TWAS hub - CD2BP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.135	0.0450	8.4e-05	0.028	NA	0.040	NA	0.040	5.3e-03	NA	1.0e-03	NA	1.1e-03
2	YFS	Blood	0.194	0.0338	0.0e+00	0.095	0.113	0.104	0.132	0.103	1.8e-29	4.8e-35	3.2e-32	7.1e-41	6.5e-32
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.033	0.0220	7.3e-03	0.038	0.039	0.027	NA	0.023	2.9e-03	2.8e-03	1.1e-02	NA	1.7e-02
4	TCGA	Rectum Adenocarcinoma	0.364	0.1750	8.8e-05	0.112	0.177	0.250	NA	0.199	1.4e-03	6.0e-05	1.4e-06	NA	2.0e-05
5	TCGA	Thyroid Carcinoma	0.078	0.0370	2.3e-09	0.100	0.108	0.107	NA	0.102	5.5e-10	1.2e-10	1.4e-10	NA	3.9e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Red Count	7.6	73.3	174.2	-5.0	-5.4	-13.2	-5.0	-10.6
Primary Biliary Cirrhosis	6.7	9.5	13.1	3.0	1.4	3.6	3.5	3.3
Knee pain experienced in last month	6.3	9.8	15.4	3.9	1.3	3.3	3.5	2.9
Eye problems/disorders: None of the above	5.9	6.8	10.8	2.8	0.7	2.8	3.3	2.6
Neuroticism (Nagel 2018)	5.6	13.1	17.2	3.8	3.0	3.0	3.9	4.2
Depressed Affect (Nagel 2018)	5.4	11.4	14.9	3.1	2.0	3.8	3.7	3.9
Worrier / anxious feelings	5.4	10.3	15.6	3.9	2.5	2.2	3.6	3.4
Pulse wave reflection index	5.3	6.5	9.5	3.0	0.4	2.7	3.1	2.6
Neuroticism	5.0	12.0	14.9	3.4	2.7	3.3	3.9	3.8
Medication: Ventolin 100micrograms inhaler	4.9	6.3	8.9	2.2	2.2	3.0	2.6	2.5
Medication: Aspirin	4.7	6.1	11.9	-2.0	-1.4	-3.4	-2.6	-2.4
Worry (Nagel 2018)	4.6	9.7	18.0	4.2	2.5	1.2	3.7	3.1
Medication: Aspirin	4.6	6.1	12.6	-1.9	-1.3	-3.5	-2.5	-2.6
Wheeze or whistling in the chest in last year	4.4	7.9	12.9	2.2	2.4	3.5	1.8	3.6
Medication: Omeprazole (e.g. Zanprol)	4.2	5.1	6.3	2.5	2.4	1.8	2.0	2.4
Ulcerative Colitis	4.1	5.9	8.9	2.0	1.6	3.0	2.4	2.8
Number of children fathered	4.1	4.6	9.4	1.8	0.6	3.1	2.0	2.4
Mood swings	4.1	7.4	11.3	3.0	0.7	3.1	3.4	2.6
Eye problems/disorders: Cataract	4.1	4.7	12.4	-1.5	-0.2	-3.5	-2.1	-2.1
Mother’s age at death	4.1	5.2	7.8	-2.8	-1.5	-1.6	-2.4	-2.8
Number of incorrect matches in round	3.9	6.6	15.8	-1.5	-1.7	-4.0	-1.9	-2.9
Fed-up feelings	3.8	6.8	10.2	1.8	2.5	3.2	2.2	3.1
Nervous feelings	3.8	7.1	15.2	3.9	1.9	0.5	3.6	1.8
Neuroticism score	3.7	7.7	12.6	2.9	1.6	2.7	3.6	2.7
Chronic bronchitis/emphysema (mother)	3.6	4.2	6.6	2.6	0.6	2.0	2.4	2.1
Asthma (self-reported)	3.6	7.3	11.6	2.1	2.2	3.4	2.2	3.2
Medication: Levothyroxine sodium	3.4	5.8	9.1	-2.4	-1.3	-2.9	-2.1	-3.0
Supplements: Vitamin C	3.4	4.0	5.6	-2.2	0.2	-2.4	-2.3	-2.1
Basal cell carcinoma (self-reported)	3.4	4.1	6.8	-2.3	0.1	-2.6	-2.4	-1.5
Ulcerative Colitis (UC)	3.3	6.2	9.4	2.4	1.8	3.1	2.4	2.6
Asthma	3.3	6.5	9.6	1.9	2.4	3.1	2.0	3.1
Maternal smoking around birth	3.2	4.6	6.2	2.1	1.1	2.4	2.3	2.5
Impedance of leg (right)	3.0	14.6	47.3	-1.4	-0.6	-6.9	-3.1	-3.7
Neuroticism (2016)	2.9	4.1	6.6	1.9	2.6	1.3	1.9	2.2
Impedance of leg (left)	2.9	14.1	43.4	-1.6	-0.8	-6.6	-3.3	-3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	8.6	1.3	0.3	2.9	1.8	1.9
Mouth/teeth dental problems: Mouth ulcers	2.9	4.6	6.1	2.5	1.6	2.0	2.4	2.2
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.8	2.4	1.3	1.5	2.6	1.7
Falls in the last year	2.8	3.8	6.3	-2.3	0.8	-2.0	-2.5	-1.7
Family relationship satisfaction	2.8	3.5	9.1	-1.3	1.6	-3.0	-1.2	-1.7
Diabetes (father)	2.7	3.3	7.8	-2.8	-0.4	-0.5	-2.5	-1.4
Loud music exposure frequency	2.6	2.9	4.2	2.1	1.0	1.4	1.9	1.9
Hayfever/allergic rhinitis (self-reported)	2.5	3.2	5.6	2.2	-0.0	1.2	2.4	2.0
Emphysema/chronic bronchitis	2.4	2.7	5.4	1.4	1.1	2.3	1.2	1.8
Hypothyroidism/myxoedema (self-reported)	2.3	4.4	9.0	-1.8	0.2	-3.0	-1.9	-2.5
Suffer from ‘nerves’	2.3	3.5	9.2	3.0	0.9	-0.5	2.4	1.3
Pain experienced in last month	2.3	3.8	7.4	-2.7	-0.2	-1.7	-2.5	-1.5
Hypothyroidism (self reported)	2.2	5.1	11.8	-1.8	0.2	-3.4	-1.7	-2.8
Respiratory disease	2.1	4.8	11.7	1.2	2.0	3.4	1.1	2.4
Sensitivity / hurt feelings	2.1	3.6	6.5	2.2	1.7	1.0	1.7	2.6
Medication for hormone replacement therapy	2.1	2.3	4.4	-1.1	-1.3	-2.1	-1.2	-1.6
Taking other prescription medications	2.1	3.3	5.4	1.6	2.1	1.4	1.4	2.3
Heart disease (mother)	2.1	2.5	4.0	1.5	0.5	2.0	1.6	1.9
Age at last live birth	2.1	3.0	5.4	-1.6	-1.4	-2.0	-1.1	-2.3
Impedance of whole body	2.1	10.5	34.7	-1.2	-0.6	-5.9	-2.7	-3.0
Waist Hip Ratio (WHR)	2.0	8.8	10.8	-3.0	-3.1	-2.7	-2.8	-3.3
Past tobacco smoking	2.0	3.6	6.4	-2.3	-1.5	-1.3	-1.5	-2.5
Smoking status: Previous	2.0	3.0	5.0	2.2	1.2	1.1	1.6	2.2
Miserableness	1.9	3.3	6.0	1.8	-0.0	2.2	2.4	1.5
Qualifications: None of the above	1.8	3.8	6.2	1.9	2.1	1.2	1.7	2.5
Serious illness, injury or assault to yourself	1.7	2.1	3.4	-1.7	-0.6	-1.4	-1.4	-1.8
Body mass index (BMI)	1.7	7.1	26.8	0.6	0.6	5.2	1.2	2.6
Pulse rate	1.7	2.9	4.3	-2.0	-0.2	-1.9	-2.1	-1.7
Birth weight of first child	1.7	3.1	5.2	1.3	1.6	2.0	1.4	2.3
Ever had hysterectomy (womb removed)	1.6	1.8	4.8	-0.7	0.0	-2.2	-1.8	-0.6
Sitting height	1.6	11.6	18.8	-4.3	-1.2	-3.8	-3.6	-3.2
Medication: Omeprazole	1.6	1.9	2.4	1.5	1.6	1.4	1.1	1.4
Reaction Time	1.5	2.8	3.9	2.0	1.6	1.2	1.6	2.0
Chronic bronchitis/emphysema (father)	1.5	1.8	2.6	1.6	1.4	0.9	1.0	1.6
Headache pain in last month	1.5	2.6	4.2	2.1	0.5	1.8	1.6	1.8
Number of full brothers	1.5	1.8	4.2	-0.8	-0.8	-1.5	-1.1	-2.1
Health satisfaction	1.5	1.9	2.9	-1.3	-0.1	-1.7	-1.5	-1.6
Neck or shoulder pain in last month	1.5	2.1	5.9	0.8	0.1	2.4	1.5	1.4
Diabetes (mother)	1.4	1.8	3.8	-1.2	-1.7	-0.4	-0.6	-2.0
Financial difficulties in last 2 years	1.4	1.9	5.0	-1.5	-0.9	-0.9	-0.8	-2.2
Impedance of arm (right)	1.4	6.5	19.9	-1.2	-0.7	-4.5	-2.3	-2.3
Illnesses of siblings: Diabetes	1.4	1.7	2.9	-1.4	0.0	-1.6	-1.7	-1.0
Alcohol drinker status: Never	1.4	1.6	3.1	-1.8	0.5	-0.9	-1.7	-1.0
Irritability	1.4	2.4	4.3	1.3	0.8	1.9	2.1	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.3	2.1	0.9	-1.0	1.9	0.7
Medication: Lansoprazole	1.3	1.4	2.0	1.4	-1.3	1.3	1.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.4	-0.0	-1.1	-2.1	-0.4	-1.7
Shortness of breath walking on level ground	1.3	1.6	2.4	1.6	1.0	1.3	1.1	1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	1.7	0.7	0.9	1.4	1.4
Leg fat-free mass (right)	1.3	6.9	27.4	-1.2	0.2	5.2	0.7	2.3
Leg predicted mass (right)	1.3	6.7	26.4	-1.3	0.2	5.1	0.6	2.2
Arm fat mass (left)	1.3	5.4	21.8	-0.4	0.4	4.7	0.2	2.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.1	-1.0	0.2	-1.6	-0.8	-1.8
Depression (Nagel 2018)	1.2	1.8	3.2	1.8	1.2	0.6	1.5	1.3
Smoking Status	1.2	2.9	3.8	1.7	1.7	1.9	1.3	1.8
Leg fat-free mass (left)	1.2	6.3	24.6	-1.2	0.3	5.0	0.6	2.2
Leg predicted mass (left)	1.2	6.3	24.6	-1.2	0.3	5.0	0.6	2.2
Prospective memory result	1.2	1.5	4.4	-0.8	-2.1	-0.7	-0.8	-1.0
Standing height	1.2	11.8	32.6	-5.7	-1.1	-1.8	-4.0	-2.4
Pulse rate, automated reading	1.2	3.8	5.8	-2.4	-0.8	-1.9	-2.2	-1.9
Average weekly red wine intake	1.2	1.7	2.3	-1.5	-0.7	-1.2	-1.5	-1.4
Back pain experienced in last month	1.2	1.7	2.6	1.6	0.8	1.5	1.3	1.3
Irritable Bowel Disease (IBD)	1.1	2.5	3.4	1.6	1.9	1.3	1.6	1.6
BMI	1.1	6.6	28.0	-0.6	0.4	5.3	0.2	2.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.9	-1.4	-1.2	-1.1	-1.2	-0.9
Diabetes (self-reported)	1.1	1.8	2.6	-1.6	0.6	-1.5	-1.3	-1.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.1	-1.0	-0.5	-2.5	-0.9	-2.0
Arm fat mass (right)	1.1	4.6	18.7	-0.6	0.4	4.3	-0.0	2.0
Medication: Paracetamol	1.1	1.9	3.5	1.5	1.9	0.8	0.9	1.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.2	1.1	-0.0	2.1	1.6	1.2
Medication for pain relief, constipation, heartburn	1.1	1.9	3.3	-1.5	-1.8	-0.6	-1.1	-1.5
Qualifications: nursing, teaching	1.1	1.6	2.4	-1.1	-1.1	-1.3	-1.3	-1.5
Breast cancer (self-reported)	1.1	1.3	4.2	0.3	2.1	0.7	0.1	1.3
Medication: Bendroflumethiazide	1.1	1.6	5.0	0.5	0.6	2.2	0.6	1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.5	-1.4	0.4	-1.1	-1.9	-0.4
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.8	2.2	0.6	1.3	1.7	1.4
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.3	-2.1	-0.1	-0.8	-1.4	-1.6
Lung FEV1/FVC ratio	1.0	5.2	16.6	0.4	-1.5	-4.1	0.5	-2.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.8	-1.1	0.2	-1.7	-0.9	-1.0
Medication: Atenolol	1.0	1.3	1.9	-1.0	-1.1	-1.0	-1.1	-1.4
Had menopause	1.0	1.3	3.6	-0.9	-0.2	-1.9	-1.2	-0.7
Mouth/teeth dental problems	1.0	1.5	3.2	-1.1	-0.7	-1.8	-1.0	-1.4
Fluid intelligence score	1.0	2.2	3.6	1.9	0.7	1.4	1.9	1.1
Hip circumference	1.0	4.5	17.4	-1.4	0.8	4.2	-0.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	-1.6	0.1	-0.8	-1.3	-0.9
Impedance of arm (left)	1.0	4.5	15.0	-0.8	-0.2	-3.9	-2.0	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	-0.9	-0.6	-1.5	-1.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.6	-0.5	-1.2	-1.2	-1.1	-1.3
Chest pain or discomfort	1.0	1.5	3.2	-1.1	0.2	-1.8	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	5.9	-2.4	-0.6	0.3	-1.9	-0.6
Commuting to job workplace: Walk	1.0	1.1	1.7	-1.3	-0.9	-0.9	-0.9	-1.3
Medication: Gliclazide	1.0	1.1	2.6	-1.6	0.6	-0.4	-1.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.8	-0.0	-1.3	-1.3	-0.6	-1.7
Mean Putamen Volume	0.9	1.1	3.3	0.2	-0.3	1.8	0.7	1.2
Blood Eosinophil Count	0.9	7.0	16.4	-0.6	-2.1	-4.0	-1.1	-3.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.7	-0.1	1.4	-1.6	-0.5	-0.3
Weight	0.9	4.4	16.3	-1.9	0.2	4.0	-0.7	1.4
Happiness	0.9	1.1	2.6	-0.4	-0.5	-1.6	-0.1	-1.6
Medication: Cholesterol lowering	0.9	1.3	5.2	-0.0	0.5	-2.3	-0.9	-0.7
Comparative body size at age 10	0.9	2.4	8.0	1.0	-1.2	2.8	0.9	0.8
Alcohol intake frequency.	0.9	2.1	5.7	-2.4	0.7	0.5	-1.8	-0.9
Illnesses of father: Heart disease	0.9	1.3	3.6	-1.1	0.3	-1.1	-1.9	-0.4
Arm fat percentage (left)	0.9	3.8	14.4	0.1	0.6	3.8	0.1	2.0
Friendships satisfaction	0.9	1.1	2.4	1.4	0.9	-0.2	1.6	0.4
Whole body water mass	0.9	4.9	18.3	-2.0	-0.1	4.3	0.0	1.4
Basal metabolic rate	0.9	5.2	19.6	-2.0	-0.1	4.4	-0.1	1.5
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	1.5	1.0	-0.1	1.4	1.0
Height	0.8	16.1	45.3	-6.7	-1.4	-1.0	-4.9	-2.9
Number of treatments/medications taken	0.8	1.5	4.7	0.5	2.2	0.0	-0.5	1.5
Vitamin and mineral supplements	0.8	1.0	1.9	0.9	-1.4	0.9	1.2	0.4
Waist circumference	0.8	2.9	8.1	-2.0	-0.6	2.9	-1.4	0.5
Heart attack	0.8	1.1	2.7	-1.2	0.7	-0.9	-1.6	-0.1
Arm fat percentage (right)	0.8	3.0	11.9	-0.1	0.4	3.5	-0.1	1.7
Time employed in main current job	0.8	0.9	1.5	-0.9	0.3	-1.2	-1.2	-0.9
Peak expiratory flow (PEF)	0.8	1.9	3.5	-1.9	-1.2	-0.7	-1.2	-1.5
Blood clot in the leg (DVT)	0.8	1.0	2.3	0.1	-1.2	-1.1	-0.6	-1.5
Arm fat-free mass (right)	0.8	4.0	14.7	-1.9	-0.3	3.8	-0.1	1.3
Qualifications: College or University degree	0.8	2.6	4.2	-0.9	-1.8	-2.0	-1.0	-2.0
Whole body fat-free mass	0.8	4.7	17.2	-2.0	-0.2	4.2	-0.0	1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	0.8	-1.0	1.2	1.4	0.1
Age started oral contraceptive pill	0.8	1.0	2.2	0.7	1.3	0.6	0.5	1.5
Bipolar Disorder (2018)	0.7	1.1	2.2	-0.8	0.3	-1.5	-1.2	-1.0
Blood White Count	0.7	5.1	14.8	-1.6	0.6	-3.9	-2.2	-1.7
Hand grip strength (left)	0.7	1.9	8.7	-0.5	-0.2	2.9	0.4	0.7
Trunk predicted mass	0.7	3.8	10.2	-2.8	-0.7	3.2	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.5	1.4	-0.5	-0.3	1.6	-0.5
Whole body fat mass	0.7	2.8	10.8	-0.9	0.4	3.3	-0.5	1.5
Arm predicted mass (right)	0.7	3.8	13.6	-2.0	-0.3	3.7	-0.0	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.3	0.8	1.4	-0.2	1.1
Wears glasses or contact lenses	0.7	0.8	2.3	0.2	1.5	0.3	-0.2	1.2
Medication: Blood pressure	0.7	1.4	3.9	0.9	0.6	2.0	0.9	1.0
Arm fat-free mass (left)	0.7	3.6	12.8	-2.0	-0.2	3.6	-0.3	1.2
Leg fat mass (left)	0.7	2.7	10.6	-0.7	0.3	3.3	-0.5	1.4
Arm predicted mass (left)	0.7	3.5	11.2	-2.3	-0.5	3.4	-0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.5	-0.1	0.1	-1.9	0.1	-0.7
Medication: Co-codamol	0.6	0.7	2.2	0.4	0.8	1.5	0.4	0.6
Severe depression (siblings)	0.6	0.7	0.9	0.7	0.8	0.9	0.9	0.9
Age when periods started (menarche)	0.6	1.3	3.5	-0.0	-1.2	-1.9	0.2	-1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.9	0.6	1.2	1.2	0.8	1.7
Multivitamins +/- minerals	0.6	0.8	1.3	-1.1	0.6	-0.9	-1.0	-0.5
High blood pressure (mother)	0.6	0.8	2.6	-0.2	0.1	1.6	0.2	1.1
Medication: Ramipril	0.6	0.8	1.5	-1.0	0.1	-0.8	-1.2	-0.9
Trunk fat-free mass	0.6	3.7	10.1	-2.7	-0.7	3.2	-0.7	0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.7	0.5	-0.3	1.9	0.6	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.3	-1.8	-1.8	-1.0	-0.7	-1.4
Tense / ‘highly strung’	0.6	0.9	1.7	1.3	1.0	-0.6	1.2	0.6
Age at first live birth	0.6	1.1	2.0	-1.4	0.3	-1.1	-1.4	-0.5
Migraine (self-reported)	0.6	0.8	1.8	1.4	0.3	0.7	0.8	0.8
Leg fat mass (right)	0.6	2.5	9.8	-0.6	0.4	3.1	-0.4	1.4
Comparative height size at age 10	0.6	3.5	12.0	-3.5	0.1	0.5	-2.1	-0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	-1.0	-0.4	-0.5	-1.0	-1.0
Diabetes diagnosed by doctor	0.6	1.0	1.3	-1.1	1.1	-1.1	-1.0	-0.7
Osteoporosis (self-reported)	0.6	0.7	2.2	-1.5	-0.0	-0.1	-1.1	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-1.2	-0.2	0.3	-1.4	0.0
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.8	1.0	0.7	0.4	1.1
Ever smoked	0.6	1.0	1.9	1.4	0.5	0.8	0.9	1.2
Risk taking	0.6	0.9	1.9	-1.1	-0.4	-0.3	-1.0	-1.4
Bipolar Disorder or Schizophrenia	0.5	1.2	4.8	0.1	0.5	-2.2	-0.6	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	1.1	-0.2	0.7	1.0	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	0.8	0.8	-1.1	0.5	0.0
Systolic Blood Pressure	0.5	2.6	3.4	-1.8	-1.3	-1.6	-1.6	-1.7
Supplements: Zinc	0.5	0.5	1.2	-0.9	1.1	-0.4	-0.5	-0.2
Medication: Metformin	0.5	0.6	1.1	-0.9	1.0	-0.6	-0.8	-0.5
Hand grip strength (right)	0.5	1.3	5.1	-0.9	-0.8	2.3	-0.1	0.4
Relative age voice broke	0.5	0.7	1.8	1.3	0.1	-1.1	0.5	0.5
Trunk fat mass	0.5	2.2	6.9	-1.3	0.3	2.6	-1.0	1.2
Hearing difficulty/problems with background noise	0.5	0.9	2.2	-0.9	0.4	-1.5	-1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	0.7	-0.2	-1.0	0.4	-1.0
Allergy	0.5	1.2	2.1	-1.0	-1.0	-1.2	-0.8	-1.4
Breastfed as a baby	0.5	0.6	1.1	-0.6	-1.1	-0.5	-0.2	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.7	4.9	-2.2	-1.5	0.1	-1.0	-0.7
Worry too long after embarrassment	0.5	0.8	1.9	0.6	1.4	0.3	1.1	0.8
Medication: Blood pressure	0.5	0.9	1.7	-1.3	-0.4	-0.6	-1.1	-0.9
Mean time to correctly identify matches	0.5	1.0	1.7	1.3	1.2	-0.1	0.9	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	0.6	0.7	1.1	0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	0.6	1.1	-0.2	0.8	0.2
Average weekly champagne plus white wine intake	0.5	0.6	1.4	1.2	-0.3	-0.7	1.1	-0.2
Ever taken oral contraceptive pill	0.5	0.5	0.7	-0.9	-0.8	0.5	-0.6	-0.8
High cholesterol (Self-reported)	0.5	0.9	2.4	-0.3	-0.3	-1.6	-1.2	-0.7
Medication: Paracetamol	0.5	0.8	2.3	0.8	1.5	-0.2	0.1	1.1
Medication: Lisinopril	0.5	0.7	1.9	0.3	0.3	1.4	0.8	0.8
Myopia	0.5	0.7	1.6	-0.3	-0.4	-1.3	-0.1	-1.3
Pack years of smoking	0.5	0.8	1.7	-0.7	-0.2	-0.7	-1.3	-1.0
Rheumatoid Arthritis	0.4	0.5	0.9	-0.6	-0.9	0.9	-0.3	-0.5
Schizophrenia (2014)	0.4	1.0	3.7	0.2	0.9	-1.9	-0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.1	-1.4	-0.5	0.0	0.0	0.0
Allergy or Eczema	0.4	1.1	2.4	0.5	1.6	0.3	0.4	1.6
Qualifications: CSEs or equivalent	0.4	0.5	1.1	0.3	0.3	1.1	0.6	0.8
Forced vital capacity (FVC)	0.4	1.4	4.0	-2.0	-1.4	0.9	-0.6	-0.3
Medication: Simvastatin	0.4	0.5	1.5	0.7	0.7	-1.2	-0.4	-0.2
Medication: Amlodipine	0.4	0.6	0.9	-0.8	-0.7	-0.9	-0.4	-1.0
Pulse wave peak to peak time	0.4	0.5	1.2	-1.1	0.2	-0.0	-0.9	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.7	0.2	0.4	1.3	-0.0	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.6	-0.2	1.2	0.8	0.5
Diastolic blood pressure, automated reading	0.4	1.1	2.0	-1.2	-0.2	-1.2	-1.4	-0.9
Ever depressed for a whole week	0.4	0.5	0.9	1.0	-0.5	0.0	1.0	-0.6
Schizophrenia (2018)	0.3	0.7	2.6	0.7	0.2	-1.6	0.2	-0.4
Major Depression (MDD)	0.3	0.4	1.2	1.1	-0.6	0.3	0.4	0.5
Chronotype (morning person)	0.3	0.7	1.6	-0.4	0.6	1.3	-0.4	1.0
Pack years adult smoking proportion	0.3	0.4	1.2	-0.5	-0.1	-0.4	-1.1	-0.7
Trunk fat percentage	0.3	1.2	3.3	-0.6	0.6	1.8	-0.9	1.1
Illnesses of siblings	0.3	0.4	1.2	0.6	-0.2	0.7	1.1	0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.1	1.2	0.7	-0.3	0.5
Number of live births	0.3	0.4	0.8	0.9	0.1	-0.7	0.7	-0.1
Noisy workplace	0.3	0.4	1.1	0.7	0.5	0.2	1.1	0.3
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.6	-0.7	0.5	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.2	-1.1	0.1	-0.3	-0.6	-0.1
Glaucoma (self-reported)	0.3	0.3	0.7	-0.8	0.3	0.6	-0.7	0.2
Birth weight	0.3	0.7	1.5	0.3	0.7	1.0	0.7	1.2
Body fat percentage	0.3	1.3	4.2	-0.4	0.5	2.0	-0.7	1.1
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.1	-0.3	-0.9	-0.4	-0.9
Number of full sisters	0.3	0.4	1.6	0.3	-1.3	-0.2	0.3	-0.2
Smoking status: Current	0.3	0.5	1.0	-1.0	-0.1	0.1	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.0	1.0	-0.2	-0.8	0.7	0.7
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.7	-0.1	-1.0	-0.6	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.7	-0.3	-0.6	-0.8	-0.6
Leg fat percentage (left)	0.3	1.1	3.6	-0.2	0.6	1.9	-0.9	1.0
Number of operations (self-reported)	0.3	0.4	1.3	0.6	0.1	0.5	0.4	1.1
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.2	-0.4	-0.9	0.4	-0.7
Cholesterol lowering medication	0.3	0.5	1.3	0.1	-0.1	-1.1	-0.9	-0.4
Heart disease (siblings)	0.3	0.4	0.8	-0.6	-0.5	-0.9	-0.7	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.7	1.3	-0.2	0.6	0.9	0.6
Ovarian Cancer	0.2	0.2	0.8	0.5	-0.1	0.3	0.9	0.2
Fasting Glucose	0.2	0.3	0.7	0.9	0.6	0.0	0.4	0.2
HbA1C	0.2	0.2	1.1	-1.1	0.3	0.0	0.0	0.0
Lupus	0.2	0.4	0.8	0.9	0.5	-0.2	0.7	0.6
Heel T-Score	0.2	1.6	6.5	1.0	0.2	-2.5	0.4	-0.8
Lung FVC	0.2	0.8	2.1	1.0	-0.2	-0.0	1.4	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.2	-0.3	-0.9	-0.7	-0.5
Relative age of first facial hair	0.2	0.4	0.8	0.8	-0.3	-0.9	0.6	0.3
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.4	-0.8	-0.4	0.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	0.7	0.2	-0.0	0.8	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.5	-0.5	0.3	-0.8	0.3
High blood pressure	0.2	0.4	1.2	0.5	-0.0	1.1	0.8	0.4
Supplements: Glucosamine	0.2	0.3	0.6	-0.7	-0.6	0.8	-0.2	-0.1
Alcohol usually taken with meals	0.2	0.2	1.1	-0.2	-0.2	1.1	-0.2	0.1
Had other major operations	0.2	0.2	0.9	0.4	-0.0	0.3	0.1	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.5	-0.7	-0.5	0.9	-0.4
Father’s age at death	0.2	0.3	1.2	0.4	1.1	-0.2	0.2	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	0.2	-0.7	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.7	-1.3	-1.3	0.3	-0.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.2	0.2	0.2	1.1	0.2	0.5
Lung cancer (father)	0.2	0.3	0.6	0.1	0.8	0.7	0.4	0.4
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	0.8	-0.2	-0.0	0.7	0.5
Length of working week for main job	0.2	0.3	0.9	-0.0	0.3	0.9	-0.1	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.2	0.5	0.6	0.4	0.5
Leg fat percentage (right)	0.2	0.8	2.0	-0.2	0.7	1.4	-0.9	0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.1	0.4	0.7	0.3	0.5
Had major operations	0.2	0.3	0.5	0.0	-0.6	-0.6	0.3	-0.7
Leg pain on walking	0.2	0.2	0.8	0.3	-0.2	0.9	0.4	0.2
Loneliness, isolation	0.2	0.2	0.7	-0.5	-0.1	0.5	0.2	-0.8
Ever had bowel cancer screening	0.2	0.2	1.0	0.1	-0.2	-1.0	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.5	0.2	-0.7	0.5	-0.2
Mineral and other dietary supplements	0.2	0.2	0.7	0.8	0.3	-0.1	0.6	0.1
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	0.1	1.1	-0.5	-0.5	0.7
Guilty feelings	0.2	0.2	0.6	-0.0	-0.8	0.4	0.6	-0.2
Financial situation satisfaction	0.2	0.3	0.6	-0.4	0.8	-0.5	-0.3	-0.4
Medication: Atorvastatin	0.2	0.3	0.9	-0.0	-0.6	-1.0	-0.4	-0.1
Average weekly beer plus cider intake	0.2	0.2	0.5	0.7	-0.5	-0.5	0.2	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.1	0.6	-0.6	-0.3	-0.3
Unable to work because of sickness or disability	0.2	0.2	0.7	-0.1	-0.8	0.4	0.2	-0.4
Supplements: Calcium	0.2	0.2	0.8	-0.1	-0.4	-0.9	-0.1	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.1	0.7	-0.2	0.2	0.0
Crohns Disease (2017)	0.1	0.3	1.0	-0.0	0.6	-1.0	0.2	-0.3
Prostate Cancer	0.1	0.2	0.4	-0.1	0.7	-0.4	-0.2	0.4
Crohns Disease (2012)	0.1	0.2	0.8	0.9	0.4	0.0	-0.1	0.0
LDL Cholesterol	0.1	0.2	1.1	1.0	-0.1	0.0	0.0	0.0
Blood Platelet Count	0.1	1.4	4.9	2.2	0.7	0.4	0.8	0.8
Cardiovascular Disease	0.1	0.3	0.7	0.5	0.4	0.8	0.1	0.6
Tanning	0.1	1.7	2.9	1.7	0.6	0.7	1.6	1.4
Average weekly spirits intake	0.1	0.2	0.5	0.1	0.7	-0.1	0.0	0.6
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.4	-0.1	-1.0	-0.6	-0.3
Angina	0.1	0.1	0.3	-0.3	0.5	0.3	-0.0	0.1
Current tobacco smoking	0.1	0.2	0.3	-0.6	-0.1	0.5	-0.5	-0.4
Average weekly fortified wine intake	0.1	0.1	0.5	0.1	0.7	-0.1	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	0.7	-0.1	-0.6	0.8	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.5	-0.4	-0.1	-0.4	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.2	0.2	-0.1	-0.7	-0.1
Pain all over the body in last month	0.1	0.1	0.2	0.5	-0.1	-0.3	0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.3	-0.2	-0.6	0.3	-0.4
Depression (self-reported)	0.1	0.1	0.2	0.5	0.3	0.4	0.4	0.2
Illnesses of mother	0.1	0.1	0.2	-0.1	0.1	-0.4	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.4	-0.6	0.4	0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.1	0.4	0.1	0.6	-0.2
Gout (self-reported)	0.1	0.1	0.3	0.4	-0.6	0.1	0.3	0.3
Angina (self-reported)	0.1	0.1	0.4	-0.6	0.2	0.2	-0.3	-0.3
Medication: Ibuprofen	0.1	0.1	0.3	0.2	0.4	0.4	-0.0	0.5
Medication: Allopurinol	0.1	0.1	0.3	0.1	-0.5	-0.1	0.3	-0.5
Overall health rating	0.1	0.1	0.4	0.1	0.4	-0.6	-0.3	-0.1
Hypertension (Self-reported)	0.1	0.2	0.7	0.2	-0.2	0.9	0.6	-0.0
Medication for cholesterol	0.1	0.1	0.4	-0.6	0.3	-0.0	-0.1	0.1
Hearing aid user	0.1	0.2	0.4	0.0	-0.0	-0.6	-0.7	-0.0
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.2	-0.3	-0.0	0.4	-0.7
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.0	-0.3	0.3	-0.2	0.3
Breast Cancer	0.0	0.1	0.3	-0.0	-0.6	0.1	-0.2	-0.3
Age at First Birth	0.0	0.0	0.0	-0.2	0.1	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.0	0.3	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.3	0.3	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.2	0.5	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.3	0.5	0.7	-0.4	0.6	0.7	0.1
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.2	-0.2	-0.1	0.3	-0.1
High blood pressure (siblings)	0.0	0.1	0.1	0.3	0.0	-0.3	-0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.0	0.3
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.3	0.1	0.1	0.1	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.2	-0.2	-0.6	-0.2	-0.1

Hub : Genes

CD2BP2

Models

Trait associations