	-0.9	-0.7	-0.3	0.6	0.7	1.1	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.6	0.3	0.2	-0.4	-0.7	-0.2	-0.6
Ever had hysterectomy (womb removed)	1.0	1.1	2.4	-0.9	-1.0	-0.7	0.9	0.9	1.6	1.3
Systolic blood pressure, automated reading	0.5	1.4	2.7	1.6	0.9	0.4	-1.1	-1.2	-1.0	-1.7
Eye problems/disorders: Diabetes related eye disease	2.9	3.1	5.8	1.6	0.4	-0.1	-2.0	-2.4	-2.1	-2.2
Angina	1.4	1.8	3.4	1.3	1.1	0.9	-1.5	-1.0	-1.8	-1.4
Medication for hormone replacement therapy	0.2	0.3	0.6	0.4	0.4	0.0	-0.6	-0.6	-0.4	-0.7
Vitamin and mineral supplements	9.8	13.3	18.5	4.0	3.1	2.3	-4.2	-3.6	-4.3	-3.7
Supplements: Zinc	1.9	2.1	3.2	-1.5	-1.8	-1.6	1.4	1.3	1.4	1.1
Medication: Co-codamol	0.1	0.2	0.4	0.2	0.6	0.1	-0.6	-0.4	-0.3	-0.2
Medication: Metformin	3.2	4.5	6.8	1.8	1.6	1.0	-2.4	-2.5	-2.4	-2.6
Diabetes (father)	2.4	2.9	4.4	1.6	1.2	1.0	-1.7	-2.1	-1.9	-2.1
Diabetes (mother)	7.7	9.8	11.5	2.9	3.2	3.2	-2.8	-3.1	-3.4	-3.3
Severe depression (siblings)	0.5	0.5	1.2	-0.4	-0.6	-0.1	1.1	0.7	0.8	0.8
Pack years adult smoking proportion	1.5	2.3	4.8	1.7	2.2	1.9	-1.0	-1.0	-1.3	-1.0
Impedance of leg (right)	1.1	5.2	16.0	4.0	1.0	0.6	-1.7	-1.7	-2.6	-2.6
Leg fat-free mass (left)	0.2	1.3	3.8	-0.6	-0.7	-1.0	1.6	1.9	0.4	0.8
Trunk fat percentage	0.1	0.5	2.2	-0.4	-0.3	-0.8	0.6	1.5	0.4	0.4
Hand grip strength (right)	0.8	2.1	4.5	-0.3	-1.7	-1.7	2.1	1.8	0.2	1.2
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.4	0.1	0.3	-0.1	0.0	-0.2	0.3
Current tobacco smoking	0.2	0.3	0.6	0.8	0.0	-0.6	-0.2	-0.7	-0.4	-0.5
Average weekly fortified wine intake	2.3	2.6	4.9	-1.7	-2.2	-1.9	1.3	1.6	1.2	1.2
Maternal smoking around birth	3.6	5.2	8.8	3.0	1.8	1.0	-2.3	-2.5	-2.5	-2.4
Fed-up feelings	0.3	0.5	0.8	-0.6	0.9	0.6	0.8	0.5	0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	-0.7	-0.2	-0.1	0.9	0.7	1.1	0.8
Relative age voice broke	0.4	0.7	1.3	-0.9	-0.1	0.4	1.1	0.7	1.2	0.9
Taking other prescription medications	0.1	0.1	0.5	0.0	0.7	0.2	-0.3	-0.3	0.2	-0.5
Age when periods started (menarche)	0.4	1.1	2.0	-0.7	-0.9	-0.6	1.4	1.0	1.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.4	-0.2	-0.1	0.2	0.1	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.6	12.7	3.1	2.4	2.0	-2.8	-2.1	-3.6	-2.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.4	0.6	0.8	0.1	0.6	-0.0	0.3
Qualifications: CSEs or equivalent	2.8	3.7	5.3	1.9	1.8	1.5	-1.9	-2.3	-2.0	-2.0
Serious illness, injury or assault to yourself	0.6	0.8	1.4	-0.2	-1.1	-1.2	0.9	0.7	0.9	0.7
High blood pressure	0.0	0.1	0.2	-0.0	-0.1	-0.2	0.4	0.1	0.5	-0.1
Hayfever, allergic rhinitis or eczema	3.8	8.3	11.0	-2.6	-2.8	-2.2	3.3	3.2	3.3	2.6
Multivitamins +/- minerals	8.4	10.7	13.9	-3.6	-2.8	-2.1	3.7	3.4	3.7	3.3
Stomach or abdominal pain in last month	2.9	3.6	8.1	1.4	2.5	2.9	-1.6	-1.4	-1.4	-1.4
Supplements: Glucosamine	2.3	3.1	5.2	-1.1	-1.4	-1.1	2.3	2.3	1.9	1.8
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	2.5	1.5	1.6	1.2	-1.6	-1.4	-1.4	-1.3
Medication: Atenolol	0.6	0.8	2.1	-1.2	-1.1	-1.5	0.3	0.4	0.3	0.4
Medication: Levothyroxine sodium	1.6	2.7	4.3	-1.6	-1.6	-1.7	1.8	1.3	2.1	1.3
Sitting height	0.4	2.5	8.7	0.2	-1.1	-1.5	2.0	2.9	0.1	1.3
Chronic bronchitis/emphysema (father)	0.5	0.5	1.7	0.6	1.1	1.3	-0.4	-0.2	-0.3	-0.4
High blood pressure (mother)	0.3	0.4	0.6	-0.7	-0.7	-0.8	0.4	0.6	0.5	0.5
Body mass index (BMI)	0.3	1.2	3.8	-1.9	-0.6	-1.1	0.6	1.1	0.9	0.8
Impedance of leg (left)	1.4	6.7	16.2	4.0	1.6	1.1	-2.1	-2.1	-2.9	-3.1
Leg predicted mass (left)	0.2	1.3	4.0	-0.6	-0.7	-0.9	1.6	2.0	0.5	0.8
Trunk fat mass	0.2	0.8	2.9	-0.3	-0.5	-1.1	0.9	1.7	0.2	0.4
Waist circumference	0.2	0.8	1.8	0.3	0.6	-0.3	-1.1	-0.6	-1.3	-1.4
Number of incorrect matches in round	1.2	1.9	3.8	-1.6	-0.7	-0.6	1.5	1.4	1.9	1.4
Past tobacco smoking	3.7	6.9	9.0	2.4	2.6	2.5	-2.6	-2.4	-3.0	-2.8
Alcohol usually taken with meals	0.7	1.1	1.7	-0.3	-1.3	-1.0	1.3	0.9	1.2	0.9
Nervous feelings	0.5	0.9	2.3	-1.2	-0.1	0.4	1.1	0.7	1.0	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.5	1.2	1.6	1.0	-1.2	-1.0	-1.3	-1.1
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.2	0.0	-0.1	-0.5	-0.6	-0.1	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	1.1	1.2	1.9	-0.5	-0.4	-1.0	-1.1
Had menopause	0.6	0.8	1.4	-0.5	-0.8	-0.6	1.0	1.2	1.1	0.8
Had other major operations	0.7	0.8	1.9	-1.0	-0.5	-0.2	1.4	0.7	1.0	1.1
Forced vital capacity (FVC)	0.3	1.0	2.4	0.7	1.0	1.1	-0.5	-0.8	-1.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	5.5	12.6	21.2	4.1	2.7	2.2	-3.9	-2.9	-4.6	-3.9
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.9	-1.7	-1.1	-0.6	1.7	1.0	2.2	1.5
Qualifications: None of the above	1.0	2.2	4.7	-2.2	-0.5	-0.7	1.2	1.1	2.1	1.8
Financial difficulties in last 2 years	0.2	0.3	0.7	0.7	0.9	0.6	-0.4	-0.1	-0.1	-0.4
Mouth/teeth dental problems	0.1	0.1	0.4	0.5	-0.0	0.2	0.3	-0.1	-0.6	-0.0
Heart attack	2.6	3.3	5.3	1.8	1.0	0.5	-2.3	-1.7	-2.3	-2.3
Allergy	2.1	4.9	7.6	2.0	1.8	0.9	-2.6	-2.7	-2.8	-2.1
Pain all over the body in last month	0.8	0.9	2.4	-1.5	-0.2	-0.0	0.7	0.8	1.4	0.7
Diabetes (self-reported)	3.2	4.9	7.4	1.6	1.7	1.2	-2.7	-2.7	-2.6	-2.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.1	-1.7	-1.1	-0.8	1.4	1.7	1.7	1.8
Medication: Ramipril	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.1	-0.5	-0.3	-0.5
Medication: Simvastatin	0.7	1.0	2.5	0.8	0.4	-0.0	-1.6	-1.3	-1.2	-0.9
Fluid intelligence score	0.9	1.9	3.4	-1.0	-1.8	-1.6	1.2	1.1	1.0	1.6
Illnesses of siblings	0.3	0.4	1.2	-0.1	-1.1	-1.1	-0.1	0.1	-0.4	-0.1
Neuroticism score	0.2	0.4	0.6	-0.6	0.7	0.6	0.5	0.0	0.8	0.6
Weight	0.1	0.7	2.2	-0.2	-0.5	-1.2	0.9	1.5	-0.3	0.0
Impedance of arm (right)	0.1	0.5	1.6	1.2	0.6	1.1	0.0	0.3	-0.4	0.0
Arm fat percentage (right)	0.4	1.5	3.4	-1.8	-0.7	-1.2	0.8	1.5	1.1	1.2
Trunk fat-free mass	0.2	1.0	2.1	0.3	-0.9	-1.4	1.4	1.4	-0.4	-0.1
Hip circumference	1.9	8.3	12.6	-2.4	-2.9	-3.2	3.0	3.6	2.4	2.5
Time employed in main current job	0.3	0.4	0.9	-0.3	-0.8	-0.9	0.6	0.3	0.5	0.5
Alcohol intake versus 10 years previously	0.6	0.9	2.0	-1.2	0.1	0.2	0.7	1.1	1.4	0.8
Father’s age at death	0.5	0.6	2.3	-0.5	-1.3	-1.5	-0.3	-0.3	0.1	-0.2
Worrier / anxious feelings	1.9	3.5	10.4	1.3	3.2	3.2	-1.0	-0.6	-0.6	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	0.9	0.9	0.6	-0.9	-1.1	-0.8	-1.2
Falls in the last year	0.3	0.4	0.9	-0.5	0.9	0.7	-0.5	-0.4	0.0	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	0.9	0.4	0.5	-0.9	-0.9	-0.8	-0.7
Number of live births	0.4	0.6	1.1	0.9	0.1	-0.8	-1.0	-0.6	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.6	1.4	1.2	1.2	-1.3	-1.5	-2.1	-1.7
Pulse rate	3.7	6.2	8.7	2.8	2.6	2.2	-2.5	-1.9	-2.9	-2.4
Happiness	2.0	2.4	4.0	1.8	1.5	1.4	-1.0	-1.4	-1.5	-2.0
Noisy workplace	0.1	0.1	0.3	-0.5	0.1	-0.0	-0.3	0.1	0.4	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.5	0.4	-1.2	-1.1	0.3	0.2	0.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.6	0.4	0.6	-0.0	-0.5	-0.0	0.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.1	-0.2	-0.7	-0.4	0.1	0.2	-0.3
Asthma	0.2	0.5	1.3	-0.7	0.5	0.9	0.6	0.2	1.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	0.5	-0.5	-0.9	0.4	0.1	0.1	-0.2
Medication: Cholesterol lowering	0.5	0.7	1.4	1.2	0.0	-0.3	-1.1	-0.6	-1.0	-1.0
Depression (self-reported)	3.8	4.6	6.2	-2.1	-2.5	-2.1	1.9	2.2	2.2	1.9
Medication: Lansoprazole	7.0	7.9	11.2	2.4	2.7	2.0	-3.2	-3.2	-2.6	-3.3
Prospective memory result	0.3	0.3	1.1	0.2	0.3	-0.1	-0.7	-1.1	-0.4	-0.7
Lung cancer (father)	0.1	0.2	0.6	-0.0	0.7	0.8	-0.1	-0.1	0.2	0.2
Illnesses of mother	0.1	0.2	0.6	0.2	-0.4	-0.8	0.2	-0.5	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	6.9	1.9	1.5	1.3	-1.8	-2.1	-2.6	-2.1
Pulse wave Arterial Stiffness index	1.7	2.0	4.3	2.1	1.3	1.2	-0.9	-1.0	-1.2	-1.7
Impedance of arm (left)	0.2	1.0	2.7	1.6	1.1	1.6	-0.3	-0.0	-0.7	-0.3
Arm fat mass (right)	0.2	0.9	2.3	-1.2	-0.5	-1.1	0.8	1.5	0.5	0.7
Trunk predicted mass	0.2	0.9	1.9	0.6	-0.8	-1.4	1.2	1.3	-0.6	-0.3
Standing height	0.4	3.9	15.2	3.9	0.2	-0.3	0.8	1.0	-2.6	-1.8
Length of working week for main job	0.5	0.5	1.2	0.3	1.1	1.1	-0.5	-0.7	-0.6	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.5	0.1	-0.1	0.8	0.5	0.9	0.5
Breastfed as a baby	4.4	5.4	7.8	-1.5	-2.8	-2.4	2.5	2.2	2.3	2.4
Tense / ‘highly strung’	0.2	0.3	0.7	0.8	0.3	0.2	-0.2	-0.8	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.2	-1.6	-0.9	-0.5	1.9	1.6	2.1	1.4
Hair/balding pattern: Pattern 4	1.6	3.8	5.0	-2.0	-2.2	-2.2	1.6	1.7	2.1	1.7
Birth weight of first child	1.7	3.1	6.7	-1.6	-0.9	-0.2	2.0	2.6	1.6	2.2
Peak expiratory flow (PEF)	0.3	0.6	1.6	-1.3	0.3	0.7	0.5	0.5	0.8	0.9
Pulse wave reflection index	2.3	2.8	3.6	-1.8	-1.9	-1.7	1.8	1.2	1.8	1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.0	-1.1	-0.5	-0.2	1.4	1.2	1.1	1.1
Loud music exposure frequency	0.3	0.3	0.8	0.6	0.8	0.9	-0.1	-0.5	-0.0	-0.2
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	5.7	2.0	0.7	0.5	-1.5	-1.7	-1.4	-2.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.6	0.5	1.1	1.1	-1.0	-1.0	-0.3	-1.3
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.3	0.5	1.0	-0.8	-0.4	-0.3	-0.2
Medication: Paracetamol	0.5	0.9	2.1	-0.1	1.2	1.5	0.6	0.9	0.9	0.6
Headache pain in last month	1.2	2.0	3.3	1.4	1.5	1.2	-1.2	-1.8	-1.3	-1.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	-0.8	0.1	0.3	0.7	0.4	0.8	0.8
Glaucoma (self-reported)	0.0	0.1	0.2	0.1	-0.2	-0.4	-0.3	0.1	0.2	-0.1
Gout (self-reported)	0.2	0.2	0.8	0.9	0.2	0.1	-0.6	-0.3	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.0	-1.2	-1.2	-1.7	1.2	0.8	2.0	0.9
Medication: Amlodipine	0.3	0.4	1.2	-0.0	0.1	-0.2	0.9	1.1	0.9	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	0.2	0.4	-0.1	-0.1	0.3	-0.0
Birth weight	4.5	9.8	14.8	-2.6	-2.8	-1.9	3.9	3.6	3.2	3.5
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.9	0.3	1.7	1.4	-0.5	-0.9	-0.6	-0.7
High blood pressure (siblings)	0.1	0.1	0.3	-0.4	-0.0	-0.0	0.6	0.5	0.3	0.2
Forced vital capacity (FVC), Best measure	1.0	3.5	5.6	1.7	1.8	1.8	-1.5	-1.8	-2.4	-2.0
Body fat percentage	0.1	0.4	1.5	-0.6	-0.3	-0.8	0.3	1.2	0.3	0.3
Leg fat percentage (right)	0.2	0.6	2.0	-0.7	-0.7	-1.4	0.2	0.9	0.4	0.2
Arm fat-free mass (right)	0.2	0.8	1.7	1.0	-0.6	-1.3	0.6	0.8	-0.9	-0.8
Exposure to tobacco smoke outside home	0.7	0.9	2.0	1.0	1.4	1.4	-0.6	-0.7	-0.5	-0.7
Comparative body size at age 10	4.1	11.3	17.4	-3.7	-4.0	-4.2	2.8	2.3	3.0	3.2
Number of full brothers	0.4	0.5	1.6	1.3	0.8	0.5	-0.3	-0.5	-0.5	-0.4
Worry too long after embarrassment	2.0	3.4	5.3	1.0	2.1	1.7	-2.1	-2.3	-1.4	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.5	-1.1	-1.2	-1.0	1.2	0.8	1.2	0.8
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.8	0.4	0.6	0.5	0.5	0.9	0.3
Number of children fathered	0.5	0.5	1.4	0.9	0.1	-0.1	-0.5	-1.2	-0.8	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.2	0.0	0.2	0.2	0.4	0.4	-0.1
Age at first live birth	0.2	0.3	1.1	1.0	-0.4	0.1	0.3	0.3	-0.8	-0.1
Pulse wave peak to peak time	1.1	1.3	2.6	-1.6	-1.1	-1.0	0.8	0.9	0.9	1.4
Health satisfaction	0.1	0.1	0.3	0.4	-0.3	-0.6	0.1	0.2	-0.4	-0.4
Shortness of breath walking on level ground	0.2	0.3	0.6	-0.2	-0.4	-0.7	0.4	0.6	0.6	0.3
Qualifications: College or University degree	1.8	5.8	12.6	2.9	0.9	1.4	-2.4	-2.4	-3.5	-2.3
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.0	0.2	0.6	0.9	0.9	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.2	0.2	-0.3	-0.6	-0.3	-0.7	-0.8
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.3	-0.1	0.1	0.4	0.6	0.1	0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	-0.4	-1.2	-0.9	-0.1	-0.3	-0.4	-0.0
Neck or shoulder pain in last month	1.1	1.6	3.0	1.4	0.9	0.5	-1.3	-1.3	-1.3	-1.7
Medication: Blood pressure	0.2	0.3	1.0	0.6	-0.8	-1.0	0.1	0.1	-0.1	-0.5
Angina (self-reported)	1.9	2.5	4.4	1.6	1.4	1.2	-1.7	-1.2	-2.1	-1.7
Migraine (self-reported)	0.1	0.1	0.2	-0.4	-0.2	-0.4	-0.2	-0.1	0.3	0.5
Medication: Ibuprofen	1.1	1.3	4.0	-0.2	-1.6	-2.0	1.0	0.7	0.7	0.4
Medication: Allopurinol	0.3	0.3	1.8	1.4	0.3	0.2	0.0	-0.1	-0.6	-0.2
Medication: Omeprazole	0.6	0.7	1.3	-1.1	0.8	1.1	0.3	0.4	1.0	0.7
Medication: Seretide 50 evohaler	2.0	2.4	4.8	-1.3	-0.3	-0.2	1.9	1.8	2.2	1.8
Mean time to correctly identify matches	6.1	11.6	16.0	4.0	3.0	2.1	-3.6	-3.9	-3.3	-3.5
Heart disease (mother)	0.2	0.3	0.8	0.3	0.3	0.3	-0.9	-0.1	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	-0.6	0.8	0.8	0.7	0.2	0.7	0.6
Whole body fat mass	0.1	0.5	2.2	-0.4	-0.2	-0.8	0.7	1.5	0.2	0.3
Leg fat mass (right)	0.1	0.5	1.9	-0.3	-0.5	-1.4	0.3	1.0	-0.1	-0.1
Arm predicted mass (right)	0.2	0.9	2.0	1.0	-0.7	-1.4	0.7	0.9	-0.9	-0.8
Pulse rate, automated reading	1.6	5.1	8.2	2.9	2.1	2.1	-2.0	-1.6	-2.8	-2.1
Alcohol intake frequency.	0.6	1.3	4.4	0.3	1.9	2.1	-0.7	-0.1	-0.7	-0.6
Comparative height size at age 10	0.5	2.9	11.4	3.4	0.4	0.2	0.6	0.7	-2.3	-1.6
Number of full sisters	0.3	0.4	0.7	-0.4	0.0	-0.6	-0.5	-0.8	0.8	-0.7
Suffer from ‘nerves’	1.3	2.0	4.0	-1.5	-0.7	-0.4	1.6	1.1	2.0	1.9
Overall health rating	1.5	3.2	5.9	1.3	2.4	1.7	-2.0	-1.5	-1.0	-2.3
Chest pain or discomfort	1.3	1.8	3.9	1.1	1.6	2.0	-1.1	-1.0	-0.9	-1.4
Had major operations	0.1	0.1	0.7	0.0	0.2	-0.1	0.1	-0.2	0.8	-0.0
Age at last live birth	0.4	0.6	1.0	0.4	-0.9	-0.3	0.9	1.0	-0.1	1.0
Family relationship satisfaction	0.6	0.7	1.1	0.9	0.9	1.0	-0.3	-0.8	-0.6	-1.0
Leg pain on walking	1.8	2.3	4.3	2.0	0.4	-0.4	-1.4	-1.4	-1.8	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	0.1	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.0	-0.1	1.0	1.4	0.7	0.3	0.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.9	-0.2	0.2	0.6	1.0	0.5	0.8
Medication: Aspirin	0.8	1.0	1.9	1.4	1.0	0.9	-0.9	-0.8	-1.0	-1.0
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	0.3	-0.0	-0.0	-0.5	0.0	-0.4
Knee pain experienced in last month	3.0	4.7	7.2	2.0	2.0	1.5	-2.2	-2.4	-2.2	-2.7
Hypertension (Self-reported)	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.2	0.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	4.8	0.3	1.6	2.2	-0.2	-0.6	-0.3	-0.2
Illnesses of father: Heart disease	0.2	0.2	0.7	-0.8	-0.5	-0.3	0.1	-0.3	-0.4	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.3	0.9	0.8	-0.3	-0.4	-0.2	-0.2
Smoking status: Previous	4.4	6.6	7.9	-2.3	-2.6	-2.4	2.7	2.4	2.8	2.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.4	2.1	0.7	0.4	-0.3	-0.6	-1.5	-1.8
Whole body fat-free mass	0.2	1.1	2.5	0.0	-1.0	-1.4	1.4	1.6	-0.2	0.1
Leg fat-free mass (right)	0.2	1.1	3.5	-0.7	-0.6	-0.8	1.5	1.9	0.4	0.7
Arm fat percentage (left)	0.3	1.1	2.8	-1.7	-0.4	-0.8	0.5	1.4	0.9	1.0
Average weekly red wine intake	0.6	0.9	3.2	-0.6	-1.6	-1.8	0.4	0.3	0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.6	-0.4	-0.2	-0.1	0.1	-0.2	-0.1
Mood swings	0.2	0.3	1.6	0.3	1.2	0.7	-0.3	-0.0	-0.2	-0.3
Loneliness, isolation	0.2	0.2	0.6	-0.4	0.8	0.6	0.4	-0.1	0.5	-0.1
Long-standing illness, disability or infirmity	0.5	0.7	1.6	0.7	0.7	0.3	-1.1	-0.9	-0.5	-1.3
Ever had bowel cancer screening	0.1	0.1	0.2	-0.1	0.3	0.0	-0.5	-0.5	0.3	-0.1
Diabetes diagnosed by doctor	4.9	8.0	11.6	2.3	2.2	1.6	-3.4	-3.3	-3.2	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.9	0.2	-1.5	-1.7	0.7	0.4	0.4	0.5
Friendships satisfaction	1.8	2.3	3.2	1.8	1.1	1.2	-1.6	-1.4	-1.6	-1.7
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.4	-0.2	0.3	0.4	0.2	0.6	0.5
Commuting to job workplace: Walk	1.5	1.6	5.9	-1.1	-2.0	-2.4	-0.2	0.1	0.2	0.2
Eye problems/disorders: Cataract	1.2	1.3	2.5	-1.6	-1.4	-1.3	0.5	0.6	1.3	1.0
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	3.7	-1.9	-1.8	-1.4	1.6	1.3	1.9	1.9
Medication for cholesterol	1.8	2.7	6.2	-0.6	-2.5	-2.1	1.6	1.3	0.9	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.2	-1.1	0.3	0.3	-0.0	0.2	0.5	0.2
Back pain experienced in last month	0.9	1.3	4.3	0.4	2.1	1.7	-0.8	-0.4	-0.4	-0.6
Mineral and other dietary supplements	3.0	4.1	5.0	2.0	1.9	1.5	-2.2	-2.1	-2.2	-2.1
Breast cancer (self-reported)	1.7	2.0	3.8	-1.3	-0.8	-0.4	2.0	1.2	1.9	1.6
Asthma (self-reported)	0.2	0.5	1.4	-0.7	0.4	0.8	0.7	0.2	1.2	0.4
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.8	-0.3	0.2	0.7	0.3	1.2	0.7
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.7	0.1	0.0	-0.6	-0.4	-0.5	-0.9
Medication: Aspirin	0.8	1.0	1.5	1.2	0.9	0.9	-1.0	-0.9	-1.0	-1.0
Medication: Gliclazide	1.2	1.4	2.8	0.7	0.6	0.2	-1.7	-1.4	-1.4	-1.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.4	0.7	0.5	-0.7	-0.1	0.0	-0.5
Smoking status: Current	0.1	0.2	0.5	0.6	-0.1	-0.7	-0.2	-0.6	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.3	0.2	1.3	1.5	-1.3	-1.3	-1.4	-0.9
Whole body water mass	0.2	1.0	2.4	0.1	-0.9	-1.4	1.4	1.6	-0.3	0.1
Leg predicted mass (right)	0.2	1.1	3.4	-0.7	-0.6	-0.8	1.5	1.8	0.4	0.6
Arm fat mass (left)	0.1	0.6	1.7	-0.9	-0.3	-0.9	0.5	1.3	0.2	0.4
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	0.2	-0.0	0.1	0.4	-0.0	0.5	0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.8	-0.2	-0.0	0.9	1.0	0.9	1.1
Miserableness	0.2	0.4	0.8	-0.3	-0.3	-0.6	0.7	0.6	0.6	0.9
Guilty feelings	0.3	0.5	1.7	-0.5	0.2	0.5	1.0	0.5	1.3	0.3
Wears glasses or contact lenses	0.9	1.0	1.8	-0.6	-1.1	-0.7	0.9	0.9	1.3	1.3
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.4	0.9	0.8	-0.8	-1.0	-0.1	-0.6
Hearing aid user	1.9	2.2	2.9	1.2	1.7	1.5	-1.5	-1.6	-1.1	-1.7
Mother’s age at death	0.3	0.4	1.0	0.3	0.8	1.0	-0.8	-0.5	-0.4	-0.4
Financial situation satisfaction	5.1	6.3	10.7	3.0	1.7	1.1	-2.7	-2.3	-3.3	-2.8
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.8	1.1	1.7	2.0	-1.5	-1.5	-1.3	-1.1
Commuting to job workplace: Public transport	2.4	2.8	5.3	-0.7	-2.3	-2.3	1.5	1.6	1.4	1.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.4	0.1	-0.0	-0.6	-0.3	-0.5	-0.3
Medication: Blood pressure	0.2	0.3	0.9	-0.6	0.8	0.9	-0.1	-0.1	0.5	-0.3
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.8	1.9	0.9	0.6	-1.0	-1.2	-1.4	-1.5
Supplements: Fish oil (including cod liver oil)	4.7	6.1	7.5	-2.1	-2.7	-2.5	2.4	2.6	2.4	2.4
High cholesterol (Self-reported)	0.7	1.2	2.9	1.7	0.8	0.6	-1.1	-0.4	-1.5	-0.9
Medication: Bendroflumethiazide	0.4	0.6	1.3	-0.9	-0.0	0.2	0.8	1.0	1.1	0.7
Medication: Paracetamol	0.8	1.2	3.4	-0.5	1.3	1.9	0.7	1.0	0.8	1.0
Medication: Lisinopril	0.6	0.8	2.4	0.3	1.5	1.5	-0.4	-0.9	-0.3	-0.4
Medication: Atorvastatin	0.6	0.8	2.2	0.6	1.4	1.5	-0.5	-0.2	-0.6	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.9	-0.2	-0.5	-0.3	-0.8	-0.7	-0.8
Alcohol drinker status: Never	2.2	2.6	4.4	1.4	2.0	2.1	-1.6	-1.0	-1.6	-1.4
Ever smoked	5.5	9.6	12.8	-3.0	-2.8	-2.5	3.3	3.0	3.6	3.3
Basal metabolic rate	0.2	0.9	2.6	0.0	-0.7	-1.3	1.3	1.6	-0.2	0.1
Leg fat percentage (left)	0.1	0.4	1.3	-0.8	-0.4	-1.1	0.1	0.8	0.3	0.1
Arm fat-free mass (left)	0.2	1.0	2.9	0.8	-0.9	-1.7	0.7	1.0	-0.9	-0.7
Number of operations (self-reported)	0.2	0.3	1.3	0.2	-0.2	-0.8	0.4	0.1	1.1	0.3
Average weekly beer plus cider intake	0.4	0.6	1.5	0.8	-0.6	-1.2	-0.1	-1.1	-0.0	-0.6
Irritability	0.3	0.5	1.0	0.5	0.9	0.4	-0.6	-1.0	-0.4	-0.7
Risk taking	1.7	2.4	4.0	1.1	1.3	0.7	-1.8	-1.9	-1.7	-2.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-0.5	-1.3	-1.3	0.5	0.6	0.0	0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.8	0.1	0.1	0.1	0.5	0.9	0.3
Age started oral contraceptive pill	0.2	0.3	0.8	-0.8	-0.4	0.2	0.3	0.9	0.4	0.3
Diastolic blood pressure, automated reading	0.5	1.5	4.0	2.0	0.9	0.1	-0.9	-1.1	-1.4	-1.5
Ever depressed for a whole week	2.1	2.6	3.9	-1.5	-1.8	-1.5	1.7	1.2	2.0	1.3
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.1	0.5	0.0	-0.7	-0.7	0.1	-0.5
Commuting to job workplace: Cycle	0.5	0.6	1.6	1.0	0.8	1.3	-0.1	-0.3	-0.8	0.0
Myopia	4.1	5.9	10.1	-2.8	-1.9	-1.4	2.3	2.4	3.2	2.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.4	-0.0	0.2	-0.0	0.0	-0.1	0.4
Cholesterol lowering medication	2.9	4.3	6.3	1.7	2.1	1.7	-2.3	-2.2	-2.5	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.1	-0.4	1.1	1.1	-0.1	0.2	0.7	0.2
Pain experienced in last month	2.1	3.5	5.5	-1.2	-2.3	-1.8	1.8	2.1	1.4	2.1
Supplements: Calcium	1.5	1.6	2.9	-1.1	-1.7	-1.0	1.5	1.0	1.3	1.2
Basal cell carcinoma (self-reported)	1.5	1.7	2.8	-1.4	-0.8	-0.6	1.4	1.7	1.4	1.6
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.3	1.6	0.9	0.4	-2.1	-1.4	-2.1	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.5	0.4	0.9	-0.7	-0.5	-0.4	-0.4
Heart disease (siblings)	0.5	0.6	1.4	-0.6	0.6	0.9	0.4	0.4	1.2	0.8
Alcohol drinker status: Previous	2.5	2.8	4.8	-1.7	-2.0	-2.2	1.4	1.4	1.3	1.5
Pack years of smoking	1.3	1.9	4.5	1.4	2.1	1.8	-0.9	-0.8	-1.2	-0.9
Impedance of whole body	0.7	3.7	9.7	3.1	1.6	1.5	-1.4	-1.2	-2.0	-1.9
Leg fat mass (left)	0.1	0.3	1.0	-0.3	-0.2	-1.0	0.1	0.8	-0.2	-0.2
Arm predicted mass (left)	0.2	0.9	2.4	0.6	-0.7	-1.6	0.8	1.1	-0.8	-0.6