TWAS hub - CLDN14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.1530	0.0650	0.0006	0.092	0.091	0.109	NA	0.088	5.8e-06	5.9e-06	7.7e-07	NA	9.0e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0476	0.0204	0.0014	0.038	0.021	0.025	NA	0.036	3.7e-05	2.0e-03	6.7e-04	NA	5.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Red Count	8.2	79.1	109.9	7.0	10.5
Medication: Ibuprofen	8.0	9.6	10.6	3.3	2.9
Medication: Ibuprofen (e.g. Nurofen)	7.5	9.5	10.9	3.3	2.8
Tinnitus: Yes, now most or all of the time	6.1	7.1	8.6	2.4	2.9
Age when periods started (menarche)	5.7	13.8	17.9	4.2	3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.4	6.3	7.6	-2.8	-2.2
Asthma	4.8	9.4	11.3	-2.7	-3.4
Asthma (self-reported)	4.6	9.2	10.6	-2.8	-3.3
Pulse wave peak to peak time	4.5	5.3	7.9	-1.7	-2.8
Medication: Atenolol	4.3	5.4	8.5	1.5	2.9
Miserableness	4.3	7.4	8.6	-2.5	-2.9
Had major operations	4.2	5.0	5.3	2.2	2.3
Pain type(s) experienced in last month: Hip pain	3.8	4.7	6.3	-1.8	-2.5
Ever taken oral contraceptive pill	3.6	4.0	5.5	2.4	1.6
Allergy	3.5	8.0	10.7	2.3	3.3
Chronic bronchitis/emphysema (mother)	3.5	4.0	6.0	-2.5	-1.4
Smoking status: Current	3.4	5.4	5.7	2.4	2.2
Smoking status: Previous	3.3	4.9	5.6	-2.4	-2.1
Commuting to job workplace: Public transport	3.3	3.9	4.2	-2.1	-1.9
Primary Biliary Cirrhosis	3.1	4.4	5.7	2.4	1.7
Current tobacco smoking	3.1	5.0	5.5	2.3	2.1
Pulse wave Arterial Stiffness index	3.1	3.7	5.5	1.4	2.3
Number of live births	3.0	4.2	5.1	-1.8	-2.3
Number of children fathered	3.0	3.4	3.7	1.9	1.8
Basal cell carcinoma (self-reported)	3.0	3.6	5.1	2.3	1.4
Crohns Disease (2017)	2.7	5.9	7.6	-2.8	-2.0
Wheeze or whistling in the chest in last year	2.7	4.9	5.1	-2.3	-2.2
HDL Cholesterol	2.6	4.4	5.0	-1.9	-2.2
Relative age voice broke	2.6	3.9	4.2	-1.9	-2.0
Mood swings	2.6	4.6	4.8	-2.1	-2.2
Pack years of smoking	2.6	3.8	4.3	-2.1	-1.8
Ever highly irritable/argumentative for 2 days	2.5	3.0	3.8	-1.5	-1.9
Average weekly beer plus cider intake	2.5	3.6	4.6	2.2	1.6
Ovarian Cancer	2.4	3.2	3.3	-1.8	-1.7
Respiratory disease	2.4	5.3	6.5	-2.0	-2.5
Supplements: Calcium	2.4	2.7	3.8	-1.9	-1.2
Breast Cancer	2.3	5.6	5.6	2.4	2.4
Mouth/teeth dental problems	2.3	3.5	3.7	1.8	1.9
Angina (self-reported)	2.3	3.0	4.9	1.1	2.2
Birth weight	2.2	4.8	5.0	-2.1	-2.2
Angina	2.1	2.7	4.4	1.1	2.1
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	5.5	-1.1	-2.4
Medication: Blood pressure	2.1	3.7	6.3	1.0	2.5
Knee pain experienced in last month	2.1	3.2	3.2	-1.8	-1.8
Diabetes (father)	2.0	2.4	2.8	-1.4	-1.7
Impedance of leg (left)	2.0	9.7	9.8	3.1	3.1
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	3.6	-1.6	-1.9
Medication: Allopurinol	1.9	2.5	3.6	-1.9	-1.2
Depressed Affect (Nagel 2018)	1.8	3.8	4.6	-1.7	-2.2
Allergy or Eczema	1.8	4.8	6.6	-1.7	-2.6
Severe depression (siblings)	1.8	2.1	2.8	1.7	1.1
Impedance of leg (right)	1.8	8.8	8.8	3.0	3.0
Lung cancer (father)	1.8	2.1	2.2	1.4	1.5
Fractured/broken bones in last 5 years	1.8	2.3	2.8	1.7	1.4
Heart attack/myocardial infarction (self-reported)	1.8	2.4	4.2	0.7	2.1
Age at First Birth	1.7	2.5	3.1	1.3	1.8
Hayfever, allergic rhinitis or eczema	1.7	3.7	5.9	-1.2	-2.4
Had menopause	1.7	2.1	3.1	-1.8	-1.1
Heart attack	1.7	2.2	4.1	0.5	2.0
Pain all over the body in last month	1.7	1.9	2.2	1.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	3.9	-1.2	-2.0
Schizophrenia vs Biploar Disorder	1.6	2.1	3.1	1.7	1.1
Alzheimer’s Disease (including proxy)	1.6	2.3	2.6	-1.6	-1.5
Pack years adult smoking proportion	1.6	2.4	2.4	-1.6	-1.5
Alzheimer’s Disease (in father)	1.5	1.6	2.4	-0.9	-1.5
Reaction Time	1.5	2.8	3.2	-1.5	-1.8
Lupus	1.5	2.3	3.2	-1.2	-1.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.0	-1.2	-1.4
Leg predicted mass (left)	1.5	7.8	8.2	-2.9	-2.7
Number of incorrect matches in round	1.5	2.5	3.7	1.2	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	5.0	-1.3	-2.2
Worrier / anxious feelings	1.5	2.8	3.1	1.8	1.6
Exposure to tobacco smoke at home	1.5	1.7	1.9	1.4	1.2
Migraine (self-reported)	1.5	1.8	2.6	-1.1	-1.6
Mean time to correctly identify matches	1.5	2.9	3.4	-1.9	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	1.9	-1.2	-1.4
Alcohol drinker status: Never	1.5	1.7	1.8	-1.4	-1.3
Depression (Nagel 2018)	1.4	2.1	2.9	-1.1	-1.7
Leg fat-free mass (left)	1.4	7.7	8.1	-2.8	-2.7
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.0	-1.4	-1.2
Hair/balding pattern: Pattern 4	1.4	3.4	4.0	2.0	1.7
Leg fat-free mass (right)	1.4	7.4	7.4	-2.7	-2.7
Breast cancer (self-reported)	1.4	1.7	1.7	1.3	1.3
Eye problems/disorders: Glaucoma	1.4	1.7	3.1	1.7	0.5
Impedance of whole body	1.4	6.9	7.7	2.8	2.5
Body mass index (BMI)	1.3	5.5	8.5	-2.9	-1.5
Medication: Lansoprazole	1.3	1.5	2.1	1.5	0.9
Illnesses of mother	1.3	1.6	2.5	1.6	0.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	2.8	1.7	1.1
Medication: Gliclazide	1.3	1.5	2.4	1.6	0.8
Leg predicted mass (right)	1.3	7.0	7.1	-2.6	-2.7
Number of operations (self-reported)	1.3	1.9	2.8	1.7	0.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	1.7	1.0	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	4.4	-1.1	-2.1
Weight	1.2	5.9	8.4	-2.9	-1.8
Hair/balding pattern: Pattern 3	1.2	1.8	2.3	-1.5	-1.1
Arm fat mass (right)	1.2	5.0	8.1	-2.8	-1.4
Birth weight of first child	1.2	2.3	3.1	-1.8	-1.2
Glaucoma (self-reported)	1.2	1.4	2.6	1.6	0.4
Arm fat-free mass (right)	1.2	6.0	7.5	-2.7	-2.1
Comparative body size at age 10	1.2	3.4	3.5	-1.9	-1.8
Eye problems/disorders: Cataract	1.2	1.4	2.3	-1.5	-0.7
Risk taking	1.2	1.7	2.2	-1.1	-1.5
High blood pressure	1.1	3.2	6.0	-2.4	-0.6
Financial difficulties in last 2 years	1.1	1.5	2.8	0.6	1.7
Gout (self-reported)	1.1	1.5	2.7	-1.6	-0.6
Whole body fat mass	1.1	4.4	7.5	-2.7	-1.2
Leg pain on walking	1.1	1.3	2.0	0.8	1.4
Illnesses of siblings: Diabetes	1.1	1.3	2.2	-1.5	-0.7
Whole body fat-free mass	1.1	6.3	6.9	-2.6	-2.4
Osteoporosis (self-reported)	1.1	1.4	1.8	1.0	1.3
Basal metabolic rate	1.1	6.0	7.0	-2.6	-2.3
Arm fat-free mass (left)	1.1	5.7	7.3	-2.7	-2.0
LDL Cholesterol	1.0	1.5	2.0	1.0	1.4
Blood White Count	1.0	7.2	10.0	2.1	3.2
Medication: Co-codamol	1.0	1.2	1.8	-1.3	-0.8
Falls in the last year	1.0	1.3	1.3	-1.1	-1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	2.1	-1.4	-1.1
Whole body water mass	1.0	5.6	6.1	-2.5	-2.3
Arm fat mass (left)	1.0	4.1	7.1	-2.7	-1.0
Medication: Blood pressure	1.0	2.0	2.3	-1.5	-1.3
Body Mass Index (BMI) (2010)	0.9	1.2	2.3	0.4	1.5
Waist Hip Ratio (WHR)	0.9	4.0	4.2	2.1	1.9
Trunk fat-free mass	0.9	5.0	5.4	-2.3	-2.2
Trunk predicted mass	0.9	5.2	5.6	-2.4	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	1.8	0.9	1.3
Shortness of breath walking on level ground	0.9	1.1	1.9	-1.4	-0.5
Arm predicted mass (right)	0.9	4.8	6.1	-2.5	-1.9
Mother’s age at death	0.9	1.1	1.2	1.0	1.1
Cholesterol lowering medication	0.9	1.3	1.8	-1.3	-0.9
Alcohol drinker status: Previous	0.9	1.0	1.7	-0.5	-1.3
Neuroticism (2016)	0.8	1.2	2.0	1.4	0.6
Rheumatoid Arthritis	0.8	1.1	1.7	-1.3	-0.7
Blood Eosinophil Count	0.8	6.3	6.5	-2.6	-2.5
Age at first live birth	0.8	1.4	2.0	0.9	1.4
Supplements: Vitamin C	0.8	0.9	1.8	1.3	0.3
Medication for cholesterol	0.8	1.1	1.3	1.1	1.0
Back pain experienced in last month	0.8	1.2	1.9	-0.7	-1.4
Leg fat mass (left)	0.8	3.1	5.6	-2.4	-0.7
Arm predicted mass (left)	0.8	4.3	5.6	-2.4	-1.8
Neuroticism (Nagel 2018)	0.7	1.7	2.1	-1.1	-1.4
Blood Platelet Count	0.7	7.6	9.4	-2.4	-3.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.1	-0.7	-1.0
Trunk fat mass	0.7	3.2	5.4	-2.3	-1.0
Past tobacco smoking	0.7	1.2	1.6	1.3	0.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	1.3	0.3
Impedance of arm (right)	0.7	3.3	4.1	2.0	1.6
Arm fat percentage (right)	0.7	2.7	4.9	-2.2	-0.8
Noisy workplace	0.7	0.9	1.0	1.0	0.9
Impedance of arm (left)	0.7	3.2	3.8	2.0	1.6
Headache pain in last month	0.7	1.2	2.0	1.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.1	-0.7	-1.5
Neck or shoulder pain in last month	0.7	1.0	1.9	-0.4	-1.4
Medication: Seretide 50 evohaler	0.7	0.8	1.2	-0.7	-1.1
Leg fat mass (right)	0.7	2.7	5.0	-2.2	-0.6
Comparative height size at age 10	0.7	3.6	3.8	-1.9	-1.8
Commuting to job workplace: Car/motor vehicle	0.7	0.9	0.9	0.9	0.9
Hypertension (Self-reported)	0.7	1.8	3.6	-1.9	-0.3
Arm fat percentage (left)	0.7	2.8	5.1	-2.3	-0.7
Loneliness, isolation	0.7	1.0	1.3	0.8	1.1
Unable to work because of sickness or disability	0.7	0.9	1.1	1.1	0.8
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.8	1.9	-0.1
Prostate Cancer	0.6	0.8	1.4	1.2	0.4
Triglycerides	0.6	1.0	1.7	0.5	1.3
BMI	0.6	3.4	5.8	-2.4	-1.0
Hearing difficulty/problems: Yes	0.6	1.0	1.0	1.0	1.0
Hip circumference	0.6	2.5	4.4	-2.1	-0.8
Pulse rate	0.6	1.0	1.0	1.0	1.0
Qualifications: College or University degree	0.6	1.9	2.6	1.6	1.1
Eye problems/disorders: None of the above	0.6	0.7	1.3	-0.3	-1.1
Alcohol intake frequency.	0.6	1.3	2.0	-0.8	-1.4
Illnesses of father: Heart disease	0.6	0.8	1.1	0.8	1.0
Ever depressed for a whole week	0.6	0.7	0.9	-0.9	-0.7
Myopia	0.6	0.8	1.2	-0.7	-1.1
Schizophrenia (2018)	0.5	1.0	1.1	1.1	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-1.0	-0.5
Fasting Glucose	0.5	0.5	1.1	-0.2	1.0
Hand grip strength (left)	0.5	1.3	1.6	-1.0	-1.3
Qualifications: CSEs or equivalent	0.5	0.7	0.8	-0.9	-0.7
Medication: Levothyroxine sodium	0.5	0.8	1.3	-0.5	-1.2
Sitting height	0.5	3.9	6.4	2.5	1.2
Qualifications: None of the above	0.5	1.0	1.5	-1.2	-0.7
Depression (self-reported)	0.5	0.7	0.7	-0.8	-0.8
Breastfed as a baby	0.5	0.6	0.9	-0.9	-0.6
Loud music exposure frequency	0.5	0.5	0.7	-0.8	-0.6
Body fat percentage	0.5	2.1	4.0	-2.0	-0.4
Emphysema/chronic bronchitis	0.5	0.6	0.9	0.9	0.6
Osteoarthritis (self-reported)	0.5	0.6	1.2	-1.1	-0.0
Irritable Bowel Disease (IBD)	0.4	1.0	1.9	-1.4	-0.2
Schizophrenia (2014)	0.4	0.8	0.9	0.9	0.9
Trunk fat percentage	0.4	1.7	3.2	-1.8	-0.5
Hand grip strength (right)	0.4	1.1	1.5	-0.8	-1.2
Medication: Cholesterol lowering	0.4	0.6	1.2	0.0	1.1
Tense / ‘highly strung’	0.4	0.7	0.7	-0.8	-0.9
Chest pain or discomfort	0.4	0.6	0.8	-0.6	-0.9
Age at last live birth	0.4	0.6	0.7	0.8	0.8
Medication: Aspirin	0.4	0.5	0.9	0.0	1.0
Diabetes diagnosed by doctor	0.4	0.6	0.7	0.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.1	-0.9
Bipolar Disorder (2018)	0.3	0.4	0.6	-0.5	0.8
Bipolar Disorder or Schizophrenia	0.3	0.9	1.4	0.5	1.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.1	-1.1	-0.8
Ulcerative Colitis (UC)	0.3	0.6	1.1	-0.1	1.1
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.8	0.3
Crohns Disease (2012)	0.3	0.5	0.9	-0.9	-0.4
Heel T-Score	0.3	2.0	2.9	-1.1	-1.7
Lung FVC	0.3	1.5	1.9	1.4	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.4	-0.8
Medication: Metformin	0.3	0.5	0.6	0.6	0.7
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.3	0.9
Average weekly fortified wine intake	0.3	0.3	0.6	-0.3	0.8
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.9	-0.3
Had other major operations	0.3	0.4	0.5	0.7	0.6
Diabetes (self-reported)	0.3	0.5	1.0	0.1	1.0
Medication: Simvastatin	0.3	0.4	0.8	-0.9	-0.2
Length of working week for main job	0.3	0.4	0.4	-0.7	-0.6
Medication: Paracetamol	0.3	0.6	0.9	0.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.5	-0.8
Leg fat percentage (right)	0.3	1.1	2.1	-1.4	0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.8	-0.4
Heart disease (mother)	0.3	0.3	0.6	-0.8	-0.2
Number of full sisters	0.3	0.4	0.5	0.5	-0.7
Suffer from ‘nerves’	0.3	0.5	0.9	0.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.3	-0.8
Friendships satisfaction	0.3	0.3	0.5	0.7	0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.4	0.6	0.6
Wears glasses or contact lenses	0.3	0.4	0.6	0.7	0.4
Illnesses of father: High blood pressure	0.3	0.4	0.5	0.7	0.4
Leg fat percentage (left)	0.3	1.2	2.2	-1.5	0.4
Irritability	0.3	0.6	1.0	-0.4	-1.0
Age started oral contraceptive pill	0.3	0.4	0.7	0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	-0.9	0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.5	-0.4
Maternal smoking around birth	0.2	0.3	0.6	0.8	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	-0.2
Nervous feelings	0.2	0.5	0.9	-0.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	0.7	-0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.8	0.3
Father’s age at death	0.2	0.3	0.5	0.7	0.1
Happiness	0.2	0.2	0.3	0.5	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.9	1.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.6	0.3
Health satisfaction	0.2	0.2	0.4	-0.6	-0.2
Family relationship satisfaction	0.2	0.2	0.4	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.7	0.0
Medication: Aspirin	0.2	0.3	0.6	-0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	0.7	0.6
Medication: Atorvastatin	0.2	0.2	0.5	-0.7	-0.2
Commuting to job workplace: Cycle	0.2	0.3	0.4	0.7	-0.3
Worry (Nagel 2018)	0.1	0.2	0.5	-0.1	-0.7
Mean Putamen Volume	0.1	0.1	0.1	0.3	0.2
Ulcerative Colitis	0.1	0.2	0.4	-0.1	0.6
Height	0.1	2.9	3.7	-1.4	-1.9
Systolic Blood Pressure	0.1	0.7	1.4	0.0	-1.2
Smoking Status	0.1	0.2	0.3	0.6	0.2
Cardiovascular Disease	0.1	0.3	0.3	-0.5	0.6
Hypothyroidism (self reported)	0.1	0.2	0.3	0.3	-0.5
Neuroticism	0.1	0.1	0.2	0.3	-0.4
Number of treatments/medications taken	0.1	0.1	0.2	-0.0	0.5
Sensitivity / hurt feelings	0.1	0.1	0.2	0.2	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.2	-0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.3	0.2
Systolic blood pressure, automated reading	0.1	0.4	0.4	-0.6	-0.6
Vitamin and mineral supplements	0.1	0.1	0.3	-0.5	-0.0
Supplements: Zinc	0.1	0.1	0.1	0.1	0.4
Fed-up feelings	0.1	0.2	0.3	0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.1	-0.5
Multivitamins +/- minerals	0.1	0.1	0.2	-0.3	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.2	0.5
High blood pressure (mother)	0.1	0.1	0.2	0.5	0.2
Waist circumference	0.1	0.4	0.7	-0.8	0.2
Alcohol usually taken with meals	0.1	0.1	0.2	-0.5	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	-0.4
Medication: Ramipril	0.1	0.1	0.2	-0.1	-0.4
Fluid intelligence score	0.1	0.2	0.3	-0.6	-0.3
Time employed in main current job	0.1	0.2	0.3	-0.1	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.2	-0.4
Pulse wave reflection index	0.1	0.2	0.3	-0.1	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.3	0.2
Medication: Amlodipine	0.1	0.2	0.2	-0.5	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	0.8	0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.2	0.4	0.4
Worry too long after embarrassment	0.1	0.2	0.2	-0.5	-0.5
Medication: Omeprazole	0.1	0.1	0.1	-0.3	0.3
Pulse rate, automated reading	0.1	0.2	0.3	0.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.2	0.4	0.4
Average weekly red wine intake	0.1	0.2	0.4	0.0	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.5	-0.0
Mineral and other dietary supplements	0.1	0.2	0.2	0.3	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.1	-0.3	-0.4
Guilty feelings	0.1	0.1	0.2	0.5	-0.0
Hearing aid user	0.1	0.1	0.2	-0.3	-0.4
Financial situation satisfaction	0.1	0.1	0.1	-0.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.4	0.1
High cholesterol (Self-reported)	0.1	0.1	0.1	-0.3	0.4
Medication: Paracetamol	0.1	0.1	0.2	0.5	-0.2
Ever smoked	0.1	0.2	0.3	-0.3	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.3	0.4
Pain experienced in last month	0.1	0.2	0.4	0.0	0.7
Major Depression (MDD)	0.0	0.0	0.1	0.0	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.0
HbA1C	0.0	0.0	0.0	-0.0	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	0.1
Lung FEV1/FVC ratio	0.0	0.1	0.3	0.1	0.5
Chronotype (morning person)	0.0	0.0	0.0	0.1	-0.2
Hair Pigment	0.0	0.4	0.7	0.8	0.1
Tanning	0.0	0.3	0.6	0.3	0.8
Average weekly spirits intake	0.0	0.1	0.1	-0.3	0.1
Relative age of first facial hair	0.0	0.1	0.2	0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	0.2
Medication for hormone replacement therapy	0.0	0.0	0.0	0.2	-0.0
Diabetes (mother)	0.0	0.0	0.0	0.0	0.0
Taking other prescription medications	0.0	0.0	0.0	-0.0	0.1
Supplements: Glucosamine	0.0	0.0	0.0	0.2	-0.1
Forced vital capacity (FVC)	0.0	0.1	0.1	0.2	-0.4
Illnesses of siblings	0.0	0.0	0.0	0.2	0.1
Neuroticism score	0.0	0.1	0.1	0.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.1	-0.4
Prospective memory result	0.0	0.0	0.1	0.2	0.2
Standing height	0.0	0.3	0.5	-0.2	-0.7
Peak expiratory flow (PEF)	0.0	0.0	0.0	-0.1	-0.1
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.1	0.3
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	0.1
Number of full brothers	0.0	0.1	0.1	0.3	0.2
Overall health rating	0.0	0.1	0.1	-0.3	-0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.1	0.2
Ever had bowel cancer screening	0.0	0.0	0.1	-0.3	0.0
Qualifications: nursing, teaching	0.0	0.0	0.0	0.2	-0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	0.2	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.0	-0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.1	0.1
Medication: Lisinopril	0.0	0.0	0.0	-0.0	-0.0
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.1	0.3
Heart disease (siblings)	0.0	0.1	0.1	-0.3	0.2

Hub : Genes

CLDN14

Models

Trait associations