TWAS hub - CHSY1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1930	0.0530	0.0001	0.025	NA	0.046	NA	0.056	5.0e-03	NA	2.2e-04	NA	5.1e-05
2	NTR	Blood	0.0313	0.0132	0.0150	0.033	0.004	0.027	0.030	0.029	6.4e-11	1.6e-02	4.5e-09	5.3e-10	9.9e-10
3	YFS	Blood	0.2441	0.0246	0.0000	0.276	0.240	0.281	0.281	0.281	9.4e-91	2.3e-77	7.9e-93	1.5e-92	9.8e-93

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood White Count	7.1	52.4	82.4	1.4	-9.1	-8.5
Medication: Amlodipine	4.3	6.1	9.8	0.8	3.1	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	7.5	0.4	2.7	2.6
Length of working week for main job	4.0	4.4	5.8	1.8	-2.4	-2.1
Commuting to job workplace: Cycle	3.8	4.6	8.2	0.3	-2.9	-2.4
Mouth/teeth dental problems: Bleeding gums	3.6	4.7	7.1	1.0	-2.7	-2.5
Gout (self-reported)	3.6	5.0	8.0	0.0	2.8	2.6
Medication: Ibuprofen	3.3	4.0	7.3	-0.4	-2.7	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	7.3	0.8	-2.7	-2.2
Chronic bronchitis/emphysema (father)	3.2	3.8	5.6	0.8	-2.2	-2.4
Leg pain on walking	3.2	4.0	5.1	1.6	2.3	2.1
Medication: Blood pressure	2.9	5.0	6.5	2.1	2.6	2.0
Hearing difficulty/problems: Yes	2.8	4.3	4.7	2.0	-2.2	-2.0
Pulse wave Arterial Stiffness index	2.8	3.2	4.8	0.7	-2.2	-2.1
Miserableness	2.7	4.7	6.4	1.4	-2.5	-2.4
Triglycerides	2.6	4.2	6.4	-0.4	2.5	2.5
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	5.7	-1.0	-2.4	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.3	-1.5	2.1	1.6
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	3.3	-1.5	1.7	1.8
Eye problems/disorders: None of the above	2.4	2.8	5.5	2.4	-1.1	-1.3
Diastolic blood pressure, automated reading	2.4	7.4	8.6	2.4	2.9	2.8
Heart disease (siblings)	2.4	3.0	5.2	0.8	2.3	1.8
Pulse wave peak to peak time	2.3	2.7	4.0	-0.7	2.0	1.9
Medication: Bendroflumethiazide	2.3	3.5	9.5	3.1	0.9	0.3
Supplements: Glucosamine	2.2	2.9	4.7	2.2	-1.3	-1.5
Happiness	2.2	2.6	4.5	0.6	-2.1	-1.7
Long-standing illness, disability or infirmity	2.2	3.4	5.7	2.4	-1.5	-1.4
Illnesses of father: None of the above (group 1)	2.2	2.7	5.9	-2.4	0.9	1.2
Prostate Cancer	2.1	3.0	7.0	-2.7	-1.2	-0.8
Systolic blood pressure, automated reading	2.1	6.0	8.9	0.9	2.9	3.0
High blood pressure	2.1	5.9	6.8	2.6	2.6	2.1
Breast cancer (self-reported)	2.1	2.5	3.5	0.8	-1.9	-1.9
Wears glasses or contact lenses	2.1	2.4	3.0	1.4	1.7	1.5
Serious illness, injury or assault to yourself	2.0	2.5	4.0	-0.1	-2.0	-1.8
Hypertension (Self-reported)	2.0	5.7	7.0	2.2	2.6	2.3
Mood swings	2.0	3.6	4.5	1.4	-2.0	-2.1
Body Mass Index (BMI) (2010)	1.9	2.6	7.7	2.8	0.1	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.6	0.4	-2.1	-1.8
Glaucoma (self-reported)	1.9	2.2	5.9	-2.4	0.5	0.7
Heart disease (mother)	1.9	2.3	3.3	0.5	1.8	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.1	0.5	-1.6	-2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	3.1	1.8	-1.4	-1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.1	-0.4	-1.8	-1.8
Osteoporosis (self-reported)	1.8	2.2	2.8	-1.1	-1.6	-1.7
Illnesses of father: High blood pressure	1.8	2.2	5.6	2.4	-0.8	-0.6
HDL Cholesterol	1.7	2.9	4.6	0.2	-2.0	-2.1
Illnesses of siblings	1.7	2.3	3.1	-1.3	-1.8	-1.5
Age at last live birth	1.7	2.5	3.3	-1.5	1.4	1.8
Eye problems/disorders: Glaucoma	1.7	2.0	5.0	-2.2	0.5	0.8
Medication: Atorvastatin	1.7	2.1	2.4	-1.5	1.6	1.3
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.7	-0.2	1.9	1.5
Vascular/heart problems diagnosed by doctor	1.7	4.6	5.8	-2.2	-2.4	-1.9
Age when periods started (menarche)	1.6	3.8	5.2	-2.3	-1.8	-1.8
Nervous feelings	1.6	2.9	8.8	-3.0	-0.1	0.0
Emphysema/chronic bronchitis	1.6	1.8	3.0	-0.5	1.4	1.7
Medication: Metformin	1.5	2.2	4.9	2.2	-1.1	-0.7
Fed-up feelings	1.5	2.8	3.8	1.3	-2.0	-1.7
Taking other prescription medications	1.5	2.4	6.4	2.5	0.6	0.7
Hayfever, allergic rhinitis or eczema	1.5	3.2	4.3	1.2	-2.1	-1.9
Alzheimer’s Disease (in father)	1.4	1.6	4.3	2.1	-0.4	-0.5
Townsend deprivation index at recruitment	1.4	2.0	5.5	2.4	0.4	0.6
Peak expiratory flow (PEF)	1.4	3.2	9.3	-3.1	-0.2	-0.3
Medication: Allopurinol	1.4	1.9	2.8	0.7	1.7	1.6
Breast Cancer	1.3	3.0	4.5	0.8	-2.0	-2.1
Age at First Birth	1.3	1.9	2.6	1.6	-1.4	-1.1
Mean Putamen Volume	1.3	1.5	3.0	1.7	-1.0	-0.8
Systolic Blood Pressure	1.3	6.7	10.0	0.8	3.1	3.2
Severe depression (siblings)	1.3	1.5	4.2	2.0	-0.5	-0.0
Trunk fat percentage	1.3	5.1	10.2	3.2	-1.7	-1.5
Hair/balding pattern: Pattern 4	1.3	3.2	4.9	0.4	-2.1	-2.2
Alcohol drinker status: Never	1.3	1.5	1.9	-1.4	1.0	1.2
Sensitivity / hurt feelings	1.2	2.1	3.2	-0.1	-1.8	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.0	1.4	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	4.0	-0.5	-2.0	-1.9
Medication: Co-codamol	1.1	1.3	2.1	1.4	1.1	0.8
Financial difficulties in last 2 years	1.1	1.5	2.4	1.5	-1.1	-1.1
Mouth/teeth dental problems	1.1	1.6	3.0	-0.4	1.7	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.0	0.6	-1.7	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.4	1.1	1.2	1.2
Pulse wave reflection index	1.1	1.4	4.1	-2.0	-0.3	0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	1.5	1.1	-1.2	-1.1
High blood pressure (siblings)	1.1	1.6	3.2	1.8	-0.9	-0.9
Number of full sisters	1.1	1.4	2.2	-0.6	1.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.3	1.8	-0.4	-0.6
Illnesses of father: Heart disease	1.1	1.5	2.3	1.0	-1.2	-1.5
Back pain experienced in last month	1.1	1.6	2.6	-0.3	1.5	1.6
Number of self-reported non-cancer illnesses	1.1	1.8	5.4	2.3	0.3	0.0
Hearing aid user	1.1	1.2	1.6	1.0	-1.0	-1.2
Supplements: Zinc	1.0	1.1	1.5	0.9	-1.1	-1.2
Maternal smoking around birth	1.0	1.4	2.2	0.4	-1.3	-1.5
Trunk fat mass	1.0	4.2	7.7	2.8	-1.6	-1.5
Had other major operations	1.0	1.3	1.8	1.3	-1.0	-1.0
Body fat percentage	1.0	3.8	8.4	2.9	-1.3	-1.1
Pulse rate, automated reading	1.0	3.1	4.6	-0.3	-2.1	-2.1
Family relationship satisfaction	1.0	1.3	1.6	0.9	-1.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.6	0.4	-0.9	-1.6
Arm fat percentage (left)	1.0	4.1	9.7	3.1	-1.2	-1.0
Ever had bowel cancer screening	1.0	1.2	2.1	-0.6	1.4	1.1
Financial situation satisfaction	1.0	1.3	1.6	1.0	-1.3	-1.1
Average weekly beer plus cider intake	1.0	1.4	2.1	-1.1	1.5	1.0
Waist circumference	0.9	3.1	9.4	3.1	-0.0	0.1
Neuroticism score	0.9	1.9	2.5	0.9	-1.6	-1.6
Pulse rate	0.9	1.5	2.1	0.9	-1.4	-1.3
Medication: Lansoprazole	0.9	1.0	1.3	0.7	1.1	1.1
Illnesses of mother	0.9	1.1	1.6	-1.2	-1.1	-0.6
Loneliness, isolation	0.9	1.2	2.7	-1.6	-0.9	-0.5
Mineral and other dietary supplements	0.9	1.2	2.6	-1.6	0.6	0.8
Ever taken oral contraceptive pill	0.9	1.1	2.4	1.6	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.8	-1.7	-0.2	-0.2
Allergy or Eczema	0.8	2.1	3.2	0.4	-1.8	-1.8
Cardiovascular Disease	0.8	2.5	5.9	2.4	1.0	0.7
Diabetes (mother)	0.8	1.0	1.5	0.5	1.2	1.1
Sitting height	0.8	5.9	9.0	0.4	-3.0	-2.9
Pain all over the body in last month	0.8	0.9	1.1	1.0	-0.9	-0.8
Diabetes (self-reported)	0.8	1.2	2.8	1.7	0.7	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.8	0.1	-1.2	-1.3
Mouth/teeth dental problems: Dentures	0.8	1.4	2.3	-0.5	1.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.5	-1.6	-1.1	-0.7
Health satisfaction	0.8	1.0	2.6	1.6	0.4	0.6
Arm fat mass (left)	0.8	3.2	6.6	2.6	-1.4	-1.1
Lung FEV1/FVC ratio	0.7	3.6	5.9	-0.5	-2.4	-2.1
Number of treatments/medications taken	0.7	1.3	3.9	2.0	0.1	0.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	1.0	-0.6	-1.0
Angina	0.7	0.9	1.6	0.1	1.3	1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-1.2	0.5	0.6
Multivitamins +/- minerals	0.7	0.9	2.0	1.4	0.8	0.5
Medication: Simvastatin	0.7	1.0	2.9	1.7	-0.2	-0.3
Arm fat percentage (right)	0.7	2.7	6.2	2.5	-1.1	-0.9
Arm fat mass (right)	0.7	3.0	5.3	2.3	-1.5	-1.2
Whole body fat mass	0.7	3.0	6.2	2.5	-1.3	-1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.0	1.4	-0.5	-0.6
Diabetes diagnosed by doctor	0.7	1.1	2.6	1.6	0.5	0.6
Osteoarthritis (self-reported)	0.7	0.9	2.3	1.5	-0.5	-0.5
Major Depression (MDD)	0.6	0.7	1.2	1.1	-0.7	-0.7
LDL Cholesterol	0.6	0.9	1.6	0.6	0.8	1.3
Waist Hip Ratio (WHR)	0.6	2.6	7.3	2.7	-0.3	-0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	1.8	-0.3	-0.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.0	-0.4	-1.0	-1.0
Allergy	0.6	1.5	2.3	-1.5	1.0	1.1
Medication: Paracetamol	0.6	1.0	1.5	-0.8	-1.2	-0.9
Medication for pain relief, constipation, heartburn	0.6	1.0	1.5	-0.8	1.2	0.9
Angina (self-reported)	0.6	0.8	1.4	-0.1	1.2	1.0
Knee pain experienced in last month	0.6	1.0	2.5	1.6	0.3	0.6
Medication: Aspirin	0.6	0.8	1.2	1.1	0.8	0.7
High cholesterol (Self-reported)	0.6	1.1	1.2	1.0	-1.1	-1.1
Medication: Paracetamol	0.6	0.9	2.0	-1.4	-0.8	-0.4
Medication: Lisinopril	0.6	0.7	1.0	-0.4	1.0	1.0
Depression (Nagel 2018)	0.5	0.7	1.1	0.1	-1.0	-1.0
Crohns Disease (2017)	0.5	1.1	2.6	-1.6	-0.7	-0.5
Irritable Bowel Disease (IBD)	0.5	1.1	3.2	-1.8	0.2	0.5
Rheumatoid Arthritis	0.5	0.7	1.8	-1.4	0.2	0.5
Ulcerative Colitis	0.5	0.8	1.1	-0.4	1.1	1.1
Height	0.5	10.6	13.6	-2.7	-3.3	-3.7
Respiratory disease	0.5	1.1	1.6	-0.6	1.1	1.3
Average weekly fortified wine intake	0.5	0.6	1.8	-1.3	-0.3	0.0
Father’s age at death	0.5	0.7	1.3	-0.1	-0.9	-1.2
Noisy workplace	0.5	0.6	1.1	-0.4	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.5	-2.1	-0.5	-0.5
Birth weight	0.5	1.0	1.9	-1.4	-0.7	-0.8
Exposure to tobacco smoke outside home	0.5	0.6	1.1	-0.2	0.9	1.1
Worry too long after embarrassment	0.5	0.9	1.4	1.2	-0.8	-0.8
Qualifications: College or University degree	0.5	1.5	4.2	2.0	-0.4	-0.2
Neck or shoulder pain in last month	0.5	0.7	1.4	0.1	1.2	0.8
Migraine (self-reported)	0.5	0.6	0.9	0.1	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	1.4	0.1	-0.1
Supplements: Vitamin C	0.5	0.6	0.7	0.8	-0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.7	1.3	0.1	0.2
Eye problems/disorders: Cataract	0.5	0.6	1.0	-0.4	1.0	0.8
Medication for cholesterol	0.5	0.8	2.2	-1.5	0.1	0.3
Commuting to job workplace: Public transport	0.5	0.6	0.6	-0.7	0.8	0.8
Ever depressed for a whole week	0.5	0.6	1.2	1.1	-0.6	-0.5
Cholesterol lowering medication	0.5	0.8	1.3	-0.0	1.0	1.1
Bipolar Disorder (2018)	0.4	0.6	0.9	0.5	0.9	0.9
Crohns Disease (2012)	0.4	0.6	1.7	-1.3	-0.3	-0.3
Leg fat-free mass (left)	0.4	1.9	2.9	1.7	-1.3	-1.0
Stomach or abdominal pain in last month	0.4	0.5	0.8	0.5	0.9	0.8
Medication: Atenolol	0.4	0.5	0.7	0.6	0.8	0.7
Body mass index (BMI)	0.4	1.6	4.5	2.1	-0.5	-0.2
Leg predicted mass (left)	0.4	1.9	3.1	1.8	-1.3	-1.0
Number of incorrect matches in round	0.4	0.7	1.0	0.7	1.0	0.8
Had menopause	0.4	0.5	1.1	1.0	0.5	0.4
Qualifications: None of the above	0.4	0.8	2.0	-1.4	0.2	0.6
Impedance of arm (right)	0.4	1.7	2.9	0.3	-1.5	-1.7
Falls in the last year	0.4	0.6	1.3	1.1	0.2	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-0.7	0.7	1.0
Number of live births	0.4	0.6	0.6	-0.7	0.8	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.7	-1.3	-1.0	-1.1
Lung cancer (father)	0.4	0.4	0.6	0.1	-0.8	-0.8
Impedance of arm (left)	0.4	1.7	2.4	1.0	-1.3	-1.5
Breastfed as a baby	0.4	0.5	1.4	1.2	0.2	-0.1
Birth weight of first child	0.4	0.7	1.0	-1.0	-0.8	-0.6
Leg fat percentage (right)	0.4	1.4	3.5	1.9	-0.7	-0.5
Shortness of breath walking on level ground	0.4	0.4	0.9	0.1	0.6	0.9
Overall health rating	0.4	0.9	1.0	1.0	0.9	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.6	-0.6	0.7	0.8
Medication: Aspirin	0.4	0.5	1.2	1.1	0.4	0.4
Risk taking	0.4	0.6	1.0	-0.4	1.0	0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.0	0.4	-1.0	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.8	-0.3	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	1.1	-0.0	-0.3
Ulcerative Colitis (UC)	0.3	0.5	0.6	-0.8	0.6	0.7
Reaction Time	0.3	0.6	1.1	0.1	-0.9	-1.0
Primary Biliary Cirrhosis	0.3	0.5	0.7	-0.7	-0.8	-0.6
BMI	0.3	1.8	4.6	2.1	-0.8	-0.3
Hair Pigment	0.3	8.3	13.1	-0.6	3.4	3.6
Vitamin and mineral supplements	0.3	0.4	1.0	-1.0	-0.0	0.1
Impedance of leg (right)	0.3	1.6	2.3	-1.0	-1.2	-1.5
Hand grip strength (right)	0.3	0.8	1.1	-1.1	0.9	0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	0.5	0.4
High blood pressure (mother)	0.3	0.4	0.7	0.6	0.8	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.7	0.7	-0.5	-0.8
Weight	0.3	1.5	2.4	1.6	-1.1	-0.9
Asthma	0.3	0.6	1.7	1.3	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	1.0	-0.2	-0.6
Headache pain in last month	0.3	0.4	0.9	-0.4	-0.9	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	2.4	-1.5	-0.8	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.9	1.0	-0.3	-0.4
Leg fat mass (right)	0.3	1.3	2.8	1.7	-0.9	-0.6
Had major operations	0.3	0.3	0.6	-0.3	-0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.9	-0.4	-0.4
Medication: Gliclazide	0.3	0.4	0.6	0.5	-0.8	-0.6
Smoking status: Current	0.3	0.5	0.7	0.3	-0.8	-0.8
Leg predicted mass (right)	0.3	1.4	2.7	1.6	-1.1	-0.7
Mother’s age at death	0.3	0.4	0.8	0.9	0.6	0.2
Medication: Blood pressure	0.3	0.5	0.7	0.9	0.6	0.6
Ever smoked	0.3	0.5	0.8	0.1	-0.8	-0.9
Leg fat percentage (left)	0.3	1.2	3.5	1.9	-0.3	-0.1
Supplements: Calcium	0.3	0.3	0.4	0.6	-0.5	-0.6
Leg fat mass (left)	0.3	1.2	2.9	1.7	-0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.4	0.7	1.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.8	0.1	-0.2
Schizophrenia (2014)	0.2	0.5	1.0	0.1	1.0	0.7
Smoking Status	0.2	0.6	1.2	-1.1	0.6	0.5
Chronotype (morning person)	0.2	0.5	1.0	0.1	0.8	1.0
Hand grip strength (left)	0.2	0.6	0.8	-0.6	0.9	0.7
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	0.6	0.3
Diabetes (father)	0.2	0.2	0.3	0.6	0.3	0.5
Pack years adult smoking proportion	0.2	0.3	0.4	-0.2	0.6	0.7
Current tobacco smoking	0.2	0.3	0.5	0.1	-0.7	-0.7
Relative age voice broke	0.2	0.3	0.7	0.1	-0.8	-0.5
Alcohol usually taken with meals	0.2	0.3	0.9	-1.0	-0.1	0.2
Forced vital capacity (FVC)	0.2	0.9	1.5	-0.5	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-0.0	0.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.8	-0.2	-0.2
Medication: Ramipril	0.2	0.3	0.6	-0.2	0.8	0.6
Hip circumference	0.2	0.8	1.8	1.4	-0.6	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.9	-0.2	-0.4
Worrier / anxious feelings	0.2	0.4	0.5	0.7	0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.3	1.0	1.0	0.1	0.2
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	0.4	0.1
Prospective memory result	0.2	0.3	0.7	-0.8	0.3	0.3
Standing height	0.2	2.2	3.2	-0.9	-1.6	-1.8
Tense / ‘highly strung’	0.2	0.3	0.8	-0.9	0.3	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.3	0.5	0.5
Loud music exposure frequency	0.2	0.2	0.3	-0.4	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.6	0.6	0.6	0.8
Number of full brothers	0.2	0.2	0.4	-0.1	-0.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.3	0.6	0.4	0.5
Medication: Omeprazole	0.2	0.2	0.6	0.0	0.8	0.3
Mean time to correctly identify matches	0.2	0.4	0.7	0.1	-0.6	-0.8
Suffer from ‘nerves’	0.2	0.3	0.5	0.0	-0.7	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.1	0.6	0.6
Smoking status: Previous	0.2	0.3	0.5	-0.2	0.7	0.6
Leg fat-free mass (right)	0.2	1.3	2.7	1.6	-1.0	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.7	0.8	-0.3	-0.3
Asthma (self-reported)	0.2	0.4	1.0	1.0	-0.2	-0.2
Whole body water mass	0.2	0.9	1.0	1.0	-1.0	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.9	0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.9	-0.3	-0.3
Basal metabolic rate	0.2	1.4	1.6	1.3	-1.2	-1.0
Irritability	0.2	0.3	0.4	0.7	0.6	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.8	0.3	0.4
Age started oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.0	0.4
Unable to work because of sickness or disability	0.2	0.3	0.8	0.9	-0.1	0.0
Myopia	0.2	0.2	0.4	0.2	-0.5	-0.7
Pain experienced in last month	0.2	0.3	0.4	0.3	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.9	0.0	-0.1
Pack years of smoking	0.2	0.3	0.5	-0.2	0.6	0.7
Impedance of whole body	0.2	0.9	1.6	-0.2	-1.0	-1.2
Ovarian Cancer	0.1	0.1	0.3	-0.5	-0.2	-0.1
Fasting Glucose	0.1	0.1	0.3	0.1	0.4	0.5
HbA1C	0.1	0.1	0.3	0.6	0.2	0.3
Blood Eosinophil Count	0.1	1.0	2.6	1.6	0.6	0.3
Heel T-Score	0.1	0.5	1.3	1.1	0.1	0.2
Lung FVC	0.1	0.3	1.0	1.0	-0.0	-0.1
Neuroticism	0.1	0.3	0.6	0.3	-0.6	-0.8
Tanning	0.1	1.1	1.2	0.9	-1.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.3	0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.2	0.5	0.8
Impedance of leg (left)	0.1	0.7	1.3	-1.1	-0.5	-0.7
Past tobacco smoking	0.1	0.1	0.2	-0.4	0.1	0.3
Trunk fat-free mass	0.1	0.4	0.6	0.4	-0.8	-0.7
Depression (self-reported)	0.1	0.1	0.3	0.5	0.0	-0.0
Trunk predicted mass	0.1	0.5	0.7	0.4	-0.9	-0.8
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	0.2	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	0.4	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	0.3	0.2
Arm fat-free mass (right)	0.1	0.4	0.5	0.7	-0.7	-0.5
Comparative body size at age 10	0.1	0.2	0.4	0.2	-0.6	-0.4
Number of children fathered	0.1	0.1	0.1	0.3	0.2	-0.2
Age at first live birth	0.1	0.2	0.5	-0.7	0.0	0.4
Arm predicted mass (right)	0.1	0.6	0.9	0.9	-0.8	-0.6
Comparative height size at age 10	0.1	0.7	1.3	1.2	0.8	0.4
Chest pain or discomfort	0.1	0.2	0.2	0.5	-0.3	-0.4
Whole body fat-free mass	0.1	0.8	0.9	0.9	-0.9	-0.7
Average weekly red wine intake	0.1	0.2	0.5	-0.7	-0.2	-0.2
Friendships satisfaction	0.1	0.1	0.2	0.2	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.7	0.4	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.0	0.2
Arm fat-free mass (left)	0.1	0.3	0.5	0.3	-0.7	-0.5
Number of operations (self-reported)	0.1	0.2	0.5	0.7	-0.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.7	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	0.1	0.4	-0.2
Arm predicted mass (left)	0.1	0.5	0.7	0.7	-0.9	-0.6
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.2	0.5	0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Schizophrenia (2018)	0.0	0.1	0.2	-0.2	-0.1	-0.4
Worry (Nagel 2018)	0.0	0.1	0.2	0.1	-0.3	-0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	0.3	-0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.1	-0.2
Lupus	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.1	0.1	-0.0	-0.3
Blood Platelet Count	0.0	0.1	0.2	-0.1	-0.4	-0.0
Blood Red Count	0.0	0.1	0.4	-0.6	-0.1	0.1
Hypothyroidism (self reported)	0.0	0.0	0.0	0.1	0.1	0.2
Average weekly spirits intake	0.0	0.0	0.0	0.1	-0.2	-0.0
Relative age of first facial hair	0.0	0.0	0.1	-0.2	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	0.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.1	0.1	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.3	-0.2	0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.4	-0.0	0.1
Heart attack	0.0	0.0	0.0	0.2	-0.1	-0.2
Fluid intelligence score	0.0	0.1	0.1	-0.3	-0.0	0.4
Time employed in main current job	0.0	0.0	0.0	-0.0	-0.2	0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	0.4	0.2	0.0
Alcohol intake frequency.	0.0	0.0	0.1	0.0	-0.2	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.3	-0.2	-0.2
Guilty feelings	0.0	0.0	0.1	-0.3	0.1	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.2	-0.1	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.1	0.3	-0.2	-0.0

Hub : Genes

CHSY1

Models

Trait associations