TWAS hub - CLEC4GP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.700	0.0280	0	0.582	0.585	0.687	0.688	0.683	2.2e-87	3.9e-88	1.1e-115	4.9e-116	2.1e-114
2	TCGA	Brain Lower Grade Glioma	0.229	0.0499	0	0.195	0.251	0.232	NA	0.254	1.2e-21	2.5e-28	4.7e-26	NA	1.2e-28

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	12.5	92.7	104.0	-9.0	-10.2
Medication: Simvastatin	9.6	14.0	14.1	-3.8	-3.7
LDL Cholesterol	6.3	10.0	12.0	-3.5	-2.8
Rheumatoid Arthritis	5.5	7.6	8.0	-2.8	-2.7
Medication: Cholesterol lowering	5.4	8.4	9.5	-2.7	-3.1
High cholesterol (Self-reported)	4.3	7.6	8.6	-2.6	-2.9
Time employed in main current job	3.1	3.5	4.4	2.1	1.6
Eye problems/disorders: Glaucoma	3.1	3.7	4.6	-2.2	-1.7
Smoking Status	3.0	7.1	8.8	3.0	2.3
Asthma (self-reported)	3.0	5.9	5.9	-2.4	-2.4
Medication for cholesterol	2.7	4.1	5.7	1.6	2.4
Blood Eosinophil Count	2.5	19.2	20.2	-4.2	-4.5
Financial difficulties in last 2 years	2.5	3.3	3.3	1.8	1.8
Asthma	2.5	4.9	5.3	-2.3	-2.1
Glaucoma (self-reported)	2.5	3.0	3.7	-1.9	-1.5
Relative age voice broke	2.4	3.6	3.8	-1.9	-1.9
Ever highly irritable/argumentative for 2 days	2.3	2.8	3.7	-1.9	-1.3
Father’s age at death	2.1	2.9	3.7	1.4	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	3.0	1.2	1.7
Financial situation satisfaction	2.1	2.6	3.0	-1.5	-1.7
Cholesterol lowering medication	2.1	3.2	3.6	-1.7	-1.9
Ever depressed for a whole week	2.0	2.4	2.7	-1.6	-1.5
Vitamin and mineral supplements	1.9	2.6	2.7	-1.6	-1.6
Multivitamins +/- minerals	1.9	2.4	3.2	1.8	1.3
Cardiovascular Disease	1.8	6.0	7.4	-2.1	-2.7
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	3.2	-1.8	-1.1
Diabetes (self-reported)	1.8	2.8	3.5	-1.4	-1.9
Loneliness, isolation	1.8	2.5	2.6	1.6	1.6
Lupus	1.7	2.6	2.7	-1.6	-1.6
Pain all over the body in last month	1.7	1.8	2.0	1.3	1.4
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	3.7	1.4	1.9
Alzheimer’s Disease (in father)	1.6	1.7	2.5	-1.0	-1.6
Diabetes diagnosed by doctor	1.6	2.7	3.0	-1.5	-1.7
Medication: Blood pressure	1.6	3.0	3.2	-1.7	-1.8
Prostate Cancer	1.5	2.1	3.2	1.8	1.1
Relative age of first facial hair	1.5	3.0	3.1	-1.7	-1.8
Lung cancer (father)	1.5	1.7	2.0	-1.2	-1.4
Health satisfaction	1.5	2.0	2.4	-1.3	-1.5
Illnesses of father: Heart disease	1.5	2.1	2.4	-1.3	-1.6
Bipolar Disorder (2018)	1.4	2.2	2.6	-1.4	-1.6
HbA1C	1.4	1.6	2.3	-0.9	-1.5
Current tobacco smoking	1.4	2.3	4.2	2.0	0.7
Worry too long after embarrassment	1.4	2.4	2.9	-1.7	-1.4
Alzheimer’s Disease (in mother)	1.3	1.5	2.0	1.0	1.4
High blood pressure (siblings)	1.3	1.9	2.5	-1.1	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.7	-1.3	-1.1
Smoking status: Current	1.3	2.1	3.9	2.0	0.6
Medication: Co-codamol	1.2	1.4	2.0	-0.9	-1.4
Number of children fathered	1.2	1.3	1.8	-1.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.5	-1.2	-1.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	1.8	1.3	1.1
Neuroticism (2016)	1.1	1.6	1.6	-1.3	-1.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	2.5	1.5	1.6
Qualifications: None of the above	1.1	2.3	2.7	-1.7	-1.4
Angina (self-reported)	1.1	1.5	2.0	-1.0	-1.4
Migraine (self-reported)	1.1	1.3	2.0	1.4	0.8
Eye problems/disorders: Cataract	1.1	1.3	1.4	-1.1	-1.2
Ever smoked	1.1	2.0	3.0	1.7	0.9
Angina	1.0	1.3	1.9	-0.8	-1.4
Fed-up feelings	1.0	1.8	2.0	1.4	1.2
Miserableness	1.0	1.7	1.8	-1.3	-1.3
Average weekly beer plus cider intake	1.0	1.5	2.5	-0.7	-1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.6	1.3	0.8
Heart disease (siblings)	1.0	1.3	2.3	-1.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.7	1.7	-1.3	-1.3
Number of treatments/medications taken	0.9	1.6	2.2	-1.0	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.0	1.4	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.5	1.2	0.7
Had major operations	0.9	1.1	1.4	1.2	0.8
Age at last live birth	0.9	1.3	1.3	-1.1	-1.1
Commuting to job workplace: Public transport	0.9	1.1	1.5	1.2	0.9
Primary Biliary Cirrhosis	0.8	1.1	1.5	0.9	1.2
Had other major operations	0.8	0.9	1.1	1.0	0.9
Medication: Ramipril	0.8	1.1	1.6	-1.3	-0.7
Loud music exposure frequency	0.8	0.8	1.6	1.3	0.2
Medication: Ibuprofen	0.8	0.9	1.8	-0.2	-1.3
Medication: Seretide 50 evohaler	0.8	0.9	1.8	-1.3	-0.1
Comparative height size at age 10	0.8	4.2	5.1	2.3	1.8
Family relationship satisfaction	0.8	1.0	1.3	-0.8	-1.2
Smoking status: Previous	0.8	1.2	1.8	0.7	1.4
HDL Cholesterol	0.7	1.2	1.9	-0.7	-1.4
Average weekly spirits intake	0.7	0.9	0.9	-1.0	-0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	1.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.2	-0.7	-1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	1.1	0.8
Depression (self-reported)	0.7	0.9	1.2	1.1	0.8
Medication: Lansoprazole	0.7	0.8	1.3	-0.6	-1.1
Pulse wave Arterial Stiffness index	0.7	0.8	0.9	0.9	0.9
Length of working week for main job	0.7	0.8	1.0	-1.0	-0.7
Medication: Amlodipine	0.7	1.0	1.5	-0.8	-1.2
Number of full brothers	0.7	0.8	1.7	0.0	1.3
Breast cancer (self-reported)	0.7	0.9	1.6	1.3	0.3
Ever taken oral contraceptive pill	0.7	0.8	1.1	1.1	0.7
Depressed Affect (Nagel 2018)	0.6	1.3	1.4	1.2	1.1
Alzheimer’s Disease (including proxy)	0.6	0.8	1.3	1.1	0.6
Ulcerative Colitis (UC)	0.6	1.2	1.6	-0.8	-1.3
Respiratory disease	0.6	1.3	1.8	-0.9	-1.4
Chronotype (morning person)	0.6	1.4	2.3	-1.5	-0.7
Supplements: Zinc	0.6	0.7	0.7	0.9	0.8
High blood pressure (mother)	0.6	0.8	1.4	-0.4	-1.2
Mouth/teeth dental problems	0.6	0.9	1.2	1.1	0.8
Pulse rate	0.6	0.9	1.6	-1.3	-0.5
Pulse wave reflection index	0.6	0.8	0.9	1.0	0.8
Medication: Aspirin	0.6	0.8	1.2	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.5	-1.2	-1.0
Osteoarthritis (self-reported)	0.6	0.8	1.0	-1.0	-0.8
Medication: Gliclazide	0.6	0.7	0.8	-0.7	-0.9
Medication: Atorvastatin	0.6	0.8	1.4	-0.4	-1.2
Irritable Bowel Disease (IBD)	0.5	1.2	1.6	-1.3	-0.9
Body Mass Index (BMI) (2010)	0.5	0.7	1.0	-0.6	-1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.6	-0.7	-0.8
Medication: Metformin	0.5	0.7	0.9	-1.0	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.3	-1.1
Illnesses of siblings	0.5	0.7	1.1	1.0	0.5
Worrier / anxious feelings	0.5	1.0	1.1	-1.1	-1.0
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	-1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-0.1	-1.1
Pulse wave peak to peak time	0.5	0.6	0.6	-0.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	0.4	1.2
Heart disease (mother)	0.5	0.6	1.1	-0.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.7	-0.9	-0.6
Medication: Bendroflumethiazide	0.5	0.7	1.0	-1.0	-0.6
Risk taking	0.5	0.7	0.8	0.9	0.7
Crohns Disease (2017)	0.4	0.8	1.5	-1.2	-0.2
Reaction Time	0.4	0.8	1.1	1.0	0.8
Lung FEV1/FVC ratio	0.4	1.9	1.9	1.4	1.3
Maternal smoking around birth	0.4	0.6	0.9	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.2	-1.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.8	0.4	0.9
High blood pressure	0.4	1.2	1.3	-1.1	-1.1
Past tobacco smoking	0.4	0.8	0.8	-0.9	-0.9
Falls in the last year	0.4	0.6	0.7	-0.8	-0.7
Number of live births	0.4	0.5	0.6	0.8	0.7
Mean time to correctly identify matches	0.4	0.8	1.1	1.0	0.7
Hypertension (Self-reported)	0.4	1.0	1.1	-1.0	-1.0
Friendships satisfaction	0.4	0.6	0.8	-0.9	-0.5
Back pain experienced in last month	0.4	0.6	0.7	-0.8	-0.7
Medication: Aspirin	0.4	0.6	0.9	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	1.5	0.9	1.2
Pain experienced in last month	0.4	0.7	1.3	-0.3	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.6	0.7	-0.8	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.8	0.5
Fasting Glucose	0.3	0.3	0.4	0.5	0.6
Hand grip strength (left)	0.3	0.7	1.1	-0.6	-1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.5	0.7	0.6
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.9	-0.3
Average weekly fortified wine intake	0.3	0.3	0.6	-0.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.3	-0.9
Supplements: Glucosamine	0.3	0.4	0.8	0.9	-0.1
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.5	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.0	-1.0	-0.6
Allergy	0.3	0.7	0.9	-0.7	-0.9
Hip circumference	0.3	1.2	1.3	1.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.2	-1.0
Arm fat mass (right)	0.3	1.1	1.2	1.0	1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.4	0.5	0.6
Overall health rating	0.3	0.6	1.1	-0.4	-1.0
Knee pain experienced in last month	0.3	0.5	0.9	-0.9	-0.3
Osteoporosis (self-reported)	0.3	0.3	0.5	0.3	0.7
Medication: Paracetamol	0.3	0.4	0.5	0.7	0.6
Illnesses of father: High blood pressure	0.3	0.4	0.4	-0.6	-0.6
Alcohol drinker status: Never	0.3	0.4	0.7	-0.9	-0.2
Number of operations (self-reported)	0.3	0.4	0.4	0.6	0.7
Irritability	0.3	0.6	0.8	0.6	0.9
Commuting to job workplace: Cycle	0.3	0.4	0.6	0.8	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	-0.0	0.8
Depression (Nagel 2018)	0.2	0.3	0.4	0.6	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	-0.9	-0.5
Ulcerative Colitis	0.2	0.2	0.3	0.6	-0.3
BMI	0.2	1.1	1.3	1.1	1.0
Waist Hip Ratio (WHR)	0.2	1.1	1.8	-0.5	-1.4
Allergy or Eczema	0.2	0.6	0.6	0.8	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.5	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.1	-0.7
Systolic blood pressure, automated reading	0.2	0.5	0.7	-0.6	-0.8
Diabetes (mother)	0.2	0.3	0.4	-0.6	-0.5
Severe depression (siblings)	0.2	0.2	0.4	-0.0	-0.7
Impedance of leg (right)	0.2	1.2	1.5	-1.2	-0.9
Serious illness, injury or assault to yourself	0.2	0.3	0.3	-0.5	-0.6
Sitting height	0.2	1.7	1.8	1.3	1.4
Impedance of leg (left)	0.2	1.0	1.1	-1.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.0	0.7
Arm fat percentage (right)	0.2	0.8	0.9	0.9	0.9
Happiness	0.2	0.2	0.3	-0.4	-0.5
Noisy workplace	0.2	0.2	0.4	-0.6	-0.2
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.2	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.0	0.7
Birth weight	0.2	0.4	0.4	-0.7	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.3
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.2	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.3	-0.7
Medication: Allopurinol	0.2	0.3	0.5	-0.4	-0.7
Leg fat mass (right)	0.2	0.6	0.9	0.6	1.0
Alcohol intake frequency.	0.2	0.4	0.4	-0.6	0.6
Leg fat-free mass (right)	0.2	1.1	1.2	1.0	1.1
Arm fat percentage (left)	0.2	0.9	0.9	0.9	1.0
Commuting to job workplace: Walk	0.2	0.2	0.2	0.5	0.4
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	-0.4
Leg predicted mass (right)	0.2	1.1	1.2	1.0	1.1
Arm fat mass (left)	0.2	1.0	1.2	0.9	1.1
Guilty feelings	0.2	0.3	0.6	-0.3	-0.8
Wears glasses or contact lenses	0.2	0.2	0.4	-0.1	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.6	0.4
Myopia	0.2	0.2	0.3	0.6	0.4
Leg fat mass (left)	0.2	0.6	0.9	0.6	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.6	-0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.2	0.3	0.5
Major Depression (MDD)	0.1	0.2	0.3	0.0	-0.6
Breast Cancer	0.1	0.2	0.3	-0.6	-0.3
Age at First Birth	0.1	0.2	0.3	0.6	0.1
Mean Putamen Volume	0.1	0.1	0.2	0.4	-0.0
Schizophrenia (2014)	0.1	0.2	0.3	0.4	-0.5
Triglycerides	0.1	0.1	0.2	-0.2	-0.5
Blood Platelet Count	0.1	1.4	1.7	1.3	1.1
Heel T-Score	0.1	0.6	1.0	-0.5	-1.0
Sensitivity / hurt feelings	0.1	0.1	0.1	-0.4	-0.3
Diabetes (father)	0.1	0.1	0.2	-0.2	0.4
Leg fat-free mass (left)	0.1	0.8	1.0	0.7	1.0
Trunk fat percentage	0.1	0.5	0.7	0.5	0.8
Hand grip strength (right)	0.1	0.2	0.4	-0.3	-0.6
Taking other prescription medications	0.1	0.2	0.2	-0.5	-0.4
Age when periods started (menarche)	0.1	0.3	0.4	-0.5	-0.6
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.1	0.3
Medication: Atenolol	0.1	0.1	0.1	-0.2	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	-0.2
Body mass index (BMI)	0.1	0.6	0.7	0.7	0.8
Leg predicted mass (left)	0.1	0.8	1.0	0.7	1.0
Trunk fat mass	0.1	0.5	0.8	0.5	0.9
Waist circumference	0.1	0.4	0.6	0.7	0.5
Number of incorrect matches in round	0.1	0.1	0.2	-0.5	-0.1
Alcohol usually taken with meals	0.1	0.1	0.2	-0.5	-0.1
Had menopause	0.1	0.1	0.2	-0.2	-0.5
Heart attack	0.1	0.2	0.2	-0.3	-0.5
Weight	0.1	0.7	0.8	0.7	0.9
Trunk fat-free mass	0.1	0.5	0.6	0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.4	-0.3
Prospective memory result	0.1	0.2	0.2	0.5	0.4
Illnesses of mother	0.1	0.1	0.2	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.7	0.1
Trunk predicted mass	0.1	0.4	0.6	0.5	0.8
Breastfed as a baby	0.1	0.1	0.1	0.4	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.4
Birth weight of first child	0.1	0.1	0.2	-0.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.0	-0.6
Headache pain in last month	0.1	0.1	0.2	0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.4	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.2	0.4	0.4
Body fat percentage	0.1	0.4	0.6	0.5	0.8
Arm fat-free mass (right)	0.1	0.7	0.9	0.6	1.0
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.3	0.3
Age at first live birth	0.1	0.2	0.2	-0.3	-0.5
Shortness of breath walking on level ground	0.1	0.2	0.3	0.5	0.3
Qualifications: College or University degree	0.1	0.3	0.5	0.7	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.4	-0.2
Neck or shoulder pain in last month	0.1	0.1	0.1	0.4	0.3
Medication: Blood pressure	0.1	0.3	0.3	-0.5	-0.5
Whole body fat mass	0.1	0.4	0.7	0.4	0.8
Arm predicted mass (right)	0.1	0.7	1.0	0.5	1.0
Chest pain or discomfort	0.1	0.1	0.1	0.3	-0.4
Leg pain on walking	0.1	0.1	0.3	0.1	-0.5
Supplements: Vitamin C	0.1	0.1	0.2	0.4	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.2	-0.5
Whole body fat-free mass	0.1	0.5	0.7	0.6	0.8
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	0.2
Ever had bowel cancer screening	0.1	0.1	0.3	0.2	0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.5	0.1
Whole body water mass	0.1	0.6	0.8	0.6	0.9
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.1	0.6
Mother’s age at death	0.1	0.2	0.3	0.5	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.0	-0.5
Medication: Lisinopril	0.1	0.1	0.1	0.2	-0.3
Basal metabolic rate	0.1	0.7	0.9	0.7	0.9
Arm fat-free mass (left)	0.1	0.6	0.9	0.6	0.9
Age started oral contraceptive pill	0.1	0.1	0.1	-0.2	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	-0.4
Arm predicted mass (left)	0.1	0.3	0.5	0.4	0.7
Schizophrenia (2018)	0.0	0.1	0.2	0.4	-0.1
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.2
Ovarian Cancer	0.0	0.0	0.1	-0.1	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	-0.0	0.0
Blood Red Count	0.0	0.0	0.1	-0.3	0.1
Height	0.0	0.2	0.3	-0.5	0.4
Systolic Blood Pressure	0.0	0.0	0.0	-0.0	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.1	0.4	0.1
Lung FVC	0.0	0.2	0.4	0.6	-0.1
Neuroticism	0.0	0.0	0.0	-0.1	-0.1
Hair Pigment	0.0	0.1	0.2	0.4	0.2
Tanning	0.0	0.1	0.1	-0.2	-0.3
Hearing difficulty/problems: Yes	0.0	0.1	0.1	0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.1	-0.3
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	-0.2
Pack years adult smoking proportion	0.0	0.1	0.1	0.4	0.1
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	0.2
Nervous feelings	0.0	0.0	0.1	0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.2	-0.2
Forced vital capacity (FVC)	0.0	0.2	0.3	0.6	0.0
Fluid intelligence score	0.0	0.1	0.1	-0.3	-0.3
Neuroticism score	0.0	0.0	0.1	0.3	0.0
Impedance of arm (right)	0.0	0.2	0.3	-0.3	-0.6
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.2	0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.2	-0.2
Impedance of arm (left)	0.0	0.0	0.0	-0.1	-0.2
Standing height	0.0	0.4	0.7	0.5	0.8
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.4	0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.2	-0.0
Medication: Paracetamol	0.0	0.0	0.1	0.3	0.1
Gout (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.1	-0.3
Leg fat percentage (right)	0.0	0.2	0.3	0.2	0.6
Comparative body size at age 10	0.0	0.1	0.3	-0.5	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.2	-0.1
Medication: Omeprazole	0.0	0.0	0.0	0.0	0.1
Pulse rate, automated reading	0.0	0.0	0.1	-0.0	0.3
Number of full sisters	0.0	0.0	0.0	-0.1	-0.1
Suffer from ‘nerves’	0.0	0.1	0.1	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.1	-0.2
Average weekly red wine intake	0.0	0.0	0.0	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	0.3	0.2
Mood swings	0.0	0.1	0.1	0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.0	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.0	0.2
Hearing aid user	0.0	0.0	0.1	0.1	-0.2
Leg fat percentage (left)	0.0	0.2	0.3	0.2	0.5
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.2	0.2
Diastolic blood pressure, automated reading	0.0	0.1	0.1	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	-0.1
Supplements: Calcium	0.0	0.0	0.0	-0.1	-0.1
Alcohol drinker status: Previous	0.0	0.0	0.0	0.2	-0.2
Pack years of smoking	0.0	0.0	0.0	0.0	-0.1
Impedance of whole body	0.0	0.3	0.3	-0.5	-0.5

Hub : Genes

CLEC4GP1

Models

Trait associations