Hub : Genes

CCDC85A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.065 0.026 8.1e-03 0.041 0.02 0.014 NA 0.026 8.7e-06 0.0017 7.0e-03 NA 3.2e-04
2 GTEx Brain Cerebellar Hemisphere 0.275 0.105 8.2e-03 0.234 NA 0.129 NA 0.191 1.1e-06 NA 3.4e-04 NA 1.2e-05
3 GTEx Brain Putamen basal ganglia 0.194 0.097 6.3e-03 -0.011 NA -0.004 NA -0.007 6.9e-01 NA 4.1e-01 NA 5.2e-01
4 GTEx Cells Transformed fibroblasts 0.171 0.048 3.5e-07 0.093 NA 0.056 NA 0.063 1.8e-07 NA 5.1e-05 NA 1.7e-05
5 GTEx Thyroid 0.168 0.046 7.1e-05 0.080 NA 0.047 NA 0.053 9.6e-07 NA 1.7e-04 NA 6.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 2.0 -0.5 1.3 0.3 0.1 1.4
Bipolar Disorder or Schizophrenia 0.3 0.8 1.8 0.2 1.1 -0.5 0.9 1.4
Depressed Affect (Nagel 2018) 2.9 6.2 14.6 -3.8 2.2 -0.7 -0.6 3.3
Depression (Nagel 2018) 5.8 8.8 17.0 -3.5 3.5 0.3 -1.4 4.1
Intelligence (Savage-Jansen 2018) 1.3 4.0 9.6 1.1 0.1 3.1 -3.0 -0.5
Neuroticism (Nagel 2018) 4.8 11.2 21.2 -4.4 3.8 -0.2 -0.9 4.6
Schizophrenia (2018) 0.3 0.6 1.2 0.6 0.3 -0.9 1.1 0.6
Schizophrenia vs Biploar Disorder 1.0 1.3 3.8 2.0 -1.2 0.2 0.5 -1.1
Worry (Nagel 2018) 4.7 9.9 18.0 -3.8 4.0 -0.1 -1.1 4.2
Alzheimer’s Disease (in mother) 4.4 5.2 13.1 2.1 -3.6 0.8 -0.1 -2.8
Alzheimer’s Disease (in father) 0.6 0.6 1.4 0.9 -0.6 0.6 -1.2 -0.2
Alzheimer’s Disease (including proxy) 0.7 1.0 2.5 0.8 -1.6 0.9 -0.0 -0.9
Crohns Disease (2017) 0.5 1.0 2.9 -1.0 -0.6 1.7 -1.0 -0.2
Irritable Bowel Disease (IBD) 0.1 0.3 1.0 0.2 0.1 1.0 0.6 0.3
Ulcerative Colitis (UC) 0.5 1.0 3.5 1.1 0.4 -0.3 1.9 0.4
Major Depression (MDD) 1.7 2.1 4.7 -0.7 1.6 -0.8 1.3 2.2
Reaction Time 9.3 17.8 33.7 -5.8 5.2 0.1 -0.4 5.3
Verbal and Numeric Reasoning (VNR) 3.2 7.7 18.1 1.9 -0.0 4.0 -4.2 -0.9
Breast Cancer 0.1 0.2 0.5 0.7 0.1 -0.2 -0.6 -0.0
Ovarian Cancer 0.8 1.0 2.5 1.6 -1.3 -0.5 -0.2 -0.7
Prostate Cancer 1.3 1.8 4.3 0.0 0.3 2.1 -2.0 0.5
Age at First Birth 2.1 3.1 6.1 -2.0 2.5 0.2 -0.1 2.2
Bipolar Disorder (2011) 0.6 0.6 2.1 -0.3 1.4 0.1 -0.4 0.9
Body Mass Index (BMI) (2010) 1.2 1.7 4.2 0.8 -2.0 -0.2 0.1 -1.9
Coronary Artery Disease (CAD) 0.5 0.6 1.3 0.5 -1.1 0.2 0.0 -1.1
Crohns Disease (2012) 0.7 1.1 1.7 0.8 -1.3 0.8 -1.1 -1.0
Mean Putamen Volume 0.8 0.9 1.7 1.1 -0.8 -1.3 0.9 -0.6
Fasting Glucose 0.3 0.4 1.4 0.3 0.4 -1.2 0.5 0.4
HbA1C 0.6 0.7 2.0 0.4 0.5 -1.4 1.0 0.1
HDL Cholesterol 0.1 0.2 0.7 0.9 -0.0 -0.1 0.6 -0.1
LDL Cholesterol 0.6 0.9 2.4 0.8 -0.4 -1.6 0.8 -0.7
Lupus 0.5 0.7 3.2 -1.8 0.2 -0.2 0.6 -0.1
Neuroticism (2016) 2.6 3.8 5.4 -2.3 1.7 -1.9 1.3 2.3
Primary Biliary Cirrhosis 1.1 1.5 2.7 0.2 1.6 0.5 -1.4 1.6
Rheumatoid Arthritis 1.0 1.3 2.7 -1.6 0.5 -1.6 -0.4 0.9
Schizophrenia (2014) 0.4 1.0 2.3 0.8 0.4 -1.1 1.5 0.6
Triglycerides 0.8 1.3 2.1 0.6 -1.4 -1.3 0.4 -1.4
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.9 -0.4 -1.2 -0.4 0.1 -1.4
Ulcerative Colitis 1.1 1.7 2.8 -0.2 1.6 -0.7 1.7 1.5
Blood Eosinophil Count 0.8 5.8 11.2 1.3 -3.4 -1.6 1.6 -3.3
Blood Platelet Count 0.1 1.1 2.0 1.4 -1.4 -0.6 0.3 -1.2
Blood Red Count 0.1 1.0 1.7 0.8 -0.7 1.1 -1.3 -0.9
Blood White Count 0.3 2.5 4.9 2.0 -1.7 -0.4 -0.7 -2.2
Heel T-Score 0.1 0.9 1.6 0.7 -0.9 1.0 -1.3 -0.9
BMI 0.8 4.8 11.0 -0.9 -2.2 -3.3 1.6 -2.2
Height 0.2 4.6 17.6 4.2 -0.5 -0.6 1.2 1.8
Waist Hip Ratio (WHR) 2.1 9.3 23.9 1.6 -4.9 -1.0 0.6 -4.3
Systolic Blood Pressure 0.6 2.8 7.5 -2.7 0.2 -2.1 1.4 0.2
Smoking Status 0.8 1.9 4.0 1.6 -1.8 0.3 0.1 -2.0
Allergy or Eczema 0.1 0.3 0.7 0.3 -0.4 0.4 0.8 -0.5
Cardiovascular Disease 0.7 2.2 3.4 -1.5 -1.0 -1.8 1.8 -1.1
Hypothyroidism (self reported) 0.3 0.6 1.3 -1.0 -1.1 -0.5 0.2 -0.6
Respiratory disease 0.4 0.8 1.6 0.6 -1.3 -0.2 0.9 -1.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.7 -1.3 -0.8 -1.2 0.3 -1.0
Lung FEV1/FVC ratio 0.1 0.4 0.7 -0.8 -0.4 -0.3 -0.8 -0.8
Lung FVC 0.4 2.0 3.8 1.6 0.7 1.6 -2.0 0.9
Neuroticism 4.9 11.8 21.9 -4.5 3.8 0.6 -1.3 4.7
Chronotype (morning person) 0.2 0.4 1.2 0.2 -0.3 0.2 -1.1 -0.7
Hair Pigment 0.1 1.5 3.4 -0.2 1.2 1.9 -1.1 1.3
Tanning 0.2 2.1 4.0 1.7 -1.4 0.9 -1.0 -2.0
Hand grip strength (left) 1.6 4.2 10.3 0.2 0.4 -3.2 3.2 0.4
Number of treatments/medications taken 2.0 3.6 6.6 -1.5 -1.7 -2.1 2.6 -1.3
Average weekly spirits intake 0.4 0.5 1.3 -1.1 0.5 -0.3 -0.5 0.8
Sensitivity / hurt feelings 3.0 5.1 9.7 -3.1 2.5 -0.8 -0.2 3.0
Frequency of depressed mood in last 2 weeks 7.7 10.7 20.1 -4.5 3.6 0.6 -2.0 4.0
Hearing difficulty/problems: Yes 0.0 0.0 0.1 -0.0 -0.0 0.2 -0.3 -0.3
Relative age of first facial hair 0.6 1.1 2.0 -1.4 1.4 0.6 -0.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.9 0.4 -0.9 -0.3 0.7 -1.0
Ever used hormone-replacement therapy (HRT) 1.4 1.7 3.7 -0.1 1.1 -1.7 1.9 1.0
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.0 -1.2 -0.1 -1.0 -0.9
Systolic blood pressure, automated reading 0.3 0.8 2.0 -1.4 -0.5 -1.0 0.6 -0.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.3 -1.1 1.1 -0.3 0.7 0.9
Angina 1.1 1.4 2.6 -1.6 0.5 -1.4 1.4 0.5
Medication for hormone replacement therapy 1.7 1.9 4.1 1.9 -0.5 -1.1 2.0 -0.8
Vitamin and mineral supplements 0.7 1.0 2.3 0.3 -1.5 -0.4 -0.4 -1.4
Supplements: Zinc 0.8 0.9 2.3 -0.3 -0.0 1.5 -1.4 0.1
Medication: Co-codamol 0.9 1.1 1.7 -1.3 1.2 -0.0 -1.1 1.1
Medication: Metformin 0.2 0.3 1.5 -1.2 0.1 -0.2 0.4 -0.1
Diabetes (father) 1.4 1.7 3.0 1.3 -1.7 -1.0 0.2 -1.7
Diabetes (mother) 1.1 1.4 4.0 -2.0 0.1 -1.7 0.3 0.2
Severe depression (siblings) 0.2 0.2 0.3 -0.2 0.5 -0.6 0.0 0.6
Pack years adult smoking proportion 0.3 0.4 0.7 0.8 -0.8 0.2 -0.4 -0.6
Impedance of leg (right) 0.4 2.0 5.4 2.3 -1.3 1.0 -0.3 -1.3
Leg fat-free mass (left) 0.4 2.0 7.4 -1.0 -0.1 -2.7 1.0 0.7
Trunk fat percentage 1.8 7.4 14.4 1.1 -3.3 -3.8 1.4 -2.9
Hand grip strength (right) 0.6 1.6 4.7 -0.2 -0.3 -1.7 2.2 -0.4
Townsend deprivation index at recruitment 0.5 0.6 2.3 -0.9 0.2 0.2 -1.5 0.1
Current tobacco smoking 1.4 2.3 5.6 0.8 -2.1 0.4 0.6 -2.4
Average weekly fortified wine intake 0.3 0.4 1.5 -0.1 0.3 0.3 1.2 0.3
Maternal smoking around birth 0.5 0.8 1.5 1.2 -0.9 -0.9 0.1 -0.9
Fed-up feelings 3.6 6.6 13.4 -3.3 2.9 0.6 -0.3 3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.3 7.2 -2.7 1.9 1.2 -2.3 2.0
Relative age voice broke 1.2 1.9 3.3 -0.9 1.8 0.6 -1.8 1.3
Taking other prescription medications 1.3 2.0 3.1 -1.8 -1.2 -1.5 1.6 -0.9
Age when periods started (menarche) 1.3 3.2 4.4 -1.4 2.1 -2.1 1.1 2.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.3 -0.2 -0.1 -1.2 0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.5 0.7 -0.4 1.6 -0.4 -0.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.2 -0.7 0.2 0.0 -0.7
Qualifications: CSEs or equivalent 1.6 2.1 3.9 -2.0 2.0 -0.6 -0.1 1.5
Serious illness, injury or assault to yourself 0.5 0.6 2.1 0.3 -0.5 -1.5 0.9 0.0
High blood pressure 0.8 2.1 3.6 -1.4 -0.9 -1.9 1.8 -1.0
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 -0.3 0.5 0.6 0.7 0.0
Multivitamins +/- minerals 0.4 0.5 1.1 0.4 1.1 -0.0 0.6 1.1
Stomach or abdominal pain in last month 1.1 1.4 2.4 -1.5 1.0 -1.0 0.4 1.5
Supplements: Glucosamine 1.2 1.6 2.5 1.6 -1.2 -0.6 1.3 -1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.8 -0.3 0.2 -0.5 0.9 0.7
Medication: Atenolol 1.7 2.1 5.6 -2.4 1.0 -0.1 1.7 0.9
Medication: Levothyroxine sodium 0.4 0.7 1.8 -0.6 -1.4 -0.7 0.7 -0.3
Sitting height 0.2 1.1 4.9 2.2 -0.7 -0.2 -0.0 0.2
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 -0.0 1.1 1.0 -0.7 0.7
High blood pressure (mother) 0.9 1.3 2.2 -0.3 1.2 -1.4 0.8 1.5
Body mass index (BMI) 0.8 3.3 9.5 -1.0 -1.6 -3.1 1.0 -1.5
Impedance of leg (left) 0.4 1.9 5.3 2.3 -1.4 0.6 -0.0 -1.5
Leg predicted mass (left) 0.4 2.1 7.9 -1.1 -0.1 -2.8 1.0 0.7
Trunk fat mass 1.5 6.4 13.6 1.0 -3.1 -3.7 1.3 -2.5
Waist circumference 1.8 6.5 12.2 0.6 -3.5 -3.0 0.6 -3.2
Number of incorrect matches in round 0.9 1.4 2.1 -1.3 1.3 -0.6 1.2 1.5
Past tobacco smoking 0.5 0.9 2.6 -1.1 0.4 -0.8 1.6 0.3
Alcohol usually taken with meals 1.6 2.6 8.1 1.3 -0.1 2.8 -1.7 -0.6
Nervous feelings 4.5 8.3 15.1 -3.9 3.6 0.5 -0.2 3.6
Frequency of tenseness / restlessness in last 2 weeks 3.0 4.7 8.5 -2.5 2.8 0.6 -0.3 2.9
Hearing difficulty/problems with background noise 0.7 1.1 1.9 -1.1 0.9 -0.4 1.2 1.4
Hair/balding pattern: Pattern 2 1.4 1.7 3.5 -1.0 1.9 0.6 -0.8 1.8
Had menopause 0.4 0.5 1.3 0.2 -1.1 -0.4 0.3 -1.0
Had other major operations 0.4 0.5 1.0 0.5 -1.0 -0.5 0.2 -1.0
Forced vital capacity (FVC) 0.3 1.1 2.1 1.1 0.5 0.4 -1.5 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.0 0.7 -0.1 1.4 -0.8 -0.3
Ever unenthusiastic/disinterested for a whole week 3.6 4.4 10.6 -3.3 2.0 -1.3 0.7 2.3
Qualifications: None of the above 1.7 3.5 6.0 -0.4 -2.4 -2.1 2.2 -1.5
Financial difficulties in last 2 years 1.5 2.1 6.1 -1.0 1.1 0.6 -2.5 1.2
Mouth/teeth dental problems 0.3 0.4 1.6 0.4 0.2 -0.7 1.2 0.2
Heart attack 0.7 0.9 1.9 -1.4 0.2 -1.0 1.1 0.5
Allergy 0.1 0.3 0.8 0.4 0.2 -0.2 -0.9 0.6
Pain all over the body in last month 0.5 0.5 1.0 -0.7 -0.9 -0.2 1.0 -0.5
Diabetes (self-reported) 0.4 0.6 1.0 -0.8 -0.6 -1.0 0.8 -0.7
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 7.6 0.0 0.6 2.8 -1.9 0.4
Medication: Ramipril 1.4 1.8 4.7 0.1 -0.9 -1.6 2.2 -0.9
Medication: Simvastatin 0.4 0.6 1.8 0.0 -0.3 -1.0 1.4 -0.3
Fluid intelligence score 4.0 8.3 21.0 1.8 -0.0 4.1 -4.6 -0.7
Illnesses of siblings 0.9 1.2 4.8 2.2 -0.2 0.9 0.7 0.1
Neuroticism score 4.8 9.9 18.5 -4.3 3.7 -0.3 -0.6 4.2
Weight 0.6 3.2 10.0 0.2 -1.9 -3.2 1.1 -1.1
Impedance of arm (right) 0.3 1.3 5.2 2.3 -0.6 -0.5 0.6 -0.5
Arm fat percentage (right) 1.5 5.9 14.6 0.6 -2.6 -3.8 1.4 -2.5
Trunk fat-free mass 0.1 0.6 1.8 -0.2 0.0 -1.4 0.5 0.9
Hip circumference 0.3 1.4 5.6 0.1 -0.9 -2.4 0.6 -0.7
Time employed in main current job 1.9 2.2 4.7 2.1 -0.0 -1.3 2.2 -0.4
Alcohol intake versus 10 years previously 0.4 0.6 1.6 -0.3 1.2 -0.3 -0.0 1.1
Father’s age at death 1.0 1.4 2.4 0.4 1.4 0.6 1.3 1.5
Worrier / anxious feelings 4.0 7.5 13.3 -3.3 3.2 -1.0 -1.4 3.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.4 -1.2 -0.0 0.5 -1.0 0.6
Falls in the last year 0.1 0.1 0.2 -0.4 0.0 -0.0 -0.5 0.3
Hair/balding pattern: Pattern 3 0.3 0.5 0.7 0.7 -0.4 0.9 -0.8 -0.7
Number of live births 0.2 0.3 0.7 -0.8 0.5 0.6 -0.4 0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.2 0.6 0.3 -0.1 -1.5 0.9
Pulse rate 1.4 2.4 4.2 2.1 -1.1 -1.5 1.6 -1.3
Happiness 1.7 2.1 4.1 -1.8 1.7 -0.6 0.1 2.0
Noisy workplace 1.3 1.6 4.1 -2.0 0.7 -1.4 0.0 1.2
Qualifications: A levels/AS levels or equivalent 2.3 5.1 13.7 0.9 1.0 3.7 -3.1 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.9 0.8 1.0 0.8 -1.4 1.0
Mouth/teeth dental problems: Dentures 1.6 2.6 7.0 0.1 -2.6 -0.4 0.4 -2.4
Asthma 0.5 1.0 1.4 1.0 -1.1 -0.6 1.0 -1.2
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 3.1 1.6 -1.6 -0.6 -1.4 -1.8
Medication: Cholesterol lowering 1.0 1.6 4.9 -0.7 -0.3 -1.6 2.2 -0.4
Depression (self-reported) 0.5 0.7 1.6 -0.3 -0.3 -1.2 1.3 -0.1
Medication: Lansoprazole 0.9 1.1 3.4 0.1 -1.8 -0.3 -0.5 -1.3
Prospective memory result 3.3 4.0 13.2 -0.5 -0.0 -2.6 3.6 -0.2
Lung cancer (father) 0.2 0.2 0.7 -0.8 0.1 -0.5 0.0 -0.1
Illnesses of mother 0.1 0.1 0.5 0.3 0.1 0.0 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.5 1.1 0.3 0.5 -0.2 -0.9 1.1
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 1.2 -0.7 0.4 0.3 -0.7
Impedance of arm (left) 0.3 1.5 6.2 2.5 -0.8 -0.1 0.5 -0.6
Arm fat mass (right) 1.1 4.4 12.2 0.1 -2.2 -3.5 1.1 -1.9
Trunk predicted mass 0.1 0.6 1.8 -0.2 0.0 -1.3 0.4 0.9
Standing height 0.2 1.6 6.2 2.5 -0.3 -0.7 0.5 1.1
Length of working week for main job 0.6 0.6 2.4 -1.5 0.4 -0.1 -0.6 0.4
Exposure to tobacco smoke at home 1.8 2.0 5.3 -0.5 -0.4 -2.3 2.1 -0.3
Breastfed as a baby 0.3 0.4 0.8 0.4 0.2 0.9 -0.9 0.2
Tense / ‘highly strung’ 1.5 2.5 4.1 -2.0 2.0 -0.0 -1.2 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 5.8 -2.4 2.2 -0.9 0.7 2.1
Hair/balding pattern: Pattern 4 0.2 0.6 1.7 -0.5 -0.7 -0.7 1.3 -0.1
Birth weight of first child 0.4 0.7 2.5 1.6 -0.2 -0.2 -1.0 -0.3
Peak expiratory flow (PEF) 0.3 0.7 1.2 0.8 0.8 0.0 -1.1 1.1
Pulse wave reflection index 0.1 0.2 0.5 -0.7 -0.4 0.5 0.2 -0.2
Ever highly irritable/argumentative for 2 days 2.2 2.7 6.6 -2.6 1.7 0.8 -1.0 1.6
Loud music exposure frequency 0.2 0.2 0.6 -0.8 0.1 -0.5 0.5 0.3
Qualifications: O levels/GCSEs or equivalent 2.4 3.8 7.9 -0.0 1.8 2.8 -2.4 1.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.0 0.7 1.0 1.0 -0.6 0.8
Blood clot in the leg (DVT) 1.4 1.8 5.3 0.6 -0.9 -2.3 1.4 -0.8
Medication: Paracetamol 0.5 0.8 1.4 0.8 -1.2 -0.5 0.6 -1.1
Headache pain in last month 0.9 1.6 3.1 -1.3 1.6 -0.1 -0.6 1.8
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.3 1.3 0.8 1.8 -1.7 0.9
Glaucoma (self-reported) 0.5 0.6 1.5 -0.5 0.9 -0.5 0.6 1.2
Gout (self-reported) 0.4 0.5 1.0 1.0 -0.6 -0.3 -0.1 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.7 -0.7 -1.6 -0.7 0.2 -0.7
Medication: Amlodipine 0.2 0.3 0.5 0.5 -0.6 -0.7 0.2 -0.7
Medication: Ventolin 100micrograms inhaler 0.8 1.1 3.3 -0.7 -0.5 1.0 -1.8 -0.4
Birth weight 1.2 2.6 6.9 -0.5 2.2 -0.2 -0.9 2.6
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.2 0.3 -0.4 0.2 0.4
High blood pressure (siblings) 0.3 0.5 1.1 -1.0 -0.1 0.0 -1.1 -0.4
Forced vital capacity (FVC), Best measure 0.3 0.9 2.8 0.5 0.9 0.2 -0.8 1.7
Body fat percentage 1.9 7.6 14.7 0.9 -3.3 -3.8 1.5 -3.0
Leg fat percentage (right) 1.7 6.3 10.4 0.5 -3.2 -3.2 1.3 -3.0
Arm fat-free mass (right) 0.1 0.8 3.0 -0.4 -0.6 -1.7 0.5 0.1
Exposure to tobacco smoke outside home 0.9 1.2 2.6 -1.6 1.1 0.5 -0.6 1.2
Comparative body size at age 10 0.3 0.8 1.8 -1.4 -0.9 -0.4 -0.6 -0.9
Number of full brothers 0.1 0.1 0.3 0.2 0.6 -0.5 0.2 -0.0
Worry too long after embarrassment 2.8 4.6 7.7 -2.8 2.5 0.2 -1.3 2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.1 -1.2 1.2 -1.3 2.0 1.5
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 -0.7 -0.9 0.2 -0.1 -0.7
Number of children fathered 1.6 1.8 2.7 1.3 -1.5 1.5 -0.4 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.9 -0.3 0.6 -1.3 2.0 0.7
Age at first live birth 2.2 3.8 9.2 0.2 2.0 3.0 -1.8 1.7
Pulse wave peak to peak time 0.5 0.6 1.4 -1.2 0.8 -0.5 -0.2 0.8
Health satisfaction 0.4 0.5 1.0 -0.9 0.3 0.5 -1.0 0.5
Shortness of breath walking on level ground 0.7 0.9 2.2 -0.9 0.4 -0.9 1.5 0.6
Qualifications: College or University degree 0.7 2.2 5.6 2.1 0.4 2.4 -0.7 -0.7
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.6 -0.3 -0.5 0.1 -0.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.8 0.9 -1.1 0.2 -0.7 -1.3
Emphysema/chronic bronchitis 0.4 0.5 1.6 -0.0 -1.3 0.1 -0.4 -0.8
Medication for pain relief, constipation, heartburn 1.3 2.2 4.1 -0.5 2.0 1.2 -1.4 1.7
Neck or shoulder pain in last month 1.2 1.7 3.3 -1.8 1.4 -1.3 0.1 1.3
Medication: Blood pressure 1.0 1.8 4.0 -2.0 -0.6 -1.6 1.2 -0.7
Angina (self-reported) 1.0 1.4 2.7 -1.6 0.7 -1.2 1.3 0.7
Migraine (self-reported) 0.6 0.7 1.7 1.3 -0.5 -1.2 0.2 0.0
Medication: Ibuprofen 1.7 2.0 3.9 1.0 -2.0 -1.1 -0.3 -2.0
Medication: Allopurinol 0.2 0.2 0.7 -0.5 0.2 -0.4 -0.8 0.1
Medication: Omeprazole 0.9 1.1 2.1 -0.7 -1.0 -1.5 1.4 -0.4
Medication: Seretide 50 evohaler 0.5 0.5 2.3 1.5 -0.4 -0.2 0.1 -0.4
Mean time to correctly identify matches 4.9 9.4 19.2 -4.4 3.7 0.5 -0.6 3.7
Heart disease (mother) 1.2 1.5 3.8 -1.6 0.0 -1.9 1.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.0 0.3 -0.5 0.4 0.1
Whole body fat mass 1.4 6.0 13.8 0.5 -2.9 -3.7 1.5 -2.4
Leg fat mass (right) 1.4 5.6 13.2 0.3 -2.6 -3.6 1.6 -2.3
Arm predicted mass (right) 0.2 1.0 3.7 -0.4 -0.8 -1.9 0.6 0.1
Pulse rate, automated reading 2.5 8.0 12.5 2.6 -2.4 -3.5 2.9 -2.6
Alcohol intake frequency. 0.2 0.5 1.3 -0.9 -0.0 0.6 -1.1 0.1
Comparative height size at age 10 0.1 0.3 0.7 0.2 -0.7 -0.4 -0.8 0.4
Number of full sisters 1.9 2.4 9.0 -1.0 -0.2 -3.0 1.3 -0.2
Suffer from ‘nerves’ 1.2 1.8 4.1 -2.0 1.4 0.0 -0.6 1.6
Overall health rating 0.6 1.4 3.3 -1.7 -0.9 -1.8 0.0 -0.1
Chest pain or discomfort 0.2 0.2 1.1 -0.1 0.1 -0.1 1.1 0.3
Had major operations 2.5 3.0 6.8 0.9 -1.6 2.6 -1.7 -1.4
Age at last live birth 1.4 2.0 5.3 -0.8 1.1 2.3 -1.3 1.2
Family relationship satisfaction 0.7 0.8 2.0 -0.5 1.0 0.8 0.6 1.4
Leg pain on walking 0.7 0.8 2.3 -1.0 -0.8 -0.3 -1.5 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.2 -0.6 1.5 -0.2 -0.3 1.3
Commuting to job workplace: Car/motor vehicle 1.6 1.8 4.2 -0.7 0.3 1.9 -2.0 0.6
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.7 1.3 -1.1 -0.3 1.7 -1.4
Medication: Aspirin 1.8 2.4 4.3 0.3 -2.0 -0.8 2.1 -1.8
Supplements: Vitamin C 1.6 1.9 3.5 -1.7 1.6 0.8 -0.0 1.9
Knee pain experienced in last month 0.1 0.1 0.4 0.3 -0.2 -0.2 -0.7 -0.4
Hypertension (Self-reported) 0.8 2.1 3.9 -1.3 -1.0 -2.0 1.7 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.9 4.6 9.8 -0.2 -2.5 -3.1 1.8 -1.9
Illnesses of father: Heart disease 0.1 0.2 0.6 -0.8 -0.0 0.1 -0.5 -0.1
Illnesses of siblings: Diabetes 3.8 4.6 10.8 -1.9 1.6 -3.3 2.2 1.2
Smoking status: Previous 0.4 0.6 1.5 1.1 0.0 0.3 -1.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 0.9 -0.6 0.3 -1.0 0.7 0.9
Whole body fat-free mass 0.2 1.2 4.2 -0.7 -0.0 -2.0 0.7 0.8
Leg fat-free mass (right) 0.4 2.3 8.4 -1.1 -0.0 -2.9 1.2 0.8
Arm fat percentage (left) 1.5 5.8 12.7 0.6 -2.7 -3.6 1.4 -2.5
Average weekly red wine intake 0.7 1.0 2.0 1.1 -0.8 1.4 -0.3 -1.1
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.1 0.3 -0.7 -1.1 1.4 -0.0
Mood swings 2.3 4.2 12.8 -3.6 1.6 0.1 -1.3 2.0
Loneliness, isolation 2.0 2.7 6.1 -1.8 1.7 -1.0 0.5 2.5
Long-standing illness, disability or infirmity 0.9 1.4 2.0 -1.4 -1.2 -1.1 1.4 -0.6
Ever had bowel cancer screening 0.3 0.4 1.1 0.2 -0.2 0.8 -1.0 0.2
Diabetes diagnosed by doctor 0.5 0.8 1.4 -1.0 -1.1 -0.6 0.1 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.3 1.1 -0.7 1.1 0.7 -0.7
Friendships satisfaction 0.8 1.0 1.9 -0.4 1.4 1.0 -0.8 1.1
Qualifications: nursing, teaching 2.1 3.2 6.9 0.9 1.5 2.5 -2.6 0.5
Commuting to job workplace: Walk 0.3 0.3 1.0 -0.6 0.1 -1.0 -0.3 0.2
Eye problems/disorders: Cataract 0.2 0.2 0.6 -0.2 0.5 0.4 0.8 0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.8 0.2 0.5 -0.4 -1.3 0.5
Medication for cholesterol 2.0 3.0 6.9 -1.5 1.0 1.9 -2.6 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.5 4.2 6.9 1.5 -2.6 -1.9 2.1 -1.9
Back pain experienced in last month 0.8 1.1 3.2 0.1 -1.8 0.6 -0.8 -1.2
Mineral and other dietary supplements 0.1 0.1 0.4 -0.3 0.3 0.3 -0.6 0.1
Breast cancer (self-reported) 1.1 1.3 2.2 0.7 -1.5 -0.7 1.2 -1.3
Asthma (self-reported) 0.3 0.5 0.9 0.7 -0.7 -0.5 0.9 -0.8
Osteoporosis (self-reported) 1.9 2.4 3.3 -1.5 1.7 -1.0 1.8 1.5
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.4 -0.3 -0.2 0.0 -0.3
Medication: Aspirin 1.6 2.1 4.9 -0.4 -1.7 -0.9 2.2 -1.4
Medication: Gliclazide 0.2 0.2 0.7 -0.9 -0.3 -0.3 0.2 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.0 0.6 0.0 0.6 0.6
Smoking status: Current 1.5 2.3 6.0 0.8 -2.1 0.2 0.8 -2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 2.8 -0.7 1.4 1.1 -1.4 1.7
Whole body water mass 0.2 1.1 3.9 -0.7 0.1 -2.0 0.6 1.0
Leg predicted mass (right) 0.4 2.3 8.2 -1.1 0.0 -2.9 1.2 0.8
Arm fat mass (left) 1.2 5.1 12.5 0.6 -2.6 -3.5 1.1 -2.2
Number of self-reported non-cancer illnesses 1.6 2.7 5.4 -1.8 -0.6 -2.1 2.3 -0.4
Average weekly champagne plus white wine intake 2.4 3.3 8.9 3.0 -1.6 -0.7 1.4 -1.6
Miserableness 2.3 3.9 5.3 -2.3 1.8 0.9 -2.3 2.2
Guilty feelings 0.1 0.2 0.4 0.5 0.4 -0.6 0.2 0.4
Wears glasses or contact lenses 2.0 2.3 5.9 1.1 -2.4 -0.3 -0.1 -2.0
Ever taken oral contraceptive pill 0.3 0.3 0.8 -0.1 0.5 0.9 -0.3 0.6
Hearing aid user 0.2 0.3 1.0 1.0 0.1 0.5 -0.2 0.2
Mother’s age at death 0.3 0.4 1.1 1.1 0.1 0.4 0.9 0.0
Financial situation satisfaction 2.3 2.9 9.2 -3.0 1.4 -0.1 -0.4 1.8
Tinnitus: Yes, now most or all of the time 3.2 3.7 7.8 1.0 -1.5 -2.8 2.5 -1.1
Commuting to job workplace: Public transport 2.2 2.6 4.4 2.1 -2.0 -0.5 0.6 -2.0
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -0.9 0.6 -0.2 0.3 1.0
Medication: Blood pressure 1.3 2.6 6.9 1.0 -0.8 -1.9 2.6 -0.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 -1.1 -0.8 -0.3 -0.6 -0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.1 0.1 0.0 -0.7 1.5 0.4
High cholesterol (Self-reported) 1.0 1.7 6.5 0.1 -0.9 -0.7 2.5 -0.8
Medication: Bendroflumethiazide 1.4 2.1 6.8 0.1 -0.4 -1.9 2.6 -0.1
Medication: Paracetamol 0.8 1.2 2.9 0.5 -1.7 -0.3 0.8 -1.5
Medication: Lisinopril 1.3 1.6 3.3 -1.6 -0.5 -1.8 1.3 -0.4
Medication: Atorvastatin 0.3 0.4 1.0 -1.0 -0.7 0.3 0.1 -0.5
Illnesses of father: High blood pressure 1.1 1.4 3.3 0.9 -0.4 -1.8 1.6 -0.3
Alcohol drinker status: Never 2.7 3.2 4.0 1.6 -1.6 1.7 -2.0 -2.0
Ever smoked 0.5 0.8 2.0 0.4 0.2 1.4 -1.2 0.6
Basal metabolic rate 0.2 1.3 5.5 -0.5 -0.5 -2.3 0.7 0.3
Leg fat percentage (left) 1.9 6.7 11.7 0.5 -3.2 -3.4 1.5 -3.0
Arm fat-free mass (left) 0.2 1.3 5.3 -0.4 -0.6 -2.3 0.7 0.2
Number of operations (self-reported) 1.0 1.5 3.7 0.5 -1.9 0.4 -0.5 -1.7
Average weekly beer plus cider intake 0.7 1.1 1.5 -0.9 -1.2 -1.2 0.6 -1.1
Irritability 4.9 8.2 13.0 -3.2 3.6 1.8 -1.6 3.5
Risk taking 2.2 3.2 6.7 1.5 -2.6 -0.4 -0.7 -2.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.2 -0.1 0.7 1.5 -0.3 0.5
Fractured/broken bones in last 5 years 0.5 0.7 1.3 1.1 -0.9 0.5 -0.6 -0.8
Age started oral contraceptive pill 0.7 0.9 2.0 0.0 -0.8 -1.4 1.0 -1.0
Diastolic blood pressure, automated reading 0.4 1.2 2.9 -0.2 -1.7 -1.3 0.3 -1.1
Ever depressed for a whole week 1.6 1.9 3.0 -1.7 1.4 -1.4 0.9 1.4
Unable to work because of sickness or disability 1.4 1.8 5.1 -0.7 -0.6 -2.3 1.7 -0.3
Commuting to job workplace: Cycle 0.4 0.5 1.8 0.4 0.2 1.3 -0.5 0.4
Myopia 0.7 1.1 2.2 1.1 -0.0 1.5 -1.4 0.3
Vascular/heart problems diagnosed by doctor 0.8 2.1 4.3 2.1 0.4 1.6 -1.8 0.5
Cholesterol lowering medication 1.6 2.3 4.5 1.6 -2.1 -0.6 0.2 -2.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 3.4 0.1 -1.8 -1.2 0.9 -1.3
Pain experienced in last month 0.8 1.3 4.3 2.1 -0.7 0.5 0.7 -1.1
Supplements: Calcium 2.3 2.5 4.4 -1.4 1.5 2.1 -0.6 1.9
Basal cell carcinoma (self-reported) 2.1 2.5 5.2 2.3 -1.7 0.8 -0.6 -1.9
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.5 -1.9 0.7 -0.8 1.1 1.0
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 5.3 1.0 -1.1 -2.3 1.6 -1.1
Heart disease (siblings) 0.5 0.7 2.5 -1.6 0.1 -0.8 0.2 -0.1
Alcohol drinker status: Previous 0.1 0.1 0.6 -0.2 -0.1 -0.2 0.8 0.2
Pack years of smoking 0.3 0.5 0.9 0.9 -0.9 0.2 -0.7 -0.5
Impedance of whole body 0.3 1.6 6.4 2.5 -1.0 0.3 0.0 -0.9
Leg fat mass (left) 1.5 5.9 14.6 0.3 -2.6 -3.8 1.7 -2.3
Arm predicted mass (left) 0.1 0.7 3.0 -0.3 -0.6 -1.7 0.2 0.1