Hub : Genes

CEP152

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0250	2.4e-03	0.005	0.011	0.012	0.013	0.008	0.06700	0.016	1.1e-02	0.0096	2.9e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.3860	0.0900	7.1e-05	0.102	NA	0.167	NA	0.131	0.00032	NA	4.0e-06	NA	5.0e-05
3	GTEx	Esophagus Mucosa	0.2140	0.0830	2.0e-03	0.051	NA	0.035	NA	0.029	0.00026	NA	2.0e-03	NA	5.0e-03
4	GTEx	Nerve Tibial	0.1338	0.0490	2.9e-04	0.047	NA	0.030	NA	0.055	0.00027	NA	3.4e-03	NA	9.3e-05
5	TCGA	Brain Lower Grade Glioma	0.0462	0.0248	3.1e-04	0.011	0.023	0.031	NA	0.022	0.01700	0.001	1.6e-04	NA	1.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	1.1	-0.6	0.8	0.8	0.8	1.1
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	-1.3	1.5	0.9	0.8	0.6
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-1.6	0.4	0.7	0.6	0.7
Depression (Nagel 2018)	0.8	1.1	5.3	-2.3	-0.0	0.3	0.2	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	0.2	1.5	0.6	-0.1	-0.3
Neuroticism (Nagel 2018)	0.7	1.7	5.0	-2.2	1.2	1.3	0.4	0.5
Schizophrenia (2018)	0.3	0.7	1.6	-1.2	1.3	0.6	0.3	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.3	0.0	-0.3	0.0	-0.5
Worry (Nagel 2018)	1.0	2.2	9.1	-3.0	0.6	1.1	0.1	0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.8	0.6	0.4	0.3	0.0
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.8	-0.7	-0.3	-0.4	-0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.3	0.2	0.1	0.2	0.3
Crohns Disease (2017)	0.2	0.4	0.9	0.4	-1.0	-0.3	-0.2	0.9
Irritable Bowel Disease (IBD)	0.7	1.6	2.2	1.5	-1.5	-1.5	-1.1	-0.5
Ulcerative Colitis (UC)	1.4	2.7	4.1	1.9	-1.4	-2.0	-1.3	-1.4
Major Depression (MDD)	0.8	1.0	1.9	-0.1	0.7	0.9	1.4	1.3
Reaction Time	2.6	5.0	12.0	-0.4	1.1	1.5	3.0	3.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	1.0	0.5	-0.2	0.3	0.4
Breast Cancer	0.1	0.2	0.5	-0.0	0.5	0.3	0.2	0.7
Ovarian Cancer	1.1	1.4	3.0	-0.3	-0.5	-1.5	-1.2	-1.7
Prostate Cancer	0.3	0.4	0.8	0.7	0.8	0.2	0.2	0.9
Age at First Birth	0.5	0.7	1.8	-1.3	0.9	1.0	-0.2	0.1
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.4	-0.6	-0.1	-0.5	0.8
Body Mass Index (BMI) (2010)	1.7	2.4	6.8	-0.3	2.6	1.9	0.7	1.0
Coronary Artery Disease (CAD)	0.3	0.3	1.4	-1.2	0.0	0.4	-0.2	-0.1
Crohns Disease (2012)	2.0	3.3	7.5	-0.5	0.8	1.5	2.4	2.7
Mean Putamen Volume	0.5	0.6	1.4	0.9	0.2	0.4	0.8	1.2
Fasting Glucose	0.7	0.8	2.0	1.2	-1.4	-0.7	0.1	0.2
HbA1C	0.3	0.4	0.9	-0.7	0.9	0.4	-0.4	-0.4
HDL Cholesterol	0.8	1.4	2.1	0.0	-1.4	-1.4	-1.3	-1.0
LDL Cholesterol	0.5	0.8	1.9	-0.6	1.4	1.4	-0.1	-0.2
Lupus	0.2	0.2	0.6	0.2	0.1	0.0	0.8	0.7
Neuroticism (2016)	0.1	0.1	0.2	-0.3	-0.5	-0.1	-0.1	0.5
Primary Biliary Cirrhosis	0.7	0.9	1.5	0.4	0.5	1.2	1.2	1.2
Rheumatoid Arthritis	1.6	2.2	3.4	-1.5	-1.4	-0.7	-1.9	-1.7
Schizophrenia (2014)	0.5	1.0	4.1	-2.0	0.5	-0.0	0.8	-0.2
Triglycerides	0.5	0.7	1.8	-0.6	-0.7	-0.5	-0.9	-1.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	1.0	-0.3	0.3	0.5	0.4
Ulcerative Colitis	0.5	0.7	2.2	1.5	-0.3	-1.0	0.1	0.4
Blood Eosinophil Count	0.2	1.6	7.8	2.8	-0.0	-0.3	0.1	0.3
Blood Platelet Count	0.2	2.4	6.7	-2.6	-1.4	-1.1	-0.5	-1.4
Blood Red Count	0.1	1.3	3.4	-1.9	0.3	0.4	1.5	0.8
Blood White Count	0.1	0.4	1.0	-1.0	0.0	0.5	0.4	0.8
Heel T-Score	0.2	1.8	3.8	-1.7	-0.7	-1.0	-1.0	-1.9
BMI	0.1	0.4	0.9	0.6	-1.0	-0.0	-0.7	-0.1
Height	1.4	26.6	118.8	10.9	-2.4	-1.6	1.9	1.4
Waist Hip Ratio (WHR)	0.6	2.9	7.6	2.7	0.4	0.3	2.1	1.6
Systolic Blood Pressure	0.2	0.9	2.8	-0.1	-1.7	0.7	0.5	0.9
Smoking Status	0.1	0.2	0.6	0.3	0.8	0.2	0.5	0.5
Allergy or Eczema	0.2	0.6	1.7	-1.3	0.9	0.4	0.2	0.3
Cardiovascular Disease	0.9	3.1	5.4	-2.2	1.2	2.3	1.5	1.3
Hypothyroidism (self reported)	1.2	2.8	3.8	-1.7	-1.9	-1.9	-0.9	-1.8
Respiratory disease	0.6	1.3	3.5	0.1	-0.2	-0.7	-1.6	-1.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	2.9	-1.4	1.7	1.4	1.5	1.7
Lung FEV1/FVC ratio	1.0	4.9	9.0	3.0	-2.0	-3.0	-1.4	-0.9
Lung FVC	1.1	5.8	15.7	-4.0	1.8	1.3	2.2	2.0
Neuroticism	0.3	0.8	1.6	-1.1	0.8	1.3	0.1	0.7
Chronotype (morning person)	0.6	1.3	3.1	1.1	-0.2	0.6	1.7	1.4
Hair Pigment	0.3	9.9	21.7	1.6	-3.5	-4.7	-2.5	-2.6
Tanning	0.3	3.5	6.3	1.8	-0.8	-1.7	-2.0	-2.5
Hand grip strength (left)	0.0	0.1	0.3	-0.5	-0.4	-0.3	-0.2	0.3
Number of treatments/medications taken	0.4	0.6	2.3	-1.5	0.6	0.6	0.3	-0.1
Average weekly spirits intake	0.1	0.2	0.4	-0.5	0.7	-0.1	-0.3	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.0	0.3	0.3	-0.4	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	-1.1	0.4	-0.6	-0.1	-0.7
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.2	-0.2	-0.2	0.7	-0.3
Relative age of first facial hair	0.3	0.7	1.6	-1.3	0.6	0.5	1.0	0.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.0	0.0	-1.2	-1.2	-1.1	-1.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	1.3	0.6	0.0	0.1	0.5
Ever had hysterectomy (womb removed)	0.7	0.7	1.6	-0.8	-0.7	-0.2	1.3	1.0
Systolic blood pressure, automated reading	0.2	0.7	1.3	-0.2	-0.9	0.7	0.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	-0.7	1.3	0.3	1.4	0.6
Angina	0.8	1.0	3.3	-0.3	0.9	1.8	0.7	0.6
Medication for hormone replacement therapy	1.0	1.1	2.4	1.2	-0.3	0.7	-1.5	-1.0
Vitamin and mineral supplements	0.3	0.4	1.0	1.0	-0.1	-0.5	0.3	-0.6
Supplements: Zinc	1.1	1.2	1.4	-1.1	1.0	1.2	1.0	1.2
Medication: Co-codamol	0.2	0.2	0.5	-0.7	0.6	0.4	0.3	0.2
Medication: Metformin	0.9	1.3	2.3	-1.4	0.7	0.5	1.2	1.5
Diabetes (father)	0.3	0.4	0.6	0.8	-0.4	0.5	-0.7	-0.5
Diabetes (mother)	0.4	0.5	1.5	0.5	-0.5	1.2	-0.3	0.5
Severe depression (siblings)	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.5	0.0
Pack years adult smoking proportion	0.6	0.9	2.0	-0.2	0.5	1.0	1.4	1.1
Impedance of leg (right)	0.6	2.9	13.4	3.7	-0.6	-0.8	-0.4	0.4
Leg fat-free mass (left)	0.4	2.0	8.3	2.9	-0.5	0.4	0.7	0.8
Trunk fat percentage	0.6	2.6	10.6	3.2	-1.0	0.5	0.0	1.1
Hand grip strength (right)	0.1	0.3	1.2	-0.2	-1.1	-0.4	-0.2	-0.1
Townsend deprivation index at recruitment	0.8	1.2	2.7	-0.3	1.3	0.8	0.8	1.6
Current tobacco smoking	0.6	0.9	2.2	-0.3	0.5	0.6	1.3	1.5
Average weekly fortified wine intake	0.7	0.8	2.1	0.9	-1.5	-0.6	-0.8	-0.4
Maternal smoking around birth	1.7	2.5	3.9	-0.7	-2.0	-1.2	-1.7	-1.8
Fed-up feelings	0.4	0.7	1.5	1.2	0.2	0.3	0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.6	-0.2	0.3	0.2	0.1
Relative age voice broke	0.7	1.0	4.6	-2.1	-0.4	-0.3	0.5	-0.3
Taking other prescription medications	0.2	0.3	0.5	-0.5	-0.7	-0.7	-0.0	-0.6
Age when periods started (menarche)	0.1	0.2	0.4	0.2	-0.4	-0.5	-0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-1.0	0.2	0.2	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-1.2	-1.1	-0.0	-0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.3	1.5	-0.4	-0.8	-0.8	0.1
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.6	-1.4	-0.4	0.4	1.1
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.3	-0.7	-0.1	-0.6	-1.1
High blood pressure	0.5	1.4	4.8	-2.2	-0.1	1.0	1.1	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.2	0.3	-0.6	-0.4	-0.4
Multivitamins +/- minerals	0.3	0.4	1.0	0.1	-1.0	-0.2	-1.0	-0.0
Stomach or abdominal pain in last month	0.7	0.9	2.5	-0.2	0.0	-1.0	-1.0	-1.6
Supplements: Glucosamine	1.0	1.3	2.8	-0.7	-1.1	-1.2	-0.6	-1.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.0	2.0	-0.5	0.0	-1.8	-1.6
Medication: Atenolol	1.0	1.2	3.7	-0.3	1.3	1.9	0.1	0.7
Medication: Levothyroxine sodium	0.8	1.4	2.0	-1.2	-1.2	-1.4	-0.5	-1.3
Sitting height	0.4	2.9	5.0	1.1	0.3	2.1	1.9	2.2
Chronic bronchitis/emphysema (father)	1.3	1.5	3.6	-0.5	1.9	1.9	0.1	-0.2
High blood pressure (mother)	0.7	1.0	2.7	-1.6	-0.9	-0.5	-1.1	-0.5
Body mass index (BMI)	0.1	0.2	0.6	0.6	-0.2	0.8	-0.5	0.1
Impedance of leg (left)	0.5	2.6	11.0	3.3	-0.8	-0.9	-0.4	0.4
Leg predicted mass (left)	0.4	2.0	8.3	2.9	-0.4	0.4	0.9	0.9
Trunk fat mass	0.8	3.6	15.5	3.9	-1.1	0.5	0.2	1.1
Waist circumference	0.5	2.0	7.7	2.8	-0.0	0.9	0.5	1.1
Number of incorrect matches in round	0.5	0.8	2.0	1.1	-0.1	-0.3	-1.4	-0.6
Past tobacco smoking	0.3	0.6	1.4	-1.2	0.1	0.5	1.0	0.7
Alcohol usually taken with meals	1.1	1.9	3.3	1.3	-0.6	-1.8	-0.9	-1.8
Nervous feelings	0.5	1.0	3.7	-1.9	0.1	0.6	0.7	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.5	-0.4	-1.2	-1.2	-1.6	-1.5
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.5	-0.3	0.2	0.1	-0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.8	-0.1	-0.4	0.9	0.7
Had menopause	1.6	2.0	3.2	0.4	1.1	1.6	1.8	1.8
Had other major operations	0.3	0.4	0.9	-0.7	0.1	0.5	1.0	0.7
Forced vital capacity (FVC)	0.4	1.7	5.4	0.6	0.7	0.3	2.3	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	-0.7	-1.0	-0.5	-0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.3	0.3
Qualifications: None of the above	0.3	0.7	2.2	0.5	-1.5	-0.9	-0.5	-0.2
Financial difficulties in last 2 years	1.3	1.8	3.2	0.8	-0.9	-1.1	-1.8	-1.7
Mouth/teeth dental problems	0.9	1.3	3.5	1.9	-0.2	-0.5	-1.1	-1.3
Heart attack	0.6	0.8	2.2	0.2	1.2	1.5	0.4	0.2
Allergy	0.1	0.2	0.3	-0.6	-0.6	0.0	0.2	0.4
Pain all over the body in last month	0.3	0.3	0.5	-0.5	0.7	0.7	0.5	-0.1
Diabetes (self-reported)	2.2	3.4	5.8	-1.4	2.4	2.1	1.6	1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.6	0.8	-0.3	-0.4	0.1
Medication: Ramipril	0.5	0.7	2.4	1.5	-0.7	-0.4	0.5	-0.0
Medication: Simvastatin	1.5	2.1	7.0	-2.6	0.3	0.8	1.6	0.5
Fluid intelligence score	0.2	0.4	0.8	-0.1	0.5	-0.6	-0.7	-0.9
Illnesses of siblings	0.2	0.3	0.9	0.9	0.3	-0.5	0.2	0.6
Neuroticism score	0.1	0.1	0.3	-0.4	0.4	0.5	-0.1	0.1
Weight	0.7	3.6	16.1	4.0	-0.8	0.5	0.4	0.9
Impedance of arm (right)	0.3	1.3	3.8	2.0	-0.9	-0.9	-1.0	-0.3
Arm fat percentage (right)	0.3	1.1	2.8	1.7	-1.1	0.1	-1.1	-0.1
Trunk fat-free mass	0.5	2.9	11.8	3.4	-0.3	0.2	1.4	0.9
Hip circumference	0.3	1.5	5.7	2.4	-0.9	-0.2	-0.9	-0.2
Time employed in main current job	0.8	1.0	2.9	-1.7	0.3	-0.1	1.2	0.7
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.2	0.5	0.4	-0.1	0.3
Father’s age at death	2.6	3.5	6.7	1.0	-1.6	-2.0	-1.8	-2.6
Worrier / anxious feelings	1.5	2.8	5.6	-2.4	1.4	1.5	1.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.5	-0.1	1.6	1.1	1.5	1.4
Falls in the last year	0.6	0.8	3.5	1.9	-0.2	-0.2	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.4	0.7	0.9	-0.6	-0.6
Number of live births	0.2	0.3	0.5	0.7	-0.6	-0.6	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.2	0.9	0.6	-0.0	1.8	1.1
Pulse rate	0.2	0.3	1.0	-1.0	-0.5	-0.3	0.0	-0.2
Happiness	0.8	1.0	1.6	-0.9	0.3	1.3	1.0	1.3
Noisy workplace	2.5	3.0	8.5	-2.9	-1.7	-1.5	-0.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.3	0.2	-0.3	-1.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.3	1.0	0.5	0.8	0.8
Mouth/teeth dental problems: Dentures	1.3	2.2	4.8	-1.3	-0.3	0.6	2.2	2.0
Asthma	0.1	0.3	1.1	1.0	0.2	0.3	-0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.3	2.3	-0.1	-0.7	0.8	0.9
Medication: Cholesterol lowering	2.6	4.0	5.7	-2.4	1.8	2.2	1.8	1.8
Depression (self-reported)	1.3	1.5	2.7	-1.6	-0.5	-0.9	-1.6	-1.1
Medication: Lansoprazole	0.2	0.3	0.7	-0.4	0.7	0.8	-0.1	-0.2
Prospective memory result	1.5	1.9	3.4	-1.8	1.1	1.7	1.2	0.8
Lung cancer (father)	0.2	0.3	0.7	-0.2	0.1	0.4	-0.8	-0.7
Illnesses of mother	0.9	1.1	4.9	2.2	0.5	0.3	0.3	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.0	0.2	0.5	-0.4	1.0	0.4
Pulse wave Arterial Stiffness index	1.2	1.4	3.1	-0.5	1.0	1.8	0.9	1.4
Impedance of arm (left)	0.4	1.6	5.3	2.3	-1.2	-1.0	-0.6	-0.1
Arm fat mass (right)	0.4	1.7	7.1	2.7	-0.8	0.4	-0.5	0.3
Trunk predicted mass	0.5	2.8	11.5	3.4	-0.4	0.1	1.3	0.8
Standing height	1.4	13.6	59.6	7.7	-1.5	-0.8	1.8	1.6
Length of working week for main job	0.6	0.6	2.5	1.6	-0.5	-0.6	0.0	0.0
Exposure to tobacco smoke at home	0.6	0.6	1.9	1.4	-0.3	-0.3	0.9	0.6
Breastfed as a baby	2.2	2.7	6.7	-0.1	-1.1	-1.4	-1.9	-2.6
Tense / ‘highly strung’	0.1	0.2	0.5	-0.3	0.7	0.3	0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.4	-1.8	1.2	0.3	1.6	0.4
Hair/balding pattern: Pattern 4	0.6	1.4	3.1	0.7	0.2	0.3	1.8	1.8
Birth weight of first child	0.1	0.1	0.3	0.2	-0.4	-0.3	0.4	0.5
Peak expiratory flow (PEF)	0.6	1.4	5.8	2.4	0.5	-1.0	-0.2	-0.2
Pulse wave reflection index	1.4	1.8	4.0	-2.0	1.4	1.4	0.4	0.9
Ever highly irritable/argumentative for 2 days	0.9	1.0	3.3	1.8	-1.1	-0.7	-0.0	-0.0
Loud music exposure frequency	0.2	0.2	0.8	0.1	0.9	0.1	0.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	-0.5	-0.5	-0.7	-0.5	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	-1.0	0.6	0.3	0.3	0.3
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.4	-0.7	0.3	-0.1	-0.5
Medication: Paracetamol	0.6	0.9	1.6	0.8	0.7	0.7	1.2	1.3
Headache pain in last month	0.5	0.8	2.4	-1.6	1.2	-0.0	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	7.5	2.7	-1.1	-1.6	-1.8	-1.6
Glaucoma (self-reported)	0.8	1.0	2.8	-0.3	-0.4	-0.3	-1.7	-1.3
Gout (self-reported)	0.3	0.4	0.9	-0.9	0.7	-0.1	-0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.9	-2.0	-1.0	-0.8	0.7	-0.3
Medication: Amlodipine	0.5	0.7	2.9	-1.7	-0.1	0.6	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.0	0.9	0.1	1.0	0.3
Birth weight	0.2	0.5	2.0	1.4	0.4	-0.2	0.5	-0.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.6	0.7	0.5	0.2	0.9	1.3
High blood pressure (siblings)	0.6	0.9	2.0	-1.4	-0.5	0.6	-0.9	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.3	4.2	-0.3	0.9	0.2	2.0	1.2
Body fat percentage	0.5	2.0	8.4	2.9	-1.0	0.3	-0.5	0.5
Leg fat percentage (right)	0.4	1.4	5.4	2.3	-0.7	0.4	-0.9	0.3
Arm fat-free mass (right)	0.7	3.4	13.4	3.7	-0.2	0.4	1.5	1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.4	0.1	1.2	1.0	0.2	0.9
Comparative body size at age 10	2.5	7.0	12.0	1.8	-1.5	-2.4	-3.5	-3.4
Number of full brothers	0.7	0.9	3.4	1.8	-0.1	1.0	-0.5	-0.1
Worry too long after embarrassment	0.3	0.5	1.3	-1.1	0.6	0.8	-0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.3	-1.8	0.4	-0.4	0.4	-0.4
Wheeze or whistling in the chest in last year	1.4	2.6	4.2	-1.4	1.0	2.0	1.3	2.0
Number of children fathered	0.1	0.1	0.3	-0.2	-0.3	0.3	0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.6	-0.4	1.3	0.7	0.5	0.4
Age at first live birth	1.2	2.1	4.6	-0.4	1.2	0.8	2.0	2.1
Pulse wave peak to peak time	1.2	1.4	2.7	1.2	-1.0	-1.6	-0.8	-1.2
Health satisfaction	0.3	0.5	1.9	-0.3	-1.4	-0.3	0.3	0.3
Shortness of breath walking on level ground	0.9	1.0	2.4	0.4	0.9	0.5	1.6	1.3
Qualifications: College or University degree	0.5	1.5	4.0	0.6	-0.6	-0.9	-2.0	-1.4
Eye problems/disorders: None of the above	0.7	0.9	1.9	-0.3	-1.1	-0.3	1.4	0.9
Mouth/teeth dental problems: Loose teeth	2.9	3.5	6.5	-0.6	1.6	1.4	2.4	2.6
Emphysema/chronic bronchitis	1.0	1.2	4.8	-0.1	-0.1	-0.7	-0.7	-2.2
Medication for pain relief, constipation, heartburn	2.1	3.5	4.9	0.2	-1.9	-2.2	-2.1	-2.2
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.7	0.4	0.1	-0.5	-0.3
Medication: Blood pressure	1.1	1.9	5.4	-2.3	-0.1	1.0	1.3	1.1
Angina (self-reported)	0.6	0.8	2.7	-0.2	0.8	1.6	0.6	0.4
Migraine (self-reported)	0.8	1.0	4.3	-2.1	0.5	0.3	0.7	0.1
Medication: Ibuprofen	1.5	1.8	6.8	2.6	-0.7	-1.0	0.4	0.6
Medication: Allopurinol	0.2	0.3	0.7	-0.4	0.1	0.3	-0.8	-0.9
Medication: Omeprazole	0.4	0.5	1.1	-0.1	0.2	0.6	1.0	1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.5	1.2	0.1	-1.1	0.6	0.2
Mean time to correctly identify matches	2.6	5.0	10.3	-0.6	1.3	1.6	3.2	3.2
Heart disease (mother)	0.9	1.1	3.6	-0.4	-0.5	-0.5	-1.0	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.3	-1.0	0.7	1.1	-0.5	-0.5
Whole body fat mass	0.8	3.1	14.2	3.8	-0.8	0.5	-0.1	0.8
Leg fat mass (right)	0.6	2.3	10.1	3.2	-0.7	0.6	-0.4	0.6
Arm predicted mass (right)	0.6	3.2	14.0	3.7	-0.5	-0.0	1.1	0.8
Pulse rate, automated reading	0.5	1.6	7.3	-2.7	-0.6	-0.4	0.3	0.1
Alcohol intake frequency.	0.3	0.6	2.8	-1.7	-0.0	-0.6	-0.3	0.0
Comparative height size at age 10	2.4	13.5	58.8	7.7	-2.6	-1.1	0.1	0.7
Number of full sisters	0.7	0.9	2.0	-1.2	-0.1	0.3	1.4	1.1
Suffer from ‘nerves’	0.4	0.7	2.8	-1.7	-0.4	-0.6	-0.2	-0.4
Overall health rating	0.1	0.2	0.5	-0.7	-0.1	0.7	-0.3	-0.3
Chest pain or discomfort	0.5	0.8	2.9	-0.6	1.7	0.5	0.5	0.4
Had major operations	1.6	1.9	3.7	1.9	-0.5	-1.4	-1.3	-1.4
Age at last live birth	1.2	1.8	3.7	-0.9	1.2	0.6	1.6	1.9
Family relationship satisfaction	0.8	1.0	2.8	-1.7	0.3	1.4	-0.1	-0.1
Leg pain on walking	0.4	0.5	2.1	1.5	-0.4	0.0	0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	5.0	-1.5	2.2	2.1	1.7	1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.7	0.6	-0.6	0.1	1.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.8	0.2	0.3	-0.0	0.2
Medication: Aspirin	5.2	6.8	10.9	-2.2	3.1	3.3	1.9	2.2
Supplements: Vitamin C	0.3	0.3	0.6	-0.8	0.5	0.2	0.6	0.7
Knee pain experienced in last month	0.8	1.3	4.0	2.0	-1.1	0.1	0.6	0.9
Hypertension (Self-reported)	0.6	1.5	5.7	-2.4	0.3	1.1	0.7	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	3.6	0.3	1.9	1.8	1.3	1.7
Illnesses of father: Heart disease	0.4	0.5	1.7	0.1	0.4	0.2	1.3	0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.0	-0.7	0.1	-0.4	-0.4
Smoking status: Previous	0.2	0.3	0.7	0.3	0.6	0.6	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.0	3.0	-1.0	-1.9	-1.1	-1.2
Whole body fat-free mass	0.5	2.7	11.1	3.3	-0.4	0.2	1.1	0.9
Leg fat-free mass (right)	0.3	1.6	6.0	2.5	-0.5	0.2	1.0	0.8
Arm fat percentage (left)	0.3	1.2	3.7	1.9	-1.3	0.1	-1.0	-0.1
Average weekly red wine intake	0.2	0.4	1.3	0.3	-0.1	-0.5	-0.3	-1.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.5	-0.1
Mood swings	0.5	0.8	3.2	-1.8	0.2	0.0	-0.7	-0.6
Loneliness, isolation	0.3	0.4	0.7	-0.8	0.7	0.7	0.2	0.5
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.4	1.1	1.2	0.5	-0.2
Ever had bowel cancer screening	0.3	0.4	0.9	-0.0	0.5	0.1	-0.7	-1.0
Diabetes diagnosed by doctor	2.0	3.3	5.3	-1.6	2.3	1.6	1.8	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.9	-0.4	-1.4	-0.6	-0.2	-0.6
Friendships satisfaction	0.9	1.1	3.5	-0.5	0.7	1.9	0.7	0.9
Qualifications: nursing, teaching	0.4	0.7	1.3	-0.8	1.1	1.0	0.6	0.4
Commuting to job workplace: Walk	2.5	2.7	6.8	1.5	-1.5	-2.6	-1.0	-1.2
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.1	0.9	0.7	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	-0.5	-0.6	-0.2	-1.7	-1.0
Medication for cholesterol	0.4	0.7	1.4	-0.4	-0.4	-0.7	1.1	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	-0.5	0.5	1.1	-0.1	-0.3
Back pain experienced in last month	0.7	1.0	3.1	-1.8	0.1	-0.1	-1.3	-0.5
Mineral and other dietary supplements	1.4	1.9	3.7	1.9	0.6	0.6	1.4	1.8
Breast cancer (self-reported)	0.9	1.1	2.9	1.7	-0.6	0.5	0.8	1.2
Asthma (self-reported)	0.1	0.2	0.8	0.9	0.3	0.2	-0.1	0.1
Osteoporosis (self-reported)	0.8	1.0	2.0	-0.8	1.4	1.0	1.0	0.4
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.9	-0.9	0.3	0.6	0.6
Medication: Aspirin	4.6	5.9	9.9	-2.2	3.0	3.1	1.6	1.9
Medication: Gliclazide	0.6	0.7	1.3	-0.3	1.1	1.1	0.4	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	1.2	0.0	-0.5	-0.5	-0.1
Smoking status: Current	0.5	0.8	2.1	-0.1	0.1	0.2	1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	-1.0	0.7	-0.3	-0.4	-0.1
Whole body water mass	0.5	2.6	11.2	3.3	-0.5	0.1	1.0	0.7
Leg predicted mass (right)	0.3	1.7	6.3	2.5	-0.5	0.3	1.1	0.9
Arm fat mass (left)	0.5	2.0	8.4	2.9	-1.0	0.4	-0.6	0.2
Number of self-reported non-cancer illnesses	0.5	0.9	3.0	-1.7	0.2	0.2	-0.5	-1.0
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.6	0.0	0.3	-0.2	-0.4
Miserableness	0.2	0.4	0.6	0.2	0.6	0.8	0.7	0.6
Guilty feelings	0.8	1.2	2.0	-0.6	1.1	1.4	1.2	1.0
Wears glasses or contact lenses	0.6	0.7	3.3	-1.8	0.4	0.1	0.4	-0.1
Ever taken oral contraceptive pill	0.6	0.6	1.1	0.4	-1.1	-0.8	-0.9	-0.7
Hearing aid user	0.8	0.9	2.1	1.2	-1.5	-0.7	-0.3	-0.6
Mother’s age at death	0.2	0.2	0.7	-0.2	0.8	-0.6	-0.2	0.1
Financial situation satisfaction	1.9	2.4	3.7	-0.5	-1.3	-1.9	-1.9	-1.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	-1.1	0.7	0.5	-0.5	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.3	0.3	0.8	0.4	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	-0.0	-0.0	-0.5	-1.3	-1.0
Medication: Blood pressure	0.5	0.9	2.3	-0.1	0.6	0.3	-1.3	-1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.7	-0.8	-0.1	0.3	0.8	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.7	-1.9	-0.7	0.1	-0.7	-0.8
High cholesterol (Self-reported)	1.8	3.1	5.2	-1.2	2.1	2.3	1.8	1.1
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.2	0.5	1.4	0.6	0.5
Medication: Paracetamol	0.1	0.2	0.6	0.8	0.4	0.1	-0.0	-0.1
Medication: Lisinopril	0.8	1.0	4.5	-2.1	0.4	0.4	0.4	0.3
Medication: Atorvastatin	0.9	1.1	1.7	0.3	0.9	1.3	1.2	1.3
Illnesses of father: High blood pressure	0.4	0.5	1.6	-1.3	-0.6	0.2	0.6	0.1
Alcohol drinker status: Never	1.0	1.2	5.9	-2.4	0.1	-0.1	0.3	-0.1
Ever smoked	0.3	0.4	1.0	1.0	-0.2	-0.2	-0.8	-0.7
Basal metabolic rate	0.5	3.0	13.0	3.6	-0.5	0.3	1.0	0.9
Leg fat percentage (left)	0.3	1.0	4.1	2.0	-0.6	0.4	-0.4	0.6
Arm fat-free mass (left)	0.6	3.3	13.1	3.6	-0.1	0.5	1.3	1.2
Number of operations (self-reported)	0.4	0.6	1.6	0.4	0.7	1.3	0.7	0.7
Average weekly beer plus cider intake	0.4	0.6	1.9	0.1	0.6	0.6	0.5	1.4
Irritability	0.4	0.7	1.4	0.7	1.2	0.8	0.6	0.7
Risk taking	1.7	2.5	5.0	0.8	-0.1	-1.7	-1.9	-2.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	1.6	0.2	-0.8	-0.0	-0.4
Fractured/broken bones in last 5 years	0.8	1.1	2.6	-0.5	-0.2	-0.8	-1.6	-1.3
Age started oral contraceptive pill	0.4	0.5	1.9	1.4	0.4	0.1	0.1	0.7
Diastolic blood pressure, automated reading	3.3	10.3	45.8	-6.8	1.1	1.5	1.3	0.6
Ever depressed for a whole week	0.1	0.1	0.4	-0.2	0.1	0.2	0.3	0.7
Unable to work because of sickness or disability	0.7	0.8	2.3	-1.5	1.1	0.7	-0.1	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.5	0.3	-0.2	0.8	1.6	1.4
Myopia	0.0	0.0	0.1	0.2	0.3	0.0	0.2	0.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.4	2.3	-0.4	-1.9	-1.4	-0.9
Cholesterol lowering medication	0.1	0.2	0.3	-0.1	0.3	0.5	0.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-0.9	0.1	1.0	1.5	1.3
Pain experienced in last month	0.3	0.5	1.1	1.1	-1.0	-0.7	0.0	-0.3
Supplements: Calcium	1.3	1.4	2.6	-1.6	-1.1	-1.4	-0.6	-1.1
Basal cell carcinoma (self-reported)	4.8	5.7	8.8	1.8	-2.3	-3.0	-2.4	-2.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.3	0.5	1.4	1.5	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.2	-0.8	-0.1	-0.5	-0.8
Heart disease (siblings)	0.5	0.6	1.4	1.2	-0.3	-0.1	-1.0	-0.9
Alcohol drinker status: Previous	1.0	1.1	2.3	-0.4	-0.9	-1.5	-1.0	-1.2
Pack years of smoking	1.0	1.4	3.0	-0.4	0.7	1.2	1.7	1.4
Impedance of whole body	0.4	1.8	7.0	2.6	-1.1	-0.8	-0.2	0.4
Leg fat mass (left)	0.5	2.1	9.0	3.0	-0.7	0.7	-0.0	0.8
Arm predicted mass (left)	0.6	3.3	14.6	3.8	-0.0	0.3	1.0	0.9