Hub : Genes

CLTB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1984	0.0543	2.9e-06	0.116	NA	0.124	NA	0.129	3.5e-09	NA	1.0e-09	NA	4.8e-10
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1260	0.0480	2.2e-03	0.041	NA	0.001	NA	0.020	2.7e-03	NA	2.6e-01	NA	2.8e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1820	0.0520	4.8e-06	0.049	NA	0.078	NA	0.061	6.7e-05	NA	4.7e-07	NA	9.3e-06
4	GTEx	Whole Blood	0.0640	0.0250	2.0e-03	0.054	NA	0.045	NA	0.057	9.5e-06	NA	5.3e-05	NA	6.1e-06
5	NTR	Blood	0.0217	0.0092	2.4e-03	0.018	0.008	0.019	0.010	0.012	1.0e-06	1.1e-03	4.8e-07	2.5e-04	4.7e-05
6	ROSMAP	Brain Pre-frontal Cortex	0.0367	0.0157	4.6e-03	0.007	0.016	0.010	0.014	0.008	3.5e-02	3.3e-03	1.7e-02	5.2e-03	3.0e-02
7	YFS	Blood	0.1721	0.0280	0.0e+00	0.127	0.177	0.183	0.175	0.170	2.1e-39	1.1e-55	1.7e-57	9.9e-55	2.2e-53

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.8	2.8	6.0	0.0	-1.1	-2.4	-1.8	-2.0	1.0	-2.1
Bipolar Disorder or Schizophrenia	0.9	2.2	8.2	0.0	-2.9	-2.1	-0.6	-1.0	0.8	-1.1
Depressed Affect (Nagel 2018)	3.0	6.2	12.2	1.0	3.5	2.9	2.2	0.8	-3.4	2.1
Depression (Nagel 2018)	2.5	3.8	7.5	0.0	1.5	2.3	2.1	1.4	-2.7	2.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.4	0.9	1.3	1.9	0.5	-1.5	-0.7	0.0
Neuroticism (Nagel 2018)	2.4	5.6	9.0	-0.2	2.2	2.5	3.0	1.6	-3.0	2.8
Schizophrenia (2018)	0.6	1.3	7.9	0.0	-2.8	-0.8	0.7	0.4	0.2	0.3
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	0.0	-1.1	0.6	1.5	1.6	-0.6	1.6
Worry (Nagel 2018)	0.5	1.1	1.8	-1.1	-0.9	0.9	1.3	1.0	-0.7	1.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.9	1.4	-0.0	-0.7	0.4	-0.2	0.7	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.4	0.5	0.5	0.6	0.2	0.1	0.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	1.3	-0.1	-0.1	1.0	0.7	0.6	0.4
Crohns Disease (2017)	0.4	1.0	1.7	-0.4	0.7	1.2	1.3	-0.0	-1.1	1.3
Irritable Bowel Disease (IBD)	0.8	1.8	3.9	-0.3	1.1	1.8	1.4	0.5	-2.0	1.5
Ulcerative Colitis (UC)	0.4	0.8	2.3	-0.1	0.0	0.8	0.9	1.0	-1.5	1.0
Major Depression (MDD)	0.9	1.1	3.4	0.0	1.8	0.0	-1.1	0.0	0.0	-1.7
Reaction Time	1.4	2.7	5.7	-1.3	-1.4	-0.7	-1.2	-2.2	1.7	-2.4
Verbal and Numeric Reasoning (VNR)	1.0	2.4	6.9	0.3	2.1	2.6	0.7	-1.9	-1.1	0.3
Breast Cancer	0.4	1.1	4.6	-2.1	-1.1	0.2	-0.8	-0.6	0.2	-0.8
Ovarian Cancer	0.3	0.4	1.3	0.6	1.1	0.7	0.2	0.3	-0.1	0.9
Prostate Cancer	0.2	0.3	1.5	-0.6	-1.2	0.2	0.3	0.2	-0.1	0.4
Age at First Birth	3.3	4.7	9.8	-0.1	-1.2	-1.3	-2.2	-2.5	3.1	-3.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	2.5	0.0	-0.2	-0.8	-0.8	1.6	0.2	0.2
Coronary Artery Disease (CAD)	3.4	4.0	7.6	0.0	-0.7	1.4	2.4	2.7	-2.2	2.8
Crohns Disease (2012)	0.4	0.7	1.4	0.0	-0.2	0.5	0.8	1.2	-1.1	1.1
Mean Putamen Volume	0.1	0.1	0.2	0.0	-0.5	0.4	-0.0	0.0	0.3	0.0
Fasting Glucose	0.5	0.6	2.3	1.2	1.5	0.7	-0.1	-0.6	0.0	-0.2
HbA1C	0.3	0.4	1.0	0.0	-1.0	-0.4	-1.0	0.2	0.7	0.0
HDL Cholesterol	0.3	0.5	1.3	0.0	-0.2	-1.0	0.0	-1.1	0.8	-0.7
LDL Cholesterol	1.1	1.8	5.0	0.0	-1.0	-2.2	-1.9	-0.7	1.0	-1.2
Lupus	0.4	0.6	1.1	0.9	0.6	0.7	-0.8	-0.2	0.8	-1.1
Neuroticism (2016)	0.5	0.7	1.4	0.5	1.2	0.8	0.7	-1.1	-0.8	0.6
Primary Biliary Cirrhosis	0.4	0.6	1.8	0.0	-0.7	0.4	0.8	1.4	0.0	1.0
Rheumatoid Arthritis	0.2	0.2	0.7	0.0	-0.1	-0.8	-0.2	-0.8	0.3	-0.4
Schizophrenia (2014)	1.2	2.6	11.2	0.0	-3.4	-2.4	0.3	0.2	0.7	-0.5
Triglycerides	0.4	0.7	2.0	0.0	0.4	1.4	0.5	-0.7	-1.3	0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.9	0.0	-1.3	-1.4	0.1	0.8	0.1	-0.1
Ulcerative Colitis	1.0	1.5	3.2	0.0	1.4	1.2	1.4	0.3	-1.8	1.3
Blood Eosinophil Count	0.1	0.9	1.8	1.4	0.2	-1.2	0.9	-1.1	0.9	0.4
Blood Platelet Count	0.2	2.1	4.8	1.5	-1.0	-2.2	-1.0	-1.5	1.8	-0.5
Blood Red Count	0.5	5.3	12.0	2.6	-0.6	-0.6	-2.5	-2.7	2.1	-3.5
Blood White Count	0.1	0.8	2.7	1.6	1.3	0.6	-0.2	-0.7	-0.6	-0.4
Heel T-Score	0.2	1.9	4.5	0.1	-0.3	-0.7	-2.1	-1.6	1.8	-1.5
BMI	0.4	2.5	3.8	1.8	1.9	1.9	-1.9	-0.6	-0.9	-1.5
Height	1.0	18.7	64.2	-1.4	-8.0	-5.6	-2.8	0.1	4.9	-1.3
Waist Hip Ratio (WHR)	0.2	0.7	1.2	1.1	-1.1	-0.3	0.5	1.0	-0.4	1.0
Systolic Blood Pressure	0.4	2.0	5.7	1.6	0.0	-0.7	-2.4	-0.6	1.1	-1.9
Smoking Status	0.8	2.0	4.1	1.2	2.0	2.0	0.6	-0.1	-2.0	0.1
Allergy or Eczema	0.2	0.4	2.0	-0.1	1.4	0.4	0.6	-0.3	-0.7	-0.0
Cardiovascular Disease	0.2	0.8	1.6	0.8	0.8	0.4	-1.0	-0.8	1.0	-1.3
Hypothyroidism (self reported)	0.4	0.9	1.8	1.1	0.4	1.1	0.5	1.3	-0.9	1.0
Respiratory disease	0.3	0.8	3.4	1.8	0.3	-0.4	-0.2	-0.3	1.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.5	0.9	1.2	0.8	-1.0	-1.1	0.3	-0.8
Lung FEV1/FVC ratio	0.6	3.0	7.8	0.2	2.8	2.8	-0.5	-0.5	-2.3	0.1
Lung FVC	0.2	0.8	2.1	-0.2	0.4	1.4	0.8	-1.1	-1.3	0.4
Neuroticism	2.6	6.3	11.1	-1.3	1.6	2.7	3.1	1.7	-3.3	3.0
Chronotype (morning person)	0.2	0.4	1.3	-0.7	0.4	-0.2	-1.0	-0.2	1.1	-0.2
Hair Pigment	0.0	1.0	2.9	-1.2	-1.6	-0.3	0.1	1.7	-0.1	-0.3
Tanning	0.1	0.9	2.7	0.6	1.6	1.3	-0.8	0.7	0.0	0.3
Hand grip strength (left)	0.4	1.0	4.9	-2.2	-0.3	-0.3	-0.5	-0.8	-0.1	-0.8
Number of treatments/medications taken	1.9	3.5	8.4	2.2	2.0	2.9	0.8	0.8	-2.1	1.2
Average weekly spirits intake	0.9	1.2	4.0	1.2	2.0	1.0	0.0	0.3	-1.2	0.3
Sensitivity / hurt feelings	0.6	1.0	2.0	-0.5	0.9	0.7	0.4	1.3	-1.4	1.3
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.8	-1.0	0.7	1.8	2.0	0.8	-1.9	2.2
Hearing difficulty/problems: Yes	1.3	2.0	5.4	0.6	0.6	0.9	2.3	1.6	-1.0	1.8
Relative age of first facial hair	0.3	0.7	1.4	1.2	-0.8	-0.2	-0.8	-0.9	1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	6.8	0.8	2.2	2.6	1.1	0.9	-2.2	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	0.2	-1.1	0.7	0.8	0.0	0.2	0.5
Ever had hysterectomy (womb removed)	1.9	2.1	5.3	0.4	0.7	0.6	1.2	2.3	-2.1	1.7
Systolic blood pressure, automated reading	0.4	1.1	4.2	2.1	0.7	-0.3	-1.0	-0.8	0.4	-1.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.9	1.7	-0.6	-0.4	-1.5	-1.0	0.9	-0.9
Angina	0.3	0.4	0.7	0.6	0.9	0.6	0.6	-0.6	-0.8	0.2
Medication for hormone replacement therapy	0.7	0.8	1.3	0.6	0.9	1.1	1.0	0.6	-1.0	0.9
Vitamin and mineral supplements	0.2	0.3	1.1	0.7	0.2	-0.4	-0.3	1.1	-0.3	0.1
Supplements: Zinc	0.4	0.4	1.1	0.4	1.0	-0.3	-0.5	-0.9	0.6	-0.3
Medication: Co-codamol	0.7	0.8	1.5	0.7	1.1	1.2	1.2	-0.5	-0.3	0.2
Medication: Metformin	0.4	0.5	2.1	0.5	-0.6	-0.0	0.5	-0.8	1.4	-0.0
Diabetes (father)	0.6	0.8	2.0	-1.2	-0.9	-0.8	-0.0	-0.8	1.4	-0.1
Diabetes (mother)	0.4	0.5	1.5	0.1	1.2	-0.6	-0.5	-1.1	0.0	-0.5
Severe depression (siblings)	1.1	1.2	3.5	0.1	1.7	1.9	0.1	-0.7	-0.2	-1.2
Pack years adult smoking proportion	0.5	0.8	1.7	0.9	-0.1	0.7	1.3	0.8	-0.7	1.1
Impedance of leg (right)	0.1	0.7	2.3	-0.2	-1.5	-0.5	-0.3	1.1	0.5	0.6
Leg fat-free mass (left)	0.2	1.3	3.5	-0.0	-0.5	-1.0	-1.9	-1.0	0.7	-1.7
Trunk fat percentage	0.5	1.9	6.5	1.9	-0.7	0.2	-2.5	0.3	0.4	-1.5
Hand grip strength (right)	0.2	0.6	2.2	-1.5	-0.1	0.2	-0.6	-0.7	-0.0	-1.0
Townsend deprivation index at recruitment	1.0	1.4	2.5	1.2	-1.2	-1.6	1.4	0.5	0.2	1.3
Current tobacco smoking	2.6	4.3	8.9	0.4	2.2	1.9	2.7	1.3	-3.0	1.9
Average weekly fortified wine intake	0.4	0.5	1.8	1.3	0.6	-0.3	-0.4	0.6	-0.6	0.4
Maternal smoking around birth	0.3	0.4	0.8	0.3	-0.8	-0.3	0.4	0.9	0.8	0.4
Fed-up feelings	1.9	3.5	7.9	0.8	2.2	2.0	1.8	1.4	-2.8	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.8	9.8	0.4	0.9	1.7	2.2	1.9	-3.1	2.2
Relative age voice broke	0.2	0.2	0.8	0.1	-0.1	-0.4	-0.8	-0.9	-0.2	-0.3
Taking other prescription medications	1.9	3.0	7.8	0.4	1.4	2.8	1.8	0.8	-2.0	1.8
Age when periods started (menarche)	0.1	0.2	0.7	-0.9	0.5	0.5	-0.2	-0.2	-0.4	0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.4	1.0	1.5	0.9	-0.8	0.5	-0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-1.0	-0.3	-0.2	-0.6	0.8	-0.8	-0.4
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	8.7	0.0	-1.3	-0.2	0.1	-3.0	1.4	-1.2
Qualifications: CSEs or equivalent	1.3	1.7	2.8	1.4	0.0	-0.9	-1.2	-1.6	1.7	-1.6
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.8	-0.0	0.3	-0.5	-0.2	-0.2	-0.6
High blood pressure	0.2	0.7	2.5	0.4	0.5	0.1	-0.5	-1.6	1.0	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.3	0.1	1.4	1.4	1.2	1.0	-1.5	0.7
Multivitamins +/- minerals	0.3	0.3	0.7	-0.7	-0.5	0.2	-0.1	-0.8	0.7	-0.6
Stomach or abdominal pain in last month	0.3	0.3	1.3	0.6	1.1	0.4	0.1	-0.6	0.0	0.0
Supplements: Glucosamine	2.2	2.8	8.6	1.1	2.7	2.9	0.1	-0.2	-1.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.7	1.6	0.7	0.1	-0.8	-0.0	0.1	-0.6
Medication: Atenolol	0.1	0.1	0.4	-0.3	0.0	0.4	0.4	0.6	-0.1	0.5
Medication: Levothyroxine sodium	0.8	1.4	3.0	1.7	1.1	1.2	0.6	1.2	-0.8	1.3
Sitting height	0.3	2.1	4.8	-1.3	-2.2	-1.9	-1.4	-0.3	1.1	-0.8
Chronic bronchitis/emphysema (father)	3.2	3.8	8.8	-0.5	-0.6	0.1	2.8	2.5	-1.6	3.0
High blood pressure (mother)	1.1	1.5	2.8	1.1	0.9	0.9	-1.1	-1.3	1.7	-1.5
Body mass index (BMI)	0.4	1.6	2.8	1.6	1.2	0.7	-1.7	-0.9	-0.4	-1.7
Impedance of leg (left)	0.2	0.9	4.1	0.2	-2.0	-0.6	-0.2	1.0	0.7	0.3
Leg predicted mass (left)	0.3	1.5	3.9	0.1	-0.4	-1.0	-2.0	-1.1	0.8	-1.9
Trunk fat mass	0.5	2.2	7.7	1.7	-0.8	-0.2	-2.8	-0.1	0.7	-1.9
Waist circumference	0.6	2.0	5.4	2.3	-0.7	-0.6	-1.9	-0.6	0.8	-1.8
Number of incorrect matches in round	0.2	0.4	1.1	-0.3	-0.6	-0.9	-0.6	-0.1	1.0	-0.4
Past tobacco smoking	0.7	1.3	4.6	-0.5	-1.2	-2.1	-0.0	0.8	1.4	-0.2
Alcohol usually taken with meals	2.8	4.5	9.8	1.7	0.3	-0.7	-3.1	-2.3	2.4	-2.8
Nervous feelings	0.6	1.1	4.6	-2.1	-1.5	0.7	0.5	0.1	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	3.2	4.9	10.7	-0.6	0.3	2.5	3.3	1.4	-2.8	2.7
Hearing difficulty/problems with background noise	1.2	1.9	4.1	-0.7	0.7	0.3	2.0	2.0	-1.2	1.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	1.1	-0.0	0.3	0.2	0.6	0.5	0.6
Had menopause	1.3	1.6	4.2	0.0	-1.6	-0.8	-0.3	-1.8	2.1	-0.9
Had other major operations	1.3	1.6	5.1	-0.1	1.3	2.3	0.9	1.2	-1.4	0.7
Forced vital capacity (FVC)	0.2	0.8	1.7	-1.0	-1.3	-0.4	-0.9	-0.8	0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-1.1	-0.5	-0.4	-0.9	0.6	-0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.9	1.7	0.8	1.0	0.3	-0.7	0.2	-1.0
Qualifications: None of the above	2.2	4.7	11.5	-0.7	-0.6	0.5	1.9	3.4	-3.0	2.7
Financial difficulties in last 2 years	0.5	0.7	2.2	1.0	-0.5	-0.1	-0.2	-0.4	1.3	-1.5
Mouth/teeth dental problems	0.8	1.3	3.4	-1.8	-1.8	-1.3	0.4	0.5	0.3	0.5
Heart attack	0.9	1.1	5.1	-0.4	2.3	0.9	-0.4	-0.6	-1.0	-0.1
Allergy	0.1	0.3	2.0	-0.5	-1.4	-0.1	0.0	-0.3	0.0	0.2
Pain all over the body in last month	0.6	0.7	1.5	-0.8	0.4	0.5	0.6	0.8	-1.1	1.2
Diabetes (self-reported)	0.4	0.7	2.8	1.7	0.9	0.8	0.1	-0.3	0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.4	-0.7	-0.3	0.8	0.8	-0.6	0.6
Medication: Ramipril	1.7	2.1	7.4	0.2	-0.7	-1.2	-0.6	-2.7	1.9	-1.4
Medication: Simvastatin	0.1	0.2	0.4	-0.2	-0.0	0.6	0.5	0.5	-0.3	0.4
Fluid intelligence score	0.6	1.3	4.6	0.2	0.8	0.4	-0.6	-2.1	1.0	-1.5
Illnesses of siblings	1.4	2.0	4.2	-2.1	-0.2	-0.3	1.8	1.9	-1.1	1.3
Neuroticism score	1.6	3.3	6.9	-0.6	0.8	1.8	2.6	1.3	-2.4	2.2
Weight	0.5	2.3	7.1	1.0	-1.0	-1.0	-2.7	-0.6	0.9	-2.2
Impedance of arm (right)	0.2	0.9	2.5	-0.6	-1.6	-0.7	-0.2	1.3	0.6	0.7
Arm fat percentage (right)	0.4	1.4	4.6	1.4	0.4	0.3	-2.2	-0.5	0.1	-1.8
Trunk fat-free mass	0.3	2.0	3.1	-0.3	-1.4	-1.7	-1.8	-1.2	1.3	-1.7
Hip circumference	0.9	3.7	9.2	1.3	-1.5	-1.2	-3.0	-1.1	1.7	-2.7
Time employed in main current job	0.6	0.6	1.5	1.2	-0.5	-1.2	-0.7	0.8	-0.2	-0.1
Alcohol intake versus 10 years previously	0.7	1.0	3.7	-1.3	-1.9	-0.6	0.7	-0.1	0.9	0.5
Father’s age at death	1.3	1.7	3.7	0.5	0.9	-0.5	-1.7	-1.7	1.2	-1.9
Worrier / anxious feelings	0.9	1.6	3.3	-1.8	0.4	0.1	1.5	1.1	-1.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	7.0	0.2	1.5	2.6	2.2	1.3	-2.5	2.5
Falls in the last year	0.2	0.3	0.9	0.5	-0.8	0.1	1.0	-0.2	0.3	0.6
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	1.3	0.2	-0.6	-0.6	1.3	-0.8	0.3
Number of live births	1.5	2.2	5.4	-0.8	-1.3	-2.3	-1.2	-0.7	1.8	-1.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.8	-0.9	-1.1	-0.4	-1.2	-1.1	0.9	-1.3
Pulse rate	1.8	3.1	6.9	1.3	2.6	2.0	1.3	-1.6	-2.2	0.4
Happiness	0.6	0.7	1.7	-0.7	-0.8	-1.3	0.8	0.9	-0.5	0.7
Noisy workplace	3.1	3.8	8.4	1.0	0.6	0.6	2.4	2.3	-2.9	2.3
Qualifications: A levels/AS levels or equivalent	2.0	4.3	9.9	-1.5	-0.7	-0.7	-2.0	-3.1	2.9	-2.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.3	1.2	-0.1	-1.1	-2.1	-0.9	1.3	-1.5
Mouth/teeth dental problems: Dentures	1.0	1.6	3.2	1.7	1.8	1.1	0.5	0.5	-1.7	0.7
Asthma	0.7	1.4	2.7	1.3	-0.1	-1.6	-1.6	-0.4	1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.6	0.8	0.5	-0.4	-0.0	0.5	-0.8
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.4	0.2	1.0	0.7	-0.6	0.5	-0.0
Depression (self-reported)	1.2	1.4	4.8	-2.2	0.9	0.9	1.1	0.6	-1.1	0.7
Medication: Lansoprazole	1.2	1.3	3.5	-0.2	-1.9	-1.6	-1.0	0.2	1.3	-0.7
Prospective memory result	0.5	0.6	2.6	-1.6	0.6	-0.5	0.2	-0.5	-0.5	0.5
Lung cancer (father)	0.4	0.5	1.2	0.8	0.6	0.3	-0.7	0.1	0.9	-1.1
Illnesses of mother	1.8	2.2	3.7	-1.3	-0.5	-1.0	1.3	1.8	-1.9	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.9	-0.3	-0.1	0.1	-0.4	-0.5	-0.0	-0.9
Pulse wave Arterial Stiffness index	0.9	1.1	5.8	2.4	0.1	0.4	-0.9	-0.6	-0.5	-0.1
Impedance of arm (left)	0.2	0.8	2.3	-0.4	-1.3	-0.4	0.0	1.5	0.4	0.9
Arm fat mass (right)	0.4	1.5	4.7	1.4	0.1	0.2	-2.2	-0.7	0.2	-1.9
Trunk predicted mass	0.3	1.9	3.0	-0.4	-1.2	-1.7	-1.7	-1.2	1.2	-1.7
Standing height	0.6	6.3	21.1	-1.1	-4.6	-3.3	-1.9	1.0	2.4	-0.6
Length of working week for main job	1.2	1.3	3.0	0.3	-1.1	-1.3	-1.1	-0.6	1.7	-1.1
Exposure to tobacco smoke at home	1.1	1.2	3.5	0.9	1.3	0.8	0.4	1.2	-1.9	0.4
Breastfed as a baby	0.2	0.3	0.7	0.6	0.5	0.6	0.2	0.3	-0.8	-0.0
Tense / ‘highly strung’	1.7	2.9	8.3	-0.7	-0.7	0.7	2.5	1.8	-0.9	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.1	-1.2	1.6	2.0	0.8	-0.9	-1.1	-0.2
Hair/balding pattern: Pattern 4	0.1	0.4	0.8	-0.8	-0.1	0.2	0.6	-0.9	-0.0	-0.8
Birth weight of first child	0.2	0.3	1.0	0.2	1.0	0.2	-0.1	0.5	-0.6	-0.5
Peak expiratory flow (PEF)	0.4	1.0	1.6	-1.0	-1.1	-0.0	-1.3	-0.7	1.2	-1.3
Pulse wave reflection index	0.3	0.3	1.5	0.3	-0.3	0.0	-0.4	1.2	-0.2	0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.8	1.2	1.1	1.1	-0.4	-0.1	-1.0	-1.4
Loud music exposure frequency	0.8	0.8	1.3	-1.1	0.1	-0.0	1.1	1.1	-0.9	1.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	7.3	-0.6	0.4	-1.0	-1.5	-2.7	2.5	-2.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.5	0.9	-0.6	-0.3	-1.0	-1.1	1.9	-1.3
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.2	0.5	0.5	0.6	-0.1	-0.2	0.4
Medication: Paracetamol	0.7	1.2	5.0	0.7	1.2	2.2	-1.0	-0.1	-0.4	-0.3
Headache pain in last month	0.7	1.2	3.6	1.5	1.9	0.8	-0.3	-0.3	-1.2	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	5.2	-0.2	-0.9	-2.3	-1.5	0.4	1.0	-0.7
Glaucoma (self-reported)	0.9	1.1	2.7	1.0	1.1	-0.5	-1.6	-0.5	-0.6	-1.3
Gout (self-reported)	4.3	5.9	12.7	-3.1	1.2	1.0	2.6	1.8	-3.6	2.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	0.7	0.5	0.5	0.8	0.9	-0.5	1.1
Medication: Amlodipine	0.2	0.2	0.8	-0.3	-0.5	-0.2	-0.0	0.3	0.9	0.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.5	1.3	1.9	1.1	-0.6	0.1	-1.6	-0.3
Birth weight	0.6	1.4	4.2	-1.8	-2.0	-1.2	0.6	0.4	0.4	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	0.3	0.2	0.9	0.6	-0.8	0.7	-0.1
High blood pressure (siblings)	0.5	0.7	2.0	1.4	-0.2	-0.0	-1.4	-0.7	0.2	-0.5
Forced vital capacity (FVC), Best measure	0.0	0.2	0.5	-0.5	-0.7	-0.1	-0.2	-0.2	-0.2	-0.6
Body fat percentage	0.5	2.0	6.8	2.0	-0.2	0.3	-2.6	-0.0	0.3	-1.8
Leg fat percentage (right)	0.4	1.5	5.0	1.6	0.4	0.4	-2.2	-0.3	0.1	-1.6
Arm fat-free mass (right)	0.4	2.3	4.8	0.4	-0.9	-1.4	-2.2	-1.4	1.2	-2.2
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.4	-0.0	-0.6	0.1	0.0	-0.0	0.5
Comparative body size at age 10	0.6	1.7	2.9	-1.7	1.5	0.7	0.8	-1.6	-1.6	-0.4
Number of full brothers	0.3	0.4	1.1	0.8	0.2	1.0	0.8	0.3	-0.7	0.0
Worry too long after embarrassment	1.6	2.6	5.5	-0.5	1.5	1.4	2.4	1.1	-1.9	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.4	-1.6	-0.8	0.1	1.1	0.4	-0.2	1.1
Wheeze or whistling in the chest in last year	0.9	1.7	4.6	2.1	0.5	0.1	0.7	1.3	-1.7	1.2
Number of children fathered	1.5	1.7	4.3	1.1	-0.5	-0.1	-1.8	-0.9	1.4	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.4	-0.2	-0.6	1.1	0.1	-0.4	1.1
Age at first live birth	1.1	2.0	7.8	-1.5	-0.4	0.7	-0.3	-2.8	1.6	-0.9
Pulse wave peak to peak time	1.0	1.2	5.9	-2.4	-0.5	-0.9	0.6	0.7	0.7	-0.1
Health satisfaction	0.4	0.5	1.2	1.0	-0.8	-0.2	-1.1	0.6	0.3	-0.5
Shortness of breath walking on level ground	1.7	2.0	4.8	2.2	1.5	1.7	-0.0	1.3	-1.6	0.5
Qualifications: College or University degree	0.6	2.0	6.3	-2.5	-0.5	-1.0	0.5	-2.1	1.4	0.0
Eye problems/disorders: None of the above	1.7	1.9	4.5	-1.6	-2.0	-0.4	0.5	0.9	2.1	1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.1	0.6	-0.9	-1.8	0.5	0.9	0.9	0.0
Emphysema/chronic bronchitis	0.6	0.7	2.4	1.1	-0.1	-0.9	-0.1	-0.2	1.6	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	1.2	-1.0	-0.7	-0.8	1.1	-0.2	-0.4	0.5
Neck or shoulder pain in last month	1.2	1.7	3.0	1.7	1.5	1.3	0.0	1.4	-1.7	0.4
Medication: Blood pressure	0.1	0.2	0.7	-0.3	0.2	0.7	0.9	-0.3	-0.3	0.1
Angina (self-reported)	0.4	0.5	1.0	0.8	1.0	0.6	0.6	-0.6	-0.8	0.2
Migraine (self-reported)	2.3	2.8	8.2	1.3	2.9	2.7	-0.8	-1.0	-0.5	-0.7
Medication: Ibuprofen	0.1	0.1	0.3	0.4	0.6	0.2	-0.1	0.4	-0.1	-0.4
Medication: Allopurinol	5.6	7.4	14.1	-2.8	1.4	1.4	3.3	2.3	-3.8	3.1
Medication: Omeprazole	0.6	0.7	2.9	1.7	0.6	0.9	-0.7	-0.2	-0.2	-0.0
Medication: Seretide 50 evohaler	0.7	0.8	2.2	1.3	-0.8	-0.5	-0.8	-0.5	1.5	-0.5
Mean time to correctly identify matches	0.5	1.0	3.5	-0.9	-0.7	0.3	-0.4	-1.9	0.9	-1.2
Heart disease (mother)	0.6	0.7	1.4	1.0	0.4	0.7	-1.1	-1.2	0.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.7	0.6	0.0	-0.6	-0.4	-0.2	-0.3
Whole body fat mass	0.5	2.0	6.4	1.8	-0.3	0.1	-2.5	-0.4	0.5	-2.0
Leg fat mass (right)	0.5	1.8	5.6	1.7	0.0	0.2	-2.4	-0.5	0.4	-2.0
Arm predicted mass (right)	0.5	2.3	4.6	0.0	-1.1	-1.5	-2.1	-1.4	1.4	-2.1
Pulse rate, automated reading	1.4	4.4	9.1	1.8	2.0	1.9	3.0	0.1	-3.0	1.5
Alcohol intake frequency.	0.3	0.6	1.3	1.1	0.4	0.8	0.2	0.8	-0.7	1.0
Comparative height size at age 10	0.5	2.6	7.5	-0.5	-2.7	-2.7	-0.8	1.3	0.9	0.0
Number of full sisters	0.6	0.8	3.4	-0.1	0.3	-0.6	0.4	1.8	-1.0	0.6
Suffer from ‘nerves’	0.4	0.7	2.6	0.1	-0.5	1.6	0.5	0.3	-1.1	0.5
Overall health rating	1.4	2.9	6.7	1.3	1.7	2.3	1.1	1.2	-2.6	0.9
Chest pain or discomfort	0.7	1.0	3.4	1.8	0.6	0.9	0.3	-0.6	-1.4	-0.0
Had major operations	0.5	0.6	2.0	0.4	0.6	1.4	0.7	-0.3	-0.9	-0.0
Age at last live birth	0.4	0.6	1.9	-1.4	-0.7	-0.5	0.6	-1.0	0.6	-0.1
Family relationship satisfaction	0.6	0.8	3.7	-0.0	-1.0	-1.9	0.3	0.1	0.7	0.3
Leg pain on walking	0.8	1.0	4.4	-0.5	0.7	0.8	0.2	1.0	-2.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.4	0.7	0.5	-0.9	0.9	0.3	-0.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.6	1.3	1.0	1.6	-1.9	0.0	0.2	-1.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.3	-0.0	-0.1	0.8	0.5	0.2	0.8
Medication: Aspirin	0.6	0.8	2.8	-0.1	1.7	1.2	0.2	-0.2	-1.0	0.4
Supplements: Vitamin C	0.3	0.3	1.0	-0.7	0.5	-0.2	-0.1	-1.0	0.5	-0.5
Knee pain experienced in last month	0.5	0.8	2.2	1.1	-0.2	0.2	-1.5	-0.6	0.5	-1.3
Hypertension (Self-reported)	0.2	0.7	2.1	0.8	0.9	-0.1	-0.3	-1.5	0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.1	1.3	-2.0	-2.2	-0.4	0.5	1.6	-0.3
Illnesses of father: Heart disease	1.1	1.5	5.7	1.2	2.4	1.0	-0.3	-1.6	0.1	-0.2
Illnesses of siblings: Diabetes	1.3	1.6	4.7	0.9	0.9	1.0	-1.4	-2.2	0.9	-1.2
Smoking status: Previous	0.5	0.8	1.5	1.2	0.7	1.2	-0.9	-1.1	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.4	-2.1	-0.8	-0.6	-0.8	0.5	0.6	-0.3
Whole body fat-free mass	0.3	1.9	3.9	-0.1	-1.0	-1.5	-2.0	-1.1	1.1	-1.9
Leg fat-free mass (right)	0.3	1.6	4.1	0.2	-0.6	-1.1	-1.9	-1.1	0.9	-2.0
Arm fat percentage (left)	0.4	1.7	4.8	1.6	0.6	0.7	-2.2	-0.5	0.1	-1.8
Average weekly red wine intake	0.4	0.7	1.6	0.1	0.3	-0.3	-1.2	-1.3	0.7	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	-1.2	-0.6	-0.3	0.3	-0.9	0.8	-0.0
Mood swings	1.5	2.7	6.8	0.2	1.9	2.0	1.5	1.0	-2.6	1.1
Loneliness, isolation	3.8	5.2	11.8	-0.0	-0.7	1.5	3.2	2.6	-2.2	3.4
Long-standing illness, disability or infirmity	1.1	1.6	5.0	2.2	1.0	1.6	0.4	0.9	-1.2	0.7
Ever had bowel cancer screening	2.1	2.5	7.2	2.7	2.2	2.2	0.1	-0.6	-0.2	0.3
Diabetes diagnosed by doctor	0.3	0.5	1.1	1.1	0.9	0.9	0.5	0.1	-0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	0.1	-0.3	-0.5	0.1	-1.2	1.4	-0.9
Friendships satisfaction	0.9	1.2	2.6	-0.5	-1.2	-0.7	1.3	1.6	-0.7	1.1
Qualifications: nursing, teaching	0.5	0.8	2.7	-0.2	-1.6	-0.4	-0.2	0.6	1.6	-0.0
Commuting to job workplace: Walk	0.9	1.0	2.1	-1.1	1.1	0.6	-0.2	-1.5	-1.3	-0.4
Eye problems/disorders: Cataract	0.5	0.5	1.6	1.0	1.3	-0.1	0.5	-0.3	-0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	5.4	0.9	1.6	2.3	-0.9	-2.2	0.9	-1.4
Medication for cholesterol	0.2	0.4	1.1	-0.3	-1.1	-0.8	-0.0	-0.4	0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.6	-0.1	-0.3	-0.7	-0.3	1.3	-0.3	0.0
Back pain experienced in last month	2.0	3.0	6.9	2.6	1.9	2.1	0.1	1.8	-1.5	0.7
Mineral and other dietary supplements	2.0	2.7	8.3	-1.3	-1.6	-2.9	-0.6	-0.9	1.9	-1.1
Breast cancer (self-reported)	0.1	0.1	0.4	0.3	-0.3	-0.1	0.1	0.6	0.4	0.2
Asthma (self-reported)	0.8	1.5	2.8	1.5	0.0	-1.4	-1.7	-0.6	1.2	-1.3
Osteoporosis (self-reported)	0.7	0.8	3.6	-0.7	-1.0	-1.9	0.5	0.4	0.4	0.2
Osteoarthritis (self-reported)	0.8	1.0	4.1	0.5	1.1	2.0	-0.2	0.2	-1.1	-0.2
Medication: Aspirin	0.4	0.5	2.0	0.1	1.4	0.9	0.4	0.1	-0.6	0.4
Medication: Gliclazide	0.8	1.0	3.7	-0.5	1.5	1.9	0.3	-0.3	-0.4	0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	2.2	-0.1	-0.1	0.2	-1.0	0.2	-0.4	-1.5
Smoking status: Current	2.3	3.7	7.8	0.6	1.8	1.5	2.8	1.2	-2.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.5	-0.3	0.5	1.4	-0.3	-0.3	-1.6	0.3
Whole body water mass	0.3	1.7	3.5	-0.2	-1.0	-1.4	-1.9	-1.1	0.9	-1.8
Leg predicted mass (right)	0.3	1.7	3.9	0.1	-0.7	-1.2	-1.9	-1.1	1.0	-2.0
Arm fat mass (left)	0.3	1.3	4.0	1.4	0.4	0.5	-2.0	-0.3	-0.1	-1.6
Number of self-reported non-cancer illnesses	0.9	1.6	4.0	2.0	1.8	1.4	0.3	0.3	-1.5	0.1
Average weekly champagne plus white wine intake	0.9	1.3	3.0	0.6	-0.9	-1.6	-0.7	-1.7	1.0	-0.8
Miserableness	1.2	2.1	5.8	0.5	2.4	1.8	0.8	-0.9	-2.0	0.2
Guilty feelings	0.9	1.4	3.1	-0.1	1.3	1.1	1.1	0.9	-1.8	1.3
Wears glasses or contact lenses	0.4	0.4	2.0	1.4	-0.2	-0.1	-0.8	0.3	-0.1	-0.1
Ever taken oral contraceptive pill	1.4	1.6	3.4	-0.9	-1.8	-1.7	1.5	0.8	0.2	1.1
Hearing aid user	1.0	1.2	3.0	1.7	1.4	1.0	0.5	0.2	-0.7	1.2
Mother’s age at death	0.4	0.5	1.4	0.4	0.2	0.6	-1.1	-1.2	0.4	-0.4
Financial situation satisfaction	0.3	0.4	1.3	1.2	0.2	0.1	-0.3	0.8	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	1.5	1.8	7.2	2.7	1.9	0.6	-0.6	0.5	-0.8	0.1
Commuting to job workplace: Public transport	0.7	0.9	3.2	0.5	-0.3	-0.1	-0.1	-1.8	1.5	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.4	1.5	1.1	0.0	-1.3	-1.2	-0.5	-1.5
Medication: Blood pressure	0.5	0.9	1.7	0.6	0.5	-0.7	-1.3	-1.1	1.2	-0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.4	0.9	1.5	2.1	-0.5	1.0	-1.3	0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.1	1.4	-0.1	0.9	0.3	1.8	-1.0	1.0
High cholesterol (Self-reported)	0.6	1.0	1.9	-0.1	0.3	1.2	1.3	1.4	-0.7	1.1
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	-0.6	-0.1	-0.7	0.7	0.4	0.2
Medication: Paracetamol	1.0	1.5	6.3	0.4	1.6	2.5	-0.7	-0.3	-1.0	-0.1
Medication: Lisinopril	0.9	1.1	2.5	-0.4	1.1	1.6	-0.4	-1.4	0.2	-1.4
Medication: Atorvastatin	0.8	1.0	2.4	0.8	1.3	1.5	-0.2	-1.2	0.4	-0.8
Illnesses of father: High blood pressure	0.1	0.1	0.4	0.4	-0.2	-0.6	-0.1	-0.1	0.2	0.3
Alcohol drinker status: Never	0.1	0.1	0.4	0.1	-0.4	-0.6	-0.2	0.3	0.4	0.2
Ever smoked	1.1	1.9	5.0	-0.3	1.8	2.2	0.1	-1.4	-1.7	0.2
Basal metabolic rate	0.4	2.0	4.8	0.1	-1.0	-1.3	-2.2	-1.0	1.0	-2.0
Leg fat percentage (left)	0.4	1.6	4.3	1.9	0.2	0.3	-2.1	-0.2	0.0	-1.7
Arm fat-free mass (left)	0.3	1.4	3.1	0.2	-0.8	-1.1	-1.8	-1.1	0.6	-1.8
Number of operations (self-reported)	1.3	2.0	6.3	1.1	1.9	2.5	-0.2	0.1	-1.6	-0.1
Average weekly beer plus cider intake	1.7	2.5	5.4	-1.5	-0.7	0.9	1.3	2.3	-2.0	1.7
Irritability	2.9	4.9	7.3	-1.5	0.6	2.7	2.6	2.5	-2.3	2.5
Risk taking	1.3	1.9	5.6	-1.1	0.5	0.6	2.4	0.5	-0.9	2.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.3	0.8	0.3	-0.5	-0.1	0.7	0.1
Fractured/broken bones in last 5 years	0.6	0.8	2.9	-0.6	-1.1	-1.7	0.1	0.1	1.0	-0.1
Age started oral contraceptive pill	1.5	1.9	6.7	-0.1	-2.6	-1.4	-1.1	-0.0	1.8	-0.4
Diastolic blood pressure, automated reading	0.5	1.5	4.9	2.2	0.9	-0.4	-1.1	-0.8	0.1	-1.6
Ever depressed for a whole week	0.7	0.9	1.9	1.2	1.4	1.3	-0.1	0.2	-0.9	-0.6
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.2	-0.9	0.1	-0.1	-0.8	0.4	-0.2
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.7	-0.6	-0.8	0.2	-0.1	0.3	0.3
Myopia	1.0	1.5	4.4	-0.4	-1.2	-1.4	-1.1	-0.7	2.1	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.8	-0.3	-0.6	-0.2	0.8	1.7	-0.6	0.9
Cholesterol lowering medication	0.6	0.9	2.8	0.2	0.5	0.9	0.3	1.7	-1.0	1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.6	1.6	0.4	0.9	-0.9	-0.0	-0.1	-0.1
Pain experienced in last month	2.2	3.6	9.6	-2.1	-3.1	-2.1	0.1	-1.5	1.9	-1.0
Supplements: Calcium	1.3	1.4	4.3	0.2	1.7	2.1	1.2	-0.2	-0.9	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.1	-0.5	0.7	0.2	0.5	0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.9	1.2	5.0	-0.4	2.2	1.0	-0.5	-0.7	-1.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.4	0.6	0.5	0.9	0.4	-0.7	0.7
Heart disease (siblings)	0.8	1.0	2.1	1.1	1.1	1.4	-0.6	-1.4	0.0	-0.4
Alcohol drinker status: Previous	0.6	0.7	2.6	1.6	0.8	0.3	-1.0	-0.1	-0.7	-0.1
Pack years of smoking	1.0	1.4	2.8	0.9	-0.1	1.1	1.7	1.2	-1.0	1.5
Impedance of whole body	0.2	0.9	3.1	0.0	-1.7	-0.4	-0.1	1.5	0.6	0.8
Leg fat mass (left)	0.4	1.7	5.0	1.7	-0.1	0.1	-2.2	-0.4	0.3	-1.9
Arm predicted mass (left)	0.3	1.7	4.0	0.3	-0.5	-1.1	-2.0	-1.3	0.9	-2.0