Hub : Genes

CD36

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0200 1.2e-04 0.035 0.035 0.031 0.034 0.034 3.7e-05 4.1e-05 1.1e-04 5.3e-05 4.7e-05
2 GTEx Esophagus Mucosa 0.2530 0.0830 9.6e-04 0.024 NA 0.025 NA 0.021 8.9e-03 NA 8.3e-03 NA 1.5e-02
3 METSIM Adipose 0.0462 0.0189 2.0e-03 0.034 0.017 0.037 0.025 0.045 7.0e-06 1.2e-03 2.7e-06 9.3e-05 2.1e-07
4 NTR Blood 0.0555 0.0138 1.1e-09 0.011 0.034 0.016 0.032 0.020 1.0e-04 2.6e-11 4.9e-06 1.0e-10 2.8e-07
5 YFS Blood 0.3706 0.0345 0.0e+00 0.282 0.315 0.353 0.325 0.345 3.3e-93 6.5e-106 9.4e-122 3.8e-110 3.7e-118
6 TCGA Brain Lower Grade Glioma 0.0668 0.0252 2.6e-05 0.047 0.030 0.026 NA 0.039 4.4e-06 2.3e-04 5.2e-04 NA 2.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 2.0 0.9 0.0 0.1 1.4 0.3 -0.7
Bipolar Disorder or Schizophrenia 0.4 1.1 4.8 2.2 0.0 0.8 0.6 -0.8 0.2
Depressed Affect (Nagel 2018) 0.7 1.4 4.5 -1.0 0.0 -2.1 -0.9 -0.2 -1.4
Depression (Nagel 2018) 1.9 2.8 8.5 -2.9 0.0 0.1 -0.7 -0.3 -2.8
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 0.1 0.0 -0.1 0.2 -1.0 -1.1
Neuroticism (Nagel 2018) 0.6 1.4 3.9 -1.2 0.0 -2.0 -0.7 0.6 -1.4
Schizophrenia (2018) 0.6 1.3 4.5 2.1 0.0 0.9 -0.4 -1.2 0.8
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 0.9 0.0 -0.8 -0.1 0.7 0.5
Worry (Nagel 2018) 0.3 0.6 1.4 -1.1 0.0 -1.2 -0.4 0.4 -0.8
Alzheimer’s Disease (in mother) 0.2 0.3 0.6 0.2 0.0 0.4 0.4 0.8 0.8
Alzheimer’s Disease (in father) 0.2 0.3 0.7 0.2 0.0 0.7 -0.4 -0.4 0.8
Alzheimer’s Disease (including proxy) 0.4 0.5 2.0 0.2 0.0 1.4 0.0 0.1 1.0
Crohns Disease (2017) 0.8 1.8 5.5 0.3 0.0 -2.4 0.1 2.1 -0.7
Irritable Bowel Disease (IBD) 0.8 1.8 5.0 0.3 0.0 -2.2 -0.3 2.0 -1.3
Ulcerative Colitis (UC) 0.5 0.9 2.6 -0.3 0.0 -1.1 -1.0 0.6 -1.6
Major Depression (MDD) 2.8 3.4 11.5 -0.2 0.0 0.4 -3.4 -2.0 -2.1
Reaction Time 0.3 0.6 2.2 -0.4 0.0 -0.7 1.5 0.3 -0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.1 0.1 0.0 0.3 1.0 -1.0 -0.6
Breast Cancer 0.2 0.4 1.8 -0.3 0.0 -0.4 0.5 0.1 1.4
Ovarian Cancer 0.1 0.1 0.4 -0.6 0.0 -0.2 0.2 -0.0 -0.2
Prostate Cancer 0.3 0.4 1.0 0.9 0.0 0.1 0.7 1.0 0.4
Age at First Birth 0.3 0.4 1.2 -0.2 0.0 1.1 1.0 0.3 -0.2
Bipolar Disorder (2011) 0.7 0.7 1.8 -0.7 0.0 0.0 -0.4 -1.3 -1.3
Body Mass Index (BMI) (2010) 1.0 1.4 4.5 2.1 0.0 1.0 0.1 0.4 1.7
Coronary Artery Disease (CAD) 0.7 0.8 2.6 0.6 0.0 1.0 -1.6 -0.7 -0.4
Crohns Disease (2012) 0.2 0.3 1.2 1.1 0.0 0.0 -0.8 0.0 0.4
Mean Putamen Volume 1.8 2.1 5.5 1.8 0.0 2.3 -1.0 -1.2 1.2
Fasting Glucose 1.4 1.7 5.2 2.1 0.0 -0.0 0.3 -0.4 2.3
HbA1C 0.3 0.4 0.9 1.0 0.0 0.5 -0.6 -0.6 0.6
HDL Cholesterol 1.5 2.4 5.4 2.0 0.0 1.4 0.6 -1.7 2.3
LDL Cholesterol 0.6 1.0 2.3 -1.5 0.0 -0.8 -0.7 0.5 -1.5
Lupus 0.3 0.5 0.9 0.9 0.0 -0.7 -0.8 -0.4 0.8
Neuroticism (2016) 0.3 0.5 1.5 -0.4 0.0 -0.7 0.2 1.2 -0.8
Primary Biliary Cirrhosis 0.4 0.5 1.3 -0.9 0.0 -0.5 -0.8 0.4 -1.1
Rheumatoid Arthritis 1.9 2.6 5.6 1.2 0.0 1.8 -1.2 -1.9 2.4
Schizophrenia (2014) 1.1 2.5 7.2 2.7 0.0 1.6 -0.8 -1.9 1.0
Triglycerides 0.1 0.1 0.4 -0.6 0.0 -0.5 -0.3 0.0 -0.3
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.9 0.9 0.0 -0.1 -1.0 -0.0 0.8
Ulcerative Colitis 0.1 0.2 0.3 0.2 0.0 -0.6 -0.5 0.4 -0.4
Blood Eosinophil Count 0.1 0.5 1.7 1.3 0.0 -0.8 -0.6 -0.2 0.6
Blood Platelet Count 4.5 52.0 97.8 7.5 0.0 6.2 -9.9 -9.0 6.2
Blood Red Count 4.3 41.9 102.0 -1.8 0.0 -10.1 7.0 9.3 -3.3
Blood White Count 0.1 0.7 2.5 -0.0 0.0 0.0 -1.2 1.6 -0.3
Heel T-Score 0.1 1.2 6.2 -0.1 0.0 2.5 0.4 -0.5 0.7
BMI 0.3 1.8 6.4 -1.2 0.0 -2.5 0.3 0.9 -1.4
Height 0.4 8.3 13.2 3.6 0.0 3.5 -2.0 -2.7 3.6
Waist Hip Ratio (WHR) 1.3 5.8 16.3 -0.0 0.0 -4.0 2.7 3.3 0.6
Systolic Blood Pressure 0.0 0.2 0.9 0.7 0.0 -0.1 -0.9 0.1 0.1
Smoking Status 1.2 2.9 7.1 -2.7 0.0 -1.2 -1.6 -0.1 -2.5
Allergy or Eczema 0.3 0.7 2.2 0.3 0.0 -0.2 1.5 0.4 1.2
Cardiovascular Disease 0.2 0.5 1.8 0.4 0.0 0.9 0.6 0.2 1.3
Hypothyroidism (self reported) 0.8 1.7 4.4 -0.4 0.0 -1.8 1.3 2.1 -1.1
Respiratory disease 0.1 0.2 0.6 0.4 0.0 0.4 -0.8 0.6 0.0
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.4 1.2 0.0 -0.3 0.6 -0.0 0.4
Lung FEV1/FVC ratio 0.3 1.5 3.6 -1.9 0.0 -1.2 -0.7 0.4 -1.9
Lung FVC 0.4 1.8 5.7 1.1 0.0 0.8 1.9 -0.1 2.4
Neuroticism 0.2 0.5 1.1 -0.9 0.0 -1.1 -0.7 0.6 -0.5
Chronotype (morning person) 0.2 0.3 0.8 -0.9 0.0 0.2 -0.8 -0.7 0.2
Hair Pigment 0.1 2.4 8.5 -0.8 0.0 1.9 -2.9 -0.9 -1.0
Tanning 0.0 0.3 0.9 0.2 0.0 0.4 0.8 0.9 0.0
Hand grip strength (left) 0.2 0.5 1.7 -0.2 0.0 1.0 -0.3 -1.3 0.4
Number of treatments/medications taken 0.1 0.2 0.5 -0.5 0.0 0.1 -0.5 0.4 -0.7
Average weekly spirits intake 1.9 2.3 6.8 0.1 0.0 -0.6 -2.6 -2.0 -1.6
Sensitivity / hurt feelings 1.3 2.2 10.0 -0.3 0.0 0.1 -3.2 -1.7 0.0
Frequency of depressed mood in last 2 weeks 1.0 1.3 4.0 -1.9 0.0 0.1 -0.4 0.1 -2.0
Hearing difficulty/problems: Yes 0.5 0.7 2.1 1.4 0.0 -1.0 -1.0 -0.5 0.1
Relative age of first facial hair 1.9 3.8 9.8 -0.7 0.0 1.5 -3.1 -2.9 -1.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.6 0.2 0.0 0.4 -1.3 -0.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.0 4.6 0.5 0.0 -0.1 1.0 2.1 0.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.8 1.3 0.0 0.1 -0.7 -1.1 -0.1
Systolic blood pressure, automated reading 0.1 0.3 1.1 0.9 0.0 -1.0 -0.0 -0.1 0.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 0.8 0.0 1.0 -0.7 -1.3 0.6
Angina 0.8 1.0 4.0 1.2 0.0 -2.0 -0.6 -0.4 0.1
Medication for hormone replacement therapy 0.7 0.8 1.6 0.6 0.0 1.1 1.1 1.3 0.5
Vitamin and mineral supplements 0.4 0.5 2.0 0.5 0.0 0.6 0.2 -1.4 0.7
Supplements: Zinc 0.9 1.0 3.7 0.4 0.0 -0.9 1.0 1.9 -0.5
Medication: Co-codamol 1.4 1.6 2.4 -1.4 0.0 1.4 -1.6 -1.5 -1.0
Medication: Metformin 0.1 0.1 0.5 0.5 0.0 0.3 0.7 0.1 0.2
Diabetes (father) 0.0 0.0 0.1 -0.2 0.0 0.2 0.3 -0.1 0.1
Diabetes (mother) 0.6 0.7 1.9 -1.0 0.0 -0.6 0.9 1.4 -0.5
Severe depression (siblings) 0.3 0.3 0.7 0.8 0.0 0.4 0.3 -0.5 -0.9
Pack years adult smoking proportion 0.3 0.4 1.5 0.5 0.0 -1.2 0.0 0.9 0.1
Impedance of leg (right) 0.1 0.5 2.1 -0.4 0.0 0.2 -1.4 -0.7 -0.3
Leg fat-free mass (left) 0.0 0.2 0.5 0.7 0.0 0.5 -0.6 -0.5 -0.3
Trunk fat percentage 0.2 0.6 2.5 -0.3 0.0 -0.6 -1.6 -0.1 -1.0
Hand grip strength (right) 0.3 1.0 4.2 0.2 0.0 0.6 2.1 0.2 1.0
Townsend deprivation index at recruitment 0.5 0.7 1.7 -0.8 0.0 -0.9 -1.3 -0.3 -0.9
Current tobacco smoking 1.4 2.3 8.2 -2.9 0.0 -0.9 0.6 1.0 -1.9
Average weekly fortified wine intake 0.3 0.3 0.9 -0.8 0.0 -0.4 0.3 -0.2 -1.0
Maternal smoking around birth 1.2 1.8 3.7 -1.7 0.0 -1.8 -0.4 0.6 -1.9
Fed-up feelings 0.6 1.2 3.5 -1.4 0.0 -1.9 -0.5 0.9 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 5.6 -2.4 0.0 -0.5 0.4 1.2 -1.9
Relative age voice broke 0.2 0.3 0.6 -0.5 0.0 0.7 -0.1 -0.7 -0.6
Taking other prescription medications 0.5 0.8 3.3 -0.7 0.0 -0.1 -0.5 0.8 -1.8
Age when periods started (menarche) 0.5 1.3 3.5 0.0 0.0 1.2 -1.7 -1.9 0.1
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.6 -0.4 0.0 -1.6 1.6 0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 6.6 2.6 0.0 1.0 1.2 -0.4 2.0
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.6 1.3 0.0 -1.1 1.1 0.7 0.1
Qualifications: CSEs or equivalent 0.3 0.4 2.0 -0.3 0.0 0.4 -1.4 -0.3 -0.1
Serious illness, injury or assault to yourself 0.7 0.8 3.9 -0.4 0.0 -2.0 -0.6 0.0 -0.7
High blood pressure 0.2 0.7 1.6 1.1 0.0 0.9 1.2 0.5 0.7
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.4 0.0 -0.9 -0.1 -0.0 0.5
Multivitamins +/- minerals 0.7 0.9 2.8 -0.9 0.0 -0.0 -0.2 1.7 -1.4
Stomach or abdominal pain in last month 0.4 0.4 1.4 -0.1 0.0 0.2 0.9 -0.6 1.2
Supplements: Glucosamine 1.0 1.3 4.3 1.2 0.0 0.2 1.3 0.6 2.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.6 -0.4 0.0 -1.2 0.4 0.1 -0.2
Medication: Atenolol 0.6 0.7 3.2 0.5 0.0 1.8 0.4 -0.5 0.6
Medication: Levothyroxine sodium 1.0 1.8 6.6 0.5 0.0 -2.6 -0.2 1.5 -1.2
Sitting height 0.6 4.5 11.2 3.4 0.0 2.3 -0.5 -1.3 2.9
Chronic bronchitis/emphysema (father) 1.3 1.5 5.3 1.9 0.0 0.2 -0.4 0.0 2.3
High blood pressure (mother) 0.3 0.4 0.9 0.7 0.0 0.4 -1.0 -0.6 0.7
Body mass index (BMI) 0.2 0.8 3.4 -0.4 0.0 -1.9 -0.3 0.4 -0.9
Impedance of leg (left) 0.1 0.5 2.7 -0.1 0.0 0.4 -1.7 -0.4 0.3
Leg predicted mass (left) 0.1 0.3 0.8 0.9 0.0 0.6 -0.6 -0.6 -0.2
Trunk fat mass 0.1 0.5 2.1 0.1 0.0 -0.4 -1.5 -0.1 -0.7
Waist circumference 0.3 1.1 4.7 0.6 0.0 -2.2 0.2 1.1 -0.3
Number of incorrect matches in round 0.4 0.7 1.8 -1.1 0.0 -0.7 0.2 0.5 -1.4
Past tobacco smoking 1.6 2.9 6.9 1.8 0.0 2.4 1.3 -0.2 2.6
Alcohol usually taken with meals 2.0 3.2 10.8 2.4 0.0 1.3 0.8 -0.9 3.3
Nervous feelings 0.3 0.6 3.3 -0.1 0.0 -1.8 -0.4 0.4 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.7 -1.3 0.0 -1.3 0.9 0.6 -0.1
Hearing difficulty/problems with background noise 0.1 0.2 0.7 0.3 0.0 0.1 -0.8 -0.4 -0.5
Hair/balding pattern: Pattern 2 0.6 0.7 2.8 1.3 0.0 1.7 -0.0 0.2 0.1
Had menopause 0.4 0.5 1.6 0.9 0.0 -0.2 -0.7 -1.3 -0.2
Had other major operations 1.2 1.5 4.8 -1.1 0.0 -2.2 1.4 0.9 0.1
Forced vital capacity (FVC) 0.4 1.4 4.1 1.4 0.0 1.4 0.5 -0.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 3.5 1.8 0.0 1.3 0.2 -0.7 1.9
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 3.0 0.3 0.0 -1.1 -1.7 -1.1 -0.4
Qualifications: None of the above 0.6 1.2 3.5 -0.6 0.0 -0.8 -1.9 -1.3 -1.0
Financial difficulties in last 2 years 1.1 1.5 2.8 -1.3 0.0 -1.6 1.7 1.5 0.3
Mouth/teeth dental problems 0.4 0.6 1.3 0.7 0.0 1.0 1.2 0.7 0.6
Heart attack 0.3 0.4 2.0 -0.0 0.0 -1.4 0.3 -0.2 -0.0
Allergy 0.1 0.2 0.4 -0.0 0.0 0.6 0.5 0.3 -0.6
Pain all over the body in last month 0.2 0.2 0.5 -0.5 0.0 0.6 -0.7 0.6 -0.2
Diabetes (self-reported) 0.2 0.3 0.8 0.7 0.0 0.3 0.4 -0.4 0.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 2.2 1.1 0.0 1.5 -1.4 -1.4 1.3
Medication: Ramipril 0.5 0.6 1.6 1.2 0.0 -1.2 0.2 0.8 0.5
Medication: Simvastatin 0.2 0.3 1.1 -0.0 0.0 -0.4 0.4 -0.1 1.1
Fluid intelligence score 0.2 0.4 1.0 -0.4 0.0 -0.9 0.4 -0.4 -1.0
Illnesses of siblings 0.4 0.6 1.2 -0.5 0.0 0.4 1.0 1.1 -0.9
Neuroticism score 0.4 0.8 2.1 -0.8 0.0 -1.4 -1.4 -0.3 -0.5
Weight 0.1 0.3 0.9 0.8 0.0 -0.4 -0.9 -0.2 -0.1
Impedance of arm (right) 0.2 0.9 2.5 -0.3 0.0 1.5 -1.6 -0.7 0.1
Arm fat percentage (right) 0.2 0.7 1.8 -0.5 0.0 -1.4 -1.3 0.0 -0.8
Trunk fat-free mass 0.1 0.3 0.6 0.8 0.0 0.7 -0.4 -0.6 0.5
Hip circumference 0.2 0.9 3.8 1.0 0.0 0.4 -1.9 -0.7 -0.0
Time employed in main current job 0.3 0.3 0.9 -0.3 0.0 0.6 -0.9 -0.3 -0.6
Alcohol intake versus 10 years previously 0.2 0.3 1.4 -0.1 0.0 -0.3 0.1 -0.1 -1.2
Father’s age at death 0.5 0.6 2.5 0.7 0.0 -0.1 1.6 0.6 0.7
Worrier / anxious feelings 0.2 0.5 2.3 0.2 0.0 -1.5 -0.3 -0.5 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.4 -0.3 0.0 -0.3 1.1 1.2 -0.5
Falls in the last year 0.6 0.9 2.4 -0.9 0.0 -1.2 1.6 0.0 -0.8
Hair/balding pattern: Pattern 3 0.7 1.0 4.3 1.0 0.0 0.2 0.4 -0.8 2.1
Number of live births 0.2 0.3 1.0 -0.3 0.0 -0.5 -1.0 -0.3 0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.2 0.5 0.0 0.8 0.9 0.3 1.5
Pulse rate 0.4 0.6 1.7 -1.3 0.0 0.1 0.7 1.2 0.1
Happiness 1.4 1.7 6.4 -0.9 0.0 -2.5 0.3 1.2 -1.2
Noisy workplace 0.3 0.4 1.0 0.8 0.0 1.0 -0.3 -0.2 0.6
Qualifications: A levels/AS levels or equivalent 0.8 1.8 8.8 -0.4 0.0 -0.3 3.0 1.2 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 3.4 1.1 0.0 1.8 -0.1 -0.9 1.3
Mouth/teeth dental problems: Dentures 0.7 1.1 3.9 -1.4 0.0 -2.0 -0.2 0.7 -0.7
Asthma 0.1 0.2 0.7 0.5 0.0 0.2 -0.8 -0.1 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 -0.4 0.0 0.7 -0.9 0.7 1.0
Medication: Cholesterol lowering 0.2 0.3 0.7 -0.3 0.0 -0.3 0.3 -0.9 0.7
Depression (self-reported) 0.2 0.3 0.8 -0.9 0.0 0.5 0.4 -0.5 -0.4
Medication: Lansoprazole 0.3 0.4 1.5 0.1 0.0 1.2 -0.4 0.4 -0.6
Prospective memory result 0.3 0.4 1.0 1.0 0.0 0.7 -0.6 -0.5 -0.1
Lung cancer (father) 0.5 0.5 2.0 1.0 0.0 -0.2 -0.3 -0.5 1.4
Illnesses of mother 0.3 0.4 1.3 0.2 0.0 1.0 1.2 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.1 0.7 0.0 0.2 1.4 0.2 1.8
Pulse wave Arterial Stiffness index 0.8 0.9 1.8 0.9 0.0 -0.6 0.9 1.3 1.3
Impedance of arm (left) 0.1 0.6 2.1 -0.5 0.0 1.5 -1.1 -0.6 -0.2
Arm fat mass (right) 0.1 0.4 1.3 0.0 0.0 -0.9 -1.1 -0.1 -0.6
Trunk predicted mass 0.1 0.4 0.6 0.7 0.0 0.7 -0.5 -0.8 0.5
Standing height 0.4 3.6 9.2 2.4 0.0 3.0 -1.6 -1.3 1.6
Length of working week for main job 1.1 1.3 2.7 -0.7 0.0 0.9 -1.6 -1.1 -1.6
Exposure to tobacco smoke at home 0.4 0.4 1.2 0.8 0.0 0.1 0.7 -0.4 1.1
Breastfed as a baby 0.2 0.2 0.6 -0.2 0.0 -0.8 0.8 0.1 0.3
Tense / ‘highly strung’ 0.3 0.5 1.2 -1.1 0.0 -0.5 -0.8 0.1 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 4.1 -0.9 0.0 -0.2 -1.1 -2.0 -0.2
Hair/balding pattern: Pattern 4 0.4 0.9 2.5 -0.4 0.0 -1.6 0.6 0.7 -1.3
Birth weight of first child 0.8 1.4 2.9 1.4 0.0 1.7 1.7 0.6 0.6
Peak expiratory flow (PEF) 0.1 0.3 0.7 -0.7 0.0 0.6 -0.2 -0.2 0.9
Pulse wave reflection index 0.2 0.3 1.1 0.6 0.0 -1.1 -0.3 0.2 -0.1
Ever highly irritable/argumentative for 2 days 1.3 1.6 5.6 -2.4 0.0 -1.6 0.5 0.1 -1.0
Loud music exposure frequency 1.2 1.3 4.3 -0.9 0.0 -0.9 -2.1 0.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.8 -0.1 0.0 0.0 2.4 1.2 0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.2 0.9 0.0 -0.5 -1.0 -1.1 0.4
Blood clot in the leg (DVT) 0.4 0.6 1.5 -0.5 0.0 -1.2 0.4 0.1 -1.2
Medication: Paracetamol 0.5 0.8 2.7 -1.6 0.0 0.1 -1.1 -0.4 -0.7
Headache pain in last month 0.1 0.2 0.6 -0.5 0.0 -0.3 0.8 -0.2 0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.8 -1.5 0.0 0.0 0.9 1.6 -1.7
Glaucoma (self-reported) 0.4 0.5 1.3 -0.2 0.0 0.1 -0.8 -1.2 -0.8
Gout (self-reported) 0.4 0.6 2.2 0.1 0.0 1.5 0.8 -0.5 -0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 4.1 -0.4 0.0 -2.0 0.5 1.6 -1.8
Medication: Amlodipine 0.1 0.1 0.3 0.3 0.0 -0.0 0.4 -0.6 -0.5
Medication: Ventolin 100micrograms inhaler 0.6 0.7 3.0 -0.3 0.0 0.8 0.1 1.7 0.8
Birth weight 0.4 0.8 2.9 0.2 0.0 1.7 -0.4 -0.2 -1.3
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.4 1.6 0.0 -0.4 -0.1 -0.4 1.0
High blood pressure (siblings) 0.2 0.3 1.1 -0.7 0.0 -1.0 0.3 0.3 0.1
Forced vital capacity (FVC), Best measure 0.6 2.3 8.0 1.9 0.0 0.9 1.0 -0.5 2.8
Body fat percentage 0.2 0.7 1.7 -0.4 0.0 -1.2 -1.3 0.1 -1.0
Leg fat percentage (right) 0.3 1.2 5.2 -0.6 0.0 -2.3 -0.5 0.8 -0.9
Arm fat-free mass (right) 0.0 0.3 1.2 1.1 0.0 0.4 -0.3 -0.2 0.2
Exposure to tobacco smoke outside home 0.7 0.9 1.9 -1.1 0.0 -1.4 0.2 1.2 -0.8
Comparative body size at age 10 0.3 0.9 2.0 -0.7 0.0 1.1 -1.2 -1.4 -0.5
Number of full brothers 0.9 1.1 2.5 -0.2 0.0 -1.6 -1.1 -0.9 -1.4
Worry too long after embarrassment 0.2 0.4 1.4 0.1 0.0 -0.3 -1.2 0.2 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.8 -1.3 0.0 -1.3 0.9 0.7 -1.3
Wheeze or whistling in the chest in last year 0.1 0.3 0.8 0.8 0.0 -0.1 -0.9 -0.5 -0.2
Number of children fathered 0.6 0.7 1.5 0.8 0.0 0.8 0.1 -1.2 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.8 1.3 0.0 0.3 -0.6 -0.6 0.7
Age at first live birth 1.2 2.1 5.5 -0.2 0.0 -1.3 2.4 2.3 0.4
Pulse wave peak to peak time 0.7 0.8 1.5 -0.8 0.0 0.7 -0.9 -1.1 -1.2
Health satisfaction 1.7 2.2 4.3 -2.0 0.0 -1.4 -1.0 1.4 -2.1
Shortness of breath walking on level ground 1.3 1.5 4.4 -1.1 0.0 -2.1 -0.2 1.3 -1.3
Qualifications: College or University degree 0.4 1.3 3.2 1.1 0.0 0.3 1.8 1.0 1.4
Eye problems/disorders: None of the above 1.0 1.1 3.9 0.3 0.0 -0.7 1.4 2.0 0.7
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.0 -0.5 0.0 0.2 -1.0 -0.3 -0.2
Emphysema/chronic bronchitis 0.6 0.7 1.9 0.0 0.0 1.4 -1.2 -0.9 -0.3
Medication for pain relief, constipation, heartburn 0.1 0.1 0.2 0.5 0.0 -0.3 0.4 0.4 -0.3
Neck or shoulder pain in last month 1.1 1.6 3.3 -1.7 0.0 -0.0 -1.6 -0.8 -1.8
Medication: Blood pressure 1.6 2.9 5.7 2.4 0.0 1.4 -2.0 -1.9 1.4
Angina (self-reported) 0.7 0.9 4.4 1.0 0.0 -2.1 -0.4 -0.1 0.2
Migraine (self-reported) 0.6 0.8 2.4 -1.5 0.0 -0.3 -0.3 -0.1 -1.4
Medication: Ibuprofen 0.7 0.8 1.7 -1.3 0.0 0.4 -1.2 1.2 0.5
Medication: Allopurinol 0.3 0.4 1.3 0.7 0.0 1.1 0.2 0.6 0.1
Medication: Omeprazole 0.4 0.4 1.3 -1.2 0.0 -0.7 -0.1 -0.0 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.7 0.0 -0.8 0.5 0.4 -0.0
Mean time to correctly identify matches 0.1 0.1 0.5 0.4 0.0 -0.4 0.7 -0.1 0.0
Heart disease (mother) 0.1 0.2 0.4 0.2 0.0 -0.7 0.2 -0.5 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.2 0.9 0.0 0.1 1.2 0.8 1.5
Whole body fat mass 0.1 0.6 1.7 -0.2 0.0 -0.8 -1.3 -0.0 -1.0
Leg fat mass (right) 0.2 0.9 2.9 0.1 0.0 -1.7 -1.1 0.3 -1.0
Arm predicted mass (right) 0.0 0.1 0.5 0.7 0.0 0.1 -0.1 -0.0 0.1
Pulse rate, automated reading 0.7 2.2 6.4 0.8 0.0 -1.0 1.9 2.5 1.4
Alcohol intake frequency. 0.0 0.1 0.3 0.1 0.0 -0.1 0.6 0.1 -0.3
Comparative height size at age 10 0.2 0.9 2.5 1.0 0.0 0.6 -0.0 1.2 1.6
Number of full sisters 0.2 0.2 0.8 -0.6 0.0 0.1 -0.3 -0.1 -0.9
Suffer from ‘nerves’ 0.1 0.1 0.4 -0.6 0.0 -0.2 -0.6 -0.2 -0.2
Overall health rating 0.3 0.6 2.0 -0.4 0.0 -0.3 -1.0 0.4 -1.4
Chest pain or discomfort 0.2 0.2 0.6 -0.6 0.0 -0.1 -0.7 -0.8 -0.1
Had major operations 0.6 0.7 2.1 0.8 0.0 0.6 -1.4 -1.1 0.2
Age at last live birth 0.6 0.9 2.5 -1.1 0.0 -1.0 0.8 1.6 -0.4
Family relationship satisfaction 1.2 1.4 4.6 -1.4 0.0 -2.1 0.8 1.0 -0.7
Leg pain on walking 0.8 1.0 1.9 -0.7 0.0 -1.4 1.3 1.3 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.4 -0.3 0.0 0.5 -0.3 -0.5 -1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.5 0.8 0.0 1.6 -1.0 -0.4 0.5
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.2 1.1 0.0 1.5 -0.1 -1.4 1.3
Medication: Aspirin 0.2 0.3 0.9 0.1 0.0 -0.9 1.0 0.3 -0.0
Supplements: Vitamin C 0.7 0.8 2.7 1.3 0.0 0.3 -0.3 -0.6 1.6
Knee pain experienced in last month 0.5 0.8 2.2 -1.0 0.0 -1.1 0.3 0.5 -1.5
Hypertension (Self-reported) 0.3 0.8 1.7 1.3 0.0 0.8 1.3 0.7 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 0.4 0.0 0.6 -0.5 0.2 0.3
Illnesses of father: Heart disease 0.7 1.0 3.0 1.7 0.0 0.8 0.2 -0.6 1.5
Illnesses of siblings: Diabetes 1.4 1.7 3.7 1.5 0.0 0.9 -1.2 -1.4 1.9
Smoking status: Previous 0.8 1.2 3.1 -0.5 0.0 -1.3 -1.8 -0.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.4 -0.3 0.0 1.8 -0.8 -0.8 -0.3
Whole body fat-free mass 0.0 0.3 0.7 0.8 0.0 0.6 -0.5 -0.6 0.2
Leg fat-free mass (right) 0.1 0.3 1.0 1.0 0.0 0.7 -0.6 -0.5 0.2
Arm fat percentage (left) 0.2 1.0 2.2 -0.9 0.0 -1.5 -1.0 0.3 -1.3
Average weekly red wine intake 0.6 0.9 2.1 1.1 0.0 0.7 0.4 -1.3 1.5
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.6 0.0 0.0 1.3 0.9 0.7 1.6
Mood swings 0.4 0.8 2.5 0.8 0.0 -1.6 -0.6 -1.2 0.2
Loneliness, isolation 1.2 1.7 5.2 -1.5 0.0 -1.2 0.1 1.2 -2.3
Long-standing illness, disability or infirmity 0.3 0.5 1.3 -0.7 0.0 -0.5 -0.6 0.7 -1.1
Ever had bowel cancer screening 0.2 0.3 0.9 0.4 0.0 0.5 -0.3 -1.0 0.3
Diabetes diagnosed by doctor 0.1 0.1 0.3 0.3 0.0 0.2 0.3 -0.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.7 -1.5 0.0 1.4 -1.3 -1.6 -0.7
Friendships satisfaction 0.8 1.0 2.8 1.2 0.0 -1.7 -0.8 0.8 0.6
Qualifications: nursing, teaching 0.4 0.6 2.3 -0.3 0.0 1.5 1.0 0.1 -0.2
Commuting to job workplace: Walk 0.6 0.7 1.8 -0.7 0.0 -1.4 0.5 1.2 0.1
Eye problems/disorders: Cataract 0.6 0.7 1.6 -0.5 0.0 0.6 -1.3 -0.7 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 3.4 0.7 0.0 1.8 -0.2 -0.3 1.0
Medication for cholesterol 0.9 1.3 3.2 -1.3 0.0 0.6 -1.8 -1.7 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 8.2 0.7 0.0 0.7 -2.9 -1.5 -0.2
Back pain experienced in last month 0.4 0.6 1.8 -0.9 0.0 -0.4 0.2 0.9 -1.4
Mineral and other dietary supplements 0.8 1.1 4.8 0.6 0.0 0.6 -1.1 -2.2 0.3
Breast cancer (self-reported) 0.4 0.5 2.0 -0.3 0.0 -1.4 0.3 0.6 -0.7
Asthma (self-reported) 0.0 0.1 0.4 0.4 0.0 -0.2 -0.6 0.0 0.1
Osteoporosis (self-reported) 1.1 1.4 3.2 -1.2 0.0 -1.8 -0.9 -0.1 -1.7
Osteoarthritis (self-reported) 0.2 0.2 0.4 0.3 0.0 0.6 -0.6 0.2 0.6
Medication: Aspirin 0.0 0.0 0.1 -0.0 0.0 -0.2 0.3 0.0 -0.3
Medication: Gliclazide 0.5 0.6 1.3 1.1 0.0 -1.1 1.0 0.1 -0.5
Illnesses of father: None of the above (group 1) 2.2 2.7 7.6 -2.4 0.0 -1.7 -0.1 0.4 -2.8
Smoking status: Current 1.4 2.2 7.5 -2.7 0.0 -0.8 0.7 1.2 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 7.5 0.7 0.0 0.4 1.5 -0.6 2.7
Whole body water mass 0.0 0.2 0.7 0.8 0.0 0.5 -0.4 -0.4 0.3
Leg predicted mass (right) 0.1 0.3 0.8 0.9 0.0 0.6 -0.5 -0.4 0.1
Arm fat mass (left) 0.1 0.5 1.0 -0.3 0.0 -1.0 -1.0 0.1 -0.8
Number of self-reported non-cancer illnesses 0.2 0.3 1.1 0.4 0.0 0.4 -0.7 -1.0 -0.1
Average weekly champagne plus white wine intake 0.3 0.5 1.7 0.4 0.0 0.5 -0.3 -1.3 0.8
Miserableness 1.1 1.9 5.9 -1.5 0.0 -2.4 -0.8 -0.2 -1.7
Guilty feelings 0.6 0.8 2.9 -0.5 0.0 -1.7 0.5 1.1 -0.6
Wears glasses or contact lenses 0.2 0.3 1.0 1.0 0.0 -0.1 -0.5 -0.2 0.7
Ever taken oral contraceptive pill 0.6 0.7 2.3 0.2 0.0 1.3 -0.3 -1.5 0.1
Hearing aid user 0.9 1.0 2.9 1.7 0.0 -0.6 0.7 0.1 1.5
Mother’s age at death 1.3 1.6 4.9 0.6 0.0 0.6 -1.9 -2.2 -0.2
Financial situation satisfaction 0.6 0.7 1.7 -1.3 0.0 -1.1 -0.2 1.1 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.0 -0.2 0.0 0.4 -0.9 -1.4 -0.1
Commuting to job workplace: Public transport 0.5 0.6 1.9 1.0 0.0 -0.4 0.7 -0.6 1.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.0 0.9 0.0 0.6 -1.2 -1.4 -0.2
Medication: Blood pressure 0.4 0.8 1.3 1.1 0.0 -1.2 1.1 0.9 -0.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.0 0.0 0.2 -0.3 0.6 -0.2
Supplements: Fish oil (including cod liver oil) 1.2 1.6 4.3 -1.5 0.0 -0.8 1.4 2.1 -0.5
High cholesterol (Self-reported) 0.4 0.7 2.4 1.0 0.0 0.4 0.9 0.2 1.6
Medication: Bendroflumethiazide 0.9 1.3 3.3 1.8 0.0 1.1 -0.8 -1.6 -0.0
Medication: Paracetamol 0.5 0.8 3.8 -1.9 0.0 -0.7 -0.4 0.6 -0.1
Medication: Lisinopril 0.2 0.2 1.0 -0.2 0.0 -0.1 -1.0 -0.6 0.2
Medication: Atorvastatin 1.0 1.3 3.7 1.9 0.0 0.5 -1.3 -1.2 0.8
Illnesses of father: High blood pressure 1.0 1.2 4.7 0.7 0.0 0.1 2.2 1.3 0.7
Alcohol drinker status: Never 0.6 0.7 1.6 0.1 0.0 1.1 -1.1 -1.3 0.6
Ever smoked 2.2 3.8 9.5 -2.5 0.0 -2.5 -0.2 0.9 -3.1
Basal metabolic rate 0.1 0.3 0.8 0.9 0.0 0.4 -0.7 -0.5 0.2
Leg fat percentage (left) 0.3 1.0 4.7 -0.2 0.0 -2.2 -0.6 0.9 -0.5
Arm fat-free mass (left) 0.1 0.4 1.3 1.2 0.0 0.2 -0.6 -0.5 0.6
Number of operations (self-reported) 0.1 0.2 0.8 0.3 0.0 -0.9 -0.0 0.2 0.3
Average weekly beer plus cider intake 0.3 0.4 0.9 -0.8 0.0 -1.0 0.6 0.4 -0.5
Irritability 1.3 2.3 4.8 -1.5 0.0 -2.2 1.2 1.0 -2.0
Risk taking 0.2 0.2 0.5 -0.7 0.0 0.6 -0.1 0.2 -0.7
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.7 0.2 0.0 0.7 -0.3 -0.8 0.5
Fractured/broken bones in last 5 years 0.6 0.7 2.3 -0.3 0.0 -1.5 1.1 0.6 -0.5
Age started oral contraceptive pill 2.0 2.5 6.1 -0.5 0.0 -2.2 1.5 2.5 -1.1
Diastolic blood pressure, automated reading 0.6 1.8 4.5 0.6 0.0 -1.6 1.6 2.1 -0.7
Ever depressed for a whole week 0.5 0.6 1.8 -0.6 0.0 -1.4 0.6 0.2 -1.0
Unable to work because of sickness or disability 2.3 3.0 7.1 -2.5 0.0 -1.1 0.4 1.7 -2.7
Commuting to job workplace: Cycle 1.3 1.6 7.6 -0.2 0.0 0.3 2.8 1.1 0.6
Myopia 1.3 1.8 4.0 -1.7 0.0 -2.0 -0.2 0.8 -1.9
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.4 -0.9 0.0 -0.1 -1.2 -0.7 -0.8
Cholesterol lowering medication 0.9 1.4 3.1 1.8 0.0 -1.2 0.9 0.9 1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.6 -1.2 0.0 -1.3 1.1 0.9 -0.7
Pain experienced in last month 1.3 2.1 7.2 1.9 0.0 1.3 0.3 -0.5 2.7
Supplements: Calcium 3.6 4.0 8.1 -2.2 0.0 -2.8 1.4 2.5 -1.7
Basal cell carcinoma (self-reported) 0.5 0.6 1.3 1.0 0.0 0.2 1.1 0.3 1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.9 0.1 0.0 -1.4 0.4 -0.1 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.2 -0.3 0.0 -0.9 -0.1 -0.3 -1.1
Heart disease (siblings) 1.0 1.2 2.3 0.7 0.0 -1.5 -1.4 -1.5 -0.7
Alcohol drinker status: Previous 1.2 1.4 4.5 -0.3 0.0 -2.1 0.7 1.8 -0.1
Pack years of smoking 0.5 0.7 2.3 0.9 0.0 -1.5 0.0 1.0 0.3
Impedance of whole body 0.2 0.8 2.3 -0.2 0.0 1.5 -1.5 -0.5 0.2
Leg fat mass (left) 0.2 0.8 2.5 0.3 0.0 -1.6 -1.2 0.4 -0.7
Arm predicted mass (left) 0.1 0.3 1.1 1.1 0.0 -0.1 -0.6 -0.2 0.6