Hub : Genes

CDYL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.163	0.0536	0.00220	-0.004	NA	0.031	NA	0.006	9.4e-01	NA	2.9e-03	NA	1.2e-01
2	GTEx	Pancreas	0.268	0.0930	0.00480	0.149	NA	0.131	NA	0.139	7.4e-07	NA	3.7e-06	NA	1.9e-06
3	TCGA	Breast Invasive Carcinoma	0.026	0.0107	0.00032	0.030	0.016	0.018	NA	0.022	7.4e-07	0.00026	1.2e-04	NA	1.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	1.8	5.3	-0.0	-0.5	2.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.1	-0.5	-0.9	1.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	-0.8	0.2	-1.4
Depression (Nagel 2018)	0.9	1.4	2.3	-1.5	-1.3	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.1	-0.9	-1.4	0.3
Neuroticism (Nagel 2018)	0.4	1.1	2.0	-0.9	0.5	-1.4
Schizophrenia (2018)	0.2	0.4	0.6	-0.5	-0.8	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.1	0.7	0.6	-1.1
Worry (Nagel 2018)	0.2	0.5	0.9	-0.0	1.0	-0.8
Alzheimer’s Disease (in mother)	2.9	3.4	5.1	-0.7	-2.2	-2.3
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.2	-0.4	-0.7
Alzheimer’s Disease (including proxy)	1.5	2.2	4.1	-0.5	-2.0	-1.5
Crohns Disease (2017)	2.8	6.1	9.4	-0.1	-3.1	-3.0
Irritable Bowel Disease (IBD)	2.8	6.7	13.5	-0.2	-2.5	-3.7
Ulcerative Colitis (UC)	1.6	3.0	7.8	-0.6	-0.8	-2.8
Major Depression (MDD)	3.5	4.2	5.3	-2.3	2.2	-1.6
Reaction Time	1.0	1.9	2.8	-1.6	-0.6	-1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.2	-0.7	0.9
Breast Cancer	17.1	41.3	116.7	2.7	-0.4	10.8
Ovarian Cancer	0.2	0.2	0.3	0.5	-0.5	0.4
Prostate Cancer	0.8	1.2	2.2	-1.5	1.2	0.0
Age at First Birth	0.3	0.4	0.6	0.5	-0.8	0.5
Bipolar Disorder (2011)	1.7	1.7	3.3	-0.2	-1.8	1.3
Body Mass Index (BMI) (2010)	0.9	1.2	3.0	-0.8	-1.7	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.6	-0.2	0.1
Crohns Disease (2012)	2.7	4.4	7.1	-0.1	-2.5	-2.7
Mean Putamen Volume	0.0	0.0	0.0	0.0	-0.0	-0.0
Fasting Glucose	0.5	0.6	1.8	0.1	-0.1	-1.4
HbA1C	0.3	0.3	0.6	0.0	0.8	-0.5
HDL Cholesterol	1.1	1.8	3.9	1.1	2.0	-0.2
LDL Cholesterol	0.4	0.7	1.0	-0.4	-1.0	1.0
Lupus	1.7	2.5	3.5	1.8	1.9	1.0
Neuroticism (2016)	0.1	0.1	0.4	-0.2	-0.6	0.2
Primary Biliary Cirrhosis	0.7	1.0	1.9	-0.4	1.0	-1.4
Rheumatoid Arthritis	0.8	1.0	2.3	-1.5	0.4	-0.8
Schizophrenia (2014)	0.0	0.0	0.0	-0.1	-0.2	0.1
Triglycerides	0.9	1.5	4.0	-0.5	-2.0	0.6
Type 2 Diabetes (T2D) (2012)	2.1	2.4	7.2	-0.0	2.7	0.0
Ulcerative Colitis	0.6	0.8	2.3	-0.4	-0.1	-1.5
Blood Eosinophil Count	0.9	7.3	12.7	-2.3	-2.0	-3.6
Blood Platelet Count	0.2	2.8	4.4	-1.7	-2.1	-1.1
Blood Red Count	0.5	4.4	11.4	3.4	-1.0	0.9
Blood White Count	0.1	0.9	1.8	-0.7	-1.3	-0.7
Heel T-Score	0.1	0.5	0.7	0.8	0.8	0.3
BMI	0.5	3.1	9.4	-0.1	-3.1	-0.1
Height	0.1	2.0	4.2	-0.4	-2.0	-1.3
Waist Hip Ratio (WHR)	0.6	2.7	3.4	-1.9	-1.4	-1.7
Systolic Blood Pressure	0.1	0.7	1.1	-0.9	-0.5	1.0
Smoking Status	0.0	0.1	0.2	0.1	-0.1	-0.5
Allergy or Eczema	0.3	0.7	1.3	-1.2	0.6	-0.6
Cardiovascular Disease	0.2	0.8	2.1	0.3	-1.5	0.4
Hypothyroidism (self reported)	2.8	6.4	17.1	-0.2	-4.1	-1.4
Respiratory disease	0.0	0.1	0.2	0.1	-0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-1.2	0.4	0.4
Lung FEV1/FVC ratio	0.1	0.4	0.5	0.5	0.6	-0.7
Lung FVC	0.1	0.5	1.4	0.3	-0.2	-1.2
Neuroticism	0.3	0.7	1.6	-0.8	0.0	-1.3
Chronotype (morning person)	0.3	0.6	1.1	-0.7	-1.0	0.6
Hair Pigment	0.0	0.9	2.3	1.5	-0.4	-0.4
Tanning	0.1	1.2	3.1	0.7	1.8	0.1
Hand grip strength (left)	0.5	1.3	2.3	1.5	1.2	-0.1
Number of treatments/medications taken	0.4	0.8	1.5	-0.9	0.2	-1.2
Average weekly spirits intake	1.0	1.2	3.3	1.8	0.2	-0.5
Sensitivity / hurt feelings	0.5	0.8	1.9	-1.4	-0.3	-0.7
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.5	-0.9	-1.2	1.2
Hearing difficulty/problems: Yes	0.8	1.2	1.7	1.3	-0.9	1.1
Relative age of first facial hair	0.4	0.8	2.2	1.5	-0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	0.9	-1.0	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	1.0	0.0	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.8	-0.0	0.0
Systolic blood pressure, automated reading	0.1	0.3	0.4	-0.6	0.4	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.3	0.5	-0.2
Angina	0.9	1.2	2.8	-0.6	-0.6	-1.7
Medication for hormone replacement therapy	0.5	0.6	1.2	-0.3	-0.6	1.1
Vitamin and mineral supplements	0.0	0.1	0.2	-0.4	0.1	-0.1
Supplements: Zinc	2.5	2.8	3.8	-2.0	-1.6	-1.4
Medication: Co-codamol	0.3	0.3	0.4	-0.6	0.6	0.5
Medication: Metformin	0.2	0.3	0.6	-0.4	0.1	-0.8
Diabetes (father)	0.4	0.5	1.2	0.2	1.1	0.5
Diabetes (mother)	0.7	0.8	1.5	0.7	1.2	0.7
Severe depression (siblings)	0.6	0.7	1.3	-1.1	0.1	0.9
Pack years adult smoking proportion	0.2	0.3	0.6	0.8	0.4	0.2
Impedance of leg (right)	0.1	0.7	0.8	0.9	0.9	-0.7
Leg fat-free mass (left)	0.4	2.1	4.6	-1.2	-2.1	-0.1
Trunk fat percentage	0.2	0.9	2.4	0.5	-1.6	-0.1
Hand grip strength (right)	0.3	0.9	2.3	1.5	0.7	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.3	0.0	0.7
Current tobacco smoking	0.1	0.2	0.7	0.1	-0.1	0.8
Average weekly fortified wine intake	2.3	2.6	7.3	2.7	0.7	-0.4
Maternal smoking around birth	0.1	0.1	0.2	-0.5	-0.3	0.4
Fed-up feelings	0.1	0.1	0.3	0.1	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.6	-0.6	-0.3	0.7
Relative age voice broke	0.5	0.8	2.4	1.5	0.2	0.1
Taking other prescription medications	0.1	0.1	0.2	0.3	0.3	-0.5
Age when periods started (menarche)	0.1	0.1	0.3	0.6	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.9	-0.4	0.9	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.7	-1.1	-0.9	-1.3
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.7	-0.4	-0.1	-1.6
Qualifications: CSEs or equivalent	1.3	1.7	3.9	-0.8	2.0	0.8
Serious illness, injury or assault to yourself	1.2	1.5	1.8	-1.0	-1.3	-1.2
High blood pressure	0.3	0.8	2.4	0.1	-1.6	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.2	0.5	-0.4
Multivitamins +/- minerals	0.2	0.2	0.5	0.7	-0.2	-0.3
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.2	-0.2	-0.9
Supplements: Glucosamine	0.6	0.7	1.0	-1.0	0.6	-0.9
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	2.8	-0.8	1.7	1.3
Medication: Atenolol	0.5	0.6	1.5	1.2	-0.3	0.3
Medication: Levothyroxine sodium	1.7	2.9	7.6	-0.6	-2.8	-0.9
Sitting height	0.2	1.4	3.2	-0.2	-1.8	0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.1	-1.0	-0.2
High blood pressure (mother)	0.5	0.7	1.1	-1.1	-1.0	0.1
Body mass index (BMI)	0.2	0.9	2.8	-0.0	-1.7	-0.1
Impedance of leg (left)	0.3	1.4	2.6	1.6	1.2	-0.6
Leg predicted mass (left)	0.4	2.0	4.5	-1.2	-2.1	-0.1
Trunk fat mass	0.4	1.6	4.9	-0.1	-2.2	-0.1
Waist circumference	0.8	2.8	6.9	-0.9	-2.6	-0.8
Number of incorrect matches in round	1.1	1.8	3.1	-1.8	0.4	-1.4
Past tobacco smoking	0.4	0.8	1.1	-0.4	1.0	1.1
Alcohol usually taken with meals	0.0	0.0	0.1	-0.3	0.0	0.3
Nervous feelings	0.4	0.7	1.4	0.1	1.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	-0.8	-0.3	-1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.8	0.5	-0.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-0.0	-0.4	1.3
Had menopause	0.8	1.0	1.3	-1.0	0.8	-1.2
Had other major operations	0.6	0.8	1.7	-0.7	0.4	-1.3
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.2	-0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.2	-0.3	-1.1	-1.1
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	7.5	-1.6	-2.7	-2.0
Qualifications: None of the above	0.1	0.2	0.5	-0.3	0.7	-0.0
Financial difficulties in last 2 years	1.0	1.4	3.0	-1.7	-1.0	-0.3
Mouth/teeth dental problems	1.0	1.5	2.5	1.6	1.4	0.4
Heart attack	0.1	0.2	0.4	-0.3	-0.2	-0.6
Allergy	0.1	0.2	0.5	0.2	0.2	0.7
Pain all over the body in last month	1.0	1.1	3.0	-1.7	-0.0	-0.4
Diabetes (self-reported)	0.4	0.5	1.3	-1.2	-0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	0.3	-1.1	0.8
Medication: Ramipril	0.3	0.4	0.9	-0.5	-0.2	-0.9
Medication: Simvastatin	3.1	4.5	6.8	-0.4	-2.6	-2.6
Fluid intelligence score	0.1	0.3	0.5	-0.7	-0.6	0.2
Illnesses of siblings	0.3	0.4	0.6	-0.8	0.2	0.8
Neuroticism score	0.1	0.1	0.2	-0.5	-0.1	-0.4
Weight	0.4	1.9	5.3	-0.6	-2.3	-0.2
Impedance of arm (right)	0.1	0.3	0.7	0.4	0.8	0.3
Arm fat percentage (right)	0.4	1.5	4.4	-0.1	-2.1	0.0
Trunk fat-free mass	0.4	2.3	5.0	-1.3	-2.2	0.4
Hip circumference	0.1	0.4	1.1	-0.3	-1.1	0.4
Time employed in main current job	0.1	0.1	0.1	-0.4	-0.1	0.3
Alcohol intake versus 10 years previously	1.1	1.6	3.5	0.0	1.2	1.9
Father’s age at death	0.1	0.2	0.3	0.4	-0.3	0.5
Worrier / anxious feelings	0.3	0.6	1.1	-1.1	0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	-0.1	0.4
Falls in the last year	0.4	0.6	1.6	-0.1	-0.2	1.3
Hair/balding pattern: Pattern 3	2.4	3.5	9.9	-0.5	-3.1	0.7
Number of live births	0.1	0.1	0.2	0.4	0.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	0.1	-0.1	-0.3
Pulse rate	0.4	0.7	1.3	-1.1	-0.3	0.9
Happiness	0.4	0.5	1.3	-1.1	0.4	-0.4
Noisy workplace	0.1	0.2	0.4	0.7	0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	1.0	0.0	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.3	-0.6	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.0	-0.1	0.9
Asthma	0.1	0.2	0.3	-0.1	0.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.2	0.9	0.8	-1.1
Medication: Cholesterol lowering	2.5	3.8	4.8	-2.2	-2.0	-1.6
Depression (self-reported)	0.5	0.6	1.2	-0.8	0.3	-1.1
Medication: Lansoprazole	0.2	0.2	0.5	-0.2	-0.4	-0.7
Prospective memory result	0.8	1.0	2.6	0.5	0.5	-1.6
Lung cancer (father)	0.9	1.1	2.2	1.5	0.6	0.8
Illnesses of mother	0.6	0.8	1.6	0.8	1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.4	0.7	0.1	0.2
Pulse wave Arterial Stiffness index	1.0	1.2	2.5	-1.6	-1.1	0.2
Impedance of arm (left)	0.2	0.9	2.6	-0.1	1.6	0.1
Arm fat mass (right)	0.4	1.5	4.5	0.1	-2.1	0.2
Trunk predicted mass	0.4	2.2	4.8	-1.2	-2.2	0.5
Standing height	0.1	1.0	2.2	-0.8	-1.5	0.2
Length of working week for main job	3.6	4.0	8.4	-1.0	-1.6	-2.9
Exposure to tobacco smoke at home	0.4	0.4	1.3	0.0	1.1	-0.2
Breastfed as a baby	3.0	3.7	11.0	0.5	-3.3	0.0
Tense / ‘highly strung’	0.1	0.2	0.4	0.4	0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	5.5	-1.3	-0.7	-2.3
Hair/balding pattern: Pattern 4	2.5	6.1	11.4	2.0	1.7	3.4
Birth weight of first child	0.3	0.6	1.4	-0.6	-1.2	0.0
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.6	-0.5	-0.5
Pulse wave reflection index	0.3	0.3	0.5	-0.7	-0.3	-0.6
Ever highly irritable/argumentative for 2 days	1.9	2.3	2.7	-1.5	-1.4	-1.6
Loud music exposure frequency	0.9	1.0	2.9	0.0	-1.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.6	0.4	-0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-1.2	0.4	-0.3
Blood clot in the leg (DVT)	0.7	0.9	1.8	1.3	-0.7	0.6
Medication: Paracetamol	1.2	1.9	5.7	0.2	2.4	0.2
Headache pain in last month	0.8	1.3	3.0	0.4	1.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.5	1.5	1.9	0.3
Glaucoma (self-reported)	2.2	2.6	4.8	1.7	2.2	-0.1
Gout (self-reported)	0.6	0.8	1.6	0.2	-0.8	-1.3
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	13.1	-0.2	-3.6	-1.2
Medication: Amlodipine	1.8	2.5	4.0	-1.7	-2.0	0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.1	-1.5	-1.0	-0.6
Birth weight	2.6	5.7	9.8	-2.7	-3.1	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.9	-0.8	-0.1
High blood pressure (siblings)	0.1	0.2	0.5	-0.0	0.7	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.7	0.5	0.3
Body fat percentage	0.4	1.4	4.2	0.1	-2.0	-0.4
Leg fat percentage (right)	0.5	1.9	4.8	-0.4	-2.2	-0.9
Arm fat-free mass (right)	0.2	1.3	3.2	-0.7	-1.8	0.1
Exposure to tobacco smoke outside home	2.7	3.6	7.9	0.1	1.7	2.8
Comparative body size at age 10	0.7	1.9	3.3	-1.4	-1.8	-0.5
Number of full brothers	1.4	1.8	3.5	1.9	-1.3	0.4
Worry too long after embarrassment	0.8	1.4	3.7	-1.9	0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.1	-1.8	-0.5	0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.1	-0.2	-0.4
Number of children fathered	0.5	0.6	1.3	1.1	-0.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	4.7	-1.7	-2.2	-0.7
Age at first live birth	0.6	1.0	1.9	-1.4	1.0	0.4
Pulse wave peak to peak time	1.0	1.2	2.5	1.6	1.0	-0.0
Health satisfaction	0.3	0.4	0.8	-0.5	0.3	0.9
Shortness of breath walking on level ground	3.1	3.7	4.8	-1.7	-2.2	-1.8
Qualifications: College or University degree	0.4	1.1	2.3	-1.5	-1.0	-0.4
Eye problems/disorders: None of the above	1.7	1.9	5.2	-0.6	-2.3	-0.5
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.1	-1.6	0.1	-1.8
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.1	-0.9	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.3	2.0	-0.2	-1.4	1.3
Neck or shoulder pain in last month	0.9	1.3	2.8	-1.0	1.7	0.0
Medication: Blood pressure	0.4	0.8	2.1	-0.2	-1.4	0.4
Angina (self-reported)	1.1	1.4	3.3	-0.7	-0.7	-1.8
Migraine (self-reported)	1.4	1.7	4.2	1.0	2.0	0.2
Medication: Ibuprofen	1.0	1.2	2.9	0.6	0.5	-1.7
Medication: Allopurinol	0.2	0.3	0.6	0.4	-0.4	-0.8
Medication: Omeprazole	0.8	0.9	2.0	1.4	0.7	-0.5
Medication: Seretide 50 evohaler	1.8	2.1	2.8	-1.5	-1.0	-1.7
Mean time to correctly identify matches	1.1	2.2	4.0	-2.0	-1.2	-1.0
Heart disease (mother)	1.3	1.6	3.5	0.3	-1.9	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	-0.9	1.1	0.7
Whole body fat mass	0.5	2.2	6.6	-0.3	-2.6	-0.1
Leg fat mass (right)	0.7	2.5	6.6	-0.7	-2.6	-0.7
Arm predicted mass (right)	0.2	1.0	2.5	-0.7	-1.6	0.1
Pulse rate, automated reading	0.1	0.2	0.4	-0.2	-0.6	0.5
Alcohol intake frequency.	0.8	2.0	5.3	-0.6	2.3	0.4
Comparative height size at age 10	0.1	0.4	0.8	0.6	-0.4	0.9
Number of full sisters	0.3	0.4	0.5	0.5	0.5	0.7
Suffer from ‘nerves’	0.2	0.3	0.5	0.7	0.3	0.5
Overall health rating	0.5	1.1	2.3	-0.6	1.5	0.8
Chest pain or discomfort	0.6	0.9	2.2	0.4	-0.6	-1.5
Had major operations	1.6	1.9	3.6	1.5	1.9	-0.1
Age at last live birth	0.6	0.8	2.3	-1.5	0.4	0.2
Family relationship satisfaction	1.0	1.2	2.3	-1.5	-0.3	-1.1
Leg pain on walking	1.0	1.3	2.0	-0.5	-1.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.3	0.5	1.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	-0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.6	1.3	1.0	-0.0
Medication: Aspirin	0.2	0.2	0.4	0.6	-0.6	0.1
Supplements: Vitamin C	0.1	0.1	0.2	-0.0	0.5	-0.2
Knee pain experienced in last month	0.3	0.5	0.7	0.8	0.8	0.4
Hypertension (Self-reported)	0.2	0.6	1.6	0.5	-1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.7	0.7	-0.9	0.9
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	-0.0	0.3
Illnesses of siblings: Diabetes	0.7	0.9	1.3	-0.4	-1.1	-1.1
Smoking status: Previous	0.5	0.8	1.2	-0.1	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.0	0.4	0.3
Whole body fat-free mass	0.4	2.2	5.3	-1.1	-2.3	0.1
Leg fat-free mass (right)	0.3	1.5	3.6	-0.8	-1.9	0.3
Arm fat percentage (left)	0.3	1.1	3.2	-0.2	-1.8	-0.2
Average weekly red wine intake	0.3	0.4	0.9	0.5	-0.9	0.4
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.2	-1.9	-2.3	0.2
Mood swings	0.6	1.0	1.3	-0.9	-1.0	-1.1
Loneliness, isolation	0.2	0.3	0.8	0.3	0.9	0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-1.1	0.3	0.2
Ever had bowel cancer screening	0.3	0.4	0.7	-0.0	0.6	-0.9
Diabetes diagnosed by doctor	0.3	0.5	1.1	-1.1	0.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.4	-0.6	-1.0
Friendships satisfaction	2.1	2.6	4.0	-2.0	0.6	-1.8
Qualifications: nursing, teaching	0.4	0.6	1.2	0.4	1.1	0.7
Commuting to job workplace: Walk	1.7	1.8	2.5	-0.9	1.4	1.6
Eye problems/disorders: Cataract	0.5	0.6	1.0	-0.1	0.9	1.0
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	2.8	-0.4	-1.4	-1.7
Medication for cholesterol	0.5	0.8	1.1	-0.6	1.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.4	-0.7	0.1	-1.8
Back pain experienced in last month	0.3	0.5	1.3	-0.1	1.1	0.3
Mineral and other dietary supplements	0.5	0.7	1.5	1.2	0.4	0.7
Breast cancer (self-reported)	7.4	8.8	22.4	-2.0	-0.1	-4.7
Asthma (self-reported)	0.1	0.2	0.3	-0.0	0.5	-0.4
Osteoporosis (self-reported)	0.2	0.3	0.5	0.5	0.1	0.7
Osteoarthritis (self-reported)	0.5	0.7	0.9	-0.8	0.7	-0.9
Medication: Aspirin	0.0	0.1	0.1	0.2	-0.3	0.2
Medication: Gliclazide	1.3	1.5	4.2	-0.5	-2.0	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-0.2	0.7	-1.0
Smoking status: Current	0.1	0.1	0.3	0.0	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.9	2.0	0.7	-0.3
Whole body water mass	0.4	2.2	5.6	-1.0	-2.4	0.2
Leg predicted mass (right)	0.3	1.6	4.1	-0.8	-2.0	0.2
Arm fat mass (left)	0.3	1.1	3.4	-0.0	-1.8	0.1
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	-0.6	-0.2	-0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.7	-0.0	0.7
Miserableness	0.4	0.8	1.4	-0.0	1.0	-1.2
Guilty feelings	0.2	0.2	0.4	-0.2	-0.6	-0.5
Wears glasses or contact lenses	0.1	0.2	0.4	-0.1	0.3	0.6
Ever taken oral contraceptive pill	0.8	0.9	2.3	-0.2	-1.5	0.4
Hearing aid user	0.9	1.0	1.5	0.3	1.2	1.2
Mother’s age at death	0.4	0.5	1.0	0.7	1.0	-0.2
Financial situation satisfaction	0.2	0.3	0.4	-0.6	-0.4	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.2	0.9	-0.6
Commuting to job workplace: Public transport	0.6	0.7	1.9	-1.4	-0.1	0.5
Eye problems/disorders: Glaucoma	3.0	3.6	9.6	1.1	3.1	-0.3
Medication: Blood pressure	0.3	0.6	0.8	0.9	-0.9	0.0
Pain type(s) experienced in last month: Hip pain	1.6	2.1	5.0	-2.2	-0.3	-1.0
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.0	-2.2	0.1	-1.1
High cholesterol (Self-reported)	0.4	0.8	2.0	-0.5	0.3	-1.4
Medication: Bendroflumethiazide	0.5	0.7	1.4	-1.2	-0.5	0.7
Medication: Paracetamol	0.9	1.4	3.5	-0.8	1.9	-0.3
Medication: Lisinopril	1.0	1.3	2.7	0.7	-0.8	-1.6
Medication: Atorvastatin	0.4	0.4	0.7	-0.7	0.4	0.8
Illnesses of father: High blood pressure	0.7	0.9	1.8	-0.3	-1.4	0.8
Alcohol drinker status: Never	1.8	2.1	5.6	-0.8	-0.2	-2.4
Ever smoked	0.2	0.3	0.6	0.8	-0.4	-0.3
Basal metabolic rate	0.3	1.8	4.8	-0.8	-2.2	0.2
Leg fat percentage (left)	0.4	1.5	4.0	0.0	-2.0	-0.8
Arm fat-free mass (left)	0.2	1.2	3.4	-0.6	-1.9	-0.1
Number of operations (self-reported)	0.5	0.7	2.2	0.1	0.2	-1.5
Average weekly beer plus cider intake	0.2	0.3	0.8	0.4	-0.1	-0.9
Irritability	1.2	2.0	5.1	-0.4	-0.9	-2.2
Risk taking	0.4	0.6	1.7	-1.3	-0.0	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	-0.2	-1.6	0.1
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-1.0	1.3	-0.2
Age started oral contraceptive pill	0.8	1.0	1.5	1.2	-0.8	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	0.7	0.1	-0.8	0.7
Ever depressed for a whole week	2.8	3.5	8.6	0.2	-2.9	-1.4
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.6	-0.6	-0.4
Commuting to job workplace: Cycle	1.3	1.6	2.3	-1.5	-1.5	-0.6
Myopia	0.1	0.2	0.4	-0.2	0.2	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.7	-0.2	1.3	0.1
Cholesterol lowering medication	0.5	0.7	1.1	0.6	-0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	1.0	0.2	-0.3
Pain experienced in last month	1.6	2.6	7.8	-0.2	-2.8	0.1
Supplements: Calcium	1.4	1.5	3.6	-0.8	-0.5	-1.9
Basal cell carcinoma (self-reported)	0.2	0.2	0.2	0.5	0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.9	-0.2	-0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	1.3	-0.9	0.5
Heart disease (siblings)	1.8	2.2	6.1	0.7	0.4	-2.5
Alcohol drinker status: Previous	0.0	0.0	0.0	0.2	0.2	0.0
Pack years of smoking	0.2	0.3	0.6	0.8	0.5	0.4
Impedance of whole body	0.2	1.2	2.7	0.9	1.6	-0.2
Leg fat mass (left)	0.6	2.2	6.1	-0.5	-2.5	-0.6
Arm predicted mass (left)	0.3	1.3	3.6	-0.6	-1.9	0.1