TWAS hub - CDC42EP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0484	0.0179	3.7e-05	0.023	0.034	0.025	0.033	0.024	0.00046	3.2e-05	0.00032	4.2e-05	0.00039
2	YFS	Blood	0.0163	0.0083	1.5e-02	0.004	0.003	0.004	0.005	0.002	0.01300	2.6e-02	0.01600	5.0e-03	0.06200

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Allopurinol	6.8	9.0	15.0	-3.9	-1.7
Gout (self-reported)	6.7	9.2	17.1	-4.1	-1.2
Number of children fathered	6.4	7.2	9.7	-2.2	-3.1
Osteoporosis (self-reported)	5.5	6.8	7.7	2.8	2.4
Medication for pain relief, constipation, heartburn	5.4	9.3	9.9	3.1	3.0
Neck or shoulder pain in last month	5.4	7.6	12.8	-1.6	-3.6
Smoking status: Previous	5.2	7.7	9.4	-3.1	-2.5
Guilty feelings	5.2	7.9	13.0	-3.6	-1.6
Medication: Paracetamol	4.9	8.1	10.2	-3.2	-2.5
Age started oral contraceptive pill	4.8	6.0	6.2	2.5	2.4
Alcohol intake versus 10 years previously	4.7	7.1	8.1	-2.8	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.6	5.5	6.2	-2.2	-2.5
Eye problems/disorders: Cataract	4.5	5.2	6.1	-2.5	-2.1
Medication: Amlodipine	4.4	6.2	11.2	-3.3	-1.1
Chronic bronchitis/emphysema (mother)	4.1	4.8	8.3	-1.1	-2.9
Relative age voice broke	3.8	5.9	9.8	3.1	1.4
Eye problems/disorders: None of the above	3.8	4.4	7.1	2.7	1.3
Rheumatoid Arthritis	3.5	4.8	9.2	-3.0	-0.7
Blood Eosinophil Count	3.5	27.2	54.3	-7.4	-0.4
Past tobacco smoking	3.5	6.5	7.6	2.7	2.3
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.5	5.6	-2.4	-1.8
Reaction Time	3.4	6.5	11.8	3.4	1.1
Pulse rate	3.3	5.5	6.7	2.6	2.1
Mean time to correctly identify matches	3.1	5.8	10.5	3.2	1.1
Alcohol drinker status: Never	3.1	3.7	6.8	-0.8	-2.6
Fed-up feelings	3.0	5.5	5.6	-2.3	-2.4
Hip circumference	2.9	12.5	13.0	-3.5	-3.6
Back pain experienced in last month	2.9	4.3	5.0	-2.2	-1.9
Illness, injury, bereavement, stress in last 2 years	2.8	3.5	4.0	2.0	1.7
Leg fat-free mass (right)	2.8	14.9	15.3	-3.8	-3.9
Leg predicted mass (right)	2.8	14.7	15.4	-3.8	-3.9
Irritability	2.8	4.7	6.6	-2.6	-1.7
Pain experienced in last month	2.8	4.6	8.9	0.5	3.0
Maternal smoking around birth	2.6	3.8	4.6	-2.1	-1.7
Tense / ‘highly strung’	2.6	4.3	5.6	-2.4	-1.7
Verbal and Numeric Reasoning (VNR)	2.5	6.0	9.9	-1.4	-3.2
Alcohol intake frequency.	2.5	5.8	7.1	-2.1	-2.7
Illnesses of father: None of the above (group 1)	2.5	3.1	4.3	-1.4	-2.1
Medication: Paracetamol	2.5	3.9	4.1	-2.0	-1.9
Basal metabolic rate	2.5	13.9	14.3	-3.8	-3.7
Neuroticism score	2.4	5.0	6.2	-2.5	-1.9
Frequency of tiredness / lethargy in last 2 weeks	2.4	4.0	4.4	-1.9	-2.1
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	8.7	-2.9	-0.7
Medication: Ibuprofen	2.4	2.8	2.9	-1.7	-1.6
Number of full sisters	2.4	2.9	5.9	-2.4	0.1
Eye problems/disorders: Glaucoma	2.4	2.9	4.0	-2.0	1.3
High cholesterol (Self-reported)	2.4	4.2	5.9	-1.6	-2.4
Myopia	2.4	3.5	4.0	-1.7	-2.0
Blood Red Count	2.3	22.1	33.3	-3.3	-5.8
Smoking Status	2.3	5.6	6.4	-2.5	-2.2
Hypothyroidism (self reported)	2.3	5.3	9.4	-3.1	-1.1
Leg fat-free mass (left)	2.3	12.2	12.9	-3.4	-3.6
Leg predicted mass (left)	2.3	12.3	13.0	-3.4	-3.6
Pulse wave reflection index	2.3	2.9	4.6	-1.1	-2.1
Health satisfaction	2.3	3.0	5.7	2.4	0.5
Whole body water mass	2.3	12.9	13.8	-3.7	-3.5
Ever highly irritable/argumentative for 2 days	2.2	2.7	5.1	-0.5	-2.2
Had major operations	2.2	2.6	3.9	-1.2	-2.0
Whole body fat-free mass	2.2	12.7	14.0	-3.7	-3.4
Average weekly red wine intake	2.2	3.3	4.6	1.4	2.1
Arm fat-free mass (left)	2.2	11.1	11.5	-3.3	-3.4
Number of operations (self-reported)	2.2	3.3	5.2	-1.2	-2.3
Medication: Levothyroxine sodium	2.1	3.5	5.6	-2.4	-1.2
Trunk fat-free mass	2.1	11.8	14.6	-3.8	-3.0
Trunk predicted mass	2.1	11.7	14.6	-3.8	-3.0
Comparative body size at age 10	2.1	5.9	7.1	2.7	-2.2
Medication: Blood pressure	2.1	3.9	7.8	-2.8	-0.2
Ever smoked	2.1	3.8	5.3	-2.3	-1.5
Fractured/broken bones in last 5 years	2.1	2.7	5.1	0.5	2.2
Height	2.0	37.9	67.2	-8.2	-2.9
Neuroticism	2.0	4.9	6.3	-2.5	-1.9
Weight	2.0	10.1	11.5	-2.9	-3.4
Glaucoma (self-reported)	2.0	2.4	3.4	-1.8	1.2
Arm predicted mass (right)	2.0	10.4	10.6	-3.2	-3.2
Comparative height size at age 10	2.0	10.9	20.4	-4.5	-1.2
Neuroticism (Nagel 2018)	1.9	4.4	5.6	-2.4	-1.8
Taking other prescription medications	1.9	2.9	3.4	-1.9	-1.5
Worrier / anxious feelings	1.9	3.5	3.5	-1.9	-1.9
Pulse wave Arterial Stiffness index	1.9	2.2	3.9	-0.7	-2.0
Standing height	1.9	18.6	34.6	-5.9	-1.6
Bipolar Disorder or Schizophrenia	1.8	4.5	6.8	1.5	2.6
Mouth/teeth dental problems	1.8	2.8	5.1	0.7	2.3
Arm fat-free mass (right)	1.8	9.5	10.2	-3.2	-3.0
Hypertension (Self-reported)	1.8	4.9	9.5	-3.1	-0.5
Medication: Lisinopril	1.8	2.3	3.7	-1.9	0.9
Arm predicted mass (left)	1.8	9.2	9.6	-3.0	-3.1
Medication: Metformin	1.7	2.5	4.8	2.2	-0.3
Loud music exposure frequency	1.7	1.9	2.9	-1.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.2	-2.0	-0.5
Shortness of breath walking on level ground	1.7	2.0	2.4	1.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.2	-2.1	-1.7
Depressed Affect (Nagel 2018)	1.6	3.3	3.9	-2.0	-1.6
Cardiovascular Disease	1.6	5.2	8.7	-3.0	-1.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.0	-0.1	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.2	0.8	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.3	-1.8	-0.3
Medication: Gliclazide	1.6	1.8	1.9	1.3	1.4
Schizophrenia (2018)	1.5	3.1	3.2	1.7	1.8
LDL Cholesterol	1.5	2.3	4.2	2.1	-0.7
Hayfever, allergic rhinitis or eczema	1.5	3.3	5.4	-2.3	-1.1
Medication: Atenolol	1.5	1.8	2.5	-1.1	1.6
Trunk fat mass	1.5	6.5	8.7	-2.1	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	7.1	-2.7	-0.1
Illnesses of siblings	1.5	2.1	2.8	1.7	1.2
Emphysema/chronic bronchitis	1.5	1.7	3.1	1.7	0.5
Family relationship satisfaction	1.5	1.9	3.6	1.9	0.4
Cholesterol lowering medication	1.5	2.2	2.5	-1.4	-1.6
Schizophrenia vs Biploar Disorder	1.4	1.8	3.7	1.9	-0.1
Prostate Cancer	1.4	1.9	3.6	-0.5	-1.9
Relative age of first facial hair	1.4	2.9	5.6	2.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.2	-2.5	-0.3
Lung cancer (father)	1.4	1.6	3.1	-0.4	-1.8
Arm fat mass (right)	1.4	5.9	9.4	-1.5	-3.1
Forced vital capacity (FVC), Best measure	1.4	5.2	8.3	-2.9	-1.4
Medication: Aspirin	1.4	1.8	2.9	-1.7	-0.9
Number of self-reported non-cancer illnesses	1.4	2.4	4.5	-2.1	-0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.0	-1.7	-0.8
Diabetes (mother)	1.3	1.6	3.0	-0.6	-1.7
High blood pressure	1.3	3.6	6.9	-2.6	-0.5
Supplements: Glucosamine	1.3	1.7	2.4	-1.6	-0.9
Waist circumference	1.3	4.9	5.6	-2.0	-2.4
Forced vital capacity (FVC)	1.3	5.0	8.3	-2.9	-1.3
Noisy workplace	1.3	1.6	2.5	0.8	1.6
Birth weight of first child	1.3	2.4	4.3	0.7	-2.1
Pulse wave peak to peak time	1.3	1.6	3.0	0.3	1.7
Mineral and other dietary supplements	1.3	1.8	3.4	1.8	0.5
Arm fat mass (left)	1.3	5.3	8.6	-1.4	-2.9
Vascular/heart problems diagnosed by doctor	1.3	3.6	7.1	2.7	0.3
Basal cell carcinoma (self-reported)	1.3	1.5	2.9	-0.3	-1.7
Depression (Nagel 2018)	1.2	1.9	2.1	-1.5	-1.3
Schizophrenia (2014)	1.2	2.6	3.9	1.1	2.0
Waist Hip Ratio (WHR)	1.2	5.4	10.2	0.8	3.2
Medication: Co-codamol	1.2	1.4	2.5	-0.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	2.1	-1.2	-1.5
Had menopause	1.2	1.5	2.8	-0.5	1.7
Financial difficulties in last 2 years	1.2	1.6	2.1	-1.4	-1.0
Birth weight	1.2	2.6	5.3	2.3	-0.0
Qualifications: College or University degree	1.2	3.8	7.1	0.8	2.7
Pulse rate, automated reading	1.2	3.7	5.3	1.5	2.3
Bipolar Disorder (2018)	1.1	1.8	3.6	0.2	1.9
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.5	1.6	0.4
Heel T-Score	1.1	8.4	16.6	-4.1	0.3
BMI	1.1	6.1	12.2	-0.0	-3.5
Body mass index (BMI)	1.1	4.5	8.8	-0.5	-3.0
Number of incorrect matches in round	1.1	1.8	2.9	-1.7	-0.8
Whole body fat mass	1.1	4.7	7.0	-1.6	-2.6
Knee pain experienced in last month	1.1	1.6	3.0	-0.5	-1.7
Medication for cholesterol	1.1	1.6	3.3	1.8	0.0
Smoking status: Current	1.1	1.8	2.1	1.4	1.2
Coronary Artery Disease (CAD)	1.0	1.2	2.1	-0.5	1.5
Blood Platelet Count	1.0	11.7	23.3	-4.8	0.0
Number of treatments/medications taken	1.0	1.7	3.2	-1.8	-0.5
Impedance of leg (right)	1.0	4.7	9.0	0.6	3.0
Trunk fat percentage	1.0	4.0	6.0	-1.4	-2.4
Qualifications: CSEs or equivalent	1.0	1.3	1.5	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	5.1	-2.3	-1.2
Exposure to tobacco smoke outside home	1.0	1.4	1.6	-1.2	-1.1
Medication: Blood pressure	1.0	1.7	3.0	-1.7	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.3	1.1	1.1
Overall health rating	1.0	2.1	4.1	0.4	-2.0
Diastolic blood pressure, automated reading	1.0	2.9	5.9	-2.4	-0.2
Leg fat mass (left)	1.0	4.0	7.1	-0.9	-2.7
Worry (Nagel 2018)	0.9	1.8	2.0	-1.4	-1.3
Age at First Birth	0.9	1.3	2.5	0.1	1.6
Mean Putamen Volume	0.9	1.0	1.8	1.3	0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.2	1.8	0.5
Current tobacco smoking	0.9	1.4	1.6	1.3	1.1
Allergy	0.9	2.1	2.7	1.6	1.2
Length of working week for main job	0.9	1.0	1.8	-0.4	-1.3
Exposure to tobacco smoke at home	0.9	1.0	1.9	-0.3	-1.4
Heart disease (mother)	0.9	1.0	1.5	-0.8	1.2
Medication: Aspirin	0.9	1.2	1.3	-1.1	-1.0
Diabetes diagnosed by doctor	0.9	1.5	2.7	1.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.8	-1.3	-1.0
Average weekly champagne plus white wine intake	0.9	1.3	2.6	0.0	1.6
Wears glasses or contact lenses	0.9	1.1	1.9	1.4	0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.6	-1.3	-0.9
Intelligence (Savage-Jansen 2018)	0.8	2.6	5.1	-0.3	-2.3
Allergy or Eczema	0.8	2.0	4.0	-2.0	-0.0
Sitting height	0.8	5.4	7.4	-2.7	-1.8
Arm fat percentage (right)	0.8	3.2	6.0	-0.6	-2.5
Happiness	0.8	0.9	1.7	-1.3	-0.4
Depression (self-reported)	0.8	0.9	1.8	-1.4	-0.2
Prospective memory result	0.8	1.0	1.3	0.8	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.1	-2.0	-1.1
High blood pressure (siblings)	0.8	1.2	1.5	-1.2	-1.0
Asthma (self-reported)	0.8	1.7	2.9	-0.7	-1.7
Medication: Atorvastatin	0.8	1.0	1.3	-0.9	1.1
Pack years adult smoking proportion	0.7	1.1	2.0	0.3	-1.4
Hand grip strength (right)	0.7	1.9	2.8	-1.7	-1.0
Had other major operations	0.7	0.8	1.6	-1.3	0.2
Pain all over the body in last month	0.7	0.7	1.4	-0.3	-1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	-1.3	-0.4
Medication: Simvastatin	0.7	1.0	2.0	-0.3	-1.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	1.5	0.1
Asthma	0.7	1.4	2.7	-0.3	-1.6
Medication: Lansoprazole	0.7	0.7	1.5	1.2	-0.1
Leg fat mass (right)	0.7	2.9	5.5	-0.5	-2.4
Arm fat percentage (left)	0.7	2.7	5.2	-0.6	-2.3
Mood swings	0.7	1.3	2.0	-1.4	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	0.9	-0.8	-1.0
Alcohol drinker status: Previous	0.7	0.8	1.1	-0.7	-1.1
Pack years of smoking	0.7	1.0	1.9	0.3	-1.4
Impedance of whole body	0.7	3.8	7.5	0.3	2.7
Major Depression (MDD)	0.6	0.7	1.3	0.4	1.1
Systolic Blood Pressure	0.6	2.9	3.1	-1.6	1.8
Age when periods started (menarche)	0.6	1.4	2.5	0.5	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	0.7	-0.8	-0.8
Multivitamins +/- minerals	0.6	0.7	1.4	0.2	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	1.1	-0.3
Impedance of leg (left)	0.6	3.1	6.2	0.3	2.5
Diabetes (self-reported)	0.6	1.0	2.0	1.4	-0.1
Impedance of arm (left)	0.6	2.6	4.6	-0.7	2.1
Body fat percentage	0.6	2.6	4.8	-0.6	-2.2
Migraine (self-reported)	0.6	0.7	1.4	1.2	0.1
Illnesses of father: Heart disease	0.6	0.8	1.6	0.0	1.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	-1.0	-0.6
Long-standing illness, disability or infirmity	0.6	1.0	1.4	0.7	1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-0.3	-1.1
Ever depressed for a whole week	0.6	0.8	0.9	0.8	-1.0
Alzheimer’s Disease (in father)	0.5	0.6	0.8	-0.9	0.6
Neuroticism (2016)	0.5	0.8	1.5	-1.2	-0.0
Diabetes (father)	0.5	0.6	0.9	1.0	0.5
High blood pressure (mother)	0.5	0.8	1.4	-1.2	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	-0.1	-1.2
Hair/balding pattern: Pattern 4	0.5	1.3	2.5	0.4	1.6
Number of full brothers	0.5	0.6	1.1	0.3	1.1
Age at first live birth	0.5	0.9	1.0	-0.9	1.0
Illnesses of siblings: Diabetes	0.5	0.7	0.9	-0.6	-1.0
Loneliness, isolation	0.5	0.7	0.9	-0.6	-0.9
Ever taken oral contraceptive pill	0.5	0.6	0.7	-0.8	-0.7
Risk taking	0.5	0.7	0.8	0.8	0.9
Lung FVC	0.4	1.8	3.5	-1.9	-0.2
Vitamin and mineral supplements	0.4	0.5	0.9	0.1	-1.0
Townsend deprivation index at recruitment	0.4	0.5	1.0	-1.0	0.1
Average weekly fortified wine intake	0.4	0.5	0.8	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	-0.5	-0.9
Fluid intelligence score	0.4	0.8	1.4	-0.5	-1.2
Impedance of arm (right)	0.4	2.0	3.5	-0.7	1.9
Father’s age at death	0.4	0.6	0.7	-0.7	-0.9
Number of live births	0.4	0.6	0.7	-0.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	-1.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	-0.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.6	-0.5	-0.8
Suffer from ‘nerves’	0.4	0.7	0.9	-1.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.5	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	1.1	0.6
Miserableness	0.4	0.6	1.1	-0.4	-1.0
Mother’s age at death	0.4	0.5	0.9	0.9	0.4
Leg fat percentage (left)	0.4	1.4	2.5	0.5	-1.6
Crohns Disease (2017)	0.3	0.7	1.1	-0.4	-1.1
Lupus	0.3	0.4	0.5	0.6	0.7
Chronotype (morning person)	0.3	0.7	0.8	0.8	0.9
Average weekly spirits intake	0.3	0.3	0.7	0.8	0.0
Hearing difficulty/problems: Yes	0.3	0.4	0.6	-0.5	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.7	0.4
Angina	0.3	0.4	0.6	-0.8	0.5
Medication for hormone replacement therapy	0.3	0.4	0.5	0.5	0.7
Supplements: Zinc	0.3	0.4	0.7	0.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	-0.4	-0.8
Alcohol usually taken with meals	0.3	0.5	0.9	-0.2	1.0
Nervous feelings	0.3	0.6	1.0	-1.0	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	0.6	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.5	-0.8
Leg fat percentage (right)	0.3	1.1	1.3	0.9	-1.1
Angina (self-reported)	0.3	0.4	0.8	-0.9	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.3	0.7
Supplements: Vitamin C	0.3	0.3	0.5	-0.7	-0.3
Friendships satisfaction	0.3	0.4	0.7	0.4	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	-0.0
Commuting to job workplace: Cycle	0.3	0.3	0.3	0.5	-0.6
Ovarian Cancer	0.2	0.2	0.4	-0.1	0.6
Fasting Glucose	0.2	0.3	0.3	0.6	0.5
Triglycerides	0.2	0.3	0.6	-0.1	0.8
Ulcerative Colitis	0.2	0.3	0.4	-0.3	0.7
Tanning	0.2	2.8	2.9	1.7	1.6
Hand grip strength (left)	0.2	0.5	1.0	-1.0	0.1
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.8	0.0
Systolic blood pressure, automated reading	0.2	0.7	1.2	-0.5	1.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.4	-0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.7	-0.9	-0.2
Time employed in main current job	0.2	0.2	0.5	-0.1	0.7
Falls in the last year	0.2	0.3	0.5	-0.7	-0.1
Illnesses of mother	0.2	0.3	0.4	0.7	-0.3
Peak expiratory flow (PEF)	0.2	0.5	1.1	-1.0	0.0
Headache pain in last month	0.2	0.4	0.7	-0.8	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	0.8	0.4
Age at last live birth	0.2	0.3	0.5	-0.7	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.3	-0.7
Ever had bowel cancer screening	0.2	0.2	0.2	0.5	-0.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.7	-0.1
Heart disease (siblings)	0.2	0.2	0.3	-0.2	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.4	0.0
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.0	0.5
Breast Cancer	0.1	0.2	0.3	0.6	-0.1
HbA1C	0.1	0.1	0.1	0.3	0.4
HDL Cholesterol	0.1	0.1	0.2	0.5	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.4	-0.2
Blood White Count	0.1	0.5	1.0	-1.0	0.1
Respiratory disease	0.1	0.3	0.5	-0.3	-0.7
Lung FEV1/FVC ratio	0.1	0.4	0.8	0.9	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.5	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.2	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.4	0.3
Severe depression (siblings)	0.1	0.1	0.2	-0.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	0.0	-0.6
Serious illness, injury or assault to yourself	0.1	0.2	0.2	0.3	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	-0.4
Qualifications: None of the above	0.1	0.2	0.3	-0.2	-0.6
Medication: Ramipril	0.1	0.1	0.2	-0.0	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.6	0.2
Breastfed as a baby	0.1	0.1	0.2	0.1	0.4
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.6	0.3
Worry too long after embarrassment	0.1	0.2	0.4	-0.3	-0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.1	-0.4
Medication: Omeprazole	0.1	0.1	0.2	0.4	-0.4
Leg pain on walking	0.1	0.1	0.1	0.3	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.1	0.6
Breast cancer (self-reported)	0.1	0.1	0.1	-0.2	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.3	0.5	-0.2
Supplements: Calcium	0.1	0.1	0.2	0.5	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.5	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.2	-0.1
Crohns Disease (2012)	0.0	0.0	0.0	-0.2	-0.1
Hair Pigment	0.0	1.3	1.5	1.0	-1.2
Heart attack	0.0	0.0	0.0	-0.1	0.1
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.2	-0.1
Chest pain or discomfort	0.0	0.1	0.1	-0.3	0.2
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.2	-0.1
Hearing aid user	0.0	0.0	0.1	-0.3	0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.2	0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.1	-0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.1	-0.2

Hub : Genes

CDC42EP2

Models

Trait associations