Hub : Genes

CD180

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0756	0.0279	0.00150	0.032	0.005	0.021	0.024	0.035	1.2e-05	4.6e-02	3.8e-04	0.00013	4.3e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.0520	0.0220	0.00270	0.054	0.003	0.038	0.011	0.037	1.5e-07	1.2e-01	1.1e-05	0.01200	1.2e-05
3	TCGA	Brain Lower Grade Glioma	0.0623	0.0273	0.00051	0.006	0.039	0.018	NA	0.009	6.6e-02	2.8e-05	3.1e-03	NA	2.7e-02
4	TCGA	Lung Adenocarcinoma	0.0627	0.0297	0.00160	0.047	0.034	0.047	NA	0.048	3.5e-06	6.3e-05	3.4e-06	NA	2.7e-06
5	TCGA	Pancreatic Adenocarcinoma	0.1130	0.0550	0.00530	0.006	0.026	0.000	NA	0.006	1.7e-01	2.8e-02	3.2e-01	NA	1.8e-01
6	TCGA	Testicular Germ Cell Tumors	0.1740	0.0720	0.00180	0.106	0.050	0.022	NA	0.064	1.4e-04	7.5e-03	5.7e-02	NA	2.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.6	2.5	6.3	-1.2	-2.5	-1.8	1.9	-0.5	0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	2.1	0.5	-1.3	-0.3	1.5	0.7	0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.7	0.1	0.5	-0.4	-0.2	1.3	0.5
Depression (Nagel 2018)	0.2	0.3	0.8	-0.2	0.6	-0.0	-0.9	0.3	-0.5
Intelligence (Savage-Jansen 2018)	4.3	13.1	27.9	-0.3	-4.8	-2.9	4.3	-0.8	5.3
Neuroticism (Nagel 2018)	0.3	0.8	2.2	0.2	0.8	0.0	-0.4	1.5	-1.4
Schizophrenia (2018)	0.5	0.9	2.3	1.5	0.3	1.1	0.3	1.4	-0.1
Schizophrenia vs Biploar Disorder	1.2	1.6	3.0	1.7	1.6	1.3	-0.3	1.5	-0.3
Worry (Nagel 2018)	0.3	0.5	2.5	0.1	-0.4	-0.6	0.5	-0.1	-1.6
Alzheimer’s Disease (in mother)	1.4	1.6	4.1	0.3	-1.0	-1.5	1.4	0.6	2.0
Alzheimer’s Disease (in father)	1.6	1.7	6.3	1.8	-0.2	0.6	0.7	2.5	-0.0
Alzheimer’s Disease (including proxy)	1.3	1.9	3.9	1.4	-1.0	-1.1	1.4	2.0	1.0
Crohns Disease (2017)	0.2	0.5	1.2	-0.2	0.6	0.9	-1.1	0.5	-0.4
Irritable Bowel Disease (IBD)	0.7	1.7	3.3	0.1	1.8	1.4	-1.8	0.7	-1.1
Ulcerative Colitis (UC)	0.7	1.4	3.4	1.0	1.8	0.8	-1.2	0.8	-1.1
Major Depression (MDD)	1.1	1.3	4.0	0.1	-0.8	-2.0	0.4	-1.7	-0.2
Reaction Time	0.3	0.5	1.9	0.4	0.6	-0.5	-0.4	1.4	0.4
Verbal and Numeric Reasoning (VNR)	3.6	8.6	21.2	-1.1	-3.5	-2.5	3.2	-0.5	4.6
Breast Cancer	1.3	3.1	6.8	0.9	-1.5	-2.6	1.2	2.0	1.8
Ovarian Cancer	2.2	2.9	6.1	-0.6	-0.9	-2.2	1.0	2.1	2.5
Prostate Cancer	1.9	2.7	5.4	1.7	-2.2	-0.8	2.3	0.3	1.4
Age at First Birth	0.9	1.4	3.2	-1.8	-1.3	1.0	0.1	-1.4	0.5
Bipolar Disorder (2011)	2.8	2.8	10.2	0.0	-3.2	-2.2	0.0	0.0	1.2
Body Mass Index (BMI) (2010)	1.2	1.6	3.2	1.8	1.1	0.5	0.2	1.7	-1.4
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.7	-0.9	0.4	-0.2	-0.9	0.9
Crohns Disease (2012)	0.5	0.8	1.7	0.7	1.1	1.3	-1.1	0.4	-0.2
Mean Putamen Volume	0.5	0.6	1.2	0.2	1.1	0.9	-0.9	0.6	-0.6
Fasting Glucose	0.8	0.9	3.1	-1.2	-0.1	-0.3	-0.7	-1.8	-0.6
HbA1C	0.4	0.4	0.8	-0.5	0.5	0.9	-0.8	-0.7	0.3
HDL Cholesterol	0.4	0.6	1.3	0.3	0.5	1.1	-1.2	-0.1	-0.9
LDL Cholesterol	1.7	2.7	11.8	0.2	-1.2	-1.1	1.2	0.7	3.4
Lupus	0.7	1.1	3.3	0.2	0.8	-1.1	-1.1	0.3	-1.8
Neuroticism (2016)	0.1	0.1	0.2	0.3	0.2	-0.0	0.1	0.3	-0.5
Primary Biliary Cirrhosis	0.9	1.3	3.6	1.7	1.0	0.4	0.0	1.9	-0.2
Rheumatoid Arthritis	0.3	0.4	1.3	0.6	-0.0	-1.2	0.3	0.7	0.3
Schizophrenia (2014)	0.2	0.5	1.5	0.3	0.4	1.2	-0.4	0.3	-0.9
Triglycerides	0.1	0.2	0.6	0.3	0.8	-0.1	-0.1	0.2	0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.8	0.0	1.7	0.7	-0.9	0.0	-0.9
Ulcerative Colitis	0.8	1.1	1.9	0.1	1.1	1.4	-1.2	-0.4	-1.3
Blood Eosinophil Count	0.4	3.4	11.2	0.1	2.5	0.4	-1.7	-0.3	-3.3
Blood Platelet Count	0.5	5.5	11.6	1.3	3.4	2.2	-2.0	1.1	-3.1
Blood Red Count	0.2	1.9	5.1	0.4	1.4	-0.4	-0.1	2.3	2.0
Blood White Count	0.1	1.0	3.0	0.5	1.4	-0.3	-0.8	1.7	-0.6
Heel T-Score	0.1	0.9	2.0	0.1	1.2	0.5	-1.2	-0.7	-1.4
BMI	0.7	4.0	7.8	0.9	2.8	2.0	-1.4	2.7	-1.3
Height	0.1	1.0	2.8	0.4	-0.9	1.7	0.7	0.2	1.4
Waist Hip Ratio (WHR)	0.7	3.3	10.5	1.3	3.2	1.1	-1.5	1.8	0.7
Systolic Blood Pressure	0.3	1.6	3.3	1.0	-1.8	-0.2	1.3	-0.3	1.8
Smoking Status	0.4	1.0	3.2	1.3	0.9	0.6	-0.4	-0.1	-1.8
Allergy or Eczema	0.4	1.1	2.4	1.3	-0.6	-0.3	1.5	1.3	0.9
Cardiovascular Disease	0.4	1.4	4.2	1.8	0.8	0.4	-0.2	2.1	0.2
Hypothyroidism (self reported)	0.1	0.3	0.9	0.5	-0.1	-0.2	0.3	-0.6	1.0
Respiratory disease	0.9	2.0	7.5	2.7	0.5	-0.5	0.6	1.7	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	0.4	1.1	1.1	-0.6	0.1	-0.5
Lung FEV1/FVC ratio	0.3	1.3	3.3	-0.1	-1.4	0.9	1.4	-1.8	0.3
Lung FVC	0.3	1.6	2.9	-1.0	-1.7	-1.3	1.5	-1.3	0.3
Neuroticism	0.1	0.3	1.0	-0.5	0.3	0.0	-0.2	1.0	-0.6
Chronotype (morning person)	1.6	3.8	7.1	-2.7	1.4	0.2	-2.4	-1.9	-2.0
Hair Pigment	0.1	1.6	4.4	0.8	-2.1	-1.3	0.9	1.4	0.4
Tanning	0.2	2.1	4.8	0.6	2.2	1.1	-1.7	0.0	-1.8
Hand grip strength (left)	0.6	1.6	5.2	0.4	2.3	0.9	-1.6	0.5	-0.9
Number of treatments/medications taken	1.1	2.0	6.6	2.2	0.1	0.6	0.3	2.6	-0.6
Average weekly spirits intake	0.2	0.3	1.4	-1.2	0.1	-0.5	0.1	0.2	-0.4
Sensitivity / hurt feelings	0.6	1.0	3.4	-1.2	0.4	0.7	-0.7	1.8	0.1
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.4	-0.5	1.8	0.5	-2.1	1.4	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.5	0.1	-0.7	-0.2	1.0	1.2	0.6
Relative age of first facial hair	0.5	1.1	2.4	0.6	-1.1	-0.8	1.3	0.1	1.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.7	1.2	-0.9	-0.4	1.5	0.9	1.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	1.1	-0.3	-1.2	0.4	-0.0	-0.8
Ever had hysterectomy (womb removed)	1.5	1.7	7.9	2.8	0.3	0.3	0.4	1.4	-0.4
Systolic blood pressure, automated reading	0.7	1.9	3.7	0.8	-1.9	-1.3	1.8	0.3	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	-0.0	-0.7	-0.7	1.0	0.1	1.4
Angina	0.2	0.3	0.9	0.9	-0.5	0.1	0.1	-0.1	0.9
Medication for hormone replacement therapy	1.3	1.4	2.7	-0.4	-1.6	-1.6	1.5	0.4	0.9
Vitamin and mineral supplements	1.9	2.6	6.1	0.8	2.5	2.2	-1.7	0.4	-1.1
Supplements: Zinc	0.6	0.7	2.4	-0.2	-0.3	0.8	-0.2	0.8	1.5
Medication: Co-codamol	2.1	2.5	5.6	1.7	-1.7	-0.9	2.4	1.5	0.8
Medication: Metformin	0.1	0.2	0.8	0.5	0.1	0.1	0.2	0.9	0.3
Diabetes (father)	1.8	2.2	4.2	2.1	1.8	1.6	-1.0	1.5	-0.0
Diabetes (mother)	0.6	0.7	3.1	0.7	0.3	0.1	0.9	1.8	0.2
Severe depression (siblings)	1.3	1.5	5.7	0.2	-1.1	-2.4	1.4	0.2	-0.1
Pack years adult smoking proportion	0.3	0.4	1.2	-0.1	0.4	-1.1	-0.1	1.1	0.1
Impedance of leg (right)	0.4	1.8	4.4	0.4	-1.1	-2.1	0.8	-0.7	2.0
Leg fat-free mass (left)	0.5	2.5	5.5	0.7	1.7	2.3	-0.5	2.4	-0.8
Trunk fat percentage	0.5	1.8	9.4	0.7	0.1	0.5	0.0	3.1	0.9
Hand grip strength (right)	1.1	3.0	6.6	-0.7	2.6	1.4	-2.5	-0.1	-1.6
Townsend deprivation index at recruitment	1.2	1.7	4.0	1.6	1.1	1.4	-0.3	2.0	0.7
Current tobacco smoking	0.6	1.0	3.9	2.0	0.1	0.4	1.0	1.0	0.4
Average weekly fortified wine intake	1.5	1.7	4.6	0.1	-2.2	-0.9	1.6	0.1	1.4
Maternal smoking around birth	1.0	1.4	4.6	0.8	-0.1	-1.7	0.4	2.1	0.4
Fed-up feelings	0.3	0.6	1.3	-0.6	0.8	0.3	-1.1	0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.8	-0.6	0.7	0.3	-1.4	0.9	0.4
Relative age voice broke	0.6	1.0	3.1	-0.2	-1.4	-0.1	0.7	0.1	1.8
Taking other prescription medications	1.8	2.8	8.4	2.6	-0.2	0.1	1.2	2.9	0.6
Age when periods started (menarche)	0.6	1.5	7.0	-1.0	-0.5	-2.6	0.6	-0.7	0.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	-1.2	0.7	0.4	-1.6	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.8	-0.3	0.4	0.7	-0.5	-0.7	-1.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	0.8	0.1	0.9	-0.3	1.1	-0.1
Qualifications: CSEs or equivalent	1.0	1.4	3.5	-0.0	1.9	1.0	-1.2	1.3	-0.8
Serious illness, injury or assault to yourself	2.4	3.0	9.7	3.1	-0.7	-0.3	1.6	1.7	1.5
High blood pressure	0.8	2.3	7.2	1.8	-0.1	-0.2	0.5	2.7	1.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	1.2	0.6	1.2	0.3	0.4	0.1
Multivitamins +/- minerals	1.6	2.1	4.5	0.2	-2.1	-1.9	2.1	-0.0	0.3
Stomach or abdominal pain in last month	1.1	1.4	5.2	-0.0	-0.6	-2.3	0.9	1.0	1.0
Supplements: Glucosamine	0.9	1.1	2.4	-0.5	-1.4	-1.1	1.5	0.1	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.1	0.7	0.8	0.9	-0.7	0.9	1.5
Medication: Atenolol	2.2	2.8	4.9	1.3	2.2	2.2	-1.5	0.9	-1.5
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.4	-0.8	-0.2	1.5	1.1	1.7
Sitting height	0.2	1.3	3.7	-0.3	-1.9	0.4	1.6	0.2	1.2
Chronic bronchitis/emphysema (father)	1.9	2.2	6.3	2.5	0.8	-0.5	0.1	2.5	-0.0
High blood pressure (mother)	0.3	0.4	0.8	-0.0	0.2	0.6	-0.8	-0.9	0.6
Body mass index (BMI)	0.5	1.9	6.3	0.2	1.4	0.9	-1.1	2.5	-1.1
Impedance of leg (left)	0.5	2.6	6.1	0.8	-1.4	-2.3	1.1	-0.4	2.5
Leg predicted mass (left)	0.5	2.6	5.5	0.7	1.8	2.4	-0.6	2.3	-0.9
Trunk fat mass	0.5	2.3	11.6	0.9	0.6	0.9	-0.1	3.4	0.6
Waist circumference	0.9	3.3	9.7	1.1	2.0	1.9	-1.1	3.1	-0.3
Number of incorrect matches in round	0.4	0.6	2.2	-0.2	0.6	0.5	-0.5	0.7	-1.5
Past tobacco smoking	0.2	0.4	0.9	-0.6	0.6	0.8	-0.3	-0.0	0.9
Alcohol usually taken with meals	0.6	1.0	3.0	-0.0	-1.7	0.5	1.2	-0.1	1.2
Nervous feelings	0.2	0.4	1.5	-0.5	0.1	-0.3	-0.6	0.7	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	0.6	1.0	0.7	-0.9	1.2	-0.1
Hearing difficulty/problems with background noise	0.4	0.6	2.2	-1.5	-0.6	-0.2	0.1	-0.9	0.2
Hair/balding pattern: Pattern 2	1.0	1.3	2.4	-1.4	-1.5	-0.8	0.5	-1.1	1.3
Had menopause	1.4	1.7	5.1	-0.1	-2.3	-1.7	1.1	-1.1	-0.3
Had other major operations	1.1	1.4	4.3	2.1	0.0	-0.4	1.1	1.6	0.2
Forced vital capacity (FVC)	0.0	0.2	0.5	-0.0	-0.2	-0.7	0.6	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.7	-0.6	0.1	0.4	-0.5	-1.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.5	1.6	0.6	0.1	0.3	1.0	-0.4
Qualifications: None of the above	1.1	2.3	4.4	0.2	1.8	1.7	-1.7	0.4	-2.1
Financial difficulties in last 2 years	1.1	1.5	2.7	1.2	1.5	1.6	-0.8	1.4	-0.5
Mouth/teeth dental problems	0.7	1.0	3.7	-1.9	-0.6	0.1	0.3	-1.4	-0.1
Heart attack	1.3	1.6	4.0	2.0	-0.7	0.0	1.5	1.1	1.3
Allergy	0.5	1.1	3.8	-2.0	-0.6	0.4	-0.7	-1.1	-0.8
Pain all over the body in last month	0.3	0.4	0.8	0.4	-0.2	-0.9	0.3	0.8	-0.5
Diabetes (self-reported)	0.1	0.1	0.2	-0.0	-0.5	-0.2	0.3	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.2	0.4	0.0	-0.2	0.4	1.5	1.3
Medication: Ramipril	0.3	0.4	1.7	0.9	-0.1	1.3	-0.3	-0.1	0.2
Medication: Simvastatin	0.8	1.2	3.0	1.0	0.5	1.7	-0.6	0.7	-1.4
Fluid intelligence score	3.4	7.0	16.9	-1.1	-3.2	-2.3	2.8	0.1	4.1
Illnesses of siblings	2.8	3.9	7.4	-2.7	1.5	1.7	-2.4	-0.3	-2.3
Neuroticism score	0.1	0.2	1.0	-0.4	-0.0	-0.0	-0.2	1.0	0.1
Weight	0.5	2.3	9.5	0.7	1.3	1.4	-0.4	3.1	-0.2
Impedance of arm (right)	0.8	3.7	8.8	0.3	-2.3	-2.0	1.9	-0.8	3.0
Arm fat percentage (right)	0.3	1.1	6.5	-0.1	-0.1	-0.2	-0.0	2.5	0.5
Trunk fat-free mass	0.3	1.5	3.6	0.3	1.5	1.9	-0.5	1.0	-1.3
Hip circumference	0.3	1.4	6.6	0.4	0.3	1.3	-0.1	2.6	-0.0
Time employed in main current job	1.8	2.1	4.7	-2.2	-1.9	0.1	-0.2	-2.0	-0.4
Alcohol intake versus 10 years previously	0.2	0.3	1.3	-0.4	-0.0	-0.5	1.1	-0.5	0.1
Father’s age at death	0.7	1.0	2.6	0.6	-1.3	0.1	1.6	-0.9	0.7
Worrier / anxious feelings	0.4	0.8	2.1	1.4	0.6	0.9	0.3	1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.4	0.2	0.2	0.2	0.4	0.6
Falls in the last year	0.8	1.0	2.1	0.3	1.0	1.3	-1.5	0.9	-0.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.9	0.9	0.1	-0.1	0.3	-0.0	0.2
Number of live births	2.0	2.9	7.5	-1.5	-0.4	-1.9	-1.2	-2.7	-1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	-0.3	-0.2	0.0	0.5	-0.7	0.3
Pulse rate	0.3	0.5	1.6	-0.2	-0.5	-0.3	-0.5	1.0	1.3
Happiness	0.9	1.0	3.0	-1.7	0.6	0.3	-1.3	-0.9	-0.4
Noisy workplace	0.5	0.6	1.4	0.1	1.2	0.2	-1.0	0.2	-1.2
Qualifications: A levels/AS levels or equivalent	1.8	4.0	6.4	-1.7	-2.5	-1.8	1.3	-2.3	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	-0.1	-0.3	-0.3	0.2	-0.5	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	4.1	2.0	-0.3	-1.4	1.1	1.0	-0.6
Asthma	0.5	0.9	2.0	1.4	0.2	-0.8	0.4	1.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.9	-0.4	1.4	1.1	-0.8	1.1	-0.3
Medication: Cholesterol lowering	0.8	1.2	4.6	2.1	0.1	0.5	0.2	1.0	-1.1
Depression (self-reported)	1.0	1.2	4.5	0.6	1.2	0.5	-0.9	2.1	-0.3
Medication: Lansoprazole	1.9	2.2	4.4	0.2	2.1	1.6	-1.9	0.7	-1.6
Prospective memory result	2.7	3.3	11.2	-0.7	1.3	1.1	-2.1	-1.1	-3.3
Lung cancer (father)	2.9	3.4	9.0	-0.1	3.0	1.0	-2.6	-0.0	-1.9
Illnesses of mother	0.5	0.6	1.2	-1.1	0.8	-0.1	-1.0	0.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	-0.4	-0.8	-0.9	1.3	-0.5	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.3	0.1	-0.1	-0.6	-0.4	-0.1
Impedance of arm (left)	0.8	3.7	8.9	-0.2	-2.5	-1.6	2.1	-0.6	3.0
Arm fat mass (right)	0.3	1.4	7.6	0.4	0.4	0.7	-0.1	2.8	-0.0
Trunk predicted mass	0.3	1.5	3.7	0.3	1.5	1.9	-0.5	1.0	-1.4
Standing height	0.1	1.5	2.7	1.2	-0.1	1.5	1.1	1.1	1.6
Length of working week for main job	3.5	3.8	9.7	-1.4	1.6	1.8	-3.1	-2.0	-1.1
Exposure to tobacco smoke at home	0.6	0.6	3.3	1.8	0.5	-0.3	-0.1	0.0	0.5
Breastfed as a baby	0.3	0.4	1.0	-0.4	-0.4	0.0	-0.9	-0.4	1.0
Tense / ‘highly strung’	0.4	0.6	2.3	-0.7	0.4	-0.3	-0.4	1.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.1	0.2	-0.1	-0.9	0.6	2.0	0.2
Hair/balding pattern: Pattern 4	0.4	0.9	4.1	1.0	0.5	-0.4	-0.2	-0.2	-2.0
Birth weight of first child	1.2	2.2	6.8	-0.0	1.7	2.6	-1.4	-0.3	-1.3
Peak expiratory flow (PEF)	0.0	0.0	0.1	0.1	0.0	0.1	0.3	0.0	0.3
Pulse wave reflection index	0.3	0.3	1.3	0.6	-0.2	-0.2	0.0	-1.1	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	0.3	0.5	-0.4	0.2	0.0
Loud music exposure frequency	0.3	0.3	1.1	-0.7	-0.2	-1.1	0.1	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.0	-1.0	-2.0	-1.7	1.9	-0.5	1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.3	0.6	2.3	0.2	-1.6	1.0	0.5
Blood clot in the leg (DVT)	0.4	0.5	1.8	1.4	0.9	0.3	0.2	-0.3	0.5
Medication: Paracetamol	0.3	0.5	0.9	-0.9	0.6	0.9	-0.9	0.1	-0.5
Headache pain in last month	0.5	0.8	1.8	-0.5	1.2	1.1	-1.3	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.0	-2.2	0.1	0.2	-1.2	-1.2	0.6
Glaucoma (self-reported)	0.6	0.8	2.5	1.6	0.5	0.4	0.2	1.2	0.4
Gout (self-reported)	0.1	0.1	0.3	0.0	0.4	0.4	-0.3	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.2	-0.4	-0.5	0.5	0.0	0.7
Medication: Amlodipine	0.4	0.6	1.4	-0.4	0.6	1.2	-0.8	-0.7	-0.7
Medication: Ventolin 100micrograms inhaler	2.5	3.2	12.3	3.5	-0.4	-0.1	1.8	1.6	0.8
Birth weight	0.5	1.2	3.1	1.0	-1.2	-0.4	1.8	0.7	0.8
Chronic bronchitis/emphysema (mother)	3.4	4.0	8.9	2.0	-1.4	-0.3	3.0	1.7	2.4
High blood pressure (siblings)	2.0	2.9	5.6	2.2	-1.2	-1.4	1.9	0.4	2.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	0.3	-0.1	-0.8	1.0	0.6	0.8
Body fat percentage	0.4	1.7	9.2	0.4	-0.1	0.1	-0.1	3.0	1.0
Leg fat percentage (right)	0.4	1.3	7.1	0.1	0.3	-0.5	-0.5	2.7	0.4
Arm fat-free mass (right)	0.4	2.2	4.4	0.6	1.6	2.0	-0.7	2.1	-1.1
Exposure to tobacco smoke outside home	2.1	2.7	5.9	1.3	1.5	2.4	-0.9	1.9	-1.4
Comparative body size at age 10	0.4	1.1	6.1	-0.3	0.0	0.3	-0.2	-0.6	-2.5
Number of full brothers	0.4	0.5	1.4	-0.3	-0.7	-0.6	1.2	-0.0	0.8
Worry too long after embarrassment	0.5	0.8	1.5	-0.8	0.8	1.2	-1.0	-0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.9	0.3	-0.8	-1.7	1.1	1.5	0.9
Wheeze or whistling in the chest in last year	0.8	1.4	3.8	1.9	-0.8	-0.1	1.5	0.8	1.1
Number of children fathered	1.7	2.0	3.6	-1.7	1.2	0.1	-1.9	-0.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.0	-0.2	-0.7	-0.2	-0.2	-0.7
Age at first live birth	0.2	0.4	0.7	0.2	-0.8	0.6	0.8	-0.2	0.8
Pulse wave peak to peak time	0.2	0.2	0.7	-0.2	-0.3	-0.1	0.9	0.5	0.4
Health satisfaction	0.3	0.4	1.0	0.9	-0.1	0.4	0.3	1.0	0.8
Shortness of breath walking on level ground	1.2	1.4	3.4	1.8	-0.4	-0.5	1.0	1.9	0.5
Qualifications: College or University degree	0.8	2.6	4.1	-1.5	-2.0	-0.9	1.1	-1.9	2.0
Eye problems/disorders: None of the above	0.5	0.6	1.9	-0.7	-1.1	0.0	0.4	-1.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.3	-0.4	0.1	0.7	-0.2	-0.2
Emphysema/chronic bronchitis	1.7	1.9	5.6	2.4	-0.1	0.3	0.8	1.7	1.4
Medication for pain relief, constipation, heartburn	1.3	2.2	6.0	-1.4	-1.5	-1.6	0.8	-2.4	0.4
Neck or shoulder pain in last month	0.6	0.8	2.1	1.1	1.2	0.2	-0.3	1.5	-0.2
Medication: Blood pressure	0.7	1.2	4.0	2.0	0.2	-0.2	0.9	1.4	-0.6
Angina (self-reported)	0.2	0.3	0.9	0.6	-0.7	-0.2	0.1	-0.2	0.9
Migraine (self-reported)	0.4	0.5	1.0	-0.6	0.4	1.0	-0.9	-0.6	0.5
Medication: Ibuprofen	0.6	0.7	1.8	-0.1	1.3	0.5	-0.3	1.3	-0.3
Medication: Allopurinol	0.2	0.3	0.4	0.5	-0.5	-0.6	0.6	0.6	-0.2
Medication: Omeprazole	1.5	1.8	5.5	1.7	1.3	-0.6	0.3	2.3	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.6	-0.8	-0.9	0.4	-0.5	0.3
Mean time to correctly identify matches	0.3	0.5	1.8	0.9	0.3	-0.3	-0.2	1.4	0.2
Heart disease (mother)	0.5	0.6	1.3	0.3	-1.2	0.1	0.7	1.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	-0.7	-0.2	0.7	-0.5	-1.3	0.2
Whole body fat mass	0.6	2.3	12.0	0.9	0.5	0.7	-0.1	3.5	0.6
Leg fat mass (right)	0.6	2.2	10.8	0.6	1.0	0.5	-0.6	3.3	-0.1
Arm predicted mass (right)	0.4	2.2	4.2	0.5	1.7	2.1	-1.0	1.8	-1.1
Pulse rate, automated reading	0.1	0.3	1.4	0.2	-0.3	0.1	-0.1	1.2	-0.0
Alcohol intake frequency.	0.1	0.2	0.3	-0.6	0.2	0.1	-0.3	-0.3	-0.5
Comparative height size at age 10	0.2	1.3	2.9	1.3	-0.1	1.7	0.8	1.0	1.2
Number of full sisters	1.2	1.4	6.7	2.6	0.4	0.0	1.1	0.4	0.7
Suffer from ‘nerves’	0.2	0.2	0.8	0.0	0.5	0.0	-0.4	0.5	-0.9
Overall health rating	1.1	2.4	4.8	2.2	1.3	1.4	-1.1	2.2	-0.1
Chest pain or discomfort	2.1	3.0	7.9	2.8	0.0	0.7	0.7	2.0	2.3
Had major operations	2.7	3.1	5.5	1.2	-1.7	-1.7	2.4	1.2	2.1
Age at last live birth	0.2	0.3	0.7	0.0	-0.4	-0.1	-0.0	-0.8	0.8
Family relationship satisfaction	0.1	0.1	0.3	-0.3	0.2	-0.5	-0.2	0.6	0.1
Leg pain on walking	1.2	1.5	4.3	0.5	1.2	0.7	-1.4	0.4	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.1	-1.4	1.8	-0.2	-1.3	0.2	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.8	-2.0	0.8	-1.1	-0.9	0.0	-1.0
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	8.1	-2.9	-0.5	-1.1	-0.8	-2.1	-1.2
Medication: Aspirin	1.6	2.2	7.2	2.7	-0.7	0.6	0.8	1.9	1.0
Supplements: Vitamin C	0.6	0.8	2.4	-0.7	0.5	0.9	-1.5	-0.7	-0.1
Knee pain experienced in last month	1.9	2.9	7.3	2.3	1.5	1.4	-0.0	2.7	-0.7
Hypertension (Self-reported)	1.0	2.7	8.4	2.3	0.1	-0.2	0.4	2.9	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.4	0.3	1.0	-0.2	-1.1	-0.8	-1.2
Illnesses of father: Heart disease	0.9	1.2	2.8	1.2	-0.9	-0.7	1.7	1.4	-0.1
Illnesses of siblings: Diabetes	0.8	0.9	3.5	1.9	0.4	-0.0	1.2	0.2	0.8
Smoking status: Previous	0.3	0.4	2.1	0.6	0.1	-0.1	-0.3	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.0	0.4	0.7	-0.0	0.7	0.5
Whole body fat-free mass	0.4	2.1	5.0	0.6	1.7	2.2	-0.6	1.7	-1.1
Leg fat-free mass (right)	0.5	2.8	6.6	0.9	1.7	2.6	-0.5	2.4	-0.7
Arm fat percentage (left)	0.3	1.4	8.0	-0.2	0.1	0.2	-0.1	2.8	0.5
Average weekly red wine intake	0.7	1.1	2.3	1.5	-0.8	-1.2	0.4	0.7	1.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.5	-0.0	-0.3	1.0	0.1	-1.0
Mood swings	0.7	1.3	5.7	0.1	1.2	-0.1	-0.7	2.4	0.4
Loneliness, isolation	0.9	1.2	2.2	-1.0	1.4	0.3	-1.5	1.5	-0.0
Long-standing illness, disability or infirmity	1.6	2.4	9.2	3.0	0.7	0.7	0.7	1.9	0.6
Ever had bowel cancer screening	0.5	0.6	1.0	0.9	0.7	-1.0	0.2	0.6	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.8	0.2	0.2	0.1	0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	0.3	-0.5	0.5	0.0	1.3	1.3
Friendships satisfaction	1.5	1.8	7.1	-2.7	-0.7	-0.6	-0.4	-1.7	-0.1
Qualifications: nursing, teaching	2.1	3.3	7.6	-2.6	-2.8	-1.4	1.2	-1.0	1.1
Commuting to job workplace: Walk	0.6	0.6	1.6	0.8	-1.3	-0.1	0.8	-0.1	0.8
Eye problems/disorders: Cataract	1.0	1.1	2.8	-0.4	-0.9	-1.7	1.3	1.0	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.4	-0.1	0.3	-0.3	0.4	-0.1
Medication for cholesterol	0.3	0.5	1.4	-0.4	0.3	-0.6	0.1	-1.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	6.5	1.2	1.3	1.8	-0.6	2.5	-0.1
Back pain experienced in last month	0.3	0.5	1.4	1.2	0.8	0.6	0.3	0.5	-0.4
Mineral and other dietary supplements	1.1	1.5	5.7	0.5	1.3	2.4	-1.0	0.8	0.1
Breast cancer (self-reported)	0.4	0.5	2.1	-0.4	-0.2	-0.2	-0.0	-0.9	-1.5
Asthma (self-reported)	0.7	1.3	3.0	1.7	-0.1	-1.0	0.7	1.2	1.3
Osteoporosis (self-reported)	0.4	0.5	1.2	0.1	-0.7	-1.0	-0.2	-1.1	-0.5
Osteoarthritis (self-reported)	0.4	0.5	1.9	0.7	0.4	0.3	-0.3	1.4	-0.4
Medication: Aspirin	1.8	2.4	6.2	2.5	-0.8	0.1	1.2	2.0	1.3
Medication: Gliclazide	0.8	0.9	3.0	-1.0	0.7	0.8	-1.7	0.0	-0.2
Illnesses of father: None of the above (group 1)	1.7	2.1	4.2	-1.9	1.5	0.9	-2.0	-1.2	-0.1
Smoking status: Current	0.3	0.5	2.0	1.4	0.0	0.5	0.7	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	0.3	0.2	-0.1	0.3	-0.3
Whole body water mass	0.3	2.0	4.9	0.6	1.5	2.2	-0.5	1.6	-1.1
Leg predicted mass (right)	0.5	2.7	6.4	0.8	1.6	2.5	-0.5	2.4	-0.7
Arm fat mass (left)	0.4	1.6	8.2	0.3	0.6	0.8	-0.3	2.9	-0.1
Number of self-reported non-cancer illnesses	1.7	2.9	7.8	2.4	-0.4	0.2	0.7	2.8	1.8
Average weekly champagne plus white wine intake	0.5	0.7	2.5	-0.5	0.2	0.6	-0.5	-1.0	-1.6
Miserableness	0.6	1.1	3.2	0.0	-0.4	-0.5	0.7	1.6	1.8
Guilty feelings	0.5	0.7	2.6	0.8	0.5	0.3	0.5	1.6	-0.4
Wears glasses or contact lenses	1.6	1.9	4.8	-1.6	-2.2	-0.8	1.6	-0.7	-0.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	-0.8	1.1	-0.6	-1.2	-0.4	-0.6
Hearing aid user	0.5	0.5	2.1	-0.5	-0.6	-0.2	0.5	-0.2	1.4
Mother’s age at death	0.2	0.3	0.7	-0.8	-0.4	0.1	-0.3	-0.8	0.2
Financial situation satisfaction	0.8	1.0	2.8	0.7	1.0	0.6	-1.7	1.1	-0.5
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.7	0.1	-1.3	-1.9	0.7	-0.9	1.6
Commuting to job workplace: Public transport	0.9	1.1	4.1	2.0	-0.2	1.1	0.5	-0.2	0.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.0	-0.0	0.1	-0.1	0.3	0.5
Medication: Blood pressure	0.5	0.9	1.5	0.8	0.1	1.0	-0.9	1.2	1.2
Pain type(s) experienced in last month: Hip pain	1.4	1.7	6.1	2.5	0.1	-0.1	1.1	1.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	-0.0	-0.6	-1.8	0.5	-0.9	-0.6
High cholesterol (Self-reported)	0.9	1.5	5.9	0.5	0.7	1.3	-0.8	0.0	-2.4
Medication: Bendroflumethiazide	0.4	0.6	2.1	-0.7	0.1	-0.6	-1.5	0.7	0.6
Medication: Paracetamol	0.2	0.4	0.8	-0.7	0.7	0.9	-0.4	0.3	-0.3
Medication: Lisinopril	1.0	1.3	2.8	1.7	0.7	1.0	0.1	1.5	1.1
Medication: Atorvastatin	3.7	4.5	7.3	2.1	-2.0	-2.5	2.7	1.2	2.0
Illnesses of father: High blood pressure	0.4	0.5	2.2	-0.2	-0.6	-0.2	0.4	-1.5	-0.1
Alcohol drinker status: Never	0.4	0.4	1.2	-0.4	0.3	0.6	-0.5	-1.1	-0.7
Ever smoked	0.3	0.6	1.1	1.1	-0.8	-0.6	1.0	0.5	-0.1
Basal metabolic rate	0.4	2.2	4.6	0.6	1.6	2.1	-0.6	2.1	-0.9
Leg fat percentage (left)	0.4	1.5	7.7	0.3	0.3	-0.6	-0.5	2.8	0.6
Arm fat-free mass (left)	0.3	1.4	2.9	0.7	1.3	1.5	-0.5	1.7	-0.8
Number of operations (self-reported)	0.6	1.0	5.0	2.2	0.4	0.0	0.4	0.6	-0.1
Average weekly beer plus cider intake	1.6	2.4	6.6	0.6	2.6	0.8	-2.0	0.9	-1.2
Irritability	0.3	0.5	1.2	-1.1	0.5	-0.1	-0.5	1.0	-0.3
Risk taking	0.8	1.2	3.0	1.5	0.2	-0.4	0.1	1.7	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.5	1.1	-1.3	0.3	1.6	-0.8	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.5	0.6	-0.0	-1.1	0.1	-0.9
Age started oral contraceptive pill	1.3	1.7	4.4	-2.1	-1.1	-0.8	-0.5	-1.8	-0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.8	1.1	-0.0	0.1	-0.1	1.3	0.8
Ever depressed for a whole week	0.4	0.5	1.2	1.1	0.2	0.8	0.3	0.7	0.6
Unable to work because of sickness or disability	1.2	1.6	3.6	1.2	1.2	0.8	-0.8	1.9	-1.2
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.2	0.6	0.6	-0.8	0.3	0.4
Myopia	0.9	1.3	3.6	-0.4	-1.2	-1.4	0.5	-1.9	0.7
Vascular/heart problems diagnosed by doctor	0.6	1.8	4.1	-1.7	0.3	0.0	-0.3	-2.0	-1.9
Cholesterol lowering medication	0.5	0.7	2.6	0.5	0.0	1.6	-0.4	-0.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	4.4	2.1	0.9	-0.5	0.6	1.6	-0.6
Pain experienced in last month	1.1	1.8	3.9	-2.0	-1.7	-0.4	0.4	-1.8	0.7
Supplements: Calcium	0.6	0.6	1.6	-0.2	-0.8	-1.2	0.9	-0.1	0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.5	0.1	-0.9	0.1	-0.9	-0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.3	2.1	-0.6	0.1	1.5	1.3	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.2	1.5	0.6	0.2	0.6	0.1	1.0
Heart disease (siblings)	1.3	1.6	6.0	2.4	-0.4	-1.1	1.1	0.0	1.0
Alcohol drinker status: Previous	0.6	0.7	1.7	-1.1	0.4	-0.5	-0.9	-0.4	-1.3
Pack years of smoking	0.3	0.5	1.6	-0.2	0.6	-0.8	-0.5	1.2	-0.1
Impedance of whole body	0.6	3.0	8.8	0.4	-1.9	-1.7	1.5	-0.4	3.0
Leg fat mass (left)	0.6	2.4	11.9	0.8	1.1	0.5	-0.6	3.5	-0.0
Arm predicted mass (left)	0.3	1.6	2.9	0.7	1.4	1.6	-0.7	1.7	-1.0