TWAS hub - CCDC51

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0944	0.0551	0.0041	0.000	NA	-0.005	NA	-0.002	0.340	NA	0.700	NA	0.440
2	TCGA	Thyroid Carcinoma	0.0240	0.0220	0.0054	0.012	0.013	0.006	NA	0.010	0.023	0.017	0.083	NA	0.035

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	7.4	24.0	43.7	6.6	2.1
Osteoporosis (self-reported)	5.7	7.0	12.1	-1.4	-3.5
Waist Hip Ratio (WHR)	5.2	23.2	24.0	4.9	4.7
Pulse rate	5.2	8.7	12.8	3.6	2.1
Hypothyroidism (self reported)	4.9	11.3	12.5	-3.5	-3.2
Friendships satisfaction	4.7	5.8	10.8	-0.9	-3.3
Crohns Disease (2012)	4.5	7.2	13.0	-3.6	-1.2
Ulcerative Colitis (UC)	4.1	7.7	8.6	-2.6	2.9
Ulcerative Colitis	4.1	5.9	7.6	-2.8	2.0
Family relationship satisfaction	4.1	5.0	10.0	-0.2	-3.2
Irritability	3.9	6.6	6.8	-2.5	-2.6
Pack years adult smoking proportion	3.7	5.6	6.0	-2.3	-2.5
Hypothyroidism/myxoedema (self-reported)	3.7	7.3	11.0	-3.3	-1.9
Mouth/teeth dental problems: Loose teeth	3.7	4.4	6.2	1.6	2.5
Serious illness, injury or assault to yourself	3.6	4.4	7.9	-2.8	-0.9
Number of incorrect matches in round	3.6	6.0	12.0	-0.2	-3.5
Illnesses of siblings: Diabetes	3.6	4.4	7.8	-2.8	-1.0
Illnesses of siblings	3.5	4.9	9.7	3.1	-0.3
Pack years of smoking	3.4	5.1	6.6	-2.6	-1.9
Average weekly spirits intake	3.2	4.0	7.9	2.8	0.2
Illnesses of father: High blood pressure	3.2	4.0	6.9	-2.6	1.1
Irritable Bowel Disease (IBD)	3.1	7.4	12.5	-3.5	1.5
Migraine (self-reported)	3.1	3.9	7.5	-0.5	2.7
Blood Eosinophil Count	3.0	23.0	40.0	6.3	2.4
Ever had bowel cancer screening	3.0	3.5	6.9	-2.6	-0.2
Qualifications: nursing, teaching	2.7	4.3	7.7	-0.9	-2.8
Medication: Levothyroxine sodium	2.6	4.4	6.7	-2.6	-1.4
Average weekly beer plus cider intake	2.6	3.8	6.7	2.6	-0.9
Mean Putamen Volume	2.5	2.8	5.6	-0.1	2.4
Father’s age at death	2.5	3.4	3.4	-1.8	1.8
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	7.0	-2.6	-1.1
Lung cancer (father)	2.5	2.9	4.1	-2.0	-1.3
Type 2 Diabetes (T2D) (2012)	2.4	2.7	3.0	1.6	-1.7
Heel T-Score	2.4	19.2	38.3	6.2	0.1
Tense / ‘highly strung’	2.4	4.0	7.9	-0.2	-2.8
Wheeze or whistling in the chest in last year	2.4	4.3	8.5	2.9	-0.2
Depressed Affect (Nagel 2018)	2.3	4.9	7.6	-1.5	-2.8
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	4.1	-1.7	-2.0
Trunk fat percentage	2.2	8.6	16.8	4.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.7	4.1	-1.1	2.0
Hypertension (Self-reported)	2.2	6.0	12.0	-3.5	-0.4
Miserableness	2.2	3.7	7.3	-0.5	-2.7
High blood pressure	2.1	5.9	11.3	-3.4	-0.7
Time employed in main current job	2.1	2.5	4.9	-2.2	0.3
Number of live births	2.1	2.9	5.6	2.4	0.5
Number of full sisters	2.1	2.5	3.5	-1.9	1.2
Bipolar Disorder (2011)	2.0	1.9	3.9	-2.0	0.0
Qualifications: College or University degree	2.0	6.4	10.6	-3.2	-1.5
Knee pain experienced in last month	2.0	3.1	6.1	0.1	2.5
Myopia	2.0	2.9	3.6	-1.5	-1.9
Vascular/heart problems diagnosed by doctor	2.0	5.5	9.6	3.1	1.2
Crohns Disease (2017)	1.9	4.1	8.1	-2.9	-0.4
Frequency of depressed mood in last 2 weeks	1.9	2.6	3.8	-1.2	-1.9
Pain all over the body in last month	1.9	2.1	2.9	-1.7	-1.1
Fluid intelligence score	1.9	3.9	4.5	-2.1	-1.8
Medication: Paracetamol	1.9	2.9	5.7	-0.4	-2.4
Alcohol intake versus 10 years previously	1.8	2.6	3.5	1.9	1.3
Impedance of arm (left)	1.8	8.3	14.7	3.8	1.4
Peak expiratory flow (PEF)	1.8	4.1	6.5	-2.6	1.3
Bipolar Disorder or Schizophrenia	1.7	4.0	5.9	-2.4	-1.5
Depression (Nagel 2018)	1.7	2.6	2.8	-1.6	-1.7
Triglycerides	1.7	2.8	4.6	1.0	2.1
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.9	-2.0	-0.6
Sitting height	1.7	12.2	21.2	4.6	-1.8
Trunk fat mass	1.7	7.3	13.9	3.7	-0.9
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	2.4	-1.5	-1.3
Birth weight of first child	1.7	3.2	6.2	0.4	2.5
Glaucoma (self-reported)	1.7	2.0	3.9	-2.0	0.2
Ever had prostate specific antigen (PSA) test	1.7	1.9	2.3	1.5	1.2
Fractured/broken bones in last 5 years	1.7	2.2	4.2	-2.0	-0.4
Intelligence (Savage-Jansen 2018)	1.6	4.8	9.6	-3.1	-0.3
Major Depression (MDD)	1.6	2.0	2.6	-1.1	-1.6
Falls in the last year	1.6	2.1	4.1	0.3	2.0
Supplements: Vitamin C	1.6	1.8	3.3	1.8	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.7	1.1	1.6
Fasting Glucose	1.5	1.8	3.2	0.7	-1.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.5	1.0	1.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.3	-0.5	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	2.0	-1.4	-1.2
Commuting to job workplace: Car/motor vehicle	1.5	1.8	2.7	0.9	1.6
Mood swings	1.5	2.7	2.7	-1.6	-1.6
Commuting to job workplace: Walk	1.5	1.7	3.0	-0.6	-1.7
Medication: Blood pressure	1.5	2.9	5.2	-2.3	0.8
HbA1C	1.4	1.5	2.2	1.5	0.9
Primary Biliary Cirrhosis	1.4	2.0	3.1	-1.0	1.8
Lung FEV1/FVC ratio	1.4	7.3	14.3	-0.5	3.8
Fed-up feelings	1.4	2.6	5.1	0.0	-2.3
Happiness	1.4	1.6	2.1	-1.4	-1.1
Prospective memory result	1.4	1.8	3.3	1.8	0.4
Body fat percentage	1.4	5.5	10.4	3.2	-0.7
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.1	-0.3	1.8
Ever depressed for a whole week	1.4	1.8	2.7	-1.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.3	-1.8	0.6
Neuroticism (Nagel 2018)	1.3	3.1	5.7	-0.8	-2.4
Lupus	1.3	1.9	3.2	-1.8	0.8
Diabetes (father)	1.3	1.6	3.2	-0.1	1.8
Age when periods started (menarche)	1.3	3.2	3.6	-1.7	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.4	2.3	0.7
Impedance of arm (right)	1.3	6.1	10.8	3.3	1.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.1	-1.0	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	1.8	-1.4	-1.2
Whole body fat mass	1.3	5.5	10.2	3.2	-1.0
Impedance of whole body	1.3	6.6	10.0	3.2	1.8
Schizophrenia (2018)	1.2	2.5	3.8	-1.9	-1.1
Pulse wave Arterial Stiffness index	1.2	1.4	2.7	1.6	0.2
Mean time to correctly identify matches	1.2	2.4	3.6	-1.9	-1.1
Eye problems/disorders: Glaucoma	1.2	1.4	2.8	-1.7	0.2
Reaction Time	1.1	2.1	2.1	-1.5	-1.4
Neuroticism (2016)	1.1	1.6	3.0	-0.3	-1.7
Schizophrenia (2014)	1.1	2.5	3.5	-1.9	-1.2
Cardiovascular Disease	1.1	3.6	7.0	-2.6	-0.4
Supplements: Zinc	1.1	1.2	2.2	-1.5	-0.4
Diabetes (self-reported)	1.1	1.7	3.2	0.4	1.8
Breastfed as a baby	1.1	1.4	2.5	1.6	0.6
Pulse wave peak to peak time	1.1	1.3	2.2	-1.5	-0.5
Medication: Allopurinol	1.1	1.5	2.5	1.6	0.8
Arm fat percentage (left)	1.1	4.4	8.0	2.8	-0.9
Arm fat mass (left)	1.1	4.4	7.7	2.8	-1.1
Number of self-reported non-cancer illnesses	1.1	2.0	3.9	-2.0	-0.1
Ever taken oral contraceptive pill	1.1	1.3	2.0	0.8	-1.4
Mother’s age at death	1.1	1.4	2.3	1.5	0.7
Bipolar Disorder (2018)	1.0	1.6	2.2	-1.5	-1.0
Rheumatoid Arthritis	1.0	1.3	2.6	-1.6	0.3
Blood White Count	1.0	7.1	7.3	2.6	-2.7
Neuroticism	1.0	2.5	4.8	-0.5	-2.2
Gout (self-reported)	1.0	1.3	2.1	1.4	0.7
Medication: Omeprazole	1.0	1.2	2.2	0.4	1.5
Had major operations	1.0	1.1	1.3	-1.0	-1.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.2	1.5	0.3
Loneliness, isolation	1.0	1.4	1.5	-1.1	-1.2
Long-standing illness, disability or infirmity	1.0	1.6	2.4	-1.5	0.9
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.1	0.1	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.5	-0.9	-1.2
Financial situation satisfaction	1.0	1.2	2.2	-0.5	-1.5
Height	0.9	17.2	32.5	5.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	6.0	0.6	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.2	0.7	2.3
Arm fat mass (right)	0.9	3.8	6.6	2.6	-1.0
Blood clot in the leg (DVT)	0.9	1.2	1.4	-1.2	1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	1.5	-0.1
Alzheimer’s Disease (in father)	0.8	0.9	1.7	0.3	1.3
Systolic blood pressure, automated reading	0.8	2.3	4.3	-2.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.1	1.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.3	0.7	-1.2
Arm fat percentage (right)	0.8	3.2	5.3	2.3	-1.0
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.2	-1.8	-0.6
Medication: Lansoprazole	0.8	0.9	1.8	1.3	-0.3
Medication: Paracetamol	0.8	1.3	2.4	-0.6	-1.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.9	1.4	0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-0.2	1.3
Breast cancer (self-reported)	0.8	0.9	1.0	1.0	0.9
Unable to work because of sickness or disability	0.8	1.0	1.4	-1.2	0.8
Heart disease (siblings)	0.8	1.0	1.6	-1.2	-0.7
Smoking Status	0.7	1.7	3.2	-1.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	1.2	0.6
Leg fat-free mass (left)	0.7	3.7	4.6	2.1	-1.7
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	1.3	-0.2
Waist circumference	0.7	2.7	4.7	2.2	0.8
Weight	0.7	3.4	5.6	2.4	-1.1
Standing height	0.7	7.3	14.4	3.8	-0.4
Number of full brothers	0.7	0.9	1.6	-1.3	-0.4
Worry too long after embarrassment	0.7	1.3	2.4	1.6	0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.5	1.2	-0.4
Leg fat mass (right)	0.7	2.7	4.8	2.2	-0.8
High cholesterol (Self-reported)	0.7	1.3	1.7	-0.9	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.5	-1.6	-0.6
BMI	0.6	3.5	4.4	1.6	-2.1
Relative age voice broke	0.6	1.0	1.8	-0.4	-1.3
Qualifications: CSEs or equivalent	0.6	0.8	1.1	-1.1	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.4	0.2	-1.5
Medication: Atenolol	0.6	0.8	0.9	0.8	1.0
High blood pressure (mother)	0.6	0.9	1.6	-1.2	0.4
Leg predicted mass (left)	0.6	3.3	4.0	2.0	-1.6
Hair/balding pattern: Pattern 2	0.6	0.7	1.3	0.4	1.1
Medication: Ramipril	0.6	0.8	1.7	-1.3	0.0
Worrier / anxious feelings	0.6	1.0	2.0	-0.3	-1.4
Depression (self-reported)	0.6	0.8	1.5	-1.2	0.1
Medication: Ibuprofen	0.6	0.7	0.9	-1.0	-0.6
Comparative height size at age 10	0.6	3.3	6.5	2.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.3	1.2	0.5
Eye problems/disorders: Cataract	0.6	0.7	1.2	-1.1	0.5
Back pain experienced in last month	0.6	0.9	1.3	0.7	1.1
Alcohol drinker status: Never	0.6	0.7	1.3	0.4	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-1.0	-0.6
Leg fat mass (left)	0.6	2.4	4.2	2.0	-0.8
Breast Cancer	0.5	1.2	1.4	-1.2	1.0
Prostate Cancer	0.5	0.7	0.8	-0.9	-0.8
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-0.0	-1.2
Lung FVC	0.5	2.6	5.0	0.4	2.2
Sensitivity / hurt feelings	0.5	0.9	1.3	1.1	0.7
Hearing difficulty/problems: Yes	0.5	0.7	1.3	1.1	-0.3
Medication for hormone replacement therapy	0.5	0.6	1.1	1.1	-0.3
Medication: Metformin	0.5	0.7	0.8	0.9	0.8
Severe depression (siblings)	0.5	0.5	1.0	-1.0	0.3
Impedance of leg (right)	0.5	2.4	2.7	1.6	1.5
Hand grip strength (right)	0.5	1.2	2.0	1.4	-0.7
Impedance of leg (left)	0.5	2.2	2.9	1.3	1.7
Heart attack	0.5	0.6	1.1	-1.1	-0.4
Neuroticism score	0.5	1.1	2.1	0.3	-1.4
Hair/balding pattern: Pattern 4	0.5	1.3	2.4	1.6	-0.5
Loud music exposure frequency	0.5	0.5	1.0	0.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	0.5	-0.9
Health satisfaction	0.5	0.6	1.2	0.1	-1.1
Shortness of breath walking on level ground	0.5	0.7	0.9	0.9	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	1.2	0.5
Alcohol intake frequency.	0.5	1.3	2.5	-0.0	1.6
Leg pain on walking	0.5	0.6	1.1	0.2	1.1
Medication: Aspirin	0.5	0.6	0.8	-0.7	0.9
Leg fat-free mass (right)	0.5	2.5	2.8	1.7	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.6	0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	0.0	1.5
Leg predicted mass (right)	0.5	2.6	2.9	1.7	-1.5
Medication: Lisinopril	0.5	0.7	1.1	-1.1	0.4
Arm fat-free mass (left)	0.5	2.4	4.8	0.3	-2.2
Number of operations (self-reported)	0.5	0.7	1.1	-0.6	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.9	0.2
LDL Cholesterol	0.4	0.7	1.2	-0.4	1.1
Blood Platelet Count	0.4	4.5	9.0	0.1	3.0
Chronotype (morning person)	0.4	0.9	1.7	-0.1	-1.3
Hand grip strength (left)	0.4	0.9	1.0	1.0	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	1.0	-0.2
Townsend deprivation index at recruitment	0.4	0.6	0.8	-0.9	-0.6
Taking other prescription medications	0.4	0.7	1.3	-0.3	-1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.3	0.2	-1.1
Mouth/teeth dental problems	0.4	0.6	1.1	-0.3	-1.1
Exposure to tobacco smoke at home	0.4	0.5	0.6	-0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	-0.9	-0.7
High blood pressure (siblings)	0.4	0.5	0.6	-0.8	0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	1.7	1.1	1.3
Comparative body size at age 10	0.4	1.0	2.0	-0.3	1.4
Eye problems/disorders: None of the above	0.4	0.5	0.5	0.7	-0.7
Emphysema/chronic bronchitis	0.4	0.4	0.8	0.3	0.9
Arm predicted mass (right)	0.4	2.0	2.9	1.0	-1.7
Diabetes diagnosed by doctor	0.4	0.7	1.2	0.4	1.1
Medication: Aspirin	0.4	0.6	0.6	-0.7	0.8
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.1	-1.0
Basal metabolic rate	0.4	2.2	2.5	1.4	-1.6
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.3	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-1.0	-0.4
Alcohol drinker status: Previous	0.4	0.4	0.9	-0.1	0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	0.5	0.7	0.7
Ovarian Cancer	0.3	0.5	0.6	-0.8	-0.6
HDL Cholesterol	0.3	0.6	1.0	-1.0	0.3
Systolic Blood Pressure	0.3	1.7	3.5	-1.9	-0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.2	-0.7
Angina	0.3	0.4	0.8	0.9	0.0
Average weekly fortified wine intake	0.3	0.3	0.6	0.0	-0.8
Supplements: Glucosamine	0.3	0.4	0.7	0.9	-0.1
Nervous feelings	0.3	0.5	0.9	1.0	0.3
Forced vital capacity (FVC)	0.3	1.1	1.1	1.0	1.0
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.3	0.8
Medication: Simvastatin	0.3	0.5	0.9	-0.2	1.0
Hip circumference	0.3	1.1	2.1	0.3	-1.4
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.2	0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	0.8	0.6
Illnesses of mother	0.3	0.4	0.8	0.2	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	-1.0	-0.1
Medication: Amlodipine	0.3	0.5	1.0	-0.0	1.0
Arm fat-free mass (right)	0.3	1.7	2.8	0.9	-1.7
Smoking status: Previous	0.3	0.4	0.9	-0.1	0.9
Whole body fat-free mass	0.3	1.7	2.7	0.9	-1.6
Asthma (self-reported)	0.3	0.6	1.0	1.0	0.3
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.4	0.8
Whole body water mass	0.3	1.9	2.9	1.0	-1.7
Wears glasses or contact lenses	0.3	0.4	0.7	0.1	-0.8
Hearing aid user	0.3	0.4	0.4	-0.6	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.2	0.9
Risk taking	0.3	0.4	0.9	-0.2	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.1	0.9
Worry (Nagel 2018)	0.2	0.5	1.0	0.0	-1.0
Allergy or Eczema	0.2	0.5	0.7	-0.6	-0.8
Maternal smoking around birth	0.2	0.3	0.6	0.2	0.8
Multivitamins +/- minerals	0.2	0.2	0.3	-0.4	0.6
Body mass index (BMI)	0.2	0.9	0.9	0.9	-0.9
Alcohol usually taken with meals	0.2	0.3	0.6	0.1	0.8
Had other major operations	0.2	0.2	0.3	-0.6	-0.4
Trunk fat-free mass	0.2	1.0	2.0	0.3	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.7	-0.3
Trunk predicted mass	0.2	1.1	2.2	0.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.2	-0.8
Headache pain in last month	0.2	0.4	0.7	0.2	0.8
Birth weight	0.2	0.4	0.8	-0.9	-0.0
Leg fat percentage (right)	0.2	0.9	1.6	1.3	-0.4
Angina (self-reported)	0.2	0.3	0.6	0.8	0.0
Heart disease (mother)	0.2	0.3	0.4	-0.4	0.6
Suffer from ‘nerves’	0.2	0.3	0.5	0.7	-0.2
Age at last live birth	0.2	0.4	0.7	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.2	0.6
Guilty feelings	0.2	0.3	0.3	0.5	0.6
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.3	0.6	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.7	-0.2
Leg fat percentage (left)	0.2	0.7	1.2	1.1	-0.3
Age started oral contraceptive pill	0.2	0.2	0.4	0.7	-0.2
Cholesterol lowering medication	0.2	0.3	0.4	-0.6	0.6
Pain experienced in last month	0.2	0.4	0.7	-0.4	-0.8
Supplements: Calcium	0.2	0.2	0.2	-0.5	-0.3
Arm predicted mass (left)	0.2	1.1	2.1	0.4	-1.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.4	0.1
Blood Red Count	0.1	1.0	2.0	1.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.0	0.6
Tanning	0.1	0.8	1.1	0.7	1.1
Number of treatments/medications taken	0.1	0.2	0.3	0.3	-0.6
Relative age of first facial hair	0.1	0.3	0.4	-0.6	-0.3
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	-0.1
Diabetes (mother)	0.1	0.2	0.3	0.5	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	-0.6
Had menopause	0.1	0.1	0.1	-0.1	0.4
Qualifications: None of the above	0.1	0.3	0.5	0.3	0.7
Allergy	0.1	0.1	0.3	0.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Asthma	0.1	0.3	0.5	0.7	0.2
Medication: Cholesterol lowering	0.1	0.2	0.3	0.3	0.5
Length of working week for main job	0.1	0.1	0.1	0.3	0.3
Pulse wave reflection index	0.1	0.1	0.1	-0.3	-0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	0.1
Overall health rating	0.1	0.2	0.4	0.6	0.3
Chest pain or discomfort	0.1	0.2	0.4	-0.1	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.5	0.2
Medication for cholesterol	0.1	0.2	0.4	0.2	-0.6
Mineral and other dietary supplements	0.1	0.1	0.1	-0.2	-0.4
Medication: Atorvastatin	0.1	0.1	0.1	-0.4	0.3
Ever smoked	0.1	0.1	0.2	-0.2	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.3	-0.7
Age at First Birth	0.0	0.1	0.1	0.1	0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.1	-0.0
Respiratory disease	0.0	0.1	0.1	0.2	0.3
Hair Pigment	0.0	0.4	0.6	-0.5	0.8
Medication: Co-codamol	0.0	0.1	0.1	-0.2	-0.3
Current tobacco smoking	0.0	0.1	0.1	-0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.3	0.1
Past tobacco smoking	0.0	0.1	0.1	0.2	-0.4
Noisy workplace	0.0	0.1	0.1	0.0	-0.3
Number of children fathered	0.0	0.0	0.1	-0.2	0.2
Age at first live birth	0.0	0.0	0.1	-0.2	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	-0.1
Medication: Blood pressure	0.0	0.0	0.0	-0.1	0.1
Average weekly red wine intake	0.0	0.0	0.0	-0.0	-0.2
Medication: Gliclazide	0.0	0.0	0.0	0.1	-0.0
Smoking status: Current	0.0	0.1	0.1	-0.1	-0.3

Hub : Genes

CCDC51

Models

Trait associations