Hub : Genes

CDC42BPG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0711	0.0266	1.3e-06	0.059	0.044	0.061	0.047	0.059	3.1e-09	3.4e-07	2.0e-09	1.1e-07	3.0e-09
2	TCGA	Brain Lower Grade Glioma	0.0823	0.0376	1.5e-04	0.001	0.029	0.018	NA	0.012	2.0e-01	2.5e-04	3.3e-03	NA	1.3e-02
3	TCGA	Lung Squamous Cell Carcinoma	0.0312	0.0190	8.0e-03	0.001	0.012	0.005	NA	0.001	2.0e-01	1.4e-02	7.5e-02	NA	2.1e-01
4	TCGA	Thyroid Carcinoma	0.0390	0.0210	3.0e-03	0.010	0.020	0.018	NA	0.018	3.4e-02	4.5e-03	6.2e-03	NA	7.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.6	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.7	1.7	6.8	-2.6	0.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.5	1.0	3.3	-0.0	-0.3	1.8	-0.8
Depression (Nagel 2018)	0.1	0.2	0.4	0.2	0.5	0.4	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	-1.0	1.0	0.1	0.2
Neuroticism (Nagel 2018)	0.5	1.1	2.3	0.4	0.2	1.5	-1.5
Schizophrenia (2018)	1.7	3.4	6.7	-2.6	-2.3	0.4	1.3
Schizophrenia vs Biploar Disorder	1.0	1.3	5.2	2.3	0.0	0.0	0.0
Worry (Nagel 2018)	0.2	0.4	1.0	0.2	0.1	0.8	-1.0
Alzheimer’s Disease (in mother)	0.9	1.1	1.8	-1.3	-0.7	-0.5	1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.3	-0.1	-0.7	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	-0.8	-0.0	-0.9	0.7
Crohns Disease (2017)	0.9	1.9	5.4	0.9	0.6	-2.3	1.0
Irritable Bowel Disease (IBD)	0.6	1.5	3.8	0.3	0.0	-2.0	1.4
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.5	-0.2	-0.4	0.9
Major Depression (MDD)	0.2	0.2	1.0	1.0	0.0	0.0	0.0
Reaction Time	0.3	0.5	0.9	-0.1	-0.8	-0.9	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.4	-0.2	2.1	0.5	-0.5
Breast Cancer	1.9	4.6	10.0	-1.9	0.7	-2.1	3.2
Ovarian Cancer	2.6	3.4	4.9	2.2	1.2	1.6	-2.1
Prostate Cancer	0.2	0.3	0.6	0.2	-0.6	0.8	0.6
Age at First Birth	2.1	3.0	5.2	1.4	1.9	1.2	-2.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	-1.0	-0.5	0.8	1.1
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.9	0.0	0.0	0.0
Crohns Disease (2012)	1.4	2.3	7.3	0.3	-0.1	-2.7	1.3
Mean Putamen Volume	0.7	0.8	1.4	-1.2	-0.6	1.2	-0.2
Fasting Glucose	0.2	0.2	0.6	0.4	-0.8	0.0	-0.5
HbA1C	0.4	0.4	1.2	0.0	-1.1	-0.6	-0.2
HDL Cholesterol	2.6	4.4	7.0	2.2	2.3	-0.9	-2.6
LDL Cholesterol	0.2	0.3	0.6	-0.8	0.5	0.3	0.2
Lupus	0.6	0.9	1.9	1.1	0.5	0.4	-1.4
Neuroticism (2016)	1.4	2.0	4.1	1.2	1.6	-0.0	-2.0
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.6	0.9	-0.7	-0.6
Rheumatoid Arthritis	2.2	3.0	5.8	2.4	0.8	0.7	-2.3
Schizophrenia (2014)	0.4	1.0	3.9	-2.0	0.0	0.0	0.0
Triglycerides	0.6	1.0	2.4	-0.8	-1.6	0.7	0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.4	-1.8	0.0	0.0	0.0
Ulcerative Colitis	0.5	0.7	1.2	-1.0	-1.1	-0.4	0.7
Blood Eosinophil Count	0.1	1.1	3.3	-0.9	1.8	-0.4	-0.3
Blood Platelet Count	0.2	2.7	8.0	1.0	-0.3	1.4	-2.8
Blood Red Count	0.2	1.7	3.1	-1.3	1.0	1.8	-1.1
Blood White Count	0.4	2.8	10.4	0.1	3.2	0.8	-0.6
Heel T-Score	0.2	1.3	3.1	-0.7	-1.8	-0.1	1.3
BMI	2.5	14.7	22.8	-4.8	-4.1	1.1	4.2
Height	0.7	12.9	28.5	5.3	3.3	-0.2	-3.5
Waist Hip Ratio (WHR)	0.6	2.8	4.5	-0.9	-2.1	1.6	1.8
Systolic Blood Pressure	0.1	0.7	1.3	-0.7	1.1	1.1	-0.1
Smoking Status	0.6	1.5	3.2	1.8	-0.5	0.9	-1.3
Allergy or Eczema	0.7	1.8	6.6	0.6	0.6	-2.6	0.3
Cardiovascular Disease	0.3	1.1	2.8	-1.1	-1.7	0.0	0.7
Hypothyroidism (self reported)	0.6	1.3	2.4	-1.3	-1.5	-0.7	0.9
Respiratory disease	0.6	1.4	4.4	0.7	-0.1	-2.1	0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	-0.8	1.5	0.8	0.4
Lung FEV1/FVC ratio	0.2	1.2	3.7	0.5	-0.1	1.9	-0.9
Lung FVC	0.8	4.1	11.4	1.7	0.8	1.2	-3.4
Neuroticism	0.3	0.8	2.1	0.4	0.6	0.6	-1.5
Chronotype (morning person)	0.9	2.1	5.7	1.3	0.8	-2.4	0.5
Hair Pigment	0.3	7.6	17.5	3.3	1.5	-4.2	-0.1
Tanning	0.0	0.3	0.4	-0.1	-0.6	-0.5	0.6
Hand grip strength (left)	0.3	0.9	2.0	-0.3	1.4	-1.1	-0.6
Number of treatments/medications taken	1.1	2.0	5.1	-1.0	-1.1	-0.7	2.3
Average weekly spirits intake	0.5	0.6	2.0	0.3	0.1	1.4	-0.3
Sensitivity / hurt feelings	0.5	0.9	1.3	1.1	-1.0	-0.8	-0.7
Frequency of depressed mood in last 2 weeks	1.3	1.9	3.3	0.2	1.8	1.1	-1.8
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.5	-1.3	-0.1	-0.8
Relative age of first facial hair	1.7	3.4	11.4	-1.2	-0.9	3.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	-0.1	0.4	1.4	-0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.0	1.1	-1.0	-1.4	-0.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.3	-0.9	-0.3	0.5
Systolic blood pressure, automated reading	0.6	1.6	2.7	-1.6	-0.2	1.2	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	0.5	-0.1	-0.2	-1.2
Angina	0.4	0.5	0.8	-0.8	-0.9	0.6	0.4
Medication for hormone replacement therapy	0.3	0.4	1.2	1.1	-0.2	-0.5	-0.3
Vitamin and mineral supplements	0.5	0.7	1.4	-1.0	-0.5	0.4	1.2
Supplements: Zinc	0.1	0.1	0.4	-0.0	0.2	-0.6	0.4
Medication: Co-codamol	0.5	0.6	0.7	0.7	0.8	0.7	-0.8
Medication: Metformin	0.1	0.1	0.4	-0.4	0.2	-0.0	0.6
Diabetes (father)	1.2	1.5	4.5	0.5	2.1	-0.5	-0.9
Diabetes (mother)	2.6	3.4	5.8	-1.9	-2.4	1.6	1.3
Severe depression (siblings)	0.1	0.1	0.3	-0.0	-0.5	-0.0	0.4
Pack years adult smoking proportion	1.8	2.7	5.5	-1.4	-2.3	0.4	1.8
Impedance of leg (right)	0.4	2.1	3.4	1.8	1.7	-0.1	-1.5
Leg fat-free mass (left)	0.0	0.2	0.3	-0.5	0.3	0.6	-0.2
Trunk fat percentage	0.6	2.6	4.6	-2.1	-0.8	1.5	1.7
Hand grip strength (right)	0.3	0.7	1.6	-0.8	1.3	-0.8	-0.1
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.1	-0.5	0.6	0.4
Current tobacco smoking	0.7	1.2	3.5	0.0	-1.9	1.1	0.1
Average weekly fortified wine intake	0.9	1.1	2.8	-1.1	0.2	1.7	-0.5
Maternal smoking around birth	0.8	1.2	1.8	0.9	1.2	1.4	-0.9
Fed-up feelings	0.2	0.3	0.8	-0.4	0.3	0.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-1.1	-0.6	0.3	0.8
Relative age voice broke	0.6	1.0	2.8	-0.8	0.4	1.7	0.5
Taking other prescription medications	0.1	0.1	0.3	0.1	0.2	0.5	0.3
Age when periods started (menarche)	0.2	0.4	0.8	-0.4	0.4	0.6	0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	-0.6	-1.2	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.4	-0.3	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	4.6	1.7	1.0	0.7	-2.1
Qualifications: CSEs or equivalent	0.6	0.8	2.0	1.0	0.3	-1.4	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	2.3	-0.1	1.5	0.5	-0.1
High blood pressure	0.3	0.7	1.3	-1.1	-1.1	-0.1	0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.5	0.7	0.3	-1.9	-0.5
Multivitamins +/- minerals	0.5	0.6	1.2	0.7	0.6	-1.1	-0.7
Stomach or abdominal pain in last month	0.9	1.1	3.0	0.8	0.7	-1.7	-0.7
Supplements: Glucosamine	0.1	0.1	0.2	0.4	-0.1	-0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.5	0.2	0.2	-1.1
Medication: Atenolol	0.2	0.3	0.6	-0.6	-0.8	-0.0	0.4
Medication: Levothyroxine sodium	0.8	1.3	3.2	-0.6	-1.8	1.3	0.2
Sitting height	1.2	8.7	18.0	2.4	4.2	-1.1	-3.2
Chronic bronchitis/emphysema (father)	1.3	1.5	3.7	-0.9	-1.9	0.1	1.2
High blood pressure (mother)	0.2	0.3	0.5	0.7	-0.2	-0.4	-0.7
Body mass index (BMI)	2.1	9.0	14.5	-3.8	-3.0	0.9	3.4
Impedance of leg (left)	0.6	3.1	5.5	2.4	1.9	-0.3	-1.8
Leg predicted mass (left)	0.0	0.2	0.4	-0.6	0.2	0.6	-0.2
Trunk fat mass	0.4	1.9	3.6	-1.9	-0.7	1.3	1.4
Waist circumference	0.8	2.9	4.9	-2.2	-1.5	1.5	1.5
Number of incorrect matches in round	0.4	0.6	1.6	0.6	-1.3	0.6	0.4
Past tobacco smoking	1.0	1.8	4.3	-2.1	-0.8	-0.6	1.4
Alcohol usually taken with meals	0.7	1.1	2.8	0.9	0.4	-1.7	-0.8
Nervous feelings	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.9	0.8	1.2	1.6	-2.4
Hearing difficulty/problems with background noise	0.5	0.7	2.0	0.4	-0.3	0.8	-1.4
Hair/balding pattern: Pattern 2	3.7	4.7	5.1	-1.9	-2.2	2.2	2.2
Had menopause	0.3	0.3	1.1	0.2	-0.4	1.0	0.2
Had other major operations	0.3	0.3	0.5	0.2	0.7	0.5	-0.7
Forced vital capacity (FVC)	2.6	9.9	16.6	3.1	3.7	-0.3	-4.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.2	-0.1	1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.9	1.2	1.4	-1.4	-0.9
Qualifications: None of the above	0.9	1.8	2.6	-1.2	-1.3	1.2	1.6
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.3	0.6	0.1	-0.4
Mouth/teeth dental problems	0.5	0.8	1.5	0.1	1.2	-1.1	0.6
Heart attack	0.2	0.3	0.8	-0.5	-0.1	0.1	0.9
Allergy	0.6	1.3	4.4	-0.6	-0.2	2.1	-0.8
Pain all over the body in last month	0.2	0.2	0.6	-0.8	-0.2	0.3	-0.1
Diabetes (self-reported)	0.4	0.7	1.1	-0.9	0.2	1.0	0.8
Hayfever/allergic rhinitis (self-reported)	2.8	3.6	6.1	-1.3	-2.5	-1.0	2.4
Medication: Ramipril	0.1	0.2	0.2	-0.5	0.3	-0.3	0.5
Medication: Simvastatin	0.4	0.6	1.9	1.4	-0.3	-0.6	-0.1
Fluid intelligence score	0.7	1.5	3.4	-1.3	1.9	0.9	0.1
Illnesses of siblings	1.6	2.2	6.1	-0.3	1.0	2.5	-1.3
Neuroticism score	0.6	1.3	3.5	-0.0	0.3	1.3	-1.9
Weight	0.2	1.1	2.4	-1.5	-0.6	0.9	1.0
Impedance of arm (right)	1.7	7.7	15.5	1.9	3.9	1.7	-3.0
Arm fat percentage (right)	1.4	5.4	11.6	-3.4	-1.5	1.3	2.5
Trunk fat-free mass	0.1	0.5	0.8	0.7	0.5	-0.6	-0.9
Hip circumference	0.3	1.4	3.5	-1.5	0.2	1.9	0.1
Time employed in main current job	0.6	0.7	1.1	0.8	0.5	-0.9	-1.0
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.3	-0.9	0.7	-0.6
Father’s age at death	1.0	1.3	2.3	0.8	1.2	0.9	-1.5
Worrier / anxious feelings	0.5	1.0	2.8	0.8	0.0	0.7	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.6	-0.6	1.2	1.3	-1.0
Falls in the last year	0.5	0.7	1.6	1.3	0.7	0.2	-0.9
Hair/balding pattern: Pattern 3	1.6	2.4	6.7	0.4	2.6	-1.2	-1.2
Number of live births	0.3	0.4	1.2	0.3	0.6	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	16.2	2.9	3.3	0.0	-4.0
Pulse rate	0.2	0.3	0.6	-0.2	0.5	0.8	0.3
Happiness	0.3	0.4	1.0	0.6	0.1	-1.0	0.4
Noisy workplace	0.8	1.0	3.3	0.2	-1.8	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.9	0.9	2.2	0.5	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.6	0.6	1.1	0.3	-1.6
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	0.2	-1.6	0.6	1.1
Asthma	0.4	0.8	1.9	0.3	-0.0	-1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.2	0.4	0.8	-0.9
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.2	-0.4	0.2	0.6
Depression (self-reported)	1.4	1.7	2.8	-1.0	-0.8	-1.5	1.7
Medication: Lansoprazole	0.9	1.0	3.4	-0.5	-1.8	-0.4	0.6
Prospective memory result	1.1	1.3	2.4	0.0	-1.5	-0.9	1.5
Lung cancer (father)	3.5	4.1	10.6	-0.4	-0.8	-3.2	2.2
Illnesses of mother	0.2	0.2	0.6	-0.1	0.8	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.4	20.4	2.8	3.5	0.9	-4.5
Pulse wave Arterial Stiffness index	1.7	1.9	3.2	-1.6	-1.1	-0.9	1.8
Impedance of arm (left)	1.8	8.4	16.0	2.1	4.0	1.8	-3.2
Arm fat mass (right)	1.0	4.3	9.5	-3.1	-1.3	1.4	2.0
Trunk predicted mass	0.1	0.5	0.8	0.7	0.5	-0.6	-0.9
Standing height	1.7	16.8	24.4	4.4	4.8	0.5	-4.9
Length of working week for main job	2.9	3.2	5.6	-1.9	-2.4	1.3	1.3
Exposure to tobacco smoke at home	0.4	0.5	1.8	0.0	-0.1	1.3	-0.3
Breastfed as a baby	0.2	0.3	0.5	0.6	0.7	-0.1	-0.4
Tense / ‘highly strung’	0.5	0.8	1.6	-1.1	-0.7	1.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.9	0.9	0.7	-2.0	0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.8	0.5	-0.7	-0.3
Birth weight of first child	3.0	5.4	7.9	-1.8	-2.8	-1.8	2.7
Peak expiratory flow (PEF)	2.8	6.4	10.3	2.8	3.2	-1.2	-2.5
Pulse wave reflection index	0.9	1.1	1.6	-0.9	-1.3	-1.0	1.0
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.9	1.7	0.5	-1.2	-1.1
Loud music exposure frequency	0.5	0.6	1.9	0.2	1.4	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.4	1.4	0.8	0.9	-1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.6	0.7	0.7	0.0	-1.9
Blood clot in the leg (DVT)	1.8	2.4	5.7	-0.2	-1.9	-0.3	2.4
Medication: Paracetamol	0.6	1.0	3.1	-0.4	-1.8	0.7	0.5
Headache pain in last month	0.6	1.1	1.9	-1.4	-1.3	0.9	0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2
Glaucoma (self-reported)	0.9	1.1	3.8	0.4	0.6	-0.1	-2.0
Gout (self-reported)	7.8	10.7	17.2	3.7	4.2	-1.0	-3.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.4	-0.7	-0.2	0.2
Medication: Amlodipine	1.0	1.4	3.6	1.0	0.5	0.8	-1.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.6	1.1	1.3	-1.0	-0.8
Birth weight	0.5	1.1	3.5	0.7	-0.1	-1.9	0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.6	1.2	0.5	-1.2	0.6
High blood pressure (siblings)	0.9	1.3	4.7	0.1	-0.7	-2.2	0.4
Forced vital capacity (FVC), Best measure	2.7	10.0	19.5	2.9	3.5	0.4	-4.4
Body fat percentage	1.0	4.1	7.2	-2.7	-1.5	1.2	2.3
Leg fat percentage (right)	2.5	9.1	13.5	-3.6	-3.1	0.6	3.7
Arm fat-free mass (right)	0.0	0.1	0.3	0.4	-0.3	-0.5	-0.3
Exposure to tobacco smoke outside home	2.9	3.8	9.0	-3.0	-1.7	0.6	1.7
Comparative body size at age 10	2.0	5.4	8.8	-2.3	-2.7	-0.5	3.0
Number of full brothers	0.1	0.2	0.4	0.0	-0.1	-0.7	0.5
Worry too long after embarrassment	0.6	1.0	2.6	0.1	1.1	0.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.4	-0.7	-0.6	-0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.2	-0.2	-0.9	0.8
Number of children fathered	2.4	2.7	4.5	1.7	1.6	0.8	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	6.0	0.5	2.4	-1.5	0.3
Age at first live birth	1.4	2.5	7.5	0.8	1.3	0.4	-2.7
Pulse wave peak to peak time	2.5	2.9	4.8	1.9	1.6	0.9	-2.2
Health satisfaction	2.0	2.6	6.9	-0.8	-1.2	-1.2	2.6
Shortness of breath walking on level ground	0.6	0.7	0.9	-0.8	-1.0	0.8	0.7
Qualifications: College or University degree	0.7	2.3	5.0	0.7	1.6	0.9	-2.2
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.5	1.1	-0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.1	0.3	-1.0	1.1	0.0
Emphysema/chronic bronchitis	2.6	2.9	7.0	-1.0	-1.1	-1.6	2.6
Medication for pain relief, constipation, heartburn	0.8	1.4	3.5	0.8	1.9	-0.4	-1.2
Neck or shoulder pain in last month	1.0	1.4	4.1	2.0	0.8	-0.1	-0.9
Medication: Blood pressure	0.1	0.1	0.3	-0.2	-0.6	-0.0	0.3
Angina (self-reported)	0.6	0.8	1.2	-1.1	-1.0	0.8	0.6
Migraine (self-reported)	1.3	1.6	3.1	-1.8	-1.3	0.4	1.2
Medication: Ibuprofen	0.0	0.1	0.1	-0.4	-0.1	0.3	-0.0
Medication: Allopurinol	5.9	7.9	11.5	3.4	3.2	-0.6	-3.1
Medication: Omeprazole	0.1	0.1	0.3	-0.3	0.6	-0.4	0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.5	-0.3	0.5	0.7
Mean time to correctly identify matches	1.2	2.3	3.9	-0.9	-2.0	-1.2	1.7
Heart disease (mother)	0.4	0.5	0.9	1.0	0.9	-0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.9	0.2	0.7	-2.2	0.2
Whole body fat mass	0.7	2.9	5.6	-2.4	-1.2	1.2	1.8
Leg fat mass (right)	1.4	5.3	8.6	-2.9	-2.3	0.5	2.6
Arm predicted mass (right)	0.0	0.1	0.3	0.3	-0.2	-0.6	-0.1
Pulse rate, automated reading	0.2	0.8	1.1	-1.0	0.6	1.1	0.8
Alcohol intake frequency.	0.1	0.2	0.5	0.7	-0.5	0.1	-0.1
Comparative height size at age 10	0.7	3.6	5.6	2.4	2.1	0.1	-2.1
Number of full sisters	2.1	2.5	8.5	-0.6	-0.5	2.9	-1.1
Suffer from ‘nerves’	0.2	0.3	0.6	-0.4	-0.3	0.4	-0.8
Overall health rating	1.1	2.4	4.9	-1.5	-1.5	-0.1	2.2
Chest pain or discomfort	2.6	3.7	6.2	2.0	2.5	-1.8	-1.1
Had major operations	0.9	1.1	1.7	-1.1	-0.2	-1.3	1.2
Age at last live birth	0.3	0.4	1.0	0.2	0.7	0.1	-1.0
Family relationship satisfaction	2.3	2.8	7.2	1.5	1.3	-2.7	-0.3
Leg pain on walking	0.6	0.7	1.9	-0.3	-1.4	1.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.7	-0.3	0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	0.6	-0.9	-0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.2	-0.7	0.3	-1.4	1.5
Medication: Aspirin	1.4	1.8	3.3	-0.7	-1.8	-0.5	1.7
Supplements: Vitamin C	1.5	1.7	4.0	2.0	-1.0	0.1	-1.4
Knee pain experienced in last month	1.4	2.2	4.2	-1.6	-1.4	-0.1	2.0
Hypertension (Self-reported)	0.3	0.7	1.2	-1.1	-1.0	-0.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	6.2	-2.5	-2.1	0.8	1.9
Illnesses of father: Heart disease	0.6	0.9	2.7	0.7	1.6	-0.4	-0.4
Illnesses of siblings: Diabetes	1.1	1.4	3.0	-0.5	-1.3	-0.7	1.7
Smoking status: Previous	0.8	1.1	2.0	1.4	1.2	0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.0	0.7	1.7	-0.5	-1.0
Whole body fat-free mass	0.0	0.2	0.4	0.3	0.4	-0.2	-0.6
Leg fat-free mass (right)	0.0	0.2	0.3	-0.2	0.5	0.6	-0.5
Arm fat percentage (left)	1.3	5.2	11.1	-3.3	-1.4	1.5	2.4
Average weekly red wine intake	0.9	1.4	2.3	1.2	0.4	-1.5	-1.3
Handedness (chirality/laterality): Left-handed	2.4	2.9	7.5	-1.9	-2.7	0.4	0.7
Mood swings	0.5	0.9	1.7	-0.4	-0.9	1.3	-0.9
Loneliness, isolation	0.6	0.9	2.5	0.2	-0.1	1.6	-1.0
Long-standing illness, disability or infirmity	0.5	0.7	1.7	0.2	1.1	1.3	-0.1
Ever had bowel cancer screening	2.2	2.6	5.9	-0.9	-1.8	-0.7	2.4
Diabetes diagnosed by doctor	0.4	0.6	1.1	-1.0	0.3	0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	7.9	1.8	0.1	-0.5	-2.8
Friendships satisfaction	4.5	5.5	10.0	2.8	1.8	-3.2	-1.0
Qualifications: nursing, teaching	0.2	0.3	1.2	-0.1	1.1	-0.2	-0.2
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.9	0.6	-0.2	0.6
Eye problems/disorders: Cataract	0.3	0.4	0.6	0.7	-0.8	0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.4	0.9	1.0	-0.3	-1.9
Medication for cholesterol	0.1	0.1	0.4	0.1	0.6	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	-0.1	-1.1	0.2	0.6
Back pain experienced in last month	0.1	0.2	0.4	-0.2	-0.1	0.6	-0.5
Mineral and other dietary supplements	1.1	1.4	4.9	0.1	0.6	2.2	-0.7
Breast cancer (self-reported)	0.3	0.3	0.8	0.6	0.1	-0.9	0.3
Asthma (self-reported)	0.4	0.8	2.0	0.5	0.2	-1.4	0.9
Osteoporosis (self-reported)	3.7	4.6	7.2	-2.4	-2.3	-0.3	2.7
Osteoarthritis (self-reported)	1.9	2.4	3.7	1.9	1.6	-0.4	-1.9
Medication: Aspirin	1.2	1.6	4.2	-0.5	-2.0	-0.2	1.4
Medication: Gliclazide	1.3	1.4	2.5	0.8	0.4	1.6	-1.6
Illnesses of father: None of the above (group 1)	1.2	1.5	3.1	1.3	1.0	-0.3	-1.8
Smoking status: Current	0.6	0.9	2.7	0.2	-1.6	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.5	-0.3	0.5	1.2	-0.6
Whole body water mass	0.0	0.2	0.5	0.3	0.5	-0.1	-0.7
Leg predicted mass (right)	0.0	0.2	0.2	-0.3	0.4	0.5	-0.5
Arm fat mass (left)	1.0	4.2	9.2	-3.0	-1.3	1.2	2.1
Number of self-reported non-cancer illnesses	2.0	3.4	6.3	-1.2	-2.2	-0.9	2.5
Average weekly champagne plus white wine intake	1.8	2.4	6.5	0.9	2.5	-1.2	-0.9
Miserableness	0.0	0.1	0.1	0.0	0.4	0.3	-0.2
Guilty feelings	3.4	5.0	12.5	1.4	2.2	0.9	-3.5
Wears glasses or contact lenses	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.1
Ever taken oral contraceptive pill	0.4	0.4	0.9	0.7	-0.2	-0.5	-1.0
Hearing aid user	0.3	0.4	1.0	-0.6	-1.0	0.1	0.2
Mother’s age at death	0.5	0.6	1.3	0.5	-0.4	1.0	-1.1
Financial situation satisfaction	0.7	0.9	2.0	1.4	0.6	-0.7	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	0.9	-0.0	-1.1	-0.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.4	0.2	1.1	-1.1
Eye problems/disorders: Glaucoma	0.6	0.8	2.9	0.1	0.3	0.2	-1.7
Medication: Blood pressure	0.1	0.2	0.6	-0.5	-0.1	0.8	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.1	0.0	1.1	-0.7
Supplements: Fish oil (including cod liver oil)	1.6	2.1	8.1	0.5	-0.2	-2.9	0.2
High cholesterol (Self-reported)	0.3	0.6	1.3	0.9	-0.3	-0.1	-1.1
Medication: Bendroflumethiazide	2.2	3.4	7.0	-1.6	-2.0	-0.4	2.6
Medication: Paracetamol	0.7	1.1	2.6	-0.8	-1.6	0.7	0.7
Medication: Lisinopril	1.6	2.0	4.6	1.5	1.1	0.1	-2.1
Medication: Atorvastatin	2.0	2.5	5.6	-2.4	-1.1	1.7	0.7
Illnesses of father: High blood pressure	0.1	0.2	0.3	-0.4	-0.1	0.6	-0.4
Alcohol drinker status: Never	0.2	0.2	0.4	0.2	-0.3	0.6	-0.6
Ever smoked	1.4	2.4	4.4	1.8	1.3	0.4	-2.1
Basal metabolic rate	0.0	0.1	0.1	-0.2	0.2	0.2	-0.3
Leg fat percentage (left)	2.3	8.2	11.9	-3.5	-2.9	0.8	3.4
Arm fat-free mass (left)	0.0	0.1	0.3	-0.2	-0.5	-0.2	0.1
Number of operations (self-reported)	0.3	0.5	1.6	0.2	-0.4	-1.3	0.3
Average weekly beer plus cider intake	0.2	0.3	0.7	0.4	-0.9	-0.2	0.2
Irritability	0.5	0.8	1.7	0.6	0.5	0.9	-1.3
Risk taking	0.1	0.2	0.5	0.3	0.3	-0.7	0.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	-1.0	-1.3	-0.9	0.7
Fractured/broken bones in last 5 years	1.8	2.3	3.7	1.6	1.9	-0.6	-1.7
Age started oral contraceptive pill	3.3	4.2	9.7	-2.1	-1.5	0.5	3.1
Diastolic blood pressure, automated reading	0.5	1.5	3.4	0.5	1.9	1.1	-1.1
Ever depressed for a whole week	0.2	0.3	0.8	-0.4	-0.9	-0.3	0.3
Unable to work because of sickness or disability	1.0	1.3	3.0	0.5	-0.2	1.3	-1.7
Commuting to job workplace: Cycle	1.4	1.7	3.6	1.9	0.9	0.5	-1.5
Myopia	0.3	0.4	0.9	-0.9	1.0	0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.7	1.3	1.3	0.3	-1.0
Cholesterol lowering medication	0.7	1.0	3.0	-0.6	-1.7	0.0	0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.2	0.4	-0.9	-0.1
Pain experienced in last month	0.0	0.1	0.1	0.3	0.3	0.1	-0.1
Supplements: Calcium	1.7	1.9	5.4	1.3	0.2	-2.3	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	0.4	0.5	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.8	-0.4	-0.0	0.1	0.9
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.4	-0.4	-2.1	-0.3	2.5
Heart disease (siblings)	0.5	0.7	1.2	0.6	1.1	-1.0	0.2
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.0	-0.6	0.6	-0.1
Pack years of smoking	2.4	3.5	7.4	-1.3	-2.7	0.1	2.2
Impedance of whole body	0.9	4.7	9.4	1.9	3.1	0.9	-2.2
Leg fat mass (left)	1.1	4.3	6.9	-2.6	-2.0	0.9	2.3
Arm predicted mass (left)	0.0	0.1	0.2	-0.1	-0.4	-0.5	0.2