Hub : Genes

CEP152

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0490 0.0250 2.4e-03 0.005 0.011 0.012 0.013 0.008 0.06700 0.016 1.1e-02 0.0096 2.9e-02
2 GTEx Cells EBV-transformed lymphocytes 0.3860 0.0900 7.1e-05 0.102 NA 0.167 NA 0.131 0.00032 NA 4.0e-06 NA 5.0e-05
3 GTEx Esophagus Mucosa 0.2140 0.0830 2.0e-03 0.051 NA 0.035 NA 0.029 0.00026 NA 2.0e-03 NA 5.0e-03
4 GTEx Nerve Tibial 0.1338 0.0490 2.9e-04 0.047 NA 0.030 NA 0.055 0.00027 NA 3.4e-03 NA 9.3e-05
5 TCGA Brain Lower Grade Glioma 0.0462 0.0248 3.1e-04 0.011 0.023 0.031 NA 0.022 0.01700 0.001 1.6e-04 NA 1.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.7 1.1 -0.6 0.8 0.8 0.8 1.1
Bipolar Disorder or Schizophrenia 0.5 1.1 2.1 -1.3 1.5 0.9 0.8 0.6
Depressed Affect (Nagel 2018) 0.4 0.8 2.6 -1.6 0.4 0.7 0.6 0.7
Depression (Nagel 2018) 0.8 1.1 5.3 -2.3 -0.0 0.3 0.2 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.3 0.2 1.5 0.6 -0.1 -0.3
Neuroticism (Nagel 2018) 0.7 1.7 5.0 -2.2 1.2 1.3 0.4 0.5
Schizophrenia (2018) 0.3 0.7 1.6 -1.2 1.3 0.6 0.3 -0.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.3 0.0 -0.3 0.0 -0.5
Worry (Nagel 2018) 1.0 2.2 9.1 -3.0 0.6 1.1 0.1 0.3
Alzheimer’s Disease (in mother) 0.2 0.3 0.7 -0.8 0.6 0.4 0.3 0.0
Alzheimer’s Disease (in father) 0.3 0.3 0.7 -0.8 -0.7 -0.3 -0.4 -0.2
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 -0.3 0.2 0.1 0.2 0.3
Crohns Disease (2017) 0.2 0.4 0.9 0.4 -1.0 -0.3 -0.2 0.9
Irritable Bowel Disease (IBD) 0.7 1.6 2.2 1.5 -1.5 -1.5 -1.1 -0.5
Ulcerative Colitis (UC) 1.4 2.7 4.1 1.9 -1.4 -2.0 -1.3 -1.4
Major Depression (MDD) 0.8 1.0 1.9 -0.1 0.7 0.9 1.4 1.3
Reaction Time 2.6 5.0 12.0 -0.4 1.1 1.5 3.0 3.5
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.9 1.0 0.5 -0.2 0.3 0.4
Breast Cancer 0.1 0.2 0.5 -0.0 0.5 0.3 0.2 0.7
Ovarian Cancer 1.1 1.4 3.0 -0.3 -0.5 -1.5 -1.2 -1.7
Prostate Cancer 0.3 0.4 0.8 0.7 0.8 0.2 0.2 0.9
Age at First Birth 0.5 0.7 1.8 -1.3 0.9 1.0 -0.2 0.1
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.4 -0.6 -0.1 -0.5 0.8
Body Mass Index (BMI) (2010) 1.7 2.4 6.8 -0.3 2.6 1.9 0.7 1.0
Coronary Artery Disease (CAD) 0.3 0.3 1.4 -1.2 0.0 0.4 -0.2 -0.1
Crohns Disease (2012) 2.0 3.3 7.5 -0.5 0.8 1.5 2.4 2.7
Mean Putamen Volume 0.5 0.6 1.4 0.9 0.2 0.4 0.8 1.2
Fasting Glucose 0.7 0.8 2.0 1.2 -1.4 -0.7 0.1 0.2
HbA1C 0.3 0.4 0.9 -0.7 0.9 0.4 -0.4 -0.4
HDL Cholesterol 0.8 1.4 2.1 0.0 -1.4 -1.4 -1.3 -1.0
LDL Cholesterol 0.5 0.8 1.9 -0.6 1.4 1.4 -0.1 -0.2
Lupus 0.2 0.2 0.6 0.2 0.1 0.0 0.8 0.7
Neuroticism (2016) 0.1 0.1 0.2 -0.3 -0.5 -0.1 -0.1 0.5
Primary Biliary Cirrhosis 0.7 0.9 1.5 0.4 0.5 1.2 1.2 1.2
Rheumatoid Arthritis 1.6 2.2 3.4 -1.5 -1.4 -0.7 -1.9 -1.7
Schizophrenia (2014) 0.5 1.0 4.1 -2.0 0.5 -0.0 0.8 -0.2
Triglycerides 0.5 0.7 1.8 -0.6 -0.7 -0.5 -0.9 -1.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.0 1.0 -0.3 0.3 0.5 0.4
Ulcerative Colitis 0.5 0.7 2.2 1.5 -0.3 -1.0 0.1 0.4
Blood Eosinophil Count 0.2 1.6 7.8 2.8 -0.0 -0.3 0.1 0.3
Blood Platelet Count 0.2 2.4 6.7 -2.6 -1.4 -1.1 -0.5 -1.4
Blood Red Count 0.1 1.3 3.4 -1.9 0.3 0.4 1.5 0.8
Blood White Count 0.1 0.4 1.0 -1.0 0.0 0.5 0.4 0.8
Heel T-Score 0.2 1.8 3.8 -1.7 -0.7 -1.0 -1.0 -1.9
BMI 0.1 0.4 0.9 0.6 -1.0 -0.0 -0.7 -0.1
Height 1.4 26.6 118.8 10.9 -2.4 -1.6 1.9 1.4
Waist Hip Ratio (WHR) 0.6 2.9 7.6 2.7 0.4 0.3 2.1 1.6
Systolic Blood Pressure 0.2 0.9 2.8 -0.1 -1.7 0.7 0.5 0.9
Smoking Status 0.1 0.2 0.6 0.3 0.8 0.2 0.5 0.5
Allergy or Eczema 0.2 0.6 1.7 -1.3 0.9 0.4 0.2 0.3
Cardiovascular Disease 0.9 3.1 5.4 -2.2 1.2 2.3 1.5 1.3
Hypothyroidism (self reported) 1.2 2.8 3.8 -1.7 -1.9 -1.9 -0.9 -1.8
Respiratory disease 0.6 1.3 3.5 0.1 -0.2 -0.7 -1.6 -1.9
Type 2 Diabetes (T2D) (2018) 1.3 2.4 2.9 -1.4 1.7 1.4 1.5 1.7
Lung FEV1/FVC ratio 1.0 4.9 9.0 3.0 -2.0 -3.0 -1.4 -0.9
Lung FVC 1.1 5.8 15.7 -4.0 1.8 1.3 2.2 2.0
Neuroticism 0.3 0.8 1.6 -1.1 0.8 1.3 0.1 0.7
Chronotype (morning person) 0.6 1.3 3.1 1.1 -0.2 0.6 1.7 1.4
Hair Pigment 0.3 9.9 21.7 1.6 -3.5 -4.7 -2.5 -2.6
Tanning 0.3 3.5 6.3 1.8 -0.8 -1.7 -2.0 -2.5
Hand grip strength (left) 0.0 0.1 0.3 -0.5 -0.4 -0.3 -0.2 0.3
Number of treatments/medications taken 0.4 0.6 2.3 -1.5 0.6 0.6 0.3 -0.1
Average weekly spirits intake 0.1 0.2 0.4 -0.5 0.7 -0.1 -0.3 -0.2
Sensitivity / hurt feelings 0.1 0.1 0.2 -0.0 0.3 0.3 -0.4 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 -1.1 0.4 -0.6 -0.1 -0.7
Hearing difficulty/problems: Yes 0.1 0.1 0.5 0.2 -0.2 -0.2 0.7 -0.3
Relative age of first facial hair 0.3 0.7 1.6 -1.3 0.6 0.5 1.0 0.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 3.0 0.0 -1.2 -1.2 -1.1 -1.7
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.8 1.3 0.6 0.0 0.1 0.5
Ever had hysterectomy (womb removed) 0.7 0.7 1.6 -0.8 -0.7 -0.2 1.3 1.0
Systolic blood pressure, automated reading 0.2 0.7 1.3 -0.2 -0.9 0.7 0.9 1.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.0 -0.7 1.3 0.3 1.4 0.6
Angina 0.8 1.0 3.3 -0.3 0.9 1.8 0.7 0.6
Medication for hormone replacement therapy 1.0 1.1 2.4 1.2 -0.3 0.7 -1.5 -1.0
Vitamin and mineral supplements 0.3 0.4 1.0 1.0 -0.1 -0.5 0.3 -0.6
Supplements: Zinc 1.1 1.2 1.4 -1.1 1.0 1.2 1.0 1.2
Medication: Co-codamol 0.2 0.2 0.5 -0.7 0.6 0.4 0.3 0.2
Medication: Metformin 0.9 1.3 2.3 -1.4 0.7 0.5 1.2 1.5
Diabetes (father) 0.3 0.4 0.6 0.8 -0.4 0.5 -0.7 -0.5
Diabetes (mother) 0.4 0.5 1.5 0.5 -0.5 1.2 -0.3 0.5
Severe depression (siblings) 0.2 0.2 0.4 -0.5 -0.4 -0.6 -0.5 0.0
Pack years adult smoking proportion 0.6 0.9 2.0 -0.2 0.5 1.0 1.4 1.1
Impedance of leg (right) 0.6 2.9 13.4 3.7 -0.6 -0.8 -0.4 0.4
Leg fat-free mass (left) 0.4 2.0 8.3 2.9 -0.5 0.4 0.7 0.8
Trunk fat percentage 0.6 2.6 10.6 3.2 -1.0 0.5 0.0 1.1
Hand grip strength (right) 0.1 0.3 1.2 -0.2 -1.1 -0.4 -0.2 -0.1
Townsend deprivation index at recruitment 0.8 1.2 2.7 -0.3 1.3 0.8 0.8 1.6
Current tobacco smoking 0.6 0.9 2.2 -0.3 0.5 0.6 1.3 1.5
Average weekly fortified wine intake 0.7 0.8 2.1 0.9 -1.5 -0.6 -0.8 -0.4
Maternal smoking around birth 1.7 2.5 3.9 -0.7 -2.0 -1.2 -1.7 -1.8
Fed-up feelings 0.4 0.7 1.5 1.2 0.2 0.3 0.9 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 -0.6 -0.2 0.3 0.2 0.1
Relative age voice broke 0.7 1.0 4.6 -2.1 -0.4 -0.3 0.5 -0.3
Taking other prescription medications 0.2 0.3 0.5 -0.5 -0.7 -0.7 -0.0 -0.6
Age when periods started (menarche) 0.1 0.2 0.4 0.2 -0.4 -0.5 -0.3 0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.0 -1.0 0.2 0.2 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.4 -1.2 -1.1 -0.0 -0.4 -0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 2.3 1.5 -0.4 -0.8 -0.8 0.1
Qualifications: CSEs or equivalent 0.6 0.8 2.0 0.6 -1.4 -0.4 0.4 1.1
Serious illness, injury or assault to yourself 0.3 0.4 1.1 0.3 -0.7 -0.1 -0.6 -1.1
High blood pressure 0.5 1.4 4.8 -2.2 -0.1 1.0 1.1 0.4
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 0.2 0.3 -0.6 -0.4 -0.4
Multivitamins +/- minerals 0.3 0.4 1.0 0.1 -1.0 -0.2 -1.0 -0.0
Stomach or abdominal pain in last month 0.7 0.9 2.5 -0.2 0.0 -1.0 -1.0 -1.6
Supplements: Glucosamine 1.0 1.3 2.8 -0.7 -1.1 -1.2 -0.6 -1.7
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.0 2.0 -0.5 0.0 -1.8 -1.6
Medication: Atenolol 1.0 1.2 3.7 -0.3 1.3 1.9 0.1 0.7
Medication: Levothyroxine sodium 0.8 1.4 2.0 -1.2 -1.2 -1.4 -0.5 -1.3
Sitting height 0.4 2.9 5.0 1.1 0.3 2.1 1.9 2.2
Chronic bronchitis/emphysema (father) 1.3 1.5 3.6 -0.5 1.9 1.9 0.1 -0.2
High blood pressure (mother) 0.7 1.0 2.7 -1.6 -0.9 -0.5 -1.1 -0.5
Body mass index (BMI) 0.1 0.2 0.6 0.6 -0.2 0.8 -0.5 0.1
Impedance of leg (left) 0.5 2.6 11.0 3.3 -0.8 -0.9 -0.4 0.4
Leg predicted mass (left) 0.4 2.0 8.3 2.9 -0.4 0.4 0.9 0.9
Trunk fat mass 0.8 3.6 15.5 3.9 -1.1 0.5 0.2 1.1
Waist circumference 0.5 2.0 7.7 2.8 -0.0 0.9 0.5 1.1
Number of incorrect matches in round 0.5 0.8 2.0 1.1 -0.1 -0.3 -1.4 -0.6
Past tobacco smoking 0.3 0.6 1.4 -1.2 0.1 0.5 1.0 0.7
Alcohol usually taken with meals 1.1 1.9 3.3 1.3 -0.6 -1.8 -0.9 -1.8
Nervous feelings 0.5 1.0 3.7 -1.9 0.1 0.6 0.7 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.5 -0.4 -1.2 -1.2 -1.6 -1.5
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.5 -0.3 0.2 0.1 -0.3
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 -0.8 -0.1 -0.4 0.9 0.7
Had menopause 1.6 2.0 3.2 0.4 1.1 1.6 1.8 1.8
Had other major operations 0.3 0.4 0.9 -0.7 0.1 0.5 1.0 0.7
Forced vital capacity (FVC) 0.4 1.7 5.4 0.6 0.7 0.3 2.3 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.9 -0.7 -1.0 -0.5 -0.5 -0.7
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.4 -0.3 -0.4 0.3 0.3
Qualifications: None of the above 0.3 0.7 2.2 0.5 -1.5 -0.9 -0.5 -0.2
Financial difficulties in last 2 years 1.3 1.8 3.2 0.8 -0.9 -1.1 -1.8 -1.7
Mouth/teeth dental problems 0.9 1.3 3.5 1.9 -0.2 -0.5 -1.1 -1.3
Heart attack 0.6 0.8 2.2 0.2 1.2 1.5 0.4 0.2
Allergy 0.1 0.2 0.3 -0.6 -0.6 0.0 0.2 0.4
Pain all over the body in last month 0.3 0.3 0.5 -0.5 0.7 0.7 0.5 -0.1
Diabetes (self-reported) 2.2 3.4 5.8 -1.4 2.4 2.1 1.6 1.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.6 0.8 -0.3 -0.4 0.1
Medication: Ramipril 0.5 0.7 2.4 1.5 -0.7 -0.4 0.5 -0.0
Medication: Simvastatin 1.5 2.1 7.0 -2.6 0.3 0.8 1.6 0.5
Fluid intelligence score 0.2 0.4 0.8 -0.1 0.5 -0.6 -0.7 -0.9
Illnesses of siblings 0.2 0.3 0.9 0.9 0.3 -0.5 0.2 0.6
Neuroticism score 0.1 0.1 0.3 -0.4 0.4 0.5 -0.1 0.1
Weight 0.7 3.6 16.1 4.0 -0.8 0.5 0.4 0.9
Impedance of arm (right) 0.3 1.3 3.8 2.0 -0.9 -0.9 -1.0 -0.3
Arm fat percentage (right) 0.3 1.1 2.8 1.7 -1.1 0.1 -1.1 -0.1
Trunk fat-free mass 0.5 2.9 11.8 3.4 -0.3 0.2 1.4 0.9
Hip circumference 0.3 1.5 5.7 2.4 -0.9 -0.2 -0.9 -0.2
Time employed in main current job 0.8 1.0 2.9 -1.7 0.3 -0.1 1.2 0.7
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.2 0.5 0.4 -0.1 0.3
Father’s age at death 2.6 3.5 6.7 1.0 -1.6 -2.0 -1.8 -2.6
Worrier / anxious feelings 1.5 2.8 5.6 -2.4 1.4 1.5 1.3 1.6
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 2.5 -0.1 1.6 1.1 1.5 1.4
Falls in the last year 0.6 0.8 3.5 1.9 -0.2 -0.2 -0.3 -0.5
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 -0.4 0.7 0.9 -0.6 -0.6
Number of live births 0.2 0.3 0.5 0.7 -0.6 -0.6 0.3 -0.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 3.2 0.9 0.6 -0.0 1.8 1.1
Pulse rate 0.2 0.3 1.0 -1.0 -0.5 -0.3 0.0 -0.2
Happiness 0.8 1.0 1.6 -0.9 0.3 1.3 1.0 1.3
Noisy workplace 2.5 3.0 8.5 -2.9 -1.7 -1.5 -0.4 -1.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 0.3 0.2 -0.3 -1.0 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.1 0.3 1.0 0.5 0.8 0.8
Mouth/teeth dental problems: Dentures 1.3 2.2 4.8 -1.3 -0.3 0.6 2.2 2.0
Asthma 0.1 0.3 1.1 1.0 0.2 0.3 -0.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 5.3 2.3 -0.1 -0.7 0.8 0.9
Medication: Cholesterol lowering 2.6 4.0 5.7 -2.4 1.8 2.2 1.8 1.8
Depression (self-reported) 1.3 1.5 2.7 -1.6 -0.5 -0.9 -1.6 -1.1
Medication: Lansoprazole 0.2 0.3 0.7 -0.4 0.7 0.8 -0.1 -0.2
Prospective memory result 1.5 1.9 3.4 -1.8 1.1 1.7 1.2 0.8
Lung cancer (father) 0.2 0.3 0.7 -0.2 0.1 0.4 -0.8 -0.7
Illnesses of mother 0.9 1.1 4.9 2.2 0.5 0.3 0.3 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.0 0.2 0.5 -0.4 1.0 0.4
Pulse wave Arterial Stiffness index 1.2 1.4 3.1 -0.5 1.0 1.8 0.9 1.4
Impedance of arm (left) 0.4 1.6 5.3 2.3 -1.2 -1.0 -0.6 -0.1
Arm fat mass (right) 0.4 1.7 7.1 2.7 -0.8 0.4 -0.5 0.3
Trunk predicted mass 0.5 2.8 11.5 3.4 -0.4 0.1 1.3 0.8
Standing height 1.4 13.6 59.6 7.7 -1.5 -0.8 1.8 1.6
Length of working week for main job 0.6 0.6 2.5 1.6 -0.5 -0.6 0.0 0.0
Exposure to tobacco smoke at home 0.6 0.6 1.9 1.4 -0.3 -0.3 0.9 0.6
Breastfed as a baby 2.2 2.7 6.7 -0.1 -1.1 -1.4 -1.9 -2.6
Tense / ‘highly strung’ 0.1 0.2 0.5 -0.3 0.7 0.3 0.4 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.4 -1.8 1.2 0.3 1.6 0.4
Hair/balding pattern: Pattern 4 0.6 1.4 3.1 0.7 0.2 0.3 1.8 1.8
Birth weight of first child 0.1 0.1 0.3 0.2 -0.4 -0.3 0.4 0.5
Peak expiratory flow (PEF) 0.6 1.4 5.8 2.4 0.5 -1.0 -0.2 -0.2
Pulse wave reflection index 1.4 1.8 4.0 -2.0 1.4 1.4 0.4 0.9
Ever highly irritable/argumentative for 2 days 0.9 1.0 3.3 1.8 -1.1 -0.7 -0.0 -0.0
Loud music exposure frequency 0.2 0.2 0.8 0.1 0.9 0.1 0.5 0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.4 -0.5 -0.5 -0.7 -0.5 -0.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.0 -1.0 0.6 0.3 0.3 0.3
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.4 -0.7 0.3 -0.1 -0.5
Medication: Paracetamol 0.6 0.9 1.6 0.8 0.7 0.7 1.2 1.3
Headache pain in last month 0.5 0.8 2.4 -1.6 1.2 -0.0 -0.1 -0.1
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 7.5 2.7 -1.1 -1.6 -1.8 -1.6
Glaucoma (self-reported) 0.8 1.0 2.8 -0.3 -0.4 -0.3 -1.7 -1.3
Gout (self-reported) 0.3 0.4 0.9 -0.9 0.7 -0.1 -0.2 -0.8
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.9 -2.0 -1.0 -0.8 0.7 -0.3
Medication: Amlodipine 0.5 0.7 2.9 -1.7 -0.1 0.6 -0.1 -0.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.0 0.9 0.1 1.0 0.3
Birth weight 0.2 0.5 2.0 1.4 0.4 -0.2 0.5 -0.3
Chronic bronchitis/emphysema (mother) 0.6 0.6 1.6 0.7 0.5 0.2 0.9 1.3
High blood pressure (siblings) 0.6 0.9 2.0 -1.4 -0.5 0.6 -0.9 -1.0
Forced vital capacity (FVC), Best measure 0.4 1.3 4.2 -0.3 0.9 0.2 2.0 1.2
Body fat percentage 0.5 2.0 8.4 2.9 -1.0 0.3 -0.5 0.5
Leg fat percentage (right) 0.4 1.4 5.4 2.3 -0.7 0.4 -0.9 0.3
Arm fat-free mass (right) 0.7 3.4 13.4 3.7 -0.2 0.4 1.5 1.2
Exposure to tobacco smoke outside home 0.5 0.7 1.4 0.1 1.2 1.0 0.2 0.9
Comparative body size at age 10 2.5 7.0 12.0 1.8 -1.5 -2.4 -3.5 -3.4
Number of full brothers 0.7 0.9 3.4 1.8 -0.1 1.0 -0.5 -0.1
Worry too long after embarrassment 0.3 0.5 1.3 -1.1 0.6 0.8 -0.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.3 -1.8 0.4 -0.4 0.4 -0.4
Wheeze or whistling in the chest in last year 1.4 2.6 4.2 -1.4 1.0 2.0 1.3 2.0
Number of children fathered 0.1 0.1 0.3 -0.2 -0.3 0.3 0.6 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.6 -0.4 1.3 0.7 0.5 0.4
Age at first live birth 1.2 2.1 4.6 -0.4 1.2 0.8 2.0 2.1
Pulse wave peak to peak time 1.2 1.4 2.7 1.2 -1.0 -1.6 -0.8 -1.2
Health satisfaction 0.3 0.5 1.9 -0.3 -1.4 -0.3 0.3 0.3
Shortness of breath walking on level ground 0.9 1.0 2.4 0.4 0.9 0.5 1.6 1.3
Qualifications: College or University degree 0.5 1.5 4.0 0.6 -0.6 -0.9 -2.0 -1.4
Eye problems/disorders: None of the above 0.7 0.9 1.9 -0.3 -1.1 -0.3 1.4 0.9
Mouth/teeth dental problems: Loose teeth 2.9 3.5 6.5 -0.6 1.6 1.4 2.4 2.6
Emphysema/chronic bronchitis 1.0 1.2 4.8 -0.1 -0.1 -0.7 -0.7 -2.2
Medication for pain relief, constipation, heartburn 2.1 3.5 4.9 0.2 -1.9 -2.2 -2.1 -2.2
Neck or shoulder pain in last month 0.1 0.2 0.4 -0.7 0.4 0.1 -0.5 -0.3
Medication: Blood pressure 1.1 1.9 5.4 -2.3 -0.1 1.0 1.3 1.1
Angina (self-reported) 0.6 0.8 2.7 -0.2 0.8 1.6 0.6 0.4
Migraine (self-reported) 0.8 1.0 4.3 -2.1 0.5 0.3 0.7 0.1
Medication: Ibuprofen 1.5 1.8 6.8 2.6 -0.7 -1.0 0.4 0.6
Medication: Allopurinol 0.2 0.3 0.7 -0.4 0.1 0.3 -0.8 -0.9
Medication: Omeprazole 0.4 0.5 1.1 -0.1 0.2 0.6 1.0 1.0
Medication: Seretide 50 evohaler 0.5 0.6 1.5 1.2 0.1 -1.1 0.6 0.2
Mean time to correctly identify matches 2.6 5.0 10.3 -0.6 1.3 1.6 3.2 3.2
Heart disease (mother) 0.9 1.1 3.6 -0.4 -0.5 -0.5 -1.0 -1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.3 -1.0 0.7 1.1 -0.5 -0.5
Whole body fat mass 0.8 3.1 14.2 3.8 -0.8 0.5 -0.1 0.8
Leg fat mass (right) 0.6 2.3 10.1 3.2 -0.7 0.6 -0.4 0.6
Arm predicted mass (right) 0.6 3.2 14.0 3.7 -0.5 -0.0 1.1 0.8
Pulse rate, automated reading 0.5 1.6 7.3 -2.7 -0.6 -0.4 0.3 0.1
Alcohol intake frequency. 0.3 0.6 2.8 -1.7 -0.0 -0.6 -0.3 0.0
Comparative height size at age 10 2.4 13.5 58.8 7.7 -2.6 -1.1 0.1 0.7
Number of full sisters 0.7 0.9 2.0 -1.2 -0.1 0.3 1.4 1.1
Suffer from ‘nerves’ 0.4 0.7 2.8 -1.7 -0.4 -0.6 -0.2 -0.4
Overall health rating 0.1 0.2 0.5 -0.7 -0.1 0.7 -0.3 -0.3
Chest pain or discomfort 0.5 0.8 2.9 -0.6 1.7 0.5 0.5 0.4
Had major operations 1.6 1.9 3.7 1.9 -0.5 -1.4 -1.3 -1.4
Age at last live birth 1.2 1.8 3.7 -0.9 1.2 0.6 1.6 1.9
Family relationship satisfaction 0.8 1.0 2.8 -1.7 0.3 1.4 -0.1 -0.1
Leg pain on walking 0.4 0.5 2.1 1.5 -0.4 0.0 0.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 5.0 -1.5 2.2 2.1 1.7 1.7
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.7 0.6 -0.6 0.1 1.7 1.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.8 0.2 0.3 -0.0 0.2
Medication: Aspirin 5.2 6.8 10.9 -2.2 3.1 3.3 1.9 2.2
Supplements: Vitamin C 0.3 0.3 0.6 -0.8 0.5 0.2 0.6 0.7
Knee pain experienced in last month 0.8 1.3 4.0 2.0 -1.1 0.1 0.6 0.9
Hypertension (Self-reported) 0.6 1.5 5.7 -2.4 0.3 1.1 0.7 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.3 3.6 0.3 1.9 1.8 1.3 1.7
Illnesses of father: Heart disease 0.4 0.5 1.7 0.1 0.4 0.2 1.3 0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.0 -0.7 0.1 -0.4 -0.4
Smoking status: Previous 0.2 0.3 0.7 0.3 0.6 0.6 -0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 9.0 3.0 -1.0 -1.9 -1.1 -1.2
Whole body fat-free mass 0.5 2.7 11.1 3.3 -0.4 0.2 1.1 0.9
Leg fat-free mass (right) 0.3 1.6 6.0 2.5 -0.5 0.2 1.0 0.8
Arm fat percentage (left) 0.3 1.2 3.7 1.9 -1.3 0.1 -1.0 -0.1
Average weekly red wine intake 0.2 0.4 1.3 0.3 -0.1 -0.5 -0.3 -1.1
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 -0.2 -0.3 -0.5 -0.1
Mood swings 0.5 0.8 3.2 -1.8 0.2 0.0 -0.7 -0.6
Loneliness, isolation 0.3 0.4 0.7 -0.8 0.7 0.7 0.2 0.5
Long-standing illness, disability or infirmity 0.4 0.6 1.3 -0.4 1.1 1.2 0.5 -0.2
Ever had bowel cancer screening 0.3 0.4 0.9 -0.0 0.5 0.1 -0.7 -1.0
Diabetes diagnosed by doctor 2.0 3.3 5.3 -1.6 2.3 1.6 1.8 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.9 -0.4 -1.4 -0.6 -0.2 -0.6
Friendships satisfaction 0.9 1.1 3.5 -0.5 0.7 1.9 0.7 0.9
Qualifications: nursing, teaching 0.4 0.7 1.3 -0.8 1.1 1.0 0.6 0.4
Commuting to job workplace: Walk 2.5 2.7 6.8 1.5 -1.5 -2.6 -1.0 -1.2
Eye problems/disorders: Cataract 0.3 0.3 0.8 0.1 0.9 0.7 -0.4 0.1
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.9 -0.5 -0.6 -0.2 -1.7 -1.0
Medication for cholesterol 0.4 0.7 1.4 -0.4 -0.4 -0.7 1.1 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.2 -0.5 0.5 1.1 -0.1 -0.3
Back pain experienced in last month 0.7 1.0 3.1 -1.8 0.1 -0.1 -1.3 -0.5
Mineral and other dietary supplements 1.4 1.9 3.7 1.9 0.6 0.6 1.4 1.8
Breast cancer (self-reported) 0.9 1.1 2.9 1.7 -0.6 0.5 0.8 1.2
Asthma (self-reported) 0.1 0.2 0.8 0.9 0.3 0.2 -0.1 0.1
Osteoporosis (self-reported) 0.8 1.0 2.0 -0.8 1.4 1.0 1.0 0.4
Osteoarthritis (self-reported) 0.4 0.5 0.8 0.9 -0.9 0.3 0.6 0.6
Medication: Aspirin 4.6 5.9 9.9 -2.2 3.0 3.1 1.6 1.9
Medication: Gliclazide 0.6 0.7 1.3 -0.3 1.1 1.1 0.4 0.8
Illnesses of father: None of the above (group 1) 0.3 0.4 1.3 1.2 0.0 -0.5 -0.5 -0.1
Smoking status: Current 0.5 0.8 2.1 -0.1 0.1 0.2 1.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 -1.0 0.7 -0.3 -0.4 -0.1
Whole body water mass 0.5 2.6 11.2 3.3 -0.5 0.1 1.0 0.7
Leg predicted mass (right) 0.3 1.7 6.3 2.5 -0.5 0.3 1.1 0.9
Arm fat mass (left) 0.5 2.0 8.4 2.9 -1.0 0.4 -0.6 0.2
Number of self-reported non-cancer illnesses 0.5 0.9 3.0 -1.7 0.2 0.2 -0.5 -1.0
Average weekly champagne plus white wine intake 0.1 0.1 0.4 0.6 0.0 0.3 -0.2 -0.4
Miserableness 0.2 0.4 0.6 0.2 0.6 0.8 0.7 0.6
Guilty feelings 0.8 1.2 2.0 -0.6 1.1 1.4 1.2 1.0
Wears glasses or contact lenses 0.6 0.7 3.3 -1.8 0.4 0.1 0.4 -0.1
Ever taken oral contraceptive pill 0.6 0.6 1.1 0.4 -1.1 -0.8 -0.9 -0.7
Hearing aid user 0.8 0.9 2.1 1.2 -1.5 -0.7 -0.3 -0.6
Mother’s age at death 0.2 0.2 0.7 -0.2 0.8 -0.6 -0.2 0.1
Financial situation satisfaction 1.9 2.4 3.7 -0.5 -1.3 -1.9 -1.9 -1.7
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.2 -1.1 0.7 0.5 -0.5 -0.4
Commuting to job workplace: Public transport 0.3 0.3 0.7 -0.3 0.3 0.8 0.4 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 1.6 -0.0 -0.0 -0.5 -1.3 -1.0
Medication: Blood pressure 0.5 0.9 2.3 -0.1 0.6 0.3 -1.3 -1.5
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.7 -0.8 -0.1 0.3 0.8 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.1 3.7 -1.9 -0.7 0.1 -0.7 -0.8
High cholesterol (Self-reported) 1.8 3.1 5.2 -1.2 2.1 2.3 1.8 1.1
Medication: Bendroflumethiazide 0.4 0.6 2.0 -0.2 0.5 1.4 0.6 0.5
Medication: Paracetamol 0.1 0.2 0.6 0.8 0.4 0.1 -0.0 -0.1
Medication: Lisinopril 0.8 1.0 4.5 -2.1 0.4 0.4 0.4 0.3
Medication: Atorvastatin 0.9 1.1 1.7 0.3 0.9 1.3 1.2 1.3
Illnesses of father: High blood pressure 0.4 0.5 1.6 -1.3 -0.6 0.2 0.6 0.1
Alcohol drinker status: Never 1.0 1.2 5.9 -2.4 0.1 -0.1 0.3 -0.1
Ever smoked 0.3 0.4 1.0 1.0 -0.2 -0.2 -0.8 -0.7
Basal metabolic rate 0.5 3.0 13.0 3.6 -0.5 0.3 1.0 0.9
Leg fat percentage (left) 0.3 1.0 4.1 2.0 -0.6 0.4 -0.4 0.6
Arm fat-free mass (left) 0.6 3.3 13.1 3.6 -0.1 0.5 1.3 1.2
Number of operations (self-reported) 0.4 0.6 1.6 0.4 0.7 1.3 0.7 0.7
Average weekly beer plus cider intake 0.4 0.6 1.9 0.1 0.6 0.6 0.5 1.4
Irritability 0.4 0.7 1.4 0.7 1.2 0.8 0.6 0.7
Risk taking 1.7 2.5 5.0 0.8 -0.1 -1.7 -1.9 -2.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.7 1.6 0.2 -0.8 -0.0 -0.4
Fractured/broken bones in last 5 years 0.8 1.1 2.6 -0.5 -0.2 -0.8 -1.6 -1.3
Age started oral contraceptive pill 0.4 0.5 1.9 1.4 0.4 0.1 0.1 0.7
Diastolic blood pressure, automated reading 3.3 10.3 45.8 -6.8 1.1 1.5 1.3 0.6
Ever depressed for a whole week 0.1 0.1 0.4 -0.2 0.1 0.2 0.3 0.7
Unable to work because of sickness or disability 0.7 0.8 2.3 -1.5 1.1 0.7 -0.1 -0.3
Commuting to job workplace: Cycle 0.9 1.1 2.5 0.3 -0.2 0.8 1.6 1.4
Myopia 0.0 0.0 0.1 0.2 0.3 0.0 0.2 0.1
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.4 2.3 -0.4 -1.9 -1.4 -0.9
Cholesterol lowering medication 0.1 0.2 0.3 -0.1 0.3 0.5 0.5 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.1 -0.9 0.1 1.0 1.5 1.3
Pain experienced in last month 0.3 0.5 1.1 1.1 -1.0 -0.7 0.0 -0.3
Supplements: Calcium 1.3 1.4 2.6 -1.6 -1.1 -1.4 -0.6 -1.1
Basal cell carcinoma (self-reported) 4.8 5.7 8.8 1.8 -2.3 -3.0 -2.4 -2.4
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.3 0.5 1.4 1.5 0.4 0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 -0.2 -0.8 -0.1 -0.5 -0.8
Heart disease (siblings) 0.5 0.6 1.4 1.2 -0.3 -0.1 -1.0 -0.9
Alcohol drinker status: Previous 1.0 1.1 2.3 -0.4 -0.9 -1.5 -1.0 -1.2
Pack years of smoking 1.0 1.4 3.0 -0.4 0.7 1.2 1.7 1.4
Impedance of whole body 0.4 1.8 7.0 2.6 -1.1 -0.8 -0.2 0.4
Leg fat mass (left) 0.5 2.1 9.0 3.0 -0.7 0.7 -0.0 0.8
Arm predicted mass (left) 0.6 3.3 14.6 3.8 -0.0 0.3 1.0 0.9