Hub : Genes

CKLF

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.1400 0.0560 3.6e-03 0.002 NA -0.004 NA -0.003 2.1e-01 NA 8.4e-01 NA 6.4e-01
2 GTEx Testis 0.3520 0.0910 5.0e-05 0.192 NA 0.149 NA 0.171 6.4e-09 NA 3.9e-07 NA 4.8e-08
3 NTR Blood 0.0215 0.0083 9.9e-05 0.020 0.007 0.010 0.015 0.015 2.9e-07 0.0014 2.6e-04 6.5e-06 8.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.7 1.8 -1.4 -0.2 0.3
Bipolar Disorder or Schizophrenia 0.8 2.0 3.1 -1.6 0.6 1.8
Depressed Affect (Nagel 2018) 0.6 1.2 2.3 -0.9 -1.5 0.7
Depression (Nagel 2018) 1.1 1.7 4.7 -0.6 -2.2 -0.1
Intelligence (Savage-Jansen 2018) 1.2 3.7 6.1 0.4 2.2 -2.5
Neuroticism (Nagel 2018) 1.2 2.9 4.7 -1.8 -2.2 -0.8
Schizophrenia (2018) 0.9 1.8 3.6 -1.0 0.9 1.9
Schizophrenia vs Biploar Disorder 1.1 1.5 2.3 0.0 1.4 1.5
Worry (Nagel 2018) 1.4 2.9 4.4 -2.0 -0.5 -2.1
Alzheimer’s Disease (in mother) 0.8 1.0 2.5 0.4 -1.6 -0.5
Alzheimer’s Disease (in father) 3.3 3.6 5.4 -0.7 -2.2 2.3
Alzheimer’s Disease (including proxy) 2.2 3.2 7.6 -1.0 -2.8 1.0
Crohns Disease (2017) 0.1 0.1 0.2 -0.3 0.4 0.4
Irritable Bowel Disease (IBD) 0.4 0.9 1.3 -1.1 1.1 -0.4
Ulcerative Colitis (UC) 0.9 1.7 2.4 -1.5 1.3 -0.9
Major Depression (MDD) 0.1 0.1 0.3 0.1 -0.3 -0.5
Reaction Time 0.4 0.8 1.9 0.5 -0.5 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.3 -0.6 1.0 -1.1
Breast Cancer 0.9 2.3 5.5 -1.0 -2.3 -0.5
Ovarian Cancer 0.2 0.2 0.4 -0.2 -0.5 -0.6
Prostate Cancer 0.6 0.9 1.5 0.4 -1.2 -0.9
Age at First Birth 1.1 1.6 2.8 -0.9 1.7 -1.1
Bipolar Disorder (2011) 1.8 1.7 3.3 -0.3 -1.8 1.3
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 0.5 0.0 -0.3
Coronary Artery Disease (CAD) 0.1 0.2 0.4 -0.6 -0.1 0.3
Crohns Disease (2012) 0.5 0.8 1.4 0.9 1.2 -0.2
Mean Putamen Volume 0.4 0.4 0.9 -1.0 -0.4 0.4
Fasting Glucose 1.1 1.3 2.6 -0.7 -1.6 1.0
HbA1C 0.3 0.3 0.7 0.2 0.4 -0.8
HDL Cholesterol 2.2 3.6 6.2 -2.1 -2.5 0.2
LDL Cholesterol 0.9 1.4 2.1 -1.5 -1.4 -0.3
Lupus 0.2 0.4 1.0 1.0 -0.2 0.3
Neuroticism (2016) 0.5 0.8 1.9 -0.2 -0.7 1.4
Primary Biliary Cirrhosis 0.7 1.0 1.7 -1.3 -0.6 1.0
Rheumatoid Arthritis 1.6 2.2 2.5 1.4 -1.6 1.4
Schizophrenia (2014) 1.0 2.3 4.0 -1.1 1.2 2.0
Triglycerides 1.2 2.0 5.0 0.9 0.3 -2.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.4 1.6 -0.0 -0.1
Ulcerative Colitis 1.3 1.9 5.2 -0.6 2.3 0.1
Blood Eosinophil Count 0.2 1.6 4.6 -0.2 -0.2 2.1
Blood Platelet Count 0.1 0.8 1.3 0.3 -1.0 1.1
Blood Red Count 0.1 0.7 1.9 0.3 -0.1 1.4
Blood White Count 0.5 3.4 4.5 2.1 -2.1 1.2
Heel T-Score 1.2 9.8 27.2 -0.3 5.2 -1.4
BMI 0.5 2.6 5.1 1.1 -2.2 1.3
Height 0.3 5.7 13.8 0.8 1.6 3.7
Waist Hip Ratio (WHR) 0.6 2.8 8.2 2.9 0.3 0.1
Systolic Blood Pressure 0.2 1.2 2.6 -0.9 1.6 0.5
Smoking Status 0.2 0.6 1.6 0.1 -1.3 0.3
Allergy or Eczema 0.7 1.9 4.7 0.7 2.2 -0.7
Cardiovascular Disease 0.3 1.0 2.0 -1.4 -1.0 -0.1
Hypothyroidism (self reported) 1.1 2.4 6.4 -0.6 -2.5 -0.6
Respiratory disease 0.1 0.2 0.5 0.7 -0.1 -0.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.9 0.5 -1.7 -0.2
Lung FEV1/FVC ratio 1.0 5.0 6.6 2.3 1.8 2.6
Lung FVC 1.0 5.1 15.4 -0.1 0.1 -3.9
Neuroticism 0.4 1.1 1.9 -1.4 -1.0 -0.5
Chronotype (morning person) 1.4 3.2 5.2 -0.5 2.3 2.0
Hair Pigment 0.3 8.5 14.7 0.6 -3.8 -3.2
Tanning 0.1 0.9 1.7 0.5 1.3 0.9
Hand grip strength (left) 0.6 1.6 2.1 1.5 1.4 0.8
Number of treatments/medications taken 0.4 0.7 1.9 -0.4 -1.4 -0.0
Average weekly spirits intake 1.1 1.3 3.9 2.0 0.0 -0.2
Sensitivity / hurt feelings 1.5 2.6 5.8 -2.4 -1.4 0.1
Frequency of depressed mood in last 2 weeks 0.8 1.2 1.9 -1.4 -1.3 0.2
Hearing difficulty/problems: Yes 0.9 1.4 3.5 -1.9 -0.8 -0.1
Relative age of first facial hair 0.0 0.1 0.1 -0.3 -0.3 -0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.4 -0.6 -0.5 0.0
Ever used hormone-replacement therapy (HRT) 1.2 1.6 3.4 -1.9 -0.3 -1.1
Ever had hysterectomy (womb removed) 2.3 2.6 4.2 -0.6 -2.0 -1.8
Systolic blood pressure, automated reading 0.3 0.8 1.9 -1.4 0.7 0.2
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 1.8 -1.0 -1.2 -1.3
Angina 2.7 3.5 6.8 -1.4 -2.6 -1.4
Medication for hormone replacement therapy 0.2 0.3 0.5 -0.3 -0.4 -0.7
Vitamin and mineral supplements 0.6 0.8 1.9 0.5 1.4 -0.6
Supplements: Zinc 0.5 0.5 0.8 0.9 -0.7 0.5
Medication: Co-codamol 2.1 2.5 4.7 -2.2 -0.1 -1.6
Medication: Metformin 0.2 0.2 0.7 -0.0 -0.9 -0.1
Diabetes (father) 3.5 4.4 10.6 1.0 -3.3 1.3
Diabetes (mother) 0.1 0.2 0.4 -0.2 -0.2 0.6
Severe depression (siblings) 0.4 0.4 0.6 0.7 -0.8 -0.4
Pack years adult smoking proportion 1.1 1.6 2.9 -1.3 -1.7 -0.4
Impedance of leg (right) 0.1 0.4 0.8 0.2 0.9 -0.6
Leg fat-free mass (left) 0.4 2.3 5.4 1.1 -0.5 2.3
Trunk fat percentage 1.2 4.8 8.6 1.0 -2.9 2.2
Hand grip strength (right) 0.3 0.8 1.4 1.2 1.0 0.2
Townsend deprivation index at recruitment 1.3 1.8 3.5 0.7 -1.9 -1.2
Current tobacco smoking 0.8 1.3 2.0 -0.5 -1.4 1.3
Average weekly fortified wine intake 0.3 0.4 0.6 -0.7 0.7 0.1
Maternal smoking around birth 0.3 0.5 1.1 -0.4 -0.3 1.1
Fed-up feelings 0.9 1.6 4.1 -0.9 -2.0 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.1 0.6 -1.8 -0.5
Relative age voice broke 0.3 0.5 1.3 -1.2 -0.2 0.4
Taking other prescription medications 1.1 1.7 4.8 -0.0 -2.2 -0.4
Age when periods started (menarche) 0.5 1.3 3.1 1.8 0.5 -0.7
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 8.1 -0.1 -2.8 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 11.1 -0.5 3.3 -1.0
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 3.9 0.4 0.1 -2.0
Qualifications: CSEs or equivalent 1.5 2.0 4.8 2.2 0.2 -1.0
Serious illness, injury or assault to yourself 2.3 2.7 5.9 -1.5 0.3 -2.4
High blood pressure 0.4 1.2 2.9 -1.7 -0.4 -0.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.8 0.7 0.9 -0.3
Multivitamins +/- minerals 0.5 0.6 1.0 0.1 -1.0 0.8
Stomach or abdominal pain in last month 1.5 1.9 3.5 -0.7 -1.3 1.9
Supplements: Glucosamine 0.3 0.4 0.8 -0.1 0.7 0.9
Diverticular disease/diverticulitis (self-reported) 4.5 5.4 6.6 -2.6 2.4 2.0
Medication: Atenolol 0.9 1.2 1.9 -1.3 -0.2 -1.4
Medication: Levothyroxine sodium 0.2 0.4 0.7 0.4 -0.6 -0.8
Sitting height 0.5 3.5 6.7 1.9 2.6 0.3
Chronic bronchitis/emphysema (father) 1.0 1.2 1.8 -0.8 1.4 -1.0
High blood pressure (mother) 0.3 0.4 0.9 1.0 0.5 -0.3
Body mass index (BMI) 1.0 4.2 9.8 0.3 -3.1 1.7
Impedance of leg (left) 0.0 0.1 0.2 -0.3 0.3 -0.5
Leg predicted mass (left) 0.4 2.2 4.9 1.1 -0.5 2.2
Trunk fat mass 1.2 5.2 7.3 1.1 -2.7 2.7
Waist circumference 0.9 3.2 7.3 0.6 -2.7 1.4
Number of incorrect matches in round 1.6 2.6 7.6 -2.8 0.0 0.4
Past tobacco smoking 0.4 0.8 2.3 -0.4 -0.0 1.5
Alcohol usually taken with meals 4.8 7.8 15.2 -3.9 2.9 0.1
Nervous feelings 0.7 1.3 2.5 -1.6 -0.3 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.6 -1.3 -0.9 0.3
Hearing difficulty/problems with background noise 0.5 0.8 2.1 -0.4 -1.5 0.3
Hair/balding pattern: Pattern 2 3.3 4.1 6.8 2.6 -1.0 2.1
Had menopause 1.1 1.3 3.4 -1.8 -0.3 -0.7
Had other major operations 1.4 1.7 2.7 -1.4 -0.8 1.6
Forced vital capacity (FVC) 0.5 1.8 2.8 1.7 1.0 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.3 7.0 -1.1 2.7 -1.3
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 3.7 -1.9 -0.5 0.0
Qualifications: None of the above 0.9 1.9 4.9 0.1 -2.2 0.8
Financial difficulties in last 2 years 1.3 1.8 5.3 0.0 -0.3 2.3
Mouth/teeth dental problems 0.4 0.7 1.3 1.1 -0.4 -0.7
Heart attack 0.7 0.8 2.5 -0.0 -1.6 -0.2
Allergy 0.1 0.1 0.2 -0.5 -0.4 0.2
Pain all over the body in last month 1.9 2.1 3.5 -1.9 -1.3 1.0
Diabetes (self-reported) 0.2 0.4 1.1 -1.0 -0.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 -0.4 -0.9 -0.6
Medication: Ramipril 0.9 1.1 2.2 1.0 -1.5 0.5
Medication: Simvastatin 0.7 1.1 2.7 -0.2 -1.7 -0.7
Fluid intelligence score 0.5 1.0 1.8 0.9 1.4 -0.7
Illnesses of siblings 1.1 1.6 2.7 1.4 0.3 1.7
Neuroticism score 0.8 1.7 3.3 -1.8 -1.3 -0.3
Weight 0.7 3.6 6.7 0.9 -1.8 2.6
Impedance of arm (right) 0.1 0.7 1.5 0.7 1.2 0.0
Arm fat percentage (right) 1.3 5.0 9.1 0.9 -3.0 2.2
Trunk fat-free mass 0.4 2.3 6.4 0.5 0.5 2.5
Hip circumference 1.1 4.6 9.2 -1.1 -3.0 1.8
Time employed in main current job 0.7 0.8 2.0 -0.5 -1.4 -0.2
Alcohol intake versus 10 years previously 1.7 2.6 4.3 2.1 1.3 -1.3
Father’s age at death 0.4 0.6 1.0 1.0 -0.5 0.7
Worrier / anxious feelings 0.8 1.5 3.0 -0.9 0.9 -1.7
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.9 -1.3 -2.2 -0.8
Falls in the last year 1.8 2.4 4.0 0.1 -1.8 -2.0
Hair/balding pattern: Pattern 3 0.7 1.0 1.6 -1.2 0.3 -1.3
Number of live births 1.9 2.6 7.1 0.8 0.4 2.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 5.3 2.3 1.7 -0.4
Pulse rate 1.1 1.8 3.9 1.1 -2.0 -0.6
Happiness 1.3 1.6 4.5 -0.5 2.1 -0.2
Noisy workplace 0.5 0.6 0.8 -0.9 -0.6 0.7
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.8 1.0 1.4 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.8 0.3 0.6 1.7
Mouth/teeth dental problems: Dentures 0.4 0.6 1.1 -0.8 -0.4 1.0
Asthma 0.2 0.4 0.8 0.9 -0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.1 1.3 -1.8 -0.7
Medication: Cholesterol lowering 1.0 1.6 4.2 0.1 -2.0 -0.7
Depression (self-reported) 1.0 1.2 1.7 1.1 -1.3 -0.7
Medication: Lansoprazole 0.7 0.8 1.6 -0.9 -1.3 0.2
Prospective memory result 0.6 0.7 1.5 -1.2 -0.5 0.6
Lung cancer (father) 0.8 0.9 1.7 -0.8 -1.3 0.7
Illnesses of mother 0.2 0.2 0.7 0.8 0.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 2.6 1.6 1.6 -0.5
Pulse wave Arterial Stiffness index 1.7 1.9 4.9 -0.1 -0.9 2.2
Impedance of arm (left) 0.2 0.8 1.7 1.3 0.8 0.1
Arm fat mass (right) 1.2 4.8 6.9 0.7 -2.6 2.6
Trunk predicted mass 0.4 2.4 6.7 0.6 0.5 2.6
Standing height 0.4 4.4 7.2 1.0 2.7 2.2
Length of working week for main job 0.5 0.6 1.3 -0.1 -1.1 -0.6
Exposure to tobacco smoke at home 1.5 1.7 2.6 1.6 0.1 1.6
Breastfed as a baby 0.6 0.8 1.2 -0.6 0.9 1.1
Tense / ‘highly strung’ 0.4 0.7 1.5 -1.2 -0.6 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 1.4 1.0 -1.2 0.7
Hair/balding pattern: Pattern 4 1.5 3.7 4.4 -1.9 2.1 -1.7
Birth weight of first child 0.3 0.6 1.5 1.2 0.2 0.4
Peak expiratory flow (PEF) 1.3 3.0 4.7 1.9 2.2 0.8
Pulse wave reflection index 0.9 1.1 1.7 -1.3 -0.6 1.1
Ever highly irritable/argumentative for 2 days 1.2 1.5 3.3 -0.9 -1.8 0.6
Loud music exposure frequency 0.3 0.4 0.8 -0.9 0.4 0.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 1.7 1.1 1.3 -1.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.8 -0.4 1.4 0.7
Blood clot in the leg (DVT) 0.6 0.8 2.3 -1.5 0.3 0.1
Medication: Paracetamol 0.4 0.6 1.0 -0.1 -1.0 -0.9
Headache pain in last month 0.9 1.6 3.7 -0.3 -1.9 1.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.8 0.1 0.9 0.6
Glaucoma (self-reported) 1.1 1.3 1.8 0.8 -1.4 -1.2
Gout (self-reported) 0.3 0.4 0.7 0.8 -0.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 1.5 -0.6 -1.2 -0.8
Medication: Amlodipine 0.1 0.2 0.5 0.0 0.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.8 2.3 3.2 1.5 -1.8 -1.2
Birth weight 0.8 1.8 3.5 1.3 -0.6 1.9
Chronic bronchitis/emphysema (mother) 1.1 1.3 1.9 -1.2 -0.7 1.4
High blood pressure (siblings) 1.3 1.8 4.0 -2.0 -0.1 -1.2
Forced vital capacity (FVC), Best measure 0.4 1.3 2.3 1.0 0.8 -1.5
Body fat percentage 1.5 5.8 12.0 0.7 -3.5 2.2
Leg fat percentage (right) 1.5 5.3 14.5 0.0 -3.8 1.2
Arm fat-free mass (right) 0.4 2.2 5.2 0.7 -0.9 2.3
Exposure to tobacco smoke outside home 0.5 0.7 1.4 0.7 -1.2 -0.5
Comparative body size at age 10 1.1 3.1 5.8 -1.7 0.8 2.4
Number of full brothers 0.4 0.5 0.8 0.2 -0.8 0.9
Worry too long after embarrassment 0.4 0.6 1.3 -1.2 -0.2 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.6 0.8 0.1 0.1
Wheeze or whistling in the chest in last year 0.6 1.0 2.2 -0.8 -0.2 1.5
Number of children fathered 0.9 1.0 2.4 1.5 0.8 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.8 1.4 0.1 -0.8
Age at first live birth 0.8 1.5 2.1 -1.4 0.6 -1.4
Pulse wave peak to peak time 1.5 1.8 4.4 0.3 0.9 -2.1
Health satisfaction 1.5 1.9 4.4 -2.1 -0.6 1.0
Shortness of breath walking on level ground 0.6 0.7 1.3 -0.6 -1.2 0.5
Qualifications: College or University degree 0.2 0.5 0.8 -0.5 0.9 -0.6
Eye problems/disorders: None of the above 2.3 2.6 5.4 2.3 1.3 0.9
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.3 1.1 -0.0 -0.5
Emphysema/chronic bronchitis 1.7 1.9 2.7 -1.6 -1.6 0.7
Medication for pain relief, constipation, heartburn 0.5 0.9 2.2 -0.2 1.5 0.6
Neck or shoulder pain in last month 1.2 1.7 2.9 -1.7 -1.3 0.7
Medication: Blood pressure 0.3 0.6 1.3 0.3 -0.6 -1.1
Angina (self-reported) 2.4 3.2 6.7 -1.1 -2.6 -1.3
Migraine (self-reported) 1.5 1.8 2.9 1.7 -1.4 -0.7
Medication: Ibuprofen 1.8 2.2 6.0 0.7 -2.5 -0.1
Medication: Allopurinol 0.3 0.4 0.7 0.7 -0.8 0.0
Medication: Omeprazole 1.6 1.9 3.1 -1.8 -0.2 1.6
Medication: Seretide 50 evohaler 0.3 0.4 0.9 0.9 0.0 0.5
Mean time to correctly identify matches 0.3 0.6 1.2 -0.1 -0.7 -1.1
Heart disease (mother) 0.4 0.4 1.3 -1.1 -0.0 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.4 0.7 0.6 1.5
Whole body fat mass 1.4 5.7 9.5 0.8 -3.1 2.6
Leg fat mass (right) 1.3 5.1 11.4 0.7 -3.4 1.9
Arm predicted mass (right) 0.4 2.0 4.9 0.8 -0.8 2.2
Pulse rate, automated reading 1.8 5.8 15.3 1.0 -3.9 -1.0
Alcohol intake frequency. 0.5 1.1 2.5 -1.6 -0.9 -0.4
Comparative height size at age 10 0.3 1.5 2.6 -0.6 1.6 1.3
Number of full sisters 0.7 0.9 2.5 1.6 -0.2 -0.1
Suffer from ‘nerves’ 0.5 0.8 2.0 -1.4 -0.6 -0.2
Overall health rating 1.2 2.6 6.9 -1.0 -2.6 0.1
Chest pain or discomfort 1.9 2.7 3.9 -1.3 -1.6 -2.0
Had major operations 0.9 1.0 2.7 -0.6 -1.6 -0.1
Age at last live birth 0.3 0.5 1.1 -1.1 -0.5 0.2
Family relationship satisfaction 2.4 2.9 8.4 -0.3 2.9 -0.5
Leg pain on walking 1.2 1.4 3.1 -1.1 0.1 1.8
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 1.8 -1.1 1.3 0.6
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.6 -1.6 -0.6 -0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 0.7 -0.5 -1.0
Medication: Aspirin 0.7 0.9 1.3 -1.2 -1.1 0.3
Supplements: Vitamin C 0.7 0.8 2.1 -1.5 -0.3 -0.4
Knee pain experienced in last month 0.6 1.0 1.8 -0.4 -1.3 1.0
Hypertension (Self-reported) 0.5 1.3 3.0 -1.7 -0.5 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.8 -0.1 0.4 0.9
Illnesses of father: Heart disease 0.3 0.4 0.6 0.6 -0.5 0.8
Illnesses of siblings: Diabetes 0.2 0.2 0.3 -0.6 0.4 0.3
Smoking status: Previous 0.6 0.9 2.2 0.7 0.3 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.4 0.6 -0.3 1.2
Whole body fat-free mass 0.4 2.1 5.7 0.7 -0.1 2.4
Leg fat-free mass (right) 0.4 2.0 5.0 0.8 -0.6 2.2
Arm fat percentage (left) 1.6 6.4 11.5 1.3 -3.4 2.4
Average weekly red wine intake 2.9 4.3 9.2 -1.7 0.8 3.0
Handedness (chirality/laterality): Left-handed 0.9 1.0 2.1 -0.8 0.7 -1.4
Mood swings 0.4 0.7 2.0 -0.3 -0.1 1.4
Loneliness, isolation 0.5 0.7 1.6 -0.7 0.2 1.3
Long-standing illness, disability or infirmity 0.1 0.2 0.4 0.6 -0.3 -0.1
Ever had bowel cancer screening 0.9 1.0 2.0 -1.0 1.4 -0.4
Diabetes diagnosed by doctor 0.2 0.4 0.8 -0.2 -0.9 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.4 -1.2 0.5 0.3
Friendships satisfaction 0.5 0.6 1.5 0.3 1.2 0.3
Qualifications: nursing, teaching 1.0 1.5 4.6 0.0 0.0 -2.2
Commuting to job workplace: Walk 0.6 0.6 1.7 1.3 0.5 -0.0
Eye problems/disorders: Cataract 1.9 2.2 3.2 -1.8 -1.3 1.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.2 -1.1 0.9 0.4
Medication for cholesterol 0.6 1.0 2.6 1.6 -0.2 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.9 -1.4 -0.7 -0.6
Back pain experienced in last month 1.2 1.7 4.8 -0.6 -2.2 0.2
Mineral and other dietary supplements 0.1 0.1 0.3 0.2 -0.3 -0.5
Breast cancer (self-reported) 0.7 0.8 1.6 -1.3 0.2 -0.8
Asthma (self-reported) 0.2 0.4 0.6 0.8 -0.8 -0.1
Osteoporosis (self-reported) 1.2 1.5 4.5 -2.1 -0.3 0.3
Osteoarthritis (self-reported) 0.4 0.6 1.3 -1.1 -0.6 -0.1
Medication: Aspirin 0.8 1.1 2.1 -1.4 -1.0 0.5
Medication: Gliclazide 0.3 0.4 0.6 -0.3 0.6 0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 -0.6 0.5 -0.4
Smoking status: Current 0.8 1.2 2.7 -0.4 -1.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.1 7.4 0.9 2.7 -1.1
Whole body water mass 0.4 2.1 5.7 0.7 -0.1 2.4
Leg predicted mass (right) 0.4 2.0 5.0 0.9 -0.6 2.2
Arm fat mass (left) 1.3 5.4 8.1 1.2 -2.8 2.6
Number of self-reported non-cancer illnesses 0.8 1.4 2.5 -1.1 -1.6 -0.7
Average weekly champagne plus white wine intake 3.3 4.5 12.6 -3.5 0.5 0.8
Miserableness 0.7 1.2 1.7 -1.0 -1.3 1.0
Guilty feelings 0.8 1.2 1.9 -1.0 -0.8 1.4
Wears glasses or contact lenses 2.0 2.3 3.4 -1.9 -1.8 -0.5
Ever taken oral contraceptive pill 0.5 0.5 0.6 -0.8 0.5 0.8
Hearing aid user 0.7 0.8 1.7 -0.7 -1.3 0.4
Mother’s age at death 0.9 1.2 2.2 -1.0 1.5 -0.6
Financial situation satisfaction 0.6 0.7 2.0 0.3 1.4 0.3
Tinnitus: Yes, now most or all of the time 1.9 2.2 4.8 -0.6 1.2 2.2
Commuting to job workplace: Public transport 1.5 1.7 3.4 1.2 1.9 0.6
Eye problems/disorders: Glaucoma 1.8 2.1 4.2 0.4 -1.4 -2.1
Medication: Blood pressure 0.5 1.0 2.2 -1.5 0.9 0.4
Pain type(s) experienced in last month: Hip pain 1.1 1.3 3.8 -0.4 -1.9 0.3
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.5 -0.1 0.7 1.6
High cholesterol (Self-reported) 0.4 0.7 1.8 0.1 -1.3 -0.5
Medication: Bendroflumethiazide 0.2 0.2 0.5 -0.3 0.7 -0.2
Medication: Paracetamol 0.7 1.1 2.3 -0.6 -1.5 -0.8
Medication: Lisinopril 0.8 1.0 2.1 -0.9 1.5 0.3
Medication: Atorvastatin 1.3 1.7 4.0 -1.0 -2.0 -0.1
Illnesses of father: High blood pressure 0.8 1.0 3.0 1.7 0.2 0.2
Alcohol drinker status: Never 0.3 0.4 1.1 0.3 -0.3 1.0
Ever smoked 0.2 0.4 0.6 0.2 -0.7 -0.8
Basal metabolic rate 0.4 2.4 6.3 0.8 -0.5 2.5
Leg fat percentage (left) 1.8 6.4 17.3 -0.3 -4.2 1.4
Arm fat-free mass (left) 0.3 1.4 4.0 0.1 -0.2 2.0
Number of operations (self-reported) 0.9 1.3 2.3 -1.5 -1.3 -0.2
Average weekly beer plus cider intake 2.2 3.2 6.7 2.6 -1.7 0.1
Irritability 0.9 1.6 3.0 -1.2 -1.7 -0.3
Risk taking 0.2 0.3 0.6 -0.8 -0.4 -0.3
Ever had prostate specific antigen (PSA) test 1.7 2.0 5.8 -2.4 0.3 -0.2
Fractured/broken bones in last 5 years 1.7 2.2 3.2 -1.3 -1.3 -1.8
Age started oral contraceptive pill 1.4 1.8 4.4 -2.1 0.9 -0.5
Diastolic blood pressure, automated reading 0.0 0.1 0.2 -0.2 -0.5 0.3
Ever depressed for a whole week 0.8 1.0 2.2 -1.5 0.1 0.9
Unable to work because of sickness or disability 1.5 1.9 5.3 0.2 -2.3 -0.6
Commuting to job workplace: Cycle 0.4 0.5 1.1 1.1 0.4 -0.3
Myopia 0.3 0.4 1.3 -1.1 -0.2 0.2
Vascular/heart problems diagnosed by doctor 0.7 1.9 4.8 2.2 0.6 0.7
Cholesterol lowering medication 0.4 0.6 1.5 -1.2 0.2 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.3 -1.1 -0.1 0.8
Pain experienced in last month 2.7 4.4 11.9 0.3 3.4 -1.1
Supplements: Calcium 0.1 0.1 0.4 -0.6 -0.2 -0.1
Basal cell carcinoma (self-reported) 1.3 1.6 4.0 -0.6 2.0 0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.8 -0.1 -1.4 0.1
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.5 -1.6 0.5 -0.2
Heart disease (siblings) 0.5 0.6 1.5 0.3 -0.4 -1.2
Alcohol drinker status: Previous 3.6 4.1 7.7 -1.5 -2.8 -1.5
Pack years of smoking 1.3 1.9 3.6 -1.3 -1.9 -0.4
Impedance of whole body 0.1 0.4 0.7 0.8 0.7 -0.4
Leg fat mass (left) 1.5 5.7 13.0 0.5 -3.6 2.0
Arm predicted mass (left) 0.3 1.3 3.8 0.2 -0.4 1.9