Hub : Genes

CLEC14A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1350	0.0480	0.00076	0.056	NA	0.102	NA	0.106	4.7e-05	NA	4.3e-08	NA	2.4e-08
2	TCGA	Lung Adenocarcinoma	0.0589	0.0282	0.00110	0.029	0.016	0.010	NA	0.015	2.1e-04	0.0051	2.2e-02	NA	6.3e-03
3	TCGA	Lung Squamous Cell Carcinoma	0.0661	0.0353	0.00740	0.003	0.005	0.004	NA	-0.001	1.3e-01	0.0700	9.0e-02	NA	4.0e-01
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0640	0.0300	0.00420	0.047	0.023	0.018	NA	0.021	4.1e-04	0.0110	2.1e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.2	0.1	0.2	0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	0.4	0.7	0.5	0.5
Depressed Affect (Nagel 2018)	0.5	1.0	2.5	-1.6	-0.7	-0.7	0.6
Depression (Nagel 2018)	0.8	1.2	2.8	0.3	-0.4	-1.7	-1.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.7	0.9	-0.1	-2.4	-1.3
Neuroticism (Nagel 2018)	0.5	1.2	3.7	-1.9	0.5	0.2	0.8
Schizophrenia (2018)	0.2	0.5	0.8	0.7	0.9	0.5	0.6
Schizophrenia vs Biploar Disorder	1.1	1.5	3.2	1.8	-0.7	-1.1	-1.0
Worry (Nagel 2018)	0.6	1.2	3.0	-1.7	1.4	0.2	0.3
Alzheimer’s Disease (in mother)	0.5	0.5	1.1	-1.1	-0.2	0.9	0.5
Alzheimer’s Disease (in father)	1.4	1.5	5.8	2.4	0.1	-0.4	0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	0.5	0.3	0.8	1.1
Crohns Disease (2017)	1.4	3.1	5.8	-0.1	1.8	1.9	2.4
Irritable Bowel Disease (IBD)	0.6	1.4	2.1	0.2	1.3	1.4	1.3
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	0.0	0.2	-0.8
Major Depression (MDD)	1.7	2.0	3.4	1.8	-1.4	-1.1	-1.3
Reaction Time	1.7	3.2	4.1	-1.9	2.0	1.2	1.9
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.6	0.8	-1.5	-2.1	-2.0
Breast Cancer	0.1	0.1	0.3	0.5	0.6	-0.0	0.0
Ovarian Cancer	0.5	0.6	1.9	-0.4	-1.4	-0.6	-0.3
Prostate Cancer	1.9	2.7	4.1	-0.9	2.0	1.9	1.5
Age at First Birth	0.6	0.9	2.3	-0.5	0.4	1.5	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.1	2.9	4.7	0.9	-1.9	-2.2	-1.6
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.3	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.5	3.2	0.5	1.8	0.7	1.5
Mean Putamen Volume	2.2	2.5	5.6	2.4	-0.5	-1.4	-1.5
Fasting Glucose	0.5	0.6	1.8	0.1	-0.7	-0.6	-1.3
HbA1C	1.4	1.6	2.1	1.3	1.5	-1.4	-0.7
HDL Cholesterol	0.2	0.3	0.7	0.7	0.5	0.0	0.8
LDL Cholesterol	0.1	0.2	0.7	-0.4	-0.8	0.3	-0.1
Lupus	0.6	0.9	2.3	-0.7	1.5	0.6	0.8
Neuroticism (2016)	0.2	0.2	0.6	0.3	-0.1	0.6	-0.8
Primary Biliary Cirrhosis	0.3	0.5	0.8	0.8	0.8	-0.9	0.2
Rheumatoid Arthritis	0.1	0.2	0.6	-0.2	0.2	0.8	-0.3
Schizophrenia (2014)	0.4	0.8	1.6	1.3	0.9	0.5	0.8
Triglycerides	0.1	0.2	0.4	-0.5	-0.0	0.6	0.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.1	-1.2	1.9	0.9	2.0
Ulcerative Colitis	0.2	0.3	0.7	-0.7	0.2	0.8	-0.3
Blood Eosinophil Count	0.2	1.2	2.6	-0.3	-1.6	-1.3	-0.8
Blood Platelet Count	0.2	1.8	2.9	0.3	-1.7	-1.7	-1.1
Blood Red Count	0.1	1.4	2.6	-1.0	1.3	0.7	1.6
Blood White Count	0.3	1.9	4.5	0.2	-2.1	-1.7	-0.7
Heel T-Score	0.0	0.2	0.4	-0.1	0.1	-0.6	0.6
BMI	2.1	11.9	30.2	1.5	-2.8	-5.5	-2.7
Height	0.7	13.3	16.1	3.7	-4.0	-2.7	-4.0
Waist Hip Ratio (WHR)	0.3	1.3	3.0	0.1	1.0	1.7	1.1
Systolic Blood Pressure	0.1	0.5	1.1	-0.6	1.1	0.3	0.6
Smoking Status	1.3	3.0	4.7	2.1	-2.2	-0.8	-1.5
Allergy or Eczema	0.1	0.3	0.7	-0.0	0.8	0.6	0.2
Cardiovascular Disease	0.0	0.1	0.4	0.2	0.7	-0.2	0.1
Hypothyroidism (self reported)	0.2	0.5	1.4	-1.2	-0.3	-0.8	0.0
Respiratory disease	0.7	1.5	3.7	1.2	0.1	-1.9	1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.7	0.4	0.4	0.0	2.2
Lung FEV1/FVC ratio	0.7	3.5	5.8	-1.9	1.5	2.4	1.5
Lung FVC	0.8	4.2	13.2	-0.2	1.4	3.6	1.3
Neuroticism	0.2	0.6	1.8	-1.3	0.4	0.4	0.6
Chronotype (morning person)	0.3	0.6	1.5	0.1	1.2	0.0	1.0
Hair Pigment	0.0	0.8	2.0	0.4	1.4	1.0	0.3
Tanning	0.1	0.8	1.7	1.0	-0.4	-1.3	0.3
Hand grip strength (left)	0.1	0.3	0.5	0.7	-0.5	0.5	-0.6
Number of treatments/medications taken	0.2	0.4	1.2	0.5	-0.2	-1.1	0.1
Average weekly spirits intake	0.8	1.0	1.8	-0.2	-1.1	-1.1	-1.3
Sensitivity / hurt feelings	0.8	1.3	1.6	-1.2	1.3	0.7	1.3
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.6	1.0	-1.4	-1.6	-1.9
Hearing difficulty/problems: Yes	1.2	1.8	3.4	1.1	-1.1	-1.8	-1.2
Relative age of first facial hair	1.0	2.1	3.7	1.9	-1.6	0.4	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	-0.9	-0.7	-1.4	-0.2
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.8	-1.2	1.1	-0.7	2.2
Ever had hysterectomy (womb removed)	0.8	0.9	3.1	-1.8	0.5	0.6	0.2
Systolic blood pressure, automated reading	0.7	2.0	3.4	-1.6	1.8	1.1	1.0
Eye problems/disorders: Diabetes related eye disease	3.3	3.6	6.4	-1.1	2.4	1.1	2.5
Angina	0.5	0.7	2.3	0.0	0.6	0.0	1.5
Medication for hormone replacement therapy	1.9	2.1	3.3	-1.8	0.9	1.1	1.8
Vitamin and mineral supplements	0.3	0.4	1.1	-0.7	-0.3	0.1	-1.1
Supplements: Zinc	0.7	0.8	2.0	1.4	0.8	-0.3	0.5
Medication: Co-codamol	5.4	6.3	11.1	2.0	-2.5	-2.0	-3.3
Medication: Metformin	1.7	2.4	5.1	2.3	0.2	-1.6	1.3
Diabetes (father)	1.4	1.7	2.6	1.0	1.6	0.9	1.6
Diabetes (mother)	1.2	1.5	2.9	1.6	0.3	-1.7	-0.6
Severe depression (siblings)	2.9	3.3	4.5	1.5	-2.1	-1.5	-2.1
Pack years adult smoking proportion	3.1	4.7	11.9	2.0	-1.1	-3.5	-1.4
Impedance of leg (right)	1.6	7.5	15.5	-1.8	1.9	3.9	2.8
Leg fat-free mass (left)	2.2	11.4	14.1	3.1	-3.3	-3.8	-3.4
Trunk fat percentage	1.2	4.8	13.5	1.3	-1.5	-3.7	-1.3
Hand grip strength (right)	0.8	2.2	3.1	1.5	-1.7	-0.6	-1.8
Townsend deprivation index at recruitment	1.2	1.7	2.5	0.5	-1.5	-1.6	-1.4
Current tobacco smoking	1.4	2.3	6.4	2.5	-1.3	-1.1	-0.1
Average weekly fortified wine intake	0.1	0.2	0.5	-0.0	-0.1	-0.4	-0.7
Maternal smoking around birth	0.8	1.2	2.3	0.2	-1.3	-1.5	-0.7
Fed-up feelings	0.5	0.9	2.2	-1.5	0.5	-0.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.7	0.7	-1.1	-2.2	-1.3
Relative age voice broke	0.2	0.4	0.6	0.8	0.4	0.1	0.8
Taking other prescription medications	0.4	0.6	2.4	0.3	-0.1	-1.6	-0.0
Age when periods started (menarche)	0.5	1.2	4.1	0.4	0.1	0.7	-2.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	-0.4	1.2	-0.7	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.4	-0.2	-1.2	-0.7	-1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.3	-0.6	-0.6	-0.8
Qualifications: CSEs or equivalent	0.8	1.1	3.4	-1.8	-0.6	0.9	0.1
Serious illness, injury or assault to yourself	1.7	2.0	3.8	0.2	-1.8	-0.9	-1.9
High blood pressure	0.1	0.3	0.5	0.7	0.1	-0.5	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.2	0.4	0.2	0.5
Multivitamins +/- minerals	1.0	1.2	1.9	1.3	-1.4	-1.0	-0.6
Stomach or abdominal pain in last month	2.6	3.3	6.4	0.6	-2.5	-0.2	-2.5
Supplements: Glucosamine	2.3	3.0	5.0	1.2	-2.1	-1.2	-2.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	1.4	-0.8	-0.6	-0.5
Medication: Atenolol	0.8	0.9	2.7	-0.9	0.2	1.7	0.4
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.9	0.1	-0.0	0.7
Sitting height	1.4	9.7	14.2	2.3	-3.5	-2.7	-3.8
Chronic bronchitis/emphysema (father)	1.1	1.3	2.7	1.2	-0.9	-1.6	-0.7
High blood pressure (mother)	0.5	0.6	2.3	0.2	1.5	-0.1	0.4
Body mass index (BMI)	1.5	6.5	16.5	1.4	-2.0	-4.1	-1.9
Impedance of leg (left)	1.0	4.9	11.9	-1.8	1.3	3.5	1.7
Leg predicted mass (left)	2.3	12.2	15.1	3.2	-3.3	-3.9	-3.5
Trunk fat mass	1.7	7.2	16.4	2.0	-2.2	-4.0	-2.0
Waist circumference	1.6	6.0	11.3	1.9	-2.1	-3.4	-2.2
Number of incorrect matches in round	1.7	2.8	4.6	-1.6	1.8	2.1	1.0
Past tobacco smoking	0.7	1.2	2.0	-1.1	1.4	0.6	1.1
Alcohol usually taken with meals	0.6	0.9	1.4	0.8	1.2	0.8	1.0
Nervous feelings	0.6	1.2	2.4	-1.6	1.5	0.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.9	-0.3	-0.1	-1.4	-0.8
Hearing difficulty/problems with background noise	1.1	1.8	2.9	0.9	-1.3	-1.7	-1.4
Hair/balding pattern: Pattern 2	1.0	1.3	4.0	0.1	-1.0	-2.0	-0.3
Had menopause	2.6	3.2	6.0	-2.5	1.6	1.2	1.7
Had other major operations	0.4	0.4	0.8	-0.9	0.3	-0.7	0.7
Forced vital capacity (FVC)	0.2	0.9	1.9	0.7	-0.8	1.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.7	-0.1	-1.2	-0.8	-1.3
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	5.7	0.6	-0.2	-1.5	-2.4
Qualifications: None of the above	0.2	0.5	0.8	-0.8	0.0	-0.9	-0.7
Financial difficulties in last 2 years	0.4	0.5	0.8	0.8	-0.7	-0.3	-0.9
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	0.2	0.4	-0.7
Heart attack	0.3	0.3	1.1	-0.1	-0.4	-0.2	-1.1
Allergy	0.2	0.4	0.6	-0.3	0.7	0.8	-0.7
Pain all over the body in last month	1.0	1.0	1.9	-0.7	-1.4	-1.2	-0.4
Diabetes (self-reported)	0.5	0.8	1.6	1.2	-0.1	0.0	1.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.5	1.2	-0.2	-0.5	-0.1
Medication: Ramipril	1.7	2.2	7.2	2.7	-0.4	-1.2	-0.2
Medication: Simvastatin	0.7	1.0	2.9	0.8	0.3	-1.7	-0.6
Fluid intelligence score	0.9	1.8	4.2	1.4	-0.2	-2.0	-0.9
Illnesses of siblings	1.3	1.9	4.2	-0.6	-2.1	0.4	-1.6
Neuroticism score	0.3	0.7	2.3	-1.5	-0.1	-0.6	-0.1
Weight	2.3	11.2	19.9	2.6	-3.0	-4.5	-3.1
Impedance of arm (right)	0.2	0.8	1.2	0.0	1.1	1.0	0.9
Arm fat percentage (right)	1.1	4.4	13.0	1.5	-1.2	-3.6	-1.0
Trunk fat-free mass	1.2	7.0	7.9	2.8	-2.5	-2.5	-2.8
Hip circumference	2.5	10.7	17.1	1.8	-3.1	-4.1	-3.6
Time employed in main current job	0.3	0.3	0.6	-0.8	0.7	0.1	0.4
Alcohol intake versus 10 years previously	1.6	2.4	3.4	-1.6	1.4	1.4	1.8
Father’s age at death	0.1	0.2	0.5	-0.3	-0.7	0.3	-0.1
Worrier / anxious feelings	0.3	0.5	0.7	-0.3	0.8	0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	0.3	0.5	0.4
Falls in the last year	1.9	2.6	6.1	-0.0	-1.7	-1.2	-2.5
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	-0.9	1.6	1.7	0.3
Number of live births	0.4	0.6	2.0	-1.4	0.2	0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	4.5	-0.4	-0.1	2.1	0.1
Pulse rate	0.6	1.0	3.8	-0.2	1.9	0.5	0.1
Happiness	3.0	3.6	5.5	-1.6	2.2	1.2	2.3
Noisy workplace	0.7	0.9	1.5	-0.1	-1.0	-1.2	-1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.9	0.2	-1.4	-1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.5	-1.1	1.2	0.5	0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	-0.7	0.1	-1.0	0.3
Asthma	0.7	1.5	3.3	1.8	-0.6	-1.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.1	-0.6	0.4	0.1
Medication: Cholesterol lowering	0.4	0.5	1.8	0.2	1.3	0.1	0.6
Depression (self-reported)	0.8	1.0	3.8	0.3	0.3	-2.0	-0.2
Medication: Lansoprazole	2.1	2.4	5.4	-0.9	-0.5	-1.8	-2.3
Prospective memory result	3.0	3.7	5.9	-1.6	2.4	0.8	2.3
Lung cancer (father)	0.9	1.0	2.0	-0.5	1.4	-0.4	1.3
Illnesses of mother	0.2	0.2	0.4	0.1	-0.4	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.6	1.3	-0.2	1.2	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.1	0.2	0.1	0.9
Impedance of arm (left)	0.3	1.4	2.9	-0.4	1.3	1.7	1.1
Arm fat mass (right)	1.4	5.9	14.7	1.7	-2.0	-3.8	-1.6
Trunk predicted mass	1.2	6.8	7.7	2.7	-2.5	-2.4	-2.8
Standing height	0.6	5.5	8.4	2.9	-2.2	-1.4	-2.7
Length of working week for main job	0.6	0.7	1.8	-1.3	-0.5	-0.4	0.7
Exposure to tobacco smoke at home	0.9	1.0	1.5	-1.1	0.5	-1.2	0.9
Breastfed as a baby	1.7	2.1	3.8	0.7	-1.4	-1.5	-2.0
Tense / ‘highly strung’	1.0	1.6	5.3	-2.3	-0.1	0.8	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	-1.6	0.2	-0.9	0.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.6	-1.0	0.4	-0.6
Birth weight of first child	0.4	0.6	1.3	-0.8	0.2	0.8	1.1
Peak expiratory flow (PEF)	0.5	1.1	3.7	-0.6	-0.4	1.9	0.3
Pulse wave reflection index	0.4	0.5	0.9	-0.0	-0.9	1.0	0.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.7	0.4	-0.4	-1.3	-1.3
Loud music exposure frequency	3.1	3.4	6.9	2.6	-1.1	-1.6	-1.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.3	-0.5	-0.8	0.2	1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.5	-0.7	0.7	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.5	-0.2	-0.4	0.6	1.2
Medication: Paracetamol	0.8	1.3	4.3	-2.1	-0.6	0.7	-0.2
Headache pain in last month	0.8	1.3	2.0	-1.4	0.7	1.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.8	-0.1	1.1	-0.3
Glaucoma (self-reported)	0.3	0.4	0.7	-0.9	0.5	-0.0	0.7
Gout (self-reported)	0.4	0.5	1.1	0.3	-0.3	-1.0	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.6	-1.3	0.1	-0.7	0.8
Medication: Amlodipine	0.9	1.3	2.2	1.5	-0.6	-1.0	-1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.7	1.0	-1.6	-1.5	-0.4
Birth weight	1.5	3.2	4.4	1.3	-1.7	-2.1	-2.0
Chronic bronchitis/emphysema (mother)	6.1	7.1	11.8	1.7	-2.5	-2.8	-3.4
High blood pressure (siblings)	0.6	0.9	2.3	0.7	1.5	-0.5	0.7
Forced vital capacity (FVC), Best measure	0.6	2.4	5.5	2.4	-1.2	0.2	-1.6
Body fat percentage	1.1	4.1	12.1	1.2	-1.4	-3.5	-1.1
Leg fat percentage (right)	0.6	2.3	7.0	0.6	-1.3	-2.6	-0.6
Arm fat-free mass (right)	1.3	6.8	8.3	2.0	-2.6	-2.9	-2.9
Exposure to tobacco smoke outside home	2.5	3.3	6.6	0.5	-1.9	-1.6	-2.6
Comparative body size at age 10	0.6	1.8	3.7	1.9	-0.6	-1.7	-0.2
Number of full brothers	0.5	0.6	1.7	-1.3	0.2	0.8	0.2
Worry too long after embarrassment	0.3	0.6	1.5	-0.5	1.2	0.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.8	0.0	-1.2	-2.4	-1.7
Wheeze or whistling in the chest in last year	1.6	2.8	5.6	2.4	-1.2	-1.8	-0.9
Number of children fathered	0.9	1.0	1.8	1.2	0.3	-1.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	4.8	0.6	2.1	1.8	2.2
Age at first live birth	0.5	1.0	2.0	-0.4	-0.5	1.2	-1.4
Pulse wave peak to peak time	0.2	0.2	0.8	0.1	-0.2	-0.0	-0.9
Health satisfaction	1.1	1.4	3.0	-0.8	1.7	0.3	1.4
Shortness of breath walking on level ground	0.5	0.6	1.8	-1.3	-0.6	-0.1	-0.3
Qualifications: College or University degree	0.4	1.1	3.3	1.8	-0.7	-0.3	-0.7
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.6	0.3	-0.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	0.5	-1.1	-0.2	-0.8
Emphysema/chronic bronchitis	1.7	1.9	3.8	-0.6	-1.7	-1.9	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	1.1	-0.2	-0.8	0.4
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.8	-0.3	-0.8	-0.4
Medication: Blood pressure	0.3	0.6	1.2	0.8	-0.7	-1.1	-0.0
Angina (self-reported)	0.7	0.9	3.1	-0.2	0.8	0.2	1.7
Migraine (self-reported)	0.5	0.6	2.2	-0.1	0.1	1.5	0.5
Medication: Ibuprofen	0.2	0.3	0.5	-0.7	-0.1	0.6	0.5
Medication: Allopurinol	1.2	1.6	4.5	1.1	-0.8	-2.1	-0.2
Medication: Omeprazole	0.4	0.5	1.3	-0.7	1.1	0.3	0.1
Medication: Seretide 50 evohaler	0.5	0.6	1.9	-0.4	-0.5	-0.4	1.4
Mean time to correctly identify matches	1.6	3.1	4.4	-2.1	1.9	1.1	1.8
Heart disease (mother)	0.7	0.8	1.7	-1.3	0.8	0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.3	0.7	-0.1	-0.2
Whole body fat mass	1.7	7.1	16.2	1.8	-2.2	-4.0	-2.0
Leg fat mass (right)	1.9	7.3	14.7	1.7	-2.6	-3.8	-2.2
Arm predicted mass (right)	1.5	7.8	9.4	2.4	-2.7	-3.1	-3.0
Pulse rate, automated reading	0.3	0.8	1.2	0.1	1.0	1.1	1.1
Alcohol intake frequency.	1.1	2.6	4.6	-0.9	2.1	0.8	2.1
Comparative height size at age 10	0.2	1.1	2.3	1.5	-1.0	0.9	-0.2
Number of full sisters	0.8	0.9	2.2	-0.1	1.2	0.3	1.5
Suffer from ‘nerves’	0.2	0.3	1.1	-0.3	-0.2	-1.1	-0.3
Overall health rating	0.1	0.2	0.4	0.3	-0.5	-0.5	0.6
Chest pain or discomfort	0.8	1.2	1.9	-0.9	-1.1	-1.4	-0.9
Had major operations	2.5	3.0	7.2	0.8	-1.8	-1.0	-2.7
Age at last live birth	0.2	0.3	0.5	-0.7	0.3	0.7	-0.2
Family relationship satisfaction	0.5	0.7	1.3	-0.2	1.0	0.4	1.1
Leg pain on walking	0.2	0.2	0.4	-0.2	0.4	-0.6	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.1	0.2	-1.1	-1.5	-1.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.5	0.7	-0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	1.5	-0.1	-1.5	-0.4
Medication: Aspirin	0.1	0.2	0.6	0.2	0.1	0.8	0.0
Supplements: Vitamin C	0.4	0.5	1.8	0.0	1.3	0.4	0.4
Knee pain experienced in last month	1.4	2.1	3.2	-1.5	-1.7	0.5	-1.8
Hypertension (Self-reported)	0.0	0.1	0.3	-0.0	0.6	-0.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.6	-0.0	-0.2	-0.9	-1.6
Illnesses of father: Heart disease	1.3	1.8	3.6	-1.9	-0.2	1.9	0.4
Illnesses of siblings: Diabetes	1.4	1.8	5.6	0.5	2.4	0.3	1.0
Smoking status: Previous	0.7	1.1	1.7	0.7	-1.3	-0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.2	1.5	-1.7	-0.2	-1.8
Whole body fat-free mass	1.7	9.5	10.6	3.0	-2.9	-3.2	-3.3
Leg fat-free mass (right)	2.4	12.7	14.5	3.2	-3.5	-3.8	-3.8
Arm fat percentage (left)	1.1	4.6	13.0	1.4	-1.4	-3.6	-1.1
Average weekly red wine intake	0.3	0.5	1.2	-0.3	0.9	0.0	1.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.5	0.1	-0.8	0.3
Mood swings	0.9	1.6	4.3	-0.8	-2.1	-0.7	-1.0
Loneliness, isolation	0.1	0.2	0.5	-0.7	-0.2	-0.4	-0.2
Long-standing illness, disability or infirmity	0.6	0.9	2.0	-0.5	-1.4	-0.7	-1.0
Ever had bowel cancer screening	0.6	0.8	2.3	0.1	0.7	-1.5	-0.4
Diabetes diagnosed by doctor	0.7	1.2	4.3	0.6	0.0	0.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.4	-1.1	-1.5	-0.4	-0.3
Friendships satisfaction	0.7	0.8	2.1	-1.1	0.2	0.2	1.5
Qualifications: nursing, teaching	0.9	1.5	3.3	0.3	-1.8	-0.7	-1.4
Commuting to job workplace: Walk	1.8	2.0	3.3	-1.8	0.6	1.8	1.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.3	0.5	0.5	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.3	0.3	-0.1	-1.5	0.2
Medication for cholesterol	0.7	1.1	2.4	-0.5	-1.4	-0.1	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.1	0.4	-1.1	-1.5	-0.4
Back pain experienced in last month	0.4	0.6	1.7	-1.3	0.7	0.6	0.3
Mineral and other dietary supplements	0.3	0.3	0.7	-0.2	0.8	0.8	0.1
Breast cancer (self-reported)	1.0	1.1	2.4	-0.9	-0.2	-1.2	-1.5
Asthma (self-reported)	0.7	1.5	2.8	1.7	-0.8	-1.6	0.0
Osteoporosis (self-reported)	0.4	0.4	0.9	-0.5	-0.4	-0.9	-0.7
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.6	0.1	-0.2	0.4
Medication: Aspirin	0.1	0.1	0.5	0.2	-0.0	0.7	-0.0
Medication: Gliclazide	1.2	1.3	3.1	0.3	1.4	-0.2	1.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	-0.5	0.9	-0.3	-0.2
Smoking status: Current	1.2	2.0	6.5	2.5	-0.9	-0.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.9	0.0	1.3	1.7	0.7
Whole body water mass	1.6	9.4	10.6	2.9	-2.8	-3.3	-3.2
Leg predicted mass (right)	2.3	12.2	14.3	3.1	-3.4	-3.7	-3.8
Arm fat mass (left)	1.5	6.0	15.2	1.6	-1.8	-3.9	-1.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.2	0.3	-0.0	0.8
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.1	-0.3	-0.1	0.1
Miserableness	0.1	0.2	0.6	-0.8	-0.1	-0.4	0.2
Guilty feelings	1.0	1.6	3.6	0.1	1.6	-0.2	1.9
Wears glasses or contact lenses	1.3	1.5	3.8	-1.9	0.9	1.0	0.4
Ever taken oral contraceptive pill	2.1	2.3	5.1	2.3	-1.3	-1.5	-0.1
Hearing aid user	0.1	0.2	0.5	0.7	0.3	-0.2	-0.2
Mother’s age at death	0.1	0.1	0.2	-0.0	0.1	-0.4	-0.3
Financial situation satisfaction	0.6	0.7	2.0	0.9	-0.2	-1.4	0.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.5	0.5	1.6	-1.3	1.1
Commuting to job workplace: Public transport	0.3	0.3	0.9	-0.9	0.6	-0.1	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	-0.8	-0.4	-0.6	0.7
Medication: Blood pressure	0.7	1.4	2.9	1.5	1.7	-0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.6	0.1	0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.5	0.2	-0.4	-0.0
High cholesterol (Self-reported)	0.5	0.9	2.3	-0.2	1.5	-0.2	1.1
Medication: Bendroflumethiazide	0.9	1.3	2.9	1.7	1.1	-0.8	-0.7
Medication: Paracetamol	0.7	1.0	2.2	-1.5	-1.1	0.3	-0.8
Medication: Lisinopril	0.5	0.7	1.7	0.7	-0.6	-1.3	0.5
Medication: Atorvastatin	1.7	2.1	3.4	-1.2	1.8	0.5	1.9
Illnesses of father: High blood pressure	1.3	1.6	3.1	1.8	-0.6	-1.1	-1.3
Alcohol drinker status: Never	5.8	7.0	12.0	-2.5	2.7	1.5	3.5
Ever smoked	0.7	1.3	2.0	1.4	-0.9	-1.3	-0.6
Basal metabolic rate	1.9	10.3	12.6	2.9	-3.1	-3.6	-3.3
Leg fat percentage (left)	0.9	3.1	8.7	0.6	-1.5	-3.0	-1.1
Arm fat-free mass (left)	1.4	7.2	10.1	2.2	-2.4	-3.2	-2.8
Number of operations (self-reported)	0.4	0.6	1.9	-0.3	-0.7	-0.4	-1.4
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.9	-0.2	0.9	-0.3
Irritability	1.1	1.8	4.8	-2.2	-0.1	1.4	0.6
Risk taking	0.6	0.9	2.6	1.6	-0.8	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.5	1.6	0.3	-0.6	-1.0
Fractured/broken bones in last 5 years	0.8	1.1	2.4	0.2	-1.6	0.2	-1.4
Age started oral contraceptive pill	0.5	0.6	1.9	-0.1	1.4	-0.6	0.4
Diastolic blood pressure, automated reading	0.7	2.2	5.1	-2.2	1.1	1.4	0.9
Ever depressed for a whole week	0.2	0.2	0.4	-0.3	-0.6	0.1	-0.6
Unable to work because of sickness or disability	0.9	1.2	2.3	-1.1	-1.5	-1.0	-0.5
Commuting to job workplace: Cycle	0.4	0.5	1.6	-0.2	0.6	0.1	1.3
Myopia	0.2	0.3	0.8	-0.9	0.1	-0.5	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	-0.9	-0.3	0.3	0.2
Cholesterol lowering medication	0.4	0.6	1.3	0.8	0.7	0.0	1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.3	-1.5	0.8	0.1	-0.8
Pain experienced in last month	1.0	1.7	6.6	2.6	0.1	-0.6	0.2
Supplements: Calcium	0.8	0.9	2.2	0.7	0.9	0.1	1.5
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	-0.0	0.1	1.1	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.1	-0.5	-0.2	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	0.0	-0.6	0.0	1.0
Heart disease (siblings)	0.5	0.6	1.4	1.2	0.5	-0.8	0.0
Alcohol drinker status: Previous	2.2	2.5	9.4	3.1	-0.2	-0.3	-0.7
Pack years of smoking	3.0	4.4	12.0	1.9	-0.6	-3.5	-1.2
Impedance of whole body	0.6	2.9	6.4	-1.0	1.4	2.5	1.4
Leg fat mass (left)	2.2	8.5	17.3	1.7	-2.8	-4.2	-2.4
Arm predicted mass (left)	1.3	6.7	9.6	2.1	-2.2	-3.1	-2.8