Hub : Genes

CD180

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0756 0.0279 0.00150 0.032 0.005 0.021 0.024 0.035 1.2e-05 4.6e-02 3.8e-04 0.00013 4.3e-06
2 ROSMAP Brain Pre-frontal Cortex 0.0520 0.0220 0.00270 0.054 0.003 0.038 0.011 0.037 1.5e-07 1.2e-01 1.1e-05 0.01200 1.2e-05
3 TCGA Brain Lower Grade Glioma 0.0623 0.0273 0.00051 0.006 0.039 0.018 NA 0.009 6.6e-02 2.8e-05 3.1e-03 NA 2.7e-02
4 TCGA Lung Adenocarcinoma 0.0627 0.0297 0.00160 0.047 0.034 0.047 NA 0.048 3.5e-06 6.3e-05 3.4e-06 NA 2.7e-06
5 TCGA Pancreatic Adenocarcinoma 0.1130 0.0550 0.00530 0.006 0.026 0.000 NA 0.006 1.7e-01 2.8e-02 3.2e-01 NA 1.8e-01
6 TCGA Testicular Germ Cell Tumors 0.1740 0.0720 0.00180 0.106 0.050 0.022 NA 0.064 1.4e-04 7.5e-03 5.7e-02 NA 2.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.6 2.5 6.3 -1.2 -2.5 -1.8 1.9 -0.5 0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 2.1 0.5 -1.3 -0.3 1.5 0.7 0.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.7 0.1 0.5 -0.4 -0.2 1.3 0.5
Depression (Nagel 2018) 0.2 0.3 0.8 -0.2 0.6 -0.0 -0.9 0.3 -0.5
Intelligence (Savage-Jansen 2018) 4.3 13.1 27.9 -0.3 -4.8 -2.9 4.3 -0.8 5.3
Neuroticism (Nagel 2018) 0.3 0.8 2.2 0.2 0.8 0.0 -0.4 1.5 -1.4
Schizophrenia (2018) 0.5 0.9 2.3 1.5 0.3 1.1 0.3 1.4 -0.1
Schizophrenia vs Biploar Disorder 1.2 1.6 3.0 1.7 1.6 1.3 -0.3 1.5 -0.3
Worry (Nagel 2018) 0.3 0.5 2.5 0.1 -0.4 -0.6 0.5 -0.1 -1.6
Alzheimer’s Disease (in mother) 1.4 1.6 4.1 0.3 -1.0 -1.5 1.4 0.6 2.0
Alzheimer’s Disease (in father) 1.6 1.7 6.3 1.8 -0.2 0.6 0.7 2.5 -0.0
Alzheimer’s Disease (including proxy) 1.3 1.9 3.9 1.4 -1.0 -1.1 1.4 2.0 1.0
Crohns Disease (2017) 0.2 0.5 1.2 -0.2 0.6 0.9 -1.1 0.5 -0.4
Irritable Bowel Disease (IBD) 0.7 1.7 3.3 0.1 1.8 1.4 -1.8 0.7 -1.1
Ulcerative Colitis (UC) 0.7 1.4 3.4 1.0 1.8 0.8 -1.2 0.8 -1.1
Major Depression (MDD) 1.1 1.3 4.0 0.1 -0.8 -2.0 0.4 -1.7 -0.2
Reaction Time 0.3 0.5 1.9 0.4 0.6 -0.5 -0.4 1.4 0.4
Verbal and Numeric Reasoning (VNR) 3.6 8.6 21.2 -1.1 -3.5 -2.5 3.2 -0.5 4.6
Breast Cancer 1.3 3.1 6.8 0.9 -1.5 -2.6 1.2 2.0 1.8
Ovarian Cancer 2.2 2.9 6.1 -0.6 -0.9 -2.2 1.0 2.1 2.5
Prostate Cancer 1.9 2.7 5.4 1.7 -2.2 -0.8 2.3 0.3 1.4
Age at First Birth 0.9 1.4 3.2 -1.8 -1.3 1.0 0.1 -1.4 0.5
Bipolar Disorder (2011) 2.8 2.8 10.2 0.0 -3.2 -2.2 0.0 0.0 1.2
Body Mass Index (BMI) (2010) 1.2 1.6 3.2 1.8 1.1 0.5 0.2 1.7 -1.4
Coronary Artery Disease (CAD) 0.4 0.5 0.9 -0.7 -0.9 0.4 -0.2 -0.9 0.9
Crohns Disease (2012) 0.5 0.8 1.7 0.7 1.1 1.3 -1.1 0.4 -0.2
Mean Putamen Volume 0.5 0.6 1.2 0.2 1.1 0.9 -0.9 0.6 -0.6
Fasting Glucose 0.8 0.9 3.1 -1.2 -0.1 -0.3 -0.7 -1.8 -0.6
HbA1C 0.4 0.4 0.8 -0.5 0.5 0.9 -0.8 -0.7 0.3
HDL Cholesterol 0.4 0.6 1.3 0.3 0.5 1.1 -1.2 -0.1 -0.9
LDL Cholesterol 1.7 2.7 11.8 0.2 -1.2 -1.1 1.2 0.7 3.4
Lupus 0.7 1.1 3.3 0.2 0.8 -1.1 -1.1 0.3 -1.8
Neuroticism (2016) 0.1 0.1 0.2 0.3 0.2 -0.0 0.1 0.3 -0.5
Primary Biliary Cirrhosis 0.9 1.3 3.6 1.7 1.0 0.4 0.0 1.9 -0.2
Rheumatoid Arthritis 0.3 0.4 1.3 0.6 -0.0 -1.2 0.3 0.7 0.3
Schizophrenia (2014) 0.2 0.5 1.5 0.3 0.4 1.2 -0.4 0.3 -0.9
Triglycerides 0.1 0.2 0.6 0.3 0.8 -0.1 -0.1 0.2 0.7
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.8 0.0 1.7 0.7 -0.9 0.0 -0.9
Ulcerative Colitis 0.8 1.1 1.9 0.1 1.1 1.4 -1.2 -0.4 -1.3
Blood Eosinophil Count 0.4 3.4 11.2 0.1 2.5 0.4 -1.7 -0.3 -3.3
Blood Platelet Count 0.5 5.5 11.6 1.3 3.4 2.2 -2.0 1.1 -3.1
Blood Red Count 0.2 1.9 5.1 0.4 1.4 -0.4 -0.1 2.3 2.0
Blood White Count 0.1 1.0 3.0 0.5 1.4 -0.3 -0.8 1.7 -0.6
Heel T-Score 0.1 0.9 2.0 0.1 1.2 0.5 -1.2 -0.7 -1.4
BMI 0.7 4.0 7.8 0.9 2.8 2.0 -1.4 2.7 -1.3
Height 0.1 1.0 2.8 0.4 -0.9 1.7 0.7 0.2 1.4
Waist Hip Ratio (WHR) 0.7 3.3 10.5 1.3 3.2 1.1 -1.5 1.8 0.7
Systolic Blood Pressure 0.3 1.6 3.3 1.0 -1.8 -0.2 1.3 -0.3 1.8
Smoking Status 0.4 1.0 3.2 1.3 0.9 0.6 -0.4 -0.1 -1.8
Allergy or Eczema 0.4 1.1 2.4 1.3 -0.6 -0.3 1.5 1.3 0.9
Cardiovascular Disease 0.4 1.4 4.2 1.8 0.8 0.4 -0.2 2.1 0.2
Hypothyroidism (self reported) 0.1 0.3 0.9 0.5 -0.1 -0.2 0.3 -0.6 1.0
Respiratory disease 0.9 2.0 7.5 2.7 0.5 -0.5 0.6 1.7 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 0.4 1.1 1.1 -0.6 0.1 -0.5
Lung FEV1/FVC ratio 0.3 1.3 3.3 -0.1 -1.4 0.9 1.4 -1.8 0.3
Lung FVC 0.3 1.6 2.9 -1.0 -1.7 -1.3 1.5 -1.3 0.3
Neuroticism 0.1 0.3 1.0 -0.5 0.3 0.0 -0.2 1.0 -0.6
Chronotype (morning person) 1.6 3.8 7.1 -2.7 1.4 0.2 -2.4 -1.9 -2.0
Hair Pigment 0.1 1.6 4.4 0.8 -2.1 -1.3 0.9 1.4 0.4
Tanning 0.2 2.1 4.8 0.6 2.2 1.1 -1.7 0.0 -1.8
Hand grip strength (left) 0.6 1.6 5.2 0.4 2.3 0.9 -1.6 0.5 -0.9
Number of treatments/medications taken 1.1 2.0 6.6 2.2 0.1 0.6 0.3 2.6 -0.6
Average weekly spirits intake 0.2 0.3 1.4 -1.2 0.1 -0.5 0.1 0.2 -0.4
Sensitivity / hurt feelings 0.6 1.0 3.4 -1.2 0.4 0.7 -0.7 1.8 0.1
Frequency of depressed mood in last 2 weeks 1.4 1.9 4.4 -0.5 1.8 0.5 -2.1 1.4 -1.1
Hearing difficulty/problems: Yes 0.4 0.6 1.5 0.1 -0.7 -0.2 1.0 1.2 0.6
Relative age of first facial hair 0.5 1.1 2.4 0.6 -1.1 -0.8 1.3 0.1 1.6
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.7 1.2 -0.9 -0.4 1.5 0.9 1.6
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.4 1.1 -0.3 -1.2 0.4 -0.0 -0.8
Ever had hysterectomy (womb removed) 1.5 1.7 7.9 2.8 0.3 0.3 0.4 1.4 -0.4
Systolic blood pressure, automated reading 0.7 1.9 3.7 0.8 -1.9 -1.3 1.8 0.3 1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.9 -0.0 -0.7 -0.7 1.0 0.1 1.4
Angina 0.2 0.3 0.9 0.9 -0.5 0.1 0.1 -0.1 0.9
Medication for hormone replacement therapy 1.3 1.4 2.7 -0.4 -1.6 -1.6 1.5 0.4 0.9
Vitamin and mineral supplements 1.9 2.6 6.1 0.8 2.5 2.2 -1.7 0.4 -1.1
Supplements: Zinc 0.6 0.7 2.4 -0.2 -0.3 0.8 -0.2 0.8 1.5
Medication: Co-codamol 2.1 2.5 5.6 1.7 -1.7 -0.9 2.4 1.5 0.8
Medication: Metformin 0.1 0.2 0.8 0.5 0.1 0.1 0.2 0.9 0.3
Diabetes (father) 1.8 2.2 4.2 2.1 1.8 1.6 -1.0 1.5 -0.0
Diabetes (mother) 0.6 0.7 3.1 0.7 0.3 0.1 0.9 1.8 0.2
Severe depression (siblings) 1.3 1.5 5.7 0.2 -1.1 -2.4 1.4 0.2 -0.1
Pack years adult smoking proportion 0.3 0.4 1.2 -0.1 0.4 -1.1 -0.1 1.1 0.1
Impedance of leg (right) 0.4 1.8 4.4 0.4 -1.1 -2.1 0.8 -0.7 2.0
Leg fat-free mass (left) 0.5 2.5 5.5 0.7 1.7 2.3 -0.5 2.4 -0.8
Trunk fat percentage 0.5 1.8 9.4 0.7 0.1 0.5 0.0 3.1 0.9
Hand grip strength (right) 1.1 3.0 6.6 -0.7 2.6 1.4 -2.5 -0.1 -1.6
Townsend deprivation index at recruitment 1.2 1.7 4.0 1.6 1.1 1.4 -0.3 2.0 0.7
Current tobacco smoking 0.6 1.0 3.9 2.0 0.1 0.4 1.0 1.0 0.4
Average weekly fortified wine intake 1.5 1.7 4.6 0.1 -2.2 -0.9 1.6 0.1 1.4
Maternal smoking around birth 1.0 1.4 4.6 0.8 -0.1 -1.7 0.4 2.1 0.4
Fed-up feelings 0.3 0.6 1.3 -0.6 0.8 0.3 -1.1 0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.8 -0.6 0.7 0.3 -1.4 0.9 0.4
Relative age voice broke 0.6 1.0 3.1 -0.2 -1.4 -0.1 0.7 0.1 1.8
Taking other prescription medications 1.8 2.8 8.4 2.6 -0.2 0.1 1.2 2.9 0.6
Age when periods started (menarche) 0.6 1.5 7.0 -1.0 -0.5 -2.6 0.6 -0.7 0.1
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 -1.2 0.7 0.4 -1.6 -0.1 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.8 -0.3 0.4 0.7 -0.5 -0.7 -1.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 0.8 0.1 0.9 -0.3 1.1 -0.1
Qualifications: CSEs or equivalent 1.0 1.4 3.5 -0.0 1.9 1.0 -1.2 1.3 -0.8
Serious illness, injury or assault to yourself 2.4 3.0 9.7 3.1 -0.7 -0.3 1.6 1.7 1.5
High blood pressure 0.8 2.3 7.2 1.8 -0.1 -0.2 0.5 2.7 1.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 1.2 0.6 1.2 0.3 0.4 0.1
Multivitamins +/- minerals 1.6 2.1 4.5 0.2 -2.1 -1.9 2.1 -0.0 0.3
Stomach or abdominal pain in last month 1.1 1.4 5.2 -0.0 -0.6 -2.3 0.9 1.0 1.0
Supplements: Glucosamine 0.9 1.1 2.4 -0.5 -1.4 -1.1 1.5 0.1 1.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 2.1 0.7 0.8 0.9 -0.7 0.9 1.5
Medication: Atenolol 2.2 2.8 4.9 1.3 2.2 2.2 -1.5 0.9 -1.5
Medication: Levothyroxine sodium 0.9 1.5 3.1 1.4 -0.8 -0.2 1.5 1.1 1.7
Sitting height 0.2 1.3 3.7 -0.3 -1.9 0.4 1.6 0.2 1.2
Chronic bronchitis/emphysema (father) 1.9 2.2 6.3 2.5 0.8 -0.5 0.1 2.5 -0.0
High blood pressure (mother) 0.3 0.4 0.8 -0.0 0.2 0.6 -0.8 -0.9 0.6
Body mass index (BMI) 0.5 1.9 6.3 0.2 1.4 0.9 -1.1 2.5 -1.1
Impedance of leg (left) 0.5 2.6 6.1 0.8 -1.4 -2.3 1.1 -0.4 2.5
Leg predicted mass (left) 0.5 2.6 5.5 0.7 1.8 2.4 -0.6 2.3 -0.9
Trunk fat mass 0.5 2.3 11.6 0.9 0.6 0.9 -0.1 3.4 0.6
Waist circumference 0.9 3.3 9.7 1.1 2.0 1.9 -1.1 3.1 -0.3
Number of incorrect matches in round 0.4 0.6 2.2 -0.2 0.6 0.5 -0.5 0.7 -1.5
Past tobacco smoking 0.2 0.4 0.9 -0.6 0.6 0.8 -0.3 -0.0 0.9
Alcohol usually taken with meals 0.6 1.0 3.0 -0.0 -1.7 0.5 1.2 -0.1 1.2
Nervous feelings 0.2 0.4 1.5 -0.5 0.1 -0.3 -0.6 0.7 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.5 0.6 1.0 0.7 -0.9 1.2 -0.1
Hearing difficulty/problems with background noise 0.4 0.6 2.2 -1.5 -0.6 -0.2 0.1 -0.9 0.2
Hair/balding pattern: Pattern 2 1.0 1.3 2.4 -1.4 -1.5 -0.8 0.5 -1.1 1.3
Had menopause 1.4 1.7 5.1 -0.1 -2.3 -1.7 1.1 -1.1 -0.3
Had other major operations 1.1 1.4 4.3 2.1 0.0 -0.4 1.1 1.6 0.2
Forced vital capacity (FVC) 0.0 0.2 0.5 -0.0 -0.2 -0.7 0.6 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 1.7 -0.6 0.1 0.4 -0.5 -1.0 -1.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.5 1.6 0.6 0.1 0.3 1.0 -0.4
Qualifications: None of the above 1.1 2.3 4.4 0.2 1.8 1.7 -1.7 0.4 -2.1
Financial difficulties in last 2 years 1.1 1.5 2.7 1.2 1.5 1.6 -0.8 1.4 -0.5
Mouth/teeth dental problems 0.7 1.0 3.7 -1.9 -0.6 0.1 0.3 -1.4 -0.1
Heart attack 1.3 1.6 4.0 2.0 -0.7 0.0 1.5 1.1 1.3
Allergy 0.5 1.1 3.8 -2.0 -0.6 0.4 -0.7 -1.1 -0.8
Pain all over the body in last month 0.3 0.4 0.8 0.4 -0.2 -0.9 0.3 0.8 -0.5
Diabetes (self-reported) 0.1 0.1 0.2 -0.0 -0.5 -0.2 0.3 0.3 0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.2 0.4 0.0 -0.2 0.4 1.5 1.3
Medication: Ramipril 0.3 0.4 1.7 0.9 -0.1 1.3 -0.3 -0.1 0.2
Medication: Simvastatin 0.8 1.2 3.0 1.0 0.5 1.7 -0.6 0.7 -1.4
Fluid intelligence score 3.4 7.0 16.9 -1.1 -3.2 -2.3 2.8 0.1 4.1
Illnesses of siblings 2.8 3.9 7.4 -2.7 1.5 1.7 -2.4 -0.3 -2.3
Neuroticism score 0.1 0.2 1.0 -0.4 -0.0 -0.0 -0.2 1.0 0.1
Weight 0.5 2.3 9.5 0.7 1.3 1.4 -0.4 3.1 -0.2
Impedance of arm (right) 0.8 3.7 8.8 0.3 -2.3 -2.0 1.9 -0.8 3.0
Arm fat percentage (right) 0.3 1.1 6.5 -0.1 -0.1 -0.2 -0.0 2.5 0.5
Trunk fat-free mass 0.3 1.5 3.6 0.3 1.5 1.9 -0.5 1.0 -1.3
Hip circumference 0.3 1.4 6.6 0.4 0.3 1.3 -0.1 2.6 -0.0
Time employed in main current job 1.8 2.1 4.7 -2.2 -1.9 0.1 -0.2 -2.0 -0.4
Alcohol intake versus 10 years previously 0.2 0.3 1.3 -0.4 -0.0 -0.5 1.1 -0.5 0.1
Father’s age at death 0.7 1.0 2.6 0.6 -1.3 0.1 1.6 -0.9 0.7
Worrier / anxious feelings 0.4 0.8 2.1 1.4 0.6 0.9 0.3 1.1 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 0.4 0.2 0.2 0.2 0.4 0.6
Falls in the last year 0.8 1.0 2.1 0.3 1.0 1.3 -1.5 0.9 -0.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.9 0.9 0.1 -0.1 0.3 -0.0 0.2
Number of live births 2.0 2.9 7.5 -1.5 -0.4 -1.9 -1.2 -2.7 -1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.5 -0.3 -0.2 0.0 0.5 -0.7 0.3
Pulse rate 0.3 0.5 1.6 -0.2 -0.5 -0.3 -0.5 1.0 1.3
Happiness 0.9 1.0 3.0 -1.7 0.6 0.3 -1.3 -0.9 -0.4
Noisy workplace 0.5 0.6 1.4 0.1 1.2 0.2 -1.0 0.2 -1.2
Qualifications: A levels/AS levels or equivalent 1.8 4.0 6.4 -1.7 -2.5 -1.8 1.3 -2.3 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.9 -0.1 -0.3 -0.3 0.2 -0.5 1.0
Mouth/teeth dental problems: Dentures 0.8 1.4 4.1 2.0 -0.3 -1.4 1.1 1.0 -0.6
Asthma 0.5 0.9 2.0 1.4 0.2 -0.8 0.4 1.2 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.9 -0.4 1.4 1.1 -0.8 1.1 -0.3
Medication: Cholesterol lowering 0.8 1.2 4.6 2.1 0.1 0.5 0.2 1.0 -1.1
Depression (self-reported) 1.0 1.2 4.5 0.6 1.2 0.5 -0.9 2.1 -0.3
Medication: Lansoprazole 1.9 2.2 4.4 0.2 2.1 1.6 -1.9 0.7 -1.6
Prospective memory result 2.7 3.3 11.2 -0.7 1.3 1.1 -2.1 -1.1 -3.3
Lung cancer (father) 2.9 3.4 9.0 -0.1 3.0 1.0 -2.6 -0.0 -1.9
Illnesses of mother 0.5 0.6 1.2 -1.1 0.8 -0.1 -1.0 0.4 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.8 -0.4 -0.8 -0.9 1.3 -0.5 0.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 0.3 0.1 -0.1 -0.6 -0.4 -0.1
Impedance of arm (left) 0.8 3.7 8.9 -0.2 -2.5 -1.6 2.1 -0.6 3.0
Arm fat mass (right) 0.3 1.4 7.6 0.4 0.4 0.7 -0.1 2.8 -0.0
Trunk predicted mass 0.3 1.5 3.7 0.3 1.5 1.9 -0.5 1.0 -1.4
Standing height 0.1 1.5 2.7 1.2 -0.1 1.5 1.1 1.1 1.6
Length of working week for main job 3.5 3.8 9.7 -1.4 1.6 1.8 -3.1 -2.0 -1.1
Exposure to tobacco smoke at home 0.6 0.6 3.3 1.8 0.5 -0.3 -0.1 0.0 0.5
Breastfed as a baby 0.3 0.4 1.0 -0.4 -0.4 0.0 -0.9 -0.4 1.0
Tense / ‘highly strung’ 0.4 0.6 2.3 -0.7 0.4 -0.3 -0.4 1.5 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 4.1 0.2 -0.1 -0.9 0.6 2.0 0.2
Hair/balding pattern: Pattern 4 0.4 0.9 4.1 1.0 0.5 -0.4 -0.2 -0.2 -2.0
Birth weight of first child 1.2 2.2 6.8 -0.0 1.7 2.6 -1.4 -0.3 -1.3
Peak expiratory flow (PEF) 0.0 0.0 0.1 0.1 0.0 0.1 0.3 0.0 0.3
Pulse wave reflection index 0.3 0.3 1.3 0.6 -0.2 -0.2 0.0 -1.1 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.5 0.3 0.5 -0.4 0.2 0.0
Loud music exposure frequency 0.3 0.3 1.1 -0.7 -0.2 -1.1 0.1 0.2 -0.1
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 4.0 -1.0 -2.0 -1.7 1.9 -0.5 1.6
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 5.3 0.6 2.3 0.2 -1.6 1.0 0.5
Blood clot in the leg (DVT) 0.4 0.5 1.8 1.4 0.9 0.3 0.2 -0.3 0.5
Medication: Paracetamol 0.3 0.5 0.9 -0.9 0.6 0.9 -0.9 0.1 -0.5
Headache pain in last month 0.5 0.8 1.8 -0.5 1.2 1.1 -1.3 0.2 0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 5.0 -2.2 0.1 0.2 -1.2 -1.2 0.6
Glaucoma (self-reported) 0.6 0.8 2.5 1.6 0.5 0.4 0.2 1.2 0.4
Gout (self-reported) 0.1 0.1 0.3 0.0 0.4 0.4 -0.3 0.3 -0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 0.2 -0.4 -0.5 0.5 0.0 0.7
Medication: Amlodipine 0.4 0.6 1.4 -0.4 0.6 1.2 -0.8 -0.7 -0.7
Medication: Ventolin 100micrograms inhaler 2.5 3.2 12.3 3.5 -0.4 -0.1 1.8 1.6 0.8
Birth weight 0.5 1.2 3.1 1.0 -1.2 -0.4 1.8 0.7 0.8
Chronic bronchitis/emphysema (mother) 3.4 4.0 8.9 2.0 -1.4 -0.3 3.0 1.7 2.4
High blood pressure (siblings) 2.0 2.9 5.6 2.2 -1.2 -1.4 1.9 0.4 2.4
Forced vital capacity (FVC), Best measure 0.1 0.4 0.9 0.3 -0.1 -0.8 1.0 0.6 0.8
Body fat percentage 0.4 1.7 9.2 0.4 -0.1 0.1 -0.1 3.0 1.0
Leg fat percentage (right) 0.4 1.3 7.1 0.1 0.3 -0.5 -0.5 2.7 0.4
Arm fat-free mass (right) 0.4 2.2 4.4 0.6 1.6 2.0 -0.7 2.1 -1.1
Exposure to tobacco smoke outside home 2.1 2.7 5.9 1.3 1.5 2.4 -0.9 1.9 -1.4
Comparative body size at age 10 0.4 1.1 6.1 -0.3 0.0 0.3 -0.2 -0.6 -2.5
Number of full brothers 0.4 0.5 1.4 -0.3 -0.7 -0.6 1.2 -0.0 0.8
Worry too long after embarrassment 0.5 0.8 1.5 -0.8 0.8 1.2 -1.0 -0.4 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.9 0.3 -0.8 -1.7 1.1 1.5 0.9
Wheeze or whistling in the chest in last year 0.8 1.4 3.8 1.9 -0.8 -0.1 1.5 0.8 1.1
Number of children fathered 1.7 2.0 3.6 -1.7 1.2 0.1 -1.9 -0.3 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 -0.0 -0.2 -0.7 -0.2 -0.2 -0.7
Age at first live birth 0.2 0.4 0.7 0.2 -0.8 0.6 0.8 -0.2 0.8
Pulse wave peak to peak time 0.2 0.2 0.7 -0.2 -0.3 -0.1 0.9 0.5 0.4
Health satisfaction 0.3 0.4 1.0 0.9 -0.1 0.4 0.3 1.0 0.8
Shortness of breath walking on level ground 1.2 1.4 3.4 1.8 -0.4 -0.5 1.0 1.9 0.5
Qualifications: College or University degree 0.8 2.6 4.1 -1.5 -2.0 -0.9 1.1 -1.9 2.0
Eye problems/disorders: None of the above 0.5 0.6 1.9 -0.7 -1.1 0.0 0.4 -1.4 -0.2
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.5 0.3 -0.4 0.1 0.7 -0.2 -0.2
Emphysema/chronic bronchitis 1.7 1.9 5.6 2.4 -0.1 0.3 0.8 1.7 1.4
Medication for pain relief, constipation, heartburn 1.3 2.2 6.0 -1.4 -1.5 -1.6 0.8 -2.4 0.4
Neck or shoulder pain in last month 0.6 0.8 2.1 1.1 1.2 0.2 -0.3 1.5 -0.2
Medication: Blood pressure 0.7 1.2 4.0 2.0 0.2 -0.2 0.9 1.4 -0.6
Angina (self-reported) 0.2 0.3 0.9 0.6 -0.7 -0.2 0.1 -0.2 0.9
Migraine (self-reported) 0.4 0.5 1.0 -0.6 0.4 1.0 -0.9 -0.6 0.5
Medication: Ibuprofen 0.6 0.7 1.8 -0.1 1.3 0.5 -0.3 1.3 -0.3
Medication: Allopurinol 0.2 0.3 0.4 0.5 -0.5 -0.6 0.6 0.6 -0.2
Medication: Omeprazole 1.5 1.8 5.5 1.7 1.3 -0.6 0.3 2.3 -0.8
Medication: Seretide 50 evohaler 0.3 0.4 0.9 0.6 -0.8 -0.9 0.4 -0.5 0.3
Mean time to correctly identify matches 0.3 0.5 1.8 0.9 0.3 -0.3 -0.2 1.4 0.2
Heart disease (mother) 0.5 0.6 1.3 0.3 -1.2 0.1 0.7 1.1 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.6 -0.7 -0.2 0.7 -0.5 -1.3 0.2
Whole body fat mass 0.6 2.3 12.0 0.9 0.5 0.7 -0.1 3.5 0.6
Leg fat mass (right) 0.6 2.2 10.8 0.6 1.0 0.5 -0.6 3.3 -0.1
Arm predicted mass (right) 0.4 2.2 4.2 0.5 1.7 2.1 -1.0 1.8 -1.1
Pulse rate, automated reading 0.1 0.3 1.4 0.2 -0.3 0.1 -0.1 1.2 -0.0
Alcohol intake frequency. 0.1 0.2 0.3 -0.6 0.2 0.1 -0.3 -0.3 -0.5
Comparative height size at age 10 0.2 1.3 2.9 1.3 -0.1 1.7 0.8 1.0 1.2
Number of full sisters 1.2 1.4 6.7 2.6 0.4 0.0 1.1 0.4 0.7
Suffer from ‘nerves’ 0.2 0.2 0.8 0.0 0.5 0.0 -0.4 0.5 -0.9
Overall health rating 1.1 2.4 4.8 2.2 1.3 1.4 -1.1 2.2 -0.1
Chest pain or discomfort 2.1 3.0 7.9 2.8 0.0 0.7 0.7 2.0 2.3
Had major operations 2.7 3.1 5.5 1.2 -1.7 -1.7 2.4 1.2 2.1
Age at last live birth 0.2 0.3 0.7 0.0 -0.4 -0.1 -0.0 -0.8 0.8
Family relationship satisfaction 0.1 0.1 0.3 -0.3 0.2 -0.5 -0.2 0.6 0.1
Leg pain on walking 1.2 1.5 4.3 0.5 1.2 0.7 -1.4 0.4 -2.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 3.1 -1.4 1.8 -0.2 -1.3 0.2 -1.1
Commuting to job workplace: Car/motor vehicle 1.1 1.2 3.8 -2.0 0.8 -1.1 -0.9 0.0 -1.0
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 8.1 -2.9 -0.5 -1.1 -0.8 -2.1 -1.2
Medication: Aspirin 1.6 2.2 7.2 2.7 -0.7 0.6 0.8 1.9 1.0
Supplements: Vitamin C 0.6 0.8 2.4 -0.7 0.5 0.9 -1.5 -0.7 -0.1
Knee pain experienced in last month 1.9 2.9 7.3 2.3 1.5 1.4 -0.0 2.7 -0.7
Hypertension (Self-reported) 1.0 2.7 8.4 2.3 0.1 -0.2 0.4 2.9 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.8 1.4 0.3 1.0 -0.2 -1.1 -0.8 -1.2
Illnesses of father: Heart disease 0.9 1.2 2.8 1.2 -0.9 -0.7 1.7 1.4 -0.1
Illnesses of siblings: Diabetes 0.8 0.9 3.5 1.9 0.4 -0.0 1.2 0.2 0.8
Smoking status: Previous 0.3 0.4 2.1 0.6 0.1 -0.1 -0.3 -0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 -0.0 0.4 0.7 -0.0 0.7 0.5
Whole body fat-free mass 0.4 2.1 5.0 0.6 1.7 2.2 -0.6 1.7 -1.1
Leg fat-free mass (right) 0.5 2.8 6.6 0.9 1.7 2.6 -0.5 2.4 -0.7
Arm fat percentage (left) 0.3 1.4 8.0 -0.2 0.1 0.2 -0.1 2.8 0.5
Average weekly red wine intake 0.7 1.1 2.3 1.5 -0.8 -1.2 0.4 0.7 1.2
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.5 -0.0 -0.3 1.0 0.1 -1.0
Mood swings 0.7 1.3 5.7 0.1 1.2 -0.1 -0.7 2.4 0.4
Loneliness, isolation 0.9 1.2 2.2 -1.0 1.4 0.3 -1.5 1.5 -0.0
Long-standing illness, disability or infirmity 1.6 2.4 9.2 3.0 0.7 0.7 0.7 1.9 0.6
Ever had bowel cancer screening 0.5 0.6 1.0 0.9 0.7 -1.0 0.2 0.6 -0.8
Diabetes diagnosed by doctor 0.1 0.2 0.6 0.8 0.2 0.2 0.1 0.8 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.8 0.3 -0.5 0.5 0.0 1.3 1.3
Friendships satisfaction 1.5 1.8 7.1 -2.7 -0.7 -0.6 -0.4 -1.7 -0.1
Qualifications: nursing, teaching 2.1 3.3 7.6 -2.6 -2.8 -1.4 1.2 -1.0 1.1
Commuting to job workplace: Walk 0.6 0.6 1.6 0.8 -1.3 -0.1 0.8 -0.1 0.8
Eye problems/disorders: Cataract 1.0 1.1 2.8 -0.4 -0.9 -1.7 1.3 1.0 0.6
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.4 -0.1 0.3 -0.3 0.4 -0.1
Medication for cholesterol 0.3 0.5 1.4 -0.4 0.3 -0.6 0.1 -1.2 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 6.5 1.2 1.3 1.8 -0.6 2.5 -0.1
Back pain experienced in last month 0.3 0.5 1.4 1.2 0.8 0.6 0.3 0.5 -0.4
Mineral and other dietary supplements 1.1 1.5 5.7 0.5 1.3 2.4 -1.0 0.8 0.1
Breast cancer (self-reported) 0.4 0.5 2.1 -0.4 -0.2 -0.2 -0.0 -0.9 -1.5
Asthma (self-reported) 0.7 1.3 3.0 1.7 -0.1 -1.0 0.7 1.2 1.3
Osteoporosis (self-reported) 0.4 0.5 1.2 0.1 -0.7 -1.0 -0.2 -1.1 -0.5
Osteoarthritis (self-reported) 0.4 0.5 1.9 0.7 0.4 0.3 -0.3 1.4 -0.4
Medication: Aspirin 1.8 2.4 6.2 2.5 -0.8 0.1 1.2 2.0 1.3
Medication: Gliclazide 0.8 0.9 3.0 -1.0 0.7 0.8 -1.7 0.0 -0.2
Illnesses of father: None of the above (group 1) 1.7 2.1 4.2 -1.9 1.5 0.9 -2.0 -1.2 -0.1
Smoking status: Current 0.3 0.5 2.0 1.4 0.0 0.5 0.7 0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 -0.3 0.3 0.2 -0.1 0.3 -0.3
Whole body water mass 0.3 2.0 4.9 0.6 1.5 2.2 -0.5 1.6 -1.1
Leg predicted mass (right) 0.5 2.7 6.4 0.8 1.6 2.5 -0.5 2.4 -0.7
Arm fat mass (left) 0.4 1.6 8.2 0.3 0.6 0.8 -0.3 2.9 -0.1
Number of self-reported non-cancer illnesses 1.7 2.9 7.8 2.4 -0.4 0.2 0.7 2.8 1.8
Average weekly champagne plus white wine intake 0.5 0.7 2.5 -0.5 0.2 0.6 -0.5 -1.0 -1.6
Miserableness 0.6 1.1 3.2 0.0 -0.4 -0.5 0.7 1.6 1.8
Guilty feelings 0.5 0.7 2.6 0.8 0.5 0.3 0.5 1.6 -0.4
Wears glasses or contact lenses 1.6 1.9 4.8 -1.6 -2.2 -0.8 1.6 -0.7 -0.3
Ever taken oral contraceptive pill 0.6 0.7 1.4 -0.8 1.1 -0.6 -1.2 -0.4 -0.6
Hearing aid user 0.5 0.5 2.1 -0.5 -0.6 -0.2 0.5 -0.2 1.4
Mother’s age at death 0.2 0.3 0.7 -0.8 -0.4 0.1 -0.3 -0.8 0.2
Financial situation satisfaction 0.8 1.0 2.8 0.7 1.0 0.6 -1.7 1.1 -0.5
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.7 0.1 -1.3 -1.9 0.7 -0.9 1.6
Commuting to job workplace: Public transport 0.9 1.1 4.1 2.0 -0.2 1.1 0.5 -0.2 0.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.0 -0.0 0.1 -0.1 0.3 0.5
Medication: Blood pressure 0.5 0.9 1.5 0.8 0.1 1.0 -0.9 1.2 1.2
Pain type(s) experienced in last month: Hip pain 1.4 1.7 6.1 2.5 0.1 -0.1 1.1 1.6 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.2 -0.0 -0.6 -1.8 0.5 -0.9 -0.6
High cholesterol (Self-reported) 0.9 1.5 5.9 0.5 0.7 1.3 -0.8 0.0 -2.4
Medication: Bendroflumethiazide 0.4 0.6 2.1 -0.7 0.1 -0.6 -1.5 0.7 0.6
Medication: Paracetamol 0.2 0.4 0.8 -0.7 0.7 0.9 -0.4 0.3 -0.3
Medication: Lisinopril 1.0 1.3 2.8 1.7 0.7 1.0 0.1 1.5 1.1
Medication: Atorvastatin 3.7 4.5 7.3 2.1 -2.0 -2.5 2.7 1.2 2.0
Illnesses of father: High blood pressure 0.4 0.5 2.2 -0.2 -0.6 -0.2 0.4 -1.5 -0.1
Alcohol drinker status: Never 0.4 0.4 1.2 -0.4 0.3 0.6 -0.5 -1.1 -0.7
Ever smoked 0.3 0.6 1.1 1.1 -0.8 -0.6 1.0 0.5 -0.1
Basal metabolic rate 0.4 2.2 4.6 0.6 1.6 2.1 -0.6 2.1 -0.9
Leg fat percentage (left) 0.4 1.5 7.7 0.3 0.3 -0.6 -0.5 2.8 0.6
Arm fat-free mass (left) 0.3 1.4 2.9 0.7 1.3 1.5 -0.5 1.7 -0.8
Number of operations (self-reported) 0.6 1.0 5.0 2.2 0.4 0.0 0.4 0.6 -0.1
Average weekly beer plus cider intake 1.6 2.4 6.6 0.6 2.6 0.8 -2.0 0.9 -1.2
Irritability 0.3 0.5 1.2 -1.1 0.5 -0.1 -0.5 1.0 -0.3
Risk taking 0.8 1.2 3.0 1.5 0.2 -0.4 0.1 1.7 1.3
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.5 1.1 -1.3 0.3 1.6 -0.8 -0.2
Fractured/broken bones in last 5 years 0.3 0.4 1.2 -0.5 0.6 -0.0 -1.1 0.1 -0.9
Age started oral contraceptive pill 1.3 1.7 4.4 -2.1 -1.1 -0.8 -0.5 -1.8 -0.1
Diastolic blood pressure, automated reading 0.2 0.6 1.8 1.1 -0.0 0.1 -0.1 1.3 0.8
Ever depressed for a whole week 0.4 0.5 1.2 1.1 0.2 0.8 0.3 0.7 0.6
Unable to work because of sickness or disability 1.2 1.6 3.6 1.2 1.2 0.8 -0.8 1.9 -1.2
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.2 0.6 0.6 -0.8 0.3 0.4
Myopia 0.9 1.3 3.6 -0.4 -1.2 -1.4 0.5 -1.9 0.7
Vascular/heart problems diagnosed by doctor 0.6 1.8 4.1 -1.7 0.3 0.0 -0.3 -2.0 -1.9
Cholesterol lowering medication 0.5 0.7 2.6 0.5 0.0 1.6 -0.4 -0.2 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 4.4 2.1 0.9 -0.5 0.6 1.6 -0.6
Pain experienced in last month 1.1 1.8 3.9 -2.0 -1.7 -0.4 0.4 -1.8 0.7
Supplements: Calcium 0.6 0.6 1.6 -0.2 -0.8 -1.2 0.9 -0.1 0.9
Basal cell carcinoma (self-reported) 0.3 0.3 0.9 -0.5 0.1 -0.9 0.1 -0.9 -0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 4.3 2.1 -0.6 0.1 1.5 1.3 1.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.2 1.5 0.6 0.2 0.6 0.1 1.0
Heart disease (siblings) 1.3 1.6 6.0 2.4 -0.4 -1.1 1.1 0.0 1.0
Alcohol drinker status: Previous 0.6 0.7 1.7 -1.1 0.4 -0.5 -0.9 -0.4 -1.3
Pack years of smoking 0.3 0.5 1.6 -0.2 0.6 -0.8 -0.5 1.2 -0.1
Impedance of whole body 0.6 3.0 8.8 0.4 -1.9 -1.7 1.5 -0.4 3.0
Leg fat mass (left) 0.6 2.4 11.9 0.8 1.1 0.5 -0.6 3.5 -0.0
Arm predicted mass (left) 0.3 1.6 2.9 0.7 1.4 1.6 -0.7 1.7 -1.0