TWAS hub - CHD9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0260	0.00028	0.044	0.015	0.028	0.018	0.026	3.8e-06	4.7e-03	0.00022	0.00270	3.2e-04
2	GTEx	Cells Transformed fibroblasts	0.0710	0.0290	0.00390	0.018	NA	0.006	NA	0.003	1.5e-02	NA	0.11000	NA	1.9e-01
3	YFS	Blood	0.0306	0.0119	0.00071	0.015	0.012	0.009	0.010	0.014	6.3e-06	7.1e-05	0.00031	0.00023	1.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3
Age at First Birth	5.2	7.5	21.8	4.7	0.9
Type 2 Diabetes (T2D) (2018)	4.7	8.7	21.0	-4.6	2.3
Diabetes (self-reported)	4.6	7.0	17.3	-4.2	1.9
Lung cancer (father)	4.6	5.4	9.2	-2.6	3.0
Medication: Metformin	3.7	5.2	11.9	-3.4	1.9
Happiness	3.5	4.3	8.8	-3.0	2.0
Medication: Ibuprofen	3.2	3.8	8.9	3.0	-1.6
Diabetes diagnosed by doctor	3.2	5.2	13.7	-3.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	9.3	3.0	-1.5
Bipolar Disorder (2011)	2.9	2.8	7.2	2.7	-1.2
Birth weight of first child	2.9	5.3	11.7	3.4	-2.0
Heart disease (siblings)	2.9	3.5	7.9	1.7	-2.8
Blood Platelet Count	2.8	32.9	57.0	6.5	-7.5
Hair/balding pattern: Pattern 2	2.7	3.4	6.6	2.6	-1.9
Medication for pain relief, constipation, heartburn	2.7	4.6	7.9	-2.8	2.4
HbA1C	2.3	2.5	4.0	1.9	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	9.1	-3.0	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	17.2	-1.6	4.1
Number of full brothers	2.0	2.5	7.4	0.2	-2.7
Medication: Allopurinol	2.0	2.6	5.3	1.6	-2.3
Lupus	1.9	2.8	7.0	1.2	-2.6
Hypothyroidism (self reported)	1.9	4.3	7.1	-2.7	2.4
Loud music exposure frequency	1.9	2.1	3.8	-2.0	1.6
Commuting to job workplace: Walk	1.9	2.0	3.3	1.7	-1.8
Depression (Nagel 2018)	1.8	2.7	8.0	-2.8	-0.2
Suffer from ‘nerves’	1.8	2.8	7.6	2.8	-0.9
Illnesses of siblings: Diabetes	1.8	2.2	3.6	-1.9	1.7
Financial situation satisfaction	1.8	2.2	3.5	-1.8	1.9
Fractured/broken bones in last 5 years	1.8	2.4	3.9	-2.0	1.8
Triglycerides	1.7	2.8	6.9	-2.6	1.2
Birth weight	1.7	3.6	6.5	2.1	-2.5
Number of children fathered	1.7	1.9	3.4	-1.8	1.6
Medication: Levothyroxine sodium	1.6	2.7	4.9	-2.2	1.8
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.1	1.4	-1.8
Alzheimer’s Disease (in mother)	1.4	1.7	3.7	-1.9	1.2
Medication: Co-codamol	1.4	1.6	2.7	-1.6	1.5
Stomach or abdominal pain in last month	1.4	1.7	4.3	0.9	-2.1
Weight	1.4	7.1	12.1	-3.0	3.5
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	4.8	-2.2	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.1	-2.0	-0.6
Lung FEV1/FVC ratio	1.3	6.7	11.8	-2.9	3.4
Hearing difficulty/problems: Yes	1.3	1.9	3.2	-1.8	1.6
Leg fat-free mass (left)	1.3	6.6	12.0	-2.8	3.5
Average weekly fortified wine intake	1.3	1.5	2.4	1.5	-1.5
Sitting height	1.3	9.3	14.8	-3.9	3.6
Leg predicted mass (left)	1.3	7.0	12.6	-2.9	3.5
Hearing difficulty/problems with background noise	1.3	2.0	3.3	-1.8	1.7
Eye problems/disorders: Cataract	1.3	1.5	4.3	-2.1	0.6
Hip circumference	1.2	5.2	8.2	-2.9	2.7
Family relationship satisfaction	1.2	1.5	3.7	-1.0	1.9
Leg fat-free mass (right)	1.2	6.2	11.9	-2.6	3.5
Ever had bowel cancer screening	1.2	1.4	2.6	1.6	-1.3
Back pain experienced in last month	1.2	1.7	4.1	-2.0	-1.0
Leg predicted mass (right)	1.2	6.1	11.6	-2.6	3.4
Alcohol drinker status: Never	1.2	1.4	4.2	0.0	-2.1
Basal metabolic rate	1.2	6.7	13.7	-2.5	3.7
Arm fat-free mass (left)	1.2	6.3	12.9	-2.5	3.6
Breast Cancer	1.1	2.7	8.1	-2.8	-0.2
Mean Putamen Volume	1.1	1.3	1.9	-1.4	1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.6	-0.4	-1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.6	-0.2	1.9
Qualifications: CSEs or equivalent	1.1	1.4	3.5	0.8	-1.9
Serious illness, injury or assault to yourself	1.1	1.3	2.8	-1.1	1.7
High blood pressure (mother)	1.1	1.6	2.8	-1.7	-1.4
Peak expiratory flow (PEF)	1.1	2.6	6.7	-1.1	2.6
Forced vital capacity (FVC), Best measure	1.1	4.1	10.5	-1.3	3.2
Emphysema/chronic bronchitis	1.1	1.2	3.6	-0.1	-1.9
Medication: Blood pressure	1.1	1.9	5.7	0.3	-2.4
Medication: Omeprazole	1.1	1.3	3.5	0.6	-1.9
Whole body fat-free mass	1.1	6.1	12.2	-2.5	3.5
Whole body water mass	1.1	6.0	12.2	-2.4	3.5
Mother’s age at death	1.1	1.4	2.5	-1.2	1.6
Irritability	1.1	1.8	5.4	2.3	-0.2
Diabetes (father)	1.0	1.2	3.6	-1.9	0.3
Financial difficulties in last 2 years	1.0	1.3	3.6	-1.9	0.6
Alcohol intake versus 10 years previously	1.0	1.5	3.7	-1.9	0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	8.9	-0.9	3.0
Illnesses of father: None of the above (group 1)	1.0	1.2	1.9	1.4	1.3
Arm fat mass (left)	1.0	4.0	6.4	-2.5	2.4
Average weekly champagne plus white wine intake	1.0	1.3	2.4	1.6	-1.2
Arm predicted mass (left)	1.0	5.3	11.6	-2.1	3.4
Blood White Count	0.9	6.7	14.1	2.4	-3.8
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	0.4	-1.7
Waist circumference	0.9	3.2	6.6	-2.6	1.8
Nervous feelings	0.9	1.7	5.0	2.2	-0.3
Trunk fat-free mass	0.9	5.3	11.8	-2.0	3.4
Arm fat mass (right)	0.9	3.9	6.1	-2.5	2.4
Trunk predicted mass	0.9	5.0	11.4	-1.9	3.4
Blood clot in the leg (DVT)	0.9	1.1	2.9	-1.7	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.3	0.1	-1.8
Medication for cholesterol	0.9	1.3	3.3	0.8	-1.8
Mineral and other dietary supplements	0.9	1.2	3.0	1.7	-0.8
Medication: Atorvastatin	0.9	1.1	3.2	-1.8	-0.3
Ever smoked	0.9	1.6	2.6	-1.6	1.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.6	1.3	-1.3
Myopia	0.9	1.3	2.5	-1.1	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	2.4	-1.5	0.9
Ulcerative Colitis	0.8	1.1	1.7	-1.3	1.3
Neuroticism	0.8	2.0	5.3	2.3	-0.9
Severe depression (siblings)	0.8	0.9	2.8	0.0	1.7
Maternal smoking around birth	0.8	1.1	3.1	1.8	-0.6
Trunk fat mass	0.8	3.4	6.3	-2.5	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.4	-1.1	1.6
Tense / ‘highly strung’	0.8	1.2	3.1	1.8	-0.8
Eye problems/disorders: None of the above	0.8	0.9	2.8	1.7	-0.0
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.8	0.2	-1.7
Loneliness, isolation	0.8	1.1	2.3	-1.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	1.6	-1.1
Miserableness	0.8	1.4	3.8	-0.7	1.9
Guilty feelings	0.8	1.3	2.7	1.7	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	0.6	-1.7
Supplements: Calcium	0.8	0.9	1.6	-1.1	1.3
Worry (Nagel 2018)	0.7	1.5	4.5	2.1	-0.1
Alzheimer’s Disease (in father)	0.7	0.7	1.8	0.6	-1.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	-1.6	0.7
Reaction Time	0.7	1.3	3.7	0.2	1.9
HDL Cholesterol	0.7	1.2	2.6	0.9	-1.6
Sensitivity / hurt feelings	0.7	1.2	3.2	1.8	-0.6
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.6	-1.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	-1.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.8	1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	2.2	-1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.7	-1.1	1.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	-0.0	1.7
Arm fat percentage (right)	0.7	2.7	5.0	-2.2	1.8
Pulse wave Arterial Stiffness index	0.7	0.9	1.6	-1.0	1.3
Hair/balding pattern: Pattern 4	0.7	1.7	5.1	-2.3	-0.0
Arm fat-free mass (right)	0.7	3.7	8.2	-1.7	2.9
Age at first live birth	0.7	1.3	2.9	-1.0	1.7
Whole body fat mass	0.7	2.9	5.0	-2.2	1.9
Arm predicted mass (right)	0.7	3.7	8.2	-1.7	2.9
Comparative height size at age 10	0.7	3.9	11.0	-0.9	3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.1	0.6	-1.4
Long-standing illness, disability or infirmity	0.7	1.1	2.6	-1.6	0.9
Smoking status: Current	0.7	1.1	2.2	-1.1	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.5	-1.6	0.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.5	-1.6	-0.5
Neuroticism (Nagel 2018)	0.6	1.3	3.5	1.9	-0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.3	-2.1	0.1
BMI	0.6	3.5	6.9	-2.6	1.9
Height	0.6	12.3	26.1	-3.3	5.1
Supplements: Zinc	0.6	0.7	1.9	-1.4	-0.2
Trunk fat percentage	0.6	2.5	5.6	-2.4	1.4
Current tobacco smoking	0.6	1.0	1.7	-1.3	1.1
Supplements: Glucosamine	0.6	0.8	1.9	-1.4	0.7
Medication: Atenolol	0.6	0.8	1.9	-1.4	0.7
Body mass index (BMI)	0.6	2.5	3.8	-2.0	1.9
Had other major operations	0.6	0.7	1.5	1.2	-0.8
Forced vital capacity (FVC)	0.6	2.3	5.9	-1.0	2.4
Illnesses of mother	0.6	0.7	1.2	1.0	1.1
Standing height	0.6	6.0	13.0	-2.3	3.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.1	0.9	1.4
Body fat percentage	0.6	2.3	5.1	-2.2	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-0.5	1.4
Leg fat mass (right)	0.6	2.5	3.8	-1.9	1.9
Age at last live birth	0.6	0.9	2.6	0.2	1.6
Smoking status: Previous	0.6	0.8	1.8	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.2	-1.5	1.3
Arm fat percentage (left)	0.6	2.2	4.3	-2.1	1.5
Leg fat mass (left)	0.6	2.4	3.8	-1.8	1.9
Schizophrenia (2018)	0.5	1.0	1.5	-1.2	1.2
Smoking Status	0.5	1.2	3.5	-1.9	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	-1.4	0.1
Impedance of leg (left)	0.5	2.5	4.6	2.1	-1.7
Fluid intelligence score	0.5	1.0	2.8	-1.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.3	1.3
Gout (self-reported)	0.5	0.6	1.1	1.1	-0.9
Pulse wave peak to peak time	0.5	0.6	1.0	0.8	-1.0
Mean time to correctly identify matches	0.5	1.0	3.1	-0.2	1.8
Friendships satisfaction	0.5	0.6	1.8	0.1	1.4
Breast cancer (self-reported)	0.5	0.6	1.3	1.1	0.6
Hearing aid user	0.5	0.5	1.5	0.2	1.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-0.1	-1.3
Ever depressed for a whole week	0.5	0.6	1.1	1.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	-1.3	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.6	1.3	-0.5
Rheumatoid Arthritis	0.4	0.6	1.2	-1.1	0.7
Number of treatments/medications taken	0.4	0.7	1.3	-1.0	-1.1
Average weekly spirits intake	0.4	0.5	1.4	1.2	-0.1
Relative age voice broke	0.4	0.5	1.2	-0.7	1.1
Taking other prescription medications	0.4	0.6	1.2	-1.1	-0.8
Past tobacco smoking	0.4	0.8	2.3	1.5	-0.2
Pain all over the body in last month	0.4	0.5	1.3	0.2	1.1
Medication: Simvastatin	0.4	0.5	1.6	-1.2	0.1
Neuroticism score	0.4	0.8	2.3	1.5	-0.4
Pulse rate	0.4	0.7	1.9	0.6	-1.4
Medication: Cholesterol lowering	0.4	0.7	1.1	-1.0	-1.0
Pulse wave reflection index	0.4	0.5	1.0	-1.0	0.7
Medication: Paracetamol	0.4	0.7	1.1	1.0	-1.0
Glaucoma (self-reported)	0.4	0.5	1.4	-0.4	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	1.2	-0.4
Health satisfaction	0.4	0.5	1.1	-0.7	1.0
Migraine (self-reported)	0.4	0.4	1.3	0.0	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.8	-0.9
Chest pain or discomfort	0.4	0.6	1.5	1.2	-0.5
Medication: Aspirin	0.4	0.5	1.1	0.6	-1.1
Illnesses of father: Heart disease	0.4	0.5	1.5	-1.2	-0.2
Medication: Gliclazide	0.4	0.4	1.1	-1.0	0.5
Medication: Blood pressure	0.4	0.7	1.1	-1.1	1.0
Medication: Paracetamol	0.4	0.7	1.5	0.8	-1.2
Risk taking	0.4	0.6	1.4	1.2	-0.6
Bipolar Disorder (2018)	0.3	0.4	0.8	0.9	-0.7
Prostate Cancer	0.3	0.4	1.1	0.2	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.8	0.8
Crohns Disease (2012)	0.3	0.5	1.4	0.3	1.2
Fasting Glucose	0.3	0.4	0.9	-0.5	-0.9
Heel T-Score	0.3	2.6	6.9	2.6	1.0
Chronotype (morning person)	0.3	0.6	1.0	1.0	-0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.1	0.2	-1.0
Impedance of leg (right)	0.3	1.6	2.5	1.6	-1.6
Hand grip strength (right)	0.3	0.9	2.6	0.5	1.6
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.5	1.0
Mouth/teeth dental problems	0.3	0.4	1.3	-0.3	1.1
Asthma	0.3	0.6	1.4	-1.2	-0.6
Medication: Lansoprazole	0.3	0.3	1.0	-1.0	-0.2
Length of working week for main job	0.3	0.3	0.7	0.8	-0.5
Leg fat percentage (right)	0.3	1.2	2.7	-1.6	0.9
Shortness of breath walking on level ground	0.3	0.3	0.8	-0.9	0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.6	-0.8
Alcohol intake frequency.	0.3	0.7	2.0	-1.4	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	-1.0	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	0.2	-0.9
Knee pain experienced in last month	0.3	0.4	1.0	-0.4	1.0
Hypertension (Self-reported)	0.3	0.8	2.3	-0.1	-1.5
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.5	-1.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.3	-1.1	-0.6
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.9	0.4
Leg fat percentage (left)	0.3	1.1	2.3	-1.5	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.6	0.2	1.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	-0.7
Alcohol drinker status: Previous	0.3	0.3	0.8	0.9	0.4
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.6	0.9
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.8	0.6
Major Depression (MDD)	0.2	0.2	0.5	-0.7	-0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	-0.2
Schizophrenia (2014)	0.2	0.5	1.1	-0.7	1.0
Blood Eosinophil Count	0.2	1.5	3.5	1.0	1.9
Blood Red Count	0.2	2.1	5.5	2.4	0.9
Allergy or Eczema	0.2	0.6	1.8	1.3	-0.3
Cardiovascular Disease	0.2	0.7	2.2	0.1	-1.5
Lung FVC	0.2	1.1	3.1	0.5	1.8
Tanning	0.2	2.2	3.8	-1.7	1.9
Hand grip strength (left)	0.2	0.5	0.7	0.8	-0.9
Relative age of first facial hair	0.2	0.4	1.1	-0.1	1.1
Angina	0.2	0.3	0.5	0.7	-0.5
Pack years adult smoking proportion	0.2	0.3	0.6	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.8	0.7
High blood pressure	0.2	0.6	1.9	-0.1	-1.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.4	0.6
Alcohol usually taken with meals	0.2	0.3	0.9	-0.4	0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.1	0.9
Qualifications: None of the above	0.2	0.4	1.3	-0.0	-1.1
Heart attack	0.2	0.3	0.6	-0.8	-0.5
Allergy	0.2	0.5	1.4	1.2	-0.2
Illnesses of siblings	0.2	0.3	0.8	-0.1	0.9
Worrier / anxious feelings	0.2	0.4	0.9	0.9	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.9	-0.1
Noisy workplace	0.2	0.2	0.7	-0.8	0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	0.6	1.0
Depression (self-reported)	0.2	0.2	0.5	-0.4	-0.7
Exposure to tobacco smoke at home	0.2	0.3	0.7	-0.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.9	-0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	0.8	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.1	0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.4	0.8
Worry too long after embarrassment	0.2	0.4	0.7	0.6	-0.9
Had major operations	0.2	0.2	0.5	-0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.9	-0.1
Asthma (self-reported)	0.2	0.5	1.4	-1.2	-0.2
Wears glasses or contact lenses	0.2	0.3	0.8	0.3	0.9
Medication: Bendroflumethiazide	0.2	0.4	1.0	-1.0	0.3
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.6	0.8
Commuting to job workplace: Cycle	0.2	0.2	0.3	0.6	0.5
Pain experienced in last month	0.2	0.3	0.7	0.9	-0.1
Impedance of whole body	0.2	1.0	1.8	1.1	-1.3
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	-0.4	0.5
Crohns Disease (2017)	0.1	0.3	0.6	0.7	-0.5
Ovarian Cancer	0.1	0.1	0.3	-0.6	-0.4
LDL Cholesterol	0.1	0.2	0.5	-0.7	-0.2
Neuroticism (2016)	0.1	0.1	0.4	0.6	0.1
Waist Hip Ratio (WHR)	0.1	0.6	1.9	-0.1	-1.4
Systolic Blood Pressure	0.1	0.7	1.2	1.0	-1.1
Hair Pigment	0.1	1.9	5.4	-0.6	-2.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.7	-0.7
Fed-up feelings	0.1	0.1	0.3	-0.6	0.3
Multivitamins +/- minerals	0.1	0.1	0.4	-0.2	-0.6
Had menopause	0.1	0.2	0.5	0.1	0.7
Medication: Ramipril	0.1	0.1	0.3	-0.3	0.6
Time employed in main current job	0.1	0.1	0.3	0.5	0.2
Father’s age at death	0.1	0.1	0.3	0.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.1	-0.6
Falls in the last year	0.1	0.2	0.5	0.1	0.7
Number of live births	0.1	0.2	0.4	-0.7	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.2	-0.7
Prospective memory result	0.1	0.1	0.3	-0.1	-0.6
Impedance of arm (left)	0.1	0.3	1.0	0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.5	-0.2
Headache pain in last month	0.1	0.1	0.3	-0.6	0.0
Medication: Amlodipine	0.1	0.2	0.5	0.0	-0.7
High blood pressure (siblings)	0.1	0.1	0.2	0.4	-0.4
Comparative body size at age 10	0.1	0.4	0.9	1.0	-0.5
Wheeze or whistling in the chest in last year	0.1	0.3	0.5	-0.7	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.1	0.7
Angina (self-reported)	0.1	0.1	0.2	0.5	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.5	0.1
Pulse rate, automated reading	0.1	0.2	0.5	-0.3	-0.7
Number of full sisters	0.1	0.1	0.2	0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.5
Mood swings	0.1	0.2	0.5	0.7	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.4	0.2	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.1	0.3	0.3
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.6	0.4
Illnesses of father: High blood pressure	0.1	0.1	0.4	0.6	-0.2
Age started oral contraceptive pill	0.1	0.1	0.4	-0.1	-0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.9	0.9	-0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	-0.3
Pack years of smoking	0.1	0.1	0.4	0.1	0.7
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.2	-0.4
Respiratory disease	0.0	0.1	0.1	-0.4	0.3
Medication for hormone replacement therapy	0.0	0.0	0.1	0.2	-0.1
Vitamin and mineral supplements	0.0	0.0	0.0	-0.0	-0.1
Diabetes (mother)	0.0	0.0	0.1	-0.3	0.1
Age when periods started (menarche)	0.0	0.1	0.2	-0.5	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.4	0.3
Number of incorrect matches in round	0.0	0.1	0.2	-0.5	-0.0
Impedance of arm (right)	0.0	0.1	0.3	-0.1	-0.6
Breastfed as a baby	0.0	0.0	0.0	-0.0	0.1
Qualifications: College or University degree	0.0	0.1	0.3	-0.0	-0.5
Heart disease (mother)	0.0	0.0	0.1	-0.1	-0.3
Overall health rating	0.0	0.0	0.1	-0.2	0.3
Leg pain on walking	0.0	0.0	0.1	0.2	0.3
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	0.1
Average weekly red wine intake	0.0	0.0	0.1	0.3	-0.1
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.4	-0.1
Medication: Aspirin	0.0	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	0.2	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.4	0.1
Medication: Lisinopril	0.0	0.0	0.1	0.4	-0.0
Number of operations (self-reported)	0.0	0.0	0.1	0.1	-0.3
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	0.3
Cholesterol lowering medication	0.0	0.0	0.1	-0.1	0.3

Hub : Genes

CHD9

Models

Trait associations