TWAS hub - CDC25B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2270	0.0460	1.6e-08	0.124	0.117	0.181	0.177	0.171	7.3e-15	4.4e-14	1.5e-21	4.5e-21	2.7e-20
2	GTEx	Adipose Subcutaneous	0.1640	0.0500	3.8e-04	0.132	NA	0.108	NA	0.110	6.3e-11	NA	4.1e-09	NA	2.8e-09
3	GTEx	Adipose Visceral Omentum	0.2540	0.0730	9.0e-04	0.077	NA	0.017	NA	0.037	8.4e-05	NA	4.4e-02	NA	5.1e-03
4	GTEx	Artery Aorta	0.4480	0.0890	8.3e-06	0.230	NA	0.342	NA	0.326	6.6e-13	NA	1.4e-19	NA	1.5e-18
5	GTEx	Artery Tibial	0.4430	0.0540	2.2e-16	0.340	NA	0.319	NA	0.374	1.8e-27	NA	1.4e-25	NA	9.0e-31
6	GTEx	Brain Cerebellum	0.3540	0.1060	2.7e-03	0.012	NA	0.083	NA	0.040	1.4e-01	NA	1.9e-03	NA	2.4e-02
7	GTEx	Breast Mammary Tissue	0.1960	0.0790	5.8e-03	0.110	NA	0.075	NA	0.089	2.8e-06	NA	1.0e-04	NA	2.6e-05
8	GTEx	Colon Sigmoid	0.6750	0.0840	3.7e-05	0.266	NA	0.158	NA	0.208	6.4e-10	NA	3.1e-06	NA	7.1e-08
9	GTEx	Esophagus Muscularis	0.2200	0.0720	5.1e-03	0.047	NA	0.145	NA	0.166	7.3e-04	NA	4.2e-09	NA	2.6e-10
10	GTEx	Heart Atrial Appendage	0.2540	0.0860	6.2e-03	0.171	NA	0.203	NA	0.229	4.0e-08	NA	1.7e-09	NA	1.3e-10
11	GTEx	Nerve Tibial	0.3901	0.0596	6.0e-10	0.176	NA	0.322	NA	0.279	1.7e-12	NA	2.2e-23	NA	6.2e-20
12	GTEx	Pancreas	0.2100	0.0770	2.9e-03	0.164	NA	0.155	NA	0.144	1.9e-07	NA	4.6e-07	NA	1.2e-06
13	GTEx	Testis	0.4120	0.0970	6.3e-04	0.150	NA	0.210	NA	0.243	3.5e-07	NA	1.1e-09	NA	3.9e-11
14	GTEx	Thyroid	0.4780	0.0600	5.0e-14	0.228	NA	0.260	NA	0.304	2.0e-17	NA	6.4e-20	NA	1.2e-23
15	ROSMAP	Brain Pre-frontal Cortex	0.2152	0.0481	2.3e-06	0.059	0.041	0.132	0.102	0.134	4.9e-08	5.0e-06	1.5e-16	5.4e-13	7.5e-17
16	TCGA	Esophageal Carcinoma	0.2390	0.1100	9.7e-03	-0.004	-0.008	-0.009	NA	-0.003	4.6e-01	6.9e-01	7.9e-01	NA	4.1e-01
17	TCGA	Kidney Renal Clear Cell Carcinoma	0.0409	0.0192	3.3e-03	0.014	0.010	0.007	NA	0.011	8.5e-03	2.3e-02	4.6e-02	NA	1.9e-02
18	TCGA	Lung Adenocarcinoma	0.0500	0.0246	9.5e-03	0.006	0.012	0.005	NA	0.014	6.5e-02	1.3e-02	7.9e-02	NA	8.2e-03
19	TCGA	Prostate Adenocarcinoma	0.1892	0.0437	0.0e+00	0.173	0.179	0.188	NA	0.189	9.6e-18	2.1e-18	2.4e-19	NA	2.3e-19

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
HbA1C	6.8	7.5	13.8	0.0	-2.8	-3.0	-3.1	-3.3	2.2	-3.1	-3.4	-3.1	-3.4	-3.7	-2.8	-3.5	-3.4	-0.4	-0.1	-2.9	0.0	-2.3
Smoking status: Current	5.7	9.1	13.4	-1.9	3.5	3.7	3.0	3.3	-3.2	3.4	3.5	3.4	3.3	3.2	3.2	2.8	3.3	-0.8	1.9	3.1	2.0	3.2
Supplements: Calcium	4.8	5.3	9.4	0.5	-2.2	-2.3	-3.0	-3.0	1.2	-2.5	-2.9	-3.1	-2.7	-2.7	-2.5	-2.7	-2.8	-0.3	0.8	-1.6	-1.7	-2.0
Schizophrenia vs Biploar Disorder	4.6	6.0	12.5	0.5	-3.0	-3.5	-2.2	-2.9	2.4	-3.1	-2.7	-1.3	-3.1	-3.2	-3.0	-3.0	-3.1	0.4	0.0	0.0	0.5	-2.8
Breast cancer (self-reported)	4.3	5.2	14.4	1.2	-2.4	-2.8	-2.4	-2.6	0.6	-2.6	-3.8	-3.4	-2.5	-2.4	-2.0	-2.3	-2.4	0.5	-0.1	-1.8	-1.9	-1.8
Ever had bowel cancer screening	4.2	4.9	9.6	-1.0	-1.8	-2.0	-3.1	-2.6	0.5	-2.0	-2.5	-3.0	-2.6	-2.7	-2.4	-2.9	-2.7	-1.9	-2.0	-1.4	-0.8	-1.8
Chronotype (morning person)	3.9	9.0	16.7	0.4	3.3	2.2	3.3	3.8	-4.1	3.6	3.2	2.0	3.9	3.0	3.3	3.5	3.5	1.1	-0.9	4.1	0.5	3.0
Osteoarthritis (self-reported)	3.8	4.9	8.8	0.9	-2.8	-2.5	-2.6	-2.5	1.2	-2.8	-3.0	-0.9	-2.7	-2.3	-2.8	-2.2	-2.6	0.3	-0.7	-2.4	0.2	-2.9
Miserableness	3.7	6.4	12.2	-0.2	2.4	2.3	2.3	3.3	-2.4	3.3	3.5	2.0	3.3	2.5	3.0	3.3	2.9	0.7	-0.4	3.3	0.7	2.2
Mother’s age at death	3.7	4.7	9.6	1.8	-2.2	-2.6	-2.1	-2.4	-0.2	-2.2	-1.9	-3.1	-2.2	-2.6	-2.3	-2.1	-2.2	1.3	-1.5	-2.4	-1.7	-2.6
Exposure to tobacco smoke at home	3.4	3.9	6.9	-0.6	2.1	2.5	1.9	2.4	-1.4	2.4	2.1	2.0	2.2	2.2	2.6	2.1	2.3	-0.6	0.4	2.1	0.6	2.3
Current tobacco smoking	3.3	5.4	9.1	-2.0	2.7	3.0	2.0	2.4	-2.9	2.5	2.8	2.6	2.4	2.2	2.3	1.9	2.4	-0.9	1.9	2.7	1.7	2.4
Number of live births	3.1	4.4	10.3	-1.4	2.0	2.5	2.0	2.2	0.5	1.9	3.0	3.2	2.0	2.0	3.1	1.9	2.0	-0.1	2.1	2.4	0.8	2.0
Bipolar Disorder (2018)	2.8	4.4	10.0	0.5	2.2	2.0	2.5	2.5	1.2	2.5	1.9	2.0	2.7	2.6	3.2	2.9	2.6	1.4	0.0	0.0	-1.3	2.1
Ever used hormone-replacement therapy (HRT)	2.7	3.5	8.6	-1.5	2.3	2.5	1.2	1.8	-0.6	2.3	2.3	2.1	1.7	1.8	2.1	1.5	1.7	-1.5	-0.8	2.9	0.7	2.0
Time employed in main current job	2.6	3.0	6.8	0.4	-1.4	-2.1	-2.1	-2.6	0.6	-2.0	-1.7	-1.8	-2.3	-2.3	-2.1	-2.2	-2.1	-0.5	0.7	-1.3	-1.2	-1.0
Birth weight of first child	2.6	4.8	8.5	-1.1	-2.2	-2.8	-2.4	-2.7	0.1	-2.2	-1.3	-2.4	-2.9	-2.2	-2.4	-2.6	-2.9	-2.3	1.1	-2.0	1.2	-2.5
Ever taken oral contraceptive pill	2.6	2.9	6.2	0.4	2.2	1.9	1.5	1.7	-1.9	2.3	2.1	2.0	1.8	1.4	1.5	1.7	1.7	-0.3	-0.5	1.9	0.4	2.5
Smoking Status	2.3	5.4	11.4	0.1	2.5	2.5	2.6	2.8	-2.3	2.6	3.4	2.6	2.6	2.1	2.5	2.4	2.8	1.0	0.5	2.8	-0.1	2.4
Ever highly irritable/argumentative for 2 days	2.3	2.8	5.8	0.5	-2.3	-2.2	-1.5	-1.6	1.9	-1.8	-2.3	-1.1	-1.6	-1.8	-1.2	-1.4	-1.8	0.7	-0.4	-2.2	-0.5	-2.4
Ever had prostate specific antigen (PSA) test	2.3	2.6	9.2	1.0	-1.6	-2.1	-2.0	-2.1	3.0	-1.6	-1.1	-0.7	-1.8	-1.9	-1.0	-1.5	-1.9	0.2	1.2	-1.4	-1.1	-1.1
Unable to work because of sickness or disability	2.3	3.0	4.7	-1.4	2.2	2.0	2.0	2.0	-0.8	2.0	2.0	2.0	2.0	1.8	1.7	1.6	1.9	-0.5	0.9	2.0	0.9	1.8
Bipolar Disorder (2011)	2.2	2.2	6.1	-0.2	2.0	1.7	1.7	1.9	0.5	1.9	1.8	0.0	2.1	2.5	1.7	1.8	2.1	0.2	0.0	0.0	0.0	0.0
Lupus	2.2	3.3	6.4	-1.0	-1.7	-1.2	-2.2	-2.1	0.4	-2.2	-2.1	-1.1	-2.5	-2.1	-2.5	-2.4	-2.1	-0.7	1.9	-1.4	0.9	-1.8
Financial situation satisfaction	2.2	2.8	5.9	0.8	1.4	2.0	2.1	1.1	-1.4	1.3	0.3	1.6	1.8	2.4	2.0	2.2	1.7	0.3	0.8	1.2	-2.2	2.4
Arm predicted mass (left)	2.2	11.2	21.2	3.4	-4.1	-4.3	-2.7	-3.5	2.5	-3.9	-4.6	-2.4	-3.4	-3.5	-3.0	-3.1	-3.5	2.5	-1.5	-3.5	-2.7	-3.9
Financial difficulties in last 2 years	2.0	2.8	5.7	1.9	1.3	1.5	2.0	1.7	0.5	1.3	0.8	1.6	1.9	1.9	1.7	2.4	2.0	2.2	-0.9	1.2	-1.3	1.9
Whole body fat-free mass	2.0	11.3	20.4	2.7	-4.3	-4.4	-2.9	-3.6	2.3	-4.1	-4.5	-2.4	-3.6	-3.2	-3.4	-3.4	-3.8	1.6	-0.6	-3.7	-2.1	-4.2
Leg fat-free mass (right)	2.0	10.6	18.7	2.6	-4.2	-4.3	-2.8	-3.4	2.4	-4.0	-4.2	-2.4	-3.4	-3.2	-3.3	-3.3	-3.6	1.6	-0.4	-3.6	-1.9	-4.0
Whole body water mass	2.0	11.5	21.2	2.9	-4.4	-4.5	-3.0	-3.6	2.4	-4.2	-4.6	-2.4	-3.6	-3.3	-3.3	-3.4	-3.8	1.7	-0.6	-3.6	-2.3	-4.1
Arm fat-free mass (left)	2.0	10.0	18.5	3.3	-3.9	-4.1	-2.5	-3.3	2.3	-3.6	-4.3	-2.1	-3.1	-3.2	-2.8	-2.9	-3.3	2.5	-1.8	-3.4	-2.7	-3.7
Trunk fat-free mass	1.9	10.7	20.4	2.5	-4.3	-4.2	-2.9	-3.6	2.3	-4.1	-4.5	-2.4	-3.5	-2.9	-3.3	-3.4	-3.7	1.3	-0.2	-3.7	-1.9	-4.1
Trunk predicted mass	1.9	11.0	20.9	2.5	-4.4	-4.3	-2.9	-3.6	2.3	-4.1	-4.6	-2.4	-3.5	-2.9	-3.3	-3.4	-3.8	1.3	-0.2	-3.7	-2.0	-4.2
Arm fat-free mass (right)	1.9	9.8	17.3	3.3	-3.8	-4.2	-2.4	-3.2	2.0	-3.5	-4.1	-2.3	-3.1	-3.2	-2.9	-2.8	-3.3	2.5	-1.6	-3.6	-2.4	-3.7
Pulse wave peak to peak time	1.9	2.2	5.4	0.2	-1.5	-2.3	-1.6	-1.3	0.3	-1.8	-2.3	-1.6	-1.4	-1.6	-1.5	-1.5	-1.4	0.2	-1.2	-2.0	0.8	-1.6
Leg predicted mass (right)	1.9	9.9	17.8	2.5	-4.1	-4.2	-2.8	-3.2	2.2	-3.9	-4.2	-2.3	-3.3	-3.1	-3.2	-3.2	-3.5	1.5	-0.4	-3.5	-1.9	-4.0
Hearing aid user	1.9	2.2	3.6	0.7	1.4	1.5	1.8	1.9	0.7	1.7	1.4	1.6	1.8	0.6	1.7	1.8	1.9	1.9	-1.3	0.7	-0.5	1.7
Alzheimer’s Disease (in mother)	1.8	2.1	3.8	0.8	1.5	1.1	1.6	1.8	-1.1	1.8	1.9	1.0	1.9	1.4	1.8	2.0	1.8	0.8	0.5	0.9	0.7	1.7
Impedance of leg (right)	1.8	8.6	21.0	-0.4	3.5	3.2	2.9	2.9	-4.6	3.2	3.7	2.0	3.2	3.4	2.5	3.5	3.4	0.4	0.7	2.5	-0.5	4.0
Emphysema/chronic bronchitis	1.8	2.0	4.2	1.5	1.2	0.9	1.8	1.2	1.2	1.0	0.7	1.8	1.3	1.1	1.7	1.7	1.6	1.8	0.1	1.4	-2.0	1.7
Suffer from ‘nerves’	1.8	2.8	5.5	-0.4	-2.0	-1.1	-2.4	-2.2	-2.2	-1.6	-1.6	-2.2	-2.1	-1.5	-1.8	-1.7	-2.1	-1.0	-0.4	-0.9	0.5	-2.1
Basal metabolic rate	1.8	9.9	17.5	3.0	-4.0	-4.1	-2.6	-3.2	2.1	-3.8	-4.2	-2.2	-3.2	-3.0	-3.0	-3.0	-3.4	2.2	-0.9	-3.4	-2.4	-3.9
Age at First Birth	1.7	2.5	5.2	-0.9	-1.6	-1.5	-1.8	-2.1	-0.4	-2.0	-1.2	-2.3	-2.2	-1.5	-1.7	-2.2	-2.0	-1.3	0.6	-1.2	-0.3	-0.9
Blood Red Count	1.7	16.0	26.6	1.7	-4.6	-3.6	-5.2	-5.0	2.4	-4.5	-4.7	-4.7	-4.7	-4.5	-5.1	-4.5	-4.6	0.4	-1.7	-3.7	-2.2	-3.7
Hand grip strength (left)	1.7	4.6	9.5	-0.3	-3.0	-2.4	-1.7	-2.2	-1.1	-2.8	-2.0	-1.8	-2.3	-1.2	-3.1	-2.0	-2.5	0.1	1.9	-3.1	0.5	-2.9
Medication for hormone replacement therapy	1.7	1.9	6.7	-1.2	1.5	2.6	1.0	0.8	-0.1	1.6	1.9	1.9	0.8	1.5	1.8	0.9	0.8	-1.4	-0.1	1.5	0.8	1.5
Leg fat-free mass (left)	1.7	8.9	16.7	2.7	-3.7	-4.1	-2.5	-3.0	1.9	-3.6	-4.0	-2.2	-3.0	-3.1	-3.0	-3.0	-3.2	1.7	-1.1	-3.1	-2.1	-3.7
Leg predicted mass (left)	1.7	8.9	16.6	2.7	-3.8	-4.1	-2.5	-3.0	2.0	-3.6	-4.0	-2.2	-3.0	-3.0	-3.0	-3.0	-3.2	1.7	-1.1	-3.1	-2.0	-3.7
Arm predicted mass (right)	1.7	8.9	16.2	3.2	-3.5	-3.9	-2.3	-3.1	1.9	-3.3	-4.0	-2.3	-2.9	-3.0	-2.7	-2.7	-3.1	2.4	-1.6	-3.4	-2.5	-3.4
Comparative height size at age 10	1.7	9.4	16.8	1.0	-3.6	-3.8	-3.0	-3.8	-0.8	-4.1	-3.6	-1.9	-3.8	-2.2	-3.6	-3.8	-3.8	-0.8	2.0	-4.0	-0.9	-3.3
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.4	-1.1	-1.2	-0.7	-1.1	-1.3	0.3	-1.4	-2.1	-1.4	-1.4	-0.9	-1.6	-1.5	-1.4	-1.6	1.0	-1.5	1.3	-1.0
Impedance of leg (left)	1.6	7.6	19.4	-0.4	3.1	3.0	2.8	2.8	-4.4	2.8	3.7	2.0	3.0	3.4	2.2	3.3	3.2	0.8	1.5	1.6	-0.4	3.6
Qualifications: A levels/AS levels or equivalent	1.6	3.5	7.9	-1.2	1.9	1.9	1.8	2.5	-1.9	2.5	2.5	1.0	2.2	1.5	2.2	1.8	1.8	-0.6	-0.5	2.8	2.0	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	5.6	0.8	0.6	1.2	1.4	1.5	-2.4	1.4	2.0	1.1	1.4	1.1	1.5	2.0	1.5	2.2	-0.4	1.1	0.1	0.5
Pain all over the body in last month	1.5	1.7	6.1	-2.0	1.3	0.9	1.1	1.1	-0.0	1.8	2.5	1.1	0.9	1.0	1.1	0.9	0.9	-1.7	-0.0	0.8	1.8	0.7
Had major operations	1.5	1.8	4.1	-0.4	-1.6	-1.4	-1.4	-1.6	0.6	-1.6	-0.5	-1.1	-1.5	-1.5	-2.0	-1.6	-1.6	-0.7	0.2	-1.9	0.0	-1.6
Commuting to job workplace: Public transport	1.5	1.8	4.5	-0.9	-1.1	-1.5	-1.6	-1.6	-0.3	-1.3	-1.9	-0.8	-1.5	-0.8	-2.1	-1.6	-1.5	-1.7	-1.0	-1.3	0.4	-1.1
Number of operations (self-reported)	1.5	2.2	5.0	-1.0	-1.7	-1.1	-1.6	-1.8	0.9	-1.6	-0.5	-2.0	-1.9	-1.6	-2.2	-1.7	-1.8	-1.1	-0.3	-1.3	0.1	-1.5
Allergy or Eczema	1.4	3.6	10.2	-0.3	2.8	1.7	1.6	1.8	-3.2	2.4	1.5	0.8	2.2	1.6	1.7	1.7	2.0	-1.1	-1.4	2.2	-1.6	2.2
Taking other prescription medications	1.4	2.1	8.5	0.5	1.4	0.9	1.4	1.6	-0.1	1.7	1.6	2.9	1.5	0.4	1.6	1.5	1.5	1.3	0.3	1.8	-0.9	1.5
Nervous feelings	1.4	2.6	6.0	-0.4	-1.8	-1.4	-1.8	-1.5	-2.0	-1.7	-1.6	-1.4	-1.8	-1.7	-2.4	-1.8	-1.7	-0.5	-0.3	-1.8	0.8	-2.1
Weight	1.4	7.0	11.4	3.2	-3.1	-3.4	-1.8	-2.5	1.5	-3.1	-3.3	-2.0	-2.5	-2.8	-2.2	-2.1	-2.5	3.0	-1.8	-2.6	-2.7	-3.2
Pulse wave Arterial Stiffness index	1.4	1.6	4.1	-0.1	1.1	2.0	1.4	1.0	-0.4	1.4	2.0	1.4	1.0	1.5	1.1	1.3	1.0	-0.4	1.5	1.6	-0.8	1.3
Medication: Allopurinol	1.4	1.9	6.4	0.8	-1.7	-2.5	-1.3	-1.1	-1.1	-1.1	-1.4	-1.0	-1.4	-1.8	-1.6	-1.2	-1.5	1.1	-1.0	-1.0	0.2	-1.6
Medication: Seretide 50 evohaler	1.4	1.6	3.9	1.2	-1.2	-1.5	-1.2	-1.5	2.0	-0.8	-1.0	-1.1	-1.2	-1.5	-1.2	-0.8	-1.2	0.9	-1.3	-0.0	-2.0	-1.3
Smoking status: Previous	1.4	2.1	5.1	1.0	-1.8	-2.1	-1.3	-1.3	1.6	-1.4	-0.6	-1.3	-1.5	-2.3	-1.0	-1.4	-1.5	1.3	-1.3	-0.8	-1.5	-1.8
Commuting to job workplace: Cycle	1.4	1.6	4.9	-1.6	1.2	1.1	0.8	1.5	-1.0	1.4	1.7	2.2	1.2	1.7	0.4	0.7	1.0	-1.8	0.8	0.8	0.9	0.9
Basal cell carcinoma (self-reported)	1.4	1.7	3.6	0.3	1.5	1.3	1.9	1.3	-1.3	1.3	1.4	1.7	1.2	1.5	1.6	1.5	1.4	0.5	-0.3	0.8	-0.3	1.6
Bipolar Disorder or Schizophrenia	1.3	3.2	6.7	0.3	1.9	1.6	2.0	2.3	2.0	2.1	2.0	1.2	2.3	1.8	2.6	2.2	2.2	1.5	-1.7	0.0	-0.3	1.2
Hearing difficulty/problems: Yes	1.3	1.9	4.9	1.0	1.2	1.0	2.2	1.4	0.2	1.3	1.4	0.4	1.5	1.1	2.1	1.7	1.6	1.8	0.1	1.4	-1.1	1.5
Systolic blood pressure, automated reading	1.3	3.7	11.3	1.5	-1.7	-1.8	-1.5	-1.9	3.4	-1.8	-2.0	-1.7	-1.9	-2.8	-1.4	-1.7	-1.6	1.3	-1.8	-2.0	-2.0	-1.7
Medication: Co-codamol	1.3	1.5	3.9	0.8	0.9	0.5	1.9	1.5	-0.1	0.9	1.0	2.0	1.3	1.1	1.6	1.6	1.4	1.2	0.9	1.0	-0.6	1.0
Maternal smoking around birth	1.3	1.9	3.5	-1.1	1.7	1.9	0.8	1.1	-1.8	1.6	0.9	0.6	1.4	1.7	1.6	1.6	1.4	-0.7	-1.3	1.7	0.4	1.5
Qualifications: CSEs or equivalent	1.3	1.7	4.1	-0.9	1.3	1.5	1.5	1.4	-0.7	1.1	0.7	1.2	1.4	1.8	2.0	1.5	1.5	0.3	1.7	1.1	0.1	1.5
Hip circumference	1.3	5.5	10.7	2.8	-2.9	-2.7	-1.4	-2.0	1.4	-2.7	-2.9	-1.9	-2.0	-2.2	-1.7	-1.8	-2.0	3.3	-1.7	-1.5	-3.1	-2.9
Illnesses of siblings: Diabetes	1.3	1.6	4.4	-0.2	-1.4	-1.7	-1.4	-0.9	0.3	-1.3	-1.1	-0.5	-1.4	-2.1	-1.7	-1.4	-1.3	0.8	-1.1	-1.2	0.8	-1.8
Mood swings	1.3	2.4	7.7	-0.6	1.1	1.9	1.4	2.1	-2.8	1.6	0.9	1.1	1.9	1.7	1.9	1.7	1.8	0.8	0.2	1.9	0.4	0.9
Fractured/broken bones in last 5 years	1.3	1.7	12.6	0.6	-1.1	-1.4	-0.6	-1.0	3.5	-1.2	-2.1	-0.5	-0.9	-1.2	-0.5	-0.9	-1.1	0.1	-1.2	-1.2	-0.5	-0.9
Age started oral contraceptive pill	1.3	1.7	6.5	-1.3	0.2	-0.5	-0.9	-1.0	-1.6	0.0	-1.0	-1.2	-1.1	-1.3	-1.5	-1.4	-1.0	-2.3	-2.5	-1.2	1.1	-0.4
Impedance of whole body	1.3	6.8	23.5	-1.4	2.9	2.6	2.3	2.5	-4.8	2.5	3.6	2.0	2.6	3.1	1.4	2.7	2.7	-0.7	2.0	1.8	0.6	3.4
Stomach or abdominal pain in last month	1.2	1.5	9.6	-0.8	0.9	1.1	1.5	1.1	-1.3	0.7	0.9	3.1	0.8	1.8	1.0	0.7	0.8	-1.0	0.8	0.0	1.5	0.8
Standing height	1.2	11.7	24.5	1.3	-4.1	-4.6	-3.1	-3.9	-1.8	-4.4	-3.7	-2.2	-3.8	-2.0	-4.7	-3.8	-4.1	-0.8	2.8	-4.9	-1.1	-3.3
Exposure to tobacco smoke outside home	1.2	1.6	3.9	1.2	1.2	0.7	1.4	1.4	-0.2	1.3	2.0	1.7	1.4	1.0	1.6	1.4	1.5	1.2	-0.5	0.7	-0.5	1.3
Number of full brothers	1.2	1.5	2.8	1.0	0.9	1.1	1.5	1.7	0.2	1.3	1.4	1.7	1.3	0.8	1.5	1.4	1.4	1.3	0.8	1.4	-0.1	0.8
Worry too long after embarrassment	1.2	2.0	6.7	-0.9	-1.8	-1.0	-1.6	-1.3	-2.6	-1.4	-1.1	0.3	-1.5	-0.3	-1.8	-1.2	-1.5	-0.8	1.1	-1.6	1.3	-1.7
Triglycerides	1.1	1.8	10.1	1.9	0.7	-0.2	0.5	0.9	-2.9	0.7	0.1	0.1	1.1	-0.0	0.6	1.4	1.1	3.2	-1.5	0.6	-1.4	0.4
Cardiovascular Disease	1.1	3.8	7.3	1.2	2.0	2.0	2.7	2.3	0.8	1.7	1.5	2.4	2.2	1.2	2.6	2.1	2.4	2.4	-1.5	1.7	-1.1	1.7
Arm fat mass (right)	1.1	4.4	12.8	3.1	-2.0	-2.1	-1.0	-1.5	1.6	-2.1	-2.5	-1.5	-1.5	-2.4	-1.1	-1.1	-1.4	3.6	-2.7	-1.2	-3.0	-2.2
Chest pain or discomfort	1.1	1.6	4.2	0.1	1.1	0.5	1.9	1.6	-0.9	1.0	0.9	2.1	1.6	1.8	1.6	1.6	1.6	0.8	-1.2	0.5	0.5	0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.4	1.9	0.7	0.7	1.5	1.0	0.2	1.1	0.3	-0.1	1.1	0.5	2.1	1.4	1.0	1.4	0.4	0.9	-1.0	1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.3	5.5	0.8	1.3	0.7	0.7	0.6	0.1	1.4	0.6	1.2	1.2	0.3	1.3	1.4	0.9	0.4	-0.7	2.0	-2.3	1.5
Blood White Count	1.0	7.1	12.9	-0.0	-3.5	-3.0	-2.7	-2.7	-3.5	-3.5	-1.7	-1.6	-3.2	-2.4	-3.6	-3.0	-2.8	0.9	0.6	-2.9	-0.9	-3.5
Hand grip strength (right)	1.0	2.6	5.8	-0.2	-2.0	-2.2	-1.5	-1.7	-1.3	-1.9	-1.8	-1.9	-1.6	-1.2	-2.4	-1.4	-1.8	-0.3	1.1	-1.9	-0.4	-1.9
High blood pressure (mother)	1.0	1.3	3.8	0.8	0.7	0.5	1.7	1.4	0.9	0.6	0.9	1.1	1.3	1.7	1.9	1.5	1.6	0.6	-1.3	0.6	-0.3	0.9
Noisy workplace	1.0	1.3	4.8	-0.7	0.6	0.4	0.8	1.3	-0.6	1.2	2.2	1.8	1.2	1.1	1.1	1.2	1.0	-0.4	1.0	1.3	1.2	0.6
Impedance of arm (left)	1.0	4.6	18.0	-1.8	2.1	2.1	1.5	1.9	-4.2	1.6	3.1	1.6	1.9	2.7	0.5	1.8	1.9	-1.6	2.6	1.7	0.9	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	8.4	-2.9	0.3	1.0	-0.6	0.4	-1.4	0.9	1.5	-0.3	-0.1	-0.0	-0.1	-0.2	-0.2	-1.9	0.6	2.2	2.0	-0.4
Medication: Ibuprofen	1.0	1.2	4.9	-1.6	-0.7	-1.0	-1.2	-0.6	-0.6	-0.3	0.2	-0.5	-1.0	-0.8	-1.3	-1.2	-1.2	-2.2	-0.6	-0.0	1.9	-1.2
Leg fat mass (right)	1.0	3.8	17.8	3.6	-1.3	-1.5	-0.3	-0.8	1.0	-1.3	-1.7	-1.4	-0.7	-1.8	-0.2	-0.2	-0.5	4.2	-3.4	-0.7	-3.4	-1.4
Average weekly red wine intake	1.0	1.4	5.8	-2.0	1.3	1.5	0.1	0.9	0.4	1.3	0.3	1.0	1.0	0.9	0.8	0.4	0.6	-2.2	-1.0	-0.2	2.4	0.6
Arm fat mass (left)	1.0	4.0	13.0	3.1	-1.9	-2.0	-0.9	-1.4	1.4	-1.8	-2.4	-1.4	-1.3	-2.2	-1.0	-0.9	-1.2	3.6	-2.8	-0.9	-2.9	-2.0
Medication: Atorvastatin	1.0	1.2	2.4	0.4	0.8	0.6	1.5	1.4	-1.3	0.9	1.2	1.5	1.2	1.3	1.1	1.3	1.3	0.8	-0.3	1.0	0.9	0.6
Leg fat mass (left)	1.0	4.1	19.3	3.6	-1.4	-1.6	-0.4	-0.9	1.1	-1.4	-1.8	-1.5	-0.8	-2.0	-0.3	-0.3	-0.7	4.4	-3.2	-0.9	-3.4	-1.6
Worry (Nagel 2018)	0.9	1.9	3.4	-1.0	-1.8	-0.7	-1.7	-1.6	-1.6	-1.4	-1.0	-1.1	-1.8	-0.7	-1.5	-1.3	-1.7	-1.0	1.4	-1.2	1.1	-1.4
Mean Putamen Volume	0.9	1.0	2.8	1.1	-0.6	-0.6	-0.9	-1.5	1.0	-0.6	-1.6	-1.7	-1.0	-1.4	-0.3	-0.5	-0.9	0.6	-0.5	0.1	-1.5	-0.2
Ever had hysterectomy (womb removed)	0.9	1.1	5.5	-2.3	-0.2	-0.3	-1.0	-0.6	-0.4	-0.2	-0.0	-0.3	-0.8	-0.9	-1.1	-1.1	-1.0	-1.9	1.0	-0.1	1.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	5.1	-2.2	0.5	1.1	-0.1	0.5	-0.1	0.7	0.7	1.0	0.1	0.1	0.1	-0.5	-0.0	-2.3	0.7	0.1	2.3	-0.1
Medication: Atenolol	0.9	1.1	4.9	1.4	0.6	0.4	1.1	0.2	-0.5	0.6	0.2	1.3	0.4	0.2	1.4	1.0	0.8	1.7	-1.7	0.4	-2.2	0.7
Trunk fat mass	0.9	3.8	16.3	3.6	-1.5	-2.0	-0.6	-1.1	0.2	-1.7	-1.9	-1.4	-1.0	-1.8	-0.8	-0.5	-0.8	4.0	-2.4	-1.1	-3.5	-1.5
Waist circumference	0.9	3.1	8.2	2.3	-2.0	-2.1	-0.9	-1.2	1.0	-1.8	-1.9	-0.7	-1.3	-2.0	-1.4	-1.2	-1.3	2.9	-2.3	-1.4	-2.1	-2.2
Impedance of arm (right)	0.9	4.3	13.1	-1.8	2.1	2.1	1.5	1.9	-3.6	1.7	2.7	1.7	1.8	2.6	0.7	1.8	1.9	-1.6	2.8	1.8	0.8	2.6
Hair/balding pattern: Pattern 3	0.9	1.4	6.7	1.7	0.1	-0.3	1.0	0.6	0.0	0.4	0.5	-0.1	1.0	0.4	0.9	1.2	1.0	2.6	-1.9	0.7	-2.6	-0.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	7.7	0.7	0.4	0.6	1.2	1.0	-0.0	0.3	0.9	2.8	0.9	1.0	0.9	1.0	1.1	1.1	1.6	0.7	-0.1	0.5
Headache pain in last month	0.9	1.6	3.5	1.2	1.4	1.2	1.9	1.4	0.3	1.1	0.4	1.3	1.6	1.0	1.5	1.6	1.5	1.4	0.3	0.9	-0.7	1.6
Leg fat percentage (right)	0.9	3.4	20.4	3.3	0.2	0.1	0.9	0.5	0.6	0.3	-0.3	-0.8	0.7	-0.7	1.3	1.4	0.9	4.5	-3.7	1.0	-3.3	-0.1
Whole body fat mass	0.9	4.0	16.3	3.3	-1.7	-2.0	-0.8	-1.2	0.6	-1.7	-2.0	-1.5	-1.1	-2.0	-0.9	-0.6	-1.0	4.0	-2.6	-0.9	-3.4	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	8.2	-1.8	0.2	-0.3	-1.0	-0.3	0.2	0.0	-0.8	0.1	-0.6	-1.0	-0.2	-1.3	-0.7	-2.9	-1.1	-0.6	1.0	-0.5
Average weekly champagne plus white wine intake	0.9	1.2	3.1	1.8	0.6	-0.2	1.3	1.1	-0.0	0.9	1.6	1.6	1.2	0.5	1.5	1.4	1.0	1.5	-0.5	0.9	-0.3	0.5
Leg fat percentage (left)	0.9	3.3	22.9	3.2	-0.0	-0.1	0.8	0.5	0.8	0.0	-0.3	-1.0	0.5	-0.8	1.2	1.2	0.8	4.8	-3.3	0.6	-3.3	-0.3
Fasting Glucose	0.8	0.9	5.2	-1.7	0.6	1.0	-0.4	0.0	-0.4	0.8	0.6	0.2	-0.0	-0.1	0.5	-0.2	-0.1	-2.3	-0.8	0.9	2.1	0.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	7.2	1.7	-0.4	-0.5	-0.4	0.2	1.2	-0.6	-0.5	-0.6	-0.2	-0.8	-0.7	-0.3	0.2	2.7	0.0	-1.1	-1.1	-0.9
Relative age of first facial hair	0.8	1.7	3.5	-1.1	-1.2	-1.1	-1.8	-1.2	-0.4	-1.2	-1.5	-1.1	-1.5	-1.4	-1.8	-1.9	-1.6	-1.2	1.4	-0.5	0.8	-1.2
Body mass index (BMI)	0.8	3.4	13.0	2.7	-1.4	-1.4	-0.6	-0.9	2.5	-1.2	-1.8	-1.3	-0.9	-2.0	-0.2	-0.5	-0.7	3.6	-3.4	-0.4	-2.5	-1.8
Alcohol usually taken with meals	0.8	1.3	2.4	-0.8	1.1	1.4	1.4	1.6	-1.1	1.5	1.1	1.3	1.4	0.9	1.3	1.3	1.1	-0.0	0.1	0.8	1.4	0.1
Medication: Simvastatin	0.8	1.2	5.5	1.5	-0.7	-1.2	0.1	-0.2	1.0	-0.9	-1.0	-1.6	-0.3	-1.2	-0.5	-0.3	-0.2	2.3	-2.0	-0.8	-1.0	-1.0
Lung cancer (father)	0.8	0.9	4.0	-1.2	0.8	0.6	0.3	0.4	-2.0	0.7	0.3	0.5	0.6	1.2	0.1	0.6	0.5	-1.9	1.4	0.1	0.4	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	4.2	1.5	0.4	0.1	0.8	0.9	0.7	1.0	1.2	0.3	1.1	0.1	0.0	0.9	0.9	2.0	-2.1	0.5	-1.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.6	-0.9	-0.6	-0.6	-1.7	-1.0	0.8	-0.8	-0.9	-1.1	-1.3	-1.9	-1.2	-1.5	-1.2	-0.5	0.0	-0.3	0.1	-0.7
Medication: Omeprazole	0.8	1.0	2.5	0.5	-0.9	-1.1	-0.7	-0.7	0.6	-1.1	-0.3	-1.2	-1.0	-1.5	-0.8	-1.0	-0.9	0.6	-1.3	-1.6	0.2	-1.5
Overall health rating	0.8	1.7	7.1	2.5	0.5	-0.1	1.7	0.6	0.6	0.2	0.4	0.9	0.8	-0.2	2.2	1.3	1.0	2.7	-2.0	-0.1	-1.6	0.3
Family relationship satisfaction	0.8	1.0	2.7	0.5	0.7	1.4	0.7	0.9	0.4	0.9	0.7	0.5	1.1	1.6	1.1	1.2	1.1	0.1	1.1	1.6	-0.8	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	5.8	0.8	-0.5	0.2	0.2	-0.2	1.9	-0.5	-0.3	1.0	-0.0	0.3	0.8	0.1	-0.0	1.1	2.4	-1.0	-1.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.0	1.1	0.8	1.2	1.0	1.2	-0.6	0.8	1.4	0.9	1.1	1.4	1.3	1.4	1.4	1.1	1.1	0.9	-0.3	1.2
Back pain experienced in last month	0.8	1.2	3.9	2.0	-1.0	-1.4	-0.7	-1.2	0.8	-1.3	-0.6	0.1	-1.3	-1.4	-0.8	-1.0	-1.1	1.0	0.2	-1.2	-0.9	-0.9
Mineral and other dietary supplements	0.8	1.0	4.4	1.6	-0.3	0.4	1.0	1.3	-0.5	0.3	1.4	1.9	1.0	0.6	-0.0	0.8	0.8	2.1	-0.6	0.2	0.3	-0.4
Guilty feelings	0.8	1.2	10.0	-1.0	0.3	0.4	0.2	0.8	-3.2	0.7	1.0	1.7	0.7	0.6	0.2	0.5	0.4	-0.2	1.6	0.6	1.3	-0.3
Depressed Affect (Nagel 2018)	0.7	1.5	7.6	0.5	0.6	0.9	1.1	1.5	-2.7	1.2	1.5	0.5	1.3	1.2	1.2	1.7	1.2	1.3	0.2	1.4	0.2	0.5
Rheumatoid Arthritis	0.7	0.9	2.9	-1.2	-1.1	-0.5	-1.2	-1.1	0.6	-0.8	-1.7	-0.8	-1.0	-0.5	-0.8	-1.0	-1.2	-0.6	1.3	-0.0	0.3	-0.9
BMI	0.7	4.0	18.3	3.6	-1.8	-1.5	-0.5	-0.6	2.9	-1.6	-1.8	-0.9	-0.8	-1.5	-0.0	-0.2	-0.5	4.3	-2.5	-0.1	-3.3	-1.8
Height	0.7	13.4	26.0	3.4	-3.6	-4.8	-3.8	-4.3	-3.2	-4.3	-4.0	-3.2	-4.0	-3.1	-4.6	-4.1	-4.2	0.0	0.3	-5.1	-2.1	-2.7
Sitting height	0.7	4.6	9.7	2.0	-2.7	-3.1	-1.6	-2.3	-0.7	-2.6	-3.1	-1.5	-2.0	-1.4	-2.4	-2.3	-2.4	0.7	1.2	-2.5	-1.9	-2.2
Had other major operations	0.7	0.8	1.9	0.3	-1.0	-1.2	-0.6	-0.8	0.7	-0.7	-1.2	-0.6	-0.7	-0.9	-1.2	-0.7	-1.0	-0.1	-1.4	-0.8	-0.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	0.6	1.0	0.7	1.3	1.5	1.0	1.2	0.8	0.9	1.4	0.6	1.6	1.1	1.3	0.7	-1.0	1.2	-0.2	0.7
Body fat percentage	0.7	2.8	18.0	3.2	-0.2	-0.7	0.4	0.1	-0.1	-0.4	-0.5	-0.9	0.2	-1.0	0.4	0.8	0.4	4.2	-3.0	0.3	-3.3	-0.4
Pulse rate, automated reading	0.7	2.1	8.5	1.4	-1.1	-1.4	-1.5	-1.6	2.9	-1.4	-1.1	0.2	-1.6	-2.0	-1.9	-1.4	-1.4	0.6	-1.4	-0.6	-0.8	-1.1
Number of full sisters	0.7	0.8	2.9	0.3	0.8	0.8	0.4	0.9	-0.6	1.3	1.7	1.0	0.9	0.2	0.7	0.8	0.6	0.1	0.3	1.5	1.3	0.9
Leg pain on walking	0.7	0.8	4.6	1.2	0.7	-0.1	0.1	0.4	0.1	0.9	0.1	0.7	0.5	-0.8	0.5	0.5	0.4	1.0	-1.2	2.1	-1.8	0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.0	0.3	-0.6	-0.6	-0.6	-1.4	-0.0	-0.7	-1.3	-0.9	-1.3	-1.7	-0.6	-0.9	-0.9	0.7	-0.7	-0.3	-1.3	-0.7
Irritability	0.7	1.1	3.1	0.9	-1.1	-1.4	-0.4	-0.3	-1.3	-0.8	-1.0	-1.3	-0.6	-1.2	-1.2	-0.5	-0.7	1.8	-1.1	-0.9	-0.1	-1.6
Risk taking	0.7	1.0	4.5	-0.5	0.8	0.7	1.0	1.2	1.2	1.2	0.3	2.1	1.2	1.1	1.2	0.8	0.9	-0.1	0.5	1.2	0.1	0.9
Cholesterol lowering medication	0.7	1.0	10.3	1.0	0.4	-0.3	0.7	0.7	0.5	0.2	-0.4	-0.7	0.4	-0.9	0.1	0.2	0.5	2.1	-3.2	-0.4	0.2	-0.2
Pain experienced in last month	0.7	1.1	5.1	-2.3	-0.8	-0.4	-1.3	-0.8	0.3	-0.6	-0.6	-1.2	-0.8	-0.6	-1.4	-1.2	-0.9	-1.4	-0.4	-0.1	1.6	-0.8
Neuroticism (2016)	0.6	0.9	2.2	-0.1	0.9	1.1	1.0	1.0	-1.5	1.1	0.6	1.2	0.9	1.2	0.6	1.2	0.9	0.8	0.7	0.9	-0.1	0.8
Primary Biliary Cirrhosis	0.6	0.8	3.8	-0.9	0.6	1.1	0.9	1.0	1.9	0.6	0.9	-0.0	0.8	0.6	1.2	0.7	0.7	0.2	0.9	1.2	-0.1	0.5
Hypothyroidism (self reported)	0.6	1.3	3.9	1.6	1.2	1.4	0.8	1.1	-0.6	1.0	0.2	-0.1	1.1	0.3	1.9	1.2	1.3	0.9	-1.0	2.0	-0.8	1.3
Lung FVC	0.6	3.3	11.8	-3.0	1.8	2.6	-0.3	1.0	-1.2	2.1	0.0	-0.6	1.3	1.2	1.3	1.1	1.1	-3.4	0.6	3.4	1.1	1.9
Average weekly spirits intake	0.6	0.8	2.5	-1.3	1.4	0.9	0.1	0.1	-1.3	0.8	-0.0	0.4	0.2	-0.4	0.9	-0.1	0.2	-1.6	1.4	0.4	0.3	1.3
Vitamin and mineral supplements	0.6	0.9	2.4	-0.1	0.1	0.3	1.0	1.3	-0.3	0.8	1.5	0.3	1.0	0.8	0.7	1.1	0.9	0.6	-1.3	1.2	1.5	-0.3
Diabetes (mother)	0.6	0.8	2.5	1.1	-0.4	-1.0	-1.2	-1.2	0.2	-0.7	-1.0	-0.3	-1.0	-1.3	-0.7	-1.0	-0.8	0.1	-0.8	-0.3	-1.6	-0.3
Trunk fat percentage	0.6	2.5	15.8	3.1	-0.4	-1.0	0.2	-0.2	-0.5	-0.6	-0.7	-0.7	-0.1	-1.1	-0.0	0.5	0.1	4.0	-2.5	-0.1	-3.3	-0.5
Age when periods started (menarche)	0.6	1.4	4.1	0.0	1.8	1.8	0.9	1.0	-1.2	1.6	1.8	1.0	1.1	0.8	0.8	0.9	1.1	-0.6	-0.5	0.8	0.9	2.0
Number of incorrect matches in round	0.6	1.0	2.6	0.8	-1.2	-0.5	-1.1	-1.6	1.6	-0.9	-0.9	-0.5	-1.2	-1.0	-1.3	-0.7	-1.2	0.1	0.6	-0.7	-0.9	-0.6
Qualifications: None of the above	0.6	1.2	4.3	0.4	1.2	1.8	0.8	1.1	-0.9	1.2	1.5	0.9	1.0	0.7	0.9	0.9	1.2	0.2	-2.1	1.0	0.4	1.0
Happiness	0.6	0.7	2.0	-0.1	-1.3	-0.4	-1.4	-1.0	-0.3	-0.8	-0.9	-1.3	-1.0	-0.7	-0.8	-0.8	-1.1	-0.6	0.2	-0.6	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	-1.5	0.7	0.6	0.8	1.2	0.0	0.7	0.8	0.3	1.1	1.1	0.5	0.8	0.7	-0.9	0.5	0.3	1.3	0.2
Depression (self-reported)	0.6	0.7	2.2	0.2	-1.4	-1.1	-1.5	-0.9	0.1	-1.0	-0.8	-0.9	-1.1	-0.7	-0.6	-0.7	-0.9	0.6	0.8	0.1	-0.9	-0.9
Breastfed as a baby	0.6	0.8	4.7	-0.5	0.8	1.1	0.3	0.0	-1.3	0.8	-0.0	-0.4	0.5	0.9	0.2	0.3	0.2	-2.2	0.6	1.0	-0.8	1.6
Medication: Amlodipine	0.6	0.8	3.5	-1.1	-0.4	-0.7	-0.6	-0.6	1.9	-0.6	-0.5	1.8	-0.7	-0.8	-0.7	-0.8	-0.6	-0.8	0.2	-0.4	0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.4	-1.2	0.6	0.5	0.9	0.5	1.0	0.6	1.2	1.3	0.2	-0.1	0.5	0.1	0.3	-0.7	1.5	0.9	0.9	0.5
Knee pain experienced in last month	0.6	1.0	2.7	0.9	-1.6	-1.5	-0.4	-0.7	-0.8	-1.6	-1.2	-0.9	-0.9	-0.4	-0.7	-0.6	-0.8	0.5	1.5	-0.8	-0.3	-1.2
Illnesses of father: Heart disease	0.6	0.9	2.6	0.9	0.8	1.2	1.5	0.7	-0.9	0.4	0.6	1.1	0.7	0.3	1.0	0.9	0.9	1.6	0.1	0.1	-1.0	1.1
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.5	-1.1	-1.0	-1.1	-0.7	-0.4	-1.0	-0.4	-0.5	-0.8	-1.1	-0.8	-1.3	-1.0	-0.4	-0.0	-0.5	-0.1	-1.4
Medication for cholesterol	0.6	1.0	5.4	-0.1	-1.1	-1.3	-0.8	-0.5	-1.5	-1.1	-0.5	-0.3	-0.4	0.2	-1.5	-0.5	-0.6	-0.6	2.3	-1.3	-0.1	-0.6
Osteoporosis (self-reported)	0.6	0.7	1.9	0.9	-0.2	0.1	-0.8	-1.1	1.1	-0.9	-0.9	-0.9	-1.0	-1.2	-0.6	-0.8	-0.7	0.6	0.4	-0.9	-1.4	0.0
Medication: Gliclazide	0.6	0.7	2.6	-0.4	-0.8	-0.7	-0.6	-0.5	0.4	-1.0	-0.8	0.1	-0.8	-1.0	-0.8	-1.1	-0.8	-0.7	0.1	-1.6	1.4	-0.9
Medication: Bendroflumethiazide	0.6	0.9	3.8	-0.3	0.9	1.1	0.9	0.4	1.9	1.0	0.9	0.7	0.6	0.2	1.1	0.8	0.7	0.6	-1.6	1.1	-0.2	0.7
Alcohol drinker status: Never	0.6	0.8	6.4	1.1	0.9	0.9	0.3	0.5	2.5	0.6	1.2	0.1	0.4	-0.2	0.8	0.5	0.6	1.1	-0.2	0.1	0.5	0.6
Diastolic blood pressure, automated reading	0.6	1.8	8.2	2.0	0.9	1.1	0.4	0.2	2.7	0.7	0.0	-0.4	0.6	-0.6	1.1	0.7	0.7	1.9	-1.7	0.8	-2.9	1.2
Depression (Nagel 2018)	0.5	0.7	2.3	0.2	0.1	1.0	0.8	0.7	-1.5	0.8	1.3	0.5	0.6	0.5	1.0	1.1	0.7	1.4	0.8	0.5	0.7	0.2
Alzheimer’s Disease (in father)	0.5	0.6	4.6	-0.0	0.6	1.0	0.5	0.6	0.8	0.6	-0.0	2.1	0.6	0.7	0.7	0.6	0.7	-0.3	0.6	0.1	-0.8	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	1.0	0.7	0.7	0.8	0.9	0.5	0.9	0.9	1.1	1.0	0.4	1.1	1.2	1.0	0.8	0.4	-0.0	0.2	1.0
Ulcerative Colitis (UC)	0.5	1.0	7.9	-2.0	0.3	0.2	0.1	-0.3	0.4	0.0	0.2	-0.1	-0.3	0.2	-0.0	-0.3	-0.3	-2.1	2.8	-0.3	1.2	0.3
Breast Cancer	0.5	1.1	5.2	-1.4	0.6	0.3	1.0	1.1	-1.3	0.7	1.8	1.9	0.7	0.5	0.3	0.6	0.7	0.5	0.2	0.1	2.3	0.4
Ovarian Cancer	0.5	0.6	3.9	2.0	-0.2	-0.7	-0.0	-0.8	1.0	-0.2	-0.8	0.0	-0.5	-0.4	-0.1	0.1	-0.3	1.0	-0.3	0.0	-1.8	0.3
Ulcerative Colitis	0.5	0.8	4.2	-2.1	0.4	0.4	0.2	0.3	0.4	0.2	0.9	0.2	0.0	0.1	-0.1	-0.5	0.0	-1.9	1.5	0.0	1.7	0.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	1.1	0.5	-0.5	1.5	1.3	0.1	0.6	0.7	1.0	1.1	0.0	0.9	0.8	1.1	1.8	-1.1	0.0	-0.5	-0.0
Neuroticism	0.5	1.2	9.8	-0.6	-1.4	-1.0	-0.7	-0.6	-3.1	-0.9	-0.5	0.2	-0.7	-0.1	-1.1	-0.4	-0.9	0.5	1.6	-0.7	0.3	-1.5
Number of treatments/medications taken	0.5	0.9	3.5	0.6	1.0	0.4	0.7	0.8	0.6	1.0	0.3	1.3	0.8	-0.3	1.1	0.9	0.9	1.5	-1.9	0.6	-0.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.7	-0.6	-0.7	-0.9	0.1	0.1	-0.2	-0.5	-0.6	0.9	-0.2	-0.0	-0.1	-0.7	-0.3	-0.8	1.1	-0.4	1.6	-1.0
Angina	0.5	0.6	7.5	-0.0	0.2	0.0	0.2	0.3	1.5	-0.3	-0.3	0.5	0.1	-0.3	0.4	-0.1	0.3	0.9	-2.7	-0.5	-0.2	-0.3
Severe depression (siblings)	0.5	0.5	3.6	-0.3	-0.2	0.7	0.2	0.6	0.7	0.6	1.9	-1.2	0.3	-0.2	0.2	0.3	0.2	0.6	0.0	1.2	0.9	-0.4
Pack years adult smoking proportion	0.5	0.7	2.5	-1.0	1.0	0.9	0.4	0.4	-0.3	1.1	-0.1	1.4	0.7	0.4	0.8	0.6	0.5	-1.3	-0.4	1.1	1.6	0.5
Townsend deprivation index at recruitment	0.5	0.7	2.9	-1.2	0.9	0.9	0.2	0.6	-0.7	0.7	0.3	1.7	0.6	1.2	0.4	0.7	0.8	-0.9	-0.1	1.0	0.6	0.8
Fed-up feelings	0.5	1.0	4.9	1.0	0.3	0.6	0.6	0.5	-2.2	0.7	0.9	0.4	0.7	0.4	1.1	1.2	0.6	1.0	0.4	2.0	-1.1	0.7
High blood pressure	0.5	1.4	3.5	0.8	1.1	1.0	1.5	1.0	1.5	0.8	0.9	1.9	0.9	0.2	1.3	0.9	1.2	1.4	-1.4	1.0	-1.5	0.9
Multivitamins +/- minerals	0.5	0.7	6.5	-0.2	-0.1	0.4	-0.5	-0.6	0.1	-0.5	-1.3	0.7	-0.5	0.2	-0.1	-0.4	-0.2	0.4	2.6	-0.3	-1.4	0.1
Heart attack	0.5	0.6	3.6	-0.3	0.2	0.4	0.2	0.3	-1.4	0.0	0.4	1.8	0.4	0.6	-0.0	0.3	0.5	0.2	-1.9	-0.8	0.2	0.2
Allergy	0.5	1.1	8.5	-1.8	-0.8	0.2	-0.0	-0.2	1.3	-0.5	0.5	0.9	-0.6	0.5	0.1	-0.6	-0.6	-1.5	1.3	-0.8	2.9	-0.5
Arm fat percentage (right)	0.5	2.2	10.9	2.5	-0.6	-0.8	-0.0	-0.2	1.4	-0.7	-1.1	-1.0	-0.2	-1.4	0.2	0.2	-0.1	3.3	-2.8	0.3	-2.6	-0.9
Alcohol intake versus 10 years previously	0.5	0.7	1.8	-1.0	-0.6	-0.3	-0.8	-0.8	-0.2	-0.9	-0.5	-0.7	-1.0	-0.8	-1.3	-1.0	-0.8	-0.9	-0.2	-1.4	1.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.2	1.8	-0.2	-0.6	0.1	-0.5	-0.0	-0.2	-0.9	-1.8	-0.1	-0.6	0.4	0.6	-0.1	1.6	-0.3	0.2	-1.8	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	3.1	-1.2	-0.2	-0.4	-0.9	-0.5	-0.3	-0.0	0.2	-0.3	-0.7	-0.3	-1.1	-0.7	-0.8	-1.8	-0.7	0.2	1.2	-0.6
Peak expiratory flow (PEF)	0.5	1.2	8.6	-0.2	-1.1	-0.9	-0.7	-0.6	-2.9	-0.4	-1.7	-1.7	-0.2	-0.6	-1.4	-0.1	-0.7	0.2	-1.0	-0.9	-0.3	-1.1
High blood pressure (siblings)	0.5	0.7	2.2	0.1	0.6	1.1	1.1	0.9	0.6	-0.0	-0.2	1.5	0.7	0.5	1.1	0.6	0.9	0.8	1.4	-0.7	0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	0.3	0.8	-0.3	0.6	1.0	-0.0	1.1	0.2	0.9	1.0	0.5	1.1	1.0	0.9	-0.0	-1.2	1.2	-0.6	0.7
Health satisfaction	0.5	0.6	3.7	1.8	-0.5	-0.8	-0.4	-0.8	0.3	-0.4	-0.3	-0.1	-0.5	-0.9	0.4	-0.2	-0.5	1.0	0.1	-0.4	-1.9	-0.1
Qualifications: College or University degree	0.5	1.6	4.6	-1.1	-0.7	-1.0	-2.2	-1.4	-0.9	-0.6	-1.4	-2.0	-1.1	-1.2	-1.1	-1.3	-1.6	-1.8	0.0	-0.5	1.3	-1.1
Neck or shoulder pain in last month	0.5	0.7	2.2	0.1	1.2	0.4	1.0	0.6	-1.3	1.2	0.7	-0.0	0.8	0.0	1.5	0.8	0.7	-0.3	-1.0	0.3	-0.1	1.0
Angina (self-reported)	0.5	0.6	6.8	0.4	0.1	-0.1	0.1	0.2	1.5	-0.3	-0.3	0.5	0.1	-0.3	0.4	0.0	0.3	1.1	-2.6	-0.5	-0.3	-0.2
Heart disease (mother)	0.5	0.6	2.2	1.5	0.7	0.3	0.8	0.0	-0.3	0.1	-0.5	-0.2	0.3	-0.3	1.1	0.3	0.4	1.0	-1.3	0.2	-1.5	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	7.6	0.4	-0.5	0.0	-0.1	-0.5	0.1	-0.7	-1.1	0.0	-0.6	-0.4	-0.3	-0.3	-0.4	0.4	2.8	-0.5	-0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.7	0.8	-0.5	-0.8	-0.6	-1.0	-0.5	-0.8	-0.4	-0.8	-0.9	-1.3	-0.8	-1.2	-0.9	0.8	0.4	-0.5	-1.2	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.4	1.6	0.1	0.3	0.3	0.2	1.4	0.1	0.8	0.2	0.1	-0.6	0.7	0.5	0.4	1.2	0.3	0.6	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.9	0.5	-1.1	-2.0	-0.8	-0.7	-1.4	-1.3	-1.4	-0.8	-0.5	0.5	-1.1	-0.6	-0.8	-0.5	1.2	-1.6	-0.5	-0.5
Arm fat percentage (left)	0.5	2.1	12.2	2.6	-0.5	-0.6	0.2	-0.1	1.0	-0.5	-0.9	-1.1	-0.0	-1.2	0.2	0.4	0.1	3.5	-3.0	0.4	-2.6	-0.8
Loneliness, isolation	0.5	0.6	6.9	-1.0	0.2	0.4	0.4	0.5	-2.6	0.3	-0.4	0.7	0.5	0.8	0.6	0.4	0.4	-0.2	0.7	0.1	0.4	-0.1
Friendships satisfaction	0.5	0.6	1.9	-0.3	0.8	1.4	-0.0	0.7	-1.2	1.0	0.5	-1.1	0.7	0.5	0.9	0.5	0.7	-0.8	-1.1	0.9	-0.0	0.6
Wears glasses or contact lenses	0.5	0.6	3.4	0.4	0.6	0.6	0.5	0.4	-0.2	0.5	0.1	-0.5	0.5	0.3	0.3	0.8	0.5	1.1	-1.3	1.9	-1.1	0.3
Eye problems/disorders: Glaucoma	0.5	0.6	4.3	0.3	-0.6	-0.6	-0.4	-0.9	0.7	-0.4	-0.8	-1.2	-0.7	-0.2	-0.5	-0.3	-0.7	0.2	2.1	0.4	-1.2	0.1
Medication: Blood pressure	0.5	1.0	4.6	-0.1	0.9	0.6	0.9	0.4	2.2	0.9	0.2	0.8	0.4	-0.4	1.5	0.4	0.7	0.7	-1.7	1.4	-1.4	0.5
High cholesterol (Self-reported)	0.5	0.8	6.2	0.2	0.6	0.0	1.0	1.1	-1.5	0.5	0.3	-0.1	1.0	0.3	0.3	0.8	0.9	1.1	-2.5	0.7	0.2	0.2
Illnesses of father: High blood pressure	0.5	0.6	3.0	-0.9	0.5	1.2	0.7	0.5	1.4	0.1	-0.1	-0.1	0.6	0.8	1.1	0.6	0.8	0.1	-1.7	0.1	-0.2	0.5
Ever depressed for a whole week	0.5	0.6	3.2	0.8	-1.2	-0.9	-0.5	-0.3	-0.4	-0.7	-0.6	-0.3	-0.5	-0.4	-0.6	-0.1	-0.5	1.5	0.5	-0.0	-1.8	-1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.9	-0.5	-1.1	-1.0	-1.6	-1.1	-1.4	-0.8	-0.9	-2.0	-0.9	-0.1	-1.4	-0.9	-1.2	-1.5	1.8	-0.9	1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.6	-0.6	-0.7	-0.7	-0.6	0.4	-0.8	-0.6	-0.4	-0.9	-0.7	-0.4	-0.9	-0.8	-1.0	-0.5	-1.4	1.0	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	3.8	-0.3	0.1	0.3	0.2	0.3	-1.5	0.0	0.3	1.8	0.4	0.6	-0.2	0.3	0.4	0.2	-2.0	-0.8	0.1	0.2
Schizophrenia (2018)	0.4	0.7	4.1	0.1	0.7	0.4	0.5	0.9	1.8	0.7	1.1	-0.1	0.7	0.1	0.8	0.5	0.8	0.8	-2.0	0.0	0.7	-0.2
Reaction Time	0.4	0.7	2.7	0.2	1.0	1.5	0.4	0.7	0.1	0.7	1.0	0.4	0.6	0.5	0.2	0.3	0.8	-0.4	1.6	1.4	-0.4	1.0
Prostate Cancer	0.4	0.6	3.8	-1.9	0.4	0.3	0.3	-0.2	-0.8	0.4	0.6	0.7	-0.3	0.3	0.2	-0.3	-0.1	-2.0	-0.9	0.3	0.8	0.1
LDL Cholesterol	0.4	0.6	3.8	-1.2	0.8	0.3	0.5	0.5	-2.0	0.7	0.2	0.8	0.6	-0.1	0.8	0.2	0.3	0.2	1.3	0.6	0.6	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.4	-0.4	0.2	0.7	-0.1	0.4	-1.6	1.1	0.5	0.0	0.7	0.7	1.0	1.1	0.4	-0.1	0.3	1.1	0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	3.6	-0.5	-0.1	-0.8	-0.9	-0.7	1.9	-0.1	-1.1	0.1	-0.4	-0.9	0.1	-0.5	-0.6	-0.8	-1.1	0.5	0.2	-0.2
Supplements: Zinc	0.4	0.4	1.2	-0.5	0.7	0.3	0.1	0.8	-0.8	0.9	1.1	0.6	0.6	0.3	1.0	0.3	0.5	-0.6	0.7	0.6	0.4	0.5
Medication: Metformin	0.4	0.6	1.7	-0.1	-0.3	-1.2	0.4	0.5	0.0	-0.5	-0.8	1.3	0.2	-0.4	-0.4	-0.3	0.1	1.0	-1.2	-0.8	1.2	-0.9
Average weekly fortified wine intake	0.4	0.5	1.7	-0.2	-0.2	0.2	-0.9	-0.6	1.0	-0.2	-0.4	-0.9	-0.4	-0.8	-1.3	-0.6	-0.4	-0.7	-0.7	-0.9	0.8	-0.7
Relative age voice broke	0.4	0.6	2.0	1.1	-0.8	-1.2	-0.6	-0.5	0.6	-0.8	-0.8	-0.3	-0.6	-1.3	-0.6	-0.9	-0.6	1.4	0.3	-0.5	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.9	0.6	-1.1	-1.0	-0.3	-0.6	-0.8	-1.3	-1.0	-0.7	-0.8	-1.0	-0.9	-0.9	-0.7	1.4	0.1	-1.3	0.8	-1.3
Serious illness, injury or assault to yourself	0.4	0.5	4.5	0.4	-0.4	-0.5	-0.5	-0.3	2.1	-0.5	0.4	-0.5	-0.6	-0.8	-0.4	-0.5	-0.4	0.4	-1.0	-0.5	-0.0	-0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	5.7	0.4	1.2	0.4	0.1	0.3	-2.4	0.9	-0.3	-0.4	0.8	0.1	0.3	0.5	0.6	-0.2	-0.8	1.3	-2.3	0.7
Supplements: Glucosamine	0.4	0.6	4.1	-1.7	0.1	-0.3	-0.4	-0.7	0.5	-0.2	-0.5	-0.9	-0.5	0.2	0.2	-0.4	-0.7	-2.0	0.8	0.1	0.3	-0.0
Chronic bronchitis/emphysema (father)	0.4	0.4	2.3	-1.5	0.1	0.4	-0.4	-0.1	-1.0	-0.0	0.1	0.7	-0.1	-0.6	-0.6	-0.8	-0.3	-1.4	-0.2	-0.3	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	7.9	-0.9	0.3	0.5	0.3	0.2	-2.8	0.7	0.1	-0.0	0.4	0.2	0.6	0.6	0.3	-0.6	-0.5	1.2	0.7	0.3
Mouth/teeth dental problems	0.4	0.6	4.7	-0.8	-0.4	-0.2	-0.7	-0.8	-0.7	-0.4	-0.8	-2.2	-0.4	0.2	-0.5	-0.3	-0.7	-1.0	-0.1	-0.4	-0.0	-0.4
Illnesses of siblings	0.4	0.6	2.2	0.4	0.7	0.4	-0.0	0.1	-0.4	1.0	1.2	-1.2	0.4	0.4	0.2	0.3	0.4	-0.7	-0.7	1.5	-1.1	1.1
Neuroticism score	0.4	0.8	9.4	-0.6	0.1	0.3	0.2	0.6	-3.1	0.6	0.5	0.6	0.6	0.8	0.3	0.8	0.4	-0.2	0.7	0.9	0.5	-0.1
Worrier / anxious feelings	0.4	0.8	3.1	-0.4	-0.7	0.2	-1.0	-0.9	-1.8	-0.8	-0.6	-1.1	-1.0	-0.2	-0.7	-0.8	-0.7	-0.8	1.7	-0.2	-0.6	-0.4
Falls in the last year	0.4	0.5	1.5	1.0	0.7	0.8	1.1	0.5	0.5	0.4	0.8	0.2	0.4	0.9	0.5	0.7	0.8	-0.1	0.4	0.2	-0.8	1.2
Pulse rate	0.4	0.6	1.8	1.2	-0.7	-0.8	-0.6	-0.8	1.1	-0.6	-0.7	0.6	-0.5	-0.8	-0.7	-0.5	-0.6	0.9	-1.0	-0.3	-1.4	-0.5
Tense / ‘highly strung’	0.4	0.7	2.5	-0.5	0.6	0.8	0.8	0.8	-1.6	0.8	0.3	0.8	0.7	1.0	1.2	0.9	0.8	0.1	-0.4	1.5	0.2	0.5
Pulse wave reflection index	0.4	0.5	2.5	-1.4	0.7	1.1	-0.0	0.2	0.0	0.9	0.9	-0.2	0.2	0.4	-0.1	0.1	0.1	-1.6	0.6	1.1	0.6	0.8
Loud music exposure frequency	0.4	0.4	2.1	0.5	-0.5	-0.3	0.5	0.9	0.2	-0.2	-0.1	1.3	0.5	0.6	-0.0	0.2	0.5	1.4	0.5	-0.5	-0.6	-0.5
Glaucoma (self-reported)	0.4	0.5	6.2	-0.9	-0.2	-0.1	0.1	-0.1	0.3	0.1	0.1	-0.4	-0.2	0.8	-0.1	-0.1	-0.2	-1.0	2.5	0.7	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.8	1.2	0.8	0.8	0.3	0.8	-0.7	0.8	0.2	-0.3	0.7	-0.2	1.5	0.8	0.7	0.8	-0.9	1.7	-0.2	0.9
Number of children fathered	0.4	0.4	1.7	-0.7	0.6	1.0	0.7	0.7	-0.4	0.8	1.3	-0.2	0.6	0.2	0.5	0.7	0.5	0.3	0.4	0.2	0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.7	0.5	0.5	-0.3	0.6	0.0	-1.3	0.5	-0.2	-0.2	0.4	0.0	0.6	0.6	0.4	1.1	-0.4	1.0	-1.2	0.7
Medication: Aspirin	0.4	0.5	2.1	0.6	-0.8	-0.9	0.1	-0.5	-0.5	-0.7	-0.1	0.5	-0.6	-0.6	-0.7	-0.3	-0.4	1.1	-1.1	-1.4	-0.2	-1.0
Hypertension (Self-reported)	0.4	1.1	3.2	0.6	1.0	0.9	1.3	0.8	1.6	0.7	0.7	1.8	0.7	0.0	1.2	0.7	1.1	1.2	-1.6	0.7	-1.3	0.7
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.4	0.1	-1.2	-0.8	-0.3	-0.6	0.7	-1.1	-0.6	-0.1	-0.8	-0.7	-0.3	-0.5	-0.6	0.6	-0.0	-0.7	0.0	-1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	0.9	0.3	0.1	0.5	0.3	-1.2	0.5	0.0	-1.1	0.5	1.0	0.5	0.6	0.5	0.1	0.7	1.4	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.2	-1.0	0.5	1.1	-0.6	-0.1	-1.4	0.6	-1.4	-1.8	0.2	0.5	0.0	0.3	0.2	-1.4	-0.5	1.1	0.6	0.8
Myopia	0.4	0.6	2.0	0.7	-0.7	-0.4	-0.8	-0.1	1.4	-0.6	-0.3	-1.3	-0.2	-0.7	-0.7	-0.3	-0.2	1.3	-0.0	-0.5	-0.8	-0.9
Heart disease (siblings)	0.4	0.5	3.9	1.0	-0.6	-0.6	0.2	-0.3	0.5	-0.5	-0.9	-0.4	-0.3	-0.7	0.5	0.1	-0.3	2.0	-0.2	-0.6	-0.5	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	8.9	-0.2	-1.1	-0.1	-0.5	-0.2	-3.0	-0.4	0.3	-0.0	-0.4	0.1	-0.5	0.1	-0.4	0.6	1.0	-0.2	0.8	-0.8
Crohns Disease (2017)	0.3	0.6	1.4	1.0	-0.8	-1.1	-0.3	-0.7	0.3	-1.2	-0.9	-0.5	-0.6	-0.6	-0.6	-0.3	-0.4	0.8	1.1	-0.8	-1.0	-0.6
Major Depression (MDD)	0.3	0.3	1.6	-1.3	0.4	0.7	-0.2	0.5	-0.8	0.5	0.3	1.2	0.4	0.8	-0.3	0.2	0.3	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	0.9	-0.7	-0.8	-0.2	-0.3	1.1	-0.6	-0.4	-0.2	-0.4	-0.4	-0.1	-0.3	-0.3	1.2	0.1	-1.1	-0.6	-0.5
HDL Cholesterol	0.3	0.5	2.2	0.3	0.8	1.1	0.9	0.4	0.4	0.6	0.8	-0.4	0.7	0.9	0.3	0.5	0.8	-0.2	0.0	0.7	-1.5	1.1
Schizophrenia (2014)	0.3	0.6	7.1	0.5	0.0	-0.6	0.0	0.2	2.7	-0.1	0.4	-0.3	-0.0	-0.3	0.2	-0.0	0.1	0.9	-1.2	0.0	0.2	-0.6
Heel T-Score	0.3	2.4	8.8	-2.7	-1.1	-0.9	-1.4	-0.9	0.7	-1.1	-0.6	0.1	-1.4	-0.8	-1.3	-1.8	-1.4	-1.9	0.9	-2.2	3.0	-1.9
Respiratory disease	0.3	0.7	4.8	1.0	-0.4	-0.9	-0.4	-0.6	1.5	-0.1	-0.4	-0.1	-0.6	-0.7	-1.0	-0.2	-0.4	1.0	-0.6	-0.1	-2.2	-0.2
Diabetes (father)	0.3	0.4	2.8	-0.1	-0.1	-0.0	0.1	0.6	-0.8	0.1	0.1	1.2	0.1	-0.1	0.2	-0.1	0.1	0.4	-1.7	-0.2	0.8	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.6	-1.3	0.4	1.1	0.3	0.5	0.1	0.6	1.0	-0.2	0.4	0.7	0.2	0.5	0.4	0.1	-0.3	1.1	0.1	-0.0
Hair/balding pattern: Pattern 2	0.3	0.3	2.1	0.5	-0.6	-1.4	-0.5	-0.5	-0.4	-0.4	-0.5	-0.6	-0.3	-0.5	-0.1	-0.5	-0.6	0.0	0.6	0.3	-0.9	-0.0
Had menopause	0.3	0.4	1.6	0.9	0.7	0.6	0.1	0.1	0.9	0.4	1.3	-0.1	-0.0	0.1	0.2	0.1	0.4	-0.1	-1.0	0.6	-0.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.4	0.4	-0.8	-0.1	-0.3	0.2	-0.3	-0.2	-0.4	0.5	-0.0	0.3	-0.1	0.3	0.0	1.0	0.9	0.9	-1.5	-0.4
Diabetes (self-reported)	0.3	0.4	1.4	0.5	-0.1	-0.8	0.8	0.8	0.2	0.0	-0.6	0.7	0.8	-0.2	0.4	0.3	0.5	1.2	-1.1	-0.5	0.6	-0.7
Medication: Ramipril	0.3	0.4	2.9	0.2	-0.2	0.2	0.2	0.3	1.5	0.1	-0.5	1.1	0.2	-0.6	0.5	-0.1	0.2	0.4	-1.7	-0.1	0.5	-0.6
Father’s age at death	0.3	0.3	1.8	-1.4	0.2	0.5	0.1	0.4	0.4	0.1	-0.2	0.1	0.1	0.5	-0.3	-0.5	0.2	-1.2	-0.2	-0.3	1.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	5.0	-0.8	-0.7	-0.1	-1.0	-0.6	-2.2	-0.2	-1.6	-1.5	-0.1	0.6	-1.1	0.0	-0.5	-1.5	0.5	-0.5	0.2	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	4.0	-0.4	0.2	-0.0	-0.3	-0.4	2.0	0.1	-0.9	0.3	-0.6	-1.1	-0.3	-0.8	-0.3	-0.6	-1.0	0.2	-0.1	0.0
Medication: Cholesterol lowering	0.3	0.5	5.3	0.6	-0.3	-1.2	0.4	0.2	-0.2	-0.4	0.0	0.0	0.4	-0.4	0.1	0.2	0.1	1.3	-2.3	-0.1	-0.8	-0.5
Medication: Lansoprazole	0.3	0.3	1.7	-0.9	0.5	0.2	-0.0	0.1	0.1	0.6	0.4	1.3	-0.1	-0.1	-0.1	0.1	-0.0	-0.7	0.0	0.6	0.5	1.0
Prospective memory result	0.3	0.3	2.6	0.6	-0.1	-0.6	-0.7	0.1	0.1	0.2	0.1	-0.3	0.1	-0.5	-0.8	0.0	-0.2	0.4	-1.6	0.4	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	4.7	-0.9	-0.2	0.4	-1.0	-0.5	-1.6	-0.1	-1.4	-1.3	-0.1	0.9	-0.7	-0.1	-0.3	-2.2	0.9	0.0	0.2	0.4
Blood clot in the leg (DVT)	0.3	0.4	2.1	1.2	-0.2	-0.5	0.1	-0.1	-0.8	-0.6	-0.6	-0.4	0.1	0.4	0.0	0.3	0.2	1.4	0.4	-0.6	-1.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.9	0.1	0.1	0.4	-0.7	-0.6	-0.9	0.2	-0.2	-1.7	-0.4	0.1	-0.2	-0.2	-0.3	-1.0	1.6	0.3	-0.4	0.3
Gout (self-reported)	0.3	0.5	2.3	1.3	-0.7	-1.3	-0.1	-0.2	0.1	-0.3	-0.6	0.2	-0.3	-0.6	-0.5	-0.2	-0.5	1.5	-0.2	-0.5	-0.6	-0.5
Birth weight	0.3	0.6	4.3	-0.2	-0.6	-0.8	0.2	0.0	-2.1	-0.0	1.0	1.4	-0.1	0.0	-0.0	-0.0	-0.4	-0.3	1.6	0.1	0.8	-0.8
Age at first live birth	0.3	0.5	1.6	0.6	-1.1	-1.3	-0.3	-0.7	0.4	-0.7	-0.8	-0.8	-0.7	-0.5	-1.1	-0.5	-0.9	-0.2	0.3	-0.8	-0.2	-1.0
Shortness of breath walking on level ground	0.3	0.4	2.4	0.0	-0.1	-0.5	-0.3	-0.5	-0.2	-0.0	0.3	1.0	-0.4	-0.6	-0.3	-0.4	-0.3	0.2	-1.6	0.4	-1.3	0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	4.0	1.0	0.1	-0.2	0.1	-0.4	2.0	-0.2	-0.5	-1.3	-0.1	-0.4	0.3	-0.1	-0.1	0.8	0.8	0.1	-1.4	0.5
Medication: Blood pressure	0.3	0.6	5.7	-0.6	-0.3	-0.2	0.5	0.2	0.8	-0.4	0.1	2.4	-0.1	-0.3	-0.2	-0.2	-0.1	0.3	-0.6	-1.1	1.2	-0.8
Migraine (self-reported)	0.3	0.4	1.5	-0.2	0.2	0.5	1.2	0.9	0.6	0.1	0.1	0.9	0.5	0.5	0.3	0.5	0.6	0.9	0.3	-0.4	1.2	0.0
Alcohol intake frequency.	0.3	0.7	3.3	0.9	-0.9	-1.1	-0.1	-0.6	1.5	-0.9	-0.8	-0.3	-0.7	-0.9	-0.3	-0.2	-0.6	1.8	0.5	-1.0	-0.3	-0.6
Diabetes diagnosed by doctor	0.3	0.4	1.9	0.0	-0.0	-0.8	0.9	0.7	0.6	0.0	-0.7	1.1	0.7	-0.1	0.5	0.2	0.5	0.8	-1.4	-0.6	0.3	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.5	0.6	0.9	0.0	0.6	0.6	0.8	0.6	0.6	-0.9	0.6	0.2	1.2	0.5	0.6	0.5	-0.2	1.1	-1.2	0.5
Medication: Aspirin	0.3	0.4	1.6	0.0	-0.8	-0.9	0.1	-0.4	-0.5	-0.6	0.1	0.6	-0.5	-0.4	-0.7	-0.3	-0.4	0.7	-0.4	-1.3	0.0	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	-0.8	0.9	0.4	-0.1	-0.3	-0.1	0.3	-0.5	-0.8	0.1	0.2	0.8	0.3	0.2	-1.0	0.3	1.0	-0.7	1.2
Medication: Lisinopril	0.3	0.4	2.7	0.6	0.4	0.5	0.7	0.3	0.4	-0.3	-0.2	0.7	0.3	0.1	0.5	0.3	0.5	1.5	-0.2	0.0	-1.6	0.4
Average weekly beer plus cider intake	0.3	0.4	1.5	-1.2	0.1	0.2	0.1	-0.2	-0.7	0.3	1.2	-1.1	-0.0	1.1	-0.0	0.5	0.1	-1.2	0.5	0.1	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.9	1.1	-0.3	-0.4	0.0	-0.3	-0.4	-0.7	-0.7	-0.7	-0.1	0.2	-0.2	0.1	0.1	1.4	0.5	-0.5	-1.2	-0.1
Irritable Bowel Disease (IBD)	0.2	0.6	6.5	-1.0	-0.0	-0.2	0.0	-0.4	0.7	-0.5	-0.5	0.1	-0.4	-0.0	-0.2	-0.3	-0.3	-1.2	2.5	-0.5	0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-0.4	0.4	0.8	0.0	0.9	-0.9	0.9	1.0	0.2	0.5	0.8	0.3	0.3	0.5	-0.6	0.2	1.3	1.1	0.0
Crohns Disease (2012)	0.2	0.4	1.4	1.0	-0.4	0.2	0.6	0.4	0.4	-0.2	0.6	0.5	0.4	0.7	0.1	0.7	0.5	1.1	1.2	0.0	-0.8	-0.2
Blood Eosinophil Count	0.2	1.4	9.3	1.4	0.1	-0.2	0.7	0.8	-3.0	0.5	0.9	0.6	0.7	0.7	0.3	0.8	0.6	1.9	-2.1	0.7	-1.6	0.0
Lung FEV1/FVC ratio	0.2	0.9	6.0	-0.4	0.6	0.7	-0.4	0.4	-1.8	0.7	-0.9	-1.8	0.8	-0.1	0.0	0.9	0.5	0.7	-2.4	0.5	0.3	-0.4
Sensitivity / hurt feelings	0.2	0.4	2.3	-1.5	-0.4	0.5	-0.5	0.1	-0.8	0.0	0.4	0.9	0.0	0.6	0.2	0.1	-0.1	-0.4	1.4	-0.1	0.8	-0.5
Medication: Levothyroxine sodium	0.2	0.4	2.3	0.8	0.5	0.4	-0.1	0.1	0.2	0.3	0.4	-0.7	0.2	-0.7	1.0	0.3	0.2	0.4	-1.5	0.8	-0.0	0.6
Hearing difficulty/problems with background noise	0.2	0.3	2.1	0.4	-0.0	0.0	0.7	0.2	1.4	0.2	0.7	0.5	0.2	-0.3	1.1	0.3	0.1	0.9	-0.1	0.6	0.2	-0.2
Forced vital capacity (FVC)	0.2	0.8	3.7	-0.7	-0.8	-0.0	-0.8	-0.6	-1.9	-0.3	-1.3	-0.9	-0.2	0.8	-0.9	-0.1	-0.5	-1.9	1.0	-0.3	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	4.0	0.8	-0.1	-0.2	0.9	0.5	-1.6	-0.2	-0.5	-0.0	0.4	0.1	0.4	0.4	0.4	2.0	-0.2	0.4	-0.0	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.7	-0.2	-0.0	0.1	-0.6	-0.2	-1.3	-0.3	-1.2	0.2	-0.0	-0.2	-0.4	-0.3	-0.3	0.2	-0.2	0.8	-0.8	-0.1
Asthma	0.2	0.5	1.7	0.5	-0.3	-1.0	-0.4	0.0	1.2	0.1	-0.2	-0.3	-0.1	-1.0	-0.7	-0.1	-0.1	1.0	-1.3	0.1	-0.7	-0.8
Illnesses of mother	0.2	0.2	1.0	-0.7	-0.4	-0.1	-0.2	-0.4	-0.4	-0.3	0.4	-0.1	-0.4	-0.2	-0.9	-0.4	-0.4	-0.6	1.0	-0.2	0.3	-0.3
Length of working week for main job	0.2	0.2	0.8	0.6	0.3	0.2	0.3	0.0	-0.3	0.4	-0.4	-0.9	0.3	0.3	-0.1	0.7	0.1	0.0	-0.1	0.9	0.1	0.6
Hair/balding pattern: Pattern 4	0.2	0.5	2.2	0.0	-0.5	-0.5	-0.6	-0.4	0.0	-1.0	-0.4	0.6	-0.9	-1.0	-0.9	-1.0	-0.5	-0.3	-0.2	-1.5	1.0	-0.6
Medication: Paracetamol	0.2	0.4	1.3	-1.0	0.8	1.0	-0.1	0.5	-0.5	0.7	0.4	0.4	0.5	0.4	0.2	0.4	0.5	-0.5	-0.6	1.1	0.5	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.2	-0.2	0.5	1.1	-0.5	0.1	0.8	0.2	-0.6	0.1	0.2	-0.3	0.2	0.2	0.3	-0.4	-0.6	0.6	0.1	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	5.9	-0.8	-0.0	0.5	-0.6	-0.2	-1.1	-0.0	-1.1	-0.5	0.0	1.2	-0.3	-0.1	-0.2	-2.4	1.7	0.1	0.2	0.7
Comparative body size at age 10	0.2	0.4	2.4	0.3	0.2	-0.1	1.2	0.6	1.6	0.0	-0.1	-0.1	0.3	0.2	0.7	0.4	0.5	1.3	-0.1	-0.6	0.7	-0.2
Mean time to correctly identify matches	0.2	0.5	1.9	0.9	0.9	1.2	0.2	0.3	0.6	0.4	0.9	0.3	0.3	-0.0	0.0	0.1	0.5	0.1	0.5	1.2	-1.4	0.9
Age at last live birth	0.2	0.3	3.1	0.1	-0.5	-0.2	0.3	-0.2	0.8	0.2	0.3	0.1	-0.1	-0.0	-0.3	0.3	-0.4	-0.0	1.8	0.6	-0.3	-0.3
Supplements: Vitamin C	0.2	0.3	2.4	-0.6	0.4	-0.6	-0.1	-0.2	-0.4	0.5	-0.1	0.3	0.2	-0.1	-0.1	0.0	-0.3	-1.6	0.5	-0.6	0.4	0.5
Long-standing illness, disability or infirmity	0.2	0.2	1.8	0.5	0.4	-0.1	0.2	0.1	-0.4	0.2	-0.0	1.4	0.0	-0.9	0.4	0.0	0.1	0.8	-0.3	0.5	-0.2	0.1
Eye problems/disorders: Cataract	0.2	0.2	1.0	-0.2	0.2	0.5	-0.2	-0.2	0.4	0.2	-0.1	0.6	-0.2	-0.3	-0.1	-0.2	-0.1	-1.0	1.0	-0.2	0.3	0.5
Asthma (self-reported)	0.2	0.4	1.6	0.4	-0.4	-0.9	-0.2	0.2	1.0	0.1	-0.1	0.1	-0.0	-0.8	-0.7	-0.0	-0.0	1.3	-1.3	0.1	-0.6	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	3.0	0.7	-0.4	-0.4	0.2	0.2	0.8	-0.5	-0.1	0.3	-0.2	-0.6	0.4	0.1	0.1	1.7	-0.4	-0.1	-0.2	-0.7
Ever smoked	0.2	0.3	1.8	-1.2	-0.0	0.3	0.4	0.5	-0.4	0.4	1.4	0.6	0.4	0.4	0.3	0.1	0.2	-0.6	-0.0	0.8	0.2	0.2
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.8	-0.6	-0.2	-0.6	-0.5	0.7	-0.2	-0.7	0.1	-0.5	-0.4	-0.1	-0.4	-0.6	-0.3	0.4	-0.0	0.4	-0.5
Pack years of smoking	0.2	0.4	1.9	-0.7	0.5	0.5	-0.0	-0.2	0.3	0.7	-0.5	1.0	0.1	-0.1	0.3	0.1	0.0	-1.2	-0.7	0.5	1.4	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	2.5	-0.2	-0.3	0.1	-0.5	0.2	-1.6	0.3	0.5	-0.3	0.1	0.7	-0.5	-0.1	-0.1	-1.4	0.3	1.1	0.0	-0.4
Coronary Artery Disease (CAD)	0.1	0.2	1.7	0.1	0.4	0.1	-0.5	-0.1	-1.3	0.2	-0.2	-0.2	0.1	-0.7	-0.3	-0.1	-0.0	0.3	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.1	0.6	3.6	-0.3	0.7	0.3	0.6	0.7	-1.9	0.6	0.9	1.3	0.7	0.1	-0.6	0.6	0.6	-0.1	-0.8	-0.0	0.7	0.6
Systolic Blood Pressure	0.1	0.5	5.2	0.4	-0.3	0.0	0.2	-0.2	2.3	-0.3	-0.8	0.3	-0.1	-0.8	0.1	-0.0	0.1	1.3	0.2	-0.7	-0.9	-0.2
Tanning	0.1	0.8	7.7	0.9	0.5	-0.4	0.6	1.0	2.8	0.7	0.4	0.4	0.7	-0.4	1.3	0.4	0.6	0.6	-0.7	0.7	0.2	0.5
Past tobacco smoking	0.1	0.3	1.3	-0.1	0.4	0.5	-0.1	-0.3	-0.3	-0.1	-1.2	-0.1	-0.1	0.6	-0.3	0.1	-0.0	-0.9	0.9	-0.6	0.6	0.5
Fluid intelligence score	0.1	0.2	1.3	0.2	-0.4	-0.2	-0.7	-0.2	-0.4	-0.2	-0.3	-1.1	-0.3	-0.3	-0.4	-0.2	-0.3	-0.0	0.8	0.7	0.3	-0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.2	-0.6	-0.5	-0.3	-0.2	0.1	-0.3	0.2	-0.0	-0.3	-0.7	-0.5	-0.2	-0.4	0.9	-0.4	0.0	-0.1	-0.6
Eye problems/disorders: None of the above	0.1	0.1	0.9	-0.2	0.1	0.2	0.0	0.2	-0.3	-0.0	0.4	-0.2	0.3	0.1	0.2	0.2	0.1	0.2	-1.0	-0.2	0.4	-0.3
Medication: Paracetamol	0.1	0.2	1.1	-0.6	0.2	0.6	-0.2	0.1	-0.8	0.4	0.2	0.0	0.3	0.4	-0.0	0.4	0.2	-0.6	-0.6	1.1	0.2	0.3
Blood Platelet Count	0.0	0.5	2.0	0.3	-0.9	-0.5	0.1	-0.3	1.2	-0.8	0.1	-0.4	-0.5	-0.9	-0.8	-0.1	-0.2	1.2	0.2	-1.4	0.1	-1.1
Hair Pigment	0.0	0.5	3.5	1.1	-0.0	-0.0	-0.1	-0.1	0.5	-0.1	-0.4	0.6	-0.3	-0.4	-0.9	-0.3	-0.1	1.1	1.1	-0.1	-1.9	0.3

Hub : Genes

CDC25B

Models

Trait associations