Hub : Genes

CCDC25

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1820 0.0430 2.7e-11 0.091 0.126 0.100 0.127 0.108 3.8e-11 4.7e-15 3.2e-12 3.2e-15 4.5e-13
2 GTEx Artery Aorta 0.1530 0.0480 1.8e-04 0.163 NA 0.118 NA 0.132 2.7e-09 NA 4.9e-07 NA 9.5e-08
3 GTEx Brain Caudate basal ganglia 0.3260 0.0800 2.0e-05 0.241 NA 0.047 NA 0.193 1.5e-07 NA 1.8e-02 NA 3.3e-06
4 GTEx Brain Cerebellar Hemisphere 0.6160 0.0900 4.1e-08 0.338 NA 0.219 NA 0.234 1.7e-09 NA 2.6e-06 NA 1.1e-06
5 GTEx Brain Cerebellum 0.4250 0.0760 4.3e-09 0.419 NA 0.304 NA -0.010 1.2e-13 NA 1.2e-09 NA 9.7e-01
6 GTEx Brain Frontal Cortex BA9 0.2880 0.0933 1.0e-03 0.095 NA 0.068 NA 0.078 1.8e-03 NA 7.4e-03 NA 4.2e-03
7 GTEx Brain Hippocampus 0.3639 0.1240 3.2e-03 0.036 NA 0.043 NA 0.080 5.1e-02 NA 3.6e-02 NA 6.4e-03
8 GTEx Brain Nucleus accumbens basal ganglia 0.2770 0.0740 8.7e-05 0.305 NA 0.229 NA 0.241 7.0e-09 NA 8.3e-07 NA 4.1e-07
9 GTEx Cells Transformed fibroblasts 0.2860 0.0530 1.0e-13 0.254 NA 0.296 NA 0.275 4.1e-19 NA 1.6e-22 NA 9.4e-21
10 GTEx Colon Transverse 0.2230 0.0650 2.4e-04 0.159 NA 0.187 NA 0.056 5.1e-08 NA 2.8e-09 NA 1.1e-03
11 GTEx Liver 0.4120 0.0870 1.5e-06 0.266 NA 0.213 NA 0.242 4.4e-08 NA 1.3e-06 NA 2.1e-07
12 GTEx Muscle Skeletal 0.1738 0.0356 5.6e-10 0.145 NA 0.128 NA 0.145 4.5e-14 NA 1.7e-12 NA 4.0e-14
13 GTEx Nerve Tibial 0.3008 0.0482 3.3e-16 0.246 NA 0.263 NA 0.277 1.7e-17 NA 1.1e-18 NA 8.9e-20
14 GTEx Pancreas 0.2600 0.0620 4.9e-06 0.186 NA 0.143 NA 0.033 2.6e-08 NA 1.3e-06 NA 1.5e-02
15 GTEx Testis 0.1910 0.0640 5.3e-04 0.129 NA 0.081 NA 0.115 2.6e-06 NA 1.8e-04 NA 8.7e-06
16 ROSMAP Brain Pre-frontal Cortex 0.1521 0.0295 1.1e-16 0.183 0.121 0.180 -0.002 -0.002 6.5e-23 2.5e-15 1.3e-22 6.5e-01 6.9e-01
17 YFS Blood 0.0665 0.0132 0.0e+00 0.080 0.081 0.080 0.084 0.085 6.8e-25 3.1e-25 8.7e-25 3.2e-26 2.8e-26
18 TCGA Glioblastoma Multiforme 0.1250 0.0700 1.7e-03 0.063 0.086 0.101 NA 0.077 5.6e-03 1.4e-03 5.5e-04 NA 2.5e-03
19 TCGA Brain Lower Grade Glioma 0.1272 0.0484 1.0e-13 0.081 0.121 0.120 NA 0.128 1.9e-09 1.4e-13 1.5e-13 NA 2.2e-14
20 TCGA Pheochromocytoma and Paraganglioma 0.1650 0.0660 1.0e-05 0.125 0.133 0.116 NA 0.107 1.2e-05 5.9e-06 2.5e-05 NA 4.9e-05
21 TCGA Soft Tissue Sarcoma 0.0640 0.0420 8.8e-03 -0.002 0.036 0.010 NA 0.002 4.2e-01 3.2e-03 7.5e-02 NA 2.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bipolar Disorder (2018) 3.4 5.4 10.2 -1.9 -2.2 -2.6 -2.1 -2.4 -1.5 -0.1 -2.5 -3.2 2.4 2.6 2.6 -2.9 2.0 -2.0 -2.4 -2.6 -2.0 -2.2 -2.8 -1.9
Bipolar Disorder or Schizophrenia 4.5 11.0 16.0 -2.9 -3.5 -3.7 -2.0 -3.8 -2.5 -1.5 -3.6 -3.2 3.3 3.7 3.7 -4.0 3.2 -3.3 -3.6 -3.6 -3.3 -3.5 -4.0 -2.4
Depressed Affect (Nagel 2018) 0.9 1.9 3.3 1.3 1.4 1.4 0.6 1.4 1.8 1.7 1.5 0.8 -1.5 -1.5 -1.5 1.1 -1.7 1.3 1.0 0.4 1.0 1.4 1.3 1.8
Depression (Nagel 2018) 1.6 2.5 5.8 1.2 1.2 1.6 1.2 1.7 1.5 1.9 1.6 1.8 -1.1 -1.6 -1.6 1.5 -2.4 1.2 1.6 1.1 1.5 1.3 1.6 1.9
Intelligence (Savage-Jansen 2018) 0.3 1.0 3.5 -0.9 -0.4 -1.0 -0.3 -1.0 -1.0 1.8 -0.8 -0.3 0.8 1.0 1.1 -0.5 1.9 -0.5 -1.1 -0.4 -1.6 -0.6 -1.0 -1.2
Neuroticism (Nagel 2018) 0.2 0.4 1.2 0.0 0.5 0.8 0.9 0.6 1.1 0.8 0.8 0.4 -0.8 -0.8 -0.8 0.4 -0.7 0.6 0.4 0.3 0.4 0.4 0.2 0.7
Schizophrenia (2018) 2.9 5.9 8.8 -2.2 -2.8 -2.7 -0.8 -3.0 -2.0 -2.2 -2.6 -1.6 2.3 2.6 2.7 -2.8 2.4 -2.6 -2.6 -2.4 -2.6 -2.7 -2.9 -1.6
Schizophrenia vs Biploar Disorder 1.0 1.4 6.1 1.5 0.8 1.1 2.2 0.4 -1.1 0.6 1.0 1.0 -1.4 -0.9 -1.0 1.0 -0.7 0.3 1.0 0.9 0.3 0.9 1.4 2.5
Worry (Nagel 2018) 0.4 0.9 2.2 -1.3 -1.2 -0.8 -0.3 -1.0 0.1 -0.6 -0.8 -0.7 1.0 0.8 0.9 -1.2 0.8 -1.1 -0.9 -1.1 -1.4 -1.3 -1.5 -0.3
Alzheimer’s Disease (in mother) 3.6 4.2 8.1 -0.0 -2.7 -2.2 -2.1 -1.9 -1.7 -0.8 -2.2 -2.8 1.8 2.1 2.1 -2.3 1.0 -2.6 -2.2 -2.3 -2.6 -1.9 -2.4 -0.6
Alzheimer’s Disease (in father) 1.5 1.6 4.2 -1.7 -0.9 -1.3 -2.0 -1.3 -0.7 -0.5 -1.2 -1.4 1.2 1.3 1.3 -1.2 0.6 -0.7 -1.5 -1.5 -1.1 -1.7 -1.6 -1.1
Alzheimer’s Disease (including proxy) 4.9 7.0 13.8 -1.2 -3.0 -2.7 -2.8 -2.6 -1.8 -1.2 -2.7 -3.7 2.4 2.7 2.7 -2.7 1.6 -2.5 -3.0 -3.1 -3.4 -2.9 -3.4 -1.6
Crohns Disease (2017) 1.3 2.9 4.3 -1.2 -1.7 -1.9 -1.4 -1.9 -0.7 -1.5 -2.0 -0.9 1.4 2.0 2.1 -1.8 1.7 -1.8 -2.1 -1.9 -1.9 -1.9 -1.8 -1.2
Irritable Bowel Disease (IBD) 1.1 2.6 4.4 -1.4 -1.5 -1.9 -1.6 -1.6 -0.4 -0.8 -1.8 -0.5 1.3 1.9 1.9 -1.7 1.4 -1.4 -2.1 -1.9 -1.7 -1.8 -1.9 -1.8
Ulcerative Colitis (UC) 0.5 0.9 3.2 -1.4 -0.6 -1.0 -0.9 -0.7 0.4 0.1 -0.8 0.3 0.3 1.0 1.0 -0.8 0.9 -0.4 -1.3 -1.1 -0.9 -0.9 -1.2 -1.8
Major Depression (MDD) 0.4 0.5 2.3 -0.2 -0.5 -0.5 -0.4 -0.9 -1.0 -1.3 -0.7 -0.3 0.0 0.6 0.6 -0.6 1.1 -0.7 -0.6 -0.1 -1.5 -0.2 -0.5 -0.5
Reaction Time 1.9 3.6 7.2 -2.1 -1.9 -1.9 -1.2 -2.3 -1.2 -0.7 -1.8 -1.9 1.5 1.8 1.8 -2.3 1.4 -1.8 -1.9 -2.4 -1.7 -2.7 -2.1 -2.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 2.0 -0.2 -0.2 -0.6 -0.2 -0.6 -0.1 0.6 -0.5 -0.7 0.1 0.6 0.7 -0.2 1.4 -0.4 -0.6 -0.4 -1.0 0.0 -0.0 -0.6
Breast Cancer 0.3 0.7 2.7 0.3 0.4 0.7 0.1 1.2 1.0 0.3 0.8 1.0 -0.9 -0.8 -0.9 0.7 -0.8 0.8 0.8 0.6 1.6 0.7 0.9 0.3
Ovarian Cancer 0.2 0.3 2.3 0.8 0.5 0.1 1.5 0.3 0.5 0.2 0.3 -0.2 -0.1 -0.3 -0.3 0.4 -1.1 0.3 0.1 -0.2 0.7 0.2 0.8 0.5
Prostate Cancer 0.6 0.9 3.1 -0.6 -0.9 -1.1 -1.1 -1.3 -0.7 -0.2 -1.0 -0.8 1.0 1.1 1.1 -0.9 1.2 -0.9 -0.8 -0.3 -0.2 -0.6 -0.7 -1.8
Age at First Birth 0.1 0.2 1.2 -1.1 0.2 -0.2 -0.6 -0.2 -0.2 0.4 0.2 -0.3 0.4 0.2 0.3 -0.1 0.5 0.3 -0.1 0.4 -0.0 -0.1 -0.5 -0.7
Bipolar Disorder (2011) 1.0 1.0 3.2 -0.2 -1.0 -1.0 -1.3 -0.8 -0.6 -1.8 -0.8 -0.9 0.6 0.9 0.9 -1.1 -0.8 -1.0 -0.8 -1.7 -0.5 -1.0 -0.9 0.7
Body Mass Index (BMI) (2010) 0.7 1.0 5.0 -0.4 0.9 0.7 0.8 0.8 0.6 2.2 0.8 -0.3 -1.0 -0.8 -0.7 0.7 -1.1 1.1 0.8 0.5 2.1 0.6 1.0 -0.2
Coronary Artery Disease (CAD) 0.3 0.4 2.2 0.5 0.1 0.4 0.8 -0.3 -0.8 -1.5 -0.1 -1.0 -0.2 -0.1 -0.1 0.0 -0.9 -0.1 0.3 0.6 0.6 0.3 0.7 1.1
Crohns Disease (2012) 0.7 1.1 2.9 -0.3 -1.2 -1.3 -0.9 -1.2 -0.5 -1.3 -1.3 -0.4 0.6 1.4 1.3 -1.3 0.6 -1.4 -1.2 -1.7 -0.6 -1.0 -0.7 -0.6
Mean Putamen Volume 0.8 0.9 3.7 -0.9 1.4 1.0 0.4 0.5 0.6 1.7 1.0 1.9 -1.3 -0.8 -0.8 1.0 0.4 1.3 0.8 0.4 -0.3 0.5 0.6 0.3
Fasting Glucose 1.0 1.2 3.8 -0.5 -1.8 -1.2 -0.5 -0.5 0.5 0.6 -1.0 -0.6 0.8 0.9 0.9 -1.6 0.4 -1.2 -1.1 -1.9 -0.7 -1.6 -1.4 -1.2
HbA1C 0.7 0.8 3.3 0.4 0.8 0.8 1.0 0.6 0.4 1.8 0.8 0.1 -0.8 -0.8 -0.7 0.8 -1.2 0.7 0.6 0.4 1.1 0.6 1.2 1.3
HDL Cholesterol 0.5 0.8 4.0 -1.4 -0.2 -0.5 -2.0 -0.3 -0.2 0.3 -0.7 -0.9 0.7 0.7 0.6 -0.2 1.8 -0.2 -0.6 -0.1 -1.2 -0.3 -0.7 -1.6
LDL Cholesterol 0.8 1.3 3.0 -0.7 -1.1 -1.4 -1.0 -1.4 -0.8 -0.6 -1.5 -1.2 1.1 1.3 1.3 -1.3 0.8 -1.2 -1.7 -1.5 -0.6 -1.2 -0.8 -0.5
Lupus 0.7 1.0 2.9 -0.8 -0.9 -1.0 -1.7 -0.9 0.2 -1.1 -0.9 0.2 0.3 1.0 1.0 -1.1 1.1 -0.9 -1.2 -1.5 -1.0 -0.8 -1.1 -1.3
Neuroticism (2016) 1.7 2.5 6.8 -0.4 1.5 1.9 1.2 1.8 2.6 0.3 1.9 2.1 -1.9 -1.9 -1.9 1.5 -0.9 2.0 1.1 1.7 0.8 1.8 0.9 0.2
Primary Biliary Cirrhosis 2.0 2.8 4.1 -1.9 -2.0 -1.6 -1.8 -1.6 -1.6 -0.5 -1.8 -1.6 1.6 1.6 1.6 -1.9 1.5 -1.6 -1.7 -1.5 -1.6 -1.9 -2.0 -1.4
Rheumatoid Arthritis 0.3 0.4 2.0 -0.6 0.3 0.7 -0.4 0.8 1.4 0.0 0.5 0.8 -0.9 -0.7 -0.7 0.3 -0.0 0.5 0.4 0.5 0.2 0.6 -0.0 -0.2
Schizophrenia (2014) 2.9 6.4 10.9 -1.2 -2.9 -2.8 -0.6 -3.3 -3.2 -1.1 -2.9 -2.3 2.1 2.9 2.9 -3.0 2.3 -3.1 -2.7 -2.4 -2.8 -2.4 -2.7 -1.0
Triglycerides 1.4 2.3 3.8 -1.3 -1.9 -1.9 -0.5 -1.7 -0.7 0.1 -1.7 -1.1 1.5 1.8 1.9 -1.9 1.2 -1.7 -1.7 -1.9 -0.6 -1.5 -1.8 -1.4
Type 2 Diabetes (T2D) (2012) 1.6 1.8 5.2 1.0 1.1 0.8 1.2 1.4 1.9 1.7 1.3 1.8 -1.8 -1.0 -1.0 0.8 -1.6 1.3 1.0 0.3 2.3 1.8 1.2 0.5
Ulcerative Colitis 0.1 0.1 0.8 0.3 0.2 0.0 -0.1 0.2 0.0 0.5 0.1 0.5 -0.3 -0.0 -0.0 0.2 -0.9 0.2 -0.0 0.0 0.7 0.4 0.2 -0.0
Blood Eosinophil Count 0.1 1.0 6.3 -1.6 -0.8 -0.9 0.3 -0.9 0.3 -0.3 -0.8 0.1 0.4 0.9 0.9 -0.8 2.5 -0.6 -0.8 -0.9 -0.8 -1.0 -1.2 -1.6
Blood Platelet Count 0.0 0.5 2.4 -0.6 -0.4 0.7 0.2 0.5 0.7 -0.9 0.8 0.5 -0.9 -0.9 -0.9 -0.5 -1.6 0.0 0.5 0.2 1.4 -0.7 0.1 -0.0
Blood Red Count 2.3 21.8 32.0 5.5 4.3 4.9 4.8 5.0 3.5 2.7 4.8 4.1 -4.5 -5.0 -5.0 5.1 -5.7 4.0 4.7 4.1 4.2 4.5 5.3 5.3
Blood White Count 0.2 1.6 4.1 1.6 0.8 1.3 0.5 0.8 0.2 0.5 1.3 1.5 -1.7 -1.4 -1.4 1.2 0.6 0.7 1.6 2.0 1.5 1.7 1.6 0.5
Heel T-Score 0.3 2.5 7.7 -0.7 -1.2 -1.7 -1.3 -1.6 -1.0 -0.9 -1.6 -0.9 0.9 1.5 1.5 -1.2 2.1 -1.5 -1.7 -1.6 -2.8 -2.2 -1.9 -1.2
BMI 0.1 0.7 3.0 0.7 0.2 0.3 -0.2 0.4 -0.5 1.3 0.4 -0.2 0.1 -0.4 -0.5 0.8 -1.6 -0.2 1.0 0.5 0.9 0.5 1.2 1.7
Height 0.9 18.1 31.9 3.6 4.5 5.2 4.3 4.5 2.0 1.5 4.5 5.2 -4.8 -4.5 -4.5 5.2 -2.1 4.1 4.6 5.7 -0.8 5.6 3.1 4.6
Waist Hip Ratio (WHR) 0.2 0.8 2.9 0.9 -1.7 -0.8 -0.5 -0.8 -0.6 -1.4 -0.8 -0.4 0.5 0.7 0.6 -1.2 -0.9 -1.7 -0.5 -1.1 -0.7 -0.4 -0.7 0.8
Systolic Blood Pressure 0.6 3.0 5.0 -1.0 -2.2 -1.8 -1.9 -1.4 -0.5 -1.1 -2.0 -0.9 1.9 1.8 1.7 -1.9 2.2 -2.0 -1.6 -1.9 -1.7 -1.6 -2.0 -1.8
Smoking Status 0.3 0.8 4.7 -2.2 -0.7 0.1 -0.5 -0.8 0.8 0.2 -0.2 -0.7 0.1 0.1 0.1 -1.0 1.2 -0.6 0.1 -0.3 -1.8 -0.3 -1.6 -0.0
Allergy or Eczema 0.8 2.0 5.0 -1.1 -1.5 -1.6 -0.6 -1.4 -0.6 -2.2 -1.5 -1.3 1.3 1.5 1.6 -1.4 1.4 -1.7 -1.8 -1.6 -1.6 -1.3 -0.9 -0.2
Cardiovascular Disease 0.8 2.7 4.8 -1.5 -2.2 -1.8 -1.3 -1.5 -0.4 -0.9 -1.7 -1.9 2.0 1.7 1.7 -1.9 1.8 -1.9 -1.8 -1.6 -1.1 -1.3 -1.8 -1.9
Hypothyroidism (self reported) 0.1 0.2 0.7 -0.0 0.4 0.1 0.8 0.1 0.9 -0.6 -0.1 -0.7 -0.3 -0.0 -0.1 0.4 0.3 0.1 0.2 0.3 -0.1 0.3 0.4 0.8
Respiratory disease 0.1 0.2 0.7 -0.7 0.1 0.3 0.3 0.3 0.6 0.8 0.2 0.3 -0.1 -0.2 -0.3 0.0 -0.4 0.3 0.3 -0.6 0.2 -0.6 -0.1 0.4
Type 2 Diabetes (T2D) (2018) 1.4 2.7 4.8 1.3 1.3 1.5 2.0 1.8 0.7 0.8 1.6 1.6 -1.5 -1.6 -1.6 1.8 -1.9 1.2 1.8 1.5 2.0 1.9 2.2 1.8
Lung FEV1/FVC ratio 0.3 1.6 3.4 -0.7 1.4 1.5 0.9 1.7 1.8 0.9 1.5 0.1 -1.3 -1.6 -1.5 1.2 -1.3 1.7 1.6 1.0 0.5 1.1 0.4 0.7
Lung FVC 0.4 2.0 7.2 -2.4 -0.9 -0.9 -2.3 -0.6 -0.3 -2.7 -1.1 -1.4 1.5 1.0 0.9 -1.5 1.1 -0.4 -1.4 -1.2 -0.9 -1.3 -1.7 -1.5
Neuroticism 0.1 0.3 3.0 -0.6 0.3 0.4 -0.4 0.3 1.7 0.5 0.4 -0.4 -0.4 -0.4 -0.4 0.0 -0.1 0.4 0.0 -0.4 -0.3 0.2 -0.3 0.1
Chronotype (morning person) 0.7 1.7 10.3 -2.6 -0.0 -0.6 -2.5 -0.7 0.2 -0.2 -0.5 -1.3 1.0 0.6 0.6 -0.7 1.8 0.6 -0.6 -0.2 0.7 -0.8 -1.4 -3.2
Hair Pigment 0.0 0.1 1.0 0.1 -0.3 -0.1 -0.3 -0.3 -0.8 -0.1 -0.4 0.1 0.2 0.2 0.2 0.2 0.0 -0.5 -0.1 1.0 -0.7 0.0 -0.2 -0.2
Tanning 0.0 0.1 0.5 -0.3 0.7 -0.0 0.4 -0.1 0.5 0.3 -0.0 -0.2 -0.7 0.1 0.1 0.4 0.5 0.5 -0.4 0.0 -0.7 0.0 -0.2 -0.3
Hand grip strength (left) 1.3 3.4 5.3 2.3 1.8 2.2 2.3 2.0 0.0 1.7 2.0 1.5 -1.6 -2.1 -2.1 1.9 -1.4 1.6 2.0 2.3 0.3 2.3 1.5 1.7
Number of treatments/medications taken 1.9 3.4 6.4 -2.5 -2.1 -1.6 -1.3 -2.0 -1.9 -2.5 -1.7 -1.9 1.5 1.6 1.6 -2.2 1.5 -1.7 -1.4 -1.7 -1.6 -2.0 -2.4 -1.4
Average weekly spirits intake 0.1 0.2 0.7 -0.1 -0.5 -0.3 0.5 -0.2 -0.4 -0.1 -0.4 -0.3 0.1 0.4 0.3 -0.5 0.1 -0.5 -0.3 -0.8 -0.3 -0.8 -0.6 -0.1
Sensitivity / hurt feelings 0.8 1.4 2.7 -0.5 1.6 1.4 1.0 0.9 1.1 0.5 1.2 0.7 -1.5 -1.3 -1.3 1.1 -1.2 1.5 1.3 1.5 0.9 1.5 0.9 0.4
Frequency of depressed mood in last 2 weeks 1.5 2.0 5.0 0.8 1.4 1.5 1.3 1.6 1.1 1.8 1.6 1.1 -1.0 -1.5 -1.5 1.3 -2.2 1.4 1.4 0.8 1.5 1.2 1.7 1.5
Hearing difficulty/problems: Yes 0.4 0.5 3.5 1.1 0.3 0.6 0.5 0.8 0.3 0.6 0.6 0.3 -0.4 -0.7 -0.7 0.5 -1.9 0.2 0.8 0.5 -0.1 0.7 0.4 1.2
Relative age of first facial hair 0.3 0.7 1.6 -1.1 -0.7 -0.9 -0.5 -0.5 0.4 0.4 -0.9 -0.3 0.6 0.8 0.8 -1.0 0.4 -0.7 -0.9 -1.0 -1.0 -1.0 -1.3 -1.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 1.6 -0.0 0.1 0.4 0.8 0.1 -0.4 -0.0 0.3 0.1 0.5 -0.3 -0.3 0.2 -0.3 -0.0 0.4 -0.1 -0.9 -0.1 0.1 1.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.3 0.5 -0.1 -0.3 -0.5 -0.7 -1.1 -0.8 -0.2 -1.1 0.3 0.3 0.3 -0.4 0.1 -0.4 -0.3 -0.3 -1.0 -0.3 0.1 0.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.5 -0.1 -0.1 -0.1 0.5 -0.1 -0.7 -0.6 -0.0 -0.5 0.0 -0.0 -0.0 -0.2 -0.1 -0.1 0.0 -0.5 0.4 -0.7 0.0 -0.1
Systolic blood pressure, automated reading 1.2 3.4 6.8 -1.5 -2.1 -2.1 -2.6 -1.7 -1.0 -0.5 -2.1 -1.6 2.0 2.0 2.0 -1.8 2.1 -2.0 -1.6 -1.9 -1.5 -1.8 -2.0 -1.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.6 0.5 -0.2 -0.5 0.9 -0.5 -1.3 0.8 -0.3 0.3 0.0 0.4 0.4 0.0 -0.9 -0.6 -0.3 -0.3 0.2 -0.3 0.4 0.6
Angina 0.3 0.4 2.0 -0.7 0.3 0.6 1.4 0.2 0.0 0.5 0.7 0.9 -0.2 -0.7 -0.6 0.5 -0.5 0.6 0.7 0.3 0.1 -0.7 -0.3 0.9
Medication for hormone replacement therapy 1.0 1.1 6.2 2.5 0.2 0.8 2.0 0.5 -0.8 0.0 0.9 -0.2 -0.5 -0.8 -0.8 0.6 -1.0 0.0 1.0 0.5 -0.3 0.5 0.9 2.2
Vitamin and mineral supplements 4.3 5.8 11.0 3.1 1.9 2.6 2.1 2.6 0.5 1.5 2.4 1.6 -3.3 -2.6 -2.7 2.3 -2.2 2.0 2.9 2.7 2.7 2.6 2.7 1.9
Supplements: Zinc 2.2 2.4 3.7 -1.4 -1.5 -1.7 -1.2 -1.6 -0.4 -1.1 -1.6 -1.8 1.7 1.6 1.7 -1.7 1.0 -1.3 -1.7 -1.6 -1.5 -1.7 -1.8 -1.9
Medication: Co-codamol 0.3 0.3 1.2 -0.4 0.6 0.4 0.2 0.4 0.5 1.1 0.2 0.7 0.6 -0.3 -0.3 0.6 -0.5 0.2 0.3 1.0 -0.4 1.1 0.6 0.5
Medication: Metformin 1.0 1.3 4.5 1.2 1.0 0.7 2.0 0.7 -0.8 0.3 0.9 0.9 -1.1 -0.8 -0.8 1.4 -1.2 0.5 1.2 1.1 1.3 1.3 2.1 1.6
Diabetes (father) 0.3 0.3 2.9 0.1 -0.5 -0.5 -1.7 -0.4 -0.8 -0.7 -0.4 0.4 -0.1 0.3 0.2 -0.2 0.2 -0.4 -0.3 -0.1 -0.6 -0.6 -0.3 -0.8
Diabetes (mother) 0.4 0.5 2.0 0.3 0.3 0.2 0.2 0.4 -1.4 1.1 0.3 -0.3 0.4 -0.4 -0.3 0.5 -1.1 -0.0 0.6 0.6 1.3 0.7 1.2 1.1
Severe depression (siblings) 1.8 2.1 4.5 -1.3 -1.5 -1.4 -1.8 -1.1 -0.4 0.8 -1.6 -0.6 1.6 1.4 1.4 -1.3 1.1 -1.3 -1.8 -1.7 -1.7 -1.2 -1.7 -2.1
Pack years adult smoking proportion 0.1 0.2 0.6 -0.5 -0.1 -0.4 -0.5 -0.8 -0.5 0.3 -0.3 0.0 0.6 0.4 0.4 -0.3 -0.5 -0.3 -0.7 -0.4 -0.5 -0.4 -0.0 0.3
Impedance of leg (right) 0.1 0.6 3.1 -1.1 -0.8 -0.4 -1.0 -0.5 0.3 0.1 -0.4 -0.2 0.2 0.5 0.5 -1.1 0.6 -0.2 -0.8 -1.0 -0.7 -1.2 -1.7 -0.9
Leg fat-free mass (left) 0.6 3.3 7.3 2.2 1.5 1.7 2.2 1.9 0.7 0.2 1.5 1.9 -1.3 -1.7 -1.8 2.3 -1.2 0.9 2.3 2.1 0.8 2.3 2.3 2.7
Trunk fat percentage 0.5 2.0 4.3 0.1 1.1 1.4 0.9 1.5 1.0 0.9 1.5 1.8 -1.2 -1.5 -1.6 1.4 -1.4 1.1 2.0 1.4 2.1 1.4 1.5 1.2
Hand grip strength (right) 0.9 2.3 4.8 1.8 1.6 1.8 2.2 1.7 0.4 1.0 1.6 1.1 -0.9 -1.7 -1.6 1.6 -1.1 1.4 1.8 1.9 0.2 2.2 1.2 1.4
Townsend deprivation index at recruitment 1.2 1.6 3.2 -1.1 -1.0 -1.5 -1.8 -1.7 -1.1 0.6 -1.6 -1.4 1.4 1.5 1.5 -1.1 0.8 -1.4 -1.5 -1.1 -1.3 -1.1 -0.8 -0.7
Current tobacco smoking 0.2 0.4 1.1 -0.9 0.5 0.9 0.4 0.1 0.4 1.0 0.6 0.4 -1.0 -0.7 -0.7 0.3 -0.7 0.4 0.5 0.7 -0.7 0.4 0.1 0.9
Average weekly fortified wine intake 2.0 2.4 5.4 2.0 1.4 1.3 2.0 1.4 0.2 1.9 1.4 0.3 -1.4 -1.4 -1.4 1.5 -1.6 1.2 1.4 1.4 2.3 1.8 2.0 1.2
Maternal smoking around birth 0.2 0.3 1.3 -0.6 -0.4 -0.2 -0.6 -0.2 0.8 1.2 -0.4 0.8 0.0 0.2 0.2 -0.3 1.0 -0.4 -0.2 0.1 -0.3 0.8 -0.2 -0.6
Fed-up feelings 1.1 2.0 3.7 1.0 1.3 1.6 0.5 1.5 1.8 1.6 1.7 0.9 -1.9 -1.8 -1.8 0.9 -1.6 1.6 1.6 0.8 1.8 1.3 0.8 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 3.3 1.1 1.3 1.3 0.7 1.4 1.5 1.4 1.4 0.9 -1.1 -1.3 -1.4 1.2 -1.8 1.3 1.2 1.0 1.5 1.4 1.5 0.8
Relative age voice broke 0.3 0.4 1.5 -0.7 -0.2 -0.6 -0.4 -0.3 0.3 0.8 -0.6 -0.7 0.7 0.7 0.6 -0.6 -0.7 -0.4 -0.4 -0.9 -1.2 -1.0 -1.0 -0.1
Taking other prescription medications 0.2 0.2 1.6 -0.2 -0.5 -0.0 -0.0 -0.4 -0.9 -0.6 -0.1 -0.5 -0.1 0.0 0.0 -0.3 -0.8 -0.5 0.2 -0.2 0.0 -0.5 -0.3 1.3
Age when periods started (menarche) 0.2 0.5 3.0 -0.7 0.7 0.6 0.8 0.2 0.6 1.7 0.5 1.1 -0.8 -0.5 -0.5 0.0 -0.6 0.8 0.3 0.5 -0.4 0.3 -0.3 0.3
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.4 -0.5 0.9 0.6 0.7 0.7 1.4 0.3 0.8 0.6 -1.2 -0.7 -0.6 0.5 -0.8 1.0 0.7 0.3 1.6 0.6 0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.8 -0.1 -1.3 -1.3 -0.7 -1.1 -1.2 -1.1 -1.2 -2.0 1.3 1.1 1.1 -1.0 1.2 -1.4 -1.1 -1.0 -0.8 -1.3 -0.9 -0.7
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 1.0 -0.2 -0.2 0.0 -0.0 0.2 0.1 0.5 -0.0 -1.0 0.8 0.0 0.0 -0.1 -0.6 -0.1 0.0 -0.4 0.4 -0.3 0.1 0.3
Qualifications: CSEs or equivalent 0.1 0.2 0.5 0.1 -0.2 0.4 -0.5 0.5 -0.5 0.5 0.3 0.3 -0.7 -0.5 -0.5 0.2 -0.7 0.1 0.4 0.3 0.5 -0.1 0.2 -0.3
Serious illness, injury or assault to yourself 0.4 0.5 1.9 -0.3 -0.8 -0.6 -0.3 -0.9 -1.2 0.3 -0.6 -1.1 0.3 0.6 0.6 -0.7 0.0 -0.8 -0.4 -0.5 -1.4 -0.6 -0.5 -0.1
High blood pressure 0.2 0.5 2.6 -1.2 -0.6 -0.6 -1.6 -0.4 -0.3 0.4 -0.5 -1.2 0.7 0.4 0.4 -0.5 0.7 -0.3 -0.5 -0.1 0.0 -0.6 -0.7 -1.0
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.9 -1.0 -1.1 -1.1 -0.4 -0.8 0.3 -2.0 -1.0 -0.7 1.2 1.1 1.1 -1.1 1.2 -1.1 -1.4 -1.3 -1.0 -0.9 -0.7 -0.3
Multivitamins +/- minerals 1.4 1.8 5.9 -1.5 -1.0 -1.4 -1.4 -1.4 -0.2 -0.5 -1.5 -0.8 2.4 1.6 1.6 -1.2 1.0 -1.2 -1.6 -1.1 -1.6 -1.3 -1.5 -0.8
Stomach or abdominal pain in last month 0.5 0.6 2.0 0.2 0.7 0.7 0.8 1.0 1.4 0.4 0.7 0.4 -0.2 -0.7 -0.8 0.4 -0.9 0.8 0.8 0.2 0.9 1.1 0.7 0.6
Supplements: Glucosamine 1.0 1.3 5.2 -0.8 -0.9 -1.2 -1.1 -1.2 -1.6 -2.3 -1.1 -1.0 0.9 1.1 1.1 -1.2 0.5 -0.8 -1.1 -1.1 -0.0 -0.9 -0.9 -1.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 6.1 1.0 -0.2 0.5 -0.1 0.4 -0.4 -0.6 0.5 0.4 -1.0 -0.5 -0.6 0.4 -1.7 -0.3 0.8 -0.3 0.3 -0.3 0.4 2.5
Medication: Atenolol 0.2 0.2 2.2 0.0 0.5 0.4 0.3 0.1 -0.8 1.5 0.4 0.1 0.2 -0.2 -0.2 0.6 0.2 0.4 0.3 0.3 -0.2 -0.4 0.1 0.4
Medication: Levothyroxine sodium 1.2 2.0 7.3 1.4 1.4 1.6 1.8 1.3 0.5 0.2 1.4 0.2 -1.6 -1.5 -1.5 1.5 -1.6 1.1 1.6 1.2 0.8 1.1 1.5 2.7
Sitting height 0.4 3.0 6.8 1.8 1.9 1.6 2.6 1.7 1.7 -1.0 1.4 1.8 -1.2 -1.4 -1.4 2.1 -0.9 1.2 1.7 1.9 0.2 2.6 2.0 2.2
Chronic bronchitis/emphysema (father) 3.2 3.7 6.5 1.9 1.8 2.0 2.2 1.8 1.3 0.5 2.2 0.9 -1.6 -2.1 -2.1 2.0 -1.6 1.5 2.3 1.8 2.2 2.3 2.5 2.3
High blood pressure (mother) 4.9 6.9 12.8 -3.2 -2.9 -2.6 -2.0 -2.4 -1.5 -2.1 -2.6 -2.0 2.5 2.5 2.5 -2.9 2.8 -2.4 -2.5 -2.5 -2.6 -3.0 -3.6 -3.3
Body mass index (BMI) 0.3 1.3 3.6 0.5 0.9 0.9 0.5 1.1 0.6 1.0 1.1 1.0 -0.8 -1.2 -1.2 1.3 -1.5 0.6 1.6 1.0 1.9 1.1 1.7 1.5
Impedance of leg (left) 0.1 0.3 1.5 -0.8 -0.4 -0.1 -0.9 -0.3 0.5 0.3 -0.1 0.4 -0.2 0.3 0.2 -0.7 -0.1 0.1 -0.6 -0.6 -0.3 -0.7 -1.2 -0.6
Leg predicted mass (left) 0.6 3.1 6.8 2.1 1.5 1.7 2.1 1.9 0.7 0.0 1.5 1.9 -1.2 -1.7 -1.7 2.2 -1.1 0.9 2.2 2.1 0.8 2.3 2.2 2.6
Trunk fat mass 0.8 3.4 6.4 0.9 1.6 1.9 1.6 2.0 1.1 0.9 1.9 2.4 -1.7 -2.0 -2.0 2.1 -1.6 1.4 2.5 2.0 2.0 2.1 2.1 2.0
Waist circumference 0.5 2.0 4.7 1.2 0.9 1.2 1.0 1.3 0.7 1.0 1.3 1.8 -1.3 -1.4 -1.4 1.5 -1.8 0.6 1.8 1.4 1.3 1.8 1.7 2.2
Number of incorrect matches in round 1.6 2.6 5.1 -0.9 -1.8 -1.7 -0.7 -1.6 -1.6 -0.6 -1.7 -2.1 1.6 1.8 1.7 -1.8 1.2 -1.9 -1.5 -2.2 -1.1 -2.3 -2.0 -0.4
Past tobacco smoking 0.6 1.2 3.2 1.8 1.0 0.7 0.7 0.8 -1.1 0.8 0.7 0.6 -0.9 -0.8 -0.8 1.3 -1.8 0.8 0.5 1.1 1.4 0.3 1.7 1.3
Alcohol usually taken with meals 0.6 1.0 5.4 -0.8 -1.4 -0.8 -0.9 -0.8 -2.3 -0.7 -0.7 -0.6 0.8 0.7 0.8 -1.1 -0.1 -0.8 -0.5 -0.7 0.8 -1.6 -1.0 -0.9
Nervous feelings 0.1 0.2 1.2 -1.1 -0.1 -0.2 0.4 -0.3 1.1 -0.4 -0.1 0.1 -0.2 0.2 0.2 -0.3 0.7 -0.0 -0.3 -0.5 -0.7 -0.2 -0.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.1 1.2 1.1 1.0 0.4 1.1 1.8 0.8 1.0 0.8 -0.8 -1.0 -1.1 1.1 -1.8 1.1 1.0 0.5 0.9 0.8 1.0 0.5
Hearing difficulty/problems with background noise 0.4 0.7 1.3 -1.0 -1.1 -1.0 -0.6 -1.0 -0.6 0.3 -0.8 -0.3 0.8 1.0 1.0 -0.8 0.1 -1.0 -1.0 -1.0 -1.0 -0.9 -1.1 -0.3
Hair/balding pattern: Pattern 2 0.3 0.3 3.2 0.9 0.1 0.6 0.5 0.4 0.1 0.1 0.6 -0.6 -0.4 -0.6 -0.6 0.2 -0.4 0.1 0.3 -0.6 -0.3 -0.0 0.3 1.8
Had menopause 0.3 0.4 1.3 0.9 1.1 0.3 0.3 0.3 0.5 0.4 0.5 -0.5 -0.3 -0.3 -0.3 0.8 -1.1 0.8 0.3 0.2 -0.3 0.4 0.7 0.9
Had other major operations 1.1 1.4 4.0 -0.2 -1.3 -1.2 -0.6 -1.2 -0.5 -0.7 -1.4 -1.6 1.2 1.2 1.3 -1.5 1.0 -1.6 -1.3 -1.2 -2.0 -0.6 -0.9 -0.3
Forced vital capacity (FVC) 0.3 1.3 4.0 1.1 1.0 1.4 1.1 1.7 0.8 -0.7 1.0 0.3 -0.5 -1.2 -1.3 1.2 -1.2 1.0 1.1 1.0 -0.1 1.3 0.8 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.3 -0.4 -1.2 -1.3 -1.1 -1.1 -1.2 -0.8 -1.1 -1.3 1.0 1.1 1.1 -1.0 1.1 -1.4 -1.2 -1.2 -1.0 -1.5 -1.1 -0.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 -0.6 0.5 0.8 0.7 1.0 1.1 1.2 0.7 0.6 -0.2 -0.8 -0.9 0.3 -1.1 0.8 0.8 0.1 0.0 0.1 0.4 0.3
Qualifications: None of the above 1.3 2.8 5.2 1.7 2.3 2.0 0.9 1.4 1.2 -0.5 2.0 0.3 -1.8 -1.9 -1.9 1.9 -0.9 2.0 2.1 2.1 1.1 2.0 1.8 1.4
Financial difficulties in last 2 years 0.5 0.7 3.6 1.9 0.5 0.3 0.9 0.2 -1.4 1.0 0.4 -0.2 0.2 -0.3 -0.3 0.5 -1.6 0.0 0.4 0.1 -0.6 0.3 0.7 1.8
Mouth/teeth dental problems 0.3 0.5 4.2 -1.1 0.2 -0.4 -0.1 0.1 0.8 0.7 -0.2 -0.3 0.6 0.3 0.3 -0.2 1.1 0.6 -0.7 -0.3 0.3 -0.7 -0.6 -2.1
Heart attack 0.2 0.3 1.7 -0.2 0.2 0.5 0.3 0.3 1.3 -0.4 0.5 0.2 -0.4 -0.4 -0.4 0.1 -0.3 0.5 0.7 -0.2 -1.3 -0.3 -0.7 0.5
Allergy 0.2 0.4 1.3 1.0 0.4 0.5 0.1 0.3 -0.6 1.1 0.5 0.8 -0.6 -0.5 -0.5 0.6 -0.6 0.6 0.9 0.9 0.7 0.6 0.2 -0.4
Pain all over the body in last month 1.0 1.1 3.0 -1.4 -0.8 -0.9 -1.0 -0.9 -1.0 -0.1 -0.9 -1.0 1.1 0.9 0.9 -1.1 1.5 -0.5 -0.8 -0.9 -0.7 -1.1 -1.3 -1.7
Diabetes (self-reported) 2.1 3.3 6.2 1.4 1.9 1.7 2.0 1.8 0.8 1.1 1.8 1.9 -1.9 -1.8 -1.8 2.2 -1.8 1.5 1.9 1.5 1.9 1.8 2.5 2.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 3.5 -0.8 -0.8 -0.7 0.1 -0.3 0.5 -1.9 -0.6 -0.1 0.8 0.6 0.7 -0.5 0.7 -0.9 -0.6 -0.8 -1.0 -0.5 -0.5 0.0
Medication: Ramipril 0.7 0.9 3.5 0.8 1.2 1.0 1.0 0.9 0.4 0.1 0.9 -0.4 -0.4 -0.9 -0.8 1.1 -0.7 0.6 1.0 1.2 0.3 1.3 1.4 1.9
Medication: Simvastatin 0.3 0.4 0.9 0.5 -0.6 -0.7 -0.1 -0.8 -0.9 -0.7 -0.7 -0.9 0.9 0.7 0.7 -0.5 0.4 -0.8 -0.6 -0.7 0.6 -0.5 0.1 -0.0
Fluid intelligence score 0.6 1.2 4.0 -0.6 -0.6 -1.1 -0.9 -0.9 -0.7 0.4 -1.1 -1.4 1.5 1.1 1.2 -0.7 2.0 -0.8 -1.0 -0.7 -2.0 -0.4 -0.9 -1.3
Illnesses of siblings 0.4 0.6 1.4 -0.0 -1.2 -0.8 -0.8 -0.7 -0.7 0.2 -0.8 -0.1 1.0 0.9 0.9 -0.9 0.8 -1.0 -0.4 -0.8 -0.5 -0.7 -0.8 -0.5
Neuroticism score 0.2 0.4 2.9 -1.4 -0.1 -0.2 -0.5 -0.2 1.7 -0.4 -0.1 -0.7 0.1 0.1 0.1 -0.6 0.2 0.1 -0.5 -1.0 -0.0 -0.3 -0.6 -0.9
Weight 1.0 4.9 7.9 1.6 2.1 2.3 2.1 2.3 1.3 1.2 2.2 2.6 -2.0 -2.3 -2.3 2.7 -1.9 1.6 2.8 2.6 1.9 2.7 2.6 2.7
Impedance of arm (right) 0.1 0.6 2.8 -1.5 -0.8 -0.0 -0.6 0.1 0.7 0.3 -0.1 -0.1 0.3 0.1 0.1 -1.1 0.9 0.1 -0.3 -0.7 0.0 -0.7 -1.4 -1.7
Arm fat percentage (right) 0.4 1.6 6.2 0.2 0.7 1.2 0.7 1.3 0.6 1.0 1.3 0.9 -0.9 -1.4 -1.4 1.1 -1.5 0.7 1.9 0.9 2.5 1.0 1.6 1.4
Trunk fat-free mass 1.0 5.6 12.7 2.9 2.2 2.4 3.1 2.3 0.9 0.2 2.1 2.5 -2.0 -2.2 -2.2 3.1 -1.5 1.4 2.7 2.9 0.7 2.9 2.7 3.6
Hip circumference 0.9 4.0 6.6 1.2 1.9 2.0 1.6 2.0 1.4 2.0 1.9 2.2 -1.9 -2.0 -2.0 2.4 -1.6 1.6 2.4 2.2 1.8 2.4 2.2 2.6
Time employed in main current job 0.5 0.6 2.2 0.6 0.4 0.7 1.1 0.7 1.0 0.2 0.8 0.1 -1.0 -0.8 -0.9 0.4 -1.3 0.5 0.8 0.1 1.5 0.6 0.7 0.1
Alcohol intake versus 10 years previously 0.4 0.5 6.2 -0.6 -0.7 -0.1 -0.2 -0.7 -0.1 0.1 -0.5 0.1 0.1 0.2 0.2 -0.5 1.1 -0.7 -0.2 -0.2 -2.5 -0.2 -1.1 0.0
Father’s age at death 0.2 0.3 1.4 0.0 -0.3 -0.7 -0.6 -0.5 -0.9 0.1 -0.7 0.2 -0.1 0.6 0.6 -0.2 0.4 -0.3 -0.5 -0.0 -1.0 -0.4 -0.7 -1.2
Worrier / anxious feelings 0.2 0.3 2.9 -1.5 0.2 0.2 0.0 0.3 1.7 -0.1 0.2 -0.9 -0.2 -0.2 -0.2 -0.4 -0.1 0.4 -0.2 -0.6 0.2 -0.2 -0.4 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 1.0 0.7 -0.1 0.1 -0.2 0.4 0.7 -0.3 0.2 0.3 -0.1 -0.2 -0.3 0.2 -1.0 -0.2 0.1 -0.0 0.3 0.3 0.3 0.2
Falls in the last year 1.4 1.9 4.0 -0.5 -0.8 -1.6 -1.8 -1.5 -1.4 -0.6 -1.6 -1.9 2.0 1.7 1.6 -1.0 1.1 -1.3 -1.5 -1.2 -1.5 -1.2 -0.7 -0.7
Hair/balding pattern: Pattern 3 0.4 0.6 3.8 -1.0 0.4 0.3 0.9 0.4 0.3 -0.1 0.4 1.3 -1.1 -0.4 -0.4 0.3 0.9 0.7 0.4 1.0 1.1 0.5 0.1 -1.9
Number of live births 0.2 0.2 2.1 0.2 -0.1 0.0 1.4 -0.2 -1.5 -0.1 0.2 -0.6 -0.2 -0.1 -0.1 -0.0 -0.3 -0.1 0.3 0.3 0.2 -0.2 -0.1 0.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.1 1.3 1.5 1.9 1.4 2.2 1.5 -0.0 1.5 0.8 -0.9 -1.7 -1.8 1.6 -1.7 1.5 1.5 1.5 0.6 1.9 1.2 1.9
Pulse rate 1.1 1.8 7.5 2.7 1.2 0.8 0.6 0.9 0.6 1.3 0.9 0.7 -0.8 -0.9 -0.8 1.5 -2.0 0.7 1.1 1.0 1.3 1.6 2.1 2.0
Happiness 1.1 1.4 8.0 -0.4 1.6 1.1 1.1 1.1 1.5 2.8 0.9 0.7 -0.7 -0.9 -0.9 1.2 -0.8 1.3 0.8 0.7 0.1 1.1 1.3 1.1
Noisy workplace 0.3 0.3 2.0 0.8 0.4 0.3 1.1 0.1 0.5 -1.4 0.4 -0.1 0.0 -0.4 -0.4 0.7 -0.1 -0.1 0.4 0.6 0.0 0.5 1.0 0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.2 -0.4 -1.2 -1.1 -1.1 -0.4 0.8 -0.3 -1.1 -1.3 1.4 1.2 1.1 -1.1 1.3 -0.9 -1.2 -1.2 -0.7 -0.5 -1.0 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 3.9 -0.2 0.3 -0.1 -0.6 0.5 0.8 1.6 0.2 0.8 0.2 -0.1 -0.0 0.2 -0.2 0.4 -0.1 -0.4 2.0 0.2 0.3 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 0.4 0.3 0.6 0.4 -0.1 -0.8 0.2 0.5 0.5 -0.7 -0.6 -0.5 0.3 -0.4 0.1 0.9 0.9 0.1 0.7 0.6 0.7
Asthma 0.2 0.4 1.6 -0.6 -0.4 -0.1 0.0 -0.0 -0.8 0.8 -0.2 -0.2 0.4 0.1 0.0 -0.4 -1.0 -0.4 -0.2 -1.1 0.6 -1.3 0.0 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 2.1 -1.4 -0.3 -0.1 -0.4 0.0 0.1 0.5 -0.1 0.7 -0.2 0.1 0.0 -0.3 -0.1 0.2 -0.1 -0.1 0.4 -0.3 -0.9 -1.2
Medication: Cholesterol lowering 0.4 0.6 2.2 -1.1 -0.5 -0.8 -0.3 -0.8 -0.8 -1.5 -0.6 -0.9 1.0 0.7 0.8 -0.4 0.8 -0.4 -0.7 -0.3 -0.0 -0.7 -0.6 -1.3
Depression (self-reported) 0.1 0.1 0.6 -0.4 -0.1 0.2 -0.0 0.1 0.4 -0.0 0.1 -0.0 0.3 -0.1 -0.1 -0.2 -0.8 -0.1 -0.0 0.1 -0.4 0.2 -0.1 0.2
Medication: Lansoprazole 0.1 0.1 0.8 -0.9 0.1 0.1 0.1 -0.1 -0.1 0.7 0.2 -0.5 0.1 -0.2 -0.1 -0.1 0.2 0.4 0.2 0.2 -0.1 -0.3 -0.8 -0.3
Prospective memory result 0.3 0.3 2.0 0.0 -0.6 -0.5 -0.7 -0.4 0.5 -1.4 -0.4 0.5 -0.3 0.4 0.4 -0.5 -0.1 -0.7 -0.4 -0.8 0.6 -0.3 0.1 0.4
Lung cancer (father) 0.5 0.6 3.6 -1.7 0.0 -0.3 -0.8 -0.4 0.7 1.2 -0.2 0.2 0.6 0.4 0.4 -0.6 1.1 0.2 -0.5 -0.2 -0.5 0.2 -0.6 -1.9
Illnesses of mother 0.3 0.4 2.1 1.5 0.7 0.5 0.3 0.2 0.9 -0.7 0.4 0.0 -0.6 -0.4 -0.4 0.5 -0.3 0.5 0.4 0.4 0.4 0.9 1.1 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.2 -0.2 0.3 0.7 0.2 1.1 0.8 -1.1 0.3 -0.1 0.2 -0.5 -0.5 0.4 -0.0 0.5 0.5 0.5 -0.8 0.5 -0.3 1.1
Pulse wave Arterial Stiffness index 0.2 0.2 2.7 0.7 -0.6 -0.0 1.6 0.0 -0.6 0.1 -0.0 0.1 -0.1 0.0 0.0 0.0 -0.4 -0.7 0.4 0.3 0.2 0.2 0.1 0.6
Impedance of arm (left) 0.3 1.4 4.5 -2.1 -1.3 -0.8 -1.1 -0.7 0.1 -0.0 -0.9 -0.8 1.0 0.9 0.9 -1.7 1.2 -0.5 -1.1 -1.1 -0.7 -1.2 -2.0 -2.1
Arm fat mass (right) 0.7 2.7 5.0 1.1 1.3 1.6 1.3 1.7 0.9 1.0 1.6 1.6 -1.3 -1.7 -1.7 1.9 -1.8 1.0 2.2 1.6 2.2 1.7 2.2 2.2
Trunk predicted mass 1.0 5.8 12.6 2.9 2.3 2.4 3.1 2.3 0.9 0.3 2.2 2.6 -2.1 -2.3 -2.3 3.1 -1.5 1.5 2.8 2.9 0.7 3.0 2.7 3.6
Standing height 1.0 9.8 16.9 3.0 3.2 3.5 4.0 3.3 1.8 0.9 3.1 4.0 -3.3 -3.1 -3.1 3.8 -1.6 2.8 3.4 4.0 0.5 4.1 2.7 3.4
Length of working week for main job 0.1 0.2 0.7 -0.0 -0.5 -0.2 -0.0 0.0 0.2 0.4 -0.4 -0.2 0.5 0.3 0.3 -0.5 0.8 -0.5 -0.0 -0.6 -0.7 -0.2 -0.2 0.1
Exposure to tobacco smoke at home 0.5 0.6 1.8 0.7 0.1 1.0 0.4 0.7 0.2 0.0 0.9 0.4 -1.1 -1.0 -1.0 0.6 -0.8 0.1 1.0 0.8 0.8 0.8 0.4 1.4
Breastfed as a baby 2.1 2.5 4.7 1.9 1.5 1.6 -0.0 1.7 1.5 1.2 1.7 1.8 -2.2 -1.6 -1.6 1.8 -1.5 1.6 1.7 1.8 1.5 1.6 1.4 1.1
Tense / ‘highly strung’ 0.2 0.3 1.6 -0.4 -0.7 -0.4 0.2 -0.5 0.1 -1.2 -0.3 -0.9 0.8 0.3 0.3 -0.8 0.4 -0.4 -0.2 -0.5 -0.5 -0.4 -0.8 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 3.4 -1.8 -0.8 -0.8 -1.1 -0.7 0.3 0.1 -0.9 -1.4 1.3 0.7 0.8 -1.3 0.3 -0.7 -0.9 -1.2 -0.9 -0.3 -0.8 -1.4
Hair/balding pattern: Pattern 4 0.8 1.9 3.5 1.5 1.3 1.4 1.1 1.4 0.6 1.6 1.5 1.8 -1.1 -1.4 -1.4 1.5 -1.4 1.4 1.6 1.9 1.3 1.5 1.2 0.6
Birth weight of first child 0.2 0.4 2.1 -0.7 -0.5 -0.6 -0.2 -0.8 -1.4 -0.7 -0.6 0.5 0.6 0.6 0.6 -0.4 0.7 -0.6 -0.4 -0.0 -0.5 0.0 -0.1 -0.9
Peak expiratory flow (PEF) 0.2 0.5 1.6 1.2 -0.1 0.8 1.1 1.1 -0.0 -0.6 0.6 -0.2 -0.1 -0.8 -0.8 0.2 -1.1 0.2 0.8 0.5 0.6 0.7 0.1 1.2
Pulse wave reflection index 3.5 4.3 8.2 -2.7 -2.4 -1.9 -0.8 -1.8 -1.7 -1.5 -2.0 -2.4 2.1 1.9 1.9 -2.4 2.2 -1.9 -1.8 -1.7 -1.4 -2.3 -2.9 -2.7
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.5 1.3 0.5 1.0 0.6 1.0 0.3 1.1 0.9 1.1 -0.6 -1.0 -1.1 0.8 -1.6 0.5 1.0 0.6 0.9 1.0 0.9 1.6
Loud music exposure frequency 0.2 0.2 0.7 -0.1 0.3 -0.2 0.4 0.4 0.8 0.3 0.1 0.6 0.9 0.0 0.0 0.1 -0.5 0.3 -0.1 -0.5 0.4 -0.2 0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.7 0.3 -0.4 -0.7 -0.4 -0.3 -1.3 -0.0 -0.7 -0.4 1.1 0.7 0.7 -0.1 0.2 -0.5 -0.8 -0.2 -0.1 -0.3 0.1 -0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.2 0.6 -1.1 -0.6 0.2 -0.6 -0.9 0.1 -0.6 -0.2 0.3 0.6 0.6 -0.5 0.0 -1.3 -0.4 -0.9 -0.7 -0.7 -0.5 1.5
Blood clot in the leg (DVT) 0.3 0.3 1.7 1.0 0.7 0.1 0.2 0.2 1.3 0.5 0.2 -0.1 -0.3 -0.1 -0.1 0.4 0.5 0.1 0.2 0.5 -0.5 1.3 1.0 -0.1
Medication: Paracetamol 0.7 1.2 3.0 -0.3 0.8 1.3 1.3 1.3 1.7 0.0 1.2 0.6 -1.5 -1.3 -1.4 0.5 -0.5 1.1 1.4 0.9 1.0 1.4 0.6 -0.3
Headache pain in last month 0.1 0.2 1.6 -0.6 -0.1 0.3 -0.4 0.4 0.6 1.3 0.3 -0.5 -0.3 -0.3 -0.3 -0.2 -0.4 0.3 -0.0 -0.1 0.5 0.1 -0.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.8 0.9 0.9 0.9 0.9 0.9 0.7 1.9 0.9 1.1 -1.3 -0.9 -0.9 0.6 -0.8 0.8 0.8 0.7 0.8 0.8 0.7 0.7
Glaucoma (self-reported) 0.3 0.3 2.2 -0.6 -0.7 -0.3 -0.4 -0.3 0.3 0.3 -0.4 -0.0 0.7 0.4 0.4 -0.7 0.4 -0.3 -0.3 -0.4 0.1 -0.5 -1.0 -1.5
Gout (self-reported) 0.1 0.2 1.1 0.8 0.2 -0.1 -0.3 -0.5 -1.0 -0.3 -0.1 -0.7 0.2 0.2 0.2 0.0 0.3 -0.2 -0.1 0.3 -0.4 -0.0 0.4 0.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.9 0.7 0.9 0.8 1.2 0.7 1.1 0.3 0.6 -0.3 -1.1 -0.8 -0.8 0.8 -0.9 0.6 0.8 0.6 0.6 0.8 0.9 1.7
Medication: Amlodipine 0.8 1.2 2.5 -0.5 -1.5 -1.1 -1.3 -1.0 -0.4 -1.5 -1.1 -1.4 1.0 1.0 1.0 -1.2 0.9 -1.6 -0.9 -0.9 -0.8 -1.0 -1.0 -0.2
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.5 -1.2 -0.8 -1.1 -0.8 -0.7 0.4 0.8 -1.0 -0.7 1.2 1.0 1.0 -1.0 0.2 -0.7 -1.0 -1.6 0.4 -1.2 -0.3 -1.0
Birth weight 0.1 0.3 1.0 -0.4 0.7 0.2 -0.6 0.2 0.5 0.1 0.2 0.9 -0.1 -0.3 -0.2 0.7 0.3 0.8 0.0 1.0 0.1 0.6 0.2 -0.7
Chronic bronchitis/emphysema (mother) 0.3 0.3 2.2 -0.5 0.5 0.3 0.1 0.3 1.4 0.6 0.1 1.5 -0.6 -0.2 -0.3 0.1 0.8 0.4 0.2 0.0 0.5 0.3 0.3 0.5
High blood pressure (siblings) 0.2 0.3 1.3 -0.8 -0.3 -0.5 -0.8 -0.4 -0.3 -0.8 -0.5 -0.4 0.4 0.4 0.4 -0.4 0.6 -0.4 -0.7 -0.0 -0.6 -0.3 -0.2 -1.1
Forced vital capacity (FVC), Best measure 0.1 0.3 2.7 -0.4 -0.0 0.2 -0.0 0.4 0.3 -1.7 -0.2 -0.5 0.7 0.1 0.0 0.0 0.6 0.0 -0.2 0.2 -1.4 0.2 -0.7 0.8
Body fat percentage 0.4 1.7 4.8 0.0 0.9 1.3 0.7 1.3 0.9 0.9 1.4 1.6 -1.2 -1.5 -1.5 1.3 -1.4 0.9 2.0 1.2 2.2 1.2 1.3 1.2
Leg fat percentage (right) 0.4 1.4 3.9 -0.0 0.8 1.2 0.5 1.2 1.1 1.1 1.3 1.3 -1.1 -1.4 -1.3 1.2 -1.2 0.9 1.7 0.9 2.0 1.0 1.1 1.2
Arm fat-free mass (right) 0.9 4.9 11.8 2.8 2.4 2.0 2.8 1.9 0.6 0.1 1.9 2.3 -1.9 -1.9 -1.9 3.0 -1.8 1.4 2.3 2.6 0.7 2.6 2.8 3.4
Exposure to tobacco smoke outside home 0.6 0.8 3.2 1.1 -1.4 -0.6 -0.8 -0.5 -1.8 -1.5 -0.6 -1.0 0.5 0.5 0.5 -0.8 -0.5 -1.6 -0.2 -0.6 0.1 -0.4 -0.1 0.7
Comparative body size at age 10 0.9 2.4 6.4 1.5 1.4 1.3 1.0 1.4 0.6 2.1 1.4 0.9 -1.3 -1.5 -1.5 1.5 -2.1 1.4 1.5 1.1 2.5 1.8 2.3 0.7
Number of full brothers 0.3 0.4 1.0 0.5 0.9 0.7 0.8 0.5 0.6 1.0 0.8 0.4 -0.6 -0.7 -0.7 0.6 -0.4 0.7 0.6 0.4 0.3 0.4 0.5 0.2
Worry too long after embarrassment 0.3 0.5 1.5 -1.2 -0.4 -0.7 0.2 -0.8 0.5 -0.5 -0.5 -1.0 0.0 0.7 0.6 -0.9 0.6 -0.2 -1.0 -1.0 -0.1 -0.8 -1.0 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 2.9 -1.4 -1.0 -1.5 -1.4 -1.4 -0.3 -1.3 -1.5 -1.7 1.4 1.4 1.4 -1.3 0.3 -1.3 -1.7 -1.6 -0.7 -0.8 -0.4 -0.4
Wheeze or whistling in the chest in last year 0.4 0.7 2.6 -0.2 0.7 0.7 0.7 0.7 1.6 1.3 0.8 0.2 -0.4 -0.8 -0.8 0.4 -0.9 0.6 0.5 -0.3 1.6 0.5 1.0 0.6
Number of children fathered 1.0 1.2 3.7 -0.6 -1.3 -1.1 -1.1 -1.1 -1.3 -0.1 -1.0 -0.8 0.8 1.1 1.1 -1.2 1.1 -1.0 -0.7 -1.1 -1.2 -1.2 -1.9 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 5.8 6.8 12.6 -3.2 -2.6 -2.7 -3.5 -2.5 -0.7 -2.0 -2.6 -2.6 3.0 2.7 2.7 -3.0 2.4 -2.3 -2.7 -2.4 -2.0 -2.3 -3.0 -2.4
Age at first live birth 0.0 0.1 0.4 0.2 0.4 0.0 -0.1 -0.0 0.2 0.6 -0.1 -0.1 0.7 0.0 0.1 0.2 0.1 0.4 -0.3 -0.1 -0.1 0.1 0.2 -0.3
Pulse wave peak to peak time 0.2 0.3 1.7 -0.5 0.9 0.4 -1.3 0.4 0.9 0.0 0.3 0.4 -0.2 -0.3 -0.4 0.4 0.2 1.0 -0.1 0.2 -0.1 0.3 0.2 -0.4
Health satisfaction 1.8 2.3 4.9 -0.3 1.7 1.8 2.1 1.4 0.7 1.4 1.8 0.4 -1.5 -1.8 -1.8 1.5 -1.4 1.8 2.2 1.7 1.3 1.5 1.3 1.0
Shortness of breath walking on level ground 3.3 3.9 6.1 0.7 1.9 2.1 2.5 1.8 1.0 1.2 2.3 2.1 -2.5 -2.1 -2.1 1.9 -2.0 2.0 2.5 2.0 2.0 2.2 1.9 1.6
Qualifications: College or University degree 0.4 1.4 3.4 -0.6 -1.1 -1.4 -0.5 -0.8 -0.5 0.7 -1.4 -0.3 1.3 1.5 1.4 -0.9 1.8 -1.1 -1.5 -1.4 -1.6 -0.7 -0.9 -1.3
Eye problems/disorders: None of the above 0.4 0.5 2.0 0.3 0.5 0.7 -0.2 0.9 1.4 0.7 0.6 0.6 -0.3 -0.7 -0.7 0.3 -0.4 0.9 0.6 0.5 0.8 1.4 0.3 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.5 1.1 -1.3 -0.7 -1.1 -0.9 -0.4 -1.3 -0.9 0.3 0.2 0.8 0.8 -0.8 0.2 -1.6 -0.5 -1.0 -0.9 -0.5 -0.4 0.9
Emphysema/chronic bronchitis 0.1 0.1 0.7 -0.2 0.8 0.0 0.0 -0.3 -0.1 0.7 -0.1 0.3 0.1 0.1 0.0 0.3 0.1 0.2 0.0 0.3 -0.8 -0.0 0.5 -0.2
Medication for pain relief, constipation, heartburn 0.1 0.2 1.4 0.5 0.3 -0.4 -0.9 -0.1 0.2 1.2 -0.3 0.3 0.4 0.5 0.5 0.2 0.2 -0.1 -0.6 -0.4 -0.1 -0.4 0.2 -0.0
Neck or shoulder pain in last month 0.3 0.4 3.0 1.7 0.2 0.3 0.4 0.3 0.2 0.3 0.1 0.1 -0.4 -0.2 -0.2 0.2 -1.1 -0.2 0.1 -0.3 -0.8 0.2 0.6 1.5
Medication: Blood pressure 0.1 0.1 0.6 -0.2 -0.0 0.0 -0.5 -0.0 -0.5 -0.7 -0.0 -0.2 0.3 -0.0 -0.0 0.1 0.2 0.0 0.1 0.0 -0.6 -0.2 -0.0 0.4
Angina (self-reported) 0.2 0.3 1.6 -0.6 0.1 0.5 1.3 0.0 -0.0 0.4 0.5 0.7 0.0 -0.5 -0.4 0.3 -0.4 0.4 0.6 0.1 -0.1 -0.8 -0.4 1.0
Migraine (self-reported) 2.9 3.6 6.4 -1.2 -1.8 -2.0 -1.5 -2.3 -1.8 -0.5 -1.9 -2.5 2.1 2.1 2.1 -1.9 1.9 -2.0 -2.0 -2.0 -2.3 -2.1 -1.8 -1.3
Medication: Ibuprofen 0.5 0.6 2.8 -1.7 -0.8 -0.6 -0.8 -0.6 -0.2 -0.3 -0.6 0.4 0.0 0.6 0.5 -0.9 0.1 -0.3 -0.7 -0.7 -0.4 -0.8 -1.5 -1.3
Medication: Allopurinol 0.2 0.3 1.3 0.9 0.8 0.3 -0.4 0.0 -0.3 0.5 0.3 0.3 -0.5 -0.2 -0.2 0.7 -0.2 0.5 0.3 0.6 -0.2 0.0 0.7 1.2
Medication: Omeprazole 0.9 1.1 3.0 0.9 1.6 1.1 0.7 0.6 -0.3 0.2 1.2 -0.1 -1.1 -1.1 -1.1 1.2 -0.7 1.2 1.1 1.5 0.5 1.0 1.2 1.7
Medication: Seretide 50 evohaler 0.1 0.2 0.9 0.4 0.1 -0.4 0.1 -0.2 0.3 0.9 -0.3 0.1 0.9 0.4 0.4 -0.2 0.3 -0.2 -0.1 -0.1 0.3 0.3 0.1 -0.6
Mean time to correctly identify matches 1.9 3.6 7.3 -2.5 -1.6 -1.9 -1.1 -2.4 -1.4 -0.9 -1.8 -1.8 1.2 1.9 1.9 -2.2 1.8 -1.6 -1.9 -2.3 -1.8 -2.7 -2.1 -2.0
Heart disease (mother) 0.6 0.7 5.4 -0.2 0.8 0.7 0.3 0.7 -0.2 2.3 0.7 1.0 -0.4 -0.7 -0.7 0.8 -0.9 0.9 0.8 0.8 0.8 0.6 0.5 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.5 0.2 -0.9 -0.3 -0.8 -0.2 0.4 0.8 -0.3 -0.7 -0.0 0.2 0.2 -0.6 -0.1 -0.5 -0.3 -1.2 -0.9 -0.8 -1.0 0.3
Whole body fat mass 0.7 2.9 5.9 0.8 1.4 1.8 1.4 1.8 1.1 0.7 1.8 2.1 -1.5 -1.9 -1.9 1.9 -1.7 1.2 2.4 1.7 2.1 1.8 1.9 2.0
Leg fat mass (right) 0.9 3.3 6.0 1.2 1.5 1.8 1.5 1.9 1.1 0.9 1.9 2.1 -1.7 -2.0 -2.0 2.1 -1.9 1.2 2.5 1.8 2.2 1.9 2.2 2.3
Arm predicted mass (right) 0.9 4.4 10.4 2.6 2.1 1.9 2.6 1.8 0.7 0.2 1.8 2.3 -1.8 -1.9 -1.9 2.8 -1.8 1.2 2.2 2.5 0.7 2.6 2.6 3.2
Pulse rate, automated reading 0.1 0.3 1.7 0.4 -0.1 -0.2 -0.7 0.1 1.1 -0.6 -0.2 -0.4 0.5 0.0 0.0 0.1 -0.7 -0.2 0.0 -0.2 1.3 0.4 0.8 0.3
Alcohol intake frequency. 4.8 11.1 16.6 2.3 3.6 3.6 4.1 3.4 2.1 3.3 3.5 3.4 -3.1 -3.6 -3.6 3.7 -3.0 3.6 3.5 3.6 3.2 3.5 3.6 1.7
Comparative height size at age 10 1.6 9.1 18.7 3.4 3.5 3.0 3.1 3.1 2.0 1.2 2.8 3.5 -2.5 -2.8 -2.8 3.8 -1.4 2.7 3.0 3.6 1.9 4.3 3.8 3.0
Number of full sisters 1.1 1.3 3.5 0.4 1.2 1.2 1.1 1.1 1.2 1.6 1.2 1.9 -1.3 -1.1 -1.2 1.1 -0.4 1.2 1.1 1.3 0.5 1.6 1.1 0.2
Suffer from ‘nerves’ 0.1 0.1 1.0 0.2 0.4 -0.0 -0.2 -0.3 -0.1 1.0 0.2 0.5 -0.4 -0.1 -0.0 0.3 -0.3 0.2 0.1 0.5 -0.1 0.4 0.4 -0.0
Overall health rating 0.4 0.9 4.3 -0.2 1.1 0.8 0.2 0.8 2.1 1.0 0.7 1.1 -0.6 -0.9 -0.8 1.0 -1.2 0.8 0.8 0.5 0.6 1.0 1.2 0.8
Chest pain or discomfort 0.8 1.2 4.0 0.8 0.7 1.0 1.7 0.9 0.0 2.0 1.0 1.7 -0.6 -1.0 -0.9 0.8 -1.6 0.6 0.8 -0.1 1.1 0.3 0.9 1.7
Had major operations 0.1 0.1 0.8 0.1 -0.2 -0.1 -0.3 -0.3 -0.8 -0.4 -0.1 -0.1 0.2 0.1 0.1 -0.2 0.0 -0.2 0.2 0.0 -0.7 -0.3 -0.9 -0.4
Age at last live birth 0.2 0.2 1.3 0.7 0.5 0.4 0.5 0.4 0.3 1.1 0.3 0.6 0.3 -0.3 -0.4 0.4 -0.3 0.5 0.1 0.2 0.0 0.5 0.6 0.4
Family relationship satisfaction 1.4 1.8 2.8 1.2 1.5 1.3 1.1 1.5 1.5 1.7 1.3 1.1 -1.1 -1.3 -1.3 1.7 -1.0 1.3 1.4 1.5 0.8 1.6 1.4 0.6
Leg pain on walking 0.8 1.1 4.3 0.3 1.5 0.7 0.2 0.8 2.1 0.8 0.8 0.2 -0.3 -0.7 -0.7 1.1 -0.9 1.2 0.7 0.9 1.4 1.6 1.6 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 3.3 -0.1 0.5 0.7 0.0 0.9 1.3 0.8 0.7 1.8 -0.9 -0.9 -0.9 0.7 -1.1 0.6 0.7 0.5 0.3 0.3 0.3 0.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.0 0.5 0.4 0.9 1.1 0.8 -0.0 0.5 1.0 0.2 -1.0 -1.0 -1.0 0.6 -0.4 0.5 1.1 1.1 1.7 1.1 0.9 0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.6 -0.4 -0.1 -0.1 0.0 -0.2 0.4 -0.8 -0.3 -0.4 0.4 0.1 0.2 0.0 -0.0 -0.1 -0.2 -0.2 -0.2 -0.5 0.2 0.4
Medication: Aspirin 0.1 0.2 0.9 -0.2 -0.5 -0.0 0.5 -0.2 -0.9 -1.0 -0.1 -0.1 -0.0 -0.0 0.0 0.1 0.3 -0.5 0.2 0.1 -1.0 -0.2 -0.3 0.6
Supplements: Vitamin C 0.3 0.3 0.9 -1.0 -0.2 -0.6 -0.2 -0.5 0.4 -0.6 -0.3 -0.1 0.5 0.5 0.5 -0.5 0.4 -0.0 -0.6 -0.8 -0.4 -0.8 -0.9 -0.7
Knee pain experienced in last month 0.2 0.3 1.4 -0.0 0.7 0.1 -0.2 0.4 1.2 0.3 0.1 -0.0 0.6 -0.1 -0.1 0.4 -0.9 0.3 -0.2 -0.1 0.5 0.6 1.0 0.7
Hypertension (Self-reported) 0.1 0.4 2.0 -1.1 -0.5 -0.4 -1.4 -0.1 -0.1 0.2 -0.2 -0.8 0.7 0.2 0.2 -0.4 0.5 -0.2 -0.3 -0.1 0.0 -0.5 -0.8 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 4.6 2.0 1.6 1.8 2.0 1.2 -0.3 1.1 1.8 0.1 -1.4 -1.7 -1.7 1.4 -1.3 1.3 1.8 2.0 1.2 2.0 1.6 2.2
Illnesses of father: Heart disease 0.6 0.8 3.1 -1.2 -0.4 -0.8 -1.1 -0.5 0.4 -1.0 -0.7 -1.0 1.5 0.8 0.8 -0.9 0.7 -0.1 -0.8 -0.8 0.4 -0.4 -0.9 -1.8
Illnesses of siblings: Diabetes 1.8 2.2 4.9 1.3 1.4 1.4 0.6 1.7 2.2 1.1 1.6 1.3 -1.8 -1.5 -1.5 1.4 -2.1 1.5 1.0 1.0 1.8 1.4 1.3 0.8
Smoking status: Previous 0.8 1.2 4.2 -1.8 -0.8 -0.9 -0.9 -0.8 0.9 -1.4 -0.7 -0.6 1.0 0.9 0.9 -1.1 2.1 -0.6 -0.5 -0.9 -1.2 -0.2 -1.5 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.1 -0.8 0.2 0.3 1.1 0.3 0.7 0.6 0.1 0.3 -0.4 -0.2 -0.2 0.1 0.7 0.3 0.1 0.4 -0.8 0.3 -0.7 -0.6
Whole body fat-free mass 0.9 5.0 11.8 2.8 2.0 2.2 2.8 2.2 0.8 0.2 2.0 2.4 -1.8 -2.1 -2.1 2.9 -1.5 1.3 2.7 2.7 0.8 2.8 2.7 3.4
Leg fat-free mass (right) 0.6 3.2 7.1 2.1 1.5 1.7 2.1 1.8 0.7 0.1 1.5 1.9 -1.3 -1.7 -1.7 2.2 -1.2 0.9 2.2 2.1 0.8 2.4 2.4 2.7
Arm fat percentage (left) 0.2 0.8 4.0 -0.1 0.4 0.8 0.5 0.9 0.4 0.7 0.8 0.6 -0.5 -1.0 -1.0 0.8 -1.2 0.4 1.4 0.6 2.0 0.8 1.3 1.2
Average weekly red wine intake 0.9 1.4 2.4 -1.4 -1.2 -1.2 -1.5 -1.1 -1.4 -0.2 -1.3 -1.0 1.0 1.3 1.3 -1.1 0.7 -0.9 -1.4 -0.8 -0.9 -1.5 -1.3 -1.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 -0.4 0.1 0.5 0.0 0.8 0.8 0.0 0.4 0.2 -0.7 -0.5 -0.6 0.2 -0.2 0.3 0.5 0.2 0.4 0.6 0.1 -0.1
Mood swings 0.6 1.1 4.0 -0.2 1.2 1.2 0.0 1.0 1.7 2.0 1.3 -0.6 -1.0 -1.3 -1.3 0.5 -1.3 1.6 0.7 0.2 0.9 0.6 0.5 0.3
Loneliness, isolation 1.5 2.0 5.2 1.0 1.7 1.2 1.4 1.6 2.3 1.6 1.4 0.1 -0.7 -1.4 -1.4 1.4 -1.8 1.6 1.1 0.8 1.7 1.8 1.7 0.6
Long-standing illness, disability or infirmity 1.0 1.6 5.7 -1.8 -0.9 -1.1 -0.5 -1.4 -0.1 -2.4 -1.3 -1.3 1.4 1.2 1.2 -1.2 1.0 -1.3 -1.2 -1.1 -1.7 -0.8 -1.2 0.2
Ever had bowel cancer screening 2.9 3.3 5.3 -1.0 -1.7 -1.9 -0.9 -2.1 -2.3 -2.3 -2.0 -2.0 1.8 2.0 2.0 -1.7 1.3 -2.0 -2.0 -2.2 -1.8 -2.2 -1.7 0.1
Diabetes diagnosed by doctor 2.7 4.4 6.8 1.7 2.1 2.0 2.6 1.9 0.3 1.2 2.2 2.6 -2.4 -2.1 -2.1 2.5 -2.3 1.8 2.3 2.1 2.0 1.9 2.6 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 -0.3 -0.5 -0.3 0.6 0.1 0.3 -0.3 -0.2 -0.1 0.3 0.2 0.2 -0.4 0.0 -0.6 -0.1 -0.3 -0.5 0.1 -0.5 -0.4
Friendships satisfaction 0.6 0.7 5.0 -1.0 0.4 0.3 -0.1 0.6 2.2 1.9 0.3 0.5 -0.2 -0.4 -0.4 0.2 0.4 0.8 0.2 0.2 1.0 0.9 0.2 -1.2
Qualifications: nursing, teaching 0.2 0.3 2.3 -0.8 -0.2 0.2 -0.6 0.6 1.5 0.6 -0.1 0.7 0.2 -0.0 -0.1 0.1 0.2 0.4 -0.2 -0.5 -0.1 -0.4 -0.6 -0.8
Commuting to job workplace: Walk 0.2 0.2 1.4 0.8 0.1 -0.4 -0.9 -0.1 1.2 0.1 -0.3 0.2 0.4 0.5 0.5 -0.0 -0.5 0.1 -0.6 -0.6 0.0 -0.1 -0.0 -0.3
Eye problems/disorders: Cataract 2.4 2.7 7.0 1.3 1.9 1.6 1.9 1.6 0.8 1.3 1.6 0.9 -1.9 -1.6 -1.6 1.8 -2.0 1.4 1.4 1.6 1.2 1.0 2.2 2.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.0 0.7 1.1 1.1 0.1 0.9 0.1 0.1 1.1 0.5 -0.8 -1.2 -1.2 0.9 -1.8 1.2 1.1 1.2 2.0 1.0 1.2 0.4
Medication for cholesterol 0.2 0.4 1.8 -1.1 0.1 -0.6 -1.1 -0.2 1.0 -0.4 -0.6 0.2 0.2 0.6 0.6 -0.2 0.4 0.2 -0.6 -0.6 0.1 -0.2 -0.2 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.5 1.3 0.2 0.5 1.2 0.4 0.1 -1.4 0.6 0.6 -1.2 -0.6 -0.6 0.3 -1.6 0.0 0.7 0.1 0.8 0.5 0.8 1.9
Back pain experienced in last month 0.6 0.8 3.3 -0.1 1.8 0.7 0.4 0.8 0.6 -0.1 1.0 1.0 -1.0 -0.7 -0.7 1.2 -0.2 1.6 0.6 1.1 0.9 0.9 1.0 -0.2
Mineral and other dietary supplements 0.7 1.0 4.9 2.2 0.4 0.8 0.6 0.8 -0.2 1.9 0.7 -0.0 -0.7 -0.7 -0.7 0.8 -1.0 0.2 1.1 0.9 -0.1 0.8 1.0 1.7
Breast cancer (self-reported) 0.8 1.0 2.2 -1.2 -0.5 -1.2 -1.5 -1.2 -0.5 0.1 -1.1 -0.9 0.8 1.2 1.2 -0.9 0.7 -0.7 -1.4 -1.2 -1.0 -0.9 -0.9 -0.5
Asthma (self-reported) 0.3 0.5 2.1 -0.9 -0.7 -0.4 -0.3 -0.3 -1.0 0.7 -0.5 -0.7 0.8 0.4 0.4 -0.8 -0.7 -0.7 -0.5 -1.3 0.5 -1.5 -0.2 0.5
Osteoporosis (self-reported) 0.3 0.4 2.1 -0.0 0.5 0.5 0.4 0.2 -0.4 0.9 0.6 0.3 -0.9 -0.5 -0.5 0.3 0.1 0.9 0.3 0.6 1.5 0.7 0.2 -0.3
Osteoarthritis (self-reported) 0.6 0.8 2.4 -0.2 -0.3 -0.9 -1.4 -0.9 -0.9 -0.3 -0.7 -1.6 1.1 0.9 0.9 -0.5 1.1 -0.7 -1.0 -0.5 -1.2 -0.5 -0.2 -0.5
Medication: Aspirin 0.2 0.2 1.3 0.1 -0.3 0.1 0.6 -0.2 -0.9 -1.1 0.0 0.1 -0.2 -0.1 -0.1 0.2 0.2 -0.3 0.3 0.2 -0.7 -0.1 -0.1 0.8
Medication: Gliclazide 1.3 1.5 3.1 1.1 0.9 1.1 1.2 1.3 1.0 1.2 1.2 1.2 -1.8 -1.2 -1.2 0.9 -1.4 0.9 1.1 0.5 1.5 1.4 1.6 1.2
Illnesses of father: None of the above (group 1) 0.1 0.2 0.5 0.5 0.0 0.3 0.7 0.3 0.2 -0.2 0.1 0.7 -0.6 -0.3 -0.3 0.4 -0.4 0.1 0.1 0.3 0.2 0.2 0.4 0.5
Smoking status: Current 0.2 0.4 1.0 -1.0 0.4 0.9 0.3 0.1 0.6 0.8 0.6 0.2 -1.0 -0.7 -0.7 0.1 -0.5 0.4 0.5 0.5 -0.8 0.2 -0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.6 0.0 0.3 0.4 -0.0 0.7 0.4 -0.3 0.3 -0.4 -0.1 -0.3 -0.4 0.3 -0.4 0.5 0.4 0.1 -0.3 -0.1 -0.3 0.8
Whole body water mass 0.9 5.2 11.6 2.8 2.1 2.2 2.8 2.2 0.8 0.3 2.0 2.4 -1.9 -2.2 -2.2 2.9 -1.6 1.4 2.7 2.7 0.9 2.8 2.8 3.4
Leg predicted mass (right) 0.6 3.3 7.0 2.1 1.6 1.7 2.1 1.9 0.7 0.1 1.5 2.0 -1.3 -1.7 -1.7 2.3 -1.2 0.9 2.2 2.2 0.8 2.5 2.4 2.6
Arm fat mass (left) 0.5 2.2 4.7 0.8 1.1 1.4 1.3 1.4 0.6 0.8 1.4 1.5 -1.2 -1.6 -1.6 1.7 -1.7 0.8 2.0 1.3 2.0 1.5 1.9 2.2
Number of self-reported non-cancer illnesses 2.0 3.4 6.9 -2.6 -1.8 -1.6 -1.9 -2.0 -2.4 -2.3 -1.6 -2.3 1.9 1.7 1.7 -1.8 1.4 -1.7 -1.5 -1.3 -1.5 -2.2 -2.0 -0.7
Average weekly champagne plus white wine intake 2.4 3.4 5.8 -0.6 -2.1 -2.3 -1.9 -1.7 -1.5 -0.6 -2.2 -2.4 2.4 2.2 2.2 -2.1 1.3 -2.2 -1.9 -1.7 -1.2 -1.4 -1.6 -1.3
Miserableness 0.1 0.2 2.6 0.1 0.3 0.0 -0.7 0.4 1.6 0.5 0.2 0.2 -0.4 -0.2 -0.2 0.2 -0.3 0.4 -0.3 -0.5 0.4 0.2 0.2 -0.2
Guilty feelings 0.6 0.9 3.2 0.4 1.1 1.0 1.4 0.9 1.0 1.3 1.0 -0.1 -0.8 -1.0 -1.0 0.7 -1.8 1.2 0.3 0.1 0.7 0.3 0.7 0.9
Wears glasses or contact lenses 0.7 0.8 1.8 1.2 0.6 0.9 1.3 0.6 0.4 0.8 1.0 0.7 -1.4 -1.0 -1.0 0.9 -0.5 0.7 1.0 0.8 1.2 0.9 1.0 0.5
Ever taken oral contraceptive pill 1.8 2.0 3.3 -1.3 -1.7 -1.4 -1.7 -1.0 0.0 -1.6 -1.4 -0.3 1.2 1.3 1.3 -1.6 1.8 -1.3 -1.3 -1.7 -1.1 -1.8 -1.8 -1.5
Hearing aid user 0.7 0.8 2.7 0.0 -0.9 -0.8 -0.5 -1.2 -1.6 -0.8 -0.9 -1.0 0.3 0.7 0.7 -0.6 0.7 -1.2 -0.6 -0.5 -1.6 -0.9 -0.5 0.6
Mother’s age at death 0.6 0.7 3.3 -1.4 -0.4 -0.3 -1.7 -0.3 -0.0 0.2 -0.3 -0.1 0.3 0.3 0.4 -0.8 0.4 0.3 -0.7 -1.3 -0.8 -1.3 -1.8 -0.9
Financial situation satisfaction 1.7 2.1 10.9 0.2 1.5 1.4 1.4 1.5 1.2 3.3 1.5 1.8 -1.2 -1.4 -1.3 1.5 -1.4 1.5 1.4 0.9 0.5 0.9 1.1 1.0
Tinnitus: Yes, now most or all of the time 3.3 3.8 7.6 2.6 1.4 2.1 1.8 1.9 1.5 -0.2 2.3 2.0 -2.8 -2.3 -2.3 1.7 -2.3 1.3 2.4 1.4 1.4 1.5 1.5 2.5
Commuting to job workplace: Public transport 3.3 3.9 6.6 -1.7 -2.1 -2.3 -2.6 -2.2 -1.2 -1.0 -2.1 -0.6 1.5 2.2 2.2 -2.1 2.1 -2.0 -2.2 -2.3 -2.3 -2.1 -2.0 -1.6
Eye problems/disorders: Glaucoma 0.6 0.7 3.6 -0.4 -0.9 -0.8 -0.1 -0.9 -0.4 -0.6 -0.7 -0.5 0.8 0.8 0.8 -0.8 0.9 -0.7 -0.7 -0.5 -0.2 -0.8 -1.2 -1.9
Medication: Blood pressure 0.3 0.7 1.6 0.7 0.8 1.0 0.2 0.7 0.0 0.7 1.1 0.7 -0.9 -1.1 -1.1 0.9 -0.5 0.8 1.1 1.3 0.5 0.6 0.5 0.8
Pain type(s) experienced in last month: Hip pain 1.5 1.8 3.7 0.7 1.7 1.5 1.0 1.5 1.9 0.4 1.4 1.7 -1.3 -1.4 -1.4 1.5 -0.9 1.6 0.9 1.1 0.8 1.9 1.5 1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 4.2 -2.1 0.0 -0.2 -0.3 -0.1 1.1 -1.1 -0.2 0.8 0.0 0.1 0.1 -0.3 0.7 0.4 -0.5 -0.3 0.1 -0.3 -0.8 -1.4
High cholesterol (Self-reported) 2.2 3.9 5.9 -1.7 -2.4 -2.2 -1.5 -2.3 -1.4 -2.0 -2.2 -1.9 2.3 2.1 2.1 -2.0 1.6 -2.2 -2.2 -1.6 -1.1 -1.7 -2.1 -2.3
Medication: Bendroflumethiazide 0.1 0.1 1.0 1.0 -0.3 0.2 -0.1 0.4 -0.1 0.5 0.3 -0.3 -0.4 -0.4 -0.3 0.0 -0.1 -0.2 0.4 0.1 0.3 0.4 -0.1 -0.1
Medication: Paracetamol 0.2 0.2 0.9 -0.7 -0.0 0.4 0.4 0.2 0.9 -0.8 0.3 -0.2 -0.8 -0.4 -0.4 -0.4 0.1 0.4 0.4 -0.0 0.2 0.3 -0.4 -0.8
Medication: Lisinopril 0.5 0.7 2.1 0.3 0.4 0.9 0.4 0.8 -0.4 0.6 1.0 1.4 -1.1 -1.0 -0.9 1.0 -0.9 0.8 0.9 0.9 0.9 0.5 0.7 0.4
Medication: Atorvastatin 0.1 0.1 0.5 -0.0 -0.1 0.4 0.6 0.4 -0.7 0.2 0.5 0.0 -0.3 -0.5 -0.4 0.5 -0.3 0.1 0.3 0.5 0.1 0.4 0.3 0.3
Illnesses of father: High blood pressure 0.6 0.7 2.7 -0.8 -0.8 -0.9 -1.6 -0.6 -1.0 0.9 -0.9 -0.8 1.1 0.9 0.9 -1.0 0.3 -0.8 -0.9 -0.9 -0.1 -0.7 -0.6 -0.4
Alcohol drinker status: Never 0.2 0.3 0.8 -0.2 -0.4 -0.6 -0.6 -0.5 -0.9 -0.4 -0.7 -0.7 0.7 0.5 0.5 -0.4 0.3 -0.5 -0.3 -0.1 -0.3 -0.8 -0.2 -0.6
Ever smoked 0.8 1.3 3.3 -1.5 -1.0 -1.1 -1.1 -1.0 0.8 0.3 -1.0 -0.9 1.1 1.2 1.2 -1.3 1.1 -0.9 -1.2 -1.4 -1.8 -0.8 -1.6 -1.1
Basal metabolic rate 0.9 5.1 11.1 2.5 2.0 2.2 2.6 2.3 0.9 0.4 2.1 2.5 -1.9 -2.2 -2.2 2.9 -1.6 1.4 2.8 2.7 1.2 2.8 2.7 3.3
Leg fat percentage (left) 0.5 1.8 4.6 0.2 1.0 1.3 0.6 1.3 1.0 1.3 1.5 1.6 -1.3 -1.5 -1.5 1.4 -1.6 1.0 1.8 1.2 2.2 1.2 1.5 1.4
Arm fat-free mass (left) 1.3 6.8 14.7 3.1 2.5 2.6 3.1 2.4 0.9 0.7 2.5 2.8 -2.5 -2.6 -2.6 3.3 -2.2 1.8 3.0 2.9 1.3 2.9 3.1 3.8
Number of operations (self-reported) 0.8 1.1 1.9 1.3 1.2 1.2 0.6 1.3 1.2 0.2 1.2 0.7 -1.0 -1.2 -1.2 1.2 -1.1 1.1 1.4 0.8 0.0 1.2 0.9 1.0
Average weekly beer plus cider intake 0.7 1.0 3.4 -0.5 -1.1 -0.8 -0.5 -0.9 -0.3 -1.7 -0.8 0.1 0.1 0.8 0.8 -1.1 0.9 -1.3 -0.8 -1.4 -1.8 -1.1 -1.3 0.7
Irritability 0.1 0.2 1.1 -1.0 -0.5 -0.3 -0.3 -0.3 0.5 -0.2 -0.2 -0.1 0.7 0.3 0.3 -0.6 -0.1 -0.1 -0.3 -0.6 1.1 -0.5 -0.4 -0.4
Risk taking 0.1 0.1 0.6 -0.4 -0.8 -0.1 -0.4 0.2 0.2 0.0 -0.2 0.4 0.0 0.1 0.1 -0.7 0.1 -0.7 -0.1 -0.3 0.1 0.3 -0.3 0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.0 -1.4 -0.1 -0.9 -0.9 -0.8 -0.3 -1.1 -0.8 -0.7 0.3 1.0 1.0 -0.7 1.7 -0.4 -0.6 -0.5 -0.1 -0.2 -0.4 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.5 0.4 1.1 0.7 0.2 1.0 1.0 1.2 0.6 -0.1 -0.5 -0.7 -0.6 0.8 -0.9 0.8 0.4 0.4 -0.0 0.9 0.9 0.8
Age started oral contraceptive pill 0.4 0.6 2.8 -1.0 0.1 -0.8 -0.8 -0.9 -0.3 0.8 -0.7 -0.3 0.8 0.8 0.8 -0.4 0.6 0.0 -1.0 -0.2 -0.3 -0.6 -0.5 -1.7
Diastolic blood pressure, automated reading 0.1 0.4 1.5 -1.1 -0.8 -0.5 -1.0 0.1 1.1 0.1 -0.5 -0.3 0.5 0.3 0.3 -0.4 0.6 -0.4 -0.3 -0.6 0.7 -0.3 -0.6 -1.2
Ever depressed for a whole week 0.1 0.1 0.5 0.4 0.0 0.2 0.1 0.2 -0.7 0.3 0.2 0.5 -0.2 -0.3 -0.3 0.2 -0.6 -0.2 0.1 -0.1 -0.1 -0.0 0.6 0.3
Unable to work because of sickness or disability 0.4 0.5 5.0 -0.5 0.5 0.3 -0.1 0.8 2.2 -0.1 0.3 0.3 -0.1 -0.4 -0.4 0.7 -0.5 0.7 0.0 0.0 1.3 0.8 0.7 -0.8
Commuting to job workplace: Cycle 1.3 1.6 3.4 -1.1 -0.9 -1.5 -1.6 -1.3 -0.5 -0.3 -1.5 -1.7 1.0 1.6 1.6 -1.3 1.1 -1.1 -1.8 -1.1 -0.8 -0.8 -1.1 -1.3
Myopia 0.2 0.3 1.2 -0.5 0.8 0.6 0.2 0.4 -0.7 0.5 0.5 0.9 -0.6 -0.6 -0.6 0.6 -0.0 1.1 0.4 0.6 0.0 -0.4 -0.3 -0.5
Vascular/heart problems diagnosed by doctor 0.1 0.2 1.0 0.9 0.4 0.2 1.0 0.1 -0.1 -0.7 0.1 0.7 -0.3 -0.1 -0.1 0.2 -0.4 0.1 0.0 -0.0 0.2 0.3 0.6 0.5
Cholesterol lowering medication 0.2 0.3 1.3 0.6 -0.5 -0.5 0.2 -0.6 -1.1 0.6 -0.6 -0.9 0.7 0.5 0.5 -0.4 0.1 -0.9 -0.4 -0.4 0.3 -0.3 0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.3 1.2 1.0 0.6 0.4 0.1 -1.0 -0.2 0.6 -1.0 -0.3 -0.5 -0.5 0.8 -0.0 0.6 0.6 1.1 0.1 0.5 0.8 1.5
Pain experienced in last month 0.1 0.2 0.9 0.7 -0.9 -0.1 0.4 -0.3 -1.0 0.3 -0.1 -0.5 -0.1 0.1 0.1 -0.3 -0.0 -0.7 -0.0 -0.1 0.1 -0.5 -0.4 0.8
Supplements: Calcium 3.3 3.6 6.7 -1.2 -1.9 -2.3 -1.4 -2.1 -1.8 -1.9 -2.2 -2.3 2.6 2.2 2.2 -2.0 2.1 -2.0 -2.1 -1.4 -0.7 -1.2 -1.1 -2.1
Basal cell carcinoma (self-reported) 1.1 1.3 3.6 -1.9 -0.7 -1.1 -1.2 -1.4 -1.6 -0.4 -1.1 -0.9 0.8 1.1 1.1 -1.2 0.7 -0.8 -1.2 -0.8 -1.4 -1.6 -1.1 -1.0
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.2 -0.1 0.4 0.8 0.5 0.6 1.5 -0.2 0.8 0.6 -0.8 -0.8 -0.8 0.3 -0.5 0.7 1.0 0.1 -1.1 -0.2 -0.5 0.9
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.5 0.9 0.4 -0.1 0.1 -0.0 1.2 0.1 0.0 -0.3 -0.3 0.0 0.1 0.2 0.7 -0.0 0.0 0.3 -0.7 1.0 0.6 -0.3
Heart disease (siblings) 1.9 2.3 4.2 0.3 2.0 1.9 1.7 1.6 1.3 0.6 1.9 0.5 -2.0 -1.8 -1.8 1.5 -1.0 2.0 1.8 1.3 0.9 1.4 1.1 1.6
Alcohol drinker status: Previous 0.2 0.3 1.2 0.4 0.1 0.4 1.1 0.4 0.4 0.6 0.4 0.9 -0.3 -0.4 -0.4 0.5 -0.5 -0.0 0.3 -0.0 0.6 0.2 0.5 0.9
Pack years of smoking 0.1 0.1 0.5 -0.5 -0.0 -0.3 -0.5 -0.7 -0.5 0.0 -0.3 0.1 0.5 0.4 0.4 -0.2 -0.4 -0.2 -0.5 -0.2 -0.2 -0.3 0.0 0.2
Impedance of whole body 0.2 0.8 3.1 -1.5 -0.8 -0.4 -1.1 -0.4 0.5 0.1 -0.5 -0.2 0.3 0.6 0.6 -1.3 0.6 -0.1 -0.9 -0.9 -0.5 -1.0 -1.8 -1.6
Leg fat mass (left) 0.9 3.6 6.2 1.3 1.6 1.9 1.5 1.9 1.0 0.9 2.0 2.1 -1.8 -2.0 -2.0 2.2 -2.1 1.3 2.5 2.0 2.1 2.0 2.3 2.5
Arm predicted mass (left) 1.1 5.5 11.6 2.8 2.3 2.3 2.6 2.2 1.1 0.5 2.2 2.6 -2.2 -2.3 -2.3 3.1 -1.9 1.6 2.7 2.6 1.1 2.7 2.8 3.4