Hub : Genes

CCDC85A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.065	0.026	8.1e-03	0.041	0.02	0.014	NA	0.026	8.7e-06	0.0017	7.0e-03	NA	3.2e-04
2	GTEx	Brain Cerebellar Hemisphere	0.275	0.105	8.2e-03	0.234	NA	0.129	NA	0.191	1.1e-06	NA	3.4e-04	NA	1.2e-05
3	GTEx	Brain Putamen basal ganglia	0.194	0.097	6.3e-03	-0.011	NA	-0.004	NA	-0.007	6.9e-01	NA	4.1e-01	NA	5.2e-01
4	GTEx	Cells Transformed fibroblasts	0.171	0.048	3.5e-07	0.093	NA	0.056	NA	0.063	1.8e-07	NA	5.1e-05	NA	1.7e-05
5	GTEx	Thyroid	0.168	0.046	7.1e-05	0.080	NA	0.047	NA	0.053	9.6e-07	NA	1.7e-04	NA	6.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	2.0	-0.5	1.3	0.3	0.1	1.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	0.2	1.1	-0.5	0.9	1.4
Depressed Affect (Nagel 2018)	2.9	6.2	14.6	-3.8	2.2	-0.7	-0.6	3.3
Depression (Nagel 2018)	5.8	8.8	17.0	-3.5	3.5	0.3	-1.4	4.1
Intelligence (Savage-Jansen 2018)	1.3	4.0	9.6	1.1	0.1	3.1	-3.0	-0.5
Neuroticism (Nagel 2018)	4.8	11.2	21.2	-4.4	3.8	-0.2	-0.9	4.6
Schizophrenia (2018)	0.3	0.6	1.2	0.6	0.3	-0.9	1.1	0.6
Schizophrenia vs Biploar Disorder	1.0	1.3	3.8	2.0	-1.2	0.2	0.5	-1.1
Worry (Nagel 2018)	4.7	9.9	18.0	-3.8	4.0	-0.1	-1.1	4.2
Alzheimer’s Disease (in mother)	4.4	5.2	13.1	2.1	-3.6	0.8	-0.1	-2.8
Alzheimer’s Disease (in father)	0.6	0.6	1.4	0.9	-0.6	0.6	-1.2	-0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	0.8	-1.6	0.9	-0.0	-0.9
Crohns Disease (2017)	0.5	1.0	2.9	-1.0	-0.6	1.7	-1.0	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	0.2	0.1	1.0	0.6	0.3
Ulcerative Colitis (UC)	0.5	1.0	3.5	1.1	0.4	-0.3	1.9	0.4
Major Depression (MDD)	1.7	2.1	4.7	-0.7	1.6	-0.8	1.3	2.2
Reaction Time	9.3	17.8	33.7	-5.8	5.2	0.1	-0.4	5.3
Verbal and Numeric Reasoning (VNR)	3.2	7.7	18.1	1.9	-0.0	4.0	-4.2	-0.9
Breast Cancer	0.1	0.2	0.5	0.7	0.1	-0.2	-0.6	-0.0
Ovarian Cancer	0.8	1.0	2.5	1.6	-1.3	-0.5	-0.2	-0.7
Prostate Cancer	1.3	1.8	4.3	0.0	0.3	2.1	-2.0	0.5
Age at First Birth	2.1	3.1	6.1	-2.0	2.5	0.2	-0.1	2.2
Bipolar Disorder (2011)	0.6	0.6	2.1	-0.3	1.4	0.1	-0.4	0.9
Body Mass Index (BMI) (2010)	1.2	1.7	4.2	0.8	-2.0	-0.2	0.1	-1.9
Coronary Artery Disease (CAD)	0.5	0.6	1.3	0.5	-1.1	0.2	0.0	-1.1
Crohns Disease (2012)	0.7	1.1	1.7	0.8	-1.3	0.8	-1.1	-1.0
Mean Putamen Volume	0.8	0.9	1.7	1.1	-0.8	-1.3	0.9	-0.6
Fasting Glucose	0.3	0.4	1.4	0.3	0.4	-1.2	0.5	0.4
HbA1C	0.6	0.7	2.0	0.4	0.5	-1.4	1.0	0.1
HDL Cholesterol	0.1	0.2	0.7	0.9	-0.0	-0.1	0.6	-0.1
LDL Cholesterol	0.6	0.9	2.4	0.8	-0.4	-1.6	0.8	-0.7
Lupus	0.5	0.7	3.2	-1.8	0.2	-0.2	0.6	-0.1
Neuroticism (2016)	2.6	3.8	5.4	-2.3	1.7	-1.9	1.3	2.3
Primary Biliary Cirrhosis	1.1	1.5	2.7	0.2	1.6	0.5	-1.4	1.6
Rheumatoid Arthritis	1.0	1.3	2.7	-1.6	0.5	-1.6	-0.4	0.9
Schizophrenia (2014)	0.4	1.0	2.3	0.8	0.4	-1.1	1.5	0.6
Triglycerides	0.8	1.3	2.1	0.6	-1.4	-1.3	0.4	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	-0.4	-1.2	-0.4	0.1	-1.4
Ulcerative Colitis	1.1	1.7	2.8	-0.2	1.6	-0.7	1.7	1.5
Blood Eosinophil Count	0.8	5.8	11.2	1.3	-3.4	-1.6	1.6	-3.3
Blood Platelet Count	0.1	1.1	2.0	1.4	-1.4	-0.6	0.3	-1.2
Blood Red Count	0.1	1.0	1.7	0.8	-0.7	1.1	-1.3	-0.9
Blood White Count	0.3	2.5	4.9	2.0	-1.7	-0.4	-0.7	-2.2
Heel T-Score	0.1	0.9	1.6	0.7	-0.9	1.0	-1.3	-0.9
BMI	0.8	4.8	11.0	-0.9	-2.2	-3.3	1.6	-2.2
Height	0.2	4.6	17.6	4.2	-0.5	-0.6	1.2	1.8
Waist Hip Ratio (WHR)	2.1	9.3	23.9	1.6	-4.9	-1.0	0.6	-4.3
Systolic Blood Pressure	0.6	2.8	7.5	-2.7	0.2	-2.1	1.4	0.2
Smoking Status	0.8	1.9	4.0	1.6	-1.8	0.3	0.1	-2.0
Allergy or Eczema	0.1	0.3	0.7	0.3	-0.4	0.4	0.8	-0.5
Cardiovascular Disease	0.7	2.2	3.4	-1.5	-1.0	-1.8	1.8	-1.1
Hypothyroidism (self reported)	0.3	0.6	1.3	-1.0	-1.1	-0.5	0.2	-0.6
Respiratory disease	0.4	0.8	1.6	0.6	-1.3	-0.2	0.9	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	-1.3	-0.8	-1.2	0.3	-1.0
Lung FEV1/FVC ratio	0.1	0.4	0.7	-0.8	-0.4	-0.3	-0.8	-0.8
Lung FVC	0.4	2.0	3.8	1.6	0.7	1.6	-2.0	0.9
Neuroticism	4.9	11.8	21.9	-4.5	3.8	0.6	-1.3	4.7
Chronotype (morning person)	0.2	0.4	1.2	0.2	-0.3	0.2	-1.1	-0.7
Hair Pigment	0.1	1.5	3.4	-0.2	1.2	1.9	-1.1	1.3
Tanning	0.2	2.1	4.0	1.7	-1.4	0.9	-1.0	-2.0
Hand grip strength (left)	1.6	4.2	10.3	0.2	0.4	-3.2	3.2	0.4
Number of treatments/medications taken	2.0	3.6	6.6	-1.5	-1.7	-2.1	2.6	-1.3
Average weekly spirits intake	0.4	0.5	1.3	-1.1	0.5	-0.3	-0.5	0.8
Sensitivity / hurt feelings	3.0	5.1	9.7	-3.1	2.5	-0.8	-0.2	3.0
Frequency of depressed mood in last 2 weeks	7.7	10.7	20.1	-4.5	3.6	0.6	-2.0	4.0
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.3	-0.3
Relative age of first facial hair	0.6	1.1	2.0	-1.4	1.4	0.6	-0.8	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.4	-0.9	-0.3	0.7	-1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.7	3.7	-0.1	1.1	-1.7	1.9	1.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.0	-1.2	-0.1	-1.0	-0.9
Systolic blood pressure, automated reading	0.3	0.8	2.0	-1.4	-0.5	-1.0	0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	-1.1	1.1	-0.3	0.7	0.9
Angina	1.1	1.4	2.6	-1.6	0.5	-1.4	1.4	0.5
Medication for hormone replacement therapy	1.7	1.9	4.1	1.9	-0.5	-1.1	2.0	-0.8
Vitamin and mineral supplements	0.7	1.0	2.3	0.3	-1.5	-0.4	-0.4	-1.4
Supplements: Zinc	0.8	0.9	2.3	-0.3	-0.0	1.5	-1.4	0.1
Medication: Co-codamol	0.9	1.1	1.7	-1.3	1.2	-0.0	-1.1	1.1
Medication: Metformin	0.2	0.3	1.5	-1.2	0.1	-0.2	0.4	-0.1
Diabetes (father)	1.4	1.7	3.0	1.3	-1.7	-1.0	0.2	-1.7
Diabetes (mother)	1.1	1.4	4.0	-2.0	0.1	-1.7	0.3	0.2
Severe depression (siblings)	0.2	0.2	0.3	-0.2	0.5	-0.6	0.0	0.6
Pack years adult smoking proportion	0.3	0.4	0.7	0.8	-0.8	0.2	-0.4	-0.6
Impedance of leg (right)	0.4	2.0	5.4	2.3	-1.3	1.0	-0.3	-1.3
Leg fat-free mass (left)	0.4	2.0	7.4	-1.0	-0.1	-2.7	1.0	0.7
Trunk fat percentage	1.8	7.4	14.4	1.1	-3.3	-3.8	1.4	-2.9
Hand grip strength (right)	0.6	1.6	4.7	-0.2	-0.3	-1.7	2.2	-0.4
Townsend deprivation index at recruitment	0.5	0.6	2.3	-0.9	0.2	0.2	-1.5	0.1
Current tobacco smoking	1.4	2.3	5.6	0.8	-2.1	0.4	0.6	-2.4
Average weekly fortified wine intake	0.3	0.4	1.5	-0.1	0.3	0.3	1.2	0.3
Maternal smoking around birth	0.5	0.8	1.5	1.2	-0.9	-0.9	0.1	-0.9
Fed-up feelings	3.6	6.6	13.4	-3.3	2.9	0.6	-0.3	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	7.2	-2.7	1.9	1.2	-2.3	2.0
Relative age voice broke	1.2	1.9	3.3	-0.9	1.8	0.6	-1.8	1.3
Taking other prescription medications	1.3	2.0	3.1	-1.8	-1.2	-1.5	1.6	-0.9
Age when periods started (menarche)	1.3	3.2	4.4	-1.4	2.1	-2.1	1.1	2.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.3	-0.2	-0.1	-1.2	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.5	0.7	-0.4	1.6	-0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.2	-0.7	0.2	0.0	-0.7
Qualifications: CSEs or equivalent	1.6	2.1	3.9	-2.0	2.0	-0.6	-0.1	1.5
Serious illness, injury or assault to yourself	0.5	0.6	2.1	0.3	-0.5	-1.5	0.9	0.0
High blood pressure	0.8	2.1	3.6	-1.4	-0.9	-1.9	1.8	-1.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.3	0.5	0.6	0.7	0.0
Multivitamins +/- minerals	0.4	0.5	1.1	0.4	1.1	-0.0	0.6	1.1
Stomach or abdominal pain in last month	1.1	1.4	2.4	-1.5	1.0	-1.0	0.4	1.5
Supplements: Glucosamine	1.2	1.6	2.5	1.6	-1.2	-0.6	1.3	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	-0.3	0.2	-0.5	0.9	0.7
Medication: Atenolol	1.7	2.1	5.6	-2.4	1.0	-0.1	1.7	0.9
Medication: Levothyroxine sodium	0.4	0.7	1.8	-0.6	-1.4	-0.7	0.7	-0.3
Sitting height	0.2	1.1	4.9	2.2	-0.7	-0.2	-0.0	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.0	1.1	1.0	-0.7	0.7
High blood pressure (mother)	0.9	1.3	2.2	-0.3	1.2	-1.4	0.8	1.5
Body mass index (BMI)	0.8	3.3	9.5	-1.0	-1.6	-3.1	1.0	-1.5
Impedance of leg (left)	0.4	1.9	5.3	2.3	-1.4	0.6	-0.0	-1.5
Leg predicted mass (left)	0.4	2.1	7.9	-1.1	-0.1	-2.8	1.0	0.7
Trunk fat mass	1.5	6.4	13.6	1.0	-3.1	-3.7	1.3	-2.5
Waist circumference	1.8	6.5	12.2	0.6	-3.5	-3.0	0.6	-3.2
Number of incorrect matches in round	0.9	1.4	2.1	-1.3	1.3	-0.6	1.2	1.5
Past tobacco smoking	0.5	0.9	2.6	-1.1	0.4	-0.8	1.6	0.3
Alcohol usually taken with meals	1.6	2.6	8.1	1.3	-0.1	2.8	-1.7	-0.6
Nervous feelings	4.5	8.3	15.1	-3.9	3.6	0.5	-0.2	3.6
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	8.5	-2.5	2.8	0.6	-0.3	2.9
Hearing difficulty/problems with background noise	0.7	1.1	1.9	-1.1	0.9	-0.4	1.2	1.4
Hair/balding pattern: Pattern 2	1.4	1.7	3.5	-1.0	1.9	0.6	-0.8	1.8
Had menopause	0.4	0.5	1.3	0.2	-1.1	-0.4	0.3	-1.0
Had other major operations	0.4	0.5	1.0	0.5	-1.0	-0.5	0.2	-1.0
Forced vital capacity (FVC)	0.3	1.1	2.1	1.1	0.5	0.4	-1.5	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.0	0.7	-0.1	1.4	-0.8	-0.3
Ever unenthusiastic/disinterested for a whole week	3.6	4.4	10.6	-3.3	2.0	-1.3	0.7	2.3
Qualifications: None of the above	1.7	3.5	6.0	-0.4	-2.4	-2.1	2.2	-1.5
Financial difficulties in last 2 years	1.5	2.1	6.1	-1.0	1.1	0.6	-2.5	1.2
Mouth/teeth dental problems	0.3	0.4	1.6	0.4	0.2	-0.7	1.2	0.2
Heart attack	0.7	0.9	1.9	-1.4	0.2	-1.0	1.1	0.5
Allergy	0.1	0.3	0.8	0.4	0.2	-0.2	-0.9	0.6
Pain all over the body in last month	0.5	0.5	1.0	-0.7	-0.9	-0.2	1.0	-0.5
Diabetes (self-reported)	0.4	0.6	1.0	-0.8	-0.6	-1.0	0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	7.6	0.0	0.6	2.8	-1.9	0.4
Medication: Ramipril	1.4	1.8	4.7	0.1	-0.9	-1.6	2.2	-0.9
Medication: Simvastatin	0.4	0.6	1.8	0.0	-0.3	-1.0	1.4	-0.3
Fluid intelligence score	4.0	8.3	21.0	1.8	-0.0	4.1	-4.6	-0.7
Illnesses of siblings	0.9	1.2	4.8	2.2	-0.2	0.9	0.7	0.1
Neuroticism score	4.8	9.9	18.5	-4.3	3.7	-0.3	-0.6	4.2
Weight	0.6	3.2	10.0	0.2	-1.9	-3.2	1.1	-1.1
Impedance of arm (right)	0.3	1.3	5.2	2.3	-0.6	-0.5	0.6	-0.5
Arm fat percentage (right)	1.5	5.9	14.6	0.6	-2.6	-3.8	1.4	-2.5
Trunk fat-free mass	0.1	0.6	1.8	-0.2	0.0	-1.4	0.5	0.9
Hip circumference	0.3	1.4	5.6	0.1	-0.9	-2.4	0.6	-0.7
Time employed in main current job	1.9	2.2	4.7	2.1	-0.0	-1.3	2.2	-0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.6	-0.3	1.2	-0.3	-0.0	1.1
Father’s age at death	1.0	1.4	2.4	0.4	1.4	0.6	1.3	1.5
Worrier / anxious feelings	4.0	7.5	13.3	-3.3	3.2	-1.0	-1.4	3.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-1.2	-0.0	0.5	-1.0	0.6
Falls in the last year	0.1	0.1	0.2	-0.4	0.0	-0.0	-0.5	0.3
Hair/balding pattern: Pattern 3	0.3	0.5	0.7	0.7	-0.4	0.9	-0.8	-0.7
Number of live births	0.2	0.3	0.7	-0.8	0.5	0.6	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.2	0.6	0.3	-0.1	-1.5	0.9
Pulse rate	1.4	2.4	4.2	2.1	-1.1	-1.5	1.6	-1.3
Happiness	1.7	2.1	4.1	-1.8	1.7	-0.6	0.1	2.0
Noisy workplace	1.3	1.6	4.1	-2.0	0.7	-1.4	0.0	1.2
Qualifications: A levels/AS levels or equivalent	2.3	5.1	13.7	0.9	1.0	3.7	-3.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.8	1.0	0.8	-1.4	1.0
Mouth/teeth dental problems: Dentures	1.6	2.6	7.0	0.1	-2.6	-0.4	0.4	-2.4
Asthma	0.5	1.0	1.4	1.0	-1.1	-0.6	1.0	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.1	1.6	-1.6	-0.6	-1.4	-1.8
Medication: Cholesterol lowering	1.0	1.6	4.9	-0.7	-0.3	-1.6	2.2	-0.4
Depression (self-reported)	0.5	0.7	1.6	-0.3	-0.3	-1.2	1.3	-0.1
Medication: Lansoprazole	0.9	1.1	3.4	0.1	-1.8	-0.3	-0.5	-1.3
Prospective memory result	3.3	4.0	13.2	-0.5	-0.0	-2.6	3.6	-0.2
Lung cancer (father)	0.2	0.2	0.7	-0.8	0.1	-0.5	0.0	-0.1
Illnesses of mother	0.1	0.1	0.5	0.3	0.1	0.0	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.1	0.3	0.5	-0.2	-0.9	1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	1.2	-0.7	0.4	0.3	-0.7
Impedance of arm (left)	0.3	1.5	6.2	2.5	-0.8	-0.1	0.5	-0.6
Arm fat mass (right)	1.1	4.4	12.2	0.1	-2.2	-3.5	1.1	-1.9
Trunk predicted mass	0.1	0.6	1.8	-0.2	0.0	-1.3	0.4	0.9
Standing height	0.2	1.6	6.2	2.5	-0.3	-0.7	0.5	1.1
Length of working week for main job	0.6	0.6	2.4	-1.5	0.4	-0.1	-0.6	0.4
Exposure to tobacco smoke at home	1.8	2.0	5.3	-0.5	-0.4	-2.3	2.1	-0.3
Breastfed as a baby	0.3	0.4	0.8	0.4	0.2	0.9	-0.9	0.2
Tense / ‘highly strung’	1.5	2.5	4.1	-2.0	2.0	-0.0	-1.2	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	5.8	-2.4	2.2	-0.9	0.7	2.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-0.5	-0.7	-0.7	1.3	-0.1
Birth weight of first child	0.4	0.7	2.5	1.6	-0.2	-0.2	-1.0	-0.3
Peak expiratory flow (PEF)	0.3	0.7	1.2	0.8	0.8	0.0	-1.1	1.1
Pulse wave reflection index	0.1	0.2	0.5	-0.7	-0.4	0.5	0.2	-0.2
Ever highly irritable/argumentative for 2 days	2.2	2.7	6.6	-2.6	1.7	0.8	-1.0	1.6
Loud music exposure frequency	0.2	0.2	0.6	-0.8	0.1	-0.5	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	7.9	-0.0	1.8	2.8	-2.4	1.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.0	0.7	1.0	1.0	-0.6	0.8
Blood clot in the leg (DVT)	1.4	1.8	5.3	0.6	-0.9	-2.3	1.4	-0.8
Medication: Paracetamol	0.5	0.8	1.4	0.8	-1.2	-0.5	0.6	-1.1
Headache pain in last month	0.9	1.6	3.1	-1.3	1.6	-0.1	-0.6	1.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.3	1.3	0.8	1.8	-1.7	0.9
Glaucoma (self-reported)	0.5	0.6	1.5	-0.5	0.9	-0.5	0.6	1.2
Gout (self-reported)	0.4	0.5	1.0	1.0	-0.6	-0.3	-0.1	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.7	-0.7	-1.6	-0.7	0.2	-0.7
Medication: Amlodipine	0.2	0.3	0.5	0.5	-0.6	-0.7	0.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.3	-0.7	-0.5	1.0	-1.8	-0.4
Birth weight	1.2	2.6	6.9	-0.5	2.2	-0.2	-0.9	2.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.2	0.3	-0.4	0.2	0.4
High blood pressure (siblings)	0.3	0.5	1.1	-1.0	-0.1	0.0	-1.1	-0.4
Forced vital capacity (FVC), Best measure	0.3	0.9	2.8	0.5	0.9	0.2	-0.8	1.7
Body fat percentage	1.9	7.6	14.7	0.9	-3.3	-3.8	1.5	-3.0
Leg fat percentage (right)	1.7	6.3	10.4	0.5	-3.2	-3.2	1.3	-3.0
Arm fat-free mass (right)	0.1	0.8	3.0	-0.4	-0.6	-1.7	0.5	0.1
Exposure to tobacco smoke outside home	0.9	1.2	2.6	-1.6	1.1	0.5	-0.6	1.2
Comparative body size at age 10	0.3	0.8	1.8	-1.4	-0.9	-0.4	-0.6	-0.9
Number of full brothers	0.1	0.1	0.3	0.2	0.6	-0.5	0.2	-0.0
Worry too long after embarrassment	2.8	4.6	7.7	-2.8	2.5	0.2	-1.3	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.1	-1.2	1.2	-1.3	2.0	1.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.7	-0.9	0.2	-0.1	-0.7
Number of children fathered	1.6	1.8	2.7	1.3	-1.5	1.5	-0.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.9	-0.3	0.6	-1.3	2.0	0.7
Age at first live birth	2.2	3.8	9.2	0.2	2.0	3.0	-1.8	1.7
Pulse wave peak to peak time	0.5	0.6	1.4	-1.2	0.8	-0.5	-0.2	0.8
Health satisfaction	0.4	0.5	1.0	-0.9	0.3	0.5	-1.0	0.5
Shortness of breath walking on level ground	0.7	0.9	2.2	-0.9	0.4	-0.9	1.5	0.6
Qualifications: College or University degree	0.7	2.2	5.6	2.1	0.4	2.4	-0.7	-0.7
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.6	-0.3	-0.5	0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.9	-1.1	0.2	-0.7	-1.3
Emphysema/chronic bronchitis	0.4	0.5	1.6	-0.0	-1.3	0.1	-0.4	-0.8
Medication for pain relief, constipation, heartburn	1.3	2.2	4.1	-0.5	2.0	1.2	-1.4	1.7
Neck or shoulder pain in last month	1.2	1.7	3.3	-1.8	1.4	-1.3	0.1	1.3
Medication: Blood pressure	1.0	1.8	4.0	-2.0	-0.6	-1.6	1.2	-0.7
Angina (self-reported)	1.0	1.4	2.7	-1.6	0.7	-1.2	1.3	0.7
Migraine (self-reported)	0.6	0.7	1.7	1.3	-0.5	-1.2	0.2	0.0
Medication: Ibuprofen	1.7	2.0	3.9	1.0	-2.0	-1.1	-0.3	-2.0
Medication: Allopurinol	0.2	0.2	0.7	-0.5	0.2	-0.4	-0.8	0.1
Medication: Omeprazole	0.9	1.1	2.1	-0.7	-1.0	-1.5	1.4	-0.4
Medication: Seretide 50 evohaler	0.5	0.5	2.3	1.5	-0.4	-0.2	0.1	-0.4
Mean time to correctly identify matches	4.9	9.4	19.2	-4.4	3.7	0.5	-0.6	3.7
Heart disease (mother)	1.2	1.5	3.8	-1.6	0.0	-1.9	1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.0	0.3	-0.5	0.4	0.1
Whole body fat mass	1.4	6.0	13.8	0.5	-2.9	-3.7	1.5	-2.4
Leg fat mass (right)	1.4	5.6	13.2	0.3	-2.6	-3.6	1.6	-2.3
Arm predicted mass (right)	0.2	1.0	3.7	-0.4	-0.8	-1.9	0.6	0.1
Pulse rate, automated reading	2.5	8.0	12.5	2.6	-2.4	-3.5	2.9	-2.6
Alcohol intake frequency.	0.2	0.5	1.3	-0.9	-0.0	0.6	-1.1	0.1
Comparative height size at age 10	0.1	0.3	0.7	0.2	-0.7	-0.4	-0.8	0.4
Number of full sisters	1.9	2.4	9.0	-1.0	-0.2	-3.0	1.3	-0.2
Suffer from ‘nerves’	1.2	1.8	4.1	-2.0	1.4	0.0	-0.6	1.6
Overall health rating	0.6	1.4	3.3	-1.7	-0.9	-1.8	0.0	-0.1
Chest pain or discomfort	0.2	0.2	1.1	-0.1	0.1	-0.1	1.1	0.3
Had major operations	2.5	3.0	6.8	0.9	-1.6	2.6	-1.7	-1.4
Age at last live birth	1.4	2.0	5.3	-0.8	1.1	2.3	-1.3	1.2
Family relationship satisfaction	0.7	0.8	2.0	-0.5	1.0	0.8	0.6	1.4
Leg pain on walking	0.7	0.8	2.3	-1.0	-0.8	-0.3	-1.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	-0.6	1.5	-0.2	-0.3	1.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.2	-0.7	0.3	1.9	-2.0	0.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	1.3	-1.1	-0.3	1.7	-1.4
Medication: Aspirin	1.8	2.4	4.3	0.3	-2.0	-0.8	2.1	-1.8
Supplements: Vitamin C	1.6	1.9	3.5	-1.7	1.6	0.8	-0.0	1.9
Knee pain experienced in last month	0.1	0.1	0.4	0.3	-0.2	-0.2	-0.7	-0.4
Hypertension (Self-reported)	0.8	2.1	3.9	-1.3	-1.0	-2.0	1.7	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	9.8	-0.2	-2.5	-3.1	1.8	-1.9
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.8	-0.0	0.1	-0.5	-0.1
Illnesses of siblings: Diabetes	3.8	4.6	10.8	-1.9	1.6	-3.3	2.2	1.2
Smoking status: Previous	0.4	0.6	1.5	1.1	0.0	0.3	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.9	-0.6	0.3	-1.0	0.7	0.9
Whole body fat-free mass	0.2	1.2	4.2	-0.7	-0.0	-2.0	0.7	0.8
Leg fat-free mass (right)	0.4	2.3	8.4	-1.1	-0.0	-2.9	1.2	0.8
Arm fat percentage (left)	1.5	5.8	12.7	0.6	-2.7	-3.6	1.4	-2.5
Average weekly red wine intake	0.7	1.0	2.0	1.1	-0.8	1.4	-0.3	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.1	0.3	-0.7	-1.1	1.4	-0.0
Mood swings	2.3	4.2	12.8	-3.6	1.6	0.1	-1.3	2.0
Loneliness, isolation	2.0	2.7	6.1	-1.8	1.7	-1.0	0.5	2.5
Long-standing illness, disability or infirmity	0.9	1.4	2.0	-1.4	-1.2	-1.1	1.4	-0.6
Ever had bowel cancer screening	0.3	0.4	1.1	0.2	-0.2	0.8	-1.0	0.2
Diabetes diagnosed by doctor	0.5	0.8	1.4	-1.0	-1.1	-0.6	0.1	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.3	1.1	-0.7	1.1	0.7	-0.7
Friendships satisfaction	0.8	1.0	1.9	-0.4	1.4	1.0	-0.8	1.1
Qualifications: nursing, teaching	2.1	3.2	6.9	0.9	1.5	2.5	-2.6	0.5
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.6	0.1	-1.0	-0.3	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.2	0.5	0.4	0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.8	0.2	0.5	-0.4	-1.3	0.5
Medication for cholesterol	2.0	3.0	6.9	-1.5	1.0	1.9	-2.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.2	6.9	1.5	-2.6	-1.9	2.1	-1.9
Back pain experienced in last month	0.8	1.1	3.2	0.1	-1.8	0.6	-0.8	-1.2
Mineral and other dietary supplements	0.1	0.1	0.4	-0.3	0.3	0.3	-0.6	0.1
Breast cancer (self-reported)	1.1	1.3	2.2	0.7	-1.5	-0.7	1.2	-1.3
Asthma (self-reported)	0.3	0.5	0.9	0.7	-0.7	-0.5	0.9	-0.8
Osteoporosis (self-reported)	1.9	2.4	3.3	-1.5	1.7	-1.0	1.8	1.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.0	-0.3
Medication: Aspirin	1.6	2.1	4.9	-0.4	-1.7	-0.9	2.2	-1.4
Medication: Gliclazide	0.2	0.2	0.7	-0.9	-0.3	-0.3	0.2	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.0	0.6	0.0	0.6	0.6
Smoking status: Current	1.5	2.3	6.0	0.8	-2.1	0.2	0.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.8	-0.7	1.4	1.1	-1.4	1.7
Whole body water mass	0.2	1.1	3.9	-0.7	0.1	-2.0	0.6	1.0
Leg predicted mass (right)	0.4	2.3	8.2	-1.1	0.0	-2.9	1.2	0.8
Arm fat mass (left)	1.2	5.1	12.5	0.6	-2.6	-3.5	1.1	-2.2
Number of self-reported non-cancer illnesses	1.6	2.7	5.4	-1.8	-0.6	-2.1	2.3	-0.4
Average weekly champagne plus white wine intake	2.4	3.3	8.9	3.0	-1.6	-0.7	1.4	-1.6
Miserableness	2.3	3.9	5.3	-2.3	1.8	0.9	-2.3	2.2
Guilty feelings	0.1	0.2	0.4	0.5	0.4	-0.6	0.2	0.4
Wears glasses or contact lenses	2.0	2.3	5.9	1.1	-2.4	-0.3	-0.1	-2.0
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.1	0.5	0.9	-0.3	0.6
Hearing aid user	0.2	0.3	1.0	1.0	0.1	0.5	-0.2	0.2
Mother’s age at death	0.3	0.4	1.1	1.1	0.1	0.4	0.9	0.0
Financial situation satisfaction	2.3	2.9	9.2	-3.0	1.4	-0.1	-0.4	1.8
Tinnitus: Yes, now most or all of the time	3.2	3.7	7.8	1.0	-1.5	-2.8	2.5	-1.1
Commuting to job workplace: Public transport	2.2	2.6	4.4	2.1	-2.0	-0.5	0.6	-2.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.9	0.6	-0.2	0.3	1.0
Medication: Blood pressure	1.3	2.6	6.9	1.0	-0.8	-1.9	2.6	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-1.1	-0.8	-0.3	-0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	0.1	0.0	-0.7	1.5	0.4
High cholesterol (Self-reported)	1.0	1.7	6.5	0.1	-0.9	-0.7	2.5	-0.8
Medication: Bendroflumethiazide	1.4	2.1	6.8	0.1	-0.4	-1.9	2.6	-0.1
Medication: Paracetamol	0.8	1.2	2.9	0.5	-1.7	-0.3	0.8	-1.5
Medication: Lisinopril	1.3	1.6	3.3	-1.6	-0.5	-1.8	1.3	-0.4
Medication: Atorvastatin	0.3	0.4	1.0	-1.0	-0.7	0.3	0.1	-0.5
Illnesses of father: High blood pressure	1.1	1.4	3.3	0.9	-0.4	-1.8	1.6	-0.3
Alcohol drinker status: Never	2.7	3.2	4.0	1.6	-1.6	1.7	-2.0	-2.0
Ever smoked	0.5	0.8	2.0	0.4	0.2	1.4	-1.2	0.6
Basal metabolic rate	0.2	1.3	5.5	-0.5	-0.5	-2.3	0.7	0.3
Leg fat percentage (left)	1.9	6.7	11.7	0.5	-3.2	-3.4	1.5	-3.0
Arm fat-free mass (left)	0.2	1.3	5.3	-0.4	-0.6	-2.3	0.7	0.2
Number of operations (self-reported)	1.0	1.5	3.7	0.5	-1.9	0.4	-0.5	-1.7
Average weekly beer plus cider intake	0.7	1.1	1.5	-0.9	-1.2	-1.2	0.6	-1.1
Irritability	4.9	8.2	13.0	-3.2	3.6	1.8	-1.6	3.5
Risk taking	2.2	3.2	6.7	1.5	-2.6	-0.4	-0.7	-2.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.2	-0.1	0.7	1.5	-0.3	0.5
Fractured/broken bones in last 5 years	0.5	0.7	1.3	1.1	-0.9	0.5	-0.6	-0.8
Age started oral contraceptive pill	0.7	0.9	2.0	0.0	-0.8	-1.4	1.0	-1.0
Diastolic blood pressure, automated reading	0.4	1.2	2.9	-0.2	-1.7	-1.3	0.3	-1.1
Ever depressed for a whole week	1.6	1.9	3.0	-1.7	1.4	-1.4	0.9	1.4
Unable to work because of sickness or disability	1.4	1.8	5.1	-0.7	-0.6	-2.3	1.7	-0.3
Commuting to job workplace: Cycle	0.4	0.5	1.8	0.4	0.2	1.3	-0.5	0.4
Myopia	0.7	1.1	2.2	1.1	-0.0	1.5	-1.4	0.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.3	2.1	0.4	1.6	-1.8	0.5
Cholesterol lowering medication	1.6	2.3	4.5	1.6	-2.1	-0.6	0.2	-2.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.4	0.1	-1.8	-1.2	0.9	-1.3
Pain experienced in last month	0.8	1.3	4.3	2.1	-0.7	0.5	0.7	-1.1
Supplements: Calcium	2.3	2.5	4.4	-1.4	1.5	2.1	-0.6	1.9
Basal cell carcinoma (self-reported)	2.1	2.5	5.2	2.3	-1.7	0.8	-0.6	-1.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.5	-1.9	0.7	-0.8	1.1	1.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.3	1.0	-1.1	-2.3	1.6	-1.1
Heart disease (siblings)	0.5	0.7	2.5	-1.6	0.1	-0.8	0.2	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.6	-0.2	-0.1	-0.2	0.8	0.2
Pack years of smoking	0.3	0.5	0.9	0.9	-0.9	0.2	-0.7	-0.5
Impedance of whole body	0.3	1.6	6.4	2.5	-1.0	0.3	0.0	-0.9
Leg fat mass (left)	1.5	5.9	14.6	0.3	-2.6	-3.8	1.7	-2.3
Arm predicted mass (left)	0.1	0.7	3.0	-0.3	-0.6	-1.7	0.2	0.1