Hub : Genes

CLCN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0190	0.00720	0.036	0.015	0.025	0.019	0.024	3.0e-05	0.00580	0.00041	0.0021	5.1e-04
2	GTEx	Colon Transverse	0.1630	0.0550	0.00014	0.121	NA	0.077	NA	0.075	2.4e-06	NA	0.00016	NA	1.9e-04
3	NTR	Blood	0.0168	0.0081	0.00500	0.015	0.005	0.011	0.006	0.012	1.1e-05	0.00970	0.00012	0.0027	7.5e-05
4	TCGA	Colon Adenocarcinoma	0.0870	0.0570	0.00750	0.027	0.025	0.032	NA	0.041	1.1e-02	0.01400	0.00600	NA	2.1e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0365	0.0169	0.00074	0.029	0.009	0.023	NA	0.016	2.7e-04	0.02700	0.00100	NA	5.1e-03
6	TCGA	Thyroid Carcinoma	0.0670	0.0340	0.00014	0.026	0.035	0.018	NA	0.030	1.4e-03	0.00021	0.00580	NA	5.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.4	0.7	0.3	0.7	-0.6	0.8	0.8	0.5
Bipolar Disorder or Schizophrenia	6.3	15.3	20.4	4.2	3.8	-4.1	4.0	4.5	2.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.7	-0.9	-0.4	1.9	-0.3	-1.7	0.8
Depression (Nagel 2018)	0.4	0.6	1.3	0.5	0.7	-1.0	1.1	0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.7	-0.9	-1.0	-0.2	-1.7	-0.5	-0.4
Neuroticism (Nagel 2018)	0.2	0.5	1.4	0.2	0.3	0.7	1.2	-0.6	0.5
Schizophrenia (2018)	9.9	20.6	27.1	5.2	4.3	-4.9	4.5	5.1	2.8
Schizophrenia vs Biploar Disorder	3.6	4.7	5.9	2.4	2.1	-2.2	1.9	2.2	2.2
Worry (Nagel 2018)	0.3	0.7	3.4	0.3	-0.0	0.3	1.8	-0.5	-0.7
Alzheimer’s Disease (in mother)	0.0	0.1	0.2	-0.4	-0.1	0.2	0.2	-0.2	-0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.8	1.2	0.8	-0.4	1.7	1.0	0.7
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.1	-0.1	0.6	0.8	-0.2	0.4
Crohns Disease (2017)	0.4	0.8	2.0	-0.5	-0.5	1.4	0.6	-1.1	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	0.0	-0.0	0.8	1.3	-0.7	-1.1
Ulcerative Colitis (UC)	0.2	0.3	1.1	-0.0	-0.1	0.4	0.7	-0.4	-1.0
Major Depression (MDD)	2.5	3.0	4.5	2.1	1.9	-1.1	2.1	1.0	1.8
Reaction Time	0.8	1.5	2.4	1.6	1.2	-1.2	1.0	1.2	1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	-0.2	-0.5	-0.8	-1.1	0.2	-0.3
Breast Cancer	0.0	0.1	0.3	-0.0	-0.5	-0.1	0.1	-0.1	-0.6
Ovarian Cancer	0.8	1.0	1.5	1.2	1.1	-1.1	0.8	0.9	0.9
Prostate Cancer	0.4	0.6	1.8	-0.5	0.5	0.4	-1.3	-0.1	1.1
Age at First Birth	0.3	0.4	0.9	0.6	0.6	-1.0	0.1	0.9	0.4
Bipolar Disorder (2011)	1.4	1.3	3.8	0.8	1.4	-0.8	0.0	1.0	1.9
Body Mass Index (BMI) (2010)	1.5	2.1	4.8	-1.4	-1.3	2.2	-0.7	-1.9	0.5
Coronary Artery Disease (CAD)	0.5	0.5	1.1	-0.7	-0.7	0.7	-1.1	-0.6	-0.5
Crohns Disease (2012)	0.2	0.3	0.8	0.0	-0.4	0.5	0.9	-0.2	-0.7
Mean Putamen Volume	0.4	0.5	2.3	-0.1	0.6	-0.0	-0.5	0.3	1.5
Fasting Glucose	0.5	0.6	1.8	0.3	-0.1	1.3	1.1	-0.5	0.3
HbA1C	0.2	0.2	0.4	0.5	0.3	-0.2	0.4	0.6	0.6
HDL Cholesterol	0.4	0.6	1.1	-0.7	-0.2	0.9	-1.1	-0.7	1.0
LDL Cholesterol	0.1	0.2	0.5	-0.3	-0.1	0.7	-0.1	-0.7	0.6
Lupus	3.2	4.8	7.0	2.5	1.5	-2.5	2.5	2.6	0.9
Neuroticism (2016)	0.6	0.9	2.3	0.7	1.1	-0.6	0.6	0.6	1.5
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.8	0.3	-0.4	0.8	1.0	-0.3
Rheumatoid Arthritis	0.4	0.5	1.5	-0.6	-0.6	0.6	-1.2	-0.6	-0.6
Schizophrenia (2014)	10.4	22.9	30.3	5.5	4.7	-5.0	4.4	5.4	3.4
Triglycerides	0.1	0.1	0.3	0.5	-0.3	-0.5	0.1	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.8	-1.0	-1.3	0.4	-0.8	-0.8	-1.4
Ulcerative Colitis	0.1	0.2	0.6	0.5	0.2	-0.1	0.8	-0.0	-0.4
Blood Eosinophil Count	0.2	1.6	3.0	-1.2	-1.2	1.6	-1.0	-1.7	-0.8
Blood Platelet Count	0.6	6.8	13.5	-2.4	-2.6	3.7	-1.2	-3.7	-0.4
Blood Red Count	0.0	0.2	0.4	-0.1	-0.3	0.6	-0.2	-0.4	-0.6
Blood White Count	0.4	2.7	7.1	-1.1	-2.0	0.7	-0.3	-1.9	-2.7
Heel T-Score	0.4	2.9	6.0	-2.2	-1.1	2.5	-1.2	-1.7	-1.1
BMI	0.7	4.1	6.5	-2.5	-2.4	1.9	-2.1	-1.9	-0.7
Height	0.1	1.2	5.4	-0.6	-0.2	-0.9	-2.3	0.4	0.5
Waist Hip Ratio (WHR)	0.1	0.4	0.8	-0.3	-0.9	0.3	-0.0	-0.9	-0.7
Systolic Blood Pressure	0.5	2.4	6.8	1.9	1.4	-0.9	2.6	1.2	0.5
Smoking Status	0.0	0.1	0.4	-0.2	0.1	-0.6	-0.2	-0.1	-0.4
Allergy or Eczema	0.1	0.3	0.6	-0.5	-0.7	0.5	0.3	-0.8	-0.2
Cardiovascular Disease	0.2	0.6	1.2	-0.7	-0.8	0.7	0.2	-0.7	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.7	-0.6	0.7	-1.0	-0.0	-0.8
Respiratory disease	0.1	0.2	0.6	0.5	-0.2	-0.8	0.1	0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.2	-1.1	0.1	0.2	-0.7	0.1	0.1
Lung FEV1/FVC ratio	1.1	5.4	13.0	-3.2	-1.5	1.7	-3.6	-2.0	-0.4
Lung FVC	0.0	0.2	0.5	-0.4	0.7	0.3	0.2	-0.3	0.0
Neuroticism	0.2	0.4	1.6	0.1	0.1	0.6	1.3	-0.6	0.2
Chronotype (morning person)	0.1	0.2	0.9	-0.3	-0.5	-0.2	0.0	0.0	-0.9
Hair Pigment	0.1	2.2	4.8	-1.2	-1.3	2.2	0.5	-1.7	-1.3
Tanning	0.0	0.5	1.1	-0.4	-1.1	0.7	0.7	-0.5	-0.8
Hand grip strength (left)	1.2	3.2	5.2	1.9	1.4	-2.2	1.8	2.3	0.0
Number of treatments/medications taken	0.2	0.3	0.7	-0.6	-0.2	0.8	0.1	-0.6	-0.4
Average weekly spirits intake	3.1	3.8	6.2	-2.5	-1.9	1.4	-1.7	-1.9	-2.1
Sensitivity / hurt feelings	0.5	0.8	2.1	0.2	-0.5	1.0	1.5	-1.0	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.0	-0.1	0.1	0.6	-0.5	-0.6
Hearing difficulty/problems: Yes	1.5	2.3	5.6	1.1	1.6	-2.4	1.1	1.8	0.6
Relative age of first facial hair	0.6	1.2	2.0	0.8	1.2	-1.3	-0.5	1.4	1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.4	-0.3	-0.5	-0.8	0.3	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	0.7	0.6	-0.9	1.1	0.1	-0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.5	-0.5	0.1	-0.5	-0.2	0.6
Systolic blood pressure, automated reading	0.7	2.0	3.9	1.3	1.5	-1.5	2.0	1.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.6	-0.1	-0.0	0.7	-0.1	-0.1	0.5
Angina	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.4	-0.5	-0.0
Medication for hormone replacement therapy	0.5	0.6	1.7	0.3	-0.3	0.3	1.2	-0.2	-1.3
Vitamin and mineral supplements	0.1	0.1	0.5	-0.7	-0.1	0.3	0.2	-0.2	-0.0
Supplements: Zinc	4.2	4.6	7.3	2.4	2.2	-1.9	2.7	2.4	0.7
Medication: Co-codamol	0.1	0.2	0.5	0.5	0.1	-0.0	0.7	-0.3	0.4
Medication: Metformin	2.2	3.2	5.9	-2.4	-1.6	1.9	-1.8	-1.7	-0.9
Diabetes (father)	0.4	0.5	1.6	0.1	0.6	-1.3	-0.2	1.0	0.5
Diabetes (mother)	0.3	0.4	0.9	0.5	0.7	-0.4	0.3	0.5	0.9
Severe depression (siblings)	1.5	1.7	3.9	2.0	1.2	-1.0	1.6	0.9	0.6
Pack years adult smoking proportion	0.3	0.5	0.8	-0.8	-0.9	0.3	-0.1	-0.8	-0.8
Impedance of leg (right)	0.2	1.1	4.3	0.9	-0.1	-0.4	2.1	0.6	-1.0
Leg fat-free mass (left)	0.4	1.9	6.4	-1.5	-1.1	0.8	-2.5	-0.8	0.2
Trunk fat percentage	0.4	1.5	2.3	-1.5	-1.1	1.4	-1.3	-1.1	0.7
Hand grip strength (right)	0.3	0.8	1.3	1.0	0.7	-1.0	1.1	1.0	-0.4
Townsend deprivation index at recruitment	1.2	1.7	2.8	1.4	0.6	-1.7	1.6	1.3	-0.7
Current tobacco smoking	0.4	0.7	1.3	-0.9	-0.6	1.0	-0.5	-1.1	-0.9
Average weekly fortified wine intake	0.1	0.1	0.5	0.1	0.1	-0.4	-0.7	0.2	-0.4
Maternal smoking around birth	0.2	0.3	0.5	-0.1	0.6	-0.7	-0.5	0.7	0.4
Fed-up feelings	0.8	1.4	2.6	-1.6	-1.4	0.7	-1.2	-1.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	0.9	0.6	-1.3	0.6	0.9	0.1
Relative age voice broke	0.5	0.8	2.9	-0.2	0.6	-0.0	-1.3	0.3	1.7
Taking other prescription medications	0.3	0.5	1.2	-0.7	-0.3	1.1	-0.5	-1.0	-0.2
Age when periods started (menarche)	0.3	0.8	1.8	-1.2	-0.4	0.7	-1.3	-0.8	0.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	2.4	-1.1	-1.6	1.4	-0.5	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	2.9	-1.5	-1.0	1.7	-1.4	-1.4	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	-0.6	-0.2	-0.0	-1.2	-0.2	-0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.3	-0.2	-0.5	0.8	-1.1	-0.3	0.5
Serious illness, injury or assault to yourself	0.7	0.9	2.0	0.6	0.1	-1.3	0.4	1.0	-1.4
High blood pressure	0.5	1.5	5.9	-0.7	-1.2	-0.1	1.1	-0.3	-2.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	-0.7	-0.9	0.6	-0.1	-0.9	-0.6
Multivitamins +/- minerals	1.1	1.4	2.8	-0.9	-1.1	0.7	-1.7	-1.4	-1.1
Stomach or abdominal pain in last month	2.1	2.6	6.4	2.1	1.1	-1.2	2.5	1.5	-0.1
Supplements: Glucosamine	1.2	1.6	6.4	-1.3	-0.1	0.3	-2.5	-0.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	1.0	0.3	-0.2	0.9	0.5	-0.2
Medication: Atenolol	0.4	0.5	1.4	-0.3	-0.8	0.3	-0.4	-0.6	-1.2
Medication: Levothyroxine sodium	0.9	1.5	3.1	-1.4	-0.8	1.5	-1.8	-0.9	-0.1
Sitting height	0.1	0.6	1.0	0.8	0.5	-0.7	-0.3	1.0	0.9
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.2	0.3	-0.1	0.5	0.1	-0.4
High blood pressure (mother)	1.3	1.8	5.1	-1.7	-1.2	0.2	-2.3	-1.0	-0.5
Body mass index (BMI)	0.8	3.3	5.0	-2.2	-1.8	1.9	-2.0	-1.9	-0.1
Impedance of leg (left)	0.2	1.2	4.3	1.1	0.2	-0.6	2.1	0.9	-0.8
Leg predicted mass (left)	0.3	1.8	6.1	-1.5	-1.1	0.8	-2.5	-0.8	0.2
Trunk fat mass	0.5	2.1	3.8	-1.9	-1.4	1.3	-2.0	-1.2	0.5
Waist circumference	0.9	3.4	5.7	-2.4	-2.0	1.4	-2.3	-1.8	-0.3
Number of incorrect matches in round	3.2	5.3	6.8	2.4	2.2	-2.3	2.6	2.5	1.6
Past tobacco smoking	0.2	0.4	1.4	-0.1	-0.5	1.2	-0.1	-0.7	0.0
Alcohol usually taken with meals	0.9	1.4	2.0	1.1	1.1	-1.4	1.0	1.4	1.1
Nervous feelings	1.1	2.0	4.8	1.4	1.1	-1.3	2.2	1.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	0.9	0.7	-1.1	1.3	1.0	-0.2
Hearing difficulty/problems with background noise	6.2	9.9	14.5	3.0	3.8	-3.4	3.2	3.1	2.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.8	-0.2	-0.1	0.9	0.4	-0.7
Had menopause	1.2	1.5	2.5	0.9	1.3	-1.6	1.3	1.3	0.6
Had other major operations	0.6	0.8	2.1	0.5	-0.2	-0.7	1.3	0.0	-1.4
Forced vital capacity (FVC)	0.3	1.1	2.7	-1.0	-0.9	0.7	-1.6	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	3.6	-1.9	-1.4	1.8	-1.6	-1.8	-1.4
Ever unenthusiastic/disinterested for a whole week	4.1	5.0	9.0	3.0	2.5	-2.2	1.7	2.0	1.7
Qualifications: None of the above	0.1	0.2	0.6	-0.5	0.3	0.3	-0.4	-0.8	0.3
Financial difficulties in last 2 years	1.3	1.8	3.3	-0.8	-1.6	1.6	-0.3	-1.8	-1.3
Mouth/teeth dental problems	0.1	0.1	0.4	-0.0	-0.0	0.4	-0.6	-0.3	0.2
Heart attack	1.8	2.4	3.5	-1.9	-1.4	1.8	-0.9	-1.8	-1.1
Allergy	0.1	0.2	0.9	-0.6	-0.3	0.3	-0.9	-0.3	0.1
Pain all over the body in last month	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.4	0.2	-0.3
Diabetes (self-reported)	0.1	0.2	0.5	-0.2	0.3	-0.5	0.4	0.7	0.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.2	-0.6	-0.9	1.5	-0.2	-1.4	-0.8
Medication: Ramipril	1.1	1.5	3.5	-1.2	-1.2	1.9	0.3	-1.4	-0.5
Medication: Simvastatin	0.2	0.2	0.7	0.3	0.4	0.1	0.6	0.2	0.8
Fluid intelligence score	0.2	0.4	0.9	-0.4	-0.1	-0.8	-1.0	0.3	-0.6
Illnesses of siblings	0.4	0.5	1.0	0.5	0.6	-0.9	-0.1	0.9	1.0
Neuroticism score	0.2	0.3	1.1	0.1	-0.0	0.6	1.0	-0.7	-0.2
Weight	0.6	3.2	6.8	-2.2	-1.8	1.5	-2.6	-1.5	0.1
Impedance of arm (right)	0.7	3.4	4.9	2.1	1.9	-0.8	2.1	1.6	2.2
Arm fat percentage (right)	0.4	1.5	2.4	-1.4	-0.9	1.5	-1.2	-1.2	1.1
Trunk fat-free mass	0.4	2.5	7.5	-1.7	-1.6	0.7	-2.7	-1.1	-0.8
Hip circumference	1.0	4.3	7.5	-2.5	-2.3	1.7	-2.7	-1.9	-0.3
Time employed in main current job	0.1	0.2	0.3	-0.1	0.4	0.6	-0.2	-0.3	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.4	0.2	-0.3	-0.5	0.8	0.7
Father’s age at death	0.2	0.3	0.7	-0.5	-0.1	0.8	-0.0	-0.8	-0.5
Worrier / anxious feelings	0.7	1.4	3.7	0.0	-1.1	0.9	1.4	-0.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.8	2.2	1.2	-1.2	1.9	1.0	0.2
Falls in the last year	1.7	2.3	4.9	-1.7	-1.8	0.2	-2.2	-1.0	-1.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	0.2	-0.3	0.2	0.1	-0.1
Number of live births	1.6	2.3	6.0	1.4	1.7	-1.4	2.5	0.7	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.2	-1.7	-1.2	1.1	-2.0	-1.2	-1.0
Pulse rate	0.3	0.5	0.9	0.3	-0.6	1.0	0.7	-0.5	-0.8
Happiness	2.1	2.6	6.9	2.0	1.2	-1.1	2.6	1.4	0.2
Noisy workplace	0.5	0.7	1.0	0.5	0.9	-0.6	0.9	0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.3	1.2	1.4	-0.8	0.9	1.1	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.8	1.0	0.7	-2.2	1.3	1.5	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.0	-0.8	-0.5	0.3	-1.0	-0.7	0.2
Asthma	0.1	0.2	0.4	0.6	0.2	-0.7	0.3	0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	-0.4	-0.9	0.3	-0.5	-0.2	-0.9
Medication: Cholesterol lowering	0.3	0.4	1.4	-0.2	0.6	0.6	0.7	0.1	1.2
Depression (self-reported)	0.5	0.7	1.1	-0.5	-0.7	1.0	0.4	-1.0	-1.1
Medication: Lansoprazole	1.7	1.9	4.5	1.6	1.5	-1.2	2.1	1.0	-0.1
Prospective memory result	1.0	1.3	2.9	-0.6	-1.2	1.7	0.3	-1.6	-0.5
Lung cancer (father)	0.3	0.4	0.9	0.8	0.2	-0.5	1.0	0.1	-0.8
Illnesses of mother	0.7	0.8	2.7	1.2	0.1	-0.4	1.6	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.4	-0.6	-0.2	0.1	-1.2	-0.1	-0.5
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	-0.8	-0.4	1.4	-1.5	-1.6	0.3
Impedance of arm (left)	0.5	2.2	3.0	1.7	1.4	-1.0	1.6	1.5	1.6
Arm fat mass (right)	0.6	2.6	4.0	-1.9	-1.5	1.7	-2.0	-1.5	0.4
Trunk predicted mass	0.5	2.7	7.7	-1.7	-1.6	0.8	-2.8	-1.2	-0.9
Standing height	0.1	0.6	2.2	-0.0	-0.1	-0.9	-1.5	0.7	0.3
Length of working week for main job	2.2	2.4	5.2	-1.7	-1.9	0.2	-2.3	-1.0	-1.3
Exposure to tobacco smoke at home	0.5	0.5	1.3	-0.8	-0.5	-0.2	-1.1	-0.1	-1.0
Breastfed as a baby	0.1	0.2	0.7	-0.3	-0.3	0.3	-0.9	-0.1	-0.1
Tense / ‘highly strung’	1.4	2.4	6.0	1.7	1.2	-1.5	2.4	1.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.3	1.1	0.7	-0.2	1.5	0.2	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.8	-0.6	0.2	-0.5	-0.1	0.2
Birth weight of first child	0.3	0.5	0.8	-0.9	-0.2	0.8	-0.8	-0.9	-0.0
Peak expiratory flow (PEF)	0.4	0.9	2.8	-1.3	-0.5	-0.3	-1.7	-0.0	-0.8
Pulse wave reflection index	0.5	0.6	2.3	0.1	0.5	0.1	-1.0	-0.3	1.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	0.8	0.6	-0.4	-0.2	0.2	1.4
Loud music exposure frequency	0.1	0.1	0.4	-0.1	0.3	-0.6	0.2	0.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.1	-0.2	-0.2	0.4	0.2	0.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.5	-1.3	-1.6	1.5	-0.4	-1.5	-1.4
Blood clot in the leg (DVT)	1.1	1.4	2.2	-0.8	-1.4	1.4	-0.3	-1.1	-1.5
Medication: Paracetamol	0.6	1.0	2.7	-0.5	-0.7	1.6	0.6	-1.1	-0.9
Headache pain in last month	0.3	0.5	1.5	0.9	0.5	0.2	1.2	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.3	-0.3	-0.7	-0.2	0.3	-1.0
Glaucoma (self-reported)	1.9	2.3	4.0	1.2	1.6	-1.6	2.0	1.8	0.2
Gout (self-reported)	0.5	0.7	1.8	-1.0	-0.3	1.4	-0.1	-0.9	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	-0.3	-0.3	0.9	-1.2	-0.1	0.2
Medication: Amlodipine	0.9	1.3	2.7	0.8	1.0	-1.6	0.9	1.4	0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	-1.0	-0.6	1.3	-0.8	-1.0	-0.1
Birth weight	0.3	0.5	1.1	-0.8	-0.1	1.0	-0.7	-1.0	0.4
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.5	1.3	1.9	-0.6	2.1	1.1	1.6
High blood pressure (siblings)	0.3	0.5	0.7	-0.8	-0.8	0.6	-0.4	-0.8	-0.6
Forced vital capacity (FVC), Best measure	0.0	0.1	0.5	0.1	0.2	-0.0	-0.7	0.1	0.0
Body fat percentage	0.4	1.6	2.6	-1.6	-1.2	1.6	-1.2	-1.3	0.5
Leg fat percentage (right)	0.6	2.2	3.4	-1.9	-1.7	1.8	-0.9	-1.6	-0.3
Arm fat-free mass (right)	0.5	2.6	7.1	-1.8	-1.7	0.6	-2.7	-1.1	-0.9
Exposure to tobacco smoke outside home	1.2	1.6	4.6	0.8	1.1	-2.1	0.3	1.5	0.8
Comparative body size at age 10	0.5	1.4	3.2	-1.8	-1.0	0.9	-1.6	-0.9	-0.3
Number of full brothers	0.2	0.2	0.7	0.2	-0.3	-0.0	0.7	-0.3	-0.8
Worry too long after embarrassment	0.4	0.6	2.0	0.4	0.5	-1.4	0.7	0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.0	1.7	1.7	-1.2	1.4	1.7	1.3
Wheeze or whistling in the chest in last year	1.5	2.6	4.6	2.1	1.6	-1.3	2.0	1.7	0.0
Number of children fathered	1.2	1.3	2.3	-1.4	-0.4	1.5	-1.2	-1.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.1	0.8	0.8	-0.7	0.8	0.7	1.0
Age at first live birth	0.2	0.3	0.5	0.1	0.6	-0.5	-0.6	0.7	0.6
Pulse wave peak to peak time	1.0	1.2	2.5	0.7	0.3	-1.4	1.4	1.6	-0.4
Health satisfaction	0.6	0.8	1.7	0.9	1.2	-0.3	1.3	0.7	0.7
Shortness of breath walking on level ground	0.0	0.0	0.2	0.4	-0.1	0.2	0.2	-0.1	0.2
Qualifications: College or University degree	0.8	2.7	4.7	1.7	1.8	-2.2	1.5	1.6	0.6
Eye problems/disorders: None of the above	1.0	1.1	1.7	-1.3	-1.2	0.8	-1.1	-1.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.6	0.2	-0.6	-0.4	0.4	0.3
Emphysema/chronic bronchitis	1.0	1.2	2.4	1.6	1.1	-0.8	0.6	1.0	1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	3.1	-0.8	-0.6	-0.1	-1.8	-0.5	-0.3
Neck or shoulder pain in last month	0.6	0.9	1.4	1.1	1.2	-0.8	0.6	0.8	1.1
Medication: Blood pressure	0.4	0.7	1.7	-0.9	-0.5	1.3	0.5	-1.1	-0.1
Angina (self-reported)	0.2	0.2	0.5	-0.4	-0.4	0.4	-0.7	-0.7	-0.1
Migraine (self-reported)	0.4	0.5	2.0	0.0	-0.4	-0.1	1.4	0.1	-1.0
Medication: Ibuprofen	0.8	0.9	1.7	-1.0	-1.2	0.8	-1.3	-0.8	-0.3
Medication: Allopurinol	0.2	0.2	0.6	-0.0	0.8	0.3	0.5	-0.2	0.5
Medication: Omeprazole	0.3	0.3	1.4	0.3	0.1	-0.3	1.2	0.3	-0.4
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.9	0.6	-0.1	0.1	0.5	0.8
Mean time to correctly identify matches	2.0	3.9	5.3	2.2	2.3	-1.5	1.6	1.8	2.3
Heart disease (mother)	0.3	0.3	0.7	-0.3	-0.5	-0.1	-0.8	-0.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.2	-1.1	-0.9	-0.1	-0.6	-0.5	-1.8
Whole body fat mass	0.5	2.1	3.5	-1.9	-1.5	1.5	-1.7	-1.3	0.3
Leg fat mass (right)	0.7	2.9	4.9	-2.2	-1.9	1.7	-1.8	-1.6	-0.4
Arm predicted mass (right)	0.4	2.0	5.5	-1.6	-1.5	0.4	-2.4	-0.9	-0.9
Pulse rate, automated reading	0.1	0.3	0.8	0.0	-0.5	0.8	0.9	-0.5	-0.1
Alcohol intake frequency.	0.6	1.3	1.8	1.3	1.1	-1.1	1.1	1.3	0.9
Comparative height size at age 10	0.2	0.9	2.3	1.2	0.5	-1.5	0.1	1.2	-0.1
Number of full sisters	1.0	1.2	2.2	0.9	1.5	-1.3	0.8	1.2	0.7
Suffer from ‘nerves’	0.6	1.0	1.6	-0.8	-1.1	1.1	-0.0	-1.2	-1.3
Overall health rating	0.3	0.6	2.5	0.2	-0.6	-0.2	0.7	-0.0	-1.6
Chest pain or discomfort	0.8	1.1	2.4	1.6	0.6	-1.1	1.2	1.0	-0.4
Had major operations	1.6	1.9	3.7	-1.2	-0.7	1.9	-1.9	-1.5	0.2
Age at last live birth	0.4	0.6	2.2	0.2	0.6	-1.5	-0.1	0.8	0.4
Family relationship satisfaction	4.9	6.0	11.8	3.3	2.0	-2.0	3.4	2.1	0.9
Leg pain on walking	3.0	3.7	4.9	1.9	2.1	-1.8	1.7	1.8	2.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	-0.4	0.0	-0.1	-0.6	0.3	0.3
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.3	-2.1	-2.3	1.8	-0.8	-1.6	-1.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.9	-1.2	-0.8	1.0	-1.4	-1.1	0.4
Medication: Aspirin	0.4	0.5	1.7	0.6	0.1	-0.7	1.3	0.7	-0.4
Supplements: Vitamin C	0.4	0.5	1.1	1.1	0.5	0.1	0.7	0.7	0.8
Knee pain experienced in last month	0.1	0.2	0.7	-0.5	-0.3	0.0	-0.8	0.1	-0.3
Hypertension (Self-reported)	0.4	1.2	4.8	-0.4	-0.8	-0.4	1.2	0.0	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.7	-0.5	0.2	-0.7	-0.2	-1.1
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.1	-0.6	-0.1	-0.3	0.2	-0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.6	0.0	-0.6	-0.5	0.0	0.8	-1.3
Smoking status: Previous	0.2	0.3	0.7	-0.6	-0.1	-0.7	-0.9	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.6	1.1	0.3	-1.3	0.2	1.6	-0.3
Whole body fat-free mass	0.5	2.7	8.1	-1.8	-1.5	0.9	-2.9	-1.2	-0.5
Leg fat-free mass (right)	0.3	1.6	6.5	-1.3	-0.8	0.5	-2.5	-0.6	0.4
Arm fat percentage (left)	0.4	1.6	2.3	-1.5	-1.1	1.4	-1.4	-1.2	0.8
Average weekly red wine intake	1.6	2.3	6.2	0.9	1.7	-2.5	0.0	1.6	1.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.2	1.2	1.2	-1.2	0.9	1.5	1.2
Mood swings	1.0	1.7	3.3	-1.0	-0.9	1.6	-1.5	-1.8	0.6
Loneliness, isolation	0.1	0.2	0.5	0.3	-0.1	0.4	-0.0	-0.5	0.7
Long-standing illness, disability or infirmity	1.5	2.3	5.2	1.4	1.2	-2.3	1.2	1.9	-0.3
Ever had bowel cancer screening	0.3	0.4	0.6	0.5	0.3	-0.4	0.8	0.7	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.2	0.6	-0.3	0.1	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.8	1.1	1.4	-2.0	0.1	1.4	0.4
Friendships satisfaction	4.2	5.2	8.7	2.9	1.8	-2.8	2.6	2.2	-0.2
Qualifications: nursing, teaching	1.6	2.5	4.1	1.5	2.0	-1.2	1.2	1.6	1.8
Commuting to job workplace: Walk	0.4	0.4	0.8	0.6	0.8	-0.8	0.4	0.9	0.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.4	-0.2	-0.7	-0.2	0.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	4.9	2.1	1.3	-2.1	2.0	2.2	0.5
Medication for cholesterol	1.0	1.5	6.5	0.6	1.2	-0.2	0.0	0.8	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.3	0.1	0.5	0.4	-0.2	-0.3
Back pain experienced in last month	0.1	0.2	0.8	0.1	0.2	0.9	0.0	-0.1	0.3
Mineral and other dietary supplements	0.5	0.7	1.9	0.5	0.0	-1.4	1.2	0.6	-0.7
Breast cancer (self-reported)	1.7	2.0	5.5	1.3	0.9	-2.3	1.0	1.7	0.5
Asthma (self-reported)	0.1	0.2	0.5	0.4	0.1	-0.7	0.2	0.4	-0.5
Osteoporosis (self-reported)	1.2	1.4	3.2	1.3	1.8	-0.9	-0.3	1.2	1.3
Osteoarthritis (self-reported)	0.6	0.8	2.4	0.1	-0.3	-1.6	-1.2	0.8	0.1
Medication: Aspirin	0.6	0.8	1.4	0.8	0.6	-1.2	1.1	1.0	0.0
Medication: Gliclazide	0.7	0.8	2.9	0.3	0.3	-1.0	1.7	0.8	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.6	0.5	0.7	1.3	-0.1	0.2
Smoking status: Current	0.2	0.3	0.5	-0.7	-0.3	0.5	-0.2	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.1	0.7	0.2	-0.2	0.2	0.6
Whole body water mass	0.4	2.5	7.9	-1.7	-1.4	0.9	-2.8	-1.2	-0.4
Leg predicted mass (right)	0.3	1.7	6.8	-1.4	-0.9	0.5	-2.6	-0.6	0.3
Arm fat mass (left)	0.7	2.8	4.3	-2.0	-1.6	1.7	-2.1	-1.7	0.2
Number of self-reported non-cancer illnesses	0.3	0.6	1.0	0.9	0.6	-0.6	0.9	1.0	-0.1
Average weekly champagne plus white wine intake	0.9	1.3	2.0	-1.0	-1.2	1.2	-1.4	-1.4	0.1
Miserableness	0.5	0.9	3.3	0.3	0.9	0.7	0.5	-0.5	1.8
Guilty feelings	0.1	0.2	0.3	-0.5	-0.2	0.4	-0.5	-0.5	0.2
Wears glasses or contact lenses	0.6	0.7	1.4	0.7	0.8	-0.4	1.0	1.2	0.8
Ever taken oral contraceptive pill	0.7	0.8	2.1	-0.7	-1.1	0.2	-0.1	-0.8	-1.5
Hearing aid user	1.2	1.4	4.1	0.5	1.3	-1.1	-0.1	1.0	2.0
Mother’s age at death	1.3	1.6	2.6	1.4	1.4	-0.8	1.0	1.1	1.6
Financial situation satisfaction	1.0	1.3	2.7	1.4	0.7	-1.1	1.6	1.0	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	-0.2	-0.2	1.0	-1.4	-0.8	0.1
Commuting to job workplace: Public transport	1.6	1.9	2.7	1.2	1.6	-1.5	0.8	1.4	1.6
Eye problems/disorders: Glaucoma	2.7	3.2	5.3	1.3	2.3	-2.0	1.4	2.2	1.3
Medication: Blood pressure	0.7	1.4	5.0	-0.9	-1.3	0.4	-0.0	-0.8	-2.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.8	1.0	-0.9	-1.1	0.6	0.4	-2.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.5	-0.2	1.4	-1.0	-0.7	0.5
High cholesterol (Self-reported)	0.2	0.4	0.8	-0.4	0.4	0.9	0.5	-0.3	0.9
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.0	0.3	-0.3	0.8	0.1	-0.4
Medication: Paracetamol	0.7	1.1	2.0	-0.9	-0.9	1.4	0.4	-1.3	-1.2
Medication: Lisinopril	0.6	0.7	1.8	-1.2	-0.7	0.5	-0.8	-1.3	-0.2
Medication: Atorvastatin	0.2	0.3	0.6	-0.8	0.5	-0.8	0.3	0.0	-0.4
Illnesses of father: High blood pressure	1.5	1.8	3.4	-1.6	-1.6	0.2	-1.9	-0.8	-1.3
Alcohol drinker status: Never	1.3	1.5	3.5	-0.9	-0.6	1.9	-0.9	-1.9	0.1
Ever smoked	0.1	0.1	0.4	-0.1	0.1	-0.6	-0.0	0.1	-0.5
Basal metabolic rate	0.5	2.7	7.7	-1.8	-1.5	1.1	-2.8	-1.2	-0.3
Leg fat percentage (left)	0.6	2.0	3.3	-1.8	-1.6	1.8	-0.9	-1.6	-0.4
Arm fat-free mass (left)	0.7	3.8	7.7	-2.2	-2.0	1.4	-2.8	-1.7	-1.2
Number of operations (self-reported)	0.3	0.4	1.2	-0.5	-0.7	0.2	-0.1	-0.6	-1.1
Average weekly beer plus cider intake	0.1	0.1	0.2	0.3	0.5	0.1	0.3	0.1	0.3
Irritability	0.4	0.7	1.2	0.8	1.0	-0.9	0.7	1.1	0.3
Risk taking	1.1	1.6	5.8	1.1	0.8	-2.4	-0.2	1.3	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.1	0.6	0.1	-0.6	0.1	0.7
Fractured/broken bones in last 5 years	0.4	0.6	1.2	-0.5	-1.1	0.2	-1.0	-0.6	-0.7
Age started oral contraceptive pill	0.4	0.5	0.9	0.9	0.4	-1.0	0.6	0.8	-0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.0	1.0	0.5	-1.0	0.9	0.6	0.7
Ever depressed for a whole week	1.4	1.8	3.0	1.7	1.4	-1.4	1.4	1.1	0.8
Unable to work because of sickness or disability	0.3	0.5	1.2	0.7	0.1	-1.1	0.4	0.9	-0.3
Commuting to job workplace: Cycle	0.8	0.9	4.2	0.2	1.1	0.3	0.1	0.3	2.0
Myopia	1.9	2.8	4.2	1.9	1.5	-1.9	1.7	2.1	0.1
Vascular/heart problems diagnosed by doctor	1.0	2.6	7.8	1.5	1.9	-0.8	-0.0	1.3	2.8
Cholesterol lowering medication	0.1	0.1	0.3	-0.6	-0.2	0.2	-0.4	-0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.1	0.7	0.6	-0.6	1.8	0.7	-0.3
Pain experienced in last month	0.3	0.5	0.8	-0.7	-0.8	0.2	-0.5	-0.7	-0.9
Supplements: Calcium	0.6	0.7	1.5	1.0	0.7	-0.4	1.2	0.6	0.8
Basal cell carcinoma (self-reported)	1.3	1.5	5.1	-1.3	-0.9	0.8	-2.2	-0.8	0.1
Heart attack/myocardial infarction (self-reported)	1.9	2.4	3.8	-1.8	-1.4	1.9	-0.9	-1.9	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.4	-1.0	0.8	-0.0	-0.6	-1.2
Heart disease (siblings)	0.7	0.8	1.8	1.4	0.8	-0.9	1.1	0.6	-0.0
Alcohol drinker status: Previous	2.3	2.6	3.8	1.5	1.5	-1.9	1.8	1.8	1.1
Pack years of smoking	0.2	0.3	0.5	-0.7	-0.7	0.4	-0.0	-0.7	-0.5
Impedance of whole body	0.3	1.5	3.9	1.5	0.8	-0.8	2.0	1.2	0.4
Leg fat mass (left)	0.7	2.7	4.8	-2.2	-1.7	1.6	-1.8	-1.6	-0.3
Arm predicted mass (left)	0.7	3.6	7.6	-2.1	-2.0	1.4	-2.8	-1.7	-1.0