Hub : Genes

CDC25B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2270 0.0460 1.6e-08 0.124 0.117 0.181 0.177 0.171 7.3e-15 4.4e-14 1.5e-21 4.5e-21 2.7e-20
2 GTEx Adipose Subcutaneous 0.1640 0.0500 3.8e-04 0.132 NA 0.108 NA 0.110 6.3e-11 NA 4.1e-09 NA 2.8e-09
3 GTEx Adipose Visceral Omentum 0.2540 0.0730 9.0e-04 0.077 NA 0.017 NA 0.037 8.4e-05 NA 4.4e-02 NA 5.1e-03
4 GTEx Artery Aorta 0.4480 0.0890 8.3e-06 0.230 NA 0.342 NA 0.326 6.6e-13 NA 1.4e-19 NA 1.5e-18
5 GTEx Artery Tibial 0.4430 0.0540 2.2e-16 0.340 NA 0.319 NA 0.374 1.8e-27 NA 1.4e-25 NA 9.0e-31
6 GTEx Brain Cerebellum 0.3540 0.1060 2.7e-03 0.012 NA 0.083 NA 0.040 1.4e-01 NA 1.9e-03 NA 2.4e-02
7 GTEx Breast Mammary Tissue 0.1960 0.0790 5.8e-03 0.110 NA 0.075 NA 0.089 2.8e-06 NA 1.0e-04 NA 2.6e-05
8 GTEx Colon Sigmoid 0.6750 0.0840 3.7e-05 0.266 NA 0.158 NA 0.208 6.4e-10 NA 3.1e-06 NA 7.1e-08
9 GTEx Esophagus Muscularis 0.2200 0.0720 5.1e-03 0.047 NA 0.145 NA 0.166 7.3e-04 NA 4.2e-09 NA 2.6e-10
10 GTEx Heart Atrial Appendage 0.2540 0.0860 6.2e-03 0.171 NA 0.203 NA 0.229 4.0e-08 NA 1.7e-09 NA 1.3e-10
11 GTEx Nerve Tibial 0.3901 0.0596 6.0e-10 0.176 NA 0.322 NA 0.279 1.7e-12 NA 2.2e-23 NA 6.2e-20
12 GTEx Pancreas 0.2100 0.0770 2.9e-03 0.164 NA 0.155 NA 0.144 1.9e-07 NA 4.6e-07 NA 1.2e-06
13 GTEx Testis 0.4120 0.0970 6.3e-04 0.150 NA 0.210 NA 0.243 3.5e-07 NA 1.1e-09 NA 3.9e-11
14 GTEx Thyroid 0.4780 0.0600 5.0e-14 0.228 NA 0.260 NA 0.304 2.0e-17 NA 6.4e-20 NA 1.2e-23
15 ROSMAP Brain Pre-frontal Cortex 0.2152 0.0481 2.3e-06 0.059 0.041 0.132 0.102 0.134 4.9e-08 5.0e-06 1.5e-16 5.4e-13 7.5e-17
16 TCGA Esophageal Carcinoma 0.2390 0.1100 9.7e-03 -0.004 -0.008 -0.009 NA -0.003 4.6e-01 6.9e-01 7.9e-01 NA 4.1e-01
17 TCGA Kidney Renal Clear Cell Carcinoma 0.0409 0.0192 3.3e-03 0.014 0.010 0.007 NA 0.011 8.5e-03 2.3e-02 4.6e-02 NA 1.9e-02
18 TCGA Lung Adenocarcinoma 0.0500 0.0246 9.5e-03 0.006 0.012 0.005 NA 0.014 6.5e-02 1.3e-02 7.9e-02 NA 8.2e-03
19 TCGA Prostate Adenocarcinoma 0.1892 0.0437 0.0e+00 0.173 0.179 0.188 NA 0.189 9.6e-18 2.1e-18 2.4e-19 NA 2.3e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 2.8 4.4 10.0 0.5 2.2 2.0 2.5 2.5 1.2 2.5 1.9 2.0 2.7 2.6 3.2 2.9 2.6 1.4 0.0 0.0 -1.3 2.1
Bipolar Disorder or Schizophrenia 1.3 3.2 6.7 0.3 1.9 1.6 2.0 2.3 2.0 2.1 2.0 1.2 2.3 1.8 2.6 2.2 2.2 1.5 -1.7 0.0 -0.3 1.2
Depressed Affect (Nagel 2018) 0.7 1.5 7.6 0.5 0.6 0.9 1.1 1.5 -2.7 1.2 1.5 0.5 1.3 1.2 1.2 1.7 1.2 1.3 0.2 1.4 0.2 0.5
Depression (Nagel 2018) 0.5 0.7 2.3 0.2 0.1 1.0 0.8 0.7 -1.5 0.8 1.3 0.5 0.6 0.5 1.0 1.1 0.7 1.4 0.8 0.5 0.7 0.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 2.5 -0.2 -0.3 0.1 -0.5 0.2 -1.6 0.3 0.5 -0.3 0.1 0.7 -0.5 -0.1 -0.1 -1.4 0.3 1.1 0.0 -0.4
Neuroticism (Nagel 2018) 0.3 0.7 8.9 -0.2 -1.1 -0.1 -0.5 -0.2 -3.0 -0.4 0.3 -0.0 -0.4 0.1 -0.5 0.1 -0.4 0.6 1.0 -0.2 0.8 -0.8
Schizophrenia (2018) 0.4 0.7 4.1 0.1 0.7 0.4 0.5 0.9 1.8 0.7 1.1 -0.1 0.7 0.1 0.8 0.5 0.8 0.8 -2.0 0.0 0.7 -0.2
Schizophrenia vs Biploar Disorder 4.6 6.0 12.5 0.5 -3.0 -3.5 -2.2 -2.9 2.4 -3.1 -2.7 -1.3 -3.1 -3.2 -3.0 -3.0 -3.1 0.4 0.0 0.0 0.5 -2.8
Worry (Nagel 2018) 0.9 1.9 3.4 -1.0 -1.8 -0.7 -1.7 -1.6 -1.6 -1.4 -1.0 -1.1 -1.8 -0.7 -1.5 -1.3 -1.7 -1.0 1.4 -1.2 1.1 -1.4
Alzheimer’s Disease (in mother) 1.8 2.1 3.8 0.8 1.5 1.1 1.6 1.8 -1.1 1.8 1.9 1.0 1.9 1.4 1.8 2.0 1.8 0.8 0.5 0.9 0.7 1.7
Alzheimer’s Disease (in father) 0.5 0.6 4.6 -0.0 0.6 1.0 0.5 0.6 0.8 0.6 -0.0 2.1 0.6 0.7 0.7 0.6 0.7 -0.3 0.6 0.1 -0.8 0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 1.0 0.7 0.7 0.8 0.9 0.5 0.9 0.9 1.1 1.0 0.4 1.1 1.2 1.0 0.8 0.4 -0.0 0.2 1.0
Crohns Disease (2017) 0.3 0.6 1.4 1.0 -0.8 -1.1 -0.3 -0.7 0.3 -1.2 -0.9 -0.5 -0.6 -0.6 -0.6 -0.3 -0.4 0.8 1.1 -0.8 -1.0 -0.6
Irritable Bowel Disease (IBD) 0.2 0.6 6.5 -1.0 -0.0 -0.2 0.0 -0.4 0.7 -0.5 -0.5 0.1 -0.4 -0.0 -0.2 -0.3 -0.3 -1.2 2.5 -0.5 0.5 0.0
Ulcerative Colitis (UC) 0.5 1.0 7.9 -2.0 0.3 0.2 0.1 -0.3 0.4 0.0 0.2 -0.1 -0.3 0.2 -0.0 -0.3 -0.3 -2.1 2.8 -0.3 1.2 0.3
Major Depression (MDD) 0.3 0.3 1.6 -1.3 0.4 0.7 -0.2 0.5 -0.8 0.5 0.3 1.2 0.4 0.8 -0.3 0.2 0.3 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.4 0.7 2.7 0.2 1.0 1.5 0.4 0.7 0.1 0.7 1.0 0.4 0.6 0.5 0.2 0.3 0.8 -0.4 1.6 1.4 -0.4 1.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.6 -0.4 0.4 0.8 0.0 0.9 -0.9 0.9 1.0 0.2 0.5 0.8 0.3 0.3 0.5 -0.6 0.2 1.3 1.1 0.0
Breast Cancer 0.5 1.1 5.2 -1.4 0.6 0.3 1.0 1.1 -1.3 0.7 1.8 1.9 0.7 0.5 0.3 0.6 0.7 0.5 0.2 0.1 2.3 0.4
Ovarian Cancer 0.5 0.6 3.9 2.0 -0.2 -0.7 -0.0 -0.8 1.0 -0.2 -0.8 0.0 -0.5 -0.4 -0.1 0.1 -0.3 1.0 -0.3 0.0 -1.8 0.3
Prostate Cancer 0.4 0.6 3.8 -1.9 0.4 0.3 0.3 -0.2 -0.8 0.4 0.6 0.7 -0.3 0.3 0.2 -0.3 -0.1 -2.0 -0.9 0.3 0.8 0.1
Age at First Birth 1.7 2.5 5.2 -0.9 -1.6 -1.5 -1.8 -2.1 -0.4 -2.0 -1.2 -2.3 -2.2 -1.5 -1.7 -2.2 -2.0 -1.3 0.6 -1.2 -0.3 -0.9
Bipolar Disorder (2011) 2.2 2.2 6.1 -0.2 2.0 1.7 1.7 1.9 0.5 1.9 1.8 0.0 2.1 2.5 1.7 1.8 2.1 0.2 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.4 0.9 -0.7 -0.8 -0.2 -0.3 1.1 -0.6 -0.4 -0.2 -0.4 -0.4 -0.1 -0.3 -0.3 1.2 0.1 -1.1 -0.6 -0.5
Coronary Artery Disease (CAD) 0.1 0.2 1.7 0.1 0.4 0.1 -0.5 -0.1 -1.3 0.2 -0.2 -0.2 0.1 -0.7 -0.3 -0.1 -0.0 0.3 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.2 0.4 1.4 1.0 -0.4 0.2 0.6 0.4 0.4 -0.2 0.6 0.5 0.4 0.7 0.1 0.7 0.5 1.1 1.2 0.0 -0.8 -0.2
Mean Putamen Volume 0.9 1.0 2.8 1.1 -0.6 -0.6 -0.9 -1.5 1.0 -0.6 -1.6 -1.7 -1.0 -1.4 -0.3 -0.5 -0.9 0.6 -0.5 0.1 -1.5 -0.2
Fasting Glucose 0.8 0.9 5.2 -1.7 0.6 1.0 -0.4 0.0 -0.4 0.8 0.6 0.2 -0.0 -0.1 0.5 -0.2 -0.1 -2.3 -0.8 0.9 2.1 0.3
HbA1C 6.8 7.5 13.8 0.0 -2.8 -3.0 -3.1 -3.3 2.2 -3.1 -3.4 -3.1 -3.4 -3.7 -2.8 -3.5 -3.4 -0.4 -0.1 -2.9 0.0 -2.3
HDL Cholesterol 0.3 0.5 2.2 0.3 0.8 1.1 0.9 0.4 0.4 0.6 0.8 -0.4 0.7 0.9 0.3 0.5 0.8 -0.2 0.0 0.7 -1.5 1.1
LDL Cholesterol 0.4 0.6 3.8 -1.2 0.8 0.3 0.5 0.5 -2.0 0.7 0.2 0.8 0.6 -0.1 0.8 0.2 0.3 0.2 1.3 0.6 0.6 0.1
Lupus 2.2 3.3 6.4 -1.0 -1.7 -1.2 -2.2 -2.1 0.4 -2.2 -2.1 -1.1 -2.5 -2.1 -2.5 -2.4 -2.1 -0.7 1.9 -1.4 0.9 -1.8
Neuroticism (2016) 0.6 0.9 2.2 -0.1 0.9 1.1 1.0 1.0 -1.5 1.1 0.6 1.2 0.9 1.2 0.6 1.2 0.9 0.8 0.7 0.9 -0.1 0.8
Primary Biliary Cirrhosis 0.6 0.8 3.8 -0.9 0.6 1.1 0.9 1.0 1.9 0.6 0.9 -0.0 0.8 0.6 1.2 0.7 0.7 0.2 0.9 1.2 -0.1 0.5
Rheumatoid Arthritis 0.7 0.9 2.9 -1.2 -1.1 -0.5 -1.2 -1.1 0.6 -0.8 -1.7 -0.8 -1.0 -0.5 -0.8 -1.0 -1.2 -0.6 1.3 -0.0 0.3 -0.9
Schizophrenia (2014) 0.3 0.6 7.1 0.5 0.0 -0.6 0.0 0.2 2.7 -0.1 0.4 -0.3 -0.0 -0.3 0.2 -0.0 0.1 0.9 -1.2 0.0 0.2 -0.6
Triglycerides 1.1 1.8 10.1 1.9 0.7 -0.2 0.5 0.9 -2.9 0.7 0.1 0.1 1.1 -0.0 0.6 1.4 1.1 3.2 -1.5 0.6 -1.4 0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 7.2 1.7 -0.4 -0.5 -0.4 0.2 1.2 -0.6 -0.5 -0.6 -0.2 -0.8 -0.7 -0.3 0.2 2.7 0.0 -1.1 -1.1 -0.9
Ulcerative Colitis 0.5 0.8 4.2 -2.1 0.4 0.4 0.2 0.3 0.4 0.2 0.9 0.2 0.0 0.1 -0.1 -0.5 0.0 -1.9 1.5 0.0 1.7 0.0
Blood Eosinophil Count 0.2 1.4 9.3 1.4 0.1 -0.2 0.7 0.8 -3.0 0.5 0.9 0.6 0.7 0.7 0.3 0.8 0.6 1.9 -2.1 0.7 -1.6 0.0
Blood Platelet Count 0.0 0.5 2.0 0.3 -0.9 -0.5 0.1 -0.3 1.2 -0.8 0.1 -0.4 -0.5 -0.9 -0.8 -0.1 -0.2 1.2 0.2 -1.4 0.1 -1.1
Blood Red Count 1.7 16.0 26.6 1.7 -4.6 -3.6 -5.2 -5.0 2.4 -4.5 -4.7 -4.7 -4.7 -4.5 -5.1 -4.5 -4.6 0.4 -1.7 -3.7 -2.2 -3.7
Blood White Count 1.0 7.1 12.9 -0.0 -3.5 -3.0 -2.7 -2.7 -3.5 -3.5 -1.7 -1.6 -3.2 -2.4 -3.6 -3.0 -2.8 0.9 0.6 -2.9 -0.9 -3.5
Heel T-Score 0.3 2.4 8.8 -2.7 -1.1 -0.9 -1.4 -0.9 0.7 -1.1 -0.6 0.1 -1.4 -0.8 -1.3 -1.8 -1.4 -1.9 0.9 -2.2 3.0 -1.9
BMI 0.7 4.0 18.3 3.6 -1.8 -1.5 -0.5 -0.6 2.9 -1.6 -1.8 -0.9 -0.8 -1.5 -0.0 -0.2 -0.5 4.3 -2.5 -0.1 -3.3 -1.8
Height 0.7 13.4 26.0 3.4 -3.6 -4.8 -3.8 -4.3 -3.2 -4.3 -4.0 -3.2 -4.0 -3.1 -4.6 -4.1 -4.2 0.0 0.3 -5.1 -2.1 -2.7
Waist Hip Ratio (WHR) 0.1 0.6 3.6 -0.3 0.7 0.3 0.6 0.7 -1.9 0.6 0.9 1.3 0.7 0.1 -0.6 0.6 0.6 -0.1 -0.8 -0.0 0.7 0.6
Systolic Blood Pressure 0.1 0.5 5.2 0.4 -0.3 0.0 0.2 -0.2 2.3 -0.3 -0.8 0.3 -0.1 -0.8 0.1 -0.0 0.1 1.3 0.2 -0.7 -0.9 -0.2
Smoking Status 2.3 5.4 11.4 0.1 2.5 2.5 2.6 2.8 -2.3 2.6 3.4 2.6 2.6 2.1 2.5 2.4 2.8 1.0 0.5 2.8 -0.1 2.4
Allergy or Eczema 1.4 3.6 10.2 -0.3 2.8 1.7 1.6 1.8 -3.2 2.4 1.5 0.8 2.2 1.6 1.7 1.7 2.0 -1.1 -1.4 2.2 -1.6 2.2
Cardiovascular Disease 1.1 3.8 7.3 1.2 2.0 2.0 2.7 2.3 0.8 1.7 1.5 2.4 2.2 1.2 2.6 2.1 2.4 2.4 -1.5 1.7 -1.1 1.7
Hypothyroidism (self reported) 0.6 1.3 3.9 1.6 1.2 1.4 0.8 1.1 -0.6 1.0 0.2 -0.1 1.1 0.3 1.9 1.2 1.3 0.9 -1.0 2.0 -0.8 1.3
Respiratory disease 0.3 0.7 4.8 1.0 -0.4 -0.9 -0.4 -0.6 1.5 -0.1 -0.4 -0.1 -0.6 -0.7 -1.0 -0.2 -0.4 1.0 -0.6 -0.1 -2.2 -0.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 3.1 1.1 0.5 -0.5 1.5 1.3 0.1 0.6 0.7 1.0 1.1 0.0 0.9 0.8 1.1 1.8 -1.1 0.0 -0.5 -0.0
Lung FEV1/FVC ratio 0.2 0.9 6.0 -0.4 0.6 0.7 -0.4 0.4 -1.8 0.7 -0.9 -1.8 0.8 -0.1 0.0 0.9 0.5 0.7 -2.4 0.5 0.3 -0.4
Lung FVC 0.6 3.3 11.8 -3.0 1.8 2.6 -0.3 1.0 -1.2 2.1 0.0 -0.6 1.3 1.2 1.3 1.1 1.1 -3.4 0.6 3.4 1.1 1.9
Neuroticism 0.5 1.2 9.8 -0.6 -1.4 -1.0 -0.7 -0.6 -3.1 -0.9 -0.5 0.2 -0.7 -0.1 -1.1 -0.4 -0.9 0.5 1.6 -0.7 0.3 -1.5
Chronotype (morning person) 3.9 9.0 16.7 0.4 3.3 2.2 3.3 3.8 -4.1 3.6 3.2 2.0 3.9 3.0 3.3 3.5 3.5 1.1 -0.9 4.1 0.5 3.0
Hair Pigment 0.0 0.5 3.5 1.1 -0.0 -0.0 -0.1 -0.1 0.5 -0.1 -0.4 0.6 -0.3 -0.4 -0.9 -0.3 -0.1 1.1 1.1 -0.1 -1.9 0.3
Tanning 0.1 0.8 7.7 0.9 0.5 -0.4 0.6 1.0 2.8 0.7 0.4 0.4 0.7 -0.4 1.3 0.4 0.6 0.6 -0.7 0.7 0.2 0.5
Hand grip strength (left) 1.7 4.6 9.5 -0.3 -3.0 -2.4 -1.7 -2.2 -1.1 -2.8 -2.0 -1.8 -2.3 -1.2 -3.1 -2.0 -2.5 0.1 1.9 -3.1 0.5 -2.9
Number of treatments/medications taken 0.5 0.9 3.5 0.6 1.0 0.4 0.7 0.8 0.6 1.0 0.3 1.3 0.8 -0.3 1.1 0.9 0.9 1.5 -1.9 0.6 -0.8 0.7
Average weekly spirits intake 0.6 0.8 2.5 -1.3 1.4 0.9 0.1 0.1 -1.3 0.8 -0.0 0.4 0.2 -0.4 0.9 -0.1 0.2 -1.6 1.4 0.4 0.3 1.3
Sensitivity / hurt feelings 0.2 0.4 2.3 -1.5 -0.4 0.5 -0.5 0.1 -0.8 0.0 0.4 0.9 0.0 0.6 0.2 0.1 -0.1 -0.4 1.4 -0.1 0.8 -0.5
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.4 -0.4 0.2 0.7 -0.1 0.4 -1.6 1.1 0.5 0.0 0.7 0.7 1.0 1.1 0.4 -0.1 0.3 1.1 0.8 0.2
Hearing difficulty/problems: Yes 1.3 1.9 4.9 1.0 1.2 1.0 2.2 1.4 0.2 1.3 1.4 0.4 1.5 1.1 2.1 1.7 1.6 1.8 0.1 1.4 -1.1 1.5
Relative age of first facial hair 0.8 1.7 3.5 -1.1 -1.2 -1.1 -1.8 -1.2 -0.4 -1.2 -1.5 -1.1 -1.5 -1.4 -1.8 -1.9 -1.6 -1.2 1.4 -0.5 0.8 -1.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 3.6 -0.5 -0.1 -0.8 -0.9 -0.7 1.9 -0.1 -1.1 0.1 -0.4 -0.9 0.1 -0.5 -0.6 -0.8 -1.1 0.5 0.2 -0.2
Ever used hormone-replacement therapy (HRT) 2.7 3.5 8.6 -1.5 2.3 2.5 1.2 1.8 -0.6 2.3 2.3 2.1 1.7 1.8 2.1 1.5 1.7 -1.5 -0.8 2.9 0.7 2.0
Ever had hysterectomy (womb removed) 0.9 1.1 5.5 -2.3 -0.2 -0.3 -1.0 -0.6 -0.4 -0.2 -0.0 -0.3 -0.8 -0.9 -1.1 -1.1 -1.0 -1.9 1.0 -0.1 1.8 -0.4
Systolic blood pressure, automated reading 1.3 3.7 11.3 1.5 -1.7 -1.8 -1.5 -1.9 3.4 -1.8 -2.0 -1.7 -1.9 -2.8 -1.4 -1.7 -1.6 1.3 -1.8 -2.0 -2.0 -1.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.7 -0.6 -0.7 -0.9 0.1 0.1 -0.2 -0.5 -0.6 0.9 -0.2 -0.0 -0.1 -0.7 -0.3 -0.8 1.1 -0.4 1.6 -1.0
Angina 0.5 0.6 7.5 -0.0 0.2 0.0 0.2 0.3 1.5 -0.3 -0.3 0.5 0.1 -0.3 0.4 -0.1 0.3 0.9 -2.7 -0.5 -0.2 -0.3
Medication for hormone replacement therapy 1.7 1.9 6.7 -1.2 1.5 2.6 1.0 0.8 -0.1 1.6 1.9 1.9 0.8 1.5 1.8 0.9 0.8 -1.4 -0.1 1.5 0.8 1.5
Vitamin and mineral supplements 0.6 0.9 2.4 -0.1 0.1 0.3 1.0 1.3 -0.3 0.8 1.5 0.3 1.0 0.8 0.7 1.1 0.9 0.6 -1.3 1.2 1.5 -0.3
Supplements: Zinc 0.4 0.4 1.2 -0.5 0.7 0.3 0.1 0.8 -0.8 0.9 1.1 0.6 0.6 0.3 1.0 0.3 0.5 -0.6 0.7 0.6 0.4 0.5
Medication: Co-codamol 1.3 1.5 3.9 0.8 0.9 0.5 1.9 1.5 -0.1 0.9 1.0 2.0 1.3 1.1 1.6 1.6 1.4 1.2 0.9 1.0 -0.6 1.0
Medication: Metformin 0.4 0.6 1.7 -0.1 -0.3 -1.2 0.4 0.5 0.0 -0.5 -0.8 1.3 0.2 -0.4 -0.4 -0.3 0.1 1.0 -1.2 -0.8 1.2 -0.9
Diabetes (father) 0.3 0.4 2.8 -0.1 -0.1 -0.0 0.1 0.6 -0.8 0.1 0.1 1.2 0.1 -0.1 0.2 -0.1 0.1 0.4 -1.7 -0.2 0.8 -0.9
Diabetes (mother) 0.6 0.8 2.5 1.1 -0.4 -1.0 -1.2 -1.2 0.2 -0.7 -1.0 -0.3 -1.0 -1.3 -0.7 -1.0 -0.8 0.1 -0.8 -0.3 -1.6 -0.3
Severe depression (siblings) 0.5 0.5 3.6 -0.3 -0.2 0.7 0.2 0.6 0.7 0.6 1.9 -1.2 0.3 -0.2 0.2 0.3 0.2 0.6 0.0 1.2 0.9 -0.4
Pack years adult smoking proportion 0.5 0.7 2.5 -1.0 1.0 0.9 0.4 0.4 -0.3 1.1 -0.1 1.4 0.7 0.4 0.8 0.6 0.5 -1.3 -0.4 1.1 1.6 0.5
Impedance of leg (right) 1.8 8.6 21.0 -0.4 3.5 3.2 2.9 2.9 -4.6 3.2 3.7 2.0 3.2 3.4 2.5 3.5 3.4 0.4 0.7 2.5 -0.5 4.0
Leg fat-free mass (left) 1.7 8.9 16.7 2.7 -3.7 -4.1 -2.5 -3.0 1.9 -3.6 -4.0 -2.2 -3.0 -3.1 -3.0 -3.0 -3.2 1.7 -1.1 -3.1 -2.1 -3.7
Trunk fat percentage 0.6 2.5 15.8 3.1 -0.4 -1.0 0.2 -0.2 -0.5 -0.6 -0.7 -0.7 -0.1 -1.1 -0.0 0.5 0.1 4.0 -2.5 -0.1 -3.3 -0.5
Hand grip strength (right) 1.0 2.6 5.8 -0.2 -2.0 -2.2 -1.5 -1.7 -1.3 -1.9 -1.8 -1.9 -1.6 -1.2 -2.4 -1.4 -1.8 -0.3 1.1 -1.9 -0.4 -1.9
Townsend deprivation index at recruitment 0.5 0.7 2.9 -1.2 0.9 0.9 0.2 0.6 -0.7 0.7 0.3 1.7 0.6 1.2 0.4 0.7 0.8 -0.9 -0.1 1.0 0.6 0.8
Current tobacco smoking 3.3 5.4 9.1 -2.0 2.7 3.0 2.0 2.4 -2.9 2.5 2.8 2.6 2.4 2.2 2.3 1.9 2.4 -0.9 1.9 2.7 1.7 2.4
Average weekly fortified wine intake 0.4 0.5 1.7 -0.2 -0.2 0.2 -0.9 -0.6 1.0 -0.2 -0.4 -0.9 -0.4 -0.8 -1.3 -0.6 -0.4 -0.7 -0.7 -0.9 0.8 -0.7
Maternal smoking around birth 1.3 1.9 3.5 -1.1 1.7 1.9 0.8 1.1 -1.8 1.6 0.9 0.6 1.4 1.7 1.6 1.6 1.4 -0.7 -1.3 1.7 0.4 1.5
Fed-up feelings 0.5 1.0 4.9 1.0 0.3 0.6 0.6 0.5 -2.2 0.7 0.9 0.4 0.7 0.4 1.1 1.2 0.6 1.0 0.4 2.0 -1.1 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 1.9 5.6 0.8 0.6 1.2 1.4 1.5 -2.4 1.4 2.0 1.1 1.4 1.1 1.5 2.0 1.5 2.2 -0.4 1.1 0.1 0.5
Relative age voice broke 0.4 0.6 2.0 1.1 -0.8 -1.2 -0.6 -0.5 0.6 -0.8 -0.8 -0.3 -0.6 -1.3 -0.6 -0.9 -0.6 1.4 0.3 -0.5 -0.4 -0.8
Taking other prescription medications 1.4 2.1 8.5 0.5 1.4 0.9 1.4 1.6 -0.1 1.7 1.6 2.9 1.5 0.4 1.6 1.5 1.5 1.3 0.3 1.8 -0.9 1.5
Age when periods started (menarche) 0.6 1.4 4.1 0.0 1.8 1.8 0.9 1.0 -1.2 1.6 1.8 1.0 1.1 0.8 0.8 0.9 1.1 -0.6 -0.5 0.8 0.9 2.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.6 -1.3 0.4 1.1 0.3 0.5 0.1 0.6 1.0 -0.2 0.4 0.7 0.2 0.5 0.4 0.1 -0.3 1.1 0.1 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.9 0.6 -1.1 -1.0 -0.3 -0.6 -0.8 -1.3 -1.0 -0.7 -0.8 -1.0 -0.9 -0.9 -0.7 1.4 0.1 -1.3 0.8 -1.3
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 4.4 -1.1 -1.2 -0.7 -1.1 -1.3 0.3 -1.4 -2.1 -1.4 -1.4 -0.9 -1.6 -1.5 -1.4 -1.6 1.0 -1.5 1.3 -1.0
Qualifications: CSEs or equivalent 1.3 1.7 4.1 -0.9 1.3 1.5 1.5 1.4 -0.7 1.1 0.7 1.2 1.4 1.8 2.0 1.5 1.5 0.3 1.7 1.1 0.1 1.5
Serious illness, injury or assault to yourself 0.4 0.5 4.5 0.4 -0.4 -0.5 -0.5 -0.3 2.1 -0.5 0.4 -0.5 -0.6 -0.8 -0.4 -0.5 -0.4 0.4 -1.0 -0.5 -0.0 -0.7
High blood pressure 0.5 1.4 3.5 0.8 1.1 1.0 1.5 1.0 1.5 0.8 0.9 1.9 0.9 0.2 1.3 0.9 1.2 1.4 -1.4 1.0 -1.5 0.9
Hayfever, allergic rhinitis or eczema 0.4 0.9 5.7 0.4 1.2 0.4 0.1 0.3 -2.4 0.9 -0.3 -0.4 0.8 0.1 0.3 0.5 0.6 -0.2 -0.8 1.3 -2.3 0.7
Multivitamins +/- minerals 0.5 0.7 6.5 -0.2 -0.1 0.4 -0.5 -0.6 0.1 -0.5 -1.3 0.7 -0.5 0.2 -0.1 -0.4 -0.2 0.4 2.6 -0.3 -1.4 0.1
Stomach or abdominal pain in last month 1.2 1.5 9.6 -0.8 0.9 1.1 1.5 1.1 -1.3 0.7 0.9 3.1 0.8 1.8 1.0 0.7 0.8 -1.0 0.8 0.0 1.5 0.8
Supplements: Glucosamine 0.4 0.6 4.1 -1.7 0.1 -0.3 -0.4 -0.7 0.5 -0.2 -0.5 -0.9 -0.5 0.2 0.2 -0.4 -0.7 -2.0 0.8 0.1 0.3 -0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 5.1 -2.2 0.5 1.1 -0.1 0.5 -0.1 0.7 0.7 1.0 0.1 0.1 0.1 -0.5 -0.0 -2.3 0.7 0.1 2.3 -0.1
Medication: Atenolol 0.9 1.1 4.9 1.4 0.6 0.4 1.1 0.2 -0.5 0.6 0.2 1.3 0.4 0.2 1.4 1.0 0.8 1.7 -1.7 0.4 -2.2 0.7
Medication: Levothyroxine sodium 0.2 0.4 2.3 0.8 0.5 0.4 -0.1 0.1 0.2 0.3 0.4 -0.7 0.2 -0.7 1.0 0.3 0.2 0.4 -1.5 0.8 -0.0 0.6
Sitting height 0.7 4.6 9.7 2.0 -2.7 -3.1 -1.6 -2.3 -0.7 -2.6 -3.1 -1.5 -2.0 -1.4 -2.4 -2.3 -2.4 0.7 1.2 -2.5 -1.9 -2.2
Chronic bronchitis/emphysema (father) 0.4 0.4 2.3 -1.5 0.1 0.4 -0.4 -0.1 -1.0 -0.0 0.1 0.7 -0.1 -0.6 -0.6 -0.8 -0.3 -1.4 -0.2 -0.3 0.6 0.1
High blood pressure (mother) 1.0 1.3 3.8 0.8 0.7 0.5 1.7 1.4 0.9 0.6 0.9 1.1 1.3 1.7 1.9 1.5 1.6 0.6 -1.3 0.6 -0.3 0.9
Body mass index (BMI) 0.8 3.4 13.0 2.7 -1.4 -1.4 -0.6 -0.9 2.5 -1.2 -1.8 -1.3 -0.9 -2.0 -0.2 -0.5 -0.7 3.6 -3.4 -0.4 -2.5 -1.8
Impedance of leg (left) 1.6 7.6 19.4 -0.4 3.1 3.0 2.8 2.8 -4.4 2.8 3.7 2.0 3.0 3.4 2.2 3.3 3.2 0.8 1.5 1.6 -0.4 3.6
Leg predicted mass (left) 1.7 8.9 16.6 2.7 -3.8 -4.1 -2.5 -3.0 2.0 -3.6 -4.0 -2.2 -3.0 -3.0 -3.0 -3.0 -3.2 1.7 -1.1 -3.1 -2.0 -3.7
Trunk fat mass 0.9 3.8 16.3 3.6 -1.5 -2.0 -0.6 -1.1 0.2 -1.7 -1.9 -1.4 -1.0 -1.8 -0.8 -0.5 -0.8 4.0 -2.4 -1.1 -3.5 -1.5
Waist circumference 0.9 3.1 8.2 2.3 -2.0 -2.1 -0.9 -1.2 1.0 -1.8 -1.9 -0.7 -1.3 -2.0 -1.4 -1.2 -1.3 2.9 -2.3 -1.4 -2.1 -2.2
Number of incorrect matches in round 0.6 1.0 2.6 0.8 -1.2 -0.5 -1.1 -1.6 1.6 -0.9 -0.9 -0.5 -1.2 -1.0 -1.3 -0.7 -1.2 0.1 0.6 -0.7 -0.9 -0.6
Past tobacco smoking 0.1 0.3 1.3 -0.1 0.4 0.5 -0.1 -0.3 -0.3 -0.1 -1.2 -0.1 -0.1 0.6 -0.3 0.1 -0.0 -0.9 0.9 -0.6 0.6 0.5
Alcohol usually taken with meals 0.8 1.3 2.4 -0.8 1.1 1.4 1.4 1.6 -1.1 1.5 1.1 1.3 1.4 0.9 1.3 1.3 1.1 -0.0 0.1 0.8 1.4 0.1
Nervous feelings 1.4 2.6 6.0 -0.4 -1.8 -1.4 -1.8 -1.5 -2.0 -1.7 -1.6 -1.4 -1.8 -1.7 -2.4 -1.8 -1.7 -0.5 -0.3 -1.8 0.8 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 7.9 -0.9 0.3 0.5 0.3 0.2 -2.8 0.7 0.1 -0.0 0.4 0.2 0.6 0.6 0.3 -0.6 -0.5 1.2 0.7 0.3
Hearing difficulty/problems with background noise 0.2 0.3 2.1 0.4 -0.0 0.0 0.7 0.2 1.4 0.2 0.7 0.5 0.2 -0.3 1.1 0.3 0.1 0.9 -0.1 0.6 0.2 -0.2
Hair/balding pattern: Pattern 2 0.3 0.3 2.1 0.5 -0.6 -1.4 -0.5 -0.5 -0.4 -0.4 -0.5 -0.6 -0.3 -0.5 -0.1 -0.5 -0.6 0.0 0.6 0.3 -0.9 -0.0
Had menopause 0.3 0.4 1.6 0.9 0.7 0.6 0.1 0.1 0.9 0.4 1.3 -0.1 -0.0 0.1 0.2 0.1 0.4 -0.1 -1.0 0.6 -0.6 0.8
Had other major operations 0.7 0.8 1.9 0.3 -1.0 -1.2 -0.6 -0.8 0.7 -0.7 -1.2 -0.6 -0.7 -0.9 -1.2 -0.7 -1.0 -0.1 -1.4 -0.8 -0.9 -1.2
Forced vital capacity (FVC) 0.2 0.8 3.7 -0.7 -0.8 -0.0 -0.8 -0.6 -1.9 -0.3 -1.3 -0.9 -0.2 0.8 -0.9 -0.1 -0.5 -1.9 1.0 -0.3 0.2 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 4.0 0.8 -0.1 -0.2 0.9 0.5 -1.6 -0.2 -0.5 -0.0 0.4 0.1 0.4 0.4 0.4 2.0 -0.2 0.4 -0.0 -0.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 2.4 0.4 -0.8 -0.1 -0.3 0.2 -0.3 -0.2 -0.4 0.5 -0.0 0.3 -0.1 0.3 0.0 1.0 0.9 0.9 -1.5 -0.4
Qualifications: None of the above 0.6 1.2 4.3 0.4 1.2 1.8 0.8 1.1 -0.9 1.2 1.5 0.9 1.0 0.7 0.9 0.9 1.2 0.2 -2.1 1.0 0.4 1.0
Financial difficulties in last 2 years 2.0 2.8 5.7 1.9 1.3 1.5 2.0 1.7 0.5 1.3 0.8 1.6 1.9 1.9 1.7 2.4 2.0 2.2 -0.9 1.2 -1.3 1.9
Mouth/teeth dental problems 0.4 0.6 4.7 -0.8 -0.4 -0.2 -0.7 -0.8 -0.7 -0.4 -0.8 -2.2 -0.4 0.2 -0.5 -0.3 -0.7 -1.0 -0.1 -0.4 -0.0 -0.4
Heart attack 0.5 0.6 3.6 -0.3 0.2 0.4 0.2 0.3 -1.4 0.0 0.4 1.8 0.4 0.6 -0.0 0.3 0.5 0.2 -1.9 -0.8 0.2 0.2
Allergy 0.5 1.1 8.5 -1.8 -0.8 0.2 -0.0 -0.2 1.3 -0.5 0.5 0.9 -0.6 0.5 0.1 -0.6 -0.6 -1.5 1.3 -0.8 2.9 -0.5
Pain all over the body in last month 1.5 1.7 6.1 -2.0 1.3 0.9 1.1 1.1 -0.0 1.8 2.5 1.1 0.9 1.0 1.1 0.9 0.9 -1.7 -0.0 0.8 1.8 0.7
Diabetes (self-reported) 0.3 0.4 1.4 0.5 -0.1 -0.8 0.8 0.8 0.2 0.0 -0.6 0.7 0.8 -0.2 0.4 0.3 0.5 1.2 -1.1 -0.5 0.6 -0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.7 -0.2 -0.0 0.1 -0.6 -0.2 -1.3 -0.3 -1.2 0.2 -0.0 -0.2 -0.4 -0.3 -0.3 0.2 -0.2 0.8 -0.8 -0.1
Medication: Ramipril 0.3 0.4 2.9 0.2 -0.2 0.2 0.2 0.3 1.5 0.1 -0.5 1.1 0.2 -0.6 0.5 -0.1 0.2 0.4 -1.7 -0.1 0.5 -0.6
Medication: Simvastatin 0.8 1.2 5.5 1.5 -0.7 -1.2 0.1 -0.2 1.0 -0.9 -1.0 -1.6 -0.3 -1.2 -0.5 -0.3 -0.2 2.3 -2.0 -0.8 -1.0 -1.0
Fluid intelligence score 0.1 0.2 1.3 0.2 -0.4 -0.2 -0.7 -0.2 -0.4 -0.2 -0.3 -1.1 -0.3 -0.3 -0.4 -0.2 -0.3 -0.0 0.8 0.7 0.3 -0.6
Illnesses of siblings 0.4 0.6 2.2 0.4 0.7 0.4 -0.0 0.1 -0.4 1.0 1.2 -1.2 0.4 0.4 0.2 0.3 0.4 -0.7 -0.7 1.5 -1.1 1.1
Neuroticism score 0.4 0.8 9.4 -0.6 0.1 0.3 0.2 0.6 -3.1 0.6 0.5 0.6 0.6 0.8 0.3 0.8 0.4 -0.2 0.7 0.9 0.5 -0.1
Weight 1.4 7.0 11.4 3.2 -3.1 -3.4 -1.8 -2.5 1.5 -3.1 -3.3 -2.0 -2.5 -2.8 -2.2 -2.1 -2.5 3.0 -1.8 -2.6 -2.7 -3.2
Impedance of arm (right) 0.9 4.3 13.1 -1.8 2.1 2.1 1.5 1.9 -3.6 1.7 2.7 1.7 1.8 2.6 0.7 1.8 1.9 -1.6 2.8 1.8 0.8 2.6
Arm fat percentage (right) 0.5 2.2 10.9 2.5 -0.6 -0.8 -0.0 -0.2 1.4 -0.7 -1.1 -1.0 -0.2 -1.4 0.2 0.2 -0.1 3.3 -2.8 0.3 -2.6 -0.9
Trunk fat-free mass 1.9 10.7 20.4 2.5 -4.3 -4.2 -2.9 -3.6 2.3 -4.1 -4.5 -2.4 -3.5 -2.9 -3.3 -3.4 -3.7 1.3 -0.2 -3.7 -1.9 -4.1
Hip circumference 1.3 5.5 10.7 2.8 -2.9 -2.7 -1.4 -2.0 1.4 -2.7 -2.9 -1.9 -2.0 -2.2 -1.7 -1.8 -2.0 3.3 -1.7 -1.5 -3.1 -2.9
Time employed in main current job 2.6 3.0 6.8 0.4 -1.4 -2.1 -2.1 -2.6 0.6 -2.0 -1.7 -1.8 -2.3 -2.3 -2.1 -2.2 -2.1 -0.5 0.7 -1.3 -1.2 -1.0
Alcohol intake versus 10 years previously 0.5 0.7 1.8 -1.0 -0.6 -0.3 -0.8 -0.8 -0.2 -0.9 -0.5 -0.7 -1.0 -0.8 -1.3 -1.0 -0.8 -0.9 -0.2 -1.4 1.1 -0.7
Father’s age at death 0.3 0.3 1.8 -1.4 0.2 0.5 0.1 0.4 0.4 0.1 -0.2 0.1 0.1 0.5 -0.3 -0.5 0.2 -1.2 -0.2 -0.3 1.3 0.1
Worrier / anxious feelings 0.4 0.8 3.1 -0.4 -0.7 0.2 -1.0 -0.9 -1.8 -0.8 -0.6 -1.1 -1.0 -0.2 -0.7 -0.8 -0.7 -0.8 1.7 -0.2 -0.6 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.2 1.8 -0.2 -0.6 0.1 -0.5 -0.0 -0.2 -0.9 -1.8 -0.1 -0.6 0.4 0.6 -0.1 1.6 -0.3 0.2 -1.8 0.2
Falls in the last year 0.4 0.5 1.5 1.0 0.7 0.8 1.1 0.5 0.5 0.4 0.8 0.2 0.4 0.9 0.5 0.7 0.8 -0.1 0.4 0.2 -0.8 1.2
Hair/balding pattern: Pattern 3 0.9 1.4 6.7 1.7 0.1 -0.3 1.0 0.6 0.0 0.4 0.5 -0.1 1.0 0.4 0.9 1.2 1.0 2.6 -1.9 0.7 -2.6 -0.0
Number of live births 3.1 4.4 10.3 -1.4 2.0 2.5 2.0 2.2 0.5 1.9 3.0 3.2 2.0 2.0 3.1 1.9 2.0 -0.1 2.1 2.4 0.8 2.0
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 5.0 -0.8 -0.7 -0.1 -1.0 -0.6 -2.2 -0.2 -1.6 -1.5 -0.1 0.6 -1.1 0.0 -0.5 -1.5 0.5 -0.5 0.2 -0.4
Pulse rate 0.4 0.6 1.8 1.2 -0.7 -0.8 -0.6 -0.8 1.1 -0.6 -0.7 0.6 -0.5 -0.8 -0.7 -0.5 -0.6 0.9 -1.0 -0.3 -1.4 -0.5
Happiness 0.6 0.7 2.0 -0.1 -1.3 -0.4 -1.4 -1.0 -0.3 -0.8 -0.9 -1.3 -1.0 -0.7 -0.8 -0.8 -1.1 -0.6 0.2 -0.6 -0.1 -0.9
Noisy workplace 1.0 1.3 4.8 -0.7 0.6 0.4 0.8 1.3 -0.6 1.2 2.2 1.8 1.2 1.1 1.1 1.2 1.0 -0.4 1.0 1.3 1.2 0.6
Qualifications: A levels/AS levels or equivalent 1.6 3.5 7.9 -1.2 1.9 1.9 1.8 2.5 -1.9 2.5 2.5 1.0 2.2 1.5 2.2 1.8 1.8 -0.6 -0.5 2.8 2.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 -1.5 0.7 0.6 0.8 1.2 0.0 0.7 0.8 0.3 1.1 1.1 0.5 0.8 0.7 -0.9 0.5 0.3 1.3 0.2
Mouth/teeth dental problems: Dentures 0.3 0.5 4.0 -0.4 0.2 -0.0 -0.3 -0.4 2.0 0.1 -0.9 0.3 -0.6 -1.1 -0.3 -0.8 -0.3 -0.6 -1.0 0.2 -0.1 0.0
Asthma 0.2 0.5 1.7 0.5 -0.3 -1.0 -0.4 0.0 1.2 0.1 -0.2 -0.3 -0.1 -1.0 -0.7 -0.1 -0.1 1.0 -1.3 0.1 -0.7 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 3.1 -1.2 -0.2 -0.4 -0.9 -0.5 -0.3 -0.0 0.2 -0.3 -0.7 -0.3 -1.1 -0.7 -0.8 -1.8 -0.7 0.2 1.2 -0.6
Medication: Cholesterol lowering 0.3 0.5 5.3 0.6 -0.3 -1.2 0.4 0.2 -0.2 -0.4 0.0 0.0 0.4 -0.4 0.1 0.2 0.1 1.3 -2.3 -0.1 -0.8 -0.5
Depression (self-reported) 0.6 0.7 2.2 0.2 -1.4 -1.1 -1.5 -0.9 0.1 -1.0 -0.8 -0.9 -1.1 -0.7 -0.6 -0.7 -0.9 0.6 0.8 0.1 -0.9 -0.9
Medication: Lansoprazole 0.3 0.3 1.7 -0.9 0.5 0.2 -0.0 0.1 0.1 0.6 0.4 1.3 -0.1 -0.1 -0.1 0.1 -0.0 -0.7 0.0 0.6 0.5 1.0
Prospective memory result 0.3 0.3 2.6 0.6 -0.1 -0.6 -0.7 0.1 0.1 0.2 0.1 -0.3 0.1 -0.5 -0.8 0.0 -0.2 0.4 -1.6 0.4 -0.7 -0.7
Lung cancer (father) 0.8 0.9 4.0 -1.2 0.8 0.6 0.3 0.4 -2.0 0.7 0.3 0.5 0.6 1.2 0.1 0.6 0.5 -1.9 1.4 0.1 0.4 1.4
Illnesses of mother 0.2 0.2 1.0 -0.7 -0.4 -0.1 -0.2 -0.4 -0.4 -0.3 0.4 -0.1 -0.4 -0.2 -0.9 -0.4 -0.4 -0.6 1.0 -0.2 0.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 4.7 -0.9 -0.2 0.4 -1.0 -0.5 -1.6 -0.1 -1.4 -1.3 -0.1 0.9 -0.7 -0.1 -0.3 -2.2 0.9 0.0 0.2 0.4
Pulse wave Arterial Stiffness index 1.4 1.6 4.1 -0.1 1.1 2.0 1.4 1.0 -0.4 1.4 2.0 1.4 1.0 1.5 1.1 1.3 1.0 -0.4 1.5 1.6 -0.8 1.3
Impedance of arm (left) 1.0 4.6 18.0 -1.8 2.1 2.1 1.5 1.9 -4.2 1.6 3.1 1.6 1.9 2.7 0.5 1.8 1.9 -1.6 2.6 1.7 0.9 2.6
Arm fat mass (right) 1.1 4.4 12.8 3.1 -2.0 -2.1 -1.0 -1.5 1.6 -2.1 -2.5 -1.5 -1.5 -2.4 -1.1 -1.1 -1.4 3.6 -2.7 -1.2 -3.0 -2.2
Trunk predicted mass 1.9 11.0 20.9 2.5 -4.4 -4.3 -2.9 -3.6 2.3 -4.1 -4.6 -2.4 -3.5 -2.9 -3.3 -3.4 -3.8 1.3 -0.2 -3.7 -2.0 -4.2
Standing height 1.2 11.7 24.5 1.3 -4.1 -4.6 -3.1 -3.9 -1.8 -4.4 -3.7 -2.2 -3.8 -2.0 -4.7 -3.8 -4.1 -0.8 2.8 -4.9 -1.1 -3.3
Length of working week for main job 0.2 0.2 0.8 0.6 0.3 0.2 0.3 0.0 -0.3 0.4 -0.4 -0.9 0.3 0.3 -0.1 0.7 0.1 0.0 -0.1 0.9 0.1 0.6
Exposure to tobacco smoke at home 3.4 3.9 6.9 -0.6 2.1 2.5 1.9 2.4 -1.4 2.4 2.1 2.0 2.2 2.2 2.6 2.1 2.3 -0.6 0.4 2.1 0.6 2.3
Breastfed as a baby 0.6 0.8 4.7 -0.5 0.8 1.1 0.3 0.0 -1.3 0.8 -0.0 -0.4 0.5 0.9 0.2 0.3 0.2 -2.2 0.6 1.0 -0.8 1.6
Tense / ‘highly strung’ 0.4 0.7 2.5 -0.5 0.6 0.8 0.8 0.8 -1.6 0.8 0.3 0.8 0.7 1.0 1.2 0.9 0.8 0.1 -0.4 1.5 0.2 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 8.4 -2.9 0.3 1.0 -0.6 0.4 -1.4 0.9 1.5 -0.3 -0.1 -0.0 -0.1 -0.2 -0.2 -1.9 0.6 2.2 2.0 -0.4
Hair/balding pattern: Pattern 4 0.2 0.5 2.2 0.0 -0.5 -0.5 -0.6 -0.4 0.0 -1.0 -0.4 0.6 -0.9 -1.0 -0.9 -1.0 -0.5 -0.3 -0.2 -1.5 1.0 -0.6
Birth weight of first child 2.6 4.8 8.5 -1.1 -2.2 -2.8 -2.4 -2.7 0.1 -2.2 -1.3 -2.4 -2.9 -2.2 -2.4 -2.6 -2.9 -2.3 1.1 -2.0 1.2 -2.5
Peak expiratory flow (PEF) 0.5 1.2 8.6 -0.2 -1.1 -0.9 -0.7 -0.6 -2.9 -0.4 -1.7 -1.7 -0.2 -0.6 -1.4 -0.1 -0.7 0.2 -1.0 -0.9 -0.3 -1.1
Pulse wave reflection index 0.4 0.5 2.5 -1.4 0.7 1.1 -0.0 0.2 0.0 0.9 0.9 -0.2 0.2 0.4 -0.1 0.1 0.1 -1.6 0.6 1.1 0.6 0.8
Ever highly irritable/argumentative for 2 days 2.3 2.8 5.8 0.5 -2.3 -2.2 -1.5 -1.6 1.9 -1.8 -2.3 -1.1 -1.6 -1.8 -1.2 -1.4 -1.8 0.7 -0.4 -2.2 -0.5 -2.4
Loud music exposure frequency 0.4 0.4 2.1 0.5 -0.5 -0.3 0.5 0.9 0.2 -0.2 -0.1 1.3 0.5 0.6 -0.0 0.2 0.5 1.4 0.5 -0.5 -0.6 -0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.5 0.6 1.0 0.7 1.3 1.5 1.0 1.2 0.8 0.9 1.4 0.6 1.6 1.1 1.3 0.7 -1.0 1.2 -0.2 0.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 7.7 0.7 0.4 0.6 1.2 1.0 -0.0 0.3 0.9 2.8 0.9 1.0 0.9 1.0 1.1 1.1 1.6 0.7 -0.1 0.5
Blood clot in the leg (DVT) 0.3 0.4 2.1 1.2 -0.2 -0.5 0.1 -0.1 -0.8 -0.6 -0.6 -0.4 0.1 0.4 0.0 0.3 0.2 1.4 0.4 -0.6 -1.2 -0.1
Medication: Paracetamol 0.2 0.4 1.3 -1.0 0.8 1.0 -0.1 0.5 -0.5 0.7 0.4 0.4 0.5 0.4 0.2 0.4 0.5 -0.5 -0.6 1.1 0.5 0.6
Headache pain in last month 0.9 1.6 3.5 1.2 1.4 1.2 1.9 1.4 0.3 1.1 0.4 1.3 1.6 1.0 1.5 1.6 1.5 1.4 0.3 0.9 -0.7 1.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.9 0.1 0.1 0.4 -0.7 -0.6 -0.9 0.2 -0.2 -1.7 -0.4 0.1 -0.2 -0.2 -0.3 -1.0 1.6 0.3 -0.4 0.3
Glaucoma (self-reported) 0.4 0.5 6.2 -0.9 -0.2 -0.1 0.1 -0.1 0.3 0.1 0.1 -0.4 -0.2 0.8 -0.1 -0.1 -0.2 -1.0 2.5 0.7 -0.1 0.2
Gout (self-reported) 0.3 0.5 2.3 1.3 -0.7 -1.3 -0.1 -0.2 0.1 -0.3 -0.6 0.2 -0.3 -0.6 -0.5 -0.2 -0.5 1.5 -0.2 -0.5 -0.6 -0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.8 1.2 0.8 0.8 0.3 0.8 -0.7 0.8 0.2 -0.3 0.7 -0.2 1.5 0.8 0.7 0.8 -0.9 1.7 -0.2 0.9
Medication: Amlodipine 0.6 0.8 3.5 -1.1 -0.4 -0.7 -0.6 -0.6 1.9 -0.6 -0.5 1.8 -0.7 -0.8 -0.7 -0.8 -0.6 -0.8 0.2 -0.4 0.7 -0.9
Medication: Ventolin 100micrograms inhaler 0.8 1.1 4.2 1.5 0.4 0.1 0.8 0.9 0.7 1.0 1.2 0.3 1.1 0.1 0.0 0.9 0.9 2.0 -2.1 0.5 -1.3 0.2
Birth weight 0.3 0.6 4.3 -0.2 -0.6 -0.8 0.2 0.0 -2.1 -0.0 1.0 1.4 -0.1 0.0 -0.0 -0.0 -0.4 -0.3 1.6 0.1 0.8 -0.8
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.2 -0.2 0.5 1.1 -0.5 0.1 0.8 0.2 -0.6 0.1 0.2 -0.3 0.2 0.2 0.3 -0.4 -0.6 0.6 0.1 0.4
High blood pressure (siblings) 0.5 0.7 2.2 0.1 0.6 1.1 1.1 0.9 0.6 -0.0 -0.2 1.5 0.7 0.5 1.1 0.6 0.9 0.8 1.4 -0.7 0.4 0.2
Forced vital capacity (FVC), Best measure 0.2 0.8 5.9 -0.8 -0.0 0.5 -0.6 -0.2 -1.1 -0.0 -1.1 -0.5 0.0 1.2 -0.3 -0.1 -0.2 -2.4 1.7 0.1 0.2 0.7
Body fat percentage 0.7 2.8 18.0 3.2 -0.2 -0.7 0.4 0.1 -0.1 -0.4 -0.5 -0.9 0.2 -1.0 0.4 0.8 0.4 4.2 -3.0 0.3 -3.3 -0.4
Leg fat percentage (right) 0.9 3.4 20.4 3.3 0.2 0.1 0.9 0.5 0.6 0.3 -0.3 -0.8 0.7 -0.7 1.3 1.4 0.9 4.5 -3.7 1.0 -3.3 -0.1
Arm fat-free mass (right) 1.9 9.8 17.3 3.3 -3.8 -4.2 -2.4 -3.2 2.0 -3.5 -4.1 -2.3 -3.1 -3.2 -2.9 -2.8 -3.3 2.5 -1.6 -3.6 -2.4 -3.7
Exposure to tobacco smoke outside home 1.2 1.6 3.9 1.2 1.2 0.7 1.4 1.4 -0.2 1.3 2.0 1.7 1.4 1.0 1.6 1.4 1.5 1.2 -0.5 0.7 -0.5 1.3
Comparative body size at age 10 0.2 0.4 2.4 0.3 0.2 -0.1 1.2 0.6 1.6 0.0 -0.1 -0.1 0.3 0.2 0.7 0.4 0.5 1.3 -0.1 -0.6 0.7 -0.2
Number of full brothers 1.2 1.5 2.8 1.0 0.9 1.1 1.5 1.7 0.2 1.3 1.4 1.7 1.3 0.8 1.5 1.4 1.4 1.3 0.8 1.4 -0.1 0.8
Worry too long after embarrassment 1.2 2.0 6.7 -0.9 -1.8 -1.0 -1.6 -1.3 -2.6 -1.4 -1.1 0.3 -1.5 -0.3 -1.8 -1.2 -1.5 -0.8 1.1 -1.6 1.3 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.6 -0.9 -0.6 -0.6 -1.7 -1.0 0.8 -0.8 -0.9 -1.1 -1.3 -1.9 -1.2 -1.5 -1.2 -0.5 0.0 -0.3 0.1 -0.7
Wheeze or whistling in the chest in last year 0.1 0.2 0.7 -0.2 -0.6 -0.5 -0.3 -0.2 0.1 -0.3 0.2 -0.0 -0.3 -0.7 -0.5 -0.2 -0.4 0.9 -0.4 0.0 -0.1 -0.6
Number of children fathered 0.4 0.4 1.7 -0.7 0.6 1.0 0.7 0.7 -0.4 0.8 1.3 -0.2 0.6 0.2 0.5 0.7 0.5 0.3 0.4 0.2 0.9 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 0.3 0.8 -0.3 0.6 1.0 -0.0 1.1 0.2 0.9 1.0 0.5 1.1 1.0 0.9 -0.0 -1.2 1.2 -0.6 0.7
Age at first live birth 0.3 0.5 1.6 0.6 -1.1 -1.3 -0.3 -0.7 0.4 -0.7 -0.8 -0.8 -0.7 -0.5 -1.1 -0.5 -0.9 -0.2 0.3 -0.8 -0.2 -1.0
Pulse wave peak to peak time 1.9 2.2 5.4 0.2 -1.5 -2.3 -1.6 -1.3 0.3 -1.8 -2.3 -1.6 -1.4 -1.6 -1.5 -1.5 -1.4 0.2 -1.2 -2.0 0.8 -1.6
Health satisfaction 0.5 0.6 3.7 1.8 -0.5 -0.8 -0.4 -0.8 0.3 -0.4 -0.3 -0.1 -0.5 -0.9 0.4 -0.2 -0.5 1.0 0.1 -0.4 -1.9 -0.1
Shortness of breath walking on level ground 0.3 0.4 2.4 0.0 -0.1 -0.5 -0.3 -0.5 -0.2 -0.0 0.3 1.0 -0.4 -0.6 -0.3 -0.4 -0.3 0.2 -1.6 0.4 -1.3 0.1
Qualifications: College or University degree 0.5 1.6 4.6 -1.1 -0.7 -1.0 -2.2 -1.4 -0.9 -0.6 -1.4 -2.0 -1.1 -1.2 -1.1 -1.3 -1.6 -1.8 0.0 -0.5 1.3 -1.1
Eye problems/disorders: None of the above 0.1 0.1 0.9 -0.2 0.1 0.2 0.0 0.2 -0.3 -0.0 0.4 -0.2 0.3 0.1 0.2 0.2 0.1 0.2 -1.0 -0.2 0.4 -0.3
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.4 -1.2 0.6 0.5 0.9 0.5 1.0 0.6 1.2 1.3 0.2 -0.1 0.5 0.1 0.3 -0.7 1.5 0.9 0.9 0.5
Emphysema/chronic bronchitis 1.8 2.0 4.2 1.5 1.2 0.9 1.8 1.2 1.2 1.0 0.7 1.8 1.3 1.1 1.7 1.7 1.6 1.8 0.1 1.4 -2.0 1.7
Medication for pain relief, constipation, heartburn 0.3 0.6 4.0 1.0 0.1 -0.2 0.1 -0.4 2.0 -0.2 -0.5 -1.3 -0.1 -0.4 0.3 -0.1 -0.1 0.8 0.8 0.1 -1.4 0.5
Neck or shoulder pain in last month 0.5 0.7 2.2 0.1 1.2 0.4 1.0 0.6 -1.3 1.2 0.7 -0.0 0.8 0.0 1.5 0.8 0.7 -0.3 -1.0 0.3 -0.1 1.0
Medication: Blood pressure 0.3 0.6 5.7 -0.6 -0.3 -0.2 0.5 0.2 0.8 -0.4 0.1 2.4 -0.1 -0.3 -0.2 -0.2 -0.1 0.3 -0.6 -1.1 1.2 -0.8
Angina (self-reported) 0.5 0.6 6.8 0.4 0.1 -0.1 0.1 0.2 1.5 -0.3 -0.3 0.5 0.1 -0.3 0.4 0.0 0.3 1.1 -2.6 -0.5 -0.3 -0.2
Migraine (self-reported) 0.3 0.4 1.5 -0.2 0.2 0.5 1.2 0.9 0.6 0.1 0.1 0.9 0.5 0.5 0.3 0.5 0.6 0.9 0.3 -0.4 1.2 0.0
Medication: Ibuprofen 1.0 1.2 4.9 -1.6 -0.7 -1.0 -1.2 -0.6 -0.6 -0.3 0.2 -0.5 -1.0 -0.8 -1.3 -1.2 -1.2 -2.2 -0.6 -0.0 1.9 -1.2
Medication: Allopurinol 1.4 1.9 6.4 0.8 -1.7 -2.5 -1.3 -1.1 -1.1 -1.1 -1.4 -1.0 -1.4 -1.8 -1.6 -1.2 -1.5 1.1 -1.0 -1.0 0.2 -1.6
Medication: Omeprazole 0.8 1.0 2.5 0.5 -0.9 -1.1 -0.7 -0.7 0.6 -1.1 -0.3 -1.2 -1.0 -1.5 -0.8 -1.0 -0.9 0.6 -1.3 -1.6 0.2 -1.5
Medication: Seretide 50 evohaler 1.4 1.6 3.9 1.2 -1.2 -1.5 -1.2 -1.5 2.0 -0.8 -1.0 -1.1 -1.2 -1.5 -1.2 -0.8 -1.2 0.9 -1.3 -0.0 -2.0 -1.3
Mean time to correctly identify matches 0.2 0.5 1.9 0.9 0.9 1.2 0.2 0.3 0.6 0.4 0.9 0.3 0.3 -0.0 0.0 0.1 0.5 0.1 0.5 1.2 -1.4 0.9
Heart disease (mother) 0.5 0.6 2.2 1.5 0.7 0.3 0.8 0.0 -0.3 0.1 -0.5 -0.2 0.3 -0.3 1.1 0.3 0.4 1.0 -1.3 0.2 -1.5 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.7 0.5 0.5 -0.3 0.6 0.0 -1.3 0.5 -0.2 -0.2 0.4 0.0 0.6 0.6 0.4 1.1 -0.4 1.0 -1.2 0.7
Whole body fat mass 0.9 4.0 16.3 3.3 -1.7 -2.0 -0.8 -1.2 0.6 -1.7 -2.0 -1.5 -1.1 -2.0 -0.9 -0.6 -1.0 4.0 -2.6 -0.9 -3.4 -1.8
Leg fat mass (right) 1.0 3.8 17.8 3.6 -1.3 -1.5 -0.3 -0.8 1.0 -1.3 -1.7 -1.4 -0.7 -1.8 -0.2 -0.2 -0.5 4.2 -3.4 -0.7 -3.4 -1.4
Arm predicted mass (right) 1.7 8.9 16.2 3.2 -3.5 -3.9 -2.3 -3.1 1.9 -3.3 -4.0 -2.3 -2.9 -3.0 -2.7 -2.7 -3.1 2.4 -1.6 -3.4 -2.5 -3.4
Pulse rate, automated reading 0.7 2.1 8.5 1.4 -1.1 -1.4 -1.5 -1.6 2.9 -1.4 -1.1 0.2 -1.6 -2.0 -1.9 -1.4 -1.4 0.6 -1.4 -0.6 -0.8 -1.1
Alcohol intake frequency. 0.3 0.7 3.3 0.9 -0.9 -1.1 -0.1 -0.6 1.5 -0.9 -0.8 -0.3 -0.7 -0.9 -0.3 -0.2 -0.6 1.8 0.5 -1.0 -0.3 -0.6
Comparative height size at age 10 1.7 9.4 16.8 1.0 -3.6 -3.8 -3.0 -3.8 -0.8 -4.1 -3.6 -1.9 -3.8 -2.2 -3.6 -3.8 -3.8 -0.8 2.0 -4.0 -0.9 -3.3
Number of full sisters 0.7 0.8 2.9 0.3 0.8 0.8 0.4 0.9 -0.6 1.3 1.7 1.0 0.9 0.2 0.7 0.8 0.6 0.1 0.3 1.5 1.3 0.9
Suffer from ‘nerves’ 1.8 2.8 5.5 -0.4 -2.0 -1.1 -2.4 -2.2 -2.2 -1.6 -1.6 -2.2 -2.1 -1.5 -1.8 -1.7 -2.1 -1.0 -0.4 -0.9 0.5 -2.1
Overall health rating 0.8 1.7 7.1 2.5 0.5 -0.1 1.7 0.6 0.6 0.2 0.4 0.9 0.8 -0.2 2.2 1.3 1.0 2.7 -2.0 -0.1 -1.6 0.3
Chest pain or discomfort 1.1 1.6 4.2 0.1 1.1 0.5 1.9 1.6 -0.9 1.0 0.9 2.1 1.6 1.8 1.6 1.6 1.6 0.8 -1.2 0.5 0.5 0.4
Had major operations 1.5 1.8 4.1 -0.4 -1.6 -1.4 -1.4 -1.6 0.6 -1.6 -0.5 -1.1 -1.5 -1.5 -2.0 -1.6 -1.6 -0.7 0.2 -1.9 0.0 -1.6
Age at last live birth 0.2 0.3 3.1 0.1 -0.5 -0.2 0.3 -0.2 0.8 0.2 0.3 0.1 -0.1 -0.0 -0.3 0.3 -0.4 -0.0 1.8 0.6 -0.3 -0.3
Family relationship satisfaction 0.8 1.0 2.7 0.5 0.7 1.4 0.7 0.9 0.4 0.9 0.7 0.5 1.1 1.6 1.1 1.2 1.1 0.1 1.1 1.6 -0.8 1.3
Leg pain on walking 0.7 0.8 4.6 1.2 0.7 -0.1 0.1 0.4 0.1 0.9 0.1 0.7 0.5 -0.8 0.5 0.5 0.4 1.0 -1.2 2.1 -1.8 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 7.6 0.4 -0.5 0.0 -0.1 -0.5 0.1 -0.7 -1.1 0.0 -0.6 -0.4 -0.3 -0.3 -0.4 0.4 2.8 -0.5 -0.8 0.3
Commuting to job workplace: Car/motor vehicle 1.1 1.2 4.4 1.9 0.7 0.7 1.5 1.0 0.2 1.1 0.3 -0.1 1.1 0.5 2.1 1.4 1.0 1.4 0.4 0.9 -1.0 1.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 1.7 0.8 -0.5 -0.8 -0.6 -1.0 -0.5 -0.8 -0.4 -0.8 -0.9 -1.3 -0.8 -1.2 -0.9 0.8 0.4 -0.5 -1.2 -0.3
Medication: Aspirin 0.4 0.5 2.1 0.6 -0.8 -0.9 0.1 -0.5 -0.5 -0.7 -0.1 0.5 -0.6 -0.6 -0.7 -0.3 -0.4 1.1 -1.1 -1.4 -0.2 -1.0
Supplements: Vitamin C 0.2 0.3 2.4 -0.6 0.4 -0.6 -0.1 -0.2 -0.4 0.5 -0.1 0.3 0.2 -0.1 -0.1 0.0 -0.3 -1.6 0.5 -0.6 0.4 0.5
Knee pain experienced in last month 0.6 1.0 2.7 0.9 -1.6 -1.5 -0.4 -0.7 -0.8 -1.6 -1.2 -0.9 -0.9 -0.4 -0.7 -0.6 -0.8 0.5 1.5 -0.8 -0.3 -1.2
Hypertension (Self-reported) 0.4 1.1 3.2 0.6 1.0 0.9 1.3 0.8 1.6 0.7 0.7 1.8 0.7 0.0 1.2 0.7 1.1 1.2 -1.6 0.7 -1.3 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.4 1.6 0.1 0.3 0.3 0.2 1.4 0.1 0.8 0.2 0.1 -0.6 0.7 0.5 0.4 1.2 0.3 0.6 -1.3 0.3
Illnesses of father: Heart disease 0.6 0.9 2.6 0.9 0.8 1.2 1.5 0.7 -0.9 0.4 0.6 1.1 0.7 0.3 1.0 0.9 0.9 1.6 0.1 0.1 -1.0 1.1
Illnesses of siblings: Diabetes 1.3 1.6 4.4 -0.2 -1.4 -1.7 -1.4 -0.9 0.3 -1.3 -1.1 -0.5 -1.4 -2.1 -1.7 -1.4 -1.3 0.8 -1.1 -1.2 0.8 -1.8
Smoking status: Previous 1.4 2.1 5.1 1.0 -1.8 -2.1 -1.3 -1.3 1.6 -1.4 -0.6 -1.3 -1.5 -2.3 -1.0 -1.4 -1.5 1.3 -1.3 -0.8 -1.5 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.9 0.5 -1.1 -2.0 -0.8 -0.7 -1.4 -1.3 -1.4 -0.8 -0.5 0.5 -1.1 -0.6 -0.8 -0.5 1.2 -1.6 -0.5 -0.5
Whole body fat-free mass 2.0 11.3 20.4 2.7 -4.3 -4.4 -2.9 -3.6 2.3 -4.1 -4.5 -2.4 -3.6 -3.2 -3.4 -3.4 -3.8 1.6 -0.6 -3.7 -2.1 -4.2
Leg fat-free mass (right) 2.0 10.6 18.7 2.6 -4.2 -4.3 -2.8 -3.4 2.4 -4.0 -4.2 -2.4 -3.4 -3.2 -3.3 -3.3 -3.6 1.6 -0.4 -3.6 -1.9 -4.0
Arm fat percentage (left) 0.5 2.1 12.2 2.6 -0.5 -0.6 0.2 -0.1 1.0 -0.5 -0.9 -1.1 -0.0 -1.2 0.2 0.4 0.1 3.5 -3.0 0.4 -2.6 -0.8
Average weekly red wine intake 1.0 1.4 5.8 -2.0 1.3 1.5 0.1 0.9 0.4 1.3 0.3 1.0 1.0 0.9 0.8 0.4 0.6 -2.2 -1.0 -0.2 2.4 0.6
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.4 0.1 -1.2 -0.8 -0.3 -0.6 0.7 -1.1 -0.6 -0.1 -0.8 -0.7 -0.3 -0.5 -0.6 0.6 -0.0 -0.7 0.0 -1.1
Mood swings 1.3 2.4 7.7 -0.6 1.1 1.9 1.4 2.1 -2.8 1.6 0.9 1.1 1.9 1.7 1.9 1.7 1.8 0.8 0.2 1.9 0.4 0.9
Loneliness, isolation 0.5 0.6 6.9 -1.0 0.2 0.4 0.4 0.5 -2.6 0.3 -0.4 0.7 0.5 0.8 0.6 0.4 0.4 -0.2 0.7 0.1 0.4 -0.1
Long-standing illness, disability or infirmity 0.2 0.2 1.8 0.5 0.4 -0.1 0.2 0.1 -0.4 0.2 -0.0 1.4 0.0 -0.9 0.4 0.0 0.1 0.8 -0.3 0.5 -0.2 0.1
Ever had bowel cancer screening 4.2 4.9 9.6 -1.0 -1.8 -2.0 -3.1 -2.6 0.5 -2.0 -2.5 -3.0 -2.6 -2.7 -2.4 -2.9 -2.7 -1.9 -2.0 -1.4 -0.8 -1.8
Diabetes diagnosed by doctor 0.3 0.4 1.9 0.0 -0.0 -0.8 0.9 0.7 0.6 0.0 -0.7 1.1 0.7 -0.1 0.5 0.2 0.5 0.8 -1.4 -0.6 0.3 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 5.8 0.8 -0.5 0.2 0.2 -0.2 1.9 -0.5 -0.3 1.0 -0.0 0.3 0.8 0.1 -0.0 1.1 2.4 -1.0 -1.0 -0.2
Friendships satisfaction 0.5 0.6 1.9 -0.3 0.8 1.4 -0.0 0.7 -1.2 1.0 0.5 -1.1 0.7 0.5 0.9 0.5 0.7 -0.8 -1.1 0.9 -0.0 0.6
Qualifications: nursing, teaching 0.3 0.5 1.5 0.6 0.9 0.0 0.6 0.6 0.8 0.6 0.6 -0.9 0.6 0.2 1.2 0.5 0.6 0.5 -0.2 1.1 -1.2 0.5
Commuting to job workplace: Walk 0.6 0.7 1.9 -0.5 -1.1 -1.0 -1.1 -0.7 -0.4 -1.0 -0.4 -0.5 -0.8 -1.1 -0.8 -1.3 -1.0 -0.4 -0.0 -0.5 -0.1 -1.4
Eye problems/disorders: Cataract 0.2 0.2 1.0 -0.2 0.2 0.5 -0.2 -0.2 0.4 0.2 -0.1 0.6 -0.2 -0.3 -0.1 -0.2 -0.1 -1.0 1.0 -0.2 0.3 0.5
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.0 1.1 0.8 1.2 1.0 1.2 -0.6 0.8 1.4 0.9 1.1 1.4 1.3 1.4 1.4 1.1 1.1 0.9 -0.3 1.2
Medication for cholesterol 0.6 1.0 5.4 -0.1 -1.1 -1.3 -0.8 -0.5 -1.5 -1.1 -0.5 -0.3 -0.4 0.2 -1.5 -0.5 -0.6 -0.6 2.3 -1.3 -0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 8.2 -1.8 0.2 -0.3 -1.0 -0.3 0.2 0.0 -0.8 0.1 -0.6 -1.0 -0.2 -1.3 -0.7 -2.9 -1.1 -0.6 1.0 -0.5
Back pain experienced in last month 0.8 1.2 3.9 2.0 -1.0 -1.4 -0.7 -1.2 0.8 -1.3 -0.6 0.1 -1.3 -1.4 -0.8 -1.0 -1.1 1.0 0.2 -1.2 -0.9 -0.9
Mineral and other dietary supplements 0.8 1.0 4.4 1.6 -0.3 0.4 1.0 1.3 -0.5 0.3 1.4 1.9 1.0 0.6 -0.0 0.8 0.8 2.1 -0.6 0.2 0.3 -0.4
Breast cancer (self-reported) 4.3 5.2 14.4 1.2 -2.4 -2.8 -2.4 -2.6 0.6 -2.6 -3.8 -3.4 -2.5 -2.4 -2.0 -2.3 -2.4 0.5 -0.1 -1.8 -1.9 -1.8
Asthma (self-reported) 0.2 0.4 1.6 0.4 -0.4 -0.9 -0.2 0.2 1.0 0.1 -0.1 0.1 -0.0 -0.8 -0.7 -0.0 -0.0 1.3 -1.3 0.1 -0.6 -0.9
Osteoporosis (self-reported) 0.6 0.7 1.9 0.9 -0.2 0.1 -0.8 -1.1 1.1 -0.9 -0.9 -0.9 -1.0 -1.2 -0.6 -0.8 -0.7 0.6 0.4 -0.9 -1.4 0.0
Osteoarthritis (self-reported) 3.8 4.9 8.8 0.9 -2.8 -2.5 -2.6 -2.5 1.2 -2.8 -3.0 -0.9 -2.7 -2.3 -2.8 -2.2 -2.6 0.3 -0.7 -2.4 0.2 -2.9
Medication: Aspirin 0.3 0.4 1.6 0.0 -0.8 -0.9 0.1 -0.4 -0.5 -0.6 0.1 0.6 -0.5 -0.4 -0.7 -0.3 -0.4 0.7 -0.4 -1.3 0.0 -0.9
Medication: Gliclazide 0.6 0.7 2.6 -0.4 -0.8 -0.7 -0.6 -0.5 0.4 -1.0 -0.8 0.1 -0.8 -1.0 -0.8 -1.1 -0.8 -0.7 0.1 -1.6 1.4 -0.9
Illnesses of father: None of the above (group 1) 0.4 0.5 1.9 0.9 0.3 0.1 0.5 0.3 -1.2 0.5 0.0 -1.1 0.5 1.0 0.5 0.6 0.5 0.1 0.7 1.4 -0.6 0.4
Smoking status: Current 5.7 9.1 13.4 -1.9 3.5 3.7 3.0 3.3 -3.2 3.4 3.5 3.4 3.3 3.2 3.2 2.8 3.3 -0.8 1.9 3.1 2.0 3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.2 -1.0 0.5 1.1 -0.6 -0.1 -1.4 0.6 -1.4 -1.8 0.2 0.5 0.0 0.3 0.2 -1.4 -0.5 1.1 0.6 0.8
Whole body water mass 2.0 11.5 21.2 2.9 -4.4 -4.5 -3.0 -3.6 2.4 -4.2 -4.6 -2.4 -3.6 -3.3 -3.3 -3.4 -3.8 1.7 -0.6 -3.6 -2.3 -4.1
Leg predicted mass (right) 1.9 9.9 17.8 2.5 -4.1 -4.2 -2.8 -3.2 2.2 -3.9 -4.2 -2.3 -3.3 -3.1 -3.2 -3.2 -3.5 1.5 -0.4 -3.5 -1.9 -4.0
Arm fat mass (left) 1.0 4.0 13.0 3.1 -1.9 -2.0 -0.9 -1.4 1.4 -1.8 -2.4 -1.4 -1.3 -2.2 -1.0 -0.9 -1.2 3.6 -2.8 -0.9 -2.9 -2.0
Number of self-reported non-cancer illnesses 0.2 0.3 3.0 0.7 -0.4 -0.4 0.2 0.2 0.8 -0.5 -0.1 0.3 -0.2 -0.6 0.4 0.1 0.1 1.7 -0.4 -0.1 -0.2 -0.7
Average weekly champagne plus white wine intake 0.9 1.2 3.1 1.8 0.6 -0.2 1.3 1.1 -0.0 0.9 1.6 1.6 1.2 0.5 1.5 1.4 1.0 1.5 -0.5 0.9 -0.3 0.5
Miserableness 3.7 6.4 12.2 -0.2 2.4 2.3 2.3 3.3 -2.4 3.3 3.5 2.0 3.3 2.5 3.0 3.3 2.9 0.7 -0.4 3.3 0.7 2.2
Guilty feelings 0.8 1.2 10.0 -1.0 0.3 0.4 0.2 0.8 -3.2 0.7 1.0 1.7 0.7 0.6 0.2 0.5 0.4 -0.2 1.6 0.6 1.3 -0.3
Wears glasses or contact lenses 0.5 0.6 3.4 0.4 0.6 0.6 0.5 0.4 -0.2 0.5 0.1 -0.5 0.5 0.3 0.3 0.8 0.5 1.1 -1.3 1.9 -1.1 0.3
Ever taken oral contraceptive pill 2.6 2.9 6.2 0.4 2.2 1.9 1.5 1.7 -1.9 2.3 2.1 2.0 1.8 1.4 1.5 1.7 1.7 -0.3 -0.5 1.9 0.4 2.5
Hearing aid user 1.9 2.2 3.6 0.7 1.4 1.5 1.8 1.9 0.7 1.7 1.4 1.6 1.8 0.6 1.7 1.8 1.9 1.9 -1.3 0.7 -0.5 1.7
Mother’s age at death 3.7 4.7 9.6 1.8 -2.2 -2.6 -2.1 -2.4 -0.2 -2.2 -1.9 -3.1 -2.2 -2.6 -2.3 -2.1 -2.2 1.3 -1.5 -2.4 -1.7 -2.6
Financial situation satisfaction 2.2 2.8 5.9 0.8 1.4 2.0 2.1 1.1 -1.4 1.3 0.3 1.6 1.8 2.4 2.0 2.2 1.7 0.3 0.8 1.2 -2.2 2.4
Tinnitus: Yes, now most or all of the time 0.7 0.8 3.0 0.3 -0.6 -0.6 -0.6 -1.4 -0.0 -0.7 -1.3 -0.9 -1.3 -1.7 -0.6 -0.9 -0.9 0.7 -0.7 -0.3 -1.3 -0.7
Commuting to job workplace: Public transport 1.5 1.8 4.5 -0.9 -1.1 -1.5 -1.6 -1.6 -0.3 -1.3 -1.9 -0.8 -1.5 -0.8 -2.1 -1.6 -1.5 -1.7 -1.0 -1.3 0.4 -1.1
Eye problems/disorders: Glaucoma 0.5 0.6 4.3 0.3 -0.6 -0.6 -0.4 -0.9 0.7 -0.4 -0.8 -1.2 -0.7 -0.2 -0.5 -0.3 -0.7 0.2 2.1 0.4 -1.2 0.1
Medication: Blood pressure 0.5 1.0 4.6 -0.1 0.9 0.6 0.9 0.4 2.2 0.9 0.2 0.8 0.4 -0.4 1.5 0.4 0.7 0.7 -1.7 1.4 -1.4 0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.3 5.5 0.8 1.3 0.7 0.7 0.6 0.1 1.4 0.6 1.2 1.2 0.3 1.3 1.4 0.9 0.4 -0.7 2.0 -2.3 1.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 -0.8 0.9 0.4 -0.1 -0.3 -0.1 0.3 -0.5 -0.8 0.1 0.2 0.8 0.3 0.2 -1.0 0.3 1.0 -0.7 1.2
High cholesterol (Self-reported) 0.5 0.8 6.2 0.2 0.6 0.0 1.0 1.1 -1.5 0.5 0.3 -0.1 1.0 0.3 0.3 0.8 0.9 1.1 -2.5 0.7 0.2 0.2
Medication: Bendroflumethiazide 0.6 0.9 3.8 -0.3 0.9 1.1 0.9 0.4 1.9 1.0 0.9 0.7 0.6 0.2 1.1 0.8 0.7 0.6 -1.6 1.1 -0.2 0.7
Medication: Paracetamol 0.1 0.2 1.1 -0.6 0.2 0.6 -0.2 0.1 -0.8 0.4 0.2 0.0 0.3 0.4 -0.0 0.4 0.2 -0.6 -0.6 1.1 0.2 0.3
Medication: Lisinopril 0.3 0.4 2.7 0.6 0.4 0.5 0.7 0.3 0.4 -0.3 -0.2 0.7 0.3 0.1 0.5 0.3 0.5 1.5 -0.2 0.0 -1.6 0.4
Medication: Atorvastatin 1.0 1.2 2.4 0.4 0.8 0.6 1.5 1.4 -1.3 0.9 1.2 1.5 1.2 1.3 1.1 1.3 1.3 0.8 -0.3 1.0 0.9 0.6
Illnesses of father: High blood pressure 0.5 0.6 3.0 -0.9 0.5 1.2 0.7 0.5 1.4 0.1 -0.1 -0.1 0.6 0.8 1.1 0.6 0.8 0.1 -1.7 0.1 -0.2 0.5
Alcohol drinker status: Never 0.6 0.8 6.4 1.1 0.9 0.9 0.3 0.5 2.5 0.6 1.2 0.1 0.4 -0.2 0.8 0.5 0.6 1.1 -0.2 0.1 0.5 0.6
Ever smoked 0.2 0.3 1.8 -1.2 -0.0 0.3 0.4 0.5 -0.4 0.4 1.4 0.6 0.4 0.4 0.3 0.1 0.2 -0.6 -0.0 0.8 0.2 0.2
Basal metabolic rate 1.8 9.9 17.5 3.0 -4.0 -4.1 -2.6 -3.2 2.1 -3.8 -4.2 -2.2 -3.2 -3.0 -3.0 -3.0 -3.4 2.2 -0.9 -3.4 -2.4 -3.9
Leg fat percentage (left) 0.9 3.3 22.9 3.2 -0.0 -0.1 0.8 0.5 0.8 0.0 -0.3 -1.0 0.5 -0.8 1.2 1.2 0.8 4.8 -3.3 0.6 -3.3 -0.3
Arm fat-free mass (left) 2.0 10.0 18.5 3.3 -3.9 -4.1 -2.5 -3.3 2.3 -3.6 -4.3 -2.1 -3.1 -3.2 -2.8 -2.9 -3.3 2.5 -1.8 -3.4 -2.7 -3.7
Number of operations (self-reported) 1.5 2.2 5.0 -1.0 -1.7 -1.1 -1.6 -1.8 0.9 -1.6 -0.5 -2.0 -1.9 -1.6 -2.2 -1.7 -1.8 -1.1 -0.3 -1.3 0.1 -1.5
Average weekly beer plus cider intake 0.3 0.4 1.5 -1.2 0.1 0.2 0.1 -0.2 -0.7 0.3 1.2 -1.1 -0.0 1.1 -0.0 0.5 0.1 -1.2 0.5 0.1 0.7 0.3
Irritability 0.7 1.1 3.1 0.9 -1.1 -1.4 -0.4 -0.3 -1.3 -0.8 -1.0 -1.3 -0.6 -1.2 -1.2 -0.5 -0.7 1.8 -1.1 -0.9 -0.1 -1.6
Risk taking 0.7 1.0 4.5 -0.5 0.8 0.7 1.0 1.2 1.2 1.2 0.3 2.1 1.2 1.1 1.2 0.8 0.9 -0.1 0.5 1.2 0.1 0.9
Ever had prostate specific antigen (PSA) test 2.3 2.6 9.2 1.0 -1.6 -2.1 -2.0 -2.1 3.0 -1.6 -1.1 -0.7 -1.8 -1.9 -1.0 -1.5 -1.9 0.2 1.2 -1.4 -1.1 -1.1
Fractured/broken bones in last 5 years 1.3 1.7 12.6 0.6 -1.1 -1.4 -0.6 -1.0 3.5 -1.2 -2.1 -0.5 -0.9 -1.2 -0.5 -0.9 -1.1 0.1 -1.2 -1.2 -0.5 -0.9
Age started oral contraceptive pill 1.3 1.7 6.5 -1.3 0.2 -0.5 -0.9 -1.0 -1.6 0.0 -1.0 -1.2 -1.1 -1.3 -1.5 -1.4 -1.0 -2.3 -2.5 -1.2 1.1 -0.4
Diastolic blood pressure, automated reading 0.6 1.8 8.2 2.0 0.9 1.1 0.4 0.2 2.7 0.7 0.0 -0.4 0.6 -0.6 1.1 0.7 0.7 1.9 -1.7 0.8 -2.9 1.2
Ever depressed for a whole week 0.5 0.6 3.2 0.8 -1.2 -0.9 -0.5 -0.3 -0.4 -0.7 -0.6 -0.3 -0.5 -0.4 -0.6 -0.1 -0.5 1.5 0.5 -0.0 -1.8 -1.0
Unable to work because of sickness or disability 2.3 3.0 4.7 -1.4 2.2 2.0 2.0 2.0 -0.8 2.0 2.0 2.0 2.0 1.8 1.7 1.6 1.9 -0.5 0.9 2.0 0.9 1.8
Commuting to job workplace: Cycle 1.4 1.6 4.9 -1.6 1.2 1.1 0.8 1.5 -1.0 1.4 1.7 2.2 1.2 1.7 0.4 0.7 1.0 -1.8 0.8 0.8 0.9 0.9
Myopia 0.4 0.6 2.0 0.7 -0.7 -0.4 -0.8 -0.1 1.4 -0.6 -0.3 -1.3 -0.2 -0.7 -0.7 -0.3 -0.2 1.3 -0.0 -0.5 -0.8 -0.9
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.9 -0.5 -1.1 -1.0 -1.6 -1.1 -1.4 -0.8 -0.9 -2.0 -0.9 -0.1 -1.4 -0.9 -1.2 -1.5 1.8 -0.9 1.1 -0.7
Cholesterol lowering medication 0.7 1.0 10.3 1.0 0.4 -0.3 0.7 0.7 0.5 0.2 -0.4 -0.7 0.4 -0.9 0.1 0.2 0.5 2.1 -3.2 -0.4 0.2 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.8 -0.6 -0.6 -0.7 -0.7 -0.6 0.4 -0.8 -0.6 -0.4 -0.9 -0.7 -0.4 -0.9 -0.8 -1.0 -0.5 -1.4 1.0 -1.2
Pain experienced in last month 0.7 1.1 5.1 -2.3 -0.8 -0.4 -1.3 -0.8 0.3 -0.6 -0.6 -1.2 -0.8 -0.6 -1.4 -1.2 -0.9 -1.4 -0.4 -0.1 1.6 -0.8
Supplements: Calcium 4.8 5.3 9.4 0.5 -2.2 -2.3 -3.0 -3.0 1.2 -2.5 -2.9 -3.1 -2.7 -2.7 -2.5 -2.7 -2.8 -0.3 0.8 -1.6 -1.7 -2.0
Basal cell carcinoma (self-reported) 1.4 1.7 3.6 0.3 1.5 1.3 1.9 1.3 -1.3 1.3 1.4 1.7 1.2 1.5 1.6 1.5 1.4 0.5 -0.3 0.8 -0.3 1.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 3.8 -0.3 0.1 0.3 0.2 0.3 -1.5 0.0 0.3 1.8 0.4 0.6 -0.2 0.3 0.4 0.2 -2.0 -0.8 0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.9 1.1 -0.3 -0.4 0.0 -0.3 -0.4 -0.7 -0.7 -0.7 -0.1 0.2 -0.2 0.1 0.1 1.4 0.5 -0.5 -1.2 -0.1
Heart disease (siblings) 0.4 0.5 3.9 1.0 -0.6 -0.6 0.2 -0.3 0.5 -0.5 -0.9 -0.4 -0.3 -0.7 0.5 0.1 -0.3 2.0 -0.2 -0.6 -0.5 -0.7
Alcohol drinker status: Previous 0.2 0.2 0.7 -0.8 -0.6 -0.2 -0.6 -0.5 0.7 -0.2 -0.7 0.1 -0.5 -0.4 -0.1 -0.4 -0.6 -0.3 0.4 -0.0 0.4 -0.5
Pack years of smoking 0.2 0.4 1.9 -0.7 0.5 0.5 -0.0 -0.2 0.3 0.7 -0.5 1.0 0.1 -0.1 0.3 0.1 0.0 -1.2 -0.7 0.5 1.4 0.1
Impedance of whole body 1.3 6.8 23.5 -1.4 2.9 2.6 2.3 2.5 -4.8 2.5 3.6 2.0 2.6 3.1 1.4 2.7 2.7 -0.7 2.0 1.8 0.6 3.4
Leg fat mass (left) 1.0 4.1 19.3 3.6 -1.4 -1.6 -0.4 -0.9 1.1 -1.4 -1.8 -1.5 -0.8 -2.0 -0.3 -0.3 -0.7 4.4 -3.2 -0.9 -3.4 -1.6
Arm predicted mass (left) 2.2 11.2 21.2 3.4 -4.1 -4.3 -2.7 -3.5 2.5 -3.9 -4.6 -2.4 -3.4 -3.5 -3.0 -3.1 -3.5 2.5 -1.5 -3.5 -2.7 -3.9