TWAS hub - CD3EAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.077	0.027	3.2e-04	0.077	0.039	0.057	0.06	0.071	1.3e-09	1.4e-05	1.7e-07	7.1e-08	5.2e-09
2	TCGA	Thyroid Carcinoma	0.093	0.037	1.7e-05	0.051	0.051	0.031	NA	0.035	9.8e-06	9.0e-06	4.9e-04	NA	2.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Atorvastatin	4.3	5.4	9.1	1.3	3.0
Supplements: Fish oil (including cod liver oil)	4.0	5.2	6.4	-2.5	-2.0
Illnesses of mother	3.1	3.8	4.7	-2.2	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	4.3	-2.1	-1.9
Frequency of depressed mood in last 2 weeks	2.8	3.9	5.1	-1.7	-2.3
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	3.9	-1.5	2.0
Breastfed as a baby	2.6	3.2	5.9	-2.4	0.7
Blood Platelet Count	2.5	29.5	57.9	7.6	1.0
Number of children fathered	2.3	2.6	5.0	2.2	0.3
Knee pain experienced in last month	2.3	3.6	7.2	-2.7	-0.2
Sensitivity / hurt feelings	2.1	3.5	6.1	-1.0	-2.5
Medication: Ramipril	2.1	2.8	3.5	1.9	1.4
Health satisfaction	2.1	2.7	3.4	-1.4	-1.8
High cholesterol (Self-reported)	2.1	3.8	6.4	2.5	1.1
Chronotype (morning person)	2.0	4.6	6.6	1.6	2.6
Medication: Co-codamol	2.0	2.4	3.0	1.3	1.7
Medication: Atenolol	2.0	2.5	3.0	1.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.9	-2.4	0.6
Nervous feelings	1.9	3.6	4.9	-2.2	-1.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	2.8	1.7	1.3
Basal cell carcinoma (self-reported)	1.9	2.2	2.3	-1.5	-1.5
Diabetes (mother)	1.8	2.3	4.6	-2.1	0.1
Medication: Paracetamol	1.8	2.9	5.4	2.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.6	1.9	0.8
Depression (Nagel 2018)	1.7	2.6	3.8	-1.2	-1.9
LDL Cholesterol	1.7	2.7	4.2	2.1	1.0
Heel T-Score	1.7	13.1	14.7	3.8	3.4
Friendships satisfaction	1.7	2.1	2.8	-1.7	-1.2
Alzheimer’s Disease (including proxy)	1.6	2.3	3.0	1.7	1.3
Body Mass Index (BMI) (2010)	1.6	2.2	3.9	2.0	0.6
Had major operations	1.6	1.9	3.7	0.2	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	2.9	-1.0	-1.7
Smoking status: Previous	1.6	2.4	4.3	2.1	0.8
Loneliness, isolation	1.6	2.2	3.3	-1.8	-1.1
Loud music exposure frequency	1.5	1.6	2.2	1.0	1.5
Fractured/broken bones in last 5 years	1.5	1.9	3.3	-1.8	-0.7
Mean Putamen Volume	1.4	1.6	2.4	-0.9	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	4.6	2.1	1.3
Pain all over the body in last month	1.4	1.5	1.6	1.2	1.3
Eye problems/disorders: None of the above	1.4	1.6	2.4	0.9	1.6
Supplements: Vitamin C	1.4	1.7	3.4	-1.8	-0.1
Number of self-reported non-cancer illnesses	1.4	2.4	4.0	0.9	2.0
Alzheimer’s Disease (in mother)	1.3	1.5	2.0	1.4	1.0
Cardiovascular Disease	1.3	4.2	4.3	2.0	2.1
Neuroticism	1.3	3.1	6.2	-0.2	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	4.0	1.5	2.0
Eye problems/disorders: Cataract	1.3	1.5	3.0	0.0	-1.7
Cholesterol lowering medication	1.3	2.0	2.5	1.6	1.2
Depressed Affect (Nagel 2018)	1.2	2.4	4.3	-0.7	-2.1
Severe depression (siblings)	1.2	1.4	1.6	-1.2	-1.1
Townsend deprivation index at recruitment	1.2	1.8	3.3	-1.8	0.4
Worrier / anxious feelings	1.2	2.2	4.4	-0.1	-2.1
Glaucoma (self-reported)	1.2	1.4	2.5	-1.6	-0.5
Medication for pain relief, constipation, heartburn	1.2	2.1	3.9	-2.0	-0.6
Medication for cholesterol	1.2	1.9	1.9	-1.3	-1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	-0.2	1.7
Irritability	1.2	2.0	3.8	-0.4	-2.0
Unable to work because of sickness or disability	1.2	1.6	3.0	-1.7	0.4
Bipolar Disorder (2018)	1.1	1.8	3.4	0.4	1.8
Bipolar Disorder or Schizophrenia	1.1	2.7	5.4	-0.0	2.3
Neuroticism (Nagel 2018)	1.1	2.5	5.0	-0.2	-2.2
Heart attack	1.1	1.4	1.8	1.0	1.3
Emphysema/chronic bronchitis	1.1	1.2	2.0	-1.4	-0.7
Migraine (self-reported)	1.1	1.4	1.6	1.1	1.3
Illnesses of father: Heart disease	1.1	1.6	3.1	-0.1	-1.8
Medication: Paracetamol	1.1	1.7	3.2	1.8	0.4
Lupus	1.0	1.6	3.0	-1.7	-0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.1	1.4	0.4
High blood pressure (mother)	1.0	1.4	2.7	1.6	0.1
Neuroticism score	1.0	2.1	3.5	-0.9	-1.9
Impedance of arm (right)	1.0	4.7	6.9	-2.6	1.6
Falls in the last year	1.0	1.4	2.6	-1.6	-0.4
Happiness	1.0	1.2	1.4	-1.2	-1.0
Medication: Allopurinol	1.0	1.3	2.5	1.6	0.1
Medication: Seretide 50 evohaler	1.0	1.1	2.2	0.2	1.5
Chest pain or discomfort	1.0	1.4	2.3	-0.7	1.5
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.6	1.3	0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	0.4	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.4	1.2	-0.8
Risk taking	1.0	1.5	2.5	-1.6	-0.7
Supplements: Calcium	1.0	1.1	2.1	-1.5	-0.1
Alcohol drinker status: Previous	1.0	1.1	1.8	-1.4	0.6
Breast Cancer	0.9	2.1	3.0	1.1	1.7
Age at First Birth	0.9	1.3	2.1	-0.8	-1.5
HbA1C	0.9	1.0	1.8	-1.3	0.5
Neuroticism (2016)	0.9	1.2	1.8	-0.8	-1.4
Rheumatoid Arthritis	0.9	1.2	1.3	-1.1	-1.1
Serious illness, injury or assault to yourself	0.9	1.1	2.0	-1.4	0.5
Supplements: Glucosamine	0.9	1.2	2.0	-1.4	0.5
Alcohol usually taken with meals	0.9	1.5	1.6	1.3	1.2
Gout (self-reported)	0.9	1.2	1.5	1.2	1.0
Comparative body size at age 10	0.9	2.5	5.0	2.2	-0.1
Heart disease (mother)	0.9	1.1	1.2	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.2	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.6	-0.4	-1.6
Osteoarthritis (self-reported)	0.9	1.1	2.2	-1.5	0.1
Average weekly champagne plus white wine intake	0.9	1.2	2.0	0.6	1.4
Miserableness	0.9	1.6	3.1	-0.3	-1.8
Medication: Blood pressure	0.9	1.8	2.0	1.3	1.4
Average weekly beer plus cider intake	0.9	1.4	2.6	0.4	-1.6
Ever depressed for a whole week	0.9	1.1	2.0	-1.4	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.3	1.1	1.1
Hand grip strength (left)	0.8	2.0	3.9	2.0	0.3
Vitamin and mineral supplements	0.8	1.1	1.4	1.2	0.9
Fed-up feelings	0.8	1.5	1.6	-1.3	-1.2
Relative age voice broke	0.8	1.2	1.4	-1.2	1.0
Tense / ‘highly strung’	0.8	1.4	1.6	-1.3	-1.0
Number of full brothers	0.8	1.0	1.9	-0.3	1.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.4	1.2	0.7
Eye problems/disorders: Glaucoma	0.8	1.0	2.0	-1.4	-0.1
Myopia	0.8	1.2	2.0	1.4	0.6
Blood Eosinophil Count	0.7	5.7	7.5	-2.0	2.7
Time employed in main current job	0.7	0.8	1.7	1.3	0.1
Medication: Lansoprazole	0.7	0.8	1.4	0.4	1.2
Exposure to tobacco smoke outside home	0.7	0.9	1.9	-1.4	0.0
Worry too long after embarrassment	0.7	1.1	1.6	0.8	-1.2
Leg fat mass (right)	0.7	2.8	3.2	1.8	1.5
Pulse rate, automated reading	0.7	2.3	2.5	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	1.7	1.0	1.3
Mineral and other dietary supplements	0.7	1.0	1.6	1.3	0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.7	0.2	1.9
Schizophrenia (2018)	0.6	1.2	2.2	-0.3	1.5
HDL Cholesterol	0.6	1.0	2.0	0.0	1.4
Blood Red Count	0.6	5.7	5.7	-2.4	-2.4
Waist Hip Ratio (WHR)	0.6	2.5	3.5	1.2	1.9
Past tobacco smoking	0.6	1.2	2.1	-1.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	-0.4	-1.3
Mouth/teeth dental problems	0.6	0.8	1.7	1.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.1	0.8	1.5
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	-1.4	0.2
Medication: Cholesterol lowering	0.6	1.0	1.6	0.6	1.3
Impedance of arm (left)	0.6	2.8	4.5	-2.1	1.1
Length of working week for main job	0.6	0.6	1.3	-1.1	-0.1
Exposure to tobacco smoke at home	0.6	0.7	1.2	-1.1	-0.5
Leg fat percentage (right)	0.6	2.3	2.5	1.6	1.5
Family relationship satisfaction	0.6	0.8	1.0	-1.0	-0.7
Average weekly red wine intake	0.6	0.8	0.9	1.0	0.8
Wears glasses or contact lenses	0.6	0.6	0.7	-0.8	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.2	-1.5	-1.0
Pack years of smoking	0.6	0.8	1.3	-0.6	1.1
Leg fat mass (left)	0.6	2.5	2.9	1.7	1.4
Prostate Cancer	0.5	0.7	1.3	-1.1	-0.3
Schizophrenia (2014)	0.5	1.2	1.8	-0.8	1.3
Respiratory disease	0.5	1.2	1.3	-1.1	1.1
Number of treatments/medications taken	0.5	0.9	1.4	1.2	0.6
Relative age of first facial hair	0.5	1.1	2.0	-1.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.1	1.0
Pack years adult smoking proportion	0.5	0.7	1.3	-0.5	1.1
Had other major operations	0.5	0.7	0.9	-1.0	-0.6
Financial difficulties in last 2 years	0.5	0.7	1.4	0.0	-1.2
Medication: Simvastatin	0.5	0.7	1.1	1.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-0.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-1.1	0.1
Medication: Blood pressure	0.5	0.9	1.3	0.7	1.1
Arm predicted mass (right)	0.5	2.4	4.8	2.2	-0.2
Alcohol intake frequency.	0.5	1.2	1.7	-1.3	-0.9
Illnesses of father: High blood pressure	0.5	0.7	1.1	1.1	0.5
Alcohol drinker status: Never	0.5	0.6	0.6	0.7	-0.8
Leg fat percentage (left)	0.5	1.9	2.3	1.5	1.2
Arm predicted mass (left)	0.5	2.4	4.8	2.2	0.2
Worry (Nagel 2018)	0.4	0.8	1.3	-0.6	-1.1
Crohns Disease (2017)	0.4	0.8	1.2	0.6	1.1
Reaction Time	0.4	0.7	0.8	0.8	-0.9
Smoking Status	0.4	1.0	1.9	1.4	0.4
Hypothyroidism (self reported)	0.4	0.8	1.4	-0.5	-1.2
Lung FEV1/FVC ratio	0.4	1.8	3.0	1.7	0.9
Average weekly spirits intake	0.4	0.6	0.7	-0.9	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.1	1.0
Diabetes (father)	0.4	0.4	0.8	-0.3	0.9
Hand grip strength (right)	0.4	1.1	1.9	1.4	0.6
Age when periods started (menarche)	0.4	1.1	1.9	-1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	-0.5	0.7
Chronic bronchitis/emphysema (father)	0.4	0.4	0.5	-0.7	-0.6
Allergy	0.4	1.0	1.6	1.3	-0.6
Arm fat percentage (right)	0.4	1.5	3.0	0.2	1.7
Hip circumference	0.4	1.7	2.2	1.5	1.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	1.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.9	-0.5	-1.0
Birth weight	0.4	0.8	1.0	-0.8	1.0
Arm fat-free mass (right)	0.4	2.2	4.3	2.1	-0.2
Medication: Aspirin	0.4	0.5	0.5	-0.7	0.7
Commuting to job workplace: Walk	0.4	0.4	0.6	0.5	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	-0.1	1.2
Arm fat mass (left)	0.4	1.7	1.8	1.2	1.4
Arm fat-free mass (left)	0.4	2.0	4.1	2.0	0.0
Number of operations (self-reported)	0.4	0.6	0.8	0.9	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	0.9	-0.4
Pain experienced in last month	0.4	0.6	0.8	0.9	0.6
Irritable Bowel Disease (IBD)	0.3	0.7	0.9	0.7	0.9
Systolic Blood Pressure	0.3	1.7	2.3	1.1	1.5
Allergy or Eczema	0.3	0.7	1.0	-0.6	1.0
Lung FVC	0.3	1.3	1.5	-1.2	-1.1
Maternal smoking around birth	0.3	0.4	0.5	0.7	0.6
High blood pressure	0.3	0.8	1.0	1.0	0.7
Medication: Levothyroxine sodium	0.3	0.6	1.0	-0.4	-1.0
Waist circumference	0.3	1.0	1.1	1.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.4	-0.5	-0.6
Weight	0.3	1.7	2.7	1.6	0.8
Trunk fat-free mass	0.3	1.8	3.6	1.9	0.1
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.3	-0.9
Noisy workplace	0.3	0.4	0.5	0.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.5	0.8
Depression (self-reported)	0.3	0.3	0.3	-0.6	-0.6
Prospective memory result	0.3	0.3	0.5	0.7	0.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	0.5	-0.6
Arm fat mass (right)	0.3	1.1	1.4	0.9	1.2
Trunk predicted mass	0.3	1.8	3.5	1.9	0.1
Birth weight of first child	0.3	0.6	1.2	-1.1	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	-0.7	0.5
Headache pain in last month	0.3	0.6	0.8	0.5	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	0.4	0.8
High blood pressure (siblings)	0.3	0.4	0.4	-0.6	0.6
Body fat percentage	0.3	1.2	2.1	0.5	1.5
Whole body fat mass	0.3	1.2	1.7	0.8	1.3
Number of full sisters	0.3	0.3	0.5	-0.3	0.7
Suffer from ‘nerves’	0.3	0.5	0.6	-0.8	0.7
Illnesses of siblings: Diabetes	0.3	0.3	0.6	-0.3	0.8
Arm fat percentage (left)	0.3	1.3	2.4	0.4	1.6
Long-standing illness, disability or infirmity	0.3	0.5	0.6	-0.7	-0.8
Ever had bowel cancer screening	0.3	0.4	0.4	-0.5	0.7
Qualifications: nursing, teaching	0.3	0.4	0.7	-0.4	0.8
Breast cancer (self-reported)	0.3	0.4	0.7	0.3	-0.9
Basal metabolic rate	0.3	1.6	2.9	1.7	0.4
Diastolic blood pressure, automated reading	0.3	0.8	1.6	-0.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.4	-0.6	0.6
Impedance of whole body	0.3	1.8	2.3	-1.5	1.1
Alzheimer’s Disease (in father)	0.2	0.3	0.5	-0.1	0.7
Major Depression (MDD)	0.2	0.2	0.4	0.6	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	0.2	1.0
Triglycerides	0.2	0.4	0.6	-0.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.0	0.7
Ulcerative Colitis	0.2	0.3	0.3	0.6	0.5
Height	0.2	3.8	5.0	2.2	1.6
Hair Pigment	0.2	4.9	8.9	-3.0	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.6	-0.0
Angina	0.2	0.3	0.6	0.8	0.1
Impedance of leg (right)	0.2	1.1	2.1	0.3	1.4
Trunk fat percentage	0.2	0.9	1.8	0.0	1.3
Current tobacco smoking	0.2	0.4	0.7	-0.9	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	0.6
Multivitamins +/- minerals	0.2	0.3	0.5	-0.7	0.0
Body mass index (BMI)	0.2	0.9	1.6	1.3	0.4
Trunk fat mass	0.2	0.9	1.6	0.6	1.2
Fluid intelligence score	0.2	0.5	0.5	0.7	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.3	-0.5	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.3	-0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	-0.4	-0.8
Pulse wave peak to peak time	0.2	0.2	0.3	-0.3	0.5
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.4	-0.5
Qualifications: College or University degree	0.2	0.5	0.9	-0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.2	0.7
Leg pain on walking	0.2	0.3	0.3	-0.5	-0.6
Hypertension (Self-reported)	0.2	0.6	0.7	0.7	0.8
Whole body fat-free mass	0.2	1.2	2.3	1.5	0.1
Back pain experienced in last month	0.2	0.2	0.5	-0.7	-0.2
Asthma (self-reported)	0.2	0.4	0.6	-0.8	0.4
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.1	-0.6
Medication: Aspirin	0.2	0.2	0.4	-0.2	0.6
Smoking status: Current	0.2	0.3	0.6	-0.8	0.1
Whole body water mass	0.2	1.3	2.6	1.6	0.1
Guilty feelings	0.2	0.3	0.3	0.5	-0.6
Hearing aid user	0.2	0.2	0.3	-0.6	-0.2
Mother’s age at death	0.2	0.2	0.4	-0.0	-0.7
Financial situation satisfaction	0.2	0.2	0.5	-0.1	-0.7
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.7	-0.3
Age started oral contraceptive pill	0.2	0.3	0.4	-0.4	0.6
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.0	0.4
Ovarian Cancer	0.1	0.1	0.2	-0.5	0.3
Crohns Disease (2012)	0.1	0.1	0.2	0.5	0.1
Fasting Glucose	0.1	0.1	0.3	0.5	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.5	0.3
Blood White Count	0.1	0.6	1.1	1.1	0.1
BMI	0.1	0.5	0.9	0.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.2
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.3	-0.5
Supplements: Zinc	0.1	0.1	0.1	-0.2	0.3
Medication: Metformin	0.1	0.2	0.4	-0.6	-0.2
Leg fat-free mass (left)	0.1	0.5	0.8	0.9	0.5
Average weekly fortified wine intake	0.1	0.2	0.3	-0.5	0.1
Taking other prescription medications	0.1	0.1	0.1	0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.3	-0.5
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.2	-0.3
Sitting height	0.1	1.0	2.1	0.0	1.4
Impedance of leg (left)	0.1	0.5	0.9	0.2	0.9
Leg predicted mass (left)	0.1	0.5	0.8	0.9	0.4
Number of incorrect matches in round	0.1	0.1	0.1	-0.3	0.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.2	0.6
Had menopause	0.1	0.2	0.2	-0.5	0.3
Forced vital capacity (FVC)	0.1	0.5	0.7	-0.6	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.2	0.5
Illnesses of siblings	0.1	0.1	0.3	0.1	-0.5
Father’s age at death	0.1	0.2	0.3	0.6	0.2
Number of live births	0.1	0.1	0.1	0.3	-0.3
Pulse rate	0.1	0.1	0.2	0.2	-0.5
Asthma	0.1	0.3	0.4	-0.4	0.6
Lung cancer (father)	0.1	0.1	0.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.5	0.2
Standing height	0.1	0.8	0.8	0.9	0.9
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.0	0.6
Pulse wave reflection index	0.1	0.2	0.3	0.5	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	0.5
Medication: Amlodipine	0.1	0.1	0.1	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.5	0.2
Angina (self-reported)	0.1	0.2	0.3	0.5	0.1
Medication: Omeprazole	0.1	0.1	0.2	-0.2	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	-0.2	-0.6
Comparative height size at age 10	0.1	0.6	1.1	1.0	-0.2
Overall health rating	0.1	0.3	0.4	-0.6	-0.4
Age at last live birth	0.1	0.2	0.3	0.6	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.5
Mood swings	0.1	0.2	0.3	0.0	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.4	0.1
Medication: Gliclazide	0.1	0.1	0.1	0.4	0.4
Medication: Bendroflumethiazide	0.1	0.2	0.2	-0.4	0.5
Medication: Lisinopril	0.1	0.2	0.3	0.2	0.6
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.0	0.6
Heart disease (siblings)	0.1	0.1	0.1	-0.3	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.1	0.0
Tanning	0.0	0.3	0.4	0.4	0.6
Medication for hormone replacement therapy	0.0	0.0	0.1	0.3	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.3	0.2
Qualifications: None of the above	0.0	0.1	0.1	-0.4	0.1
Diabetes (self-reported)	0.0	0.1	0.1	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.0	0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.1	0.3
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.2	0.3
Age at first live birth	0.0	0.1	0.2	0.4	-0.0
Neck or shoulder pain in last month	0.0	0.0	0.0	0.0	0.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	0.2
Leg fat-free mass (right)	0.0	0.3	0.5	0.7	0.1
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.0
Leg predicted mass (right)	0.0	0.3	0.5	0.7	0.1
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.0	-0.2
Ever smoked	0.0	0.1	0.1	-0.3	0.2

Hub : Genes

CD3EAP

Models

Trait associations