Hub : Genes

CCND2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1330 0.0480 7.6e-03 0.069 0.000 0.043 0.058 0.081 7.9e-09 3.0e-01 5.6e-06 1.3e-07 4.2e-10
2 METSIM Adipose 0.0648 0.0239 2.3e-03 0.027 0.019 0.024 0.021 0.012 5.8e-05 5.9e-04 1.5e-04 2.9e-04 6.2e-03
3 YFS Blood 0.0592 0.0162 9.2e-06 0.017 0.016 0.023 0.025 0.025 1.7e-06 4.4e-06 3.2e-08 1.3e-08 8.2e-09
4 TCGA Prostate Adenocarcinoma 0.2059 0.0594 2.3e-04 0.127 0.038 0.114 NA 0.122 3.5e-13 6.7e-05 6.7e-12 NA 1.1e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 2.4 -0.9 -0.0 -1.6 0.0
Bipolar Disorder or Schizophrenia 0.4 0.9 3.4 0.3 0.3 -1.8 0.0
Depressed Affect (Nagel 2018) 0.4 0.8 3.3 -0.0 0.2 1.8 0.0
Depression (Nagel 2018) 1.1 1.7 5.2 1.1 0.4 2.3 0.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 -0.8 0.8 -1.2 0.0
Neuroticism (Nagel 2018) 0.7 1.7 5.3 1.0 0.6 2.3 0.0
Schizophrenia (2018) 0.3 0.7 1.3 1.2 0.4 -1.1 0.0
Schizophrenia vs Biploar Disorder 0.8 1.0 1.6 1.3 0.9 1.2 0.0
Worry (Nagel 2018) 0.6 1.3 4.3 0.9 -0.1 2.1 0.0
Alzheimer’s Disease (in mother) 1.3 1.5 3.1 -1.2 -0.3 -1.8 1.1
Alzheimer’s Disease (in father) 0.4 0.5 1.7 -0.2 -0.5 0.1 1.3
Alzheimer’s Disease (including proxy) 1.2 1.8 3.2 -1.8 -1.0 -0.9 1.5
Crohns Disease (2017) 2.2 4.9 11.6 0.8 -0.6 2.6 -3.4
Irritable Bowel Disease (IBD) 0.6 1.5 3.6 1.0 0.0 1.2 -1.9
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.4 0.2 -0.4 0.6
Major Depression (MDD) 0.0 0.0 0.1 0.4 -0.1 -0.1 0.0
Reaction Time 0.8 1.5 2.8 -0.9 -1.7 0.9 -1.2
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.1 -0.9 0.0 -0.4 1.1
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.5 2.0 4.0 -1.0 -0.5 -2.0 1.7
Prostate Cancer 1.0 1.5 2.8 1.5 1.7 -0.5 0.6
Age at First Birth 0.5 0.7 1.9 0.8 0.6 -1.4 0.3
Bipolar Disorder (2011) 0.2 0.2 0.8 0.0 0.9 0.0 0.0
Body Mass Index (BMI) (2010) 2.0 2.8 5.2 1.8 0.7 2.3 -1.5
Coronary Artery Disease (CAD) 0.7 0.9 2.8 -0.3 -1.7 0.8 0.0
Crohns Disease (2012) 0.9 1.4 4.1 1.0 -0.7 2.0 0.0
Mean Putamen Volume 0.9 1.1 3.3 -0.4 0.1 -0.9 1.8
Fasting Glucose 1.4 1.7 2.8 1.4 1.2 -0.8 1.7
HbA1C 1.8 2.0 4.5 -0.4 -1.4 -2.1 1.1
HDL Cholesterol 0.9 1.4 4.2 0.2 0.0 -1.2 2.0
LDL Cholesterol 0.5 0.8 1.4 -1.0 -0.6 -1.2 0.6
Lupus 2.7 4.1 13.0 1.4 3.6 -1.3 0.0
Neuroticism (2016) 0.6 0.8 1.7 0.4 1.3 -1.1 -0.5
Primary Biliary Cirrhosis 0.5 0.7 1.4 -1.1 -0.6 1.2 0.0
Rheumatoid Arthritis 0.3 0.5 0.8 0.9 -0.6 0.8 0.0
Schizophrenia (2014) 0.2 0.4 1.4 0.4 -0.2 -1.2 0.0
Triglycerides 0.1 0.2 0.4 0.3 -0.6 -0.7 -0.3
Type 2 Diabetes (T2D) (2012) 5.5 6.4 11.7 -3.3 -1.7 -3.4 0.0
Ulcerative Colitis 0.7 1.0 2.0 1.4 1.4 -0.3 0.0
Blood Eosinophil Count 0.5 3.7 6.8 1.7 -0.7 2.6 -2.2
Blood Platelet Count 0.1 1.7 2.8 -0.7 -1.7 1.5 1.1
Blood Red Count 1.1 10.4 26.7 1.1 -5.2 3.7 -0.3
Blood White Count 1.2 9.1 19.5 3.4 -1.5 4.4 -1.8
Heel T-Score 0.7 5.4 8.9 -2.7 -1.7 -3.0 1.6
BMI 0.3 1.5 3.9 1.0 1.0 2.0 -0.4
Height 0.2 3.0 7.3 1.8 2.7 1.1 0.4
Waist Hip Ratio (WHR) 0.1 0.7 1.8 1.4 -0.7 -0.6 -0.0
Systolic Blood Pressure 0.4 2.1 4.8 -1.0 -1.6 0.4 -2.2
Smoking Status 0.8 1.8 4.9 -0.6 -2.2 -0.2 -1.5
Allergy or Eczema 0.2 0.4 0.7 -0.4 0.5 -0.7 0.8
Cardiovascular Disease 0.7 2.2 3.1 -0.8 -1.6 1.8 -1.6
Hypothyroidism (self reported) 0.5 1.2 3.5 0.4 1.9 -1.1 0.0
Respiratory disease 0.1 0.3 0.8 0.3 -0.9 -0.4 -0.5
Type 2 Diabetes (T2D) (2018) 1.9 3.5 11.2 -1.5 0.6 -3.3 0.6
Lung FEV1/FVC ratio 0.2 1.2 2.5 0.9 1.6 0.3 -1.2
Lung FVC 0.2 1.3 2.4 -0.6 1.6 0.6 1.4
Neuroticism 2.2 5.2 9.0 2.0 1.5 2.3 -3.0
Chronotype (morning person) 0.3 0.8 2.3 -0.9 -1.5 0.1 0.1
Hair Pigment 0.2 5.1 10.6 2.2 1.2 1.9 -3.3
Tanning 0.0 0.3 0.7 -0.8 0.0 -0.4 0.7
Hand grip strength (left) 0.3 0.7 1.1 0.8 -0.0 1.0 -1.1
Number of treatments/medications taken 0.8 1.4 3.6 -0.7 -1.1 0.6 -1.9
Average weekly spirits intake 2.2 2.7 7.6 1.3 2.8 0.1 -1.1
Sensitivity / hurt feelings 2.1 3.5 5.1 2.3 2.3 0.2 -1.9
Frequency of depressed mood in last 2 weeks 4.1 5.8 10.4 2.6 1.0 3.2 -2.3
Hearing difficulty/problems: Yes 0.4 0.6 1.8 -0.6 -1.3 0.2 -0.4
Relative age of first facial hair 0.2 0.5 0.9 1.0 0.5 0.8 -0.1
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.7 -0.8 -1.7 0.6 -0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.7 -1.7 -0.7 -0.3 -0.0
Ever had hysterectomy (womb removed) 1.4 1.6 4.0 0.3 -1.1 2.0 -1.1
Systolic blood pressure, automated reading 0.5 1.5 3.6 -1.9 -1.2 -0.4 -0.8
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 6.0 -0.4 0.4 -2.5 1.4
Angina 1.0 1.4 4.5 0.2 -0.1 2.1 1.0
Medication for hormone replacement therapy 1.3 1.5 2.3 -1.1 -1.1 -1.1 1.5
Vitamin and mineral supplements 0.5 0.7 1.0 -0.6 0.7 -0.9 -1.0
Supplements: Zinc 0.5 0.5 1.0 0.6 -0.7 1.0 -0.2
Medication: Co-codamol 2.9 3.3 5.3 2.3 1.3 1.7 -1.8
Medication: Metformin 1.7 2.4 6.9 -1.3 0.9 -2.6 0.7
Diabetes (father) 5.8 7.2 16.0 -1.7 0.4 -4.0 3.1
Diabetes (mother) 4.5 5.7 19.7 -1.0 1.1 -4.4 0.9
Severe depression (siblings) 0.5 0.6 1.1 -1.0 0.2 1.0 0.4
Pack years adult smoking proportion 0.6 0.9 2.8 -0.2 -0.8 1.7 -0.2
Impedance of leg (right) 0.2 1.2 2.9 -0.6 -0.6 -1.7 1.1
Leg fat-free mass (left) 0.5 2.8 4.9 2.2 1.9 1.6 -0.5
Trunk fat percentage 0.2 0.6 2.0 0.2 -0.1 0.6 1.4
Hand grip strength (right) 0.1 0.2 0.5 0.0 -0.4 0.7 -0.4
Townsend deprivation index at recruitment 1.1 1.5 5.3 -0.1 -0.6 0.5 -2.3
Current tobacco smoking 0.4 0.6 1.2 -0.1 -1.1 1.1 -0.3
Average weekly fortified wine intake 0.4 0.5 1.1 0.1 -0.0 1.0 1.1
Maternal smoking around birth 3.2 4.7 10.3 -3.2 -2.8 -0.1 -0.6
Fed-up feelings 2.3 4.3 10.7 1.6 1.4 1.3 -3.3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.9 5.3 11.2 1.8 -0.4 3.3 -2.6
Relative age voice broke 0.7 1.1 1.9 0.8 0.9 1.4 1.1
Taking other prescription medications 0.7 1.1 3.8 -0.7 0.1 0.1 -1.9
Age when periods started (menarche) 0.2 0.6 1.8 0.3 0.1 0.6 1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.7 0.8 -0.2 0.3 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 4.1 -2.0 -1.6 -1.3 1.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.4 -0.4 -0.4 1.2 0.0
Qualifications: CSEs or equivalent 1.1 1.4 4.1 1.0 -0.2 -0.7 -2.0
Serious illness, injury or assault to yourself 1.8 2.2 4.3 -0.5 -2.1 0.4 -2.0
High blood pressure 0.7 2.0 5.2 -1.4 -2.3 0.6 -0.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.1 0.0 0.6 -1.0 0.6
Multivitamins +/- minerals 0.6 0.8 1.4 0.7 -1.2 0.8 0.8
Stomach or abdominal pain in last month 1.0 1.3 4.4 0.6 0.0 2.1 -0.7
Supplements: Glucosamine 1.4 1.8 3.4 0.9 -0.3 -1.8 1.8
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.5 1.2 1.2 0.8 0.8
Medication: Atenolol 0.5 0.6 1.0 -0.7 -0.5 0.7 -1.0
Medication: Levothyroxine sodium 0.5 0.8 2.5 0.7 1.6 0.2 0.1
Sitting height 0.6 4.0 10.7 2.0 3.3 0.3 0.9
Chronic bronchitis/emphysema (father) 0.1 0.2 0.5 -0.7 -0.0 -0.1 -0.4
High blood pressure (mother) 0.4 0.5 1.1 -0.8 -0.5 -0.1 -1.1
Body mass index (BMI) 0.1 0.6 1.7 0.3 -0.4 1.3 -0.6
Impedance of leg (left) 0.3 1.3 3.3 -0.8 -0.7 -1.8 0.9
Leg predicted mass (left) 0.6 2.9 5.2 2.3 1.9 1.6 -0.4
Trunk fat mass 0.2 0.7 1.4 0.9 0.3 1.2 0.7
Waist circumference 0.1 0.5 1.2 0.3 -0.9 1.1 0.3
Number of incorrect matches in round 0.3 0.4 0.9 -0.8 -1.0 0.4 0.2
Past tobacco smoking 0.8 1.5 3.8 0.4 1.4 -0.4 2.0
Alcohol usually taken with meals 0.8 1.2 2.5 0.9 1.6 -0.3 1.3
Nervous feelings 0.7 1.3 2.8 0.8 -0.8 1.7 -1.1
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 9.0 1.6 0.5 3.0 -1.3
Hearing difficulty/problems with background noise 2.1 3.4 6.8 -0.9 -2.6 1.4 -2.1
Hair/balding pattern: Pattern 2 2.2 2.8 5.2 -1.7 -1.2 -1.2 2.3
Had menopause 1.4 1.8 5.3 -2.3 -0.5 -1.3 -0.1
Had other major operations 2.1 2.6 8.2 -0.2 -1.3 0.7 -2.9
Forced vital capacity (FVC) 1.5 5.8 16.3 2.5 4.0 0.8 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 4.6 -2.1 -0.7 -1.4 1.5
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 4.4 2.1 0.2 1.3 -1.3
Qualifications: None of the above 0.3 0.6 2.0 -1.4 -0.0 -0.1 -0.4
Financial difficulties in last 2 years 0.4 0.6 1.6 0.6 -0.5 -0.2 -1.2
Mouth/teeth dental problems 0.1 0.1 0.3 -0.1 0.5 0.2 0.2
Heart attack 0.2 0.2 0.3 -0.5 -0.6 -0.2 -0.6
Allergy 0.1 0.2 0.7 -0.4 -0.1 0.9 -0.2
Pain all over the body in last month 0.3 0.3 0.6 -0.6 -0.3 -0.8 -0.5
Diabetes (self-reported) 3.9 6.0 12.8 -2.5 -0.5 -3.6 2.1
Hayfever/allergic rhinitis (self-reported) 2.1 2.7 7.4 0.6 2.7 -1.8 0.3
Medication: Ramipril 0.3 0.4 1.1 -1.0 -0.0 0.5 0.4
Medication: Simvastatin 0.3 0.4 0.5 -0.5 -0.7 0.6 -0.6
Fluid intelligence score 0.1 0.3 0.6 -0.1 0.3 -0.7 0.8
Illnesses of siblings 1.7 2.5 6.6 2.6 1.7 -0.5 0.2
Neuroticism score 1.6 3.4 7.1 1.7 0.9 1.6 -2.7
Weight 0.4 1.9 3.2 1.7 1.1 1.8 -0.5
Impedance of arm (right) 0.5 2.2 7.0 0.8 1.2 -0.1 2.6
Arm fat percentage (right) 0.1 0.6 1.9 0.3 -0.5 1.4 0.3
Trunk fat-free mass 0.6 3.7 5.1 2.3 2.0 1.5 -1.9
Hip circumference 0.1 0.6 1.7 0.5 0.8 1.3 0.2
Time employed in main current job 1.0 1.1 2.2 -1.2 -0.8 0.1 -1.5
Alcohol intake versus 10 years previously 1.0 1.4 3.1 -1.2 -0.5 -1.0 -1.8
Father’s age at death 0.1 0.1 0.1 0.3 0.2 -0.2 -0.3
Worrier / anxious feelings 0.4 0.8 1.7 0.9 0.1 1.3 -0.9
Frequency of tiredness / lethargy in last 2 weeks 7.1 11.6 24.5 2.8 0.4 5.0 -3.7
Falls in the last year 1.1 1.5 2.3 1.5 0.8 1.0 -1.5
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 -0.8 -0.3 -0.3 0.5
Number of live births 1.1 1.5 2.6 -1.6 -1.3 -0.8 -1.1
Forced expiratory volume in 1-second (FEV1) 1.7 5.9 15.8 2.7 4.0 0.6 -0.5
Pulse rate 1.3 2.3 3.7 -1.9 -1.3 -1.9 -0.1
Happiness 1.4 1.7 4.1 1.2 0.4 1.1 -2.0
Noisy workplace 0.2 0.2 0.4 -0.2 -0.6 -0.6 0.2
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 0.6 0.7 0.1 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.4 -0.3 -0.5 -0.3
Mouth/teeth dental problems: Dentures 0.2 0.4 1.4 0.3 -0.2 0.0 -1.2
Asthma 0.2 0.4 1.2 0.0 -1.1 -0.5 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 1.9 1.4 -0.9 1.4 -1.1
Medication: Cholesterol lowering 0.3 0.4 0.7 0.4 0.6 0.7 -0.8
Depression (self-reported) 1.0 1.2 2.5 0.5 0.1 1.4 -1.6
Medication: Lansoprazole 0.5 0.5 1.6 1.3 -0.4 0.4 -0.4
Prospective memory result 0.2 0.2 0.5 -0.0 -0.3 -0.7 0.4
Lung cancer (father) 0.7 0.9 3.2 0.3 0.2 1.8 0.3
Illnesses of mother 0.9 1.1 2.1 1.3 0.1 1.4 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.7 11.6 1.6 3.4 -0.3 0.6
Pulse wave Arterial Stiffness index 1.0 1.2 3.2 -1.1 -0.5 -0.3 -1.8
Impedance of arm (left) 0.6 2.9 9.9 0.3 0.9 -0.9 3.1
Arm fat mass (right) 0.2 0.8 2.4 0.8 0.2 1.6 -0.2
Trunk predicted mass 0.7 3.7 5.1 2.3 2.0 1.4 -1.9
Standing height 0.5 5.1 10.0 3.0 3.2 1.3 0.4
Length of working week for main job 1.0 1.1 1.7 0.9 1.0 1.3 -0.8
Exposure to tobacco smoke at home 0.7 0.8 2.0 0.9 1.4 0.4 0.4
Breastfed as a baby 0.3 0.4 0.8 -0.2 -0.9 0.6 -0.5
Tense / ‘highly strung’ 0.6 1.1 1.9 0.6 -1.1 1.4 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.8 1.7 0.4 0.6 -2.0
Hair/balding pattern: Pattern 4 0.4 0.9 2.8 0.7 -0.5 1.7 -0.2
Birth weight of first child 0.9 1.6 4.4 -0.5 2.1 -0.7 1.1
Peak expiratory flow (PEF) 1.0 2.2 6.1 1.6 2.5 0.4 -0.3
Pulse wave reflection index 1.8 2.2 4.5 2.1 1.4 0.1 -1.6
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.8 1.3 1.0 -0.3 -1.4
Loud music exposure frequency 0.8 0.9 1.9 -0.6 -1.4 -0.9 -0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.7 -0.7 -0.4 -0.4 -1.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.1 1.1 -0.6 1.0 -0.1
Blood clot in the leg (DVT) 0.7 0.9 2.8 -0.5 -0.5 -1.7 0.4
Medication: Paracetamol 2.7 4.5 11.0 -0.4 -1.4 2.2 -3.3
Headache pain in last month 2.5 4.3 10.0 1.7 1.1 1.8 -3.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 -0.3 -0.3 -0.4 -0.2
Glaucoma (self-reported) 1.3 1.5 3.0 -1.1 0.2 -1.3 1.7
Gout (self-reported) 0.7 1.0 1.6 0.9 1.2 0.9 0.8
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.6 -0.7 1.3 -1.0 0.7
Medication: Amlodipine 0.3 0.4 0.6 -0.7 -0.1 -0.8 0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 -0.0 0.0 -0.3 0.8
Birth weight 1.3 2.8 5.9 -0.4 0.8 -2.4 2.1
Chronic bronchitis/emphysema (mother) 2.2 2.6 7.0 1.5 -0.1 2.6 -1.1
High blood pressure (siblings) 0.8 1.2 2.5 -1.4 -1.6 0.7 -0.2
Forced vital capacity (FVC), Best measure 1.0 3.6 11.5 1.4 3.4 -0.4 0.9
Body fat percentage 0.1 0.4 0.6 0.2 -0.5 0.7 0.8
Leg fat percentage (right) 0.2 0.7 2.3 -0.5 -1.5 0.2 0.0
Arm fat-free mass (right) 0.4 1.9 2.7 1.6 1.3 1.0 -1.6
Exposure to tobacco smoke outside home 1.4 1.9 5.7 1.3 2.4 0.0 -0.4
Comparative body size at age 10 0.2 0.7 1.7 0.2 0.9 -1.3 0.5
Number of full brothers 0.3 0.4 1.4 -1.2 0.1 0.2 0.3
Worry too long after embarrassment 1.4 2.4 3.1 1.6 1.2 1.8 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 3.6 0.7 -0.2 1.9 -1.8
Wheeze or whistling in the chest in last year 0.3 0.6 1.2 -1.0 -1.1 0.1 -0.4
Number of children fathered 0.5 0.6 1.5 -0.9 0.1 -0.4 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.6 0.7 0.8 -0.0 -0.1
Age at first live birth 0.3 0.5 0.6 0.7 0.6 -0.8 0.6
Pulse wave peak to peak time 1.1 1.3 3.1 1.3 0.7 0.4 1.8
Health satisfaction 0.5 0.6 1.1 0.3 -0.4 1.1 -1.1
Shortness of breath walking on level ground 1.1 1.3 2.0 1.1 1.4 1.1 -0.8
Qualifications: College or University degree 0.2 0.7 1.3 0.4 0.6 1.0 1.1
Eye problems/disorders: None of the above 0.3 0.4 1.1 0.6 0.2 1.1 -0.2
Mouth/teeth dental problems: Loose teeth 1.4 1.7 4.3 -1.1 1.0 -2.1 -0.3
Emphysema/chronic bronchitis 2.2 2.4 4.7 1.1 -0.0 2.2 -2.0
Medication for pain relief, constipation, heartburn 3.0 5.1 12.6 -1.6 -0.8 -2.1 3.6
Neck or shoulder pain in last month 2.0 2.9 7.9 1.4 -0.5 2.8 -1.2
Medication: Blood pressure 0.3 0.6 1.1 0.5 -0.0 1.0 -1.0
Angina (self-reported) 1.2 1.6 5.2 -0.0 -0.5 2.3 0.9
Migraine (self-reported) 1.4 1.7 3.0 1.2 1.7 0.3 -1.5
Medication: Ibuprofen 0.7 0.9 1.4 0.7 -0.9 1.2 -0.8
Medication: Allopurinol 0.9 1.2 2.3 0.9 1.5 1.0 0.8
Medication: Omeprazole 0.8 1.0 3.4 -0.7 0.1 1.8 0.3
Medication: Seretide 50 evohaler 2.3 2.7 4.8 0.8 -1.1 2.0 -2.2
Mean time to correctly identify matches 1.0 1.9 2.9 -1.7 -1.5 0.6 -1.3
Heart disease (mother) 0.1 0.1 0.3 0.3 0.5 0.2 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.0 1.0 0.2 -1.4 -0.7
Whole body fat mass 0.1 0.5 1.3 0.8 0.2 1.1 0.3
Leg fat mass (right) 0.1 0.5 1.2 0.8 -0.3 1.1 -0.2
Arm predicted mass (right) 0.4 2.0 3.1 1.8 1.4 1.0 -1.4
Pulse rate, automated reading 0.3 1.0 2.0 -1.4 -0.7 -1.3 -0.2
Alcohol intake frequency. 0.2 0.4 0.7 -0.5 -0.8 0.6 -0.3
Comparative height size at age 10 1.4 7.6 10.4 3.2 2.5 1.8 -3.2
Number of full sisters 0.7 0.9 2.9 -0.5 -0.1 0.6 -1.7
Suffer from ‘nerves’ 1.0 1.6 3.1 0.7 0.1 1.7 -1.7
Overall health rating 2.1 4.6 9.9 -0.0 -2.0 2.1 -3.1
Chest pain or discomfort 1.3 1.8 2.9 0.2 -1.7 1.5 -1.5
Had major operations 0.5 0.6 1.2 0.8 0.1 0.6 -1.1
Age at last live birth 0.3 0.5 1.8 -0.2 -0.3 -1.4 -0.2
Family relationship satisfaction 0.3 0.3 0.7 -0.4 -0.6 0.2 -0.8
Leg pain on walking 1.7 2.1 3.2 -1.8 -1.6 0.5 -1.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 4.1 -0.9 -2.0 0.1 -0.5
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.3 -0.8 0.2 1.1 0.4
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.0 0.3 1.7 -0.0 1.7
Medication: Aspirin 1.2 1.6 3.0 0.8 0.6 1.7 -1.6
Supplements: Vitamin C 0.9 1.1 2.5 -0.0 -0.3 -1.3 1.6
Knee pain experienced in last month 0.2 0.3 0.5 0.7 -0.6 0.4 -0.2
Hypertension (Self-reported) 0.4 1.2 2.7 -0.6 -1.6 1.2 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.2 -0.5 0.8 -1.1 0.0
Illnesses of father: Heart disease 0.9 1.3 2.2 -1.5 -1.5 0.3 0.8
Illnesses of siblings: Diabetes 1.9 2.4 4.6 -2.1 -0.1 -1.9 1.1
Smoking status: Previous 1.0 1.5 4.4 -0.5 -1.2 0.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.0 1.4 0.5 -0.5 0.5
Whole body fat-free mass 0.5 3.1 4.9 2.2 1.9 1.5 -1.3
Leg fat-free mass (right) 0.5 2.7 4.5 2.1 1.8 1.6 -0.7
Arm fat percentage (left) 0.1 0.5 1.3 0.2 -0.5 1.1 0.5
Average weekly red wine intake 0.6 0.9 2.2 -0.0 1.0 -1.5 -0.5
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.9 -0.9 -0.8 1.4 0.1
Mood swings 0.3 0.6 1.4 0.3 -0.6 1.2 -0.6
Loneliness, isolation 1.6 2.2 4.9 1.0 0.5 1.7 -2.2
Long-standing illness, disability or infirmity 0.8 1.2 3.2 -0.7 -1.8 0.9 -0.7
Ever had bowel cancer screening 1.4 1.7 4.3 -1.1 0.2 -2.1 1.1
Diabetes diagnosed by doctor 3.8 6.3 15.8 -2.1 -0.3 -4.0 2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.4 1.6 0.5 0.0 -0.6
Friendships satisfaction 3.5 4.4 11.5 1.8 -0.6 1.6 -3.4
Qualifications: nursing, teaching 0.1 0.1 0.2 0.3 0.5 0.2 0.1
Commuting to job workplace: Walk 0.3 0.3 1.1 0.4 -1.0 0.1 -0.0
Eye problems/disorders: Cataract 2.1 2.5 6.0 -1.7 -0.9 0.6 -2.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.9 -0.8 -1.4 -0.2 -0.2
Medication for cholesterol 1.3 1.9 4.9 1.3 2.2 -1.0 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.0 1.7 1.5 -0.8 0.7
Back pain experienced in last month 3.4 5.0 7.5 2.7 1.4 2.0 -2.6
Mineral and other dietary supplements 0.6 0.8 1.2 -1.0 0.9 0.2 -1.1
Breast cancer (self-reported) 2.0 2.4 4.9 -2.1 -2.2 -0.1 0.8
Asthma (self-reported) 0.3 0.5 1.7 -0.2 -1.3 -0.4 -0.4
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.0 0.5 -0.2 -0.5
Osteoarthritis (self-reported) 0.3 0.4 1.0 0.7 0.0 -0.1 -1.0
Medication: Aspirin 0.6 0.8 1.9 0.5 0.6 1.4 -0.8
Medication: Gliclazide 5.4 6.1 19.7 -1.8 -0.5 -4.4 1.1
Illnesses of father: None of the above (group 1) 1.0 1.3 2.6 1.6 0.5 1.2 -0.9
Smoking status: Current 0.3 0.5 0.9 0.3 -0.9 1.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.6 -0.6 1.5 -1.9 0.8
Whole body water mass 0.5 3.1 4.8 2.2 1.9 1.5 -1.3
Leg predicted mass (right) 0.5 2.5 4.2 2.0 1.8 1.5 -0.7
Arm fat mass (left) 0.2 0.6 1.9 0.8 0.1 1.4 -0.1
Number of self-reported non-cancer illnesses 0.6 1.0 2.0 -1.4 -0.7 -0.6 -1.1
Average weekly champagne plus white wine intake 1.1 1.6 3.2 0.6 0.8 1.8 1.4
Miserableness 2.8 4.8 9.6 -0.4 -1.6 3.1 -2.7
Guilty feelings 0.4 0.6 1.0 0.7 0.8 0.7 -1.0
Wears glasses or contact lenses 0.6 0.7 0.7 0.8 0.8 0.8 -0.8
Ever taken oral contraceptive pill 0.9 0.9 1.9 -0.7 -0.8 -1.4 -0.9
Hearing aid user 0.9 1.0 2.0 -0.9 -1.4 1.0 -0.3
Mother’s age at death 0.4 0.5 0.8 0.2 0.9 -0.8 -0.8
Financial situation satisfaction 0.6 0.8 1.8 0.7 -0.8 0.4 -1.3
Tinnitus: Yes, now most or all of the time 2.9 3.4 6.2 -1.9 -2.5 0.6 -1.8
Commuting to job workplace: Public transport 0.2 0.2 0.5 -0.7 -0.3 -0.5 0.3
Eye problems/disorders: Glaucoma 2.3 2.7 4.5 -1.8 -0.6 -2.1 1.7
Medication: Blood pressure 1.3 2.4 5.1 -1.6 -2.3 1.2 -0.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.0 -1.1 -1.2 0.1 -1.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 3.1 1.0 -1.7 0.0 0.9
High cholesterol (Self-reported) 0.6 1.0 3.0 -0.1 -1.0 0.4 -1.7
Medication: Bendroflumethiazide 1.0 1.5 4.5 -0.5 -1.0 0.5 -2.1
Medication: Paracetamol 3.8 5.9 15.0 -0.4 -1.9 2.2 -3.9
Medication: Lisinopril 0.8 1.0 2.6 -0.5 -1.6 0.0 -1.1
Medication: Atorvastatin 0.3 0.4 0.9 0.2 -0.9 0.4 0.6
Illnesses of father: High blood pressure 1.3 1.6 4.3 0.2 0.3 1.4 -2.1
Alcohol drinker status: Never 0.3 0.3 1.1 -0.3 0.1 -1.1 0.2
Ever smoked 0.4 0.7 1.6 0.2 -0.5 1.2 -0.9
Basal metabolic rate 0.6 3.2 4.9 2.2 1.8 1.7 -1.3
Leg fat percentage (left) 0.2 0.8 2.6 -0.6 -1.6 0.2 -0.2
Arm fat-free mass (left) 0.4 2.0 2.9 1.5 1.1 1.3 -1.7
Number of operations (self-reported) 0.4 0.6 1.3 -0.2 -1.0 0.5 -1.1
Average weekly beer plus cider intake 0.8 1.1 4.3 -0.3 -2.1 -0.3 0.0
Irritability 0.7 1.2 2.9 1.3 -0.0 0.1 -1.7
Risk taking 0.5 0.7 1.2 0.8 1.1 -1.0 0.2
Ever had prostate specific antigen (PSA) test 2.2 2.6 6.1 1.9 0.6 2.5 -0.2
Fractured/broken bones in last 5 years 1.3 1.7 2.5 -1.0 -0.8 1.6 -1.6
Age started oral contraceptive pill 1.5 1.9 3.3 -1.1 -0.1 -1.7 1.8
Diastolic blood pressure, automated reading 0.7 2.1 5.9 -0.2 -1.0 2.4 -1.2
Ever depressed for a whole week 1.0 1.3 3.4 1.8 -0.3 0.3 -1.2
Unable to work because of sickness or disability 1.3 1.7 4.6 1.2 -0.4 0.8 -2.2
Commuting to job workplace: Cycle 0.4 0.5 1.4 1.2 -0.4 0.1 0.5
Myopia 0.7 1.0 2.3 0.5 0.8 1.5 -0.9
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.3 1.2 2.3 -1.4 0.8
Cholesterol lowering medication 0.4 0.6 1.9 -0.6 -1.4 0.0 0.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.0 -0.8 0.1 1.0 1.0
Pain experienced in last month 3.9 6.5 15.5 -1.6 1.1 -2.6 3.9
Supplements: Calcium 1.2 1.3 4.5 -0.2 -0.4 -0.8 2.1
Basal cell carcinoma (self-reported) 1.1 1.3 2.9 1.7 0.9 1.1 -0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 -0.6 -0.8 -0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.6 -0.3 -0.5 -1.3 0.4
Heart disease (siblings) 0.5 0.6 1.9 -0.4 0.5 1.4 -0.1
Alcohol drinker status: Previous 0.3 0.3 0.6 0.1 -0.8 -0.4 0.6
Pack years of smoking 0.6 0.8 2.4 -0.4 -0.8 1.6 -0.1
Impedance of whole body 0.3 1.5 5.0 -0.1 0.2 -1.0 2.2
Leg fat mass (left) 0.1 0.6 1.4 0.8 -0.3 1.2 -0.4
Arm predicted mass (left) 0.4 1.8 2.6 1.4 1.0 1.3 -1.6