Hub : Genes

CKLF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1400	0.0560	3.6e-03	0.002	NA	-0.004	NA	-0.003	2.1e-01	NA	8.4e-01	NA	6.4e-01
2	GTEx	Testis	0.3520	0.0910	5.0e-05	0.192	NA	0.149	NA	0.171	6.4e-09	NA	3.9e-07	NA	4.8e-08
3	NTR	Blood	0.0215	0.0083	9.9e-05	0.020	0.007	0.010	0.015	0.015	2.9e-07	0.0014	2.6e-04	6.5e-06	8.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.8	-1.4	-0.2	0.3
Bipolar Disorder or Schizophrenia	0.8	2.0	3.1	-1.6	0.6	1.8
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	-0.9	-1.5	0.7
Depression (Nagel 2018)	1.1	1.7	4.7	-0.6	-2.2	-0.1
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.1	0.4	2.2	-2.5
Neuroticism (Nagel 2018)	1.2	2.9	4.7	-1.8	-2.2	-0.8
Schizophrenia (2018)	0.9	1.8	3.6	-1.0	0.9	1.9
Schizophrenia vs Biploar Disorder	1.1	1.5	2.3	0.0	1.4	1.5
Worry (Nagel 2018)	1.4	2.9	4.4	-2.0	-0.5	-2.1
Alzheimer’s Disease (in mother)	0.8	1.0	2.5	0.4	-1.6	-0.5
Alzheimer’s Disease (in father)	3.3	3.6	5.4	-0.7	-2.2	2.3
Alzheimer’s Disease (including proxy)	2.2	3.2	7.6	-1.0	-2.8	1.0
Crohns Disease (2017)	0.1	0.1	0.2	-0.3	0.4	0.4
Irritable Bowel Disease (IBD)	0.4	0.9	1.3	-1.1	1.1	-0.4
Ulcerative Colitis (UC)	0.9	1.7	2.4	-1.5	1.3	-0.9
Major Depression (MDD)	0.1	0.1	0.3	0.1	-0.3	-0.5
Reaction Time	0.4	0.8	1.9	0.5	-0.5	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.3	-0.6	1.0	-1.1
Breast Cancer	0.9	2.3	5.5	-1.0	-2.3	-0.5
Ovarian Cancer	0.2	0.2	0.4	-0.2	-0.5	-0.6
Prostate Cancer	0.6	0.9	1.5	0.4	-1.2	-0.9
Age at First Birth	1.1	1.6	2.8	-0.9	1.7	-1.1
Bipolar Disorder (2011)	1.8	1.7	3.3	-0.3	-1.8	1.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.5	0.0	-0.3
Coronary Artery Disease (CAD)	0.1	0.2	0.4	-0.6	-0.1	0.3
Crohns Disease (2012)	0.5	0.8	1.4	0.9	1.2	-0.2
Mean Putamen Volume	0.4	0.4	0.9	-1.0	-0.4	0.4
Fasting Glucose	1.1	1.3	2.6	-0.7	-1.6	1.0
HbA1C	0.3	0.3	0.7	0.2	0.4	-0.8
HDL Cholesterol	2.2	3.6	6.2	-2.1	-2.5	0.2
LDL Cholesterol	0.9	1.4	2.1	-1.5	-1.4	-0.3
Lupus	0.2	0.4	1.0	1.0	-0.2	0.3
Neuroticism (2016)	0.5	0.8	1.9	-0.2	-0.7	1.4
Primary Biliary Cirrhosis	0.7	1.0	1.7	-1.3	-0.6	1.0
Rheumatoid Arthritis	1.6	2.2	2.5	1.4	-1.6	1.4
Schizophrenia (2014)	1.0	2.3	4.0	-1.1	1.2	2.0
Triglycerides	1.2	2.0	5.0	0.9	0.3	-2.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	1.6	-0.0	-0.1
Ulcerative Colitis	1.3	1.9	5.2	-0.6	2.3	0.1
Blood Eosinophil Count	0.2	1.6	4.6	-0.2	-0.2	2.1
Blood Platelet Count	0.1	0.8	1.3	0.3	-1.0	1.1
Blood Red Count	0.1	0.7	1.9	0.3	-0.1	1.4
Blood White Count	0.5	3.4	4.5	2.1	-2.1	1.2
Heel T-Score	1.2	9.8	27.2	-0.3	5.2	-1.4
BMI	0.5	2.6	5.1	1.1	-2.2	1.3
Height	0.3	5.7	13.8	0.8	1.6	3.7
Waist Hip Ratio (WHR)	0.6	2.8	8.2	2.9	0.3	0.1
Systolic Blood Pressure	0.2	1.2	2.6	-0.9	1.6	0.5
Smoking Status	0.2	0.6	1.6	0.1	-1.3	0.3
Allergy or Eczema	0.7	1.9	4.7	0.7	2.2	-0.7
Cardiovascular Disease	0.3	1.0	2.0	-1.4	-1.0	-0.1
Hypothyroidism (self reported)	1.1	2.4	6.4	-0.6	-2.5	-0.6
Respiratory disease	0.1	0.2	0.5	0.7	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.9	0.5	-1.7	-0.2
Lung FEV1/FVC ratio	1.0	5.0	6.6	2.3	1.8	2.6
Lung FVC	1.0	5.1	15.4	-0.1	0.1	-3.9
Neuroticism	0.4	1.1	1.9	-1.4	-1.0	-0.5
Chronotype (morning person)	1.4	3.2	5.2	-0.5	2.3	2.0
Hair Pigment	0.3	8.5	14.7	0.6	-3.8	-3.2
Tanning	0.1	0.9	1.7	0.5	1.3	0.9
Hand grip strength (left)	0.6	1.6	2.1	1.5	1.4	0.8
Number of treatments/medications taken	0.4	0.7	1.9	-0.4	-1.4	-0.0
Average weekly spirits intake	1.1	1.3	3.9	2.0	0.0	-0.2
Sensitivity / hurt feelings	1.5	2.6	5.8	-2.4	-1.4	0.1
Frequency of depressed mood in last 2 weeks	0.8	1.2	1.9	-1.4	-1.3	0.2
Hearing difficulty/problems: Yes	0.9	1.4	3.5	-1.9	-0.8	-0.1
Relative age of first facial hair	0.0	0.1	0.1	-0.3	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.6	-0.5	0.0
Ever used hormone-replacement therapy (HRT)	1.2	1.6	3.4	-1.9	-0.3	-1.1
Ever had hysterectomy (womb removed)	2.3	2.6	4.2	-0.6	-2.0	-1.8
Systolic blood pressure, automated reading	0.3	0.8	1.9	-1.4	0.7	0.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	1.8	-1.0	-1.2	-1.3
Angina	2.7	3.5	6.8	-1.4	-2.6	-1.4
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.3	-0.4	-0.7
Vitamin and mineral supplements	0.6	0.8	1.9	0.5	1.4	-0.6
Supplements: Zinc	0.5	0.5	0.8	0.9	-0.7	0.5
Medication: Co-codamol	2.1	2.5	4.7	-2.2	-0.1	-1.6
Medication: Metformin	0.2	0.2	0.7	-0.0	-0.9	-0.1
Diabetes (father)	3.5	4.4	10.6	1.0	-3.3	1.3
Diabetes (mother)	0.1	0.2	0.4	-0.2	-0.2	0.6
Severe depression (siblings)	0.4	0.4	0.6	0.7	-0.8	-0.4
Pack years adult smoking proportion	1.1	1.6	2.9	-1.3	-1.7	-0.4
Impedance of leg (right)	0.1	0.4	0.8	0.2	0.9	-0.6
Leg fat-free mass (left)	0.4	2.3	5.4	1.1	-0.5	2.3
Trunk fat percentage	1.2	4.8	8.6	1.0	-2.9	2.2
Hand grip strength (right)	0.3	0.8	1.4	1.2	1.0	0.2
Townsend deprivation index at recruitment	1.3	1.8	3.5	0.7	-1.9	-1.2
Current tobacco smoking	0.8	1.3	2.0	-0.5	-1.4	1.3
Average weekly fortified wine intake	0.3	0.4	0.6	-0.7	0.7	0.1
Maternal smoking around birth	0.3	0.5	1.1	-0.4	-0.3	1.1
Fed-up feelings	0.9	1.6	4.1	-0.9	-2.0	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	0.6	-1.8	-0.5
Relative age voice broke	0.3	0.5	1.3	-1.2	-0.2	0.4
Taking other prescription medications	1.1	1.7	4.8	-0.0	-2.2	-0.4
Age when periods started (menarche)	0.5	1.3	3.1	1.8	0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	8.1	-0.1	-2.8	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	11.1	-0.5	3.3	-1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.9	0.4	0.1	-2.0
Qualifications: CSEs or equivalent	1.5	2.0	4.8	2.2	0.2	-1.0
Serious illness, injury or assault to yourself	2.3	2.7	5.9	-1.5	0.3	-2.4
High blood pressure	0.4	1.2	2.9	-1.7	-0.4	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	0.7	0.9	-0.3
Multivitamins +/- minerals	0.5	0.6	1.0	0.1	-1.0	0.8
Stomach or abdominal pain in last month	1.5	1.9	3.5	-0.7	-1.3	1.9
Supplements: Glucosamine	0.3	0.4	0.8	-0.1	0.7	0.9
Diverticular disease/diverticulitis (self-reported)	4.5	5.4	6.6	-2.6	2.4	2.0
Medication: Atenolol	0.9	1.2	1.9	-1.3	-0.2	-1.4
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.4	-0.6	-0.8
Sitting height	0.5	3.5	6.7	1.9	2.6	0.3
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-0.8	1.4	-1.0
High blood pressure (mother)	0.3	0.4	0.9	1.0	0.5	-0.3
Body mass index (BMI)	1.0	4.2	9.8	0.3	-3.1	1.7
Impedance of leg (left)	0.0	0.1	0.2	-0.3	0.3	-0.5
Leg predicted mass (left)	0.4	2.2	4.9	1.1	-0.5	2.2
Trunk fat mass	1.2	5.2	7.3	1.1	-2.7	2.7
Waist circumference	0.9	3.2	7.3	0.6	-2.7	1.4
Number of incorrect matches in round	1.6	2.6	7.6	-2.8	0.0	0.4
Past tobacco smoking	0.4	0.8	2.3	-0.4	-0.0	1.5
Alcohol usually taken with meals	4.8	7.8	15.2	-3.9	2.9	0.1
Nervous feelings	0.7	1.3	2.5	-1.6	-0.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	-1.3	-0.9	0.3
Hearing difficulty/problems with background noise	0.5	0.8	2.1	-0.4	-1.5	0.3
Hair/balding pattern: Pattern 2	3.3	4.1	6.8	2.6	-1.0	2.1
Had menopause	1.1	1.3	3.4	-1.8	-0.3	-0.7
Had other major operations	1.4	1.7	2.7	-1.4	-0.8	1.6
Forced vital capacity (FVC)	0.5	1.8	2.8	1.7	1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	7.0	-1.1	2.7	-1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.7	-1.9	-0.5	0.0
Qualifications: None of the above	0.9	1.9	4.9	0.1	-2.2	0.8
Financial difficulties in last 2 years	1.3	1.8	5.3	0.0	-0.3	2.3
Mouth/teeth dental problems	0.4	0.7	1.3	1.1	-0.4	-0.7
Heart attack	0.7	0.8	2.5	-0.0	-1.6	-0.2
Allergy	0.1	0.1	0.2	-0.5	-0.4	0.2
Pain all over the body in last month	1.9	2.1	3.5	-1.9	-1.3	1.0
Diabetes (self-reported)	0.2	0.4	1.1	-1.0	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.4	-0.9	-0.6
Medication: Ramipril	0.9	1.1	2.2	1.0	-1.5	0.5
Medication: Simvastatin	0.7	1.1	2.7	-0.2	-1.7	-0.7
Fluid intelligence score	0.5	1.0	1.8	0.9	1.4	-0.7
Illnesses of siblings	1.1	1.6	2.7	1.4	0.3	1.7
Neuroticism score	0.8	1.7	3.3	-1.8	-1.3	-0.3
Weight	0.7	3.6	6.7	0.9	-1.8	2.6
Impedance of arm (right)	0.1	0.7	1.5	0.7	1.2	0.0
Arm fat percentage (right)	1.3	5.0	9.1	0.9	-3.0	2.2
Trunk fat-free mass	0.4	2.3	6.4	0.5	0.5	2.5
Hip circumference	1.1	4.6	9.2	-1.1	-3.0	1.8
Time employed in main current job	0.7	0.8	2.0	-0.5	-1.4	-0.2
Alcohol intake versus 10 years previously	1.7	2.6	4.3	2.1	1.3	-1.3
Father’s age at death	0.4	0.6	1.0	1.0	-0.5	0.7
Worrier / anxious feelings	0.8	1.5	3.0	-0.9	0.9	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.9	-1.3	-2.2	-0.8
Falls in the last year	1.8	2.4	4.0	0.1	-1.8	-2.0
Hair/balding pattern: Pattern 3	0.7	1.0	1.6	-1.2	0.3	-1.3
Number of live births	1.9	2.6	7.1	0.8	0.4	2.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.3	2.3	1.7	-0.4
Pulse rate	1.1	1.8	3.9	1.1	-2.0	-0.6
Happiness	1.3	1.6	4.5	-0.5	2.1	-0.2
Noisy workplace	0.5	0.6	0.8	-0.9	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.8	1.0	1.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.8	0.3	0.6	1.7
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	-0.8	-0.4	1.0
Asthma	0.2	0.4	0.8	0.9	-0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.1	1.3	-1.8	-0.7
Medication: Cholesterol lowering	1.0	1.6	4.2	0.1	-2.0	-0.7
Depression (self-reported)	1.0	1.2	1.7	1.1	-1.3	-0.7
Medication: Lansoprazole	0.7	0.8	1.6	-0.9	-1.3	0.2
Prospective memory result	0.6	0.7	1.5	-1.2	-0.5	0.6
Lung cancer (father)	0.8	0.9	1.7	-0.8	-1.3	0.7
Illnesses of mother	0.2	0.2	0.7	0.8	0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	2.6	1.6	1.6	-0.5
Pulse wave Arterial Stiffness index	1.7	1.9	4.9	-0.1	-0.9	2.2
Impedance of arm (left)	0.2	0.8	1.7	1.3	0.8	0.1
Arm fat mass (right)	1.2	4.8	6.9	0.7	-2.6	2.6
Trunk predicted mass	0.4	2.4	6.7	0.6	0.5	2.6
Standing height	0.4	4.4	7.2	1.0	2.7	2.2
Length of working week for main job	0.5	0.6	1.3	-0.1	-1.1	-0.6
Exposure to tobacco smoke at home	1.5	1.7	2.6	1.6	0.1	1.6
Breastfed as a baby	0.6	0.8	1.2	-0.6	0.9	1.1
Tense / ‘highly strung’	0.4	0.7	1.5	-1.2	-0.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.4	1.0	-1.2	0.7
Hair/balding pattern: Pattern 4	1.5	3.7	4.4	-1.9	2.1	-1.7
Birth weight of first child	0.3	0.6	1.5	1.2	0.2	0.4
Peak expiratory flow (PEF)	1.3	3.0	4.7	1.9	2.2	0.8
Pulse wave reflection index	0.9	1.1	1.7	-1.3	-0.6	1.1
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.3	-0.9	-1.8	0.6
Loud music exposure frequency	0.3	0.4	0.8	-0.9	0.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.7	1.1	1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-0.4	1.4	0.7
Blood clot in the leg (DVT)	0.6	0.8	2.3	-1.5	0.3	0.1
Medication: Paracetamol	0.4	0.6	1.0	-0.1	-1.0	-0.9
Headache pain in last month	0.9	1.6	3.7	-0.3	-1.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.1	0.9	0.6
Glaucoma (self-reported)	1.1	1.3	1.8	0.8	-1.4	-1.2
Gout (self-reported)	0.3	0.4	0.7	0.8	-0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.5	-0.6	-1.2	-0.8
Medication: Amlodipine	0.1	0.2	0.5	0.0	0.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.2	1.5	-1.8	-1.2
Birth weight	0.8	1.8	3.5	1.3	-0.6	1.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.9	-1.2	-0.7	1.4
High blood pressure (siblings)	1.3	1.8	4.0	-2.0	-0.1	-1.2
Forced vital capacity (FVC), Best measure	0.4	1.3	2.3	1.0	0.8	-1.5
Body fat percentage	1.5	5.8	12.0	0.7	-3.5	2.2
Leg fat percentage (right)	1.5	5.3	14.5	0.0	-3.8	1.2
Arm fat-free mass (right)	0.4	2.2	5.2	0.7	-0.9	2.3
Exposure to tobacco smoke outside home	0.5	0.7	1.4	0.7	-1.2	-0.5
Comparative body size at age 10	1.1	3.1	5.8	-1.7	0.8	2.4
Number of full brothers	0.4	0.5	0.8	0.2	-0.8	0.9
Worry too long after embarrassment	0.4	0.6	1.3	-1.2	-0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.8	0.1	0.1
Wheeze or whistling in the chest in last year	0.6	1.0	2.2	-0.8	-0.2	1.5
Number of children fathered	0.9	1.0	2.4	1.5	0.8	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	1.4	0.1	-0.8
Age at first live birth	0.8	1.5	2.1	-1.4	0.6	-1.4
Pulse wave peak to peak time	1.5	1.8	4.4	0.3	0.9	-2.1
Health satisfaction	1.5	1.9	4.4	-2.1	-0.6	1.0
Shortness of breath walking on level ground	0.6	0.7	1.3	-0.6	-1.2	0.5
Qualifications: College or University degree	0.2	0.5	0.8	-0.5	0.9	-0.6
Eye problems/disorders: None of the above	2.3	2.6	5.4	2.3	1.3	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.3	1.1	-0.0	-0.5
Emphysema/chronic bronchitis	1.7	1.9	2.7	-1.6	-1.6	0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	2.2	-0.2	1.5	0.6
Neck or shoulder pain in last month	1.2	1.7	2.9	-1.7	-1.3	0.7
Medication: Blood pressure	0.3	0.6	1.3	0.3	-0.6	-1.1
Angina (self-reported)	2.4	3.2	6.7	-1.1	-2.6	-1.3
Migraine (self-reported)	1.5	1.8	2.9	1.7	-1.4	-0.7
Medication: Ibuprofen	1.8	2.2	6.0	0.7	-2.5	-0.1
Medication: Allopurinol	0.3	0.4	0.7	0.7	-0.8	0.0
Medication: Omeprazole	1.6	1.9	3.1	-1.8	-0.2	1.6
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.9	0.0	0.5
Mean time to correctly identify matches	0.3	0.6	1.2	-0.1	-0.7	-1.1
Heart disease (mother)	0.4	0.4	1.3	-1.1	-0.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.4	0.7	0.6	1.5
Whole body fat mass	1.4	5.7	9.5	0.8	-3.1	2.6
Leg fat mass (right)	1.3	5.1	11.4	0.7	-3.4	1.9
Arm predicted mass (right)	0.4	2.0	4.9	0.8	-0.8	2.2
Pulse rate, automated reading	1.8	5.8	15.3	1.0	-3.9	-1.0
Alcohol intake frequency.	0.5	1.1	2.5	-1.6	-0.9	-0.4
Comparative height size at age 10	0.3	1.5	2.6	-0.6	1.6	1.3
Number of full sisters	0.7	0.9	2.5	1.6	-0.2	-0.1
Suffer from ‘nerves’	0.5	0.8	2.0	-1.4	-0.6	-0.2
Overall health rating	1.2	2.6	6.9	-1.0	-2.6	0.1
Chest pain or discomfort	1.9	2.7	3.9	-1.3	-1.6	-2.0
Had major operations	0.9	1.0	2.7	-0.6	-1.6	-0.1
Age at last live birth	0.3	0.5	1.1	-1.1	-0.5	0.2
Family relationship satisfaction	2.4	2.9	8.4	-0.3	2.9	-0.5
Leg pain on walking	1.2	1.4	3.1	-1.1	0.1	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	-1.1	1.3	0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.6	-1.6	-0.6	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	0.7	-0.5	-1.0
Medication: Aspirin	0.7	0.9	1.3	-1.2	-1.1	0.3
Supplements: Vitamin C	0.7	0.8	2.1	-1.5	-0.3	-0.4
Knee pain experienced in last month	0.6	1.0	1.8	-0.4	-1.3	1.0
Hypertension (Self-reported)	0.5	1.3	3.0	-1.7	-0.5	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	-0.1	0.4	0.9
Illnesses of father: Heart disease	0.3	0.4	0.6	0.6	-0.5	0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.6	0.4	0.3
Smoking status: Previous	0.6	0.9	2.2	0.7	0.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.4	0.6	-0.3	1.2
Whole body fat-free mass	0.4	2.1	5.7	0.7	-0.1	2.4
Leg fat-free mass (right)	0.4	2.0	5.0	0.8	-0.6	2.2
Arm fat percentage (left)	1.6	6.4	11.5	1.3	-3.4	2.4
Average weekly red wine intake	2.9	4.3	9.2	-1.7	0.8	3.0
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.1	-0.8	0.7	-1.4
Mood swings	0.4	0.7	2.0	-0.3	-0.1	1.4
Loneliness, isolation	0.5	0.7	1.6	-0.7	0.2	1.3
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.6	-0.3	-0.1
Ever had bowel cancer screening	0.9	1.0	2.0	-1.0	1.4	-0.4
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.2	-0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.4	-1.2	0.5	0.3
Friendships satisfaction	0.5	0.6	1.5	0.3	1.2	0.3
Qualifications: nursing, teaching	1.0	1.5	4.6	0.0	0.0	-2.2
Commuting to job workplace: Walk	0.6	0.6	1.7	1.3	0.5	-0.0
Eye problems/disorders: Cataract	1.9	2.2	3.2	-1.8	-1.3	1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	-1.1	0.9	0.4
Medication for cholesterol	0.6	1.0	2.6	1.6	-0.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-1.4	-0.7	-0.6
Back pain experienced in last month	1.2	1.7	4.8	-0.6	-2.2	0.2
Mineral and other dietary supplements	0.1	0.1	0.3	0.2	-0.3	-0.5
Breast cancer (self-reported)	0.7	0.8	1.6	-1.3	0.2	-0.8
Asthma (self-reported)	0.2	0.4	0.6	0.8	-0.8	-0.1
Osteoporosis (self-reported)	1.2	1.5	4.5	-2.1	-0.3	0.3
Osteoarthritis (self-reported)	0.4	0.6	1.3	-1.1	-0.6	-0.1
Medication: Aspirin	0.8	1.1	2.1	-1.4	-1.0	0.5
Medication: Gliclazide	0.3	0.4	0.6	-0.3	0.6	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.6	0.5	-0.4
Smoking status: Current	0.8	1.2	2.7	-0.4	-1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	7.4	0.9	2.7	-1.1
Whole body water mass	0.4	2.1	5.7	0.7	-0.1	2.4
Leg predicted mass (right)	0.4	2.0	5.0	0.9	-0.6	2.2
Arm fat mass (left)	1.3	5.4	8.1	1.2	-2.8	2.6
Number of self-reported non-cancer illnesses	0.8	1.4	2.5	-1.1	-1.6	-0.7
Average weekly champagne plus white wine intake	3.3	4.5	12.6	-3.5	0.5	0.8
Miserableness	0.7	1.2	1.7	-1.0	-1.3	1.0
Guilty feelings	0.8	1.2	1.9	-1.0	-0.8	1.4
Wears glasses or contact lenses	2.0	2.3	3.4	-1.9	-1.8	-0.5
Ever taken oral contraceptive pill	0.5	0.5	0.6	-0.8	0.5	0.8
Hearing aid user	0.7	0.8	1.7	-0.7	-1.3	0.4
Mother’s age at death	0.9	1.2	2.2	-1.0	1.5	-0.6
Financial situation satisfaction	0.6	0.7	2.0	0.3	1.4	0.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.8	-0.6	1.2	2.2
Commuting to job workplace: Public transport	1.5	1.7	3.4	1.2	1.9	0.6
Eye problems/disorders: Glaucoma	1.8	2.1	4.2	0.4	-1.4	-2.1
Medication: Blood pressure	0.5	1.0	2.2	-1.5	0.9	0.4
Pain type(s) experienced in last month: Hip pain	1.1	1.3	3.8	-0.4	-1.9	0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	-0.1	0.7	1.6
High cholesterol (Self-reported)	0.4	0.7	1.8	0.1	-1.3	-0.5
Medication: Bendroflumethiazide	0.2	0.2	0.5	-0.3	0.7	-0.2
Medication: Paracetamol	0.7	1.1	2.3	-0.6	-1.5	-0.8
Medication: Lisinopril	0.8	1.0	2.1	-0.9	1.5	0.3
Medication: Atorvastatin	1.3	1.7	4.0	-1.0	-2.0	-0.1
Illnesses of father: High blood pressure	0.8	1.0	3.0	1.7	0.2	0.2
Alcohol drinker status: Never	0.3	0.4	1.1	0.3	-0.3	1.0
Ever smoked	0.2	0.4	0.6	0.2	-0.7	-0.8
Basal metabolic rate	0.4	2.4	6.3	0.8	-0.5	2.5
Leg fat percentage (left)	1.8	6.4	17.3	-0.3	-4.2	1.4
Arm fat-free mass (left)	0.3	1.4	4.0	0.1	-0.2	2.0
Number of operations (self-reported)	0.9	1.3	2.3	-1.5	-1.3	-0.2
Average weekly beer plus cider intake	2.2	3.2	6.7	2.6	-1.7	0.1
Irritability	0.9	1.6	3.0	-1.2	-1.7	-0.3
Risk taking	0.2	0.3	0.6	-0.8	-0.4	-0.3
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.8	-2.4	0.3	-0.2
Fractured/broken bones in last 5 years	1.7	2.2	3.2	-1.3	-1.3	-1.8
Age started oral contraceptive pill	1.4	1.8	4.4	-2.1	0.9	-0.5
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.2	-0.5	0.3
Ever depressed for a whole week	0.8	1.0	2.2	-1.5	0.1	0.9
Unable to work because of sickness or disability	1.5	1.9	5.3	0.2	-2.3	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.1	1.1	0.4	-0.3
Myopia	0.3	0.4	1.3	-1.1	-0.2	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.8	2.2	0.6	0.7
Cholesterol lowering medication	0.4	0.6	1.5	-1.2	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.3	-1.1	-0.1	0.8
Pain experienced in last month	2.7	4.4	11.9	0.3	3.4	-1.1
Supplements: Calcium	0.1	0.1	0.4	-0.6	-0.2	-0.1
Basal cell carcinoma (self-reported)	1.3	1.6	4.0	-0.6	2.0	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	-0.1	-1.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-1.6	0.5	-0.2
Heart disease (siblings)	0.5	0.6	1.5	0.3	-0.4	-1.2
Alcohol drinker status: Previous	3.6	4.1	7.7	-1.5	-2.8	-1.5
Pack years of smoking	1.3	1.9	3.6	-1.3	-1.9	-0.4
Impedance of whole body	0.1	0.4	0.7	0.8	0.7	-0.4
Leg fat mass (left)	1.5	5.7	13.0	0.5	-3.6	2.0
Arm predicted mass (left)	0.3	1.3	3.8	0.2	-0.4	1.9