TWAS hub - CCNF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0280	0.00200	0.000	0.024	0.021	0.026	0.009	0.36000	0.00052	0.00110	3e-04	0.02300
2	GTEx	Adrenal Gland	0.2955	0.0970	0.00280	-0.008	NA	-0.002	NA	-0.008	0.96000	NA	0.38000	NA	0.88000
3	TCGA	Breast Invasive Carcinoma	0.0505	0.0309	0.00048	0.002	0.005	0.006	NA	0.003	0.09400	0.03100	0.01600	NA	0.05700
4	TCGA	Prostate Adenocarcinoma	0.1032	0.0693	0.00022	0.026	0.035	0.035	NA	0.029	0.00091	0.00014	0.00015	NA	0.00049

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4
Knee pain experienced in last month	4.4	6.9	10.6	2.5	3.2	3.3
Ever unenthusiastic/disinterested for a whole week	3.6	4.4	8.3	-1.5	-2.9	-2.7
Migraine (self-reported)	3.6	4.5	11.5	-3.4	-1.9	-1.7
Triglycerides	3.3	5.5	18.3	1.9	0.0	4.3
Height	3.2	62.0	121.0	-6.6	-9.1	-11.0
Prospective memory result	3.2	3.9	8.0	-0.2	-2.8	-2.8
Standing height	3.2	31.9	66.7	-3.2	-7.1	-8.2
Comparative height size at age 10	3.2	17.8	37.7	-2.0	-5.5	-6.1
Asthma	3.0	5.9	9.6	3.0	2.3	3.1
Asthma (self-reported)	3.0	5.9	9.5	3.0	2.2	3.1
LDL Cholesterol	2.4	3.8	8.3	2.9	0.0	2.7
Depression (self-reported)	2.4	2.9	5.8	-2.4	-1.3	-2.0
Birth weight	2.4	5.2	10.3	0.4	-3.2	-3.2
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	8.8	-1.4	-3.0	-2.9
Breast Cancer	2.2	5.2	10.3	-3.2	-2.6	-1.9
Hair/balding pattern: Pattern 2	2.2	2.8	5.1	2.3	1.7	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	14.6	-0.3	-3.2	-3.8
Ever depressed for a whole week	2.0	2.5	5.4	-2.3	-1.5	-1.6
Noisy workplace	1.9	2.3	6.6	-2.6	-1.0	-1.2
Arm fat-free mass (right)	1.9	9.9	20.0	-2.5	-3.6	-4.5
Average weekly champagne plus white wine intake	1.9	2.6	6.0	2.5	1.4	1.5
Trunk fat-free mass	1.8	10.1	21.5	-1.9	-3.9	-4.6
Trunk predicted mass	1.8	10.5	22.5	-1.9	-4.0	-4.7
Exposure to tobacco smoke outside home	1.8	2.4	7.2	-0.1	1.5	2.7
Wheeze or whistling in the chest in last year	1.8	3.2	7.1	1.4	2.0	2.7
Arm predicted mass (right)	1.8	9.5	18.2	-2.7	-3.5	-4.3
Guilty feelings	1.8	2.7	6.0	-2.5	-1.4	-1.6
Illnesses of father: High blood pressure	1.8	2.3	5.0	-1.4	-1.5	-2.2
Crohns Disease (2017)	1.7	3.7	7.4	-2.2	-1.6	-2.7
Respiratory disease	1.7	3.7	6.2	2.5	1.7	2.3
Type 2 Diabetes (T2D) (2018)	1.7	3.2	6.7	0.2	2.5	2.6
Forced vital capacity (FVC)	1.7	6.6	14.4	-1.1	-3.3	-3.8
Number of live births	1.7	2.4	6.4	2.5	1.6	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.1	-1.8	-1.8	-2.0
Medication: Seretide 50 evohaler	1.7	2.0	3.7	1.7	1.2	1.9
Crohns Disease (2012)	1.6	2.6	8.2	-1.4	0.0	-2.9
Heel T-Score	1.6	13.1	31.1	1.8	4.2	5.6
Sitting height	1.6	11.3	22.2	-1.8	-4.5	-4.7
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	11.7	-0.6	-3.0	-3.4
Forced vital capacity (FVC), Best measure	1.6	5.7	12.5	-0.5	-3.2	-3.5
Arm fat-free mass (left)	1.6	8.1	17.6	-2.3	-3.1	-4.2
Arm predicted mass (left)	1.6	8.1	17.1	-2.3	-3.1	-4.1
Ovarian Cancer	1.5	1.9	3.3	1.8	1.6	1.3
Had major operations	1.5	1.8	5.5	-0.8	2.4	1.0
Whole body fat-free mass	1.5	8.3	18.4	-1.8	-3.4	-4.3
Whole body water mass	1.5	8.6	18.8	-1.9	-3.4	-4.3
Financial situation satisfaction	1.5	1.9	6.9	-2.6	0.7	0.4
Systolic Blood Pressure	1.4	7.1	12.3	-3.4	-2.1	-3.5
Frequency of depressed mood in last 2 weeks	1.4	1.9	6.7	-2.6	-0.9	-0.3
Arm fat percentage (right)	1.4	5.6	12.1	2.6	3.5	1.8
Birth weight of first child	1.4	2.5	4.8	-1.1	-2.0	-2.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.4	1.9	1.2	1.6
Arm fat percentage (left)	1.4	5.7	12.2	2.6	3.5	1.9
Neuroticism (Nagel 2018)	1.3	3.0	8.1	-2.8	-1.7	-1.1
Allergy	1.3	3.1	5.3	-1.9	-1.9	-2.3
Suffer from ‘nerves’	1.3	2.0	4.5	-2.1	1.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.3	0.7	1.8	1.5
Alcohol drinker status: Never	1.3	1.6	3.4	0.3	1.7	1.9
Basal cell carcinoma (self-reported)	1.3	1.5	3.8	0.3	-1.5	-2.0
Systolic blood pressure, automated reading	1.2	3.4	10.1	-3.2	-0.8	-1.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.5	-0.8	1.9	1.1
Number of incorrect matches in round	1.2	2.0	3.9	1.0	-2.0	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.3	-1.2	-1.3	-1.5
Heart disease (mother)	1.2	1.5	4.4	-0.3	-1.1	-2.1
Supplements: Vitamin C	1.2	1.4	3.9	2.0	-1.1	-0.6
Medication: Metformin	1.1	1.6	3.9	0.2	2.0	1.6
Worrier / anxious feelings	1.1	2.2	7.0	-2.6	-0.7	-1.1
Hair/balding pattern: Pattern 3	1.1	1.6	3.4	-1.9	-0.8	-1.5
Loud music exposure frequency	1.1	1.2	3.1	-1.8	-0.4	-1.3
Number of self-reported non-cancer illnesses	1.1	2.0	4.8	-0.1	2.2	1.8
Basal metabolic rate	1.1	6.2	15.0	-1.4	-2.8	-3.9
Age started oral contraceptive pill	1.1	1.4	2.8	-1.1	-1.7	-1.2
Ulcerative Colitis (UC)	1.0	1.9	4.1	0.0	2.0	1.8
Mean Putamen Volume	1.0	1.1	2.3	-1.4	0.0	-1.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	0.3	1.7	1.3
Leg fat percentage (left)	1.0	3.5	9.9	1.1	3.1	1.7
Depressed Affect (Nagel 2018)	0.9	1.9	4.2	-2.0	-1.5	-1.2
Neuroticism	0.9	2.1	6.6	-2.6	-1.1	-0.9
Leg fat-free mass (left)	0.9	4.8	11.8	-1.1	-2.5	-3.4
Leg predicted mass (left)	0.9	4.8	11.8	-1.2	-2.5	-3.4
Had menopause	0.9	1.1	2.4	-1.6	-1.1	-0.9
Pulse rate	0.9	1.5	2.6	1.1	1.6	1.4
Health satisfaction	0.9	1.2	2.8	-1.7	-1.0	-0.9
Family relationship satisfaction	0.9	1.1	2.2	-1.5	-1.2	-0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.2	0.6	1.8	0.8
Smoking status: Previous	0.9	1.3	2.6	-1.2	-1.6	-1.1
Average weekly red wine intake	0.9	1.3	3.0	-1.7	-0.7	-1.3
Diabetes diagnosed by doctor	0.9	1.4	2.8	0.7	1.7	1.5
Mineral and other dietary supplements	0.9	1.2	4.0	0.5	2.0	0.6
Pain experienced in last month	0.9	1.6	2.9	1.2	-1.7	-1.4
Depression (Nagel 2018)	0.8	1.3	4.3	-2.1	0.2	0.9
Reaction Time	0.8	1.5	3.2	0.3	-1.7	-1.8
Smoking Status	0.8	2.0	3.6	-1.9	-1.5	-1.4
Medication: Co-codamol	0.8	1.0	2.6	0.7	1.6	0.9
Mouth/teeth dental problems	0.8	1.2	2.1	1.2	-1.4	-1.2
Diabetes (self-reported)	0.8	1.2	2.2	0.7	1.5	1.4
Leg fat percentage (right)	0.8	3.0	8.1	1.3	2.9	1.4
Number of full brothers	0.8	1.0	2.2	1.5	0.7	1.0
Number of children fathered	0.8	0.9	2.6	0.3	1.6	0.9
Mean time to correctly identify matches	0.8	1.6	3.7	-0.7	-1.5	-1.9
Leg fat-free mass (right)	0.8	4.4	11.0	-1.3	-2.2	-3.3
Commuting to job workplace: Walk	0.8	0.9	1.9	1.4	-1.2	-0.3
Breast cancer (self-reported)	0.8	0.9	3.6	1.9	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.6	-0.1	-1.7	-1.9
Leg predicted mass (right)	0.8	4.2	10.4	-1.3	-2.2	-3.2
Eye problems/disorders: Glaucoma	0.8	0.9	2.4	-0.6	-1.5	-1.0
Number of operations (self-reported)	0.8	1.2	3.1	0.6	1.7	1.1
Commuting to job workplace: Cycle	0.8	1.0	2.7	-0.6	-1.6	-0.8
Cholesterol lowering medication	0.8	1.2	2.4	1.6	1.3	0.8
Major Depression (MDD)	0.7	0.8	3.2	0.0	0.0	-1.8
Chronotype (morning person)	0.7	1.6	4.5	-2.1	-1.1	-0.8
Average weekly spirits intake	0.7	0.9	3.5	-0.4	1.9	0.2
Sensitivity / hurt feelings	0.7	1.2	2.2	-1.1	-1.3	-1.5
Average weekly fortified wine intake	0.7	0.8	2.3	0.8	1.5	0.4
Nervous feelings	0.7	1.3	4.9	-2.2	-0.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	0.9	1.4	0.8
Fluid intelligence score	0.7	1.4	3.4	-0.2	1.9	1.4
Happiness	0.7	0.8	1.7	-0.9	-1.3	-0.9
Medication: Lansoprazole	0.7	0.7	2.6	0.4	1.6	0.4
Body fat percentage	0.7	2.9	7.9	1.6	2.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.2	-0.2	1.8	0.1
Chest pain or discomfort	0.7	1.0	2.5	0.2	1.3	1.6
Osteoarthritis (self-reported)	0.7	1.0	2.9	-0.1	1.7	1.0
Medication: Blood pressure	0.7	1.4	4.6	0.6	2.2	0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.1	-0.4	1.8	0.2
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.2	-0.2	-1.8	-0.8
Medication: Atorvastatin	0.7	0.9	1.6	1.2	1.0	0.9
Worry (Nagel 2018)	0.6	1.2	4.7	-2.2	-0.5	0.2
BMI	0.6	3.4	9.5	1.1	3.1	1.8
Hand grip strength (left)	0.6	1.5	3.2	-0.2	-1.8	-1.6
Diabetes (father)	0.6	0.7	1.4	-1.2	-0.9	-0.8
Body mass index (BMI)	0.6	2.5	6.5	1.2	2.5	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.9	-0.0	0.8	1.7
Time employed in main current job	0.6	0.7	1.2	-0.9	-1.1	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	-0.2	1.5	0.6
Glaucoma (self-reported)	0.6	0.7	1.7	0.0	-1.3	-1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	1.0	0.7	1.0
Comparative body size at age 10	0.6	1.5	3.2	-0.5	-1.6	-1.8
Worry too long after embarrassment	0.6	1.0	3.6	-1.9	0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.8	1.7	0.2	0.4
Medication for cholesterol	0.6	0.9	2.7	-0.6	-1.6	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.9	1.4	0.6	0.7
Diastolic blood pressure, automated reading	0.6	2.0	4.0	-2.0	-1.1	-1.7
Schizophrenia (2018)	0.5	1.0	4.0	0.2	0.0	-2.0
HbA1C	0.5	0.5	2.2	-0.1	0.0	1.5
Schizophrenia (2014)	0.5	1.1	3.2	-1.1	0.0	-1.8
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-0.4	-1.1	-1.4
High blood pressure (mother)	0.5	0.7	2.2	1.5	0.8	0.2
Neuroticism score	0.5	1.1	4.5	-2.1	0.3	-0.1
Lung cancer (father)	0.5	0.6	0.9	0.8	1.0	0.9
Illnesses of mother	0.5	0.6	2.2	-1.5	-0.4	0.0
Hair/balding pattern: Pattern 4	0.5	1.3	5.0	-2.2	0.1	0.1
Medication: Amlodipine	0.5	0.7	1.6	1.2	1.0	0.2
Shortness of breath walking on level ground	0.5	0.6	1.6	-1.3	0.6	0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	3.2	-0.1	-1.8	-0.7
Medication: Blood pressure	0.5	0.9	2.0	-1.4	1.2	0.3
Medication: Allopurinol	0.5	0.7	1.8	1.4	0.3	0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	1.4	0.4	0.7
Back pain experienced in last month	0.5	0.7	1.9	-0.4	1.4	0.8
Miserableness	0.5	0.9	3.3	-1.8	0.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	0.5	1.3	0.6
Alcohol drinker status: Previous	0.5	0.5	1.6	-0.3	1.3	0.7
HDL Cholesterol	0.4	0.7	2.6	-0.6	0.0	-1.6
Lupus	0.4	0.6	2.6	0.0	0.0	-1.6
Blood Platelet Count	0.4	4.3	13.0	3.6	1.5	1.4
Blood White Count	0.4	3.2	6.6	-0.1	-2.6	-2.5
Vitamin and mineral supplements	0.4	0.6	1.3	-1.0	1.2	-0.3
Trunk fat percentage	0.4	1.6	4.7	1.2	2.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	0.3	-0.7	-1.1
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-1.1	-0.9	-0.0
High blood pressure	0.4	1.1	2.4	-1.5	1.5	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.7	-1.3	0.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.4	0.7	1.2
Medication: Atenolol	0.4	0.6	1.9	-1.4	-0.1	-0.6
Medication: Ramipril	0.4	0.6	1.9	-0.3	0.5	1.4
Mouth/teeth dental problems: Dentures	0.4	0.8	2.3	0.2	1.5	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.8	0.8	0.8
Medication: Paracetamol	0.4	0.7	2.0	-0.8	-0.5	-1.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.3	-0.9	-0.9
Neck or shoulder pain in last month	0.4	0.6	1.6	-0.4	0.8	1.3
Medication: Omeprazole	0.4	0.4	1.5	-0.0	1.2	0.4
Leg pain on walking	0.4	0.5	1.8	-1.4	0.3	-0.1
Medication: Aspirin	0.4	0.5	1.4	-0.0	1.2	0.9
Mood swings	0.4	0.6	1.7	-1.3	-0.4	-0.9
Long-standing illness, disability or infirmity	0.4	0.7	1.7	0.2	1.0	1.3
Eye problems/disorders: Cataract	0.4	0.5	1.8	-1.4	0.0	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	-0.8	0.0	-1.0
Ever smoked	0.4	0.7	1.6	-0.5	-1.3	-0.9
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-1.1	-0.9	-0.0
Unable to work because of sickness or disability	0.4	0.6	2.1	-1.4	-0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.6	1.6	-1.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.8	1.4	0.2	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	-1.1	-0.2	-0.4
Alzheimer’s Disease (in father)	0.3	0.4	1.1	1.1	-0.4	-0.4
Fasting Glucose	0.3	0.4	0.8	0.2	0.9	0.8
Neuroticism (2016)	0.3	0.4	1.0	-0.3	0.6	1.0
Number of treatments/medications taken	0.3	0.5	1.3	-0.4	1.1	0.6
Ever had hysterectomy (womb removed)	0.3	0.3	1.1	-0.2	-0.2	-1.1
Angina	0.3	0.4	1.2	-1.1	0.6	0.3
Diabetes (mother)	0.3	0.3	1.2	1.1	-0.3	0.2
Severe depression (siblings)	0.3	0.4	0.6	-0.8	-0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-1.1	-0.1	0.8
Age when periods started (menarche)	0.3	0.6	2.1	-1.4	0.5	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	0.3	0.6
Supplements: Glucosamine	0.3	0.4	1.0	0.9	-1.0	-0.2
Past tobacco smoking	0.3	0.5	0.8	0.8	0.9	0.9
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-1.0	-0.5	-0.9
Heart attack	0.3	0.4	0.9	-1.0	0.6	0.7
Weight	0.3	1.6	5.7	-0.3	-0.7	-2.4
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-0.1	-0.9	-1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.4	-1.6	-0.2	-0.4
Arm fat mass (right)	0.3	1.1	2.7	1.4	1.6	-0.1
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.9	0.2	0.6
Tense / ‘highly strung’	0.3	0.5	2.0	-1.4	-0.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	-1.3	-0.5	0.1
Blood clot in the leg (DVT)	0.3	0.4	1.3	1.2	0.1	0.3
Headache pain in last month	0.3	0.6	1.6	-1.3	0.5	0.6
Qualifications: College or University degree	0.3	0.8	1.7	0.6	1.1	1.3
Eye problems/disorders: None of the above	0.3	0.3	0.9	0.9	0.4	0.5
Angina (self-reported)	0.3	0.4	1.0	-1.0	0.5	0.4
Number of full sisters	0.3	0.4	1.0	0.6	1.0	0.4
Overall health rating	0.3	0.6	1.4	-0.9	1.2	0.4
Age at last live birth	0.3	0.4	1.3	1.2	-0.4	0.3
Illnesses of father: Heart disease	0.3	0.5	1.4	0.3	1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.6	-0.7	0.8	0.8
Medication: Aspirin	0.3	0.4	1.2	0.0	1.1	0.7
Arm fat mass (left)	0.3	1.3	3.2	1.4	1.8	0.1
Wears glasses or contact lenses	0.3	0.3	0.6	0.5	-0.8	-0.7
Commuting to job workplace: Public transport	0.3	0.3	1.2	1.1	0.0	0.2
Average weekly beer plus cider intake	0.3	0.4	1.3	0.3	-1.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	0.6	0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	1.8	0.0	0.0	-1.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.9	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	-1.2	0.8	-0.0
Primary Biliary Cirrhosis	0.2	0.3	1.1	0.2	0.0	-1.1
Ulcerative Colitis	0.2	0.3	0.8	-0.9	0.0	0.6
Cardiovascular Disease	0.2	0.6	2.0	-1.4	0.4	-0.5
Lung FEV1/FVC ratio	0.2	1.1	3.6	0.1	-1.0	-1.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	0.6	0.6	0.6
Supplements: Zinc	0.2	0.2	0.9	-0.0	-1.0	0.1
Hand grip strength (right)	0.2	0.6	1.2	-0.5	-1.1	-1.0
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.4	0.9	-0.6
Maternal smoking around birth	0.2	0.3	1.1	-0.3	1.0	0.3
Multivitamins +/- minerals	0.2	0.2	0.7	-0.4	-0.8	0.3
Alcohol usually taken with meals	0.2	0.4	1.0	-0.4	-0.5	-1.0
Financial difficulties in last 2 years	0.2	0.2	0.5	-0.7	-0.5	0.2
Pain all over the body in last month	0.2	0.2	0.5	0.4	0.3	0.7
Impedance of arm (right)	0.2	1.1	3.2	1.8	0.9	0.4
Hip circumference	0.2	0.8	2.5	-0.5	0.7	-1.6
Medication: Cholesterol lowering	0.2	0.3	0.5	0.5	0.7	0.6
Impedance of arm (left)	0.2	1.1	3.1	1.8	0.9	0.5
Length of working week for main job	0.2	0.2	0.5	0.7	-0.2	0.5
Breastfed as a baby	0.2	0.2	0.6	-0.8	-0.3	-0.3
Pulse wave reflection index	0.2	0.2	0.7	-0.5	-0.8	-0.1
Gout (self-reported)	0.2	0.2	0.6	0.1	0.5	0.8
High blood pressure (siblings)	0.2	0.2	0.5	0.5	0.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	1.0	0.2	0.4
Pulse wave peak to peak time	0.2	0.2	0.7	-0.5	0.0	-0.8
Emphysema/chronic bronchitis	0.2	0.3	0.7	0.8	0.4	0.5
Pulse rate, automated reading	0.2	0.6	1.3	1.1	0.8	0.8
Hypertension (Self-reported)	0.2	0.6	1.6	-1.3	0.9	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.4	-0.8	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.3	0.7	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.9	0.1	-0.1
Osteoporosis (self-reported)	0.2	0.3	0.6	0.6	-0.8	0.2
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.1	-0.3	0.8
Hearing aid user	0.2	0.3	0.9	-0.1	-0.4	-0.9
Medication: Paracetamol	0.2	0.4	1.4	-1.2	0.3	-0.3
Supplements: Calcium	0.2	0.3	0.6	0.5	0.4	0.8
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.0	0.0	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.1	0.7	0.4
Age at First Birth	0.1	0.2	0.8	-0.1	-0.3	0.9
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.0	0.0	0.5
Rheumatoid Arthritis	0.1	0.2	0.5	0.5	0.0	0.7
Blood Red Count	0.1	0.5	0.9	0.5	0.9	1.0
Hypothyroidism (self reported)	0.1	0.1	0.5	-0.0	-0.7	-0.1
Relative age of first facial hair	0.1	0.2	0.5	0.7	-0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.3	-0.7	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.2	0.4
Pack years adult smoking proportion	0.1	0.1	0.3	0.2	-0.6	-0.0
Current tobacco smoking	0.1	0.1	0.3	-0.5	0.1	-0.3
Fed-up feelings	0.1	0.1	0.4	-0.4	0.6	0.1
Relative age voice broke	0.1	0.1	0.3	-0.0	-0.1	-0.6
Taking other prescription medications	0.1	0.2	0.4	-0.2	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-1.0	0.0	0.3
Trunk fat mass	0.1	0.5	1.0	0.5	0.9	-1.0
Waist circumference	0.1	0.4	0.9	0.4	0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.8	-0.9	-0.2	0.1
Medication: Simvastatin	0.1	0.1	0.2	-0.4	-0.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	-0.0	0.7
Falls in the last year	0.1	0.1	0.2	0.5	0.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.5	0.2	0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.3	-0.4	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.7	-0.0	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	0.6	-0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.4	0.1	-0.6
Age at first live birth	0.1	0.3	0.7	0.3	-0.8	0.5
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	-0.0	0.1
Whole body fat mass	0.1	0.5	1.3	0.7	1.1	-0.6
Leg fat mass (right)	0.1	0.4	1.4	0.5	1.2	-0.3
Alcohol intake frequency.	0.1	0.2	0.6	-0.8	0.5	0.4
Loneliness, isolation	0.1	0.1	0.3	-0.5	0.2	0.2
Friendships satisfaction	0.1	0.2	0.4	-0.2	-0.6	-0.4
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.2	0.2	0.6
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.0	-0.1	0.6
Mother’s age at death	0.1	0.1	0.2	0.4	-0.1	0.4
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	0.5	0.0
Irritability	0.1	0.2	0.6	-0.8	0.1	0.2
Risk taking	0.1	0.1	0.3	0.5	0.4	0.1
Myopia	0.1	0.1	0.3	-0.1	0.3	0.5
Pack years of smoking	0.1	0.1	0.5	-0.1	-0.7	-0.2
Leg fat mass (left)	0.1	0.4	1.4	0.3	1.2	-0.4
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.2	0.0	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	-0.3	0.3	-0.0
Prostate Cancer	0.0	0.0	0.1	0.2	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.0	0.0	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.1	0.2	0.5	0.2	-0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.3	-0.3	-0.3
Allergy or Eczema	0.0	0.1	0.2	0.1	0.3	0.4
Lung FVC	0.0	0.0	0.1	0.2	-0.0	0.3
Hair Pigment	0.0	1.4	4.5	2.1	0.7	0.7
Tanning	0.0	0.6	1.1	-0.6	1.1	1.0
Impedance of leg (right)	0.0	0.1	0.2	0.2	-0.5	-0.3
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.4	0.2	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.2	0.4	0.4
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.0	-0.5	-0.0
Impedance of leg (left)	0.0	0.0	0.0	-0.2	0.0	0.0
Had other major operations	0.0	0.0	0.1	0.0	-0.3	-0.1
Qualifications: None of the above	0.0	0.1	0.1	-0.4	-0.2	-0.2
Illnesses of siblings	0.0	0.1	0.2	0.2	-0.1	-0.5
Father’s age at death	0.0	0.1	0.2	-0.2	0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.1	-0.4	0.2
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	0.3	-0.2
Medication: Gliclazide	0.0	0.0	0.1	0.0	0.4	0.2
Smoking status: Current	0.0	0.0	0.0	-0.1	0.2	-0.2
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.1	0.2	-0.3
Medication: Lisinopril	0.0	0.1	0.1	-0.3	0.2	-0.2
Heart disease (siblings)	0.0	0.0	0.1	-0.1	0.0	0.3
Impedance of whole body	0.0	0.1	0.2	0.5	0.1	-0.1

Hub : Genes

CCNF

Models

Trait associations