Hub : Genes

CLN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.098	0.0490	1.3e-03	-0.003	NA	0.026	NA	-0.003	9.3e-01	NA	1.7e-03	NA	7.3e-01
2	YFS	Blood	0.150	0.0413	2.1e-14	0.018	0.058	0.064	0.068	0.047	1.1e-06	2.1e-18	4.7e-20	2e-21	4.2e-15
3	TCGA	Liver Hepatocellular Carcinoma	0.100	0.0740	8.2e-03	-0.001	0.019	0.004	NA	0.002	3.6e-01	4.2e-02	1.9e-01	NA	2.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	1.5	-1.1	-1.1	1.2
Bipolar Disorder or Schizophrenia	0.6	1.4	1.7	-1.3	-1.3	1.0
Depressed Affect (Nagel 2018)	1.1	2.4	4.8	-1.5	-0.1	2.2
Depression (Nagel 2018)	0.2	0.3	0.5	-0.3	-0.6	0.7
Intelligence (Savage-Jansen 2018)	7.2	22.1	51.3	2.4	3.0	-7.2
Neuroticism (Nagel 2018)	0.4	0.9	1.8	-1.3	-0.6	0.9
Schizophrenia (2018)	0.2	0.4	0.6	-0.7	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.0	1.1	-0.2
Worry (Nagel 2018)	0.7	1.4	2.6	-1.6	-0.6	1.1
Alzheimer’s Disease (in mother)	0.9	1.0	1.5	1.2	0.8	-1.0
Alzheimer’s Disease (in father)	0.7	0.7	1.6	1.3	-0.5	0.5
Alzheimer’s Disease (including proxy)	1.1	1.6	3.8	1.9	1.0	-0.3
Crohns Disease (2017)	5.2	11.4	28.2	-1.1	-2.2	5.3
Irritable Bowel Disease (IBD)	5.5	13.0	30.9	-1.1	-2.6	5.6
Ulcerative Colitis (UC)	2.7	5.1	8.8	-1.1	-2.3	3.0
Major Depression (MDD)	0.6	0.7	1.2	0.4	-1.1	-0.9
Reaction Time	2.3	4.4	5.6	-2.1	-1.8	-2.4
Verbal and Numeric Reasoning (VNR)	6.1	14.6	31.5	2.3	2.7	-5.6
Breast Cancer	0.4	1.1	3.0	-0.4	1.7	-0.1
Ovarian Cancer	0.3	0.4	1.0	1.0	0.3	0.1
Prostate Cancer	0.5	0.7	1.3	-1.1	-1.0	-0.0
Age at First Birth	0.1	0.2	0.4	-0.3	-0.6	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.6	4.4	-2.1	-0.6	0.0
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.0	-0.9	0.0
Crohns Disease (2012)	6.0	9.6	23.8	-1.3	-1.8	4.9
Mean Putamen Volume	2.8	3.2	8.1	0.5	-1.1	-2.9
Fasting Glucose	0.1	0.1	0.3	-0.2	-0.5	0.0
HbA1C	0.2	0.2	0.4	-0.6	-0.4	0.0
HDL Cholesterol	0.3	0.5	1.2	1.1	0.5	0.0
LDL Cholesterol	0.2	0.2	0.5	-0.5	-0.7	0.0
Lupus	0.1	0.1	0.2	-0.1	-0.4	0.5
Neuroticism (2016)	1.6	2.3	6.7	-2.6	-0.4	0.2
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.0	0.6	-0.9
Rheumatoid Arthritis	2.4	3.3	5.6	-1.9	-0.9	2.4
Schizophrenia (2014)	0.3	0.6	1.0	-1.0	-0.9	-0.0
Triglycerides	0.0	0.0	0.0	-0.1	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.2	0.8	0.0
Ulcerative Colitis	1.8	2.7	6.1	-0.6	-1.2	2.5
Blood Eosinophil Count	0.4	2.8	4.2	-2.0	-1.3	1.6
Blood Platelet Count	12.4	143.2	306.2	-6.2	-17.5	-9.2
Blood Red Count	2.8	27.0	61.0	4.4	0.8	-7.8
Blood White Count	0.9	6.7	19.7	0.0	-4.4	0.7
Heel T-Score	0.1	1.1	2.0	-0.2	1.4	-1.2
BMI	9.6	55.7	125.4	-5.8	-2.8	11.2
Height	0.4	6.8	13.9	-2.5	-0.7	3.7
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-1.2	-0.1	0.4
Systolic Blood Pressure	0.1	0.5	1.3	0.3	-1.1	0.4
Smoking Status	1.2	2.9	8.7	-0.3	2.9	0.2
Allergy or Eczema	5.6	14.8	40.2	1.9	-0.9	-6.3
Cardiovascular Disease	1.8	5.9	8.2	-2.8	-1.4	2.9
Hypothyroidism (self reported)	4.6	10.5	17.8	-3.6	-4.2	0.9
Respiratory disease	0.2	0.5	1.2	0.6	-0.0	-1.1
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.8	-2.6	0.4	1.9
Lung FEV1/FVC ratio	0.1	0.7	1.2	-0.6	0.8	-1.1
Lung FVC	2.5	12.6	25.7	2.8	5.1	-2.1
Neuroticism	0.1	0.3	0.3	-0.6	-0.6	0.3
Chronotype (morning person)	2.5	5.7	8.8	-2.8	-3.0	0.4
Hair Pigment	0.0	0.8	2.0	-0.7	-0.2	-1.4
Tanning	0.0	0.5	0.8	0.7	0.9	0.4
Hand grip strength (left)	0.9	2.4	3.6	1.9	1.1	-1.6
Number of treatments/medications taken	3.7	6.6	17.2	-4.2	-1.1	1.2
Average weekly spirits intake	0.6	0.7	2.2	-1.5	-0.0	0.1
Sensitivity / hurt feelings	0.3	0.6	1.1	-1.1	-0.0	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.4	-1.2	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.3	-0.5	-0.5
Relative age of first facial hair	0.5	1.0	1.5	0.8	1.0	-1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	-0.9	0.3	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.6	0.1	-1.0
Ever had hysterectomy (womb removed)	3.2	3.6	6.0	0.5	-2.2	-2.5
Systolic blood pressure, automated reading	1.1	3.1	3.7	-1.4	-1.9	1.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.1	1.1	0.7	-1.5
Angina	0.1	0.1	0.2	-0.2	0.5	-0.2
Medication for hormone replacement therapy	0.6	0.7	1.5	0.8	0.1	-1.2
Vitamin and mineral supplements	0.9	1.2	3.1	0.2	0.6	1.8
Supplements: Zinc	0.3	0.3	0.6	0.3	0.4	-0.8
Medication: Co-codamol	2.4	2.7	4.4	-2.1	-0.2	1.9
Medication: Metformin	2.1	3.0	5.8	-2.4	-1.3	1.2
Diabetes (father)	0.2	0.2	0.6	-0.8	0.1	-0.2
Diabetes (mother)	0.9	1.2	2.9	-0.7	-0.3	1.7
Severe depression (siblings)	0.1	0.1	0.2	0.2	-0.5	-0.1
Pack years adult smoking proportion	1.5	2.3	5.6	-0.9	-0.6	2.4
Impedance of leg (right)	2.6	12.7	31.1	2.5	0.9	-5.6
Leg fat-free mass (left)	6.1	32.3	72.9	-4.4	-2.2	8.5
Trunk fat percentage	12.5	50.1	106.1	-5.8	-3.3	10.3
Hand grip strength (right)	2.3	6.3	13.1	1.6	1.8	-3.6
Townsend deprivation index at recruitment	0.4	0.5	0.7	-0.6	0.9	0.7
Current tobacco smoking	1.9	3.2	4.3	-2.1	1.1	2.0
Average weekly fortified wine intake	1.4	1.6	2.5	-0.6	-1.6	-1.4
Maternal smoking around birth	0.0	0.0	0.1	-0.0	-0.1	0.3
Fed-up feelings	1.6	2.9	4.8	-1.9	-0.4	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	2.7	-1.6	-1.6	0.7
Relative age voice broke	0.2	0.2	0.6	0.8	0.2	-0.1
Taking other prescription medications	1.2	1.8	3.3	-1.8	-1.3	0.7
Age when periods started (menarche)	2.7	6.6	12.6	2.7	0.0	-3.5
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	2.6	-1.2	-1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	-0.9	-1.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.1	0.3	0.7	1.4
Qualifications: CSEs or equivalent	2.5	3.2	5.4	-1.1	-2.3	1.7
Serious illness, injury or assault to yourself	0.3	0.3	0.5	-0.7	-0.2	-0.7
High blood pressure	1.4	3.9	9.3	-3.1	-0.7	1.3
Hayfever, allergic rhinitis or eczema	3.2	6.9	17.4	1.8	-0.4	-4.2
Multivitamins +/- minerals	2.0	2.6	6.2	1.0	0.7	-2.5
Stomach or abdominal pain in last month	0.5	0.6	1.7	0.2	1.3	-0.0
Supplements: Glucosamine	0.5	0.7	1.1	-0.5	-1.0	-0.9
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.3	0.1	-0.0
Medication: Atenolol	1.1	1.3	3.5	0.0	-1.9	-0.7
Medication: Levothyroxine sodium	3.8	6.4	16.1	-1.4	-4.0	-1.0
Sitting height	0.1	0.7	1.5	-0.5	1.2	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.1	0.6	1.1
High blood pressure (mother)	0.7	1.0	2.3	1.5	-0.6	-0.4
Body mass index (BMI)	8.4	35.9	87.3	-4.1	-1.9	9.3
Impedance of leg (left)	2.3	11.3	29.2	2.0	0.7	-5.4
Leg predicted mass (left)	6.2	32.9	73.3	-4.5	-2.2	8.6
Trunk fat mass	12.7	54.5	118.8	-5.8	-3.3	10.9
Waist circumference	12.3	45.1	98.2	-5.5	-2.7	9.9
Number of incorrect matches in round	1.0	1.6	3.2	-1.8	-0.3	-1.3
Past tobacco smoking	2.1	3.9	9.3	-1.2	-3.0	1.0
Alcohol usually taken with meals	3.8	6.1	9.3	2.8	1.1	-3.0
Nervous feelings	2.3	4.3	9.0	-2.0	-3.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.7	0.3	-1.8	-2.2
Hearing difficulty/problems with background noise	1.2	1.9	5.1	0.8	-0.3	-2.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.0	-0.8	-0.8	-1.0
Had menopause	0.5	0.6	1.2	-0.8	-1.1	-0.1
Had other major operations	1.2	1.4	3.7	-0.6	-1.9	0.6
Forced vital capacity (FVC)	0.3	1.3	3.8	-0.1	2.0	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.9	-1.4	-0.6	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.4	-0.3	-0.6
Qualifications: None of the above	4.2	9.1	23.1	-1.9	-0.8	4.8
Financial difficulties in last 2 years	0.4	0.5	0.9	0.6	1.0	0.4
Mouth/teeth dental problems	0.6	1.0	2.3	0.2	-1.5	-0.8
Heart attack	1.3	1.6	4.0	-0.9	0.2	2.0
Allergy	1.3	3.0	7.0	-1.3	0.5	2.6
Pain all over the body in last month	0.4	0.5	0.6	-0.8	0.6	0.7
Diabetes (self-reported)	1.5	2.3	6.0	-2.5	-0.7	0.5
Hayfever/allergic rhinitis (self-reported)	4.1	5.5	10.5	1.1	-2.2	-3.2
Medication: Ramipril	1.3	1.7	2.6	-1.6	-1.4	0.8
Medication: Simvastatin	0.9	1.4	4.1	-2.0	-0.2	0.1
Fluid intelligence score	4.7	9.9	24.1	1.0	2.1	-4.9
Illnesses of siblings	0.9	1.3	3.5	1.9	0.5	-0.1
Neuroticism score	0.6	1.3	1.8	-1.3	-0.9	1.1
Weight	9.7	47.6	108.2	-5.3	-2.5	10.4
Impedance of arm (right)	0.5	2.5	3.8	-1.9	-1.7	0.9
Arm fat percentage (right)	13.3	52.4	118.8	-5.4	-3.0	10.9
Trunk fat-free mass	1.7	9.8	22.0	-2.5	-0.9	4.7
Hip circumference	12.6	54.2	125.4	-5.5	-2.7	11.2
Time employed in main current job	0.9	1.1	3.0	0.1	-1.7	-0.5
Alcohol intake versus 10 years previously	1.9	2.9	4.1	-2.0	0.7	2.0
Father’s age at death	0.5	0.7	1.4	0.7	-0.4	-1.2
Worrier / anxious feelings	0.6	1.1	1.4	-1.1	-1.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.3	10.0	-3.2	-1.6	0.6
Falls in the last year	0.4	0.6	1.1	-0.7	-0.4	-1.0
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	-0.1	0.7	0.8
Number of live births	5.2	7.3	21.4	0.8	-0.0	-4.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	0.0	2.2	-0.0
Pulse rate	1.0	1.6	2.2	-0.8	-1.5	-1.5
Happiness	3.4	4.1	8.2	2.9	0.5	-2.0
Noisy workplace	0.5	0.7	1.0	0.7	0.7	1.0
Qualifications: A levels/AS levels or equivalent	1.6	3.7	8.8	1.1	1.0	-3.0
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	6.2	2.1	0.9	-2.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.5	-0.3	1.9	1.6
Asthma	0.3	0.6	1.2	0.6	-0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-1.4	-0.6	0.2
Medication: Cholesterol lowering	0.9	1.4	3.1	-1.8	0.5	0.9
Depression (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.3
Medication: Lansoprazole	1.2	1.3	3.4	-0.6	0.4	1.9
Prospective memory result	0.5	0.7	1.4	-0.7	-1.2	0.1
Lung cancer (father)	1.1	1.3	2.7	0.4	-1.0	1.6
Illnesses of mother	0.3	0.4	0.8	-0.6	0.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	6.9	0.4	2.6	0.2
Pulse wave Arterial Stiffness index	2.1	2.5	4.2	1.2	1.4	-2.0
Impedance of arm (left)	0.5	2.4	3.9	-2.0	-1.8	0.3
Arm fat mass (right)	12.0	49.2	112.4	-5.2	-2.9	10.6
Trunk predicted mass	1.6	9.4	21.3	-2.5	-0.9	4.6
Standing height	0.8	8.1	12.0	-3.2	-1.6	3.5
Length of working week for main job	2.2	2.4	4.7	-2.2	-1.5	-0.3
Exposure to tobacco smoke at home	0.6	0.7	2.0	-1.4	-0.4	-0.1
Breastfed as a baby	2.7	3.3	7.2	2.7	0.8	-1.5
Tense / ‘highly strung’	0.2	0.4	0.9	0.6	0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.2	-0.3	-0.7
Hair/balding pattern: Pattern 4	1.0	2.4	6.9	0.3	0.3	-2.6
Birth weight of first child	1.5	2.8	7.5	0.5	-0.7	2.7
Peak expiratory flow (PEF)	0.5	1.2	3.0	-1.7	0.2	0.7
Pulse wave reflection index	2.1	2.6	4.8	1.6	2.2	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.3	0.8	1.1	-0.3
Loud music exposure frequency	0.5	0.6	1.3	1.2	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.9	-0.6	0.4	-2.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.0	0.0	0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	0.3	0.4
Medication: Paracetamol	4.3	7.2	9.8	-3.1	-1.5	3.1
Headache pain in last month	1.1	1.9	5.5	-2.3	-0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.1	2.0	0.9	-0.6
Glaucoma (self-reported)	0.1	0.2	0.5	0.1	0.7	-0.0
Gout (self-reported)	0.9	1.3	2.1	-1.3	-0.0	1.5
Hypothyroidism/myxoedema (self-reported)	3.5	6.8	17.0	-1.8	-4.1	0.3
Medication: Amlodipine	0.7	1.0	1.9	-1.4	-0.9	0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.3	-1.1	-1.1	0.4
Birth weight	1.1	2.4	6.5	-0.6	-0.5	2.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.2	0.0	-1.1	1.1
High blood pressure (siblings)	0.1	0.1	0.3	-0.3	-0.1	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.2	6.0	0.2	2.5	0.7
Body fat percentage	11.4	45.1	97.8	-5.4	-3.0	9.9
Leg fat percentage (right)	5.8	21.0	48.0	-3.4	-1.9	6.9
Arm fat-free mass (right)	2.1	10.6	25.6	-2.3	-0.9	5.1
Exposure to tobacco smoke outside home	1.4	1.8	4.0	-1.1	0.6	2.0
Comparative body size at age 10	5.0	13.8	29.3	-3.2	-1.4	5.4
Number of full brothers	0.4	0.5	1.3	-0.3	0.4	-1.1
Worry too long after embarrassment	0.9	1.6	4.7	-0.1	-0.1	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.9	1.7	0.7	-0.1
Wheeze or whistling in the chest in last year	1.5	2.6	4.9	-2.2	-0.7	1.6
Number of children fathered	0.6	0.7	1.7	0.4	0.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.8	0.8	0.2	-2.0
Age at first live birth	0.5	0.9	1.4	1.2	0.2	1.1
Pulse wave peak to peak time	2.6	3.0	5.9	-1.2	-1.3	2.4
Health satisfaction	0.2	0.2	0.6	0.4	-0.7	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.4	-0.5	-1.2	0.1
Qualifications: College or University degree	4.9	15.3	36.8	3.0	0.4	-6.1
Eye problems/disorders: None of the above	2.7	3.1	6.7	-0.0	-1.6	2.6
Mouth/teeth dental problems: Loose teeth	2.8	3.3	8.6	-2.9	-0.8	0.8
Emphysema/chronic bronchitis	2.6	2.9	4.5	-2.0	0.3	2.1
Medication for pain relief, constipation, heartburn	2.0	3.3	8.7	3.0	0.7	-0.9
Neck or shoulder pain in last month	0.3	0.5	0.9	-0.0	0.7	-0.9
Medication: Blood pressure	2.8	4.9	10.9	-3.3	-1.5	1.2
Angina (self-reported)	0.1	0.1	0.2	-0.3	0.4	-0.2
Migraine (self-reported)	0.6	0.7	1.2	0.8	0.5	-1.1
Medication: Ibuprofen	1.5	1.8	5.0	-2.2	-0.7	0.1
Medication: Allopurinol	1.2	1.6	3.7	-1.9	-0.1	1.0
Medication: Omeprazole	0.6	0.7	0.9	-0.9	0.7	0.9
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-1.5	0.1	-0.8
Mean time to correctly identify matches	3.0	5.8	10.5	-1.9	-1.8	-3.2
Heart disease (mother)	1.1	1.4	2.9	0.1	-1.1	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.5	-1.9	0.5	-0.3
Whole body fat mass	11.9	49.6	110.2	-5.5	-3.0	10.5
Leg fat mass (right)	8.7	33.7	80.1	-4.0	-2.2	8.9
Arm predicted mass (right)	2.1	11.0	25.4	-2.5	-1.1	5.0
Pulse rate, automated reading	2.1	6.6	11.8	-2.4	-3.4	-1.5
Alcohol intake frequency.	11.0	25.6	65.3	-3.3	-0.9	8.1
Comparative height size at age 10	3.3	18.3	29.5	-4.2	-2.8	5.4
Number of full sisters	1.8	2.1	4.8	1.0	0.8	-2.2
Suffer from ‘nerves’	7.3	11.5	19.4	-3.5	-1.7	4.4
Overall health rating	2.6	5.6	8.1	-2.8	-2.3	1.9
Chest pain or discomfort	0.7	1.0	2.3	-1.5	0.4	0.8
Had major operations	0.3	0.3	0.5	-0.3	0.6	-0.7
Age at last live birth	0.3	0.4	1.3	1.1	-0.1	0.0
Family relationship satisfaction	1.4	1.7	4.6	2.1	0.5	-0.6
Leg pain on walking	1.1	1.4	1.9	1.4	1.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	3.3	3.9	4.6	-2.1	2.1	1.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	-0.3	0.2	1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.8	-0.2	0.5
Medication: Aspirin	0.5	0.6	1.8	-0.2	0.2	-1.4
Supplements: Vitamin C	0.6	0.8	1.6	0.8	0.2	1.3
Knee pain experienced in last month	0.4	0.6	1.2	-1.1	-0.8	0.2
Hypertension (Self-reported)	1.6	4.5	10.7	-3.3	-0.3	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.2	1.1	1.5	0.1
Illnesses of father: Heart disease	0.2	0.3	0.9	0.9	0.3	0.1
Illnesses of siblings: Diabetes	2.5	3.1	8.1	-2.9	-1.0	-0.3
Smoking status: Previous	2.8	4.2	6.8	2.0	2.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	2.2	-1.4	-1.4	1.5
Whole body fat-free mass	3.2	18.1	40.7	-3.4	-1.4	6.4
Leg fat-free mass (right)	5.9	31.6	68.9	-4.6	-2.2	8.3
Arm fat percentage (left)	12.9	51.4	114.5	-5.5	-3.1	10.7
Average weekly red wine intake	1.9	2.8	5.5	1.1	1.3	-2.4
Handedness (chirality/laterality): Left-handed	3.1	3.8	10.5	-0.4	-0.8	3.2
Mood swings	0.4	0.7	1.0	-1.0	-0.5	1.0
Loneliness, isolation	1.9	2.6	4.3	-1.9	-0.3	2.1
Long-standing illness, disability or infirmity	2.3	3.5	5.1	-2.3	-1.2	2.0
Ever had bowel cancer screening	0.7	0.8	2.0	0.4	1.4	-0.5
Diabetes diagnosed by doctor	1.9	3.1	8.7	-2.9	-0.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.8	-0.5	0.9	-0.1
Friendships satisfaction	1.9	2.4	3.2	1.6	1.1	-1.8
Qualifications: nursing, teaching	1.8	2.8	6.9	1.2	-0.1	-2.6
Commuting to job workplace: Walk	0.1	0.1	0.2	0.2	-0.4	-0.2
Eye problems/disorders: Cataract	1.4	1.7	2.7	0.3	1.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	3.3	1.1	1.8	-1.5
Medication for cholesterol	0.4	0.6	0.7	0.7	-0.7	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.7	-2.4	-0.6	1.3
Back pain experienced in last month	0.2	0.3	0.6	-0.2	0.8	0.6
Mineral and other dietary supplements	0.4	0.6	1.0	0.5	0.8	1.0
Breast cancer (self-reported)	0.4	0.4	1.3	-1.1	0.1	-0.3
Asthma (self-reported)	0.2	0.3	0.6	0.6	-0.3	-0.8
Osteoporosis (self-reported)	0.3	0.3	0.5	0.7	0.7	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.2	-1.1	-0.3	0.3
Medication: Aspirin	0.3	0.3	1.0	0.0	-0.1	-1.0
Medication: Gliclazide	0.9	1.1	1.7	-1.3	-0.1	1.2
Illnesses of father: None of the above (group 1)	0.6	0.8	1.5	-0.7	-0.5	-1.2
Smoking status: Current	1.8	2.9	3.8	-1.9	1.1	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	5.2	2.3	1.9	-2.0
Whole body water mass	3.1	17.9	40.4	-3.4	-1.4	6.4
Leg predicted mass (right)	5.9	31.6	69.1	-4.6	-2.1	8.3
Arm fat mass (left)	11.9	49.0	112.4	-5.2	-2.7	10.6
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-1.1	-1.3	0.3
Average weekly champagne plus white wine intake	2.5	3.5	8.0	1.6	-0.2	-2.8
Miserableness	1.3	2.2	3.8	-1.9	-0.1	1.7
Guilty feelings	1.2	1.7	2.2	-1.4	-1.1	-1.5
Wears glasses or contact lenses	0.5	0.5	0.8	-0.2	-0.8	-0.9
Ever taken oral contraceptive pill	0.7	0.8	1.1	0.7	0.9	-1.1
Hearing aid user	0.1	0.1	0.3	-0.0	-0.2	0.6
Mother’s age at death	0.5	0.6	0.9	0.3	1.0	-0.9
Financial situation satisfaction	0.3	0.4	0.6	0.8	0.7	0.4
Tinnitus: Yes, now most or all of the time	3.2	3.7	5.7	0.7	-2.2	-2.4
Commuting to job workplace: Public transport	1.4	1.7	4.4	0.9	-0.0	-2.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.3	0.2	-0.7
Medication: Blood pressure	0.2	0.3	0.4	-0.6	0.6	0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.7	-1.9	-0.9	0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.9	-0.6	-1.4	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.4	-1.2	0.2	0.3
Medication: Bendroflumethiazide	1.5	2.2	6.1	-2.5	-0.8	0.1
Medication: Paracetamol	5.8	9.0	14.0	-3.1	-1.8	3.7
Medication: Lisinopril	2.7	3.5	4.7	-2.2	1.6	1.8
Medication: Atorvastatin	1.0	1.2	2.8	0.7	0.6	-1.7
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	0.6	-0.2
Alcohol drinker status: Never	3.4	4.0	9.2	-1.7	0.0	3.0
Ever smoked	1.9	3.4	7.6	0.6	2.8	-1.5
Basal metabolic rate	4.7	26.0	58.5	-4.0	-1.8	7.7
Leg fat percentage (left)	6.6	23.9	53.0	-3.8	-2.1	7.3
Arm fat-free mass (left)	2.6	13.3	30.2	-2.9	-1.2	5.5
Number of operations (self-reported)	0.7	1.1	1.9	-1.0	-1.4	-0.6
Average weekly beer plus cider intake	0.7	1.0	2.8	-0.1	0.2	1.7
Irritability	0.2	0.3	1.0	0.1	1.0	-0.0
Risk taking	1.4	2.1	3.5	1.7	1.9	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.6	0.1	0.1
Fractured/broken bones in last 5 years	2.0	2.5	4.8	-1.6	0.4	2.2
Age started oral contraceptive pill	1.1	1.4	2.5	-1.0	-1.6	-0.8
Diastolic blood pressure, automated reading	1.4	4.4	6.1	-2.1	-1.7	2.5
Ever depressed for a whole week	1.0	1.2	1.9	1.2	-0.5	-1.4
Unable to work because of sickness or disability	0.7	0.9	1.5	-1.2	-0.9	0.8
Commuting to job workplace: Cycle	1.7	2.0	3.2	-1.8	-0.5	-1.6
Myopia	0.3	0.5	0.6	0.6	0.8	-0.7
Vascular/heart problems diagnosed by doctor	1.2	3.4	8.1	2.8	0.5	-1.3
Cholesterol lowering medication	0.5	0.7	1.8	-0.4	-0.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.0	-1.7	0.9	1.2
Pain experienced in last month	0.1	0.1	0.2	0.4	0.2	0.4
Supplements: Calcium	2.7	3.0	8.0	0.4	-1.0	-2.8
Basal cell carcinoma (self-reported)	0.7	0.9	2.2	-1.5	-0.3	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.6	-0.9	0.1	1.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.3	0.4	0.4
Heart disease (siblings)	0.2	0.3	0.3	-0.5	0.6	-0.5
Alcohol drinker status: Previous	1.5	1.7	3.1	-1.4	-0.2	1.7
Pack years of smoking	1.1	1.6	4.4	-0.5	-0.0	2.1
Impedance of whole body	0.5	2.3	6.7	0.2	-0.5	-2.6
Leg fat mass (left)	9.2	35.8	83.5	-4.3	-2.4	9.1
Arm predicted mass (left)	2.5	12.9	29.8	-2.8	-1.1	5.5