TWAS hub - CEP152

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0250	2.4e-03	0.005	0.011	0.012	0.013	0.008	0.06700	0.016	1.1e-02	0.0096	2.9e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.3860	0.0900	7.1e-05	0.102	NA	0.167	NA	0.131	0.00032	NA	4.0e-06	NA	5.0e-05
3	GTEx	Esophagus Mucosa	0.2140	0.0830	2.0e-03	0.051	NA	0.035	NA	0.029	0.00026	NA	2.0e-03	NA	5.0e-03
4	GTEx	Nerve Tibial	0.1338	0.0490	2.9e-04	0.047	NA	0.030	NA	0.055	0.00027	NA	3.4e-03	NA	9.3e-05
5	TCGA	Brain Lower Grade Glioma	0.0462	0.0248	3.1e-04	0.011	0.023	0.031	NA	0.022	0.01700	0.001	1.6e-04	NA	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Aspirin	5.2	6.8	10.9	-2.2	3.1	3.3	1.9	2.2
Basal cell carcinoma (self-reported)	4.8	5.7	8.8	1.8	-2.3	-3.0	-2.4	-2.4
Medication: Aspirin	4.6	5.9	9.9	-2.2	3.0	3.1	1.6	1.9
Diastolic blood pressure, automated reading	3.3	10.3	45.8	-6.8	1.1	1.5	1.3	0.6
Mouth/teeth dental problems: Loose teeth	2.9	3.5	6.5	-0.6	1.6	1.4	2.4	2.6
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	5.0	-1.5	2.2	2.1	1.7	1.7
Reaction Time	2.6	5.0	12.0	-0.4	1.1	1.5	3.0	3.5
Father’s age at death	2.6	3.5	6.7	1.0	-1.6	-2.0	-1.8	-2.6
Medication: Cholesterol lowering	2.6	4.0	5.7	-2.4	1.8	2.2	1.8	1.8
Mean time to correctly identify matches	2.6	5.0	10.3	-0.6	1.3	1.6	3.2	3.2
Noisy workplace	2.5	3.0	8.5	-2.9	-1.7	-1.5	-0.4	-1.2
Comparative body size at age 10	2.5	7.0	12.0	1.8	-1.5	-2.4	-3.5	-3.4
Commuting to job workplace: Walk	2.5	2.7	6.8	1.5	-1.5	-2.6	-1.0	-1.2
Comparative height size at age 10	2.4	13.5	58.8	7.7	-2.6	-1.1	0.1	0.7
Diabetes (self-reported)	2.2	3.4	5.8	-1.4	2.4	2.1	1.6	1.5
Breastfed as a baby	2.2	2.7	6.7	-0.1	-1.1	-1.4	-1.9	-2.6
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	7.5	2.7	-1.1	-1.6	-1.8	-1.6
Medication for pain relief, constipation, heartburn	2.1	3.5	4.9	0.2	-1.9	-2.2	-2.1	-2.2
Crohns Disease (2012)	2.0	3.3	7.5	-0.5	0.8	1.5	2.4	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	3.6	0.3	1.9	1.8	1.3	1.7
Diabetes diagnosed by doctor	2.0	3.3	5.3	-1.6	2.3	1.6	1.8	1.7
Financial situation satisfaction	1.9	2.4	3.7	-0.5	-1.3	-1.9	-1.9	-1.7
High cholesterol (Self-reported)	1.8	3.1	5.2	-1.2	2.1	2.3	1.8	1.1
Body Mass Index (BMI) (2010)	1.7	2.4	6.8	-0.3	2.6	1.9	0.7	1.0
Maternal smoking around birth	1.7	2.5	3.9	-0.7	-2.0	-1.2	-1.7	-1.8
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.0	2.0	-0.5	0.0	-1.8	-1.6
Risk taking	1.7	2.5	5.0	0.8	-0.1	-1.7	-1.9	-2.2
Rheumatoid Arthritis	1.6	2.2	3.4	-1.5	-1.4	-0.7	-1.9	-1.7
Had menopause	1.6	2.0	3.2	0.4	1.1	1.6	1.8	1.8
Had major operations	1.6	1.9	3.7	1.9	-0.5	-1.4	-1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.0	3.0	-1.0	-1.9	-1.1	-1.2
Medication: Simvastatin	1.5	2.1	7.0	-2.6	0.3	0.8	1.6	0.5
Worrier / anxious feelings	1.5	2.8	5.6	-2.4	1.4	1.5	1.3	1.6
Prospective memory result	1.5	1.9	3.4	-1.8	1.1	1.7	1.2	0.8
Medication: Ibuprofen	1.5	1.8	6.8	2.6	-0.7	-1.0	0.4	0.6
Ulcerative Colitis (UC)	1.4	2.7	4.1	1.9	-1.4	-2.0	-1.3	-1.4
Height	1.4	26.6	118.8	10.9	-2.4	-1.6	1.9	1.4
Standing height	1.4	13.6	59.6	7.7	-1.5	-0.8	1.8	1.6
Pulse wave reflection index	1.4	1.8	4.0	-2.0	1.4	1.4	0.4	0.9
Wheeze or whistling in the chest in last year	1.4	2.6	4.2	-1.4	1.0	2.0	1.3	2.0
Mineral and other dietary supplements	1.4	1.9	3.7	1.9	0.6	0.6	1.4	1.8
Type 2 Diabetes (T2D) (2018)	1.3	2.4	2.9	-1.4	1.7	1.4	1.5	1.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	-0.5	1.9	1.9	0.1	-0.2
Financial difficulties in last 2 years	1.3	1.8	3.2	0.8	-0.9	-1.1	-1.8	-1.7
Mouth/teeth dental problems: Dentures	1.3	2.2	4.8	-1.3	-0.3	0.6	2.2	2.0
Depression (self-reported)	1.3	1.5	2.7	-1.6	-0.5	-0.9	-1.6	-1.1
Supplements: Calcium	1.3	1.4	2.6	-1.6	-1.1	-1.4	-0.6	-1.1
Hypothyroidism (self reported)	1.2	2.8	3.8	-1.7	-1.9	-1.9	-0.9	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.3	2.3	-0.1	-0.7	0.8	0.9
Pulse wave Arterial Stiffness index	1.2	1.4	3.1	-0.5	1.0	1.8	0.9	1.4
Age at first live birth	1.2	2.1	4.6	-0.4	1.2	0.8	2.0	2.1
Pulse wave peak to peak time	1.2	1.4	2.7	1.2	-1.0	-1.6	-0.8	-1.2
Age at last live birth	1.2	1.8	3.7	-0.9	1.2	0.6	1.6	1.9
Ovarian Cancer	1.1	1.4	3.0	-0.3	-0.5	-1.5	-1.2	-1.7
Lung FVC	1.1	5.8	15.7	-4.0	1.8	1.3	2.2	2.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.0	0.0	-1.2	-1.2	-1.1	-1.7
Supplements: Zinc	1.1	1.2	1.4	-1.1	1.0	1.2	1.0	1.2
Alcohol usually taken with meals	1.1	1.9	3.3	1.3	-0.6	-1.8	-0.9	-1.8
Medication: Blood pressure	1.1	1.9	5.4	-2.3	-0.1	1.0	1.3	1.1
Worry (Nagel 2018)	1.0	2.2	9.1	-3.0	0.6	1.1	0.1	0.3
Lung FEV1/FVC ratio	1.0	4.9	9.0	3.0	-2.0	-3.0	-1.4	-0.9
Medication for hormone replacement therapy	1.0	1.1	2.4	1.2	-0.3	0.7	-1.5	-1.0
Supplements: Glucosamine	1.0	1.3	2.8	-0.7	-1.1	-1.2	-0.6	-1.7
Medication: Atenolol	1.0	1.2	3.7	-0.3	1.3	1.9	0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.5	-0.4	-1.2	-1.2	-1.6	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.5	-0.1	1.6	1.1	1.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.4	-1.8	1.2	0.3	1.6	0.4
Emphysema/chronic bronchitis	1.0	1.2	4.8	-0.1	-0.1	-0.7	-0.7	-2.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.7	0.6	-0.6	0.1	1.7	1.4
Alcohol drinker status: Never	1.0	1.2	5.9	-2.4	0.1	-0.1	0.3	-0.1
Alcohol drinker status: Previous	1.0	1.1	2.3	-0.4	-0.9	-1.5	-1.0	-1.2
Pack years of smoking	1.0	1.4	3.0	-0.4	0.7	1.2	1.7	1.4
Cardiovascular Disease	0.9	3.1	5.4	-2.2	1.2	2.3	1.5	1.3
Medication: Metformin	0.9	1.3	2.3	-1.4	0.7	0.5	1.2	1.5
Mouth/teeth dental problems	0.9	1.3	3.5	1.9	-0.2	-0.5	-1.1	-1.3
Illnesses of mother	0.9	1.1	4.9	2.2	0.5	0.3	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	3.3	1.8	-1.1	-0.7	-0.0	-0.0
Shortness of breath walking on level ground	0.9	1.0	2.4	0.4	0.9	0.5	1.6	1.3
Heart disease (mother)	0.9	1.1	3.6	-0.4	-0.5	-0.5	-1.0	-1.9
Friendships satisfaction	0.9	1.1	3.5	-0.5	0.7	1.9	0.7	0.9
Breast cancer (self-reported)	0.9	1.1	2.9	1.7	-0.6	0.5	0.8	1.2
Medication: Atorvastatin	0.9	1.1	1.7	0.3	0.9	1.3	1.2	1.3
Commuting to job workplace: Cycle	0.9	1.1	2.5	0.3	-0.2	0.8	1.6	1.4
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.4	2.3	-0.4	-1.9	-1.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-0.9	0.1	1.0	1.5	1.3
Depression (Nagel 2018)	0.8	1.1	5.3	-2.3	-0.0	0.3	0.2	-0.5
Major Depression (MDD)	0.8	1.0	1.9	-0.1	0.7	0.9	1.4	1.3
HDL Cholesterol	0.8	1.4	2.1	0.0	-1.4	-1.4	-1.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	-0.7	1.3	0.3	1.4	0.6
Angina	0.8	1.0	3.3	-0.3	0.9	1.8	0.7	0.6
Townsend deprivation index at recruitment	0.8	1.2	2.7	-0.3	1.3	0.8	0.8	1.6
Medication: Levothyroxine sodium	0.8	1.4	2.0	-1.2	-1.2	-1.4	-0.5	-1.3
Trunk fat mass	0.8	3.6	15.5	3.9	-1.1	0.5	0.2	1.1
Time employed in main current job	0.8	1.0	2.9	-1.7	0.3	-0.1	1.2	0.7
Happiness	0.8	1.0	1.6	-0.9	0.3	1.3	1.0	1.3
Glaucoma (self-reported)	0.8	1.0	2.8	-0.3	-0.4	-0.3	-1.7	-1.3
Migraine (self-reported)	0.8	1.0	4.3	-2.1	0.5	0.3	0.7	0.1
Whole body fat mass	0.8	3.1	14.2	3.8	-0.8	0.5	-0.1	0.8
Family relationship satisfaction	0.8	1.0	2.8	-1.7	0.3	1.4	-0.1	-0.1
Knee pain experienced in last month	0.8	1.3	4.0	2.0	-1.1	0.1	0.6	0.9
Osteoporosis (self-reported)	0.8	1.0	2.0	-0.8	1.4	1.0	1.0	0.4
Guilty feelings	0.8	1.2	2.0	-0.6	1.1	1.4	1.2	1.0
Hearing aid user	0.8	0.9	2.1	1.2	-1.5	-0.7	-0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.7	-1.9	-0.7	0.1	-0.7	-0.8
Medication: Lisinopril	0.8	1.0	4.5	-2.1	0.4	0.4	0.4	0.3
Fractured/broken bones in last 5 years	0.8	1.1	2.6	-0.5	-0.2	-0.8	-1.6	-1.3
Neuroticism (Nagel 2018)	0.7	1.7	5.0	-2.2	1.2	1.3	0.4	0.5
Irritable Bowel Disease (IBD)	0.7	1.6	2.2	1.5	-1.5	-1.5	-1.1	-0.5
Fasting Glucose	0.7	0.8	2.0	1.2	-1.4	-0.7	0.1	0.2
Primary Biliary Cirrhosis	0.7	0.9	1.5	0.4	0.5	1.2	1.2	1.2
Ever had hysterectomy (womb removed)	0.7	0.7	1.6	-0.8	-0.7	-0.2	1.3	1.0
Average weekly fortified wine intake	0.7	0.8	2.1	0.9	-1.5	-0.6	-0.8	-0.4
Relative age voice broke	0.7	1.0	4.6	-2.1	-0.4	-0.3	0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.3	1.5	-0.4	-0.8	-0.8	0.1
Stomach or abdominal pain in last month	0.7	0.9	2.5	-0.2	0.0	-1.0	-1.0	-1.6
High blood pressure (mother)	0.7	1.0	2.7	-1.6	-0.9	-0.5	-1.1	-0.5
Weight	0.7	3.6	16.1	4.0	-0.8	0.5	0.4	0.9
Arm fat-free mass (right)	0.7	3.4	13.4	3.7	-0.2	0.4	1.5	1.2
Number of full brothers	0.7	0.9	3.4	1.8	-0.1	1.0	-0.5	-0.1
Eye problems/disorders: None of the above	0.7	0.9	1.9	-0.3	-1.1	-0.3	1.4	0.9
Number of full sisters	0.7	0.9	2.0	-1.2	-0.1	0.3	1.4	1.1
Back pain experienced in last month	0.7	1.0	3.1	-1.8	0.1	-0.1	-1.3	-0.5
Unable to work because of sickness or disability	0.7	0.8	2.3	-1.5	1.1	0.7	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	0.5	1.4	1.5	0.4	0.3
Waist Hip Ratio (WHR)	0.6	2.9	7.6	2.7	0.4	0.3	2.1	1.6
Respiratory disease	0.6	1.3	3.5	0.1	-0.2	-0.7	-1.6	-1.9
Chronotype (morning person)	0.6	1.3	3.1	1.1	-0.2	0.6	1.7	1.4
Pack years adult smoking proportion	0.6	0.9	2.0	-0.2	0.5	1.0	1.4	1.1
Impedance of leg (right)	0.6	2.9	13.4	3.7	-0.6	-0.8	-0.4	0.4
Trunk fat percentage	0.6	2.6	10.6	3.2	-1.0	0.5	0.0	1.1
Current tobacco smoking	0.6	0.9	2.2	-0.3	0.5	0.6	1.3	1.5
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.6	-1.4	-0.4	0.4	1.1
Heart attack	0.6	0.8	2.2	0.2	1.2	1.5	0.4	0.2
Falls in the last year	0.6	0.8	3.5	1.9	-0.2	-0.2	-0.3	-0.5
Length of working week for main job	0.6	0.6	2.5	1.6	-0.5	-0.6	0.0	0.0
Exposure to tobacco smoke at home	0.6	0.6	1.9	1.4	-0.3	-0.3	0.9	0.6
Hair/balding pattern: Pattern 4	0.6	1.4	3.1	0.7	0.2	0.3	1.8	1.8
Peak expiratory flow (PEF)	0.6	1.4	5.8	2.4	0.5	-1.0	-0.2	-0.2
Medication: Paracetamol	0.6	0.9	1.6	0.8	0.7	0.7	1.2	1.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.9	-2.0	-1.0	-0.8	0.7	-0.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.6	0.7	0.5	0.2	0.9	1.3
High blood pressure (siblings)	0.6	0.9	2.0	-1.4	-0.5	0.6	-0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.3	-1.8	0.4	-0.4	0.4	-0.4
Angina (self-reported)	0.6	0.8	2.7	-0.2	0.8	1.6	0.6	0.4
Leg fat mass (right)	0.6	2.3	10.1	3.2	-0.7	0.6	-0.4	0.6
Arm predicted mass (right)	0.6	3.2	14.0	3.7	-0.5	-0.0	1.1	0.8
Hypertension (Self-reported)	0.6	1.5	5.7	-2.4	0.3	1.1	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	-0.5	-0.6	-0.2	-1.7	-1.0
Medication: Gliclazide	0.6	0.7	1.3	-0.3	1.1	1.1	0.4	0.8
Wears glasses or contact lenses	0.6	0.7	3.3	-1.8	0.4	0.1	0.4	-0.1
Ever taken oral contraceptive pill	0.6	0.6	1.1	0.4	-1.1	-0.8	-0.9	-0.7
Arm fat-free mass (left)	0.6	3.3	13.1	3.6	-0.1	0.5	1.3	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	1.6	0.2	-0.8	-0.0	-0.4
Arm predicted mass (left)	0.6	3.3	14.6	3.8	-0.0	0.3	1.0	0.9
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	-1.3	1.5	0.9	0.8	0.6
Age at First Birth	0.5	0.7	1.8	-1.3	0.9	1.0	-0.2	0.1
Mean Putamen Volume	0.5	0.6	1.4	0.9	0.2	0.4	0.8	1.2
LDL Cholesterol	0.5	0.8	1.9	-0.6	1.4	1.4	-0.1	-0.2
Schizophrenia (2014)	0.5	1.0	4.1	-2.0	0.5	-0.0	0.8	-0.2
Triglycerides	0.5	0.7	1.8	-0.6	-0.7	-0.5	-0.9	-1.4
Ulcerative Colitis	0.5	0.7	2.2	1.5	-0.3	-1.0	0.1	0.4
High blood pressure	0.5	1.4	4.8	-2.2	-0.1	1.0	1.1	0.4
Impedance of leg (left)	0.5	2.6	11.0	3.3	-0.8	-0.9	-0.4	0.4
Waist circumference	0.5	2.0	7.7	2.8	-0.0	0.9	0.5	1.1
Number of incorrect matches in round	0.5	0.8	2.0	1.1	-0.1	-0.3	-1.4	-0.6
Nervous feelings	0.5	1.0	3.7	-1.9	0.1	0.6	0.7	0.6
Medication: Ramipril	0.5	0.7	2.4	1.5	-0.7	-0.4	0.5	-0.0
Trunk fat-free mass	0.5	2.9	11.8	3.4	-0.3	0.2	1.4	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.3	1.0	0.5	0.8	0.8
Trunk predicted mass	0.5	2.8	11.5	3.4	-0.4	0.1	1.3	0.8
Headache pain in last month	0.5	0.8	2.4	-1.6	1.2	-0.0	-0.1	-0.1
Medication: Amlodipine	0.5	0.7	2.9	-1.7	-0.1	0.6	-0.1	-0.5
Body fat percentage	0.5	2.0	8.4	2.9	-1.0	0.3	-0.5	0.5
Exposure to tobacco smoke outside home	0.5	0.7	1.4	0.1	1.2	1.0	0.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.6	-0.4	1.3	0.7	0.5	0.4
Qualifications: College or University degree	0.5	1.5	4.0	0.6	-0.6	-0.9	-2.0	-1.4
Medication: Seretide 50 evohaler	0.5	0.6	1.5	1.2	0.1	-1.1	0.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.3	-1.0	0.7	1.1	-0.5	-0.5
Pulse rate, automated reading	0.5	1.6	7.3	-2.7	-0.6	-0.4	0.3	0.1
Chest pain or discomfort	0.5	0.8	2.9	-0.6	1.7	0.5	0.5	0.4
Whole body fat-free mass	0.5	2.7	11.1	3.3	-0.4	0.2	1.1	0.9
Mood swings	0.5	0.8	3.2	-1.8	0.2	0.0	-0.7	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.9	-0.4	-1.4	-0.6	-0.2	-0.6
Smoking status: Current	0.5	0.8	2.1	-0.1	0.1	0.2	1.5	1.4
Whole body water mass	0.5	2.6	11.2	3.3	-0.5	0.1	1.0	0.7
Arm fat mass (left)	0.5	2.0	8.4	2.9	-1.0	0.4	-0.6	0.2
Number of self-reported non-cancer illnesses	0.5	0.9	3.0	-1.7	0.2	0.2	-0.5	-1.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	-0.0	-0.0	-0.5	-1.3	-1.0
Medication: Blood pressure	0.5	0.9	2.3	-0.1	0.6	0.3	-1.3	-1.5
Basal metabolic rate	0.5	3.0	13.0	3.6	-0.5	0.3	1.0	0.9
Heart disease (siblings)	0.5	0.6	1.4	1.2	-0.3	-0.1	-1.0	-0.9
Leg fat mass (left)	0.5	2.1	9.0	3.0	-0.7	0.7	-0.0	0.8
Bipolar Disorder (2018)	0.4	0.7	1.1	-0.6	0.8	0.8	0.8	1.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-1.6	0.4	0.7	0.6	0.7
Number of treatments/medications taken	0.4	0.6	2.3	-1.5	0.6	0.6	0.3	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	1.3	0.6	0.0	0.1	0.5
Diabetes (mother)	0.4	0.5	1.5	0.5	-0.5	1.2	-0.3	0.5
Leg fat-free mass (left)	0.4	2.0	8.3	2.9	-0.5	0.4	0.7	0.8
Fed-up feelings	0.4	0.7	1.5	1.2	0.2	0.3	0.9	1.1
Sitting height	0.4	2.9	5.0	1.1	0.3	2.1	1.9	2.2
Leg predicted mass (left)	0.4	2.0	8.3	2.9	-0.4	0.4	0.9	0.9
Forced vital capacity (FVC)	0.4	1.7	5.4	0.6	0.7	0.3	2.3	1.5
Impedance of arm (left)	0.4	1.6	5.3	2.3	-1.2	-1.0	-0.6	-0.1
Arm fat mass (right)	0.4	1.7	7.1	2.7	-0.8	0.4	-0.5	0.3
Forced vital capacity (FVC), Best measure	0.4	1.3	4.2	-0.3	0.9	0.2	2.0	1.2
Leg fat percentage (right)	0.4	1.4	5.4	2.3	-0.7	0.4	-0.9	0.3
Medication: Omeprazole	0.4	0.5	1.1	-0.1	0.2	0.6	1.0	1.0
Suffer from ‘nerves’	0.4	0.7	2.8	-1.7	-0.4	-0.6	-0.2	-0.4
Leg pain on walking	0.4	0.5	2.1	1.5	-0.4	0.0	0.2	0.3
Illnesses of father: Heart disease	0.4	0.5	1.7	0.1	0.4	0.2	1.3	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.4	1.1	1.2	0.5	-0.2
Qualifications: nursing, teaching	0.4	0.7	1.3	-0.8	1.1	1.0	0.6	0.4
Medication for cholesterol	0.4	0.7	1.4	-0.4	-0.4	-0.7	1.1	1.2
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.9	-0.9	0.3	0.6	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	-1.1	0.7	0.5	-0.5	-0.4
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.2	0.5	1.4	0.6	0.5
Illnesses of father: High blood pressure	0.4	0.5	1.6	-1.3	-0.6	0.2	0.6	0.1
Number of operations (self-reported)	0.4	0.6	1.6	0.4	0.7	1.3	0.7	0.7
Average weekly beer plus cider intake	0.4	0.6	1.9	0.1	0.6	0.6	0.5	1.4
Irritability	0.4	0.7	1.4	0.7	1.2	0.8	0.6	0.7
Age started oral contraceptive pill	0.4	0.5	1.9	1.4	0.4	0.1	0.1	0.7
Impedance of whole body	0.4	1.8	7.0	2.6	-1.1	-0.8	-0.2	0.4
Schizophrenia (2018)	0.3	0.7	1.6	-1.2	1.3	0.6	0.3	-0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.8	-0.7	-0.3	-0.4	-0.2
Prostate Cancer	0.3	0.4	0.8	0.7	0.8	0.2	0.2	0.9
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.4	-0.6	-0.1	-0.5	0.8
Coronary Artery Disease (CAD)	0.3	0.3	1.4	-1.2	0.0	0.4	-0.2	-0.1
HbA1C	0.3	0.4	0.9	-0.7	0.9	0.4	-0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	1.0	-0.3	0.3	0.5	0.4
Neuroticism	0.3	0.8	1.6	-1.1	0.8	1.3	0.1	0.7
Hair Pigment	0.3	9.9	21.7	1.6	-3.5	-4.7	-2.5	-2.6
Tanning	0.3	3.5	6.3	1.8	-0.8	-1.7	-2.0	-2.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	-1.1	0.4	-0.6	-0.1	-0.7
Relative age of first facial hair	0.3	0.7	1.6	-1.3	0.6	0.5	1.0	0.4
Vitamin and mineral supplements	0.3	0.4	1.0	1.0	-0.1	-0.5	0.3	-0.6
Diabetes (father)	0.3	0.4	0.6	0.8	-0.4	0.5	-0.7	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-1.0	0.2	0.2	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-1.2	-1.1	-0.0	-0.4	-0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.3	-0.7	-0.1	-0.6	-1.1
Multivitamins +/- minerals	0.3	0.4	1.0	0.1	-1.0	-0.2	-1.0	-0.0
Past tobacco smoking	0.3	0.6	1.4	-1.2	0.1	0.5	1.0	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.8	-0.1	-0.4	0.9	0.7
Had other major operations	0.3	0.4	0.9	-0.7	0.1	0.5	1.0	0.7
Qualifications: None of the above	0.3	0.7	2.2	0.5	-1.5	-0.9	-0.5	-0.2
Pain all over the body in last month	0.3	0.3	0.5	-0.5	0.7	0.7	0.5	-0.1
Impedance of arm (right)	0.3	1.3	3.8	2.0	-0.9	-0.9	-1.0	-0.3
Arm fat percentage (right)	0.3	1.1	2.8	1.7	-1.1	0.1	-1.1	-0.1
Hip circumference	0.3	1.5	5.7	2.4	-0.9	-0.2	-0.9	-0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.4	0.7	0.9	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.2	0.9	0.6	-0.0	1.8	1.1
Gout (self-reported)	0.3	0.4	0.9	-0.9	0.7	-0.1	-0.2	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.0	0.9	0.1	1.0	0.3
Worry too long after embarrassment	0.3	0.5	1.3	-1.1	0.6	0.8	-0.2	-0.2
Health satisfaction	0.3	0.5	1.9	-0.3	-1.4	-0.3	0.3	0.3
Alcohol intake frequency.	0.3	0.6	2.8	-1.7	-0.0	-0.6	-0.3	0.0
Supplements: Vitamin C	0.3	0.3	0.6	-0.8	0.5	0.2	0.6	0.7
Leg fat-free mass (right)	0.3	1.6	6.0	2.5	-0.5	0.2	1.0	0.8
Arm fat percentage (left)	0.3	1.2	3.7	1.9	-1.3	0.1	-1.0	-0.1
Loneliness, isolation	0.3	0.4	0.7	-0.8	0.7	0.7	0.2	0.5
Ever had bowel cancer screening	0.3	0.4	0.9	-0.0	0.5	0.1	-0.7	-1.0
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.1	0.9	0.7	-0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	-0.5	0.5	1.1	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	1.2	0.0	-0.5	-0.5	-0.1
Leg predicted mass (right)	0.3	1.7	6.3	2.5	-0.5	0.3	1.1	0.9
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.3	0.3	0.8	0.4	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	-0.8	-0.1	0.3	0.8	0.6
Ever smoked	0.3	0.4	1.0	1.0	-0.2	-0.2	-0.8	-0.7
Leg fat percentage (left)	0.3	1.0	4.1	2.0	-0.6	0.4	-0.4	0.6
Pain experienced in last month	0.3	0.5	1.1	1.1	-1.0	-0.7	0.0	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	0.2	1.5	0.6	-0.1	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.8	0.6	0.4	0.3	0.0
Crohns Disease (2017)	0.2	0.4	0.9	0.4	-1.0	-0.3	-0.2	0.9
Lupus	0.2	0.2	0.6	0.2	0.1	0.0	0.8	0.7
Blood Eosinophil Count	0.2	1.6	7.8	2.8	-0.0	-0.3	0.1	0.3
Blood Platelet Count	0.2	2.4	6.7	-2.6	-1.4	-1.1	-0.5	-1.4
Heel T-Score	0.2	1.8	3.8	-1.7	-0.7	-1.0	-1.0	-1.9
Systolic Blood Pressure	0.2	0.9	2.8	-0.1	-1.7	0.7	0.5	0.9
Allergy or Eczema	0.2	0.6	1.7	-1.3	0.9	0.4	0.2	0.3
Systolic blood pressure, automated reading	0.2	0.7	1.3	-0.2	-0.9	0.7	0.9	1.1
Medication: Co-codamol	0.2	0.2	0.5	-0.7	0.6	0.4	0.3	0.2
Severe depression (siblings)	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.5	0.0
Taking other prescription medications	0.2	0.3	0.5	-0.5	-0.7	-0.7	-0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	-0.7	-1.0	-0.5	-0.5	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.6	0.8	-0.3	-0.4	0.1
Fluid intelligence score	0.2	0.4	0.8	-0.1	0.5	-0.6	-0.7	-0.9
Illnesses of siblings	0.2	0.3	0.9	0.9	0.3	-0.5	0.2	0.6
Number of live births	0.2	0.3	0.5	0.7	-0.6	-0.6	0.3	-0.1
Pulse rate	0.2	0.3	1.0	-1.0	-0.5	-0.3	0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.3	0.2	-0.3	-1.0	-1.0
Medication: Lansoprazole	0.2	0.3	0.7	-0.4	0.7	0.8	-0.1	-0.2
Lung cancer (father)	0.2	0.3	0.7	-0.2	0.1	0.4	-0.8	-0.7
Loud music exposure frequency	0.2	0.2	0.8	0.1	0.9	0.1	0.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.5	-0.5	-0.7	-0.5	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	-1.0	0.6	0.3	0.3	0.3
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.4	-0.7	0.3	-0.1	-0.5
Birth weight	0.2	0.5	2.0	1.4	0.4	-0.2	0.5	-0.3
Medication: Allopurinol	0.2	0.3	0.7	-0.4	0.1	0.3	-0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.8	0.2	0.3	-0.0	0.2
Smoking status: Previous	0.2	0.3	0.7	0.3	0.6	0.6	-0.8	-0.3
Average weekly red wine intake	0.2	0.4	1.3	0.3	-0.1	-0.5	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	-1.0	0.7	-0.3	-0.4	-0.1
Miserableness	0.2	0.4	0.6	0.2	0.6	0.8	0.7	0.6
Mother’s age at death	0.2	0.2	0.7	-0.2	0.8	-0.6	-0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.2	-0.8	-0.1	-0.5	-0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.3	0.0	-0.3	0.0	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	1.0	0.5	-0.2	0.3	0.4
Breast Cancer	0.1	0.2	0.5	-0.0	0.5	0.3	0.2	0.7
Neuroticism (2016)	0.1	0.1	0.2	-0.3	-0.5	-0.1	-0.1	0.5
Blood Red Count	0.1	1.3	3.4	-1.9	0.3	0.4	1.5	0.8
Blood White Count	0.1	0.4	1.0	-1.0	0.0	0.5	0.4	0.8
BMI	0.1	0.4	0.9	0.6	-1.0	-0.0	-0.7	-0.1
Smoking Status	0.1	0.2	0.6	0.3	0.8	0.2	0.5	0.5
Average weekly spirits intake	0.1	0.2	0.4	-0.5	0.7	-0.1	-0.3	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.0	0.3	0.3	-0.4	0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.2	-0.2	-0.2	0.7	-0.3
Hand grip strength (right)	0.1	0.3	1.2	-0.2	-1.1	-0.4	-0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.6	-0.2	0.3	0.2	0.1
Age when periods started (menarche)	0.1	0.2	0.4	0.2	-0.4	-0.5	-0.3	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.2	0.3	-0.6	-0.4	-0.4
Body mass index (BMI)	0.1	0.2	0.6	0.6	-0.2	0.8	-0.5	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.5	-0.3	0.2	0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.3	0.3
Allergy	0.1	0.2	0.3	-0.6	-0.6	0.0	0.2	0.4
Neuroticism score	0.1	0.1	0.3	-0.4	0.4	0.5	-0.1	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.2	0.5	0.4	-0.1	0.3
Asthma	0.1	0.3	1.1	1.0	0.2	0.3	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.0	0.2	0.5	-0.4	1.0	0.4
Tense / ‘highly strung’	0.1	0.2	0.5	-0.3	0.7	0.3	0.4	-0.3
Birth weight of first child	0.1	0.1	0.3	0.2	-0.4	-0.3	0.4	0.5
Number of children fathered	0.1	0.1	0.3	-0.2	-0.3	0.3	0.6	0.2
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.7	0.4	0.1	-0.5	-0.3
Overall health rating	0.1	0.2	0.5	-0.7	-0.1	0.7	-0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.0	-0.7	0.1	-0.4	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.5	-0.1
Asthma (self-reported)	0.1	0.2	0.8	0.9	0.3	0.2	-0.1	0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.6	0.0	0.3	-0.2	-0.4
Medication: Paracetamol	0.1	0.2	0.6	0.8	0.4	0.1	-0.0	-0.1
Ever depressed for a whole week	0.1	0.1	0.4	-0.2	0.1	0.2	0.3	0.7
Cholesterol lowering medication	0.1	0.2	0.3	-0.1	0.3	0.5	0.5	-0.4
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.3	0.2	0.1	0.2	0.3
Hand grip strength (left)	0.0	0.1	0.3	-0.5	-0.4	-0.3	-0.2	0.3
Myopia	0.0	0.0	0.1	0.2	0.3	0.0	0.2	0.1

Hub : Genes

CEP152

Models

Trait associations