TWAS hub - CCDC148

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.182	0.0430	2.8e-06	0.023	0.069	0.073	0.082	0.030	6.8e-04	8.5e-09	3.2e-09	3.2e-10	1.3e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.167	0.0417	3.9e-09	0.079	0.063	0.049	0.062	0.073	2.4e-10	1.7e-08	5.5e-07	1.9e-08	1.0e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Diastolic blood pressure, automated reading	9.2	28.4	40.1	-4.1	-6.3
High blood pressure (siblings)	6.4	9.2	13.1	-2.3	-3.6
Leg pain on walking	6.1	7.7	13.9	-1.2	-3.7
Systolic blood pressure, automated reading	5.8	16.8	26.4	-2.7	-5.1
Illnesses of siblings	5.8	8.2	12.6	1.9	3.5
High blood pressure	5.6	15.6	25.6	-2.4	-5.1
Medication: Atenolol	5.4	6.8	7.5	-2.5	-2.7
Noisy workplace	5.3	6.5	11.6	-1.2	-3.4
Hypertension (Self-reported)	5.1	14.3	22.1	-2.5	-4.7
Vascular/heart problems diagnosed by doctor	5.1	14.0	23.8	2.0	4.9
Cardiovascular Disease	5.0	16.6	22.1	-3.3	-4.7
Medication for cholesterol, blood pressure or diabetes	4.6	7.7	14.7	0.8	3.8
Number of treatments/medications taken	4.5	8.0	15.0	-1.0	-3.9
Long-standing illness, disability or infirmity	4.5	7.0	9.2	-2.2	-3.0
Illness, injury, bereavement, stress in last 2 years	4.3	5.3	5.3	2.3	2.3
Diabetes diagnosed by doctor	4.3	7.1	8.7	-2.3	-2.9
Number of self-reported non-cancer illnesses	4.1	7.0	8.2	-2.4	-2.9
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.6	10.7	-1.6	-3.3
Diabetes (self-reported)	3.9	6.0	8.2	-1.9	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.9	5.1	9.9	-3.1	-0.5
Schizophrenia vs Biploar Disorder	3.7	4.8	4.9	2.2	2.2
Serious illness, injury or assault to yourself	3.7	4.5	5.7	-2.4	-1.8
Leg fat percentage (right)	3.7	13.3	20.8	-2.4	-4.6
Pulse wave peak to peak time	3.7	4.3	6.4	2.5	1.5
Qualifications: College or University degree	3.6	11.2	18.3	2.0	4.3
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.3	4.4	-2.1	-2.0
Myopia	3.6	5.3	10.5	0.1	3.2
Systolic Blood Pressure	3.5	17.7	25.5	-3.1	-5.0
Medication for hormone replacement therapy	3.5	3.9	7.0	2.6	0.9
Average weekly spirits intake	3.4	4.2	6.1	-1.6	-2.5
Medication: Blood pressure	3.4	5.9	11.2	-0.8	-3.3
Arm fat percentage (left)	3.4	13.7	22.2	-2.3	-4.7
Medication: Atorvastatin	3.4	4.2	8.4	-0.1	-2.9
Waist circumference	3.3	12.1	19.1	-2.3	-4.4
Arm fat percentage (right)	3.3	12.8	22.1	-1.9	-4.7
Leg fat percentage (left)	3.3	12.0	20.0	-2.0	-4.5
Body fat percentage	3.2	12.7	21.5	-2.0	-4.6
Had major operations	3.2	3.7	4.2	-1.8	-2.0
Unable to work because of sickness or disability	3.2	4.1	6.3	-2.5	-1.4
Schizophrenia (2014)	3.1	6.9	7.3	2.5	2.7
Body mass index (BMI)	3.1	13.2	18.9	-2.8	-4.3
Mood swings	3.1	5.6	7.4	-2.7	-2.0
Wears glasses or contact lenses	3.1	3.6	6.2	-1.0	-2.5
Number of operations (self-reported)	3.0	4.5	4.7	-2.2	-2.1
Neuroticism (2016)	2.9	4.2	6.3	-2.5	-1.4
Leg fat mass (right)	2.9	11.2	16.6	-2.4	-4.1
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	5.8	0.7	2.4
Hearing difficulty/problems with background noise	2.8	4.4	6.7	2.6	1.5
Pulse rate	2.8	4.8	5.4	-2.3	-2.0
Ever smoked	2.8	5.0	7.6	1.5	2.8
Leg fat mass (left)	2.8	10.8	16.6	-2.2	-4.1
Taking other prescription medications	2.7	4.2	5.9	-1.6	-2.4
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.3	-0.5	-2.5
Pulse wave Arterial Stiffness index	2.7	3.2	5.3	-2.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	3.9	1.5	2.0
Whole body fat mass	2.7	11.3	18.1	-2.1	-4.3
Arm fat mass (left)	2.7	11.3	17.8	-2.2	-4.2
Hearing difficulty/problems: Yes	2.6	4.0	6.0	2.5	1.4
Trunk fat percentage	2.6	10.2	18.2	-1.5	-4.3
Maternal smoking around birth	2.6	3.7	7.3	0.4	2.7
Body Mass Index (BMI) (2010)	2.5	3.5	4.7	-1.5	-2.2
Worrier / anxious feelings	2.5	4.7	5.9	-2.4	-1.9
Miserableness	2.5	4.3	4.7	-2.2	-2.0
Medication: Cholesterol lowering	2.4	3.8	7.5	-0.2	-2.7
Arm fat mass (right)	2.4	9.8	16.6	-1.8	-4.1
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	5.0	-0.9	-2.2
Type 2 Diabetes (T2D) (2018)	2.3	4.2	6.6	-1.4	-2.6
Fluid intelligence score	2.3	4.8	5.3	2.1	2.3
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	3.4	-1.8	-1.4
Medication: Omeprazole	2.3	2.8	4.7	-0.9	-2.2
Medication: Blood pressure	2.3	4.3	7.7	-1.0	-2.8
Shortness of breath walking on level ground	2.2	2.6	4.7	-0.8	-2.2
Mouth/teeth dental problems: Mouth ulcers	2.2	3.4	6.0	-0.9	-2.5
Medication: Bendroflumethiazide	2.2	3.3	5.9	-0.8	-2.4
Medication: Metformin	2.1	3.0	4.4	-1.3	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	4.8	-1.3	-2.2
Overall health rating	2.1	4.5	7.4	-1.3	-2.7
Knee pain experienced in last month	2.1	3.2	4.6	-1.4	-2.1
Average weekly red wine intake	2.1	3.0	3.3	1.7	1.8
Guilty feelings	2.1	3.1	3.7	-1.6	-1.9
Cholesterol lowering medication	2.1	3.1	5.3	-1.0	-2.3
Pain experienced in last month	2.1	3.5	6.1	0.9	2.5
High blood pressure (mother)	2.0	2.9	3.0	-1.6	-1.7
Trunk fat mass	2.0	8.6	14.8	-1.5	-3.9
Past tobacco smoking	2.0	3.7	4.1	-2.0	-1.8
Tinnitus: Yes, now most or all of the time	2.0	2.4	4.8	-0.1	-2.2
Hip circumference	1.9	8.0	13.1	-1.7	-3.6
Number of full sisters	1.9	2.3	4.2	-0.7	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	4.1	-0.7	-2.0
Schizophrenia (2018)	1.8	3.7	5.5	1.4	2.4
BMI	1.8	10.4	13.8	-2.7	-3.7
Qualifications: CSEs or equivalent	1.8	2.3	3.5	-1.9	-1.1
Health satisfaction	1.8	2.4	4.5	0.5	-2.1
Alcohol intake frequency.	1.8	4.3	4.5	-2.1	-2.0
Friendships satisfaction	1.8	2.3	4.3	2.1	0.5
High cholesterol (Self-reported)	1.8	3.3	5.7	-0.9	-2.4
Fractured/broken bones in last 5 years	1.8	2.4	3.3	1.2	1.8
Number of live births	1.7	2.3	4.0	-0.9	-2.0
Emphysema/chronic bronchitis	1.7	1.9	2.3	1.5	1.2
Family relationship satisfaction	1.7	2.1	3.2	1.0	1.8
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.0	-2.0	-0.6
Blood clot in the leg (DVT)	1.6	2.1	3.8	-1.9	-0.6
Pulse rate, automated reading	1.6	5.1	5.6	-2.1	-2.4
Medication: Aspirin	1.6	2.1	4.1	-0.2	-2.0
Ever had bowel cancer screening	1.6	1.8	2.5	1.1	1.6
Illnesses of father: High blood pressure	1.6	2.0	2.8	-1.0	-1.7
Bipolar Disorder (2011)	1.5	1.4	2.8	0.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.4	-0.7	-1.9
Exposure to tobacco smoke at home	1.5	1.7	2.4	1.0	1.6
Ever depressed for a whole week	1.5	1.8	3.6	-0.1	-1.9
Alcohol drinker status: Previous	1.5	1.8	2.4	-1.1	-1.6
Neuroticism (Nagel 2018)	1.4	3.2	4.3	-2.1	-1.5
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.8	-0.6	-1.7
Smoking Status	1.4	3.4	5.9	0.9	2.4
Supplements: Zinc	1.4	1.5	1.7	-1.2	1.3
Medication: Simvastatin	1.4	2.1	4.1	-0.2	-2.0
Neuroticism score	1.4	2.9	4.5	-2.1	-1.1
Depression (self-reported)	1.4	1.7	3.2	-1.8	-0.4
Illnesses of mother	1.4	1.7	2.2	1.1	1.5
Neck or shoulder pain in last month	1.4	2.0	3.8	-0.4	-1.9
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.4	-0.9	-1.6
Commuting to job workplace: Walk	1.4	1.5	2.0	-1.4	1.0
Medication for cholesterol	1.4	2.1	4.1	0.2	2.0
Average weekly beer plus cider intake	1.4	2.1	2.5	1.3	1.6
Irritability	1.4	2.3	3.4	-1.8	-1.1
Prostate Cancer	1.3	1.8	3.5	0.0	-1.9
Diabetes (father)	1.3	1.6	1.9	-1.2	-1.4
Fed-up feelings	1.3	2.3	3.6	-1.9	-1.0
Mouth/teeth dental problems	1.3	2.0	3.1	0.9	1.8
Pain all over the body in last month	1.3	1.3	1.9	-1.4	-0.9
Bipolar Disorder or Schizophrenia	1.2	3.0	4.8	1.1	2.2
Depressed Affect (Nagel 2018)	1.2	2.6	4.1	-2.0	-1.1
Financial difficulties in last 2 years	1.2	1.6	2.2	-1.5	-1.0
Happiness	1.2	1.5	2.1	1.5	0.9
Birth weight of first child	1.2	2.2	4.4	-0.2	2.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.9	-1.7	-0.9
Medication: Amlodipine	1.2	1.7	3.1	-0.6	-1.8
Illnesses of siblings: Diabetes	1.2	1.5	2.9	0.1	-1.7
Medication: Aspirin	1.2	1.6	3.2	-0.0	-1.8
Triglycerides	1.1	1.8	2.6	-1.0	-1.6
Lung FEV1/FVC ratio	1.1	5.7	7.7	-1.9	-2.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.4	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.8	0.5	2.2
Supplements: Vitamin C	1.1	1.4	2.3	-0.6	1.5
Smoking status: Previous	1.1	1.6	2.8	1.7	0.7
Smoking status: Current	1.1	1.7	3.0	-0.6	1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.0	1.4	0.8
Medication: Co-codamol	1.0	1.1	1.3	-1.0	-1.1
Weight	1.0	4.9	7.7	-1.4	-2.8
Birth weight	1.0	2.1	2.6	1.3	1.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	-1.5	-0.1
Eye problems/disorders: None of the above	1.0	1.2	1.8	-0.7	1.4
Breast cancer (self-reported)	1.0	1.1	1.3	-1.1	-1.0
Risk taking	1.0	1.4	2.8	0.2	1.7
Alzheimer’s Disease (including proxy)	0.9	1.3	1.7	0.9	1.3
Rheumatoid Arthritis	0.9	1.3	2.6	0.1	1.6
Ulcerative Colitis	0.9	1.2	1.5	1.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.9	-0.7	-1.4
Current tobacco smoking	0.9	1.5	2.6	-0.7	1.6
Had other major operations	0.9	1.0	1.3	-0.9	-1.1
Forced vital capacity (FVC)	0.9	3.3	5.1	1.2	2.3
Loud music exposure frequency	0.9	1.0	1.5	1.2	-0.6
Headache pain in last month	0.9	1.5	2.5	-0.7	-1.6
Forced vital capacity (FVC), Best measure	0.9	3.3	5.4	1.1	2.3
Number of children fathered	0.9	1.0	1.5	-1.2	-0.7
Migraine (self-reported)	0.9	1.1	1.7	-1.3	-0.7
Loneliness, isolation	0.9	1.3	2.0	-0.7	1.4
Heart disease (siblings)	0.9	1.1	2.1	-0.1	-1.5
Intelligence (Savage-Jansen 2018)	0.8	2.3	2.9	1.3	1.7
Ovarian Cancer	0.8	1.1	1.1	1.0	1.0
Blood Red Count	0.8	7.4	9.7	-2.3	-3.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.8	-0.4	-1.3
Medication: Lansoprazole	0.8	0.9	1.6	1.3	-0.5
Alcohol drinker status: Never	0.8	0.9	1.5	1.2	0.6
Age at First Birth	0.7	1.0	1.4	-0.8	-1.2
HbA1C	0.7	0.8	0.8	-0.9	0.9
Relative age voice broke	0.7	1.0	1.6	-0.6	1.3
Medication: Levothyroxine sodium	0.7	1.2	2.2	-0.4	-1.5
Commuting to job workplace: Public transport	0.7	0.8	0.8	0.9	0.9
Supplements: Calcium	0.7	0.7	1.2	-0.5	1.1
Crohns Disease (2012)	0.6	1.0	1.4	1.2	0.8
Mean Putamen Volume	0.6	0.6	1.2	-1.1	-0.4
Fasting Glucose	0.6	0.7	1.3	-1.1	-0.4
Height	0.6	11.0	12.0	3.5	3.1
Vitamin and mineral supplements	0.6	0.9	1.0	0.8	-1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	1.1	-0.4
Impedance of arm (right)	0.6	2.7	4.5	2.1	1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	-1.6	-0.2
Standing height	0.6	5.8	6.7	2.2	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.7	-1.3	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.2	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.5	0.1	-1.2
Exposure to tobacco smoke outside home	0.6	0.8	1.5	-1.2	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	0.9	-0.6	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.5	0.1	-1.2
Financial situation satisfaction	0.6	0.7	1.2	1.1	-0.5
Ulcerative Colitis (UC)	0.5	0.9	0.9	0.9	0.9
Hand grip strength (left)	0.5	1.2	1.4	1.2	1.0
Townsend deprivation index at recruitment	0.5	0.7	0.7	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	0.6	1.4
Heart attack	0.5	0.7	1.1	0.4	-1.1
Medication: Ramipril	0.5	0.7	0.8	0.8	-0.9
Alcohol intake versus 10 years previously	0.5	0.8	1.2	-1.1	-0.6
Hair/balding pattern: Pattern 4	0.5	1.1	2.3	-0.1	1.5
Medication: Allopurinol	0.5	0.7	1.0	0.6	1.0
Comparative height size at age 10	0.5	2.6	5.1	2.2	0.4
Back pain experienced in last month	0.5	0.7	1.4	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.4	0.8	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.9	0.9	-0.4
Coronary Artery Disease (CAD)	0.4	0.5	0.8	0.3	0.9
LDL Cholesterol	0.4	0.7	1.3	-0.2	1.1
Lupus	0.4	0.6	1.1	0.0	-1.1
Primary Biliary Cirrhosis	0.4	0.5	1.1	0.0	1.0
Lung FVC	0.4	2.3	4.2	0.5	2.1
Neuroticism	0.4	1.0	1.9	-1.4	-0.3
Relative age of first facial hair	0.4	0.9	1.5	-0.4	1.2
Diabetes (mother)	0.4	0.5	0.8	0.9	0.4
Multivitamins +/- minerals	0.4	0.5	1.0	-0.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.0	-0.4	1.0
Lung cancer (father)	0.4	0.5	0.9	-0.9	-0.3
Breastfed as a baby	0.4	0.4	0.9	-0.1	0.9
Tense / ‘highly strung’	0.4	0.7	1.1	-0.7	1.0
Glaucoma (self-reported)	0.4	0.5	0.9	1.0	0.0
Arm fat-free mass (right)	0.4	2.0	2.5	-1.6	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	0.2	1.2
Age at last live birth	0.4	0.6	1.2	-1.1	-0.2
Mineral and other dietary supplements	0.4	0.5	0.8	0.9	0.5
Average weekly champagne plus white wine intake	0.4	0.6	0.6	0.7	0.8
Arm fat-free mass (left)	0.4	2.1	2.3	-1.4	-1.5
Commuting to job workplace: Cycle	0.4	0.5	0.6	0.8	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.9	0.5	-0.9
Arm predicted mass (left)	0.4	2.0	2.1	-1.4	-1.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.0	0.5	1.0
Reaction Time	0.3	0.6	1.1	0.3	1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.0	1.0	0.7
Waist Hip Ratio (WHR)	0.3	1.5	2.3	-1.5	-0.8
Angina	0.3	0.3	0.7	0.8	-0.1
Leg fat-free mass (left)	0.3	1.7	2.1	-1.5	-1.2
Leg predicted mass (left)	0.3	1.8	2.1	-1.5	-1.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	1.6	0.2	1.3
Impedance of arm (left)	0.3	1.4	2.1	1.5	0.8
Length of working week for main job	0.3	0.3	0.6	0.8	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	0.9	0.4
Age at first live birth	0.3	0.6	1.0	-1.0	-0.4
Angina (self-reported)	0.3	0.4	0.7	0.8	-0.2
Medication: Ibuprofen	0.3	0.4	0.6	-0.5	0.8
Mean time to correctly identify matches	0.3	0.6	0.7	0.9	0.6
Arm predicted mass (right)	0.3	1.3	2.1	-1.4	-0.8
Chest pain or discomfort	0.3	0.4	0.8	0.9	-0.2
Qualifications: nursing, teaching	0.3	0.4	0.8	0.3	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.5	0.7	-0.3
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.3	-0.9
Medication: Gliclazide	0.3	0.4	0.4	-0.6	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.8	-0.3
Medication: Lisinopril	0.3	0.4	0.8	0.2	-0.9
Basal metabolic rate	0.3	1.4	1.4	-1.2	-1.2
Worry (Nagel 2018)	0.2	0.5	0.8	-0.9	0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.1	0.7
Chronotype (morning person)	0.2	0.5	1.0	-1.0	0.4
Sensitivity / hurt feelings	0.2	0.4	0.5	-0.7	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.6	0.1
Impedance of leg (left)	0.2	1.1	1.9	1.4	0.6
Number of incorrect matches in round	0.2	0.3	0.6	0.8	0.2
Nervous feelings	0.2	0.4	0.6	-0.5	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	0.5	0.6
Falls in the last year	0.2	0.3	0.6	-0.8	-0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	0.2	0.8
Number of full brothers	0.2	0.2	0.4	0.6	0.0
Worry too long after embarrassment	0.2	0.3	0.5	0.0	-0.7
Suffer from ‘nerves’	0.2	0.3	0.5	-0.4	0.7
Leg fat-free mass (right)	0.2	1.0	1.1	-1.0	-0.9
Leg predicted mass (right)	0.2	0.8	1.0	-1.0	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.3	0.5	0.6
Medication: Paracetamol	0.2	0.2	0.5	0.1	0.7
Impedance of whole body	0.2	1.2	1.9	1.4	0.7
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.0	0.6
Major Depression (MDD)	0.1	0.1	0.2	-0.2	-0.4
HDL Cholesterol	0.1	0.2	0.2	-0.4	0.4
Blood Eosinophil Count	0.1	0.6	1.1	0.4	-1.1
Blood Platelet Count	0.1	0.8	1.5	-0.1	-1.2
Heel T-Score	0.1	0.9	1.8	0.3	1.3
Allergy or Eczema	0.1	0.1	0.2	0.5	-0.3
Hypothyroidism (self reported)	0.1	0.2	0.3	0.1	-0.6
Tanning	0.1	1.1	2.1	-0.2	1.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	-0.1
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.5
Pack years adult smoking proportion	0.1	0.1	0.1	0.3	0.4
Impedance of leg (right)	0.1	0.5	0.6	0.7	0.8
Hand grip strength (right)	0.1	0.4	0.7	0.8	0.3
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	0.4
Age when periods started (menarche)	0.1	0.2	0.4	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.7	0.2
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.3	-0.4
Supplements: Glucosamine	0.1	0.1	0.2	0.4	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.5
Had menopause	0.1	0.2	0.2	0.4	0.4
Qualifications: None of the above	0.1	0.2	0.4	0.6	-0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.6	0.2
Time employed in main current job	0.1	0.2	0.2	0.4	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.3	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.1	0.5
Prospective memory result	0.1	0.1	0.1	0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	-0.1	0.9
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.1	0.7
Medication: Paracetamol	0.1	0.2	0.3	-0.1	0.6
Gout (self-reported)	0.1	0.1	0.2	-0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.5	-0.4
Comparative body size at age 10	0.1	0.2	0.2	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.5	0.3
Whole body fat-free mass	0.1	0.6	0.8	-0.9	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.2	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	0.1	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.2	-0.3
Whole body water mass	0.1	0.7	0.9	-1.0	-0.7
Hearing aid user	0.1	0.2	0.3	-0.6	-0.0
Mother’s age at death	0.1	0.1	0.2	0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.4	0.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.2	-0.4
Pack years of smoking	0.1	0.1	0.2	0.5	0.1
Depression (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.0	-0.2
Crohns Disease (2017)	0.0	0.1	0.2	-0.1	0.4
Breast Cancer	0.0	0.1	0.2	0.2	-0.4
Blood White Count	0.0	0.3	0.4	-0.4	-0.6
Respiratory disease	0.0	0.1	0.1	0.3	-0.2
Hair Pigment	0.0	0.6	0.9	0.9	0.6
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.3	-0.0
Sitting height	0.0	0.1	0.2	0.2	-0.5
Alcohol usually taken with meals	0.0	0.0	0.0	0.0	-0.0
Allergy	0.0	0.0	0.0	-0.2	0.0
Trunk fat-free mass	0.0	0.2	0.3	-0.6	-0.0
Father’s age at death	0.0	0.0	0.0	-0.0	0.1
Asthma	0.0	0.0	0.0	0.0	-0.2
Trunk predicted mass	0.0	0.2	0.4	-0.6	-0.0
Pulse wave reflection index	0.0	0.0	0.0	-0.1	0.0
Heart disease (mother)	0.0	0.1	0.1	-0.1	-0.3
Illnesses of father: Heart disease	0.0	0.0	0.1	0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.1	-0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.2	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	-0.0
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.0	0.1

Hub : Genes

CCDC148

Models

Trait associations