Hub : Genes

CEP128

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2020	0.0400	4.6e-14	0.072	0.150	0.141	0.152	0.103	4.2e-09	8.2e-18	9.1e-17	4.2e-18	1.6e-12
2	GTEx	Brain Cerebellar Hemisphere	0.2830	0.0880	7.1e-04	0.031	NA	0.100	NA	0.001	5.6e-02	NA	1.6e-03	NA	3.1e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1620	0.0540	1.3e-03	0.105	NA	0.054	NA	0.003	2.3e-06	NA	6.0e-04	NA	2.1e-01
4	GTEx	Testis	0.2430	0.0680	1.2e-06	0.175	NA	0.138	NA	0.174	3.4e-08	NA	1.1e-06	NA	3.5e-08
5	ROSMAP	Brain Pre-frontal Cortex	0.0819	0.0254	3.9e-07	0.025	0.055	0.041	0.056	0.041	2.7e-04	1.2e-07	4.3e-06	9.6e-08	5.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.4	0.6	0.8	-0.8	-0.0	-0.7	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	-1.1	-1.0	0.2	0.4	-1.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.7	-0.5	-0.6	-0.7	1.6	-0.6
Depression (Nagel 2018)	2.2	3.3	11.2	-0.4	-1.1	-0.5	3.4	-1.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	0.1	-0.6	-0.1	-0.5	1.5
Neuroticism (Nagel 2018)	0.9	2.2	8.6	-1.0	-1.0	-0.2	2.9	-0.6
Schizophrenia (2018)	0.8	1.7	4.0	-2.0	-0.6	0.2	1.0	-1.7
Schizophrenia vs Biploar Disorder	2.9	3.8	8.6	-2.9	-0.9	-0.4	1.6	-2.7
Worry (Nagel 2018)	1.5	3.1	9.2	-1.6	-1.4	0.4	3.0	-1.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.3	0.7	0.1	0.1	0.9
Alzheimer’s Disease (in father)	0.7	0.8	2.0	-0.2	-1.0	0.3	1.4	-0.9
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.1	0.2	0.7	0.4	0.4
Crohns Disease (2017)	0.2	0.5	1.0	1.0	-0.7	0.9	0.1	0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.3	1.1	0.0	1.0	-0.0	0.9
Ulcerative Colitis (UC)	0.5	0.9	1.9	0.9	0.8	1.0	-0.3	1.4
Major Depression (MDD)	0.3	0.4	0.7	-0.5	0.4	0.8	-0.1	-0.9
Reaction Time	3.1	5.9	12.2	-2.1	-2.0	-1.1	3.5	-2.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.3	0.3	-1.0	-1.0	-1.5	1.5
Breast Cancer	1.4	3.3	10.2	-3.2	-0.8	-0.1	1.8	-1.6
Ovarian Cancer	0.4	0.5	1.0	0.7	0.5	0.2	-1.0	1.0
Prostate Cancer	0.1	0.2	0.3	0.4	-0.5	-0.6	-0.4	0.2
Age at First Birth	0.3	0.4	0.9	0.4	0.3	-0.6	-0.9	0.9
Bipolar Disorder (2011)	0.7	0.7	1.2	1.1	0.4	0.7	-0.7	1.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.9	0.0	0.1	-0.3	-0.8
Coronary Artery Disease (CAD)	1.3	1.5	2.1	1.0	1.2	1.4	-1.2	1.3
Crohns Disease (2012)	0.6	1.0	1.7	1.3	-0.7	1.2	0.5	0.9
Mean Putamen Volume	4.8	5.5	7.6	2.8	2.7	2.1	-1.5	2.4
Fasting Glucose	2.5	2.9	7.1	-0.0	-2.7	-1.5	0.7	-2.2
HbA1C	0.5	0.5	1.7	0.4	-0.3	-0.0	1.3	-0.7
HDL Cholesterol	0.2	0.4	0.9	-0.8	0.2	-1.0	0.4	-0.1
LDL Cholesterol	0.1	0.2	0.6	-0.1	0.1	-0.2	-0.8	-0.4
Lupus	0.1	0.1	0.2	0.4	-0.4	0.1	-0.0	-0.4
Neuroticism (2016)	0.7	1.1	3.8	-0.4	0.0	1.1	2.0	0.4
Primary Biliary Cirrhosis	0.2	0.3	1.1	1.0	-0.5	-0.4	-0.2	0.3
Rheumatoid Arthritis	0.5	0.7	2.1	-0.3	0.1	-1.4	-0.5	-1.1
Schizophrenia (2014)	0.7	1.5	2.9	-1.5	-1.1	0.6	0.8	-1.7
Triglycerides	0.6	1.0	2.3	0.8	1.2	1.5	-0.5	0.8
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.6	-0.2	2.1	1.0	-1.1	1.9
Ulcerative Colitis	0.2	0.4	1.0	1.0	-0.1	0.0	0.3	0.8
Blood Eosinophil Count	0.0	0.3	0.9	-0.2	0.9	-0.2	-0.5	-0.5
Blood Platelet Count	0.7	8.1	31.5	1.4	5.6	2.3	-1.3	0.5
Blood Red Count	0.1	0.5	1.1	-0.5	0.3	-0.9	-0.6	-1.1
Blood White Count	0.2	1.2	2.7	-0.2	1.7	0.3	0.4	-1.6
Heel T-Score	0.5	4.0	9.6	1.7	-0.1	-2.4	-3.1	1.3
BMI	0.5	3.1	5.6	1.4	1.8	1.0	-1.9	2.4
Height	0.0	0.8	1.7	-1.3	1.1	1.1	0.0	-0.2
Waist Hip Ratio (WHR)	0.3	1.5	2.8	1.3	1.7	0.7	-1.0	1.1
Systolic Blood Pressure	0.5	2.4	4.9	2.0	0.2	0.3	-2.2	1.6
Smoking Status	1.8	4.3	9.4	2.5	3.1	0.1	-2.0	1.4
Allergy or Eczema	0.6	1.5	4.5	2.1	0.5	0.4	-0.1	1.6
Cardiovascular Disease	0.1	0.3	0.9	1.0	0.5	0.0	-0.5	-0.1
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.5	-0.8	0.2	1.4	-1.3
Respiratory disease	0.4	0.9	3.6	0.3	-0.2	-0.3	1.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	1.0	0.7	0.3	-0.1	1.3
Lung FEV1/FVC ratio	1.0	5.2	9.6	1.9	1.1	2.0	-2.7	3.1
Lung FVC	0.3	1.5	3.4	0.9	0.6	-0.4	-1.8	1.7
Neuroticism	1.5	3.7	10.2	-1.9	-1.9	-0.5	3.2	-1.0
Chronotype (morning person)	0.3	0.8	2.0	-0.2	1.2	0.4	-0.4	1.4
Hair Pigment	0.0	0.5	1.6	-1.2	0.4	-0.4	0.6	-0.7
Tanning	0.1	0.9	2.0	1.4	0.1	-1.4	-0.4	0.8
Hand grip strength (left)	1.0	2.5	5.5	0.6	1.5	0.6	-2.3	2.1
Number of treatments/medications taken	0.4	0.7	2.6	0.2	-0.4	0.8	1.6	-0.4
Average weekly spirits intake	1.3	1.6	3.6	-1.9	-1.2	-0.7	1.2	-0.8
Sensitivity / hurt feelings	0.3	0.5	2.1	-0.3	0.1	-0.5	1.4	0.1
Frequency of depressed mood in last 2 weeks	2.1	2.9	8.4	-0.2	-1.0	-0.9	2.9	-2.0
Hearing difficulty/problems: Yes	3.1	4.8	7.9	2.2	2.5	1.5	-1.6	2.8
Relative age of first facial hair	0.1	0.2	0.5	0.1	-0.5	-0.7	0.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	0.9	0.0	1.3	1.0	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.5	-0.1	0.8	0.4	-1.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	-0.5	0.6	1.3	0.5	-0.3
Systolic blood pressure, automated reading	0.6	1.8	2.9	1.7	1.1	1.3	-0.9	1.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	0.4	-0.7	0.9	1.2	-0.2
Angina	0.5	0.6	1.6	-0.5	-0.1	0.2	1.3	-1.1
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.1	0.6	0.8	0.2	-0.0
Vitamin and mineral supplements	1.4	2.0	4.1	-1.4	-1.4	-0.3	1.3	-2.0
Supplements: Zinc	0.1	0.2	0.5	0.4	0.0	0.2	0.7	0.3
Medication: Co-codamol	1.3	1.5	2.9	-0.3	-1.7	-1.3	1.0	-1.4
Medication: Metformin	0.4	0.6	1.6	0.6	-1.2	-1.0	-0.5	-0.2
Diabetes (father)	0.4	0.4	1.0	0.8	-0.2	1.0	0.4	-0.6
Diabetes (mother)	0.3	0.4	1.6	0.5	0.2	-0.3	-1.3	-0.2
Severe depression (siblings)	0.9	1.0	2.3	-0.5	-1.0	-1.5	-0.2	-1.2
Pack years adult smoking proportion	1.4	2.1	3.0	1.7	1.4	1.2	-1.7	1.2
Impedance of leg (right)	1.7	8.0	12.3	-2.1	-2.7	-3.2	2.5	-3.5
Leg fat-free mass (left)	1.2	6.5	10.2	1.8	2.1	2.4	-3.0	3.2
Trunk fat percentage	0.9	3.4	6.3	1.4	1.9	1.4	-2.5	1.8
Hand grip strength (right)	1.4	3.9	7.3	1.2	1.8	0.9	-2.7	2.6
Townsend deprivation index at recruitment	0.2	0.3	1.1	0.5	1.0	-0.1	-0.3	0.0
Current tobacco smoking	0.9	1.4	3.0	1.3	0.5	-1.7	-1.4	-0.2
Average weekly fortified wine intake	2.7	3.1	7.5	-0.6	-1.8	-0.0	2.7	-2.1
Maternal smoking around birth	1.0	1.5	2.4	-1.1	-1.4	-1.6	0.7	-1.2
Fed-up feelings	1.6	3.0	4.1	-1.3	-1.4	-2.0	1.8	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.4	0.2	-0.5	-1.0	1.2	-1.0
Relative age voice broke	0.4	0.6	0.9	1.0	0.2	-0.5	-0.9	0.9
Taking other prescription medications	0.8	1.2	4.1	0.8	-1.1	0.4	2.0	-0.1
Age when periods started (menarche)	0.2	0.6	1.4	-1.2	-0.5	-0.2	0.7	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	-0.0	-0.4	-0.2	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.5	0.8	0.3	-0.3	-1.2	0.4
Tinnitus: Yes, but not now, but have in the past	4.8	5.1	11.4	-3.4	-1.9	-1.7	2.2	-1.9
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-1.1	-0.7	-0.6	0.2	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.0	0.2	-0.2	0.1	0.9	-1.0
High blood pressure	0.2	0.5	1.7	1.3	-0.6	0.1	-0.3	-0.6
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.4	2.3	1.0	0.7	-1.2	1.9
Multivitamins +/- minerals	3.7	4.6	7.4	2.7	2.2	0.5	-1.9	2.7
Stomach or abdominal pain in last month	2.1	2.6	6.7	-0.4	-1.1	-0.7	2.6	-2.1
Supplements: Glucosamine	3.2	4.2	7.1	1.6	2.7	2.2	-0.7	2.5
Diverticular disease/diverticulitis (self-reported)	7.2	8.6	10.6	3.1	3.0	1.9	-3.2	3.2
Medication: Atenolol	0.2	0.2	0.5	0.3	-0.7	0.1	0.6	-0.4
Medication: Levothyroxine sodium	3.0	5.1	10.9	-1.6	-2.1	0.8	3.3	-2.7
Sitting height	0.4	2.6	6.9	-0.2	-2.6	-1.7	-0.5	-1.7
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	0.1	1.1	-0.6	0.2	-0.0
High blood pressure (mother)	1.2	1.6	4.0	1.8	0.8	0.2	-2.0	-0.1
Body mass index (BMI)	2.5	10.5	15.4	2.7	3.1	2.8	-3.5	3.9
Impedance of leg (left)	1.7	8.5	13.4	-2.4	-2.4	-2.9	2.9	-3.7
Leg predicted mass (left)	1.2	6.6	10.6	1.8	2.1	2.5	-2.9	3.3
Trunk fat mass	1.2	5.2	8.1	1.4	2.4	2.0	-2.8	2.5
Waist circumference	1.7	6.4	8.4	1.7	2.7	2.2	-2.9	2.8
Number of incorrect matches in round	1.4	2.3	6.7	-0.3	2.6	2.1	0.3	-0.2
Past tobacco smoking	2.1	3.9	9.7	-1.9	-3.1	-1.0	1.3	-1.9
Alcohol usually taken with meals	0.2	0.3	0.9	-1.0	-0.6	0.2	-0.5	-0.2
Nervous feelings	1.3	2.4	3.8	-1.8	-1.8	-0.6	1.9	-1.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	7.9	-0.6	-1.7	-1.8	2.8	-1.3
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.1	0.9	-0.4	0.4	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.2	0.9	-0.4	-0.1	-0.2
Had menopause	1.1	1.4	4.8	-0.3	-0.9	-0.1	2.2	-1.2
Had other major operations	0.9	1.1	3.7	0.6	0.5	1.9	0.7	0.8
Forced vital capacity (FVC)	0.2	0.8	1.4	-0.2	-1.2	-1.1	-1.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.2	0.6	0.3	-0.8	-1.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.7	1.3	1.1	0.6	-0.7	-0.4
Qualifications: None of the above	0.7	1.5	6.6	0.8	2.6	0.5	-0.0	-0.5
Financial difficulties in last 2 years	0.2	0.3	1.1	0.3	-0.3	-0.3	0.2	-1.1
Mouth/teeth dental problems	0.5	0.8	2.1	0.7	0.6	0.3	-1.1	1.4
Heart attack	1.0	1.3	2.4	-1.2	-1.2	-1.0	0.3	-1.6
Allergy	0.4	0.8	2.8	-1.7	-0.3	0.3	0.1	-1.1
Pain all over the body in last month	0.8	0.8	2.7	-0.6	0.0	0.6	1.7	-0.9
Diabetes (self-reported)	0.2	0.3	0.6	0.7	-0.1	0.7	0.8	0.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.7	1.3	1.5	1.2	-1.4	1.9
Medication: Ramipril	0.7	0.9	3.2	0.8	-0.5	-0.3	-1.8	0.6
Medication: Simvastatin	0.4	0.7	2.9	0.1	-0.3	1.7	0.4	-0.4
Fluid intelligence score	0.6	1.3	2.2	-0.2	-1.5	-1.2	-1.3	1.0
Illnesses of siblings	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.3	-0.0
Neuroticism score	0.7	1.4	5.1	-1.1	-0.8	-0.3	2.3	-0.2
Weight	1.8	8.8	12.3	2.0	2.9	3.1	-3.2	3.5
Impedance of arm (right)	1.0	4.9	9.7	-1.2	-2.4	-2.3	1.5	-3.1
Arm fat percentage (right)	1.6	6.3	11.0	2.2	2.3	1.9	-3.3	2.6
Trunk fat-free mass	0.8	4.8	8.3	0.9	2.3	2.5	-1.8	2.9
Hip circumference	1.2	5.0	8.1	1.4	2.2	1.9	-2.8	2.6
Time employed in main current job	0.3	0.4	0.9	0.8	-0.2	-0.2	-0.9	-0.4
Alcohol intake versus 10 years previously	0.3	0.4	1.2	-0.9	1.1	0.5	0.0	0.0
Father’s age at death	2.8	3.7	6.2	-1.8	-1.5	-1.3	2.2	-2.5
Worrier / anxious feelings	0.1	0.2	0.6	0.2	0.0	-0.7	0.8	-0.1
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	9.4	-0.9	-1.9	-1.1	3.1	-1.5
Falls in the last year	0.4	0.5	1.4	-0.1	0.3	0.7	1.2	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	-0.8	-0.7	1.3	1.0	0.2
Number of live births	2.9	4.1	8.0	-2.0	-1.4	-1.3	2.8	-2.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.8	-0.0	-0.9	-0.3	-1.7	0.8
Pulse rate	0.4	0.7	0.9	-0.7	-0.9	-0.7	0.9	-1.0
Happiness	0.9	1.1	3.1	-0.6	-0.8	-0.1	1.8	-1.2
Noisy workplace	0.8	1.0	2.8	0.9	0.7	0.3	-1.7	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.2	0.2	-1.8	-1.6	-0.4	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	0.4	1.1	1.1	0.3	0.5
Mouth/teeth dental problems: Dentures	1.5	2.6	5.1	-1.7	-0.9	-1.0	1.7	-2.2
Asthma	0.2	0.5	1.3	0.7	-0.2	-0.6	1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.0	-2.2	-0.1	-1.1	1.1	-1.2
Medication: Cholesterol lowering	0.4	0.6	1.2	0.9	1.1	0.4	-0.7	0.2
Depression (self-reported)	0.4	0.4	1.2	-0.1	-1.1	-0.7	0.7	-0.2
Medication: Lansoprazole	0.3	0.3	0.7	-0.1	0.3	-0.8	0.8	0.3
Prospective memory result	0.7	0.8	1.2	-0.9	0.4	-1.1	0.7	-1.1
Lung cancer (father)	3.8	4.4	7.5	-2.7	-1.5	0.3	2.7	-2.1
Illnesses of mother	0.2	0.2	0.8	-0.9	0.0	0.1	0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	-0.5	-1.2	-0.8	-0.5	0.4
Pulse wave Arterial Stiffness index	0.8	0.9	1.5	-1.1	-0.7	-0.6	0.9	-1.2
Impedance of arm (left)	1.1	5.2	10.0	-1.5	-2.3	-2.5	1.5	-3.2
Arm fat mass (right)	2.0	8.2	12.1	2.2	2.7	2.3	-3.5	3.4
Trunk predicted mass	0.9	5.0	8.5	1.0	2.4	2.5	-1.9	2.9
Standing height	0.0	0.5	1.5	-1.2	-0.2	0.5	0.4	-0.6
Length of working week for main job	2.2	2.5	4.8	1.6	1.4	2.2	-1.1	1.3
Exposure to tobacco smoke at home	1.4	1.6	3.4	1.1	1.0	1.8	-0.5	1.5
Breastfed as a baby	0.5	0.6	1.1	0.8	1.0	-0.4	-0.6	1.0
Tense / ‘highly strung’	1.0	1.7	5.5	-1.2	-0.7	0.2	2.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.6	-0.6	0.1	0.8	-0.9
Hair/balding pattern: Pattern 4	0.7	1.7	3.8	1.9	-0.0	0.3	-1.1	1.8
Birth weight of first child	2.6	4.8	9.8	-2.4	-1.5	-1.0	2.2	-3.1
Peak expiratory flow (PEF)	1.5	3.5	9.0	1.2	0.3	-0.2	-3.0	2.6
Pulse wave reflection index	1.4	1.7	2.9	-1.7	-0.8	-1.2	1.0	-1.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.9	0.9	0.8	0.2	-0.1
Loud music exposure frequency	0.7	0.7	1.7	-1.3	-0.5	0.5	0.2	-1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	3.2	-1.2	-1.8	-1.1	0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.7	-0.1	-0.8	0.3	0.6	-0.8
Blood clot in the leg (DVT)	1.7	2.3	7.7	-1.5	-0.2	0.9	2.8	-0.6
Medication: Paracetamol	2.9	4.8	8.1	-2.7	-0.8	-1.0	2.8	-2.7
Headache pain in last month	1.5	2.5	4.8	-1.9	-1.1	0.3	2.2	-1.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.1	-0.9	-1.4	-0.8	1.3	-0.6
Glaucoma (self-reported)	0.4	0.4	1.6	-1.3	0.0	-0.1	0.6	0.1
Gout (self-reported)	1.0	1.3	3.2	-0.2	-1.8	-0.5	1.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.9	-0.8	-0.7	0.2	1.7	-1.3
Medication: Amlodipine	2.4	3.3	10.5	1.3	1.7	0.1	-3.2	1.2
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.3	-1.1	-0.9	-0.5	2.3	-1.6
Birth weight	0.3	0.6	1.3	-0.8	-0.9	-0.3	0.6	-1.1
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.2	-1.2	-1.2	0.3	2.1	-1.1
High blood pressure (siblings)	0.1	0.1	0.4	0.4	0.6	0.1	0.0	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	-0.7	-1.2	-1.1	0.0	-0.1
Body fat percentage	0.9	3.4	6.4	1.4	1.8	1.4	-2.5	1.9
Leg fat percentage (right)	1.3	4.8	6.5	1.7	2.4	1.6	-2.5	2.5
Arm fat-free mass (right)	1.1	5.7	10.1	1.1	2.5	2.4	-2.3	3.2
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.3	0.2	1.0	0.9	-0.3
Comparative body size at age 10	1.9	5.3	8.0	2.3	2.7	2.1	-1.4	2.8
Number of full brothers	0.3	0.4	0.9	-1.0	-0.2	-0.6	0.5	-0.8
Worry too long after embarrassment	0.8	1.4	2.7	0.8	1.6	1.0	0.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.0	0.0	-0.3	-0.2	1.4	-1.0
Wheeze or whistling in the chest in last year	0.3	0.4	1.5	-0.1	1.2	-0.6	-0.3	-0.6
Number of children fathered	0.9	1.0	3.6	0.4	1.9	0.7	0.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	4.4	1.5	0.1	-1.4	-2.1	0.8
Age at first live birth	1.0	1.8	4.3	0.9	-1.5	-2.1	-0.4	-1.0
Pulse wave peak to peak time	0.9	1.1	2.0	1.0	0.9	0.7	-0.9	1.4
Health satisfaction	1.8	2.4	10.4	0.2	0.3	0.7	3.2	-1.0
Shortness of breath walking on level ground	0.2	0.2	0.6	-0.1	0.8	0.4	0.2	-0.5
Qualifications: College or University degree	0.4	1.3	3.9	1.0	-0.6	-0.6	-1.0	2.0
Eye problems/disorders: None of the above	1.2	1.4	2.5	1.6	0.7	1.5	-1.2	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-0.9	0.9	1.3	0.2	0.1
Emphysema/chronic bronchitis	2.6	3.0	7.5	-1.0	-0.7	-2.7	0.7	-2.3
Medication for pain relief, constipation, heartburn	1.5	2.6	6.4	1.6	-0.4	-0.0	-2.5	1.9
Neck or shoulder pain in last month	2.2	3.1	8.7	-1.3	0.1	-1.3	2.9	-1.9
Medication: Blood pressure	1.6	2.8	5.1	2.0	1.6	0.7	-2.3	1.3
Angina (self-reported)	0.3	0.5	1.2	-0.3	-0.2	-0.0	1.0	-1.1
Migraine (self-reported)	2.6	3.2	9.9	-1.4	-0.7	0.4	3.1	-1.9
Medication: Ibuprofen	1.0	1.2	4.3	-2.1	0.2	-0.2	1.1	-0.5
Medication: Allopurinol	0.4	0.6	1.5	0.3	-1.1	0.2	1.2	0.2
Medication: Omeprazole	2.1	2.5	7.6	0.6	1.8	2.8	1.3	0.2
Medication: Seretide 50 evohaler	1.0	1.2	3.2	-0.2	-1.4	-1.8	0.6	-0.7
Mean time to correctly identify matches	2.3	4.4	9.9	-1.7	-1.6	-0.8	3.1	-2.5
Heart disease (mother)	1.3	1.6	3.4	-0.9	-1.5	-0.6	1.1	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	0.6	0.1	0.8	0.8	-0.3
Whole body fat mass	1.2	4.9	9.1	1.6	2.1	1.5	-3.0	2.5
Leg fat mass (right)	1.8	7.2	11.1	2.1	2.6	2.0	-3.1	3.3
Arm predicted mass (right)	0.9	4.5	8.4	0.9	2.2	2.1	-2.0	2.9
Pulse rate, automated reading	0.2	0.7	1.9	0.7	-0.0	1.4	0.4	1.0
Alcohol intake frequency.	0.3	0.7	2.7	-0.5	-0.2	0.1	0.5	-1.6
Comparative height size at age 10	0.3	1.6	3.7	-1.0	1.9	1.8	-0.1	0.2
Number of full sisters	1.0	1.2	3.3	-1.4	-0.4	-0.3	0.4	-1.8
Suffer from ‘nerves’	1.3	2.0	6.1	-0.9	-0.9	1.0	2.5	-1.1
Overall health rating	1.8	3.8	11.2	-0.4	-1.2	0.1	3.3	-2.5
Chest pain or discomfort	2.3	3.3	9.7	-0.8	-1.1	-0.7	3.1	-2.1
Had major operations	2.4	2.8	4.5	-1.3	-1.6	-2.1	1.1	-1.9
Age at last live birth	3.3	4.8	9.6	-0.3	-2.3	-3.1	1.2	-2.7
Family relationship satisfaction	0.6	0.8	2.3	-0.4	0.3	-0.3	1.5	-1.2
Leg pain on walking	2.3	2.9	6.6	-1.2	-0.3	-0.1	2.5	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.6	0.8	1.0	-0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.3	0.2	1.5	1.0	-0.8	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.3	-0.5	-1.0	-0.8	0.9
Medication: Aspirin	1.0	1.4	3.2	-0.3	-1.2	-0.0	1.5	-1.8
Supplements: Vitamin C	0.1	0.2	0.3	-0.5	-0.3	-0.4	-0.1	-0.6
Knee pain experienced in last month	0.4	0.7	1.0	0.7	0.9	0.9	1.0	-0.6
Hypertension (Self-reported)	0.3	0.7	2.7	1.6	-0.3	0.5	-0.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.7	1.4	1.1	0.9	-1.5	1.9
Illnesses of father: Heart disease	0.9	1.3	3.0	1.0	0.8	1.7	0.0	1.3
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.6	-0.3	-0.1	-0.2	0.8
Smoking status: Previous	1.8	2.7	5.3	1.6	2.3	1.2	-1.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.1	-1.1	-1.4	-0.8	1.4	-1.3
Whole body fat-free mass	1.0	5.5	9.2	1.2	2.3	2.5	-2.3	3.0
Leg fat-free mass (right)	1.0	5.6	8.1	1.5	2.1	2.7	-2.5	2.8
Arm fat percentage (left)	1.7	6.8	11.8	2.0	2.4	1.9	-3.4	2.9
Average weekly red wine intake	1.4	2.0	3.1	-1.7	-1.7	-1.3	1.5	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	-0.2	0.9	1.2	0.3	0.2
Mood swings	0.4	0.8	3.1	-0.1	0.3	-1.8	-0.0	-0.8
Loneliness, isolation	0.7	1.0	4.2	-0.3	-0.4	0.9	2.0	-0.1
Long-standing illness, disability or infirmity	1.0	1.6	3.5	-0.4	-1.5	-0.7	1.9	-1.2
Ever had bowel cancer screening	0.3	0.3	0.8	-0.9	-0.0	-0.6	0.6	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.2	-0.6	0.2	0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.5	-0.8	-0.8	0.0	-0.1
Friendships satisfaction	0.8	0.9	1.9	-1.4	-0.2	0.4	1.3	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.6	-0.1	-1.6	-1.4	0.0	0.4
Commuting to job workplace: Walk	0.5	0.5	1.1	-0.8	-1.1	-0.1	0.4	-0.8
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.1	0.9	-0.2	-1.1	1.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	3.4	1.2	1.8	1.6	-1.1	1.5
Medication for cholesterol	0.5	0.7	1.5	0.8	1.2	-0.2	-0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.6	-1.6	-0.2	-1.1	0.8	-0.5
Back pain experienced in last month	3.0	4.3	5.9	-1.6	-2.3	-2.2	1.7	-2.4
Mineral and other dietary supplements	2.0	2.8	5.2	-1.1	-2.3	-1.8	0.9	-1.8
Breast cancer (self-reported)	1.7	2.0	5.0	2.2	-0.9	-0.3	-1.8	0.9
Asthma (self-reported)	0.3	0.5	1.1	0.3	-0.3	-0.8	1.1	-0.8
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.7	-0.3	-0.0	-0.3	-0.3
Osteoarthritis (self-reported)	3.7	4.8	7.4	2.2	2.7	2.5	-0.4	2.3
Medication: Aspirin	0.7	0.9	2.1	0.2	-0.7	0.1	1.4	-1.4
Medication: Gliclazide	1.7	1.9	4.5	-0.8	-2.1	-1.0	1.0	-1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	3.5	-1.9	-0.8	-0.6	-0.2	-1.1
Smoking status: Current	0.8	1.3	2.9	1.0	0.8	-1.7	-1.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	-0.6	-0.7	0.4	-0.1	-0.5
Whole body water mass	1.1	6.2	9.9	1.4	2.5	2.7	-2.4	3.1
Leg predicted mass (right)	1.1	5.8	8.4	1.6	2.2	2.6	-2.6	2.9
Arm fat mass (left)	2.1	8.8	13.0	2.2	2.9	2.4	-3.6	3.5
Number of self-reported non-cancer illnesses	1.0	1.8	7.1	-0.1	-0.7	0.5	2.7	-1.0
Average weekly champagne plus white wine intake	0.5	0.6	1.1	-1.1	-0.4	-0.9	0.4	-0.9
Miserableness	0.1	0.1	0.2	-0.0	-0.3	-0.1	0.4	0.5
Guilty feelings	0.6	0.9	3.8	-0.2	-0.9	0.0	1.9	0.2
Wears glasses or contact lenses	0.3	0.3	0.5	-0.2	-0.5	-0.7	0.7	-0.6
Ever taken oral contraceptive pill	0.5	0.5	0.9	-0.2	-0.8	0.8	0.9	0.5
Hearing aid user	0.4	0.5	1.6	-0.6	0.2	-0.0	1.3	-0.6
Mother’s age at death	0.3	0.3	0.6	-0.1	0.7	0.5	-0.8	0.4
Financial situation satisfaction	0.8	1.0	3.1	-0.6	-0.6	-0.7	0.9	-1.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	0.8	0.3	1.3	-0.7	0.8
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.4	-0.1	0.3	-0.4	0.7
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.1	0.0	0.0	0.3	0.2
Medication: Blood pressure	1.0	1.8	3.4	-1.0	-1.6	-1.0	1.2	-1.8
Pain type(s) experienced in last month: Hip pain	2.7	3.4	5.3	-1.2	-1.1	-2.0	2.2	-2.3
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.2	1.6	2.9	1.8	-1.7	2.0
High cholesterol (Self-reported)	0.7	1.2	3.0	0.9	1.1	1.7	0.9	0.0
Medication: Bendroflumethiazide	0.2	0.3	1.1	-0.5	-0.5	-0.3	0.1	-1.0
Medication: Paracetamol	1.8	2.9	5.8	-2.4	0.2	-0.4	2.3	-1.7
Medication: Lisinopril	0.4	0.5	1.2	0.5	0.3	-0.9	-1.1	0.5
Medication: Atorvastatin	0.6	0.8	2.4	1.5	1.1	-0.3	0.1	0.4
Illnesses of father: High blood pressure	0.9	1.1	1.9	1.4	1.0	-0.4	-0.5	1.4
Alcohol drinker status: Never	0.3	0.4	1.1	-1.0	-0.1	-0.2	0.8	-0.4
Ever smoked	1.9	3.3	6.7	2.0	2.6	0.3	-1.6	1.7
Basal metabolic rate	1.2	6.5	10.2	1.5	2.5	2.7	-2.6	3.2
Leg fat percentage (left)	1.2	4.4	6.5	1.4	2.5	1.7	-2.2	2.4
Arm fat-free mass (left)	1.0	4.8	7.2	1.4	2.3	2.4	-2.0	2.7
Number of operations (self-reported)	0.9	1.4	2.2	-1.0	-1.1	-1.1	1.5	-1.1
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.3	0.3	0.0	0.4	0.1
Irritability	0.2	0.4	1.1	0.5	0.6	0.3	0.4	1.0
Risk taking	1.4	2.0	3.1	1.8	1.5	1.6	-0.5	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	-1.2	-0.8	-1.3	0.6	-0.8
Fractured/broken bones in last 5 years	1.6	2.1	4.2	1.6	2.1	1.6	-0.9	0.2
Age started oral contraceptive pill	0.3	0.3	1.0	0.2	-1.0	0.3	0.6	-0.5
Diastolic blood pressure, automated reading	1.4	4.4	8.2	2.4	1.3	1.6	-2.0	2.9
Ever depressed for a whole week	0.3	0.4	0.9	0.7	-0.4	0.3	-0.7	-0.9
Unable to work because of sickness or disability	0.7	0.9	2.3	-0.5	-0.3	-1.3	1.5	-0.4
Commuting to job workplace: Cycle	0.6	0.7	3.2	0.2	-0.2	-1.8	-0.4	0.1
Myopia	1.7	2.5	3.3	1.2	1.8	1.7	-1.2	1.8
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.8	0.6	-0.1	-0.0	0.8
Cholesterol lowering medication	0.7	1.0	2.9	-0.5	-1.1	0.3	1.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	13.1	0.7	2.1	3.6	1.4	0.7
Pain experienced in last month	2.0	3.4	8.2	1.0	1.1	0.9	-2.9	2.4
Supplements: Calcium	1.7	1.8	3.3	1.8	1.8	0.1	-1.0	1.2
Basal cell carcinoma (self-reported)	0.6	0.8	1.9	0.6	-0.3	0.9	1.4	-0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.8	-1.3	-0.9	-0.7	0.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	7.6	-1.4	-0.2	1.0	2.8	-0.6
Heart disease (siblings)	1.0	1.3	1.9	-1.1	-0.8	-1.4	1.4	-0.8
Alcohol drinker status: Previous	0.6	0.7	1.0	0.3	0.8	1.0	-0.7	1.0
Pack years of smoking	1.0	1.5	2.4	1.6	1.2	1.3	-1.1	0.9
Impedance of whole body	1.7	8.7	14.9	-2.2	-2.8	-3.2	2.4	-3.9
Leg fat mass (left)	1.8	7.1	10.6	2.0	2.7	2.1	-2.9	3.3
Arm predicted mass (left)	1.2	6.1	10.1	1.4	2.5	2.6	-2.3	3.2