Hub : Genes

CCDC130

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1740	0.0660	0.00660	-0.003	NA	-0.003	NA	0.003	5.1e-01	NA	4.7e-01	NA	2.1e-01
2	GTEx	Breast Mammary Tissue (Male)	0.2541	0.1052	0.02900	-0.001	NA	0.050	NA	-0.011	3.4e-01	NA	2.7e-02	NA	6.9e-01
3	GTEx	Thyroid	0.1160	0.0380	0.00074	0.076	NA	0.056	NA	0.058	1.9e-06	NA	4.1e-05	NA	3.1e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0887	0.0302	0.00065	0.004	0.021	0.002	0.023	0.002	1.0e-01	9.3e-04	1.5e-01	5.1e-04	1.8e-01
5	YFS	Blood	0.1280	0.0239	0.00000	0.104	0.067	0.093	0.096	0.100	4.6e-32	6.1e-21	9.6e-29	1.2e-29	6.6e-31

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.9	-0.2	0.3	0.3	0.9	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	1.3	0.1	1.1	0.2	0.4	0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.9	0.9	0.2	-0.2	0.2
Depression (Nagel 2018)	0.5	0.8	1.2	1.1	1.0	0.7	-0.9	0.8
Intelligence (Savage-Jansen 2018)	1.0	3.2	5.8	-1.3	1.3	2.1	-1.6	2.4
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.1	0.9	0.5	-0.0	0.7
Schizophrenia (2018)	0.2	0.4	1.6	0.3	1.3	-0.1	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.7	0.0	0.8	0.4	1.1
Worry (Nagel 2018)	0.2	0.3	0.7	-0.8	0.8	0.1	0.5	0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	-0.7	0.8	0.7	-1.1	0.5
Alzheimer’s Disease (in father)	1.2	1.3	5.2	0.7	-2.3	-0.5	0.3	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	1.5	0.1	-1.2	0.3	-0.0	0.2
Crohns Disease (2017)	0.1	0.3	0.8	-0.5	0.9	0.4	-0.2	0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.2	-0.1	0.0	0.0	-0.4	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.7	-0.5	-0.8	-0.4	-0.1	-0.1
Major Depression (MDD)	1.7	2.0	6.0	2.5	1.3	0.3	-1.5	0.1
Reaction Time	3.0	5.8	11.2	-1.3	-0.7	-2.8	-2.7	-3.3
Verbal and Numeric Reasoning (VNR)	1.5	3.6	6.9	-1.6	0.2	2.4	-1.6	2.6
Breast Cancer	1.8	4.3	10.5	0.5	-0.5	-3.2	0.9	-3.1
Ovarian Cancer	0.4	0.5	0.8	0.9	-0.6	0.8	0.5	0.8
Prostate Cancer	0.7	1.0	2.6	-0.3	1.6	0.7	-1.0	0.7
Age at First Birth	2.2	3.2	6.3	-0.7	0.3	-2.1	-2.5	-2.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.0	1.0	-0.5	0.7	0.7	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	-0.8
Crohns Disease (2012)	0.7	1.1	2.9	0.1	0.3	1.7	-0.8	1.4
Mean Putamen Volume	1.4	1.6	6.5	2.5	0.2	0.8	-0.1	0.8
Fasting Glucose	1.0	1.2	3.0	0.6	-0.3	1.7	0.2	1.6
HbA1C	1.5	1.7	7.1	2.7	-1.2	0.2	-0.2	0.2
HDL Cholesterol	0.3	0.5	0.8	-0.9	-0.5	-0.6	0.6	-0.7
LDL Cholesterol	1.3	2.1	7.6	0.2	-0.6	1.2	2.8	1.0
Lupus	0.7	1.0	3.3	0.9	1.8	-0.7	0.4	-0.6
Neuroticism (2016)	0.3	0.4	0.6	0.7	0.5	-0.7	-0.1	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.4	-0.9	-0.4	0.5	-0.4
Rheumatoid Arthritis	0.5	0.7	2.1	-0.8	1.4	0.2	1.0	0.0
Schizophrenia (2014)	0.2	0.4	1.5	0.3	1.2	-0.2	-0.8	-0.0
Triglycerides	1.0	1.6	4.6	2.1	1.3	0.8	0.7	0.7
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.3	-0.1	-1.0	1.5	0.7	1.3
Ulcerative Colitis	0.3	0.5	1.4	-1.2	-0.9	0.0	-0.2	0.0
Blood Eosinophil Count	0.2	1.3	2.2	-0.6	-1.5	-0.7	-1.4	-1.3
Blood Platelet Count	0.3	3.0	7.7	0.7	-2.8	-1.4	1.5	-1.7
Blood Red Count	0.3	2.8	7.6	1.7	1.3	-0.9	-2.8	-1.1
Blood White Count	0.5	3.3	11.3	0.9	-3.4	-0.7	1.8	-1.0
Heel T-Score	0.1	0.5	1.8	0.1	-0.7	-0.5	-1.3	0.1
BMI	0.7	3.9	8.3	0.8	-2.9	-2.0	-0.1	-2.6
Height	0.3	6.5	10.6	1.0	3.0	3.2	-1.4	3.2
Waist Hip Ratio (WHR)	0.1	0.4	0.8	-0.3	-0.8	0.6	-0.9	0.5
Systolic Blood Pressure	0.1	0.4	0.6	-0.8	-0.3	-0.8	-0.3	-0.6
Smoking Status	0.3	0.8	2.1	0.6	1.5	0.5	-1.1	-0.1
Allergy or Eczema	0.5	1.3	2.6	0.9	0.5	-1.5	-0.7	-1.6
Cardiovascular Disease	1.4	4.6	12.1	0.3	-0.3	-3.5	-0.1	-3.3
Hypothyroidism (self reported)	0.2	0.4	1.1	0.0	0.7	-0.8	0.1	-1.0
Respiratory disease	0.4	0.9	2.8	1.7	0.9	-0.3	0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.7	1.6	0.8	0.9	-0.5	1.2
Lung FEV1/FVC ratio	0.4	2.2	4.0	0.3	0.9	2.0	-1.6	1.9
Lung FVC	0.1	0.7	2.0	-1.4	0.1	-0.7	0.6	-0.8
Neuroticism	0.2	0.4	0.6	-0.7	0.4	0.5	0.4	0.8
Chronotype (morning person)	0.4	0.9	1.3	-0.3	1.1	0.9	1.0	1.1
Hair Pigment	0.0	1.4	2.5	1.6	-1.6	-0.9	0.3	-1.1
Tanning	0.0	0.5	1.0	-0.4	0.1	-0.8	-1.0	-0.7
Hand grip strength (left)	0.8	2.1	10.2	0.1	3.2	-0.4	-0.4	-0.2
Number of treatments/medications taken	0.1	0.1	0.2	-0.4	0.4	-0.1	0.3	-0.5
Average weekly spirits intake	0.7	0.8	2.6	1.6	1.0	-0.4	-0.5	-0.3
Sensitivity / hurt feelings	0.5	0.9	1.3	-1.1	-0.4	0.9	1.0	1.1
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.2	0.2	1.5	1.4	-1.3	1.4
Hearing difficulty/problems: Yes	0.6	1.0	3.4	0.6	-0.1	0.7	1.9	0.8
Relative age of first facial hair	0.4	0.7	1.7	-1.1	-0.1	0.7	1.3	0.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.5	-0.1	1.5	-1.5	0.5	-1.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	1.2	-0.7	0.5	0.4	0.6
Ever had hysterectomy (womb removed)	0.7	0.7	3.1	-0.1	1.8	-0.1	-0.7	0.1
Systolic blood pressure, automated reading	0.1	0.3	1.2	0.1	-0.1	-0.3	-1.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	1.0	0.2	0.9	-0.6	0.6
Angina	0.5	0.7	1.0	-0.7	0.6	-1.0	-0.7	-1.0
Medication for hormone replacement therapy	1.8	2.0	7.0	2.6	-1.5	0.6	-0.3	0.7
Vitamin and mineral supplements	0.3	0.4	1.1	1.1	0.0	0.5	0.2	0.8
Supplements: Zinc	0.9	1.0	4.2	-0.6	-0.4	-0.0	-2.1	0.1
Medication: Co-codamol	0.2	0.2	0.7	-0.7	-0.8	0.3	0.0	0.0
Medication: Metformin	1.7	2.5	5.2	2.3	-0.1	1.7	-0.0	2.0
Diabetes (father)	1.1	1.4	2.3	-1.5	0.5	-1.4	-1.0	-1.2
Diabetes (mother)	1.0	1.2	3.5	0.9	-1.3	0.1	1.9	0.3
Severe depression (siblings)	1.4	1.6	4.5	-0.5	-2.1	1.3	-0.4	1.2
Pack years adult smoking proportion	0.2	0.2	0.6	-0.5	-0.5	0.2	0.8	-0.1
Impedance of leg (right)	0.3	1.2	2.7	-1.0	0.5	1.3	0.7	1.6
Leg fat-free mass (left)	0.1	0.6	1.0	1.0	-0.7	-0.4	-0.6	-1.0
Trunk fat percentage	1.5	5.9	26.5	0.9	-5.1	-0.2	1.3	-0.6
Hand grip strength (right)	0.8	2.2	10.0	-0.2	3.2	-0.5	-0.9	-0.1
Townsend deprivation index at recruitment	0.4	0.6	2.1	-1.4	-0.7	0.7	-0.1	0.3
Current tobacco smoking	0.3	0.5	1.4	-0.4	0.9	0.1	-1.2	-0.2
Average weekly fortified wine intake	1.6	1.8	3.5	-1.1	0.4	-1.9	-1.3	-1.6
Maternal smoking around birth	0.9	1.3	2.7	0.1	0.0	1.4	1.6	1.4
Fed-up feelings	0.8	1.5	4.5	2.1	1.3	0.8	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.0	0.3	0.3	1.0	-0.1	0.8
Relative age voice broke	0.1	0.2	0.7	0.0	0.2	0.2	0.9	0.5
Taking other prescription medications	0.5	0.8	1.6	-0.7	0.2	1.0	1.3	0.8
Age when periods started (menarche)	0.8	2.0	3.1	1.8	0.8	-1.4	-1.8	-1.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.9	0.8	1.4	-0.4	-1.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.4	-1.2	0.9	-1.9	-1.7	-1.5
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	6.4	2.1	2.5	-0.1	-2.1	-0.1
Qualifications: CSEs or equivalent	0.3	0.5	1.3	-0.0	0.3	-0.7	-1.1	-0.6
Serious illness, injury or assault to yourself	0.3	0.3	0.5	-0.5	0.7	-0.7	-0.3	-0.7
High blood pressure	0.7	2.1	3.9	-1.0	-1.2	-2.0	-0.7	-1.9
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.6	-0.3	0.3	-1.9	-0.1	-2.1
Multivitamins +/- minerals	0.4	0.6	1.7	-0.1	0.2	-1.0	-0.0	-1.3
Stomach or abdominal pain in last month	3.6	4.5	9.2	-0.4	3.0	-2.1	-1.9	-2.2
Supplements: Glucosamine	0.1	0.2	0.3	-0.6	0.5	0.2	0.4	0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.3	-0.4	0.4	-1.5	0.9	-1.5
Medication: Atenolol	0.9	1.1	2.8	-1.7	-1.0	-0.7	-0.6	-1.0
Medication: Levothyroxine sodium	0.4	0.6	2.9	-0.3	0.1	0.2	1.7	-0.2
Sitting height	0.8	5.4	11.1	0.2	2.4	3.3	0.4	3.2
Chronic bronchitis/emphysema (father)	0.8	1.0	1.8	-0.3	0.0	-1.4	-1.1	-1.3
High blood pressure (mother)	0.8	1.2	2.8	-0.9	1.7	0.2	-1.4	0.2
Body mass index (BMI)	1.1	4.8	14.3	1.9	-3.8	-1.4	0.5	-1.9
Impedance of leg (left)	0.4	1.8	4.3	-1.0	0.8	1.7	0.6	2.1
Leg predicted mass (left)	0.1	0.6	1.1	1.1	-0.7	-0.4	-0.6	-1.0
Trunk fat mass	1.0	4.1	18.0	1.1	-4.2	-0.2	1.1	-0.6
Waist circumference	0.6	2.1	9.5	0.9	-3.1	0.1	-0.2	-0.4
Number of incorrect matches in round	0.7	1.2	4.8	0.1	-0.2	0.7	2.2	0.7
Past tobacco smoking	0.0	0.1	0.2	0.2	-0.3	-0.0	0.3	0.5
Alcohol usually taken with meals	0.2	0.3	0.6	-0.8	-0.4	0.3	-0.2	0.8
Nervous feelings	0.2	0.4	1.4	-0.6	-0.3	-0.1	1.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.5	0.7	0.4	-0.2	0.4
Hearing difficulty/problems with background noise	0.3	0.4	1.5	0.1	-0.1	0.6	1.2	0.3
Hair/balding pattern: Pattern 2	1.2	1.5	5.8	-0.4	-2.4	0.6	0.8	0.5
Had menopause	0.6	0.7	1.5	0.0	-0.4	1.1	0.7	1.2
Had other major operations	0.7	0.8	1.7	0.3	0.9	-1.1	0.5	-1.3
Forced vital capacity (FVC)	0.3	1.0	2.8	-0.8	1.7	-0.7	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	4.7	-0.9	0.7	-2.2	-1.6	-2.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.8	1.7	0.8	-0.1	-1.0	-0.3
Qualifications: None of the above	0.4	0.8	3.5	0.2	-0.2	-0.4	1.9	-0.6
Financial difficulties in last 2 years	0.4	0.6	1.2	-1.1	-0.9	0.4	-0.6	0.5
Mouth/teeth dental problems	0.7	1.0	2.6	-0.5	0.6	1.4	-0.2	1.6
Heart attack	0.7	0.8	2.3	1.1	1.5	0.1	-0.9	-0.2
Allergy	0.5	1.1	3.0	0.2	-0.5	1.4	0.1	1.7
Pain all over the body in last month	0.3	0.3	0.6	0.7	0.6	-0.3	0.6	-0.2
Diabetes (self-reported)	1.1	1.6	3.4	1.1	0.5	1.8	-0.1	1.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.8	0.0	2.2	-0.5	-0.1	-0.6
Medication: Ramipril	3.3	4.3	8.4	-0.9	-0.3	-2.9	-1.9	-2.9
Medication: Simvastatin	0.7	1.0	2.2	0.6	0.1	-1.5	-0.8	-1.3
Fluid intelligence score	1.4	3.0	9.4	-0.4	0.8	1.5	-3.1	1.6
Illnesses of siblings	0.4	0.6	1.6	0.8	-0.8	0.2	1.3	0.1
Neuroticism score	0.3	0.6	1.2	-1.1	-0.5	0.7	0.2	0.8
Weight	0.3	1.6	6.0	1.2	-2.5	-0.1	0.2	-0.7
Impedance of arm (right)	0.5	2.1	3.4	-1.8	-1.7	1.2	0.8	1.4
Arm fat percentage (right)	1.7	6.6	26.6	1.3	-5.2	-0.9	1.5	-1.4
Trunk fat-free mass	0.3	1.5	4.9	1.5	2.2	0.6	-0.2	0.2
Hip circumference	0.4	1.7	6.5	1.1	-2.5	0.1	0.8	-0.4
Time employed in main current job	0.7	0.8	1.6	0.1	-0.6	1.1	1.3	0.9
Alcohol intake versus 10 years previously	0.7	1.0	1.9	1.4	0.6	0.9	1.0	0.9
Father’s age at death	0.6	0.8	2.0	-1.4	0.8	-0.9	-0.1	-0.7
Worrier / anxious feelings	0.3	0.6	1.7	-1.3	-0.6	-0.7	-0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.0	0.5	-0.5	0.1	-0.5
Falls in the last year	0.4	0.5	1.1	1.0	-0.6	0.8	0.6	0.5
Hair/balding pattern: Pattern 3	0.5	0.7	1.1	-1.0	1.1	0.3	-1.0	0.4
Number of live births	0.4	0.6	1.2	-1.0	0.8	0.4	1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.7	-1.0	1.6	-0.3	-0.7	-0.2
Pulse rate	0.1	0.1	0.5	0.7	0.1	0.0	-0.0	0.3
Happiness	0.2	0.2	0.4	0.6	0.6	0.3	-0.6	0.1
Noisy workplace	1.4	1.7	3.0	-0.7	1.6	1.7	-0.5	1.5
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.9	-1.4	0.6	0.8	-0.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.1	0.8	-1.1	1.8	-0.3	2.0
Mouth/teeth dental problems: Dentures	0.8	1.3	3.7	1.9	-0.1	-1.1	-0.1	-1.2
Asthma	0.3	0.6	1.4	1.2	1.1	-0.1	0.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.1	-0.0	-0.1	-0.5	1.8	-0.3
Medication: Cholesterol lowering	0.8	1.3	3.1	-0.0	0.8	-1.2	-1.8	-1.1
Depression (self-reported)	0.5	0.6	1.2	-0.4	0.8	-0.6	1.1	-0.8
Medication: Lansoprazole	0.3	0.3	0.8	0.3	-0.0	-0.6	0.9	-0.6
Prospective memory result	1.8	2.2	5.9	-0.8	-2.1	-0.2	2.4	-0.1
Lung cancer (father)	0.5	0.5	2.3	-1.5	0.5	0.1	0.4	0.0
Illnesses of mother	0.3	0.4	0.8	0.7	-0.8	0.2	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.8	-2.0	0.9	-0.2	-0.1	-0.0
Pulse wave Arterial Stiffness index	0.7	0.9	1.7	0.4	-0.6	-1.3	-0.7	-1.3
Impedance of arm (left)	0.5	2.4	3.0	-1.7	-1.7	1.4	1.1	1.7
Arm fat mass (right)	1.2	4.8	16.6	1.8	-4.1	-1.0	0.7	-1.6
Trunk predicted mass	0.3	1.6	5.2	1.5	2.3	0.6	-0.2	0.2
Standing height	0.4	4.2	7.2	-1.0	2.7	2.6	-0.5	2.5
Length of working week for main job	0.1	0.1	0.4	-0.6	-0.2	0.4	-0.2	-0.2
Exposure to tobacco smoke at home	0.7	0.8	1.1	1.0	0.8	0.8	1.0	0.8
Breastfed as a baby	2.2	2.7	6.4	-2.5	1.4	1.4	1.3	1.4
Tense / ‘highly strung’	0.6	1.0	1.9	-1.4	-0.0	1.1	0.9	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.4	0.7	-0.1	-0.4	-0.3
Hair/balding pattern: Pattern 4	0.7	1.6	5.0	1.0	-0.7	0.9	2.2	0.9
Birth weight of first child	3.1	5.7	13.5	0.1	1.4	3.5	0.7	3.7
Peak expiratory flow (PEF)	1.1	2.6	6.9	-1.3	2.6	1.2	1.1	1.3
Pulse wave reflection index	0.7	0.9	1.8	-0.0	0.6	-1.2	-0.8	-1.3
Ever highly irritable/argumentative for 2 days	1.5	1.9	6.7	0.6	1.4	0.4	-2.6	0.2
Loud music exposure frequency	1.0	1.1	4.3	0.7	0.4	0.4	-2.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.1	0.6	0.3	-1.0	0.4
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.8	-1.4	-0.1	-1.9	-0.9	-1.9
Blood clot in the leg (DVT)	1.6	2.0	4.5	-1.6	-0.0	-1.8	-0.1	-2.1
Medication: Paracetamol	0.7	1.2	5.2	-0.3	-0.1	0.7	2.3	0.6
Headache pain in last month	0.7	1.2	2.0	0.5	0.1	1.4	1.4	1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	0.1	0.4	1.2	1.1	1.1
Glaucoma (self-reported)	0.3	0.3	1.1	-1.0	0.2	0.3	-0.5	0.5
Gout (self-reported)	0.2	0.3	0.5	0.5	0.4	-0.7	0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.3	0.0	0.4	0.2	1.1	-0.1
Medication: Amlodipine	0.7	1.0	1.6	-1.3	-1.0	-1.0	-0.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.1	-0.7	-0.5	-0.1	-0.7
Birth weight	0.3	0.6	1.1	-0.9	0.7	0.6	1.1	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.6	0.2	0.8	-0.1	1.1
High blood pressure (siblings)	0.6	0.8	2.5	0.1	0.9	-0.5	-1.6	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	2.7	-1.6	1.1	-0.1	-0.1	0.1
Body fat percentage	1.5	5.8	25.1	1.1	-5.0	-0.4	1.4	-0.8
Leg fat percentage (right)	1.4	5.2	21.6	1.4	-4.6	-0.3	1.2	-0.8
Arm fat-free mass (right)	0.2	0.8	2.4	1.6	0.9	-0.3	-0.6	-0.7
Exposure to tobacco smoke outside home	1.3	1.8	7.0	-0.6	-2.6	0.6	0.9	0.4
Comparative body size at age 10	0.0	0.1	0.3	-0.5	-0.6	-0.2	-0.1	-0.1
Number of full brothers	1.0	1.3	2.7	-0.8	-1.6	0.6	1.6	0.4
Worry too long after embarrassment	1.6	2.7	8.6	-1.4	-2.9	0.9	0.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.0	0.1	-0.2	-0.1	-1.0	-0.4
Wheeze or whistling in the chest in last year	1.1	1.9	4.3	0.8	0.3	-1.8	-1.1	-2.1
Number of children fathered	0.9	1.1	3.8	-0.0	0.5	0.4	2.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.8	-0.8	-1.9	-0.5	0.3	-0.3
Age at first live birth	1.3	2.3	9.6	-1.1	0.8	-0.1	-3.1	0.2
Pulse wave peak to peak time	0.9	1.0	2.0	-0.4	0.8	1.4	0.4	1.4
Health satisfaction	0.6	0.8	1.3	0.9	-0.5	-0.8	1.2	-0.9
Shortness of breath walking on level ground	0.6	0.7	1.4	-0.8	-1.2	-0.6	0.5	-0.9
Qualifications: College or University degree	0.7	2.2	3.8	-2.0	0.6	1.2	-1.9	1.3
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.4	-0.2	-0.8	-0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	-0.7	-1.1	0.7	-1.2	0.1
Emphysema/chronic bronchitis	1.5	1.7	5.3	-2.3	-1.4	-0.2	0.9	-0.3
Medication for pain relief, constipation, heartburn	1.9	3.2	9.5	-1.2	-0.5	-1.6	-3.1	-1.6
Neck or shoulder pain in last month	0.9	1.3	5.2	0.7	2.3	-0.3	0.6	-0.4
Medication: Blood pressure	0.5	0.9	1.3	-0.6	-1.1	-1.1	-0.7	-1.1
Angina (self-reported)	0.6	0.8	1.4	-0.6	0.5	-1.2	-0.6	-1.2
Migraine (self-reported)	1.1	1.4	2.4	-1.0	0.4	-1.5	-1.0	-1.6
Medication: Ibuprofen	0.4	0.5	2.0	-0.2	-0.5	-0.1	1.4	0.0
Medication: Allopurinol	0.5	0.7	2.2	0.4	1.1	0.2	1.5	-0.0
Medication: Omeprazole	0.4	0.4	1.3	0.6	1.1	0.2	0.8	0.1
Medication: Seretide 50 evohaler	0.8	0.9	2.8	-1.1	-1.7	-0.1	0.7	-0.5
Mean time to correctly identify matches	1.9	3.6	6.5	-1.4	-1.7	-1.6	-2.5	-2.0
Heart disease (mother)	0.6	0.7	1.5	0.9	0.1	-1.2	-0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.4	0.3	1.5	1.2	-1.3	0.9
Whole body fat mass	0.9	3.9	16.5	1.4	-4.1	-0.3	0.7	-0.9
Leg fat mass (right)	1.0	3.8	15.5	1.5	-3.9	-0.3	0.4	-0.8
Arm predicted mass (right)	0.1	0.7	2.1	1.5	0.8	-0.2	-0.4	-0.6
Pulse rate, automated reading	0.1	0.4	0.8	0.0	0.6	0.7	-0.9	0.7
Alcohol intake frequency.	0.5	1.3	2.1	0.2	-0.7	1.3	1.4	1.4
Comparative height size at age 10	0.8	4.3	10.4	-0.2	1.3	3.2	-0.1	3.1
Number of full sisters	0.9	1.1	2.8	1.7	0.9	0.9	0.7	0.8
Suffer from ‘nerves’	0.7	1.1	2.0	-1.0	0.4	-1.0	1.4	-1.1
Overall health rating	1.3	2.8	4.0	1.4	-1.8	-1.3	2.0	-1.7
Chest pain or discomfort	2.0	2.8	5.1	-0.0	0.1	-2.2	-2.0	-2.3
Had major operations	1.2	1.4	2.2	-1.2	-0.6	1.1	1.5	1.3
Age at last live birth	0.8	1.1	3.8	-1.0	-0.3	-0.6	-2.0	-0.5
Family relationship satisfaction	1.7	2.1	5.2	1.5	0.7	-1.1	-2.3	-1.2
Leg pain on walking	0.3	0.3	0.5	0.7	-0.2	-0.7	-0.6	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.2	-0.7	1.5	-1.5	0.9	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	-0.3	-0.7	-0.4	1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.9	-0.5	1.0	-1.1	-1.3	-1.4
Medication: Aspirin	0.4	0.6	2.3	1.5	0.5	0.4	-0.1	0.4
Supplements: Vitamin C	0.2	0.3	0.7	0.0	-0.8	-0.7	-0.0	-0.6
Knee pain experienced in last month	0.8	1.2	2.0	-0.4	-1.3	1.2	1.4	1.0
Hypertension (Self-reported)	0.6	1.7	3.2	-1.3	-0.9	-1.8	-0.4	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	4.8	-0.2	2.0	2.1	0.4	2.2
Illnesses of father: Heart disease	0.5	0.7	3.0	1.7	-0.6	-0.4	0.4	-0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.3	0.7	0.4	1.1	0.3	1.1
Smoking status: Previous	0.1	0.1	0.2	0.0	0.2	0.4	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	6.2	-1.2	2.5	-0.3	0.2	-0.1
Whole body fat-free mass	0.1	0.7	2.1	1.4	1.0	0.1	-0.5	-0.4
Leg fat-free mass (right)	0.1	0.4	1.1	1.0	-0.2	-0.2	-0.6	-0.7
Arm fat percentage (left)	1.7	7.0	27.8	1.4	-5.3	-0.8	1.7	-1.3
Average weekly red wine intake	0.3	0.4	1.7	-1.3	0.2	-0.5	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	1.7	2.0	9.1	-0.8	-3.0	0.3	0.5	-0.0
Mood swings	0.3	0.6	1.0	-1.0	0.7	0.9	0.1	0.8
Loneliness, isolation	0.3	0.4	1.4	0.5	-0.4	0.3	-1.2	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.8	0.1	0.9	0.2	0.0	-0.1
Ever had bowel cancer screening	0.8	0.9	1.6	0.3	-1.2	-1.2	-0.3	-1.2
Diabetes diagnosed by doctor	1.2	2.0	4.9	0.9	-0.2	2.0	-0.6	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.8	-0.9	1.3	1.7	-0.7	1.6
Friendships satisfaction	0.7	0.9	3.6	0.7	0.4	-0.1	-1.9	-0.3
Qualifications: nursing, teaching	0.1	0.1	0.7	0.0	0.8	0.1	-0.1	0.1
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.2	-0.1	-0.7	0.1	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.8	-0.4	0.2	-0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.3	-1.7	-1.4	-0.7	1.8	-0.9
Medication for cholesterol	0.4	0.5	1.0	-0.5	0.8	0.9	0.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	12.8	0.2	0.5	0.1	3.6	0.4
Back pain experienced in last month	0.3	0.4	0.7	-0.7	-0.3	0.8	0.6	0.5
Mineral and other dietary supplements	0.4	0.6	1.6	1.0	-1.3	0.1	0.3	0.3
Breast cancer (self-reported)	1.6	1.9	6.4	-1.8	2.5	-0.3	-0.2	0.1
Asthma (self-reported)	0.4	0.7	1.7	1.3	1.2	-0.4	-0.0	-0.5
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.1	1.5	-0.4	-0.5	-0.4
Osteoarthritis (self-reported)	1.0	1.3	2.1	0.4	-0.9	1.5	1.5	1.1
Medication: Aspirin	0.2	0.3	1.3	1.1	0.2	-0.0	-0.2	-0.1
Medication: Gliclazide	0.5	0.6	1.2	1.1	0.4	0.7	0.4	1.0
Illnesses of father: None of the above (group 1)	2.3	2.8	5.0	0.3	1.8	2.2	1.0	2.1
Smoking status: Current	0.4	0.6	2.1	-0.2	0.8	0.2	-1.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.7	-0.3	-0.3	-0.5	-0.2
Whole body water mass	0.1	0.7	2.2	1.5	1.1	0.2	-0.5	-0.2
Leg predicted mass (right)	0.1	0.4	1.1	1.1	-0.1	-0.2	-0.6	-0.7
Arm fat mass (left)	1.1	4.6	16.8	1.7	-4.1	-0.8	0.9	-1.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.0	-0.3	0.3	1.0	1.0	0.8
Average weekly champagne plus white wine intake	0.5	0.7	2.3	-0.7	1.5	-0.4	-0.9	-0.1
Miserableness	0.4	0.7	1.4	-0.6	0.8	0.9	-0.3	1.2
Guilty feelings	0.1	0.1	0.3	-0.6	0.1	-0.3	-0.1	-0.2
Wears glasses or contact lenses	0.5	0.6	1.0	0.9	1.0	0.7	0.3	0.7
Ever taken oral contraceptive pill	0.5	0.5	1.8	0.2	-0.1	-0.6	1.3	-0.6
Hearing aid user	2.5	2.8	6.8	-2.1	-1.1	1.0	2.6	0.9
Mother’s age at death	1.0	1.2	5.1	-2.2	0.1	-0.7	-0.2	-0.7
Financial situation satisfaction	0.5	0.6	1.8	-0.6	-1.4	-0.2	-0.8	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.8	1.3	0.7	-0.3	0.4
Commuting to job workplace: Public transport	0.4	0.5	1.6	0.5	-1.2	0.5	-0.7	0.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-0.3	0.3	-0.6	-1.3	-0.5
Medication: Blood pressure	0.6	1.2	2.2	-1.5	-1.2	-1.0	0.2	-1.1
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.2	0.5	1.1	2.0	1.7	2.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	-0.8	0.9	-0.6	0.5	-0.8
High cholesterol (Self-reported)	1.5	2.6	6.6	-0.6	-0.2	-2.5	0.1	-2.6
Medication: Bendroflumethiazide	0.7	1.1	3.4	0.0	-0.3	-1.3	-0.1	-1.8
Medication: Paracetamol	0.7	1.1	3.7	-0.7	-0.1	0.9	1.9	0.9
Medication: Lisinopril	1.1	1.4	3.5	-0.3	-1.7	0.4	1.9	0.5
Medication: Atorvastatin	0.3	0.4	0.9	0.5	0.4	-0.5	-1.0	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.2	-1.1	0.4	-0.5	-0.6	-0.5
Alcohol drinker status: Never	0.5	0.6	1.4	-0.4	0.6	0.8	-1.2	0.6
Ever smoked	0.1	0.2	0.7	-0.4	0.0	-0.2	-0.5	-0.8
Basal metabolic rate	0.1	0.4	1.9	1.4	0.2	0.0	-0.2	-0.5
Leg fat percentage (left)	1.3	4.8	19.9	1.4	-4.5	-0.1	1.3	-0.6
Arm fat-free mass (left)	0.1	0.5	1.8	1.3	0.4	0.0	-0.5	-0.5
Number of operations (self-reported)	0.4	0.6	1.5	0.4	0.9	0.7	1.2	0.5
Average weekly beer plus cider intake	0.3	0.5	1.8	-0.2	-0.5	0.4	1.3	0.3
Irritability	0.7	1.1	3.9	0.1	1.3	0.2	-2.0	0.3
Risk taking	0.5	0.7	1.5	1.2	0.5	0.5	-1.1	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.1	0.3
Fractured/broken bones in last 5 years	1.7	2.2	5.4	-0.6	-1.1	1.5	-2.3	1.4
Age started oral contraceptive pill	1.4	1.8	4.0	2.0	-1.5	-0.9	-1.3	-0.4
Diastolic blood pressure, automated reading	0.6	2.0	7.5	1.5	-0.1	-0.4	-2.7	0.0
Ever depressed for a whole week	1.1	1.4	4.8	2.2	0.7	-0.2	-1.2	-0.2
Unable to work because of sickness or disability	0.8	1.1	4.3	2.1	0.7	-0.4	-0.1	-0.6
Commuting to job workplace: Cycle	0.7	0.9	2.2	-1.5	1.3	0.5	0.3	0.4
Myopia	3.2	4.7	8.3	0.9	2.4	2.9	0.4	2.9
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.1	1.1	1.0	1.8	0.8	1.8
Cholesterol lowering medication	0.5	0.7	1.2	0.4	-0.4	-1.1	0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.1	1.4	2.0	0.9	0.9	1.0
Pain experienced in last month	1.0	1.7	4.4	-1.0	-0.4	-1.2	-2.1	-1.2
Supplements: Calcium	2.0	2.2	4.7	-2.2	1.4	-1.1	-1.4	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	0.3	0.8	0.2	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.8	0.9	0.4	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	4.2	-1.6	-0.3	-1.7	-0.2	-2.0
Heart disease (siblings)	1.0	1.3	2.4	-1.4	-0.7	-1.3	-0.3	-1.5
Alcohol drinker status: Previous	0.7	0.9	2.2	-1.5	-0.0	-0.7	1.0	-0.7
Pack years of smoking	0.2	0.2	0.3	-0.5	-0.5	-0.2	0.6	-0.5
Impedance of whole body	0.4	1.9	3.4	-1.6	-0.9	1.5	0.7	1.9
Leg fat mass (left)	0.9	3.7	15.4	1.5	-3.9	-0.2	0.4	-0.8
Arm predicted mass (left)	0.1	0.4	1.6	1.3	0.6	0.1	-0.2	-0.4