TWAS hub - CCDC69

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0310	0.00390	-0.001	0.025	0.033	0.024	0.017	3.8e-01	0.00047	5.6e-05	6.3e-04	3.4e-03
2	GTEx	Whole Blood	0.1270	0.0480	0.00640	0.025	NA	0.040	NA	0.019	2.1e-03	NA	1.3e-04	NA	6.5e-03
3	METSIM	Adipose	0.1006	0.0387	0.00190	0.009	0.019	0.071	0.028	0.024	1.2e-02	0.00054	8.3e-11	3.6e-05	1.3e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0823	0.0302	0.00410	0.069	0.021	0.052	0.061	0.056	3.4e-09	0.00097	2.9e-07	2.9e-08	9.8e-08
5	TCGA	Breast Invasive Carcinoma	0.0435	0.0167	0.00018	0.009	0.015	0.005	NA	0.007	3.7e-03	0.00032	2.7e-02	NA	1.4e-02
6	TCGA	Brain Lower Grade Glioma	0.0639	0.0334	0.00630	-0.001	0.009	0.006	NA	-0.001	5.2e-01	0.02600	6.5e-02	NA	3.8e-01
7	TCGA	Testicular Germ Cell Tumors	0.1630	0.0740	0.00940	0.016	0.044	0.014	NA	0.041	8.9e-02	0.01100	1.0e-01	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FEV1/FVC ratio	4.9	24.8	59.1	-1.4	6.9	2.5	-7.7	-0.6	-6.4	-4.1
Had major operations	3.2	3.7	11.2	-2.0	0.1	-2.8	-0.7	1.5	-0.5	-3.3
Chronic bronchitis/emphysema (mother)	2.4	2.8	7.8	2.8	-2.4	0.9	1.6	0.6	1.5	0.6
Loud music exposure frequency	2.3	2.5	8.3	2.9	-1.4	2.4	0.4	0.1	0.3	1.2
Tinnitus: Yes, now most or all of the time	2.1	2.5	8.3	-2.1	2.9	-1.7	-0.5	-0.4	-1.2	-0.2
Qualifications: CSEs or equivalent	1.8	2.4	7.1	1.8	0.2	0.8	-1.4	-1.9	0.2	2.7
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	22.4	-1.3	3.0	1.5	-4.7	-1.4	-2.1	-0.5
Family relationship satisfaction	1.8	2.2	6.5	0.9	-0.6	1.3	-0.5	1.8	1.6	-2.5
Hearing aid user	1.8	2.1	6.5	-2.3	1.2	-0.5	-0.0	-0.1	-1.0	-2.5
Medication: Seretide 50 evohaler	1.7	2.0	9.0	0.3	-3.0	1.6	-0.8	0.1	1.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.9	-1.8	1.4	-1.1	-2.4	-0.5	-1.2	-0.3
Lupus	1.6	2.5	12.0	0.0	-3.5	0.5	0.9	0.1	0.2	2.1
Neuroticism (2016)	1.6	2.3	8.1	-1.0	0.8	1.4	-2.9	-0.4	-2.0	-0.4
Diabetes (mother)	1.6	2.0	5.9	-0.9	1.1	-0.8	1.7	-1.5	-0.4	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	16.9	-0.8	3.3	1.7	-4.1	-0.4	-1.4	-1.2
Illnesses of father: Heart disease	1.6	2.2	6.8	0.7	0.0	-0.3	-1.9	-1.4	-1.5	2.6
Ever had hysterectomy (womb removed)	1.5	1.7	3.8	0.9	-1.9	-0.8	1.9	1.3	1.0	0.6
Severe depression (siblings)	1.5	1.7	5.0	-2.2	1.3	-0.4	-0.8	0.4	-1.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.3	0.2	1.5	-1.1	2.5	-0.4	0.1	1.5
Peak expiratory flow (PEF)	1.5	3.4	9.7	-1.5	2.3	0.7	-3.1	-1.3	-1.6	1.2
Coronary Artery Disease (CAD)	1.4	1.6	3.2	1.7	0.2	1.7	-1.8	-0.2	-1.0	1.3
Primary Biliary Cirrhosis	1.4	2.0	9.4	3.1	-1.1	0.5	-0.7	-0.1	1.4	1.0
Supplements: Glucosamine	1.4	1.9	5.7	-0.7	-1.6	-2.4	0.4	-0.2	0.1	-2.0
Time employed in main current job	1.4	1.6	7.1	-0.1	1.3	-2.7	1.4	-0.5	0.6	0.1
Emphysema/chronic bronchitis	1.4	1.5	6.5	0.1	-0.8	2.6	-1.0	1.3	0.2	0.9
Medication: Aspirin	1.4	1.9	6.3	-0.6	-0.3	0.3	0.2	2.5	-1.2	-2.2
Alcohol drinker status: Previous	1.4	1.6	5.0	1.6	-2.2	0.9	-0.4	0.9	1.3	0.1
Mean Putamen Volume	1.3	1.5	4.0	-2.0	1.8	0.1	-0.4	-0.1	-0.8	-1.6
Chest pain or discomfort	1.3	1.9	4.6	0.9	-1.1	1.8	-1.4	0.3	-1.3	2.1
Loneliness, isolation	1.3	1.8	6.1	-0.6	0.6	-0.2	-2.5	-0.4	-1.2	-2.0
Osteoporosis (self-reported)	1.3	1.6	3.1	1.5	-1.3	0.1	1.5	1.4	1.8	0.2
Alzheimer’s Disease (in father)	1.2	1.3	3.3	-1.6	0.2	-1.8	0.2	-0.1	-0.5	-1.7
HDL Cholesterol	1.2	1.9	5.4	-1.7	2.3	-1.5	-0.4	-1.4	-0.9	0.5
Had other major operations	1.2	1.4	4.4	-0.2	1.0	-1.2	-0.9	-0.4	-1.5	-2.1
Medication: Simvastatin	1.2	1.7	4.2	1.7	-0.7	1.8	-0.3	2.1	-0.6	-1.0
Exposure to tobacco smoke at home	1.2	1.4	4.3	-0.6	0.0	0.7	-2.1	-0.1	-0.6	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	6.0	-0.1	0.5	0.0	1.4	2.4	-0.6	-1.3
Eye problems/disorders: None of the above	1.2	1.4	3.2	0.8	0.6	1.1	-1.0	-0.6	-1.8	1.7
Financial situation satisfaction	1.2	1.5	3.6	-1.1	0.7	1.4	-1.9	1.2	-0.1	-1.4
Number of operations (self-reported)	1.2	1.8	4.0	-1.6	-0.2	-1.4	-1.3	0.3	-1.4	-2.0
Ulcerative Colitis (UC)	1.1	2.0	5.2	-1.5	1.1	-0.1	-2.3	-2.1	-0.6	-0.5
Ovarian Cancer	1.1	1.5	3.1	-0.3	0.4	1.1	-1.3	1.5	-1.3	-1.8
Fasting Glucose	1.1	1.3	5.6	-1.1	0.4	0.4	0.1	1.3	0.4	-2.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.1	0.8	-0.9	1.4	0.6	0.8	1.8	1.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.3	-0.9	-0.4	1.0	1.3	1.3	1.5	-1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.4	0.8	1.1	1.9	0.5	0.6	1.4	1.5
Health satisfaction	1.1	1.4	4.0	-2.0	1.4	-0.0	0.8	1.0	-0.2	-1.5
Medication: Blood pressure	1.1	1.9	5.2	0.4	0.0	-1.7	-0.9	-0.7	-1.9	-2.3
Medication: Aspirin	1.1	1.4	5.5	-0.7	-0.2	-0.2	0.2	2.3	-1.1	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.8	1.8	1.1	2.2	-1.5	-0.5	-0.0	-0.1
Back pain experienced in last month	1.1	1.6	3.3	0.8	1.5	1.6	-1.8	0.8	0.1	-1.5
Breast cancer (self-reported)	1.1	1.3	7.5	-0.0	0.3	-0.9	2.7	0.6	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	8.7	-0.6	1.4	1.4	-3.0	-1.4	-1.0	-1.1
Mother’s age at death	1.1	1.4	6.7	-0.5	0.8	-0.9	0.2	0.9	0.8	-2.6
Medication for hormone replacement therapy	1.0	1.1	3.0	0.7	-0.7	1.6	-0.8	1.7	-0.1	-0.5
Average weekly fortified wine intake	1.0	1.2	3.2	-1.6	-0.5	0.1	-1.1	-0.2	-0.9	-1.8
Multivitamins +/- minerals	1.0	1.3	4.4	-1.0	-1.0	-2.1	0.4	-1.1	-0.6	-0.9
Nervous feelings	1.0	1.9	9.6	3.1	-1.1	1.0	-0.4	0.3	-1.0	-0.4
Happiness	1.0	1.2	3.9	-0.1	-0.1	0.4	-0.1	1.8	2.0	-1.0
Wheeze or whistling in the chest in last year	1.0	1.8	6.4	1.5	-0.6	1.1	1.3	-0.1	0.7	2.5
Angina (self-reported)	1.0	1.3	4.3	0.6	0.5	0.4	-0.5	2.1	-1.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.9	0.1	-0.9	2.0	0.4	0.9	0.3	1.6
Alcohol intake frequency.	1.0	2.3	10.8	3.3	-1.1	0.9	-1.3	-0.6	1.0	0.5
Knee pain experienced in last month	1.0	1.6	6.5	1.2	-0.5	-1.7	2.5	0.5	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	6.4	-2.5	1.1	0.8	-1.3	-1.3	-1.4	1.1
Eye problems/disorders: Cataract	1.0	1.2	2.7	-1.6	1.0	-1.3	1.0	-0.4	0.6	-1.3
Mineral and other dietary supplements	1.0	1.3	3.7	-0.6	1.9	-0.3	-1.0	-1.2	-1.3	1.2
HbA1C	0.9	1.0	2.5	-1.6	-1.5	0.8	-0.6	0.8	-0.5	0.3
Angina	0.9	1.2	4.3	0.8	0.2	0.3	-0.4	2.1	-1.5	-0.8
Supplements: Zinc	0.9	0.9	2.1	0.4	-0.8	1.5	-1.1	-0.5	-1.4	-0.4
Fed-up feelings	0.9	1.7	4.5	-0.5	1.2	1.3	-0.5	2.1	0.1	-1.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.9	0.6	1.2	1.0	0.2	-1.7	1.0	0.6
Medication: Atenolol	0.9	1.2	3.1	1.2	-1.7	-1.8	0.6	0.4	-0.2	0.1
Financial difficulties in last 2 years	0.9	1.2	3.3	-0.2	0.6	0.8	-1.8	0.2	-1.6	-1.2
Alcohol intake versus 10 years previously	0.9	1.4	3.5	0.8	1.5	0.3	-0.7	-1.2	-1.9	-1.0
Asthma	0.9	1.7	4.3	0.4	0.3	1.4	2.1	1.4	0.9	1.7
Length of working week for main job	0.9	1.0	2.8	-1.2	-0.8	-1.0	0.3	-0.8	0.5	-1.7
Hair/balding pattern: Pattern 4	0.9	2.2	6.9	-2.6	1.7	-0.2	-1.8	-0.8	-0.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.5	0.3	-0.3	0.8	0.7	-0.5	2.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	6.3	-1.0	-0.6	-0.8	-2.5	-0.3	-0.1	0.1
Heart disease (mother)	0.9	1.2	3.7	-1.4	1.9	1.0	-0.4	0.1	-0.5	-1.1
Suffer from ‘nerves’	0.9	1.5	6.3	-0.3	1.1	2.5	-0.3	0.1	-1.6	-0.2
Leg pain on walking	0.9	1.1	3.1	0.9	-0.4	-1.8	1.7	0.4	0.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.1	1.8	-0.1	0.0	-1.0	-0.1	-0.9	1.6
Smoking status: Previous	0.9	1.3	3.1	-1.1	-1.8	1.2	0.7	1.1	1.4	0.2
Mood swings	0.9	1.6	4.9	-0.5	0.5	1.6	-2.2	-1.1	-1.1	-0.9
Friendships satisfaction	0.9	1.1	2.5	0.5	0.3	1.0	0.7	1.4	1.3	-1.6
Asthma (self-reported)	0.9	1.7	4.9	0.4	0.8	1.2	2.2	1.4	0.7	1.7
Smoking status: Current	0.9	1.4	4.7	-1.4	0.9	-0.4	-2.2	-0.7	-1.1	0.4
Wears glasses or contact lenses	0.9	1.0	3.2	-0.1	-1.1	1.3	-0.4	-0.4	1.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.3	1.0	-1.8	0.6	-0.1	0.3	0.5	-1.8
Fractured/broken bones in last 5 years	0.9	1.2	3.8	1.6	-0.3	2.0	0.6	1.0	0.7	-0.1
Crohns Disease (2017)	0.8	1.8	8.6	0.0	-0.3	1.9	-0.4	-0.6	0.1	2.9
Reaction Time	0.8	1.5	4.4	0.8	1.2	0.9	-0.6	2.1	-1.0	-1.3
Blood White Count	0.8	6.3	30.1	-0.3	0.9	-0.1	-5.5	-0.9	-2.7	-2.2
Hearing difficulty/problems: Yes	0.8	1.3	4.3	-1.0	0.7	-1.6	-0.3	0.2	-0.8	-2.1
Current tobacco smoking	0.8	1.3	4.2	-1.4	0.5	-0.6	-2.0	-1.1	-1.0	0.3
Relative age voice broke	0.8	1.2	5.9	-0.4	0.1	1.4	-0.2	0.0	0.3	2.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.8	1.9	0.2	-0.8	1.2	-0.2	0.4	-0.6
Number of incorrect matches in round	0.8	1.3	4.9	1.2	-1.0	2.2	-0.4	0.2	1.1	0.4
Heart attack	0.8	1.0	3.8	-0.7	-0.5	-0.3	0.2	1.9	-1.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	6.5	0.6	-0.1	0.5	0.6	-0.3	0.0	2.5
Falls in the last year	0.8	1.1	3.2	1.8	-0.8	0.9	-0.3	1.0	1.0	-0.9
Number of live births	0.8	1.1	2.8	0.4	-0.4	-1.1	-1.5	-0.4	-1.7	-1.0
Depression (self-reported)	0.8	0.9	2.5	-1.6	0.6	-0.5	-0.9	-1.0	-1.1	0.5
Pulse wave Arterial Stiffness index	0.8	1.0	3.3	-0.8	1.0	-0.9	1.8	0.8	-0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.1	-1.1	0.4	1.5	-0.9	1.8	-0.4	-0.2
Birth weight	0.8	1.7	4.2	-2.1	1.2	-0.9	0.8	1.5	-0.4	-1.5
Exposure to tobacco smoke outside home	0.8	1.0	5.4	-0.2	1.2	0.5	-0.4	0.1	-2.3	0.1
Pulse wave peak to peak time	0.8	1.0	3.4	0.9	-1.2	0.9	-1.8	-0.5	0.2	0.2
Overall health rating	0.8	1.7	3.9	1.4	-0.4	2.0	-0.1	0.8	-1.3	1.9
Long-standing illness, disability or infirmity	0.8	1.3	5.3	-0.4	-0.3	0.7	1.4	2.3	-0.4	-0.9
Ever taken oral contraceptive pill	0.8	0.9	3.4	0.1	0.8	-0.4	-1.9	-0.9	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.7	0.0	-1.9	0.5	0.0	1.2	-0.8	-0.9
Ever depressed for a whole week	0.8	1.0	4.1	-1.4	0.3	0.6	-0.6	2.0	0.4	-0.5
Cholesterol lowering medication	0.8	1.2	2.9	0.7	-0.7	1.7	-0.8	1.4	-0.9	-1.1
Basal cell carcinoma (self-reported)	0.8	0.9	2.6	1.6	-0.0	0.6	-1.1	0.6	-0.0	-1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.5	-0.9	0.1	-0.6	0.1	1.9	-1.5	-0.5
Alzheimer’s Disease (in mother)	0.7	0.8	2.2	1.5	-1.3	0.6	1.0	0.3	0.3	0.4
Ulcerative Colitis	0.7	1.0	5.4	0.0	-0.5	-0.0	-0.9	-2.3	-0.1	0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.4	1.9	-1.6	-0.1	0.6	0.7	1.0	-1.1
Lung FVC	0.7	3.7	12.9	0.1	2.1	1.5	-3.6	-0.1	0.0	-2.4
Average weekly spirits intake	0.7	0.9	2.2	0.4	0.5	-1.5	1.1	-0.9	1.1	0.4
Relative age of first facial hair	0.7	1.5	9.1	0.4	0.0	0.8	0.5	-0.5	0.4	3.0
Hand grip strength (right)	0.7	1.9	5.2	-2.3	1.4	-2.3	0.6	-0.9	-0.5	-0.1
Townsend deprivation index at recruitment	0.7	1.0	6.0	-0.5	0.4	0.3	-0.4	-0.3	-2.4	0.4
Maternal smoking around birth	0.7	1.0	5.7	2.4	-0.6	0.8	-0.3	0.3	0.2	0.6
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.3	-0.6	-0.7	0.2	-0.1	-0.4	-1.7	2.5
Chronic bronchitis/emphysema (father)	0.7	0.8	4.6	-0.3	0.0	-0.2	2.1	0.3	0.4	0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.1	-1.4	-0.2	0.5	1.5	1.3	0.1	0.6
Medication: Ramipril	0.7	0.9	3.1	-0.6	0.4	-1.8	0.7	0.1	-0.5	-1.3
Fluid intelligence score	0.7	1.5	4.4	-1.4	0.4	-1.6	0.1	-0.9	-2.1	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	6.2	-2.5	-0.4	-1.0	-1.2	-0.0	-0.4	-1.2
Medication: Cholesterol lowering	0.7	1.1	3.6	0.5	-0.5	1.2	0.9	1.9	-0.8	-0.3
Tense / ‘highly strung’	0.7	1.1	3.5	-1.9	0.3	-0.9	0.0	0.1	-1.3	-1.2
Number of full brothers	0.7	0.9	3.5	-0.8	-1.2	0.4	-0.0	0.7	0.1	-1.9
Migraine (self-reported)	0.7	0.9	2.7	-0.7	0.2	-1.1	-0.9	-0.9	-1.7	0.3
Medication: Omeprazole	0.7	0.8	2.4	-0.5	-1.3	0.1	-1.5	-1.0	0.3	0.5
Mean time to correctly identify matches	0.7	1.4	4.1	1.7	0.8	0.3	0.4	2.0	-0.8	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.9	0.4	-0.4	1.2	-0.9	1.0	-1.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	0.3	0.3	1.6	-0.7	1.2	-1.0	-0.5
Commuting to job workplace: Cycle	0.7	0.8	4.2	-0.0	-0.1	-0.2	-0.7	0.9	0.3	-2.1
Bipolar Disorder (2018)	0.6	0.9	2.2	0.1	-0.6	1.3	-1.0	-0.6	-0.9	1.5
Depression (Nagel 2018)	0.6	1.0	2.5	1.0	-0.3	0.7	-1.3	0.9	-0.6	-1.6
Irritable Bowel Disease (IBD)	0.6	1.5	3.4	-1.1	0.7	0.8	-1.4	-1.8	-0.3	1.7
Major Depression (MDD)	0.6	0.7	3.5	0.4	0.1	0.6	-0.1	0.7	0.3	-1.9
Age at First Birth	0.6	0.9	2.7	0.0	0.3	1.6	-0.2	0.2	0.9	-1.6
Crohns Disease (2012)	0.6	0.9	3.4	0.3	-1.3	1.0	0.4	0.4	-0.3	1.8
LDL Cholesterol	0.6	0.9	2.6	-1.6	0.3	-1.4	-0.8	-0.8	-0.3	-0.6
Hand grip strength (left)	0.6	1.5	3.5	-1.9	1.8	-1.6	0.6	-0.2	-0.2	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.9	-0.4	0.4	0.8	-1.7	0.5	-1.1	-1.0
Medication: Co-codamol	0.6	0.7	1.8	0.5	-1.3	0.5	-0.9	-1.3	-0.6	-0.2
Taking other prescription medications	0.6	0.9	2.4	-0.8	-1.5	0.3	0.8	0.8	-1.3	-0.4
High blood pressure	0.6	1.6	7.3	1.4	0.3	-2.7	-0.7	-0.7	-0.7	-0.5
Stomach or abdominal pain in last month	0.6	0.8	2.9	0.3	-0.7	-1.7	-0.2	0.1	0.6	-1.3
Past tobacco smoking	0.6	1.2	2.2	1.5	1.3	-0.5	-0.1	-1.3	-1.4	-0.8
Forced vital capacity (FVC)	0.6	2.3	9.5	-1.4	1.4	1.3	-3.1	-0.8	-0.4	-0.0
Father’s age at death	0.6	0.8	2.7	0.1	-0.7	-0.2	1.6	1.0	1.2	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.9	0.2	-1.1	0.6	-1.2	-0.3	-0.6	1.4
Headache pain in last month	0.6	1.1	3.2	0.9	0.2	-0.9	-1.8	-0.7	-1.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.3	0.9	-0.6	0.2	0.9	0.5	0.6	-1.5
Age at last live birth	0.6	0.9	2.7	-0.4	-1.5	1.0	-0.5	0.1	-0.3	1.6
Illnesses of siblings: Diabetes	0.6	0.8	3.0	0.7	0.8	1.0	1.7	0.2	-0.4	-0.3
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.9	-0.8	-0.7	0.9	0.3	0.0	-1.4
Average weekly champagne plus white wine intake	0.6	0.8	4.2	-0.1	-0.2	0.7	2.1	0.8	-0.1	0.6
Medication: Bendroflumethiazide	0.6	1.0	4.5	-0.6	-0.8	-2.1	1.0	-0.0	-0.3	0.4
Medication: Lisinopril	0.6	0.8	2.9	0.8	0.7	-0.4	-0.5	-0.8	-0.9	-1.7
Alcohol drinker status: Never	0.6	0.7	2.5	0.3	-1.1	1.6	0.1	0.7	0.2	1.0
Ever smoked	0.6	1.0	3.2	-1.8	-0.6	-0.2	-0.3	0.0	1.4	1.2
Age started oral contraceptive pill	0.6	0.8	2.6	1.6	0.8	-0.8	1.0	-0.0	0.1	-0.7
Pain experienced in last month	0.6	1.1	6.1	-2.5	0.4	0.6	-0.4	-0.2	0.1	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	3.7	-0.8	0.8	0.5	-1.9	0.1	-0.8	-1.4
Rheumatoid Arthritis	0.5	0.7	1.6	0.5	-0.5	0.3	-1.3	-1.1	-0.1	1.1
Schizophrenia (2014)	0.5	1.1	3.3	-0.0	-0.6	1.8	-1.4	1.0	-0.6	0.8
Allergy or Eczema	0.5	1.3	3.5	-0.8	-0.8	1.1	-0.6	-0.0	-1.7	1.9
Respiratory disease	0.5	1.2	5.0	0.2	-0.0	-0.1	2.2	0.7	0.7	1.4
Number of treatments/medications taken	0.5	0.9	3.2	0.5	-1.8	0.3	0.5	1.6	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	-0.9	-0.1	0.6	0.3	1.4	-0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	0.7	-1.4	0.0	1.1	0.5	0.4	0.1
Diabetes (father)	0.5	0.6	2.5	-1.6	1.1	0.3	-0.0	0.4	-0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.0	0.8	-0.3	0.3	-1.7	0.8	-0.2	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.6	0.7	0.3	1.2	-0.0	1.0	1.0
Alcohol usually taken with meals	0.5	0.8	2.9	-0.5	-0.4	1.0	0.4	0.3	1.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.2	0.3	-0.4	1.8	-0.7	1.0	-0.6	-0.3
Allergy	0.5	1.1	6.2	0.4	0.2	-0.5	-0.8	-0.2	0.7	-2.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.3	1.5	-0.6	-0.3	-1.4	-0.5	-0.3	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	0.9	-1.5	-1.1	-0.0	-0.8	0.1	-1.2
Prospective memory result	0.5	0.6	1.7	-0.6	-0.7	0.5	-0.9	-1.3	0.8	-0.5
Birth weight of first child	0.5	1.0	3.0	-1.7	1.4	-0.8	0.9	-0.1	0.3	-0.4
Gout (self-reported)	0.5	0.7	1.5	0.2	-1.2	-0.1	0.4	1.0	1.0	1.2
Forced vital capacity (FVC), Best measure	0.5	1.6	5.3	-0.6	1.7	1.7	-2.3	0.1	0.2	-0.4
Comparative body size at age 10	0.5	1.3	3.2	-1.5	-0.5	-1.1	-0.4	0.4	1.8	-1.3
Shortness of breath walking on level ground	0.5	0.5	1.9	0.5	1.4	0.0	1.0	0.4	0.3	0.6
Number of full sisters	0.5	0.6	1.4	-0.5	-0.5	-0.9	1.2	0.9	-0.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	-0.7	-1.0	0.2	-0.5	0.0	0.9	-1.4
Hypertension (Self-reported)	0.5	1.3	5.5	1.4	0.2	-2.3	-0.7	-0.4	-0.9	-0.2
Ever had bowel cancer screening	0.5	0.5	2.6	-0.5	-1.6	0.1	-0.6	0.3	0.5	0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	2.2	0.8	0.1	1.5	-0.0	0.5	0.6	-0.9
Miserableness	0.5	0.8	2.4	-0.0	-0.1	0.7	-1.5	-0.7	-1.6	0.1
High cholesterol (Self-reported)	0.5	0.8	2.8	-0.2	-0.3	1.7	0.1	1.0	-0.9	-1.0
Average weekly beer plus cider intake	0.5	0.8	2.5	0.2	0.1	0.7	-1.6	-0.7	-1.4	-0.2
Diastolic blood pressure, automated reading	0.5	1.7	4.1	0.1	1.7	-2.0	0.6	-2.0	-0.6	-0.5
Unable to work because of sickness or disability	0.5	0.6	2.9	-0.4	-0.3	1.7	-0.3	0.6	-0.6	-0.5
Myopia	0.5	0.7	2.3	0.1	-0.7	0.7	-0.1	0.7	1.0	1.5
Vascular/heart problems diagnosed by doctor	0.5	1.2	6.1	-1.4	-0.1	2.5	0.1	-0.3	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	-1.4	-0.4	0.2	-1.2	-0.9	-0.2	0.6
Heart disease (siblings)	0.5	0.6	2.3	-0.3	1.5	-0.0	0.3	0.9	-1.0	-0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	0.0	-0.5	1.6	-1.5	0.5	-0.2	1.0
Prostate Cancer	0.4	0.5	1.2	0.1	-0.0	0.8	-0.8	0.1	-1.1	1.1
Bipolar Disorder (2011)	0.4	0.3	2.1	0.3	0.4	-0.1	-1.5	0.0	0.0	0.0
Triglycerides	0.4	0.6	2.2	-0.3	-0.8	1.5	-0.9	0.7	-0.1	-0.3
Smoking Status	0.4	1.0	2.2	-0.8	-1.0	1.5	-1.4	0.3	1.0	-0.2
Hypothyroidism (self reported)	0.4	0.9	1.9	0.7	-1.4	0.3	0.8	0.7	-0.8	-1.4
Neuroticism	0.4	0.9	2.6	0.1	1.1	0.8	-0.7	0.5	-1.0	-1.6
Chronotype (morning person)	0.4	0.9	5.0	-0.3	2.2	0.5	-0.5	0.1	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	0.4	-0.1	-0.8	-1.1	-0.9	-0.6	-0.6
Age when periods started (menarche)	0.4	0.9	3.3	-0.0	0.9	1.2	-0.5	-0.4	0.1	1.8
High blood pressure (mother)	0.4	0.6	2.5	0.3	0.9	0.7	-0.2	-0.2	-0.5	1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-1.0	-0.6	0.4	-0.8	0.7	-0.1	0.7
Mouth/teeth dental problems	0.4	0.6	1.4	-1.2	0.5	-1.0	0.8	-0.6	0.0	0.8
Pain all over the body in last month	0.4	0.4	0.9	-0.3	-1.0	0.7	-0.9	-0.3	-0.6	0.4
Worrier / anxious feelings	0.4	0.7	2.9	0.8	-0.6	0.7	-0.7	-1.7	0.2	0.4
Noisy workplace	0.4	0.4	1.0	0.1	-0.0	0.7	-0.8	1.0	-0.5	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.9	0.6	-1.4	-0.2	0.8	1.2	-0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.1	0.5	0.4	-1.0	1.0	-0.5	-1.1
Diabetes diagnosed by doctor	0.4	0.7	1.5	1.2	-1.2	-0.9	0.7	0.3	0.2	-0.8
Qualifications: nursing, teaching	0.4	0.6	3.0	-0.7	-0.3	-1.7	0.4	-0.2	0.8	-0.3
Medication for cholesterol	0.4	0.5	2.6	-0.3	0.4	-0.6	0.0	-1.6	0.5	0.6
Medication: Gliclazide	0.4	0.4	1.7	0.6	-1.3	-0.2	0.4	-0.6	0.1	-0.5
Number of self-reported non-cancer illnesses	0.4	0.8	2.3	0.8	-1.5	0.2	-0.3	1.4	-0.4	0.7
Commuting to job workplace: Public transport	0.4	0.4	0.8	0.7	-0.7	0.5	0.1	0.9	-0.7	0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-0.1	0.3	-0.7	0.8	0.9	-0.4	1.1
Medication: Paracetamol	0.4	0.5	2.5	-0.1	-0.3	0.3	-1.6	-0.8	-0.6	0.3
Schizophrenia (2018)	0.3	0.5	1.3	-0.1	-0.2	0.9	-1.2	1.1	0.5	0.1
Worry (Nagel 2018)	0.3	0.7	1.7	0.8	-1.0	1.1	-0.0	0.2	-1.3	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.1	-1.1	-0.6	0.8	0.2	0.2	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	-0.3	0.0	-1.1	-0.1	-0.9	-1.3	1.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-1.0	0.4	-0.1	-1.2	0.0	-0.4	0.1
BMI	0.3	2.0	5.5	-0.1	-2.4	-2.2	1.1	-1.4	0.0	-0.4
Systolic blood pressure, automated reading	0.3	0.9	3.3	1.0	1.8	-0.7	-0.1	-1.2	-0.3	-0.5
Vitamin and mineral supplements	0.3	0.4	1.0	0.0	0.6	0.2	0.2	1.0	0.9	0.6
Pack years adult smoking proportion	0.3	0.4	0.8	0.1	0.4	0.9	0.9	0.7	-0.5	-0.5
Impedance of leg (right)	0.3	1.4	5.4	0.7	0.5	2.3	-0.5	0.5	-0.7	1.6
Medication: Levothyroxine sodium	0.3	0.5	1.7	0.0	-0.8	-0.2	0.9	0.1	-1.3	0.3
Waist circumference	0.3	1.0	1.9	1.4	-1.4	-0.4	0.9	-1.0	-0.1	1.2
Had menopause	0.3	0.3	0.7	0.6	-0.5	-0.2	-0.2	-0.9	-0.6	-0.7
Diabetes (self-reported)	0.3	0.5	1.1	1.1	-0.8	-0.2	1.0	0.1	0.2	-0.7
Illnesses of siblings	0.3	0.5	1.6	0.2	-1.3	0.1	-0.5	0.1	1.1	-0.3
Neuroticism score	0.3	0.7	3.1	-0.2	0.0	1.7	-0.9	0.3	-0.8	-0.5
Hip circumference	0.3	1.1	4.6	1.3	-2.1	-0.1	0.6	-0.2	0.7	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.2	0.5	0.1	1.0	-0.3	0.7	-1.1	-0.2
Pulse rate	0.3	0.5	1.2	-0.7	0.9	0.5	0.7	-0.5	-0.2	-1.1
Medication: Lansoprazole	0.3	0.4	0.9	-0.5	0.2	0.8	-0.8	0.4	-1.0	0.3
Lung cancer (father)	0.3	0.4	1.2	1.1	-1.0	0.2	0.3	-0.2	0.6	-0.0
Blood clot in the leg (DVT)	0.3	0.4	1.2	-1.1	-0.0	0.3	0.4	0.5	0.8	-0.3
Medication: Paracetamol	0.3	0.5	2.4	-0.2	-0.0	0.5	-1.5	-0.8	-0.7	0.3
Leg fat percentage (right)	0.3	0.9	2.9	1.7	-0.7	-0.0	-0.1	-1.3	-0.0	1.1
Number of children fathered	0.3	0.3	1.1	0.9	-0.3	-0.3	0.5	0.3	1.1	0.1
Qualifications: College or University degree	0.3	1.0	4.0	-2.0	0.7	-0.3	-1.1	-0.8	-0.7	0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	2.2	0.6	0.1	-0.2	0.7	-0.9	1.5	0.1
Neck or shoulder pain in last month	0.3	0.4	1.6	-0.3	0.9	-0.4	-0.4	0.1	-1.3	-0.5
Pulse rate, automated reading	0.3	0.9	2.1	0.5	-1.0	0.4	1.4	-1.3	-1.1	0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	0.2	0.3	-0.3	-0.4	-1.0	0.9	0.4
Supplements: Vitamin C	0.3	0.4	2.3	0.3	-0.1	-0.0	-0.2	0.2	-0.1	-1.5
Osteoarthritis (self-reported)	0.3	0.4	0.9	-0.1	-0.7	-0.7	-0.4	0.0	-0.9	-1.0
Irritability	0.3	0.5	1.8	-0.6	1.3	0.7	0.5	0.5	-0.2	-0.1
Risk taking	0.3	0.5	1.2	-1.1	-0.5	-0.1	-0.8	0.8	-0.6	-0.3
Supplements: Calcium	0.3	0.3	1.2	0.1	-0.4	0.3	0.3	0.5	0.8	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.3	-1.1	-0.1	0.5	0.0	0.6	0.7	0.1
Pack years of smoking	0.3	0.4	1.3	0.5	0.1	0.5	1.1	0.6	-0.2	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.8	-0.1	-0.1	-0.7	0.4	-0.8	-0.8	1.7
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.2	0.6	1.1	-0.8	0.1	-0.8	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.7	-0.1	-0.1	0.1	-0.8	0.4	-0.0	-0.9
Breast Cancer	0.2	0.5	1.8	-0.4	-0.2	-0.0	-0.3	0.5	1.0	1.3
Waist Hip Ratio (WHR)	0.2	0.7	2.8	1.0	0.2	0.5	1.7	-0.7	0.2	0.6
Systolic Blood Pressure	0.2	0.8	4.3	-0.3	2.1	0.6	-0.0	-0.2	-0.6	0.7
Cardiovascular Disease	0.2	0.8	1.8	1.3	0.0	-0.6	-0.8	-0.4	-1.3	-0.8
Sensitivity / hurt feelings	0.2	0.4	1.3	0.0	0.5	1.1	-0.7	0.2	-0.7	-0.6
Medication: Metformin	0.2	0.3	1.3	0.4	-0.3	-0.4	0.4	-0.2	-1.1	-0.5
Body mass index (BMI)	0.2	0.7	2.0	0.7	-1.1	-1.4	0.4	-1.0	0.1	0.1
Impedance of leg (left)	0.2	1.1	3.7	-0.0	0.3	1.9	-0.7	0.4	-1.1	1.5
Trunk fat mass	0.2	0.7	2.0	0.2	-0.7	-1.4	0.3	-1.1	-0.4	1.1
Hearing difficulty/problems with background noise	0.2	0.4	1.0	0.1	-0.8	-1.0	-0.3	0.5	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.4	1.6	-0.4	0.4	-0.6	0.3	-0.1	-0.6
Qualifications: None of the above	0.2	0.3	1.2	-0.1	0.8	-0.1	0.7	0.2	-1.1	0.2
Arm fat percentage (right)	0.2	0.8	1.7	1.1	-0.8	-1.3	0.5	-1.1	-0.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	-0.4	0.2	-0.3	0.4	-0.1	0.3	0.9
Illnesses of mother	0.2	0.3	0.9	-0.2	-0.0	-0.9	-0.4	-0.4	-0.1	-0.7
Arm fat mass (right)	0.2	0.8	2.6	0.6	-0.8	-1.6	0.6	-1.0	0.2	0.7
Breastfed as a baby	0.2	0.2	0.5	-0.3	0.1	-0.2	-0.7	-0.0	-0.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-1.0	0.2	-0.1	-0.5	0.2	0.4	0.6
Pulse wave reflection index	0.2	0.3	0.7	0.8	-0.1	-0.2	0.7	-0.1	0.3	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	-1.0	-0.6	-0.5	0.2	0.9	0.1	-0.1
Glaucoma (self-reported)	0.2	0.3	1.1	0.2	-0.4	-0.1	0.3	1.1	0.5	-0.3
Medication: Amlodipine	0.2	0.3	0.9	0.4	-1.0	-0.0	-0.5	0.1	0.5	-0.9
Body fat percentage	0.2	0.6	1.1	0.7	-0.8	-0.9	0.2	-1.0	-0.4	1.0
Worry too long after embarrassment	0.2	0.4	1.2	0.4	0.3	1.0	0.4	1.1	0.4	-0.2
Medication: Ibuprofen	0.2	0.2	0.6	-0.4	0.7	-0.1	-0.0	0.5	-0.1	0.7
Medication: Allopurinol	0.2	0.3	0.8	0.1	0.0	-0.9	0.6	-0.6	-0.1	0.5
Whole body fat mass	0.2	0.7	2.0	0.5	-0.6	-1.4	0.2	-1.0	-0.3	0.9
Arm fat percentage (left)	0.2	0.7	1.8	0.6	-0.6	-1.3	0.2	-1.3	-0.4	0.7
Average weekly red wine intake	0.2	0.3	0.6	-0.7	0.0	0.7	0.1	0.5	-0.7	0.4
Arm fat mass (left)	0.2	0.8	3.0	0.4	-0.8	-1.7	0.3	-1.1	0.0	0.6
Guilty feelings	0.2	0.3	1.0	-0.5	0.1	1.0	-0.6	0.3	0.3	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.3	-0.6	-0.4	0.2	0.7	-0.1	-0.6
Medication: Blood pressure	0.2	0.4	0.9	0.9	0.6	-0.6	0.8	0.7	0.1	0.4
Medication: Atorvastatin	0.2	0.3	0.7	0.0	-0.8	0.3	0.5	0.3	0.7	-0.8
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.5	0.7	-0.5	-0.6	0.0	0.3	0.0
Leg fat percentage (left)	0.2	0.8	1.7	1.3	-1.0	-0.3	-0.2	-1.2	-0.0	1.1
Blood Eosinophil Count	0.1	0.8	2.0	-0.3	1.1	0.9	-0.8	-0.1	-0.9	-1.4
Blood Platelet Count	0.1	1.3	2.1	1.4	-1.4	1.4	-0.6	-0.3	0.5	1.4
Blood Red Count	0.1	0.6	1.4	0.0	0.2	1.2	-1.0	-0.9	-0.2	0.9
Heel T-Score	0.1	1.1	3.4	1.1	0.2	-0.9	-0.4	1.8	-0.9	-1.2
Leg fat-free mass (left)	0.1	0.3	1.3	-0.0	-0.5	-1.1	-0.1	-0.6	0.5	0.1
Trunk fat percentage	0.1	0.6	1.2	0.4	-0.7	-1.1	0.4	-0.9	-0.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	1.1	0.2	0.2	-0.5	-0.2	0.6	0.1
Sitting height	0.1	0.7	1.2	-0.9	-1.1	-1.0	-0.0	0.3	0.7	1.1
Leg predicted mass (left)	0.1	0.4	1.6	-0.1	-0.6	-1.3	-0.1	-0.7	0.4	0.2
Weight	0.1	0.7	1.8	0.3	-1.1	-1.4	-0.1	-1.0	0.2	0.9
Impedance of arm (right)	0.1	0.6	2.4	0.2	0.3	1.3	0.0	0.2	-0.3	1.6
Trunk fat-free mass	0.1	0.5	1.3	-0.0	-0.9	-1.1	0.1	-0.7	0.8	0.4
Impedance of arm (left)	0.1	0.5	1.2	-0.3	0.6	0.9	-0.3	-0.2	-0.9	1.1
Trunk predicted mass	0.1	0.5	1.4	-0.0	-0.9	-1.2	0.1	-0.7	0.9	0.4
High blood pressure (siblings)	0.1	0.2	0.5	-0.4	0.7	-0.1	-0.0	-0.7	-0.3	0.3
Arm fat-free mass (right)	0.1	0.4	1.4	-0.5	-0.6	-1.2	-0.2	-0.6	-0.1	0.1
Age at first live birth	0.1	0.2	0.8	-0.6	-0.5	0.9	0.2	-0.1	0.5	0.2
Leg fat mass (right)	0.1	0.5	1.1	0.8	-0.4	-0.9	0.1	-1.0	-0.1	0.8
Arm predicted mass (right)	0.1	0.4	1.7	-0.4	-0.7	-1.3	-0.3	-0.5	-0.2	-0.1
Comparative height size at age 10	0.1	0.8	4.2	-0.6	-0.4	-0.3	-2.0	0.0	-0.7	-0.4
Whole body fat-free mass	0.1	0.4	1.3	-0.2	-0.7	-1.1	-0.1	-0.6	0.5	0.2
Leg fat-free mass (right)	0.1	0.5	2.1	-0.6	-0.5	-1.4	-0.3	-0.6	0.2	-0.0
Whole body water mass	0.1	0.4	1.9	-0.3	-0.6	-1.4	-0.1	-0.7	0.5	0.1
Leg predicted mass (right)	0.1	0.5	2.2	-0.6	-0.4	-1.5	-0.3	-0.7	0.2	0.0
Basal metabolic rate	0.1	0.4	1.5	-0.1	-0.7	-1.2	-0.1	-0.7	0.4	0.4
Arm fat-free mass (left)	0.1	0.4	1.4	-0.0	-0.8	-1.2	0.2	-0.4	0.8	0.2
Impedance of whole body	0.1	0.7	2.6	-0.2	0.7	1.6	-0.5	0.4	-0.7	1.0
Leg fat mass (left)	0.1	0.6	1.1	0.8	-0.6	-1.0	-0.1	-1.1	-0.0	0.9
Arm predicted mass (left)	0.1	0.5	2.0	0.2	-1.0	-1.4	0.3	-0.6	0.6	0.1
Height	0.0	0.2	1.1	-0.2	0.2	0.2	-0.3	0.1	0.0	1.0
Hair Pigment	0.0	0.8	1.7	0.8	-0.1	1.1	0.7	1.3	0.9	1.0
Tanning	0.0	0.5	1.3	-0.4	0.5	-1.1	-1.1	-0.6	0.4	-0.2
Standing height	0.0	0.5	1.4	-1.2	-0.0	-0.5	-0.6	-0.0	0.4	1.2

Hub : Genes

CCDC69

Models

Trait associations