Hub : Genes

CEL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.4470	0.1120	0.00170	-0.008	NA	-0.008	NA	-0.008	7.3e-01	NA	7.4e-01	NA	7.2e-01
2	YFS	Blood	0.0318	0.0115	0.00035	0.019	0.009	0.022	0.013	0.022	6.1e-07	0.00058	8.7e-08	3.8e-05	7.4e-08
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0494	0.0228	0.00074	0.006	0.007	-0.002	NA	-0.002	6.6e-02	0.05400	7.1e-01	NA	7.1e-01
4	TCGA	Lung Squamous Cell Carcinoma	0.0293	0.0135	0.00037	0.016	0.023	0.025	NA	0.028	6.1e-03	0.00100	7.1e-04	NA	3.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.7	1.6	-1.3	0.3	1.0	0.3
Bipolar Disorder or Schizophrenia	0.4	0.9	2.1	-1.4	-0.6	0.1	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-1.4	-0.3	-0.3	0.4
Depression (Nagel 2018)	0.8	1.2	2.4	-0.7	-0.7	1.5	1.2
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.6	0.3	-2.1	1.5	1.9
Neuroticism (Nagel 2018)	0.5	1.3	2.5	-1.5	-0.1	-0.2	1.6
Schizophrenia (2018)	0.9	1.8	4.2	-2.1	-1.0	-0.8	1.2
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	0.2	-0.5	-0.9	-0.5
Worry (Nagel 2018)	0.8	1.7	5.1	-1.2	-0.6	0.0	2.3
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.3	0.5	-0.4	0.9
Alzheimer’s Disease (in father)	2.0	2.2	4.5	-2.1	-0.9	1.6	0.9
Alzheimer’s Disease (including proxy)	1.2	1.7	3.8	-1.6	2.0	-0.6	-0.2
Crohns Disease (2017)	0.0	0.1	0.2	0.2	-0.1	-0.4	0.5
Irritable Bowel Disease (IBD)	0.5	1.3	4.8	-0.2	-0.5	-0.1	2.2
Ulcerative Colitis (UC)	0.7	1.4	5.2	-0.5	-0.2	0.2	2.3
Major Depression (MDD)	0.9	1.1	3.5	0.2	-0.2	1.0	1.9
Reaction Time	0.9	1.7	4.3	1.5	-0.2	2.1	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.3	-0.6	-1.2	0.4	2.1
Breast Cancer	0.5	1.2	3.2	0.1	1.8	-1.2	-0.2
Ovarian Cancer	0.3	0.5	1.1	1.0	0.2	0.7	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	1.0	0.6	0.6	-1.0	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.6	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.0	-1.4	-0.4	0.0	1.2
Coronary Artery Disease (CAD)	0.3	0.4	1.4	-0.4	0.0	-1.2	0.3
Crohns Disease (2012)	0.4	0.7	2.0	0.7	-0.4	0.2	1.4
Mean Putamen Volume	0.3	0.3	1.1	-1.1	-0.3	-0.0	0.0
Fasting Glucose	1.0	1.2	2.0	0.4	-1.4	1.0	1.2
HbA1C	0.3	0.3	0.7	-0.8	-0.4	0.6	0.1
HDL Cholesterol	1.0	1.6	3.2	1.3	1.8	-0.9	-0.8
LDL Cholesterol	0.3	0.4	1.0	-0.6	-0.5	0.4	-1.0
Lupus	0.1	0.2	0.3	0.5	-0.3	0.6	-0.2
Neuroticism (2016)	0.5	0.8	2.9	-1.7	0.0	-0.4	0.3
Primary Biliary Cirrhosis	1.6	2.3	4.5	-2.1	-1.5	-0.3	-1.5
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	-0.4	-0.1	-0.6
Schizophrenia (2014)	1.4	3.0	7.5	-2.7	-1.1	0.2	1.8
Triglycerides	1.0	1.6	2.4	-1.0	-1.5	1.2	1.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.7	-1.9	-0.9	0.4	1.2
Ulcerative Colitis	0.2	0.4	0.6	-0.7	-0.6	-0.1	0.8
Blood Eosinophil Count	0.4	3.3	6.7	-0.6	2.3	2.6	0.8
Blood Platelet Count	2.1	24.3	44.2	-1.3	-5.3	6.7	4.8
Blood Red Count	1.6	15.3	34.2	5.8	4.3	-1.9	2.3
Blood White Count	0.2	1.4	2.3	-1.0	0.8	1.5	1.4
Heel T-Score	0.2	1.4	3.4	1.4	-0.4	0.4	1.9
BMI	0.1	0.5	1.0	0.3	0.7	0.6	1.0
Height	0.2	3.2	7.3	1.0	-2.7	2.0	0.4
Waist Hip Ratio (WHR)	0.3	1.2	1.9	-1.1	-0.7	1.1	-1.4
Systolic Blood Pressure	0.5	2.6	6.2	0.4	-2.5	2.0	-0.1
Smoking Status	3.5	8.4	12.7	-3.6	2.0	-2.6	-3.2
Allergy or Eczema	0.6	1.6	2.6	-1.3	0.2	1.5	1.6
Cardiovascular Disease	0.2	0.7	1.3	-1.1	0.3	-0.9	-0.9
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.3	0.4	-0.5	0.8
Respiratory disease	0.5	1.1	1.7	-1.1	1.3	-0.9	0.9
Type 2 Diabetes (T2D) (2018)	2.2	4.2	8.5	0.8	-2.9	2.4	1.4
Lung FEV1/FVC ratio	0.1	0.4	1.0	0.7	-0.4	0.4	1.0
Lung FVC	0.3	1.6	2.8	1.5	1.0	-0.5	-1.7
Neuroticism	0.8	2.0	5.2	-1.3	-1.1	0.2	2.3
Chronotype (morning person)	0.3	0.6	1.4	0.7	0.4	-1.2	0.6
Hair Pigment	0.1	1.4	4.6	-2.1	0.3	0.6	0.8
Tanning	0.0	0.3	0.6	-0.8	0.5	-0.2	0.5
Hand grip strength (left)	0.7	1.8	2.6	1.0	1.6	-1.5	-1.2
Number of treatments/medications taken	0.3	0.5	0.9	-0.6	-0.6	-0.5	0.9
Average weekly spirits intake	0.1	0.1	0.2	-0.1	0.3	0.1	-0.5
Sensitivity / hurt feelings	0.3	0.5	1.8	-0.3	0.4	-0.1	1.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.8	-1.4	0.1	1.7	1.2
Hearing difficulty/problems: Yes	0.7	1.1	3.4	0.9	0.4	-1.9	-0.5
Relative age of first facial hair	0.4	0.8	1.7	-1.3	0.1	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	0.4	0.9	-1.5	-0.0
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.7	0.8	-0.6	-1.4	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	-0.4	0.2	-0.2	1.6
Systolic blood pressure, automated reading	1.0	3.0	7.4	-0.2	-2.7	1.9	1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.8	1.3	0.3	0.1	0.0
Angina	0.5	0.7	1.8	1.3	0.8	-0.4	0.0
Medication for hormone replacement therapy	0.5	0.6	1.5	-1.2	-0.6	-0.7	0.2
Vitamin and mineral supplements	0.1	0.1	0.4	-0.1	0.1	-0.7	-0.3
Supplements: Zinc	0.9	1.0	2.7	0.4	1.0	-0.5	-1.6
Medication: Co-codamol	0.2	0.2	0.4	-0.6	-0.4	0.3	-0.6
Medication: Metformin	0.9	1.3	3.1	0.5	-1.3	1.8	0.6
Diabetes (father)	0.3	0.3	0.9	1.0	0.1	-0.5	-0.3
Diabetes (mother)	0.3	0.4	1.0	-0.2	-0.6	1.0	-0.4
Severe depression (siblings)	0.2	0.2	0.3	-0.6	-0.2	0.4	0.5
Pack years adult smoking proportion	0.7	1.1	2.4	-1.6	-1.1	0.4	-0.7
Impedance of leg (right)	0.1	0.6	1.8	1.3	-0.7	0.2	0.1
Leg fat-free mass (left)	0.0	0.1	0.2	-0.4	0.0	0.4	0.1
Trunk fat percentage	0.1	0.3	0.8	0.4	0.1	0.6	0.9
Hand grip strength (right)	0.5	1.4	2.7	0.2	1.2	-1.7	-1.1
Townsend deprivation index at recruitment	0.4	0.6	1.7	-1.3	0.4	0.3	-0.6
Current tobacco smoking	3.4	5.6	15.7	-4.0	1.0	-1.2	-2.0
Average weekly fortified wine intake	0.9	1.0	3.1	1.8	0.4	-0.8	0.4
Maternal smoking around birth	0.2	0.3	0.5	-0.6	-0.6	-0.7	-0.1
Fed-up feelings	0.4	0.8	2.2	-1.5	0.5	0.8	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	3.5	-1.9	-0.4	1.8	0.3
Relative age voice broke	0.7	1.0	2.9	-0.8	-0.7	1.7	-0.3
Taking other prescription medications	0.4	0.6	2.0	-0.6	-0.2	-0.0	1.4
Age when periods started (menarche)	0.2	0.5	1.0	-0.8	-1.0	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.4	0.9	-1.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	0.2	0.6	-0.9	0.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.2	-2.0	0.0	0.5	1.1
Qualifications: CSEs or equivalent	1.0	1.3	3.9	1.0	0.7	-0.3	-2.0
Serious illness, injury or assault to yourself	0.2	0.3	1.0	-0.1	0.1	-1.0	-0.1
High blood pressure	0.3	0.9	2.0	-1.0	0.1	-1.4	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	0.4	0.7	0.7
Multivitamins +/- minerals	0.8	1.1	2.0	1.2	-0.7	1.4	0.5
Stomach or abdominal pain in last month	1.5	1.9	2.9	-1.3	-1.7	1.1	1.3
Supplements: Glucosamine	2.3	3.0	10.1	1.2	-0.8	0.1	3.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.2	0.2	-0.6	-1.8	0.6
Medication: Atenolol	2.5	3.2	8.1	2.9	0.8	-0.9	-1.8
Medication: Levothyroxine sodium	0.5	0.9	2.4	-0.9	-1.5	0.4	0.6
Sitting height	0.6	4.2	9.7	0.5	-1.8	2.0	3.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	0.3	-0.5	0.8	1.2
High blood pressure (mother)	0.4	0.5	1.1	-0.6	-0.2	1.0	0.7
Body mass index (BMI)	0.0	0.2	0.4	-0.1	0.2	0.3	0.6
Impedance of leg (left)	0.0	0.2	0.5	0.7	-0.3	0.2	0.5
Leg predicted mass (left)	0.0	0.1	0.2	-0.4	-0.0	0.4	0.1
Trunk fat mass	0.1	0.3	0.6	0.4	0.2	0.6	0.8
Waist circumference	0.1	0.3	1.0	-0.2	-0.5	1.0	0.3
Number of incorrect matches in round	0.1	0.1	0.2	-0.1	0.4	0.1	-0.4
Past tobacco smoking	1.6	3.0	4.5	2.0	-0.9	1.6	2.1
Alcohol usually taken with meals	0.0	0.1	0.2	-0.1	-0.3	-0.0	0.4
Nervous feelings	1.0	1.9	3.1	-1.3	-1.5	0.7	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.6	-1.6	0.7	0.3	1.2
Hearing difficulty/problems with background noise	0.3	0.5	1.1	-1.0	-0.5	-0.2	0.8
Hair/balding pattern: Pattern 2	1.2	1.5	2.7	1.6	0.4	-1.1	-1.4
Had menopause	0.3	0.3	1.0	0.1	-0.3	0.4	1.0
Had other major operations	0.7	0.9	1.8	0.9	1.3	-0.7	-0.6
Forced vital capacity (FVC)	0.2	0.6	1.1	0.9	0.6	0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.3	0.7	-0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-1.0	0.7	-0.6	-0.2
Qualifications: None of the above	0.4	0.9	1.9	-1.4	-0.1	1.0	-0.8
Financial difficulties in last 2 years	1.2	1.6	2.1	-1.4	1.5	-0.4	-1.4
Mouth/teeth dental problems	0.3	0.5	1.0	0.2	-0.5	0.8	1.0
Heart attack	2.5	3.2	3.9	2.0	2.0	-1.2	-1.9
Allergy	0.6	1.3	2.5	1.6	0.4	-1.3	-0.9
Pain all over the body in last month	0.8	0.9	2.1	-0.5	1.0	0.5	-1.4
Diabetes (self-reported)	1.3	2.1	3.7	0.5	-1.9	1.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	-1.0	0.3	-0.1	-1.1
Medication: Ramipril	0.2	0.3	0.6	0.1	0.8	-0.6	0.2
Medication: Simvastatin	2.1	3.1	6.8	2.6	-1.8	-0.6	1.4
Fluid intelligence score	0.8	1.8	3.9	0.5	-2.0	0.5	1.6
Illnesses of siblings	5.0	7.0	11.6	3.1	1.8	-1.9	-3.4
Neuroticism score	0.9	1.9	4.1	-2.0	-1.0	0.5	1.4
Weight	0.1	0.3	0.6	-0.4	-0.2	0.8	0.8
Impedance of arm (right)	0.2	1.1	2.5	0.3	-1.2	0.8	1.6
Arm fat percentage (right)	0.1	0.3	1.1	0.0	-0.1	0.4	1.0
Trunk fat-free mass	0.0	0.2	0.3	-0.4	-0.5	0.6	-0.2
Hip circumference	0.1	0.3	0.7	-0.2	-0.1	0.8	0.7
Time employed in main current job	0.3	0.3	0.4	-0.6	-0.4	0.7	0.6
Alcohol intake versus 10 years previously	0.9	1.3	2.7	0.7	1.4	0.3	-1.6
Father’s age at death	0.4	0.5	1.6	-0.3	0.6	1.2	0.3
Worrier / anxious feelings	1.4	2.7	6.1	-1.4	-0.9	1.4	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.0	-0.1	-1.6	2.0	0.9
Falls in the last year	0.3	0.4	0.9	0.3	0.9	-0.4	-0.7
Hair/balding pattern: Pattern 3	0.6	1.0	2.4	-0.7	-0.4	-0.8	1.6
Number of live births	2.0	2.8	4.6	0.4	2.1	-2.1	-1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.7	1.3	0.5	0.3	-0.3
Pulse rate	0.3	0.5	1.2	0.1	1.1	0.4	-0.8
Happiness	1.7	2.1	4.6	-2.1	-0.1	1.4	1.4
Noisy workplace	2.3	2.8	7.3	-0.7	2.7	-1.5	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	0.1	0.9	-0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.3	-0.7	0.2	0.8
Mouth/teeth dental problems: Dentures	0.3	0.6	1.2	-0.2	-1.1	-0.1	1.0
Asthma	0.9	1.7	4.5	-2.1	1.3	-0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.9	-0.9	0.5	-0.0
Medication: Cholesterol lowering	0.4	0.6	1.6	0.8	-1.3	-0.0	0.3
Depression (self-reported)	0.5	0.6	1.7	0.6	1.3	0.4	-0.1
Medication: Lansoprazole	1.5	1.7	4.8	-0.1	2.2	-1.0	-1.1
Prospective memory result	1.5	1.9	4.4	-1.3	2.1	-0.9	-0.8
Lung cancer (father)	2.9	3.4	6.9	1.5	0.3	-2.6	2.0
Illnesses of mother	1.0	1.2	2.9	-1.3	0.4	-0.3	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.0	0.5	0.3	-0.2
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	1.5	0.5	-0.9	0.8
Impedance of arm (left)	0.1	0.6	1.5	0.3	-0.8	0.4	1.2
Arm fat mass (right)	0.1	0.3	0.9	0.0	-0.0	0.3	1.0
Trunk predicted mass	0.0	0.2	0.4	-0.5	-0.5	0.6	-0.0
Standing height	0.1	0.9	1.6	-0.4	-1.0	1.3	0.8
Length of working week for main job	0.5	0.6	1.4	-0.4	0.2	-1.2	-0.8
Exposure to tobacco smoke at home	2.0	2.3	3.7	-0.8	1.9	-1.0	-1.9
Breastfed as a baby	1.1	1.3	2.8	-0.5	-1.7	-0.2	1.5
Tense / ‘highly strung’	1.0	1.6	3.6	-1.9	-0.5	-0.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	0.6	0.0	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.1	0.2	1.0	0.7
Birth weight of first child	0.1	0.3	0.4	-0.1	-0.5	0.6	0.7
Peak expiratory flow (PEF)	0.4	1.0	2.1	1.1	0.8	-0.2	1.4
Pulse wave reflection index	0.2	0.3	1.0	-0.4	-0.1	-1.0	-0.1
Ever highly irritable/argumentative for 2 days	1.0	1.3	3.4	-1.8	0.6	-0.0	-1.1
Loud music exposure frequency	0.1	0.1	0.4	-0.3	0.6	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.6	-0.4	1.7	-2.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	-0.1	-0.7	1.3	-1.2
Blood clot in the leg (DVT)	1.5	2.0	5.4	1.5	-0.3	0.2	-2.3
Medication: Paracetamol	0.2	0.3	0.7	-0.9	-0.0	0.5	0.6
Headache pain in last month	0.2	0.4	0.5	-0.7	-0.7	0.7	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.7	-0.5	1.3	0.2	-0.7
Glaucoma (self-reported)	1.3	1.5	5.3	2.3	-0.0	-0.6	-0.7
Gout (self-reported)	0.5	0.7	1.9	0.7	-0.5	0.5	-1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.3	0.0	-1.0	0.7
Medication: Amlodipine	0.3	0.4	0.8	0.9	-0.4	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.1	-2.0	0.9	-1.8	-0.3
Birth weight	0.6	1.4	2.9	0.6	1.7	-1.1	-0.9
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.5	1.2	1.1	-0.8	0.6
High blood pressure (siblings)	2.5	3.6	9.9	-1.2	-1.3	1.2	3.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.2	0.9	0.3	-0.5
Body fat percentage	0.1	0.3	0.6	0.5	0.3	0.4	0.8
Leg fat percentage (right)	0.1	0.5	0.9	0.9	0.6	0.1	1.0
Arm fat-free mass (right)	0.0	0.2	0.4	-0.3	0.5	-0.1	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.5	0.7	-0.4	0.6
Comparative body size at age 10	0.7	1.8	3.3	1.8	0.6	-0.6	-1.8
Number of full brothers	0.7	0.9	3.0	-1.7	-0.8	0.2	0.3
Worry too long after embarrassment	0.5	0.9	1.3	0.5	0.9	-1.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.8	-2.0	0.8	-0.1	0.3
Wheeze or whistling in the chest in last year	2.0	3.5	6.4	-2.5	2.5	-1.0	-0.8
Number of children fathered	0.2	0.3	0.8	0.9	0.6	0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.3	1.8	-0.2	-0.0	0.4
Age at first live birth	0.9	1.7	4.8	1.2	-0.1	0.6	2.2
Pulse wave peak to peak time	1.0	1.2	2.4	-1.5	-0.8	1.2	-0.6
Health satisfaction	0.4	0.5	0.9	-0.4	0.8	-0.5	0.9
Shortness of breath walking on level ground	0.1	0.1	0.4	0.3	0.2	0.6	0.2
Qualifications: College or University degree	0.3	0.9	2.4	1.6	0.5	-0.0	0.9
Eye problems/disorders: None of the above	0.8	1.0	2.0	-1.4	0.7	-0.2	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-0.4	1.3	-1.3	-0.3
Emphysema/chronic bronchitis	0.6	0.7	1.7	-0.9	0.3	0.2	-1.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.1	0.4	0.8	-1.4	-0.4
Neck or shoulder pain in last month	1.5	2.1	3.2	-1.5	1.4	-1.8	-1.0
Medication: Blood pressure	0.3	0.6	1.7	0.8	-1.3	0.2	0.3
Angina (self-reported)	0.3	0.4	1.4	1.2	0.4	-0.3	0.0
Migraine (self-reported)	2.2	2.7	6.8	0.0	-1.7	2.6	1.1
Medication: Ibuprofen	1.5	1.8	3.4	-1.9	-1.8	0.5	0.6
Medication: Allopurinol	0.5	0.7	1.6	-0.6	-1.3	0.9	-0.4
Medication: Omeprazole	0.1	0.1	0.5	-0.7	-0.1	0.1	0.0
Medication: Seretide 50 evohaler	0.8	0.9	3.3	-0.5	1.8	0.1	0.4
Mean time to correctly identify matches	1.5	2.9	4.6	1.7	-1.2	2.1	1.6
Heart disease (mother)	1.1	1.3	3.4	1.9	1.0	-0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.3	1.5	0.0	-0.4	-0.6
Whole body fat mass	0.1	0.3	0.8	0.4	0.2	0.4	0.9
Leg fat mass (right)	0.1	0.3	0.7	0.5	0.5	0.2	0.8
Arm predicted mass (right)	0.0	0.2	0.4	-0.4	0.6	-0.3	-0.4
Pulse rate, automated reading	0.2	0.5	1.2	-1.1	0.4	0.9	0.1
Alcohol intake frequency.	1.4	3.3	6.8	-0.4	-1.1	2.2	2.6
Comparative height size at age 10	0.1	0.3	0.8	0.5	0.9	-0.4	-0.4
Number of full sisters	0.2	0.2	0.4	-0.5	0.3	-0.6	-0.2
Suffer from ‘nerves’	0.7	1.1	1.3	-1.1	-1.1	1.0	1.1
Overall health rating	0.1	0.1	0.3	-0.5	-0.0	0.5	0.1
Chest pain or discomfort	0.6	0.9	2.7	-0.6	1.6	-0.7	0.5
Had major operations	0.7	0.8	2.6	0.5	0.3	0.6	1.6
Age at last live birth	1.2	1.8	4.5	1.5	0.1	0.5	2.1
Family relationship satisfaction	2.1	2.6	7.8	-2.8	-1.0	0.8	1.0
Leg pain on walking	1.6	2.0	4.3	1.1	2.1	-1.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-1.3	-1.1	-0.1	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	0.7	0.0	-0.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.7	-0.5	1.0	0.5
Medication: Aspirin	1.6	2.1	5.1	0.9	-2.3	1.6	0.2
Supplements: Vitamin C	0.3	0.3	0.7	-0.8	0.1	0.7	0.4
Knee pain experienced in last month	0.7	1.2	1.8	0.6	-0.8	1.4	1.3
Hypertension (Self-reported)	0.3	0.9	2.2	-0.5	0.2	-1.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	1.5	0.8	0.8	-0.8	-1.2
Illnesses of father: Heart disease	0.9	1.2	4.5	0.3	-0.5	2.1	0.4
Illnesses of siblings: Diabetes	5.6	6.8	13.5	-1.9	-2.4	2.1	3.7
Smoking status: Previous	1.0	1.5	4.1	-0.6	0.5	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.1
Whole body fat-free mass	0.0	0.1	0.3	-0.6	-0.2	0.4	-0.1
Leg fat-free mass (right)	0.0	0.2	0.7	-0.8	0.2	0.5	0.1
Arm fat percentage (left)	0.0	0.1	0.4	0.1	0.2	0.1	0.7
Average weekly red wine intake	0.2	0.3	1.4	0.2	-1.2	0.0	0.0
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.6	2.1	-1.1	2.4	0.8
Mood swings	1.1	1.9	6.9	-2.6	-0.5	0.3	-0.7
Loneliness, isolation	0.5	0.6	1.0	-0.6	-0.5	1.0	0.9
Long-standing illness, disability or infirmity	0.8	1.3	3.5	-0.8	-1.0	0.2	1.9
Ever had bowel cancer screening	0.3	0.4	1.0	0.6	0.4	0.2	1.0
Diabetes diagnosed by doctor	0.8	1.3	2.6	0.7	-1.6	1.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	-0.7	1.3	0.3	-0.1
Friendships satisfaction	1.3	1.6	2.6	-1.6	-1.2	1.3	0.7
Qualifications: nursing, teaching	0.8	1.2	2.1	1.3	1.4	-0.9	0.5
Commuting to job workplace: Walk	0.4	0.4	1.5	1.2	0.2	-0.2	-0.2
Eye problems/disorders: Cataract	0.5	0.6	1.4	-0.6	-0.5	-0.3	1.2
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.3	-1.8	1.0	-1.2	-1.4
Medication for cholesterol	0.4	0.6	1.2	0.2	0.5	0.9	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	8.5	-2.9	0.5	1.5	0.1
Back pain experienced in last month	0.7	1.0	2.2	-1.5	1.2	-0.6	0.1
Mineral and other dietary supplements	0.9	1.2	3.6	-0.6	-0.9	0.0	-1.9
Breast cancer (self-reported)	0.2	0.2	0.9	-0.3	-0.0	-0.9	-0.1
Asthma (self-reported)	0.9	1.7	4.6	-2.1	1.4	-0.6	0.5
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.1	0.8	-0.1	0.6
Osteoarthritis (self-reported)	0.5	0.6	1.3	0.8	-0.6	-0.1	1.2
Medication: Aspirin	1.1	1.5	3.9	1.0	-2.0	1.0	0.1
Medication: Gliclazide	0.5	0.6	1.1	1.1	-0.7	0.2	-0.9
Illnesses of father: None of the above (group 1)	0.6	0.8	1.9	0.7	0.0	-1.4	0.7
Smoking status: Current	3.3	5.2	13.8	-3.7	1.2	-1.2	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	0.7	0.3	-0.8	0.5
Whole body water mass	0.0	0.1	0.3	-0.6	-0.1	0.3	-0.2
Leg predicted mass (right)	0.0	0.3	0.8	-0.9	0.2	0.5	0.1
Arm fat mass (left)	0.0	0.2	0.7	0.2	-0.0	0.2	0.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.9	0.4	0.5	-1.7	0.6
Average weekly champagne plus white wine intake	0.8	1.1	3.6	-0.2	1.9	0.1	-0.9
Miserableness	1.3	2.2	4.0	-1.2	-1.5	2.0	1.0
Guilty feelings	1.0	1.5	3.6	-1.3	-1.0	-0.2	1.9
Wears glasses or contact lenses	0.3	0.3	0.8	-0.5	-0.9	0.5	0.3
Ever taken oral contraceptive pill	0.5	0.6	1.3	0.6	0.8	-1.1	-0.3
Hearing aid user	2.3	2.6	6.2	-0.3	1.3	-1.6	-2.5
Mother’s age at death	0.9	1.2	2.2	1.5	1.1	-0.9	-0.8
Financial situation satisfaction	1.0	1.2	3.6	-1.9	0.4	1.0	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	0.6	1.0	-0.9	-0.6
Commuting to job workplace: Public transport	1.3	1.6	3.0	-0.5	-1.7	1.5	0.9
Eye problems/disorders: Glaucoma	0.6	0.7	2.4	1.5	-0.7	-0.3	-0.3
Medication: Blood pressure	1.1	2.1	4.7	-0.7	1.1	-2.2	-1.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	-0.1	1.4	-1.3	0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.8	6.3	0.1	0.1	0.9	2.5
High cholesterol (Self-reported)	0.9	1.5	3.1	-0.0	-1.8	0.3	1.7
Medication: Bendroflumethiazide	0.4	0.7	2.1	0.4	0.4	-1.5	0.4
Medication: Paracetamol	0.2	0.4	0.7	-0.9	-0.1	-0.1	0.8
Medication: Lisinopril	1.1	1.4	4.0	-2.0	0.9	-0.8	-0.1
Medication: Atorvastatin	2.0	2.5	8.6	-2.9	-0.6	0.9	-0.6
Illnesses of father: High blood pressure	0.6	0.7	1.7	0.5	0.9	0.2	-1.3
Alcohol drinker status: Never	0.2	0.2	0.2	-0.5	0.5	-0.3	0.5
Ever smoked	2.0	3.5	6.0	-2.4	1.1	-1.5	-2.1
Basal metabolic rate	0.0	0.1	0.3	-0.5	-0.2	0.5	0.1
Leg fat percentage (left)	0.2	0.6	1.3	0.5	0.8	0.2	1.2
Arm fat-free mass (left)	0.0	0.2	0.5	-0.7	-0.2	0.5	0.0
Number of operations (self-reported)	0.9	1.3	2.4	1.5	1.0	-0.8	1.2
Average weekly beer plus cider intake	0.8	1.2	4.0	0.5	2.0	-0.7	-0.1
Irritability	1.4	2.4	9.4	-3.1	0.1	0.2	0.5
Risk taking	0.2	0.4	0.7	0.2	0.2	0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.1	-0.5	-0.1	-0.0
Fractured/broken bones in last 5 years	2.1	2.7	4.3	-0.8	1.8	-2.1	-1.7
Age started oral contraceptive pill	1.5	1.9	4.6	2.1	0.0	-0.1	1.8
Diastolic blood pressure, automated reading	0.4	1.3	4.0	-2.0	-0.7	0.8	0.4
Ever depressed for a whole week	0.3	0.3	1.0	-0.4	0.4	-1.0	-0.1
Unable to work because of sickness or disability	0.4	0.5	0.8	-0.7	-0.7	0.9	0.5
Commuting to job workplace: Cycle	0.6	0.7	2.3	0.4	-0.7	0.2	1.5
Myopia	1.2	1.8	3.7	0.3	1.3	-1.9	-1.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	1.2	0.0	1.3	1.0
Cholesterol lowering medication	0.8	1.2	4.2	0.2	-0.8	0.2	2.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.7	0.1	-0.2	-0.1
Pain experienced in last month	1.1	1.9	4.2	0.7	1.0	-2.0	-1.4
Supplements: Calcium	0.4	0.4	1.2	0.1	0.6	0.2	-1.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	0.1	-1.1	-0.1	0.9
Heart attack/myocardial infarction (self-reported)	2.8	3.6	5.0	1.8	2.0	-1.3	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	5.9	1.9	-0.1	0.0	-2.4
Heart disease (siblings)	1.4	1.7	3.1	-1.7	-1.2	0.9	1.2
Alcohol drinker status: Previous	2.7	3.1	5.1	-1.3	-2.3	1.2	2.0
Pack years of smoking	0.7	1.0	2.0	-1.4	-1.3	0.6	-0.0
Impedance of whole body	0.1	0.3	0.6	0.4	-0.5	0.2	0.8
Leg fat mass (left)	0.1	0.4	1.0	0.4	0.6	0.2	1.0
Arm predicted mass (left)	0.0	0.2	0.6	-0.8	-0.0	0.2	0.1