Hub : Genes

CLTB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1984 0.0543 2.9e-06 0.116 NA 0.124 NA 0.129 3.5e-09 NA 1.0e-09 NA 4.8e-10
2 GTEx Skin Not Sun Exposed Suprapubic 0.1260 0.0480 2.2e-03 0.041 NA 0.001 NA 0.020 2.7e-03 NA 2.6e-01 NA 2.8e-02
3 GTEx Skin Sun Exposed Lower leg 0.1820 0.0520 4.8e-06 0.049 NA 0.078 NA 0.061 6.7e-05 NA 4.7e-07 NA 9.3e-06
4 GTEx Whole Blood 0.0640 0.0250 2.0e-03 0.054 NA 0.045 NA 0.057 9.5e-06 NA 5.3e-05 NA 6.1e-06
5 NTR Blood 0.0217 0.0092 2.4e-03 0.018 0.008 0.019 0.010 0.012 1.0e-06 1.1e-03 4.8e-07 2.5e-04 4.7e-05
6 ROSMAP Brain Pre-frontal Cortex 0.0367 0.0157 4.6e-03 0.007 0.016 0.010 0.014 0.008 3.5e-02 3.3e-03 1.7e-02 5.2e-03 3.0e-02
7 YFS Blood 0.1721 0.0280 0.0e+00 0.127 0.177 0.183 0.175 0.170 2.1e-39 1.1e-55 1.7e-57 9.9e-55 2.2e-53

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.8 2.8 6.0 0.0 -1.1 -2.4 -1.8 -2.0 1.0 -2.1
Bipolar Disorder or Schizophrenia 0.9 2.2 8.2 0.0 -2.9 -2.1 -0.6 -1.0 0.8 -1.1
Depressed Affect (Nagel 2018) 3.0 6.2 12.2 1.0 3.5 2.9 2.2 0.8 -3.4 2.1
Depression (Nagel 2018) 2.5 3.8 7.5 0.0 1.5 2.3 2.1 1.4 -2.7 2.3
Intelligence (Savage-Jansen 2018) 0.4 1.3 3.4 0.9 1.3 1.9 0.5 -1.5 -0.7 0.0
Neuroticism (Nagel 2018) 2.4 5.6 9.0 -0.2 2.2 2.5 3.0 1.6 -3.0 2.8
Schizophrenia (2018) 0.6 1.3 7.9 0.0 -2.8 -0.8 0.7 0.4 0.2 0.3
Schizophrenia vs Biploar Disorder 1.0 1.3 2.7 0.0 -1.1 0.6 1.5 1.6 -0.6 1.6
Worry (Nagel 2018) 0.5 1.1 1.8 -1.1 -0.9 0.9 1.3 1.0 -0.7 1.3
Alzheimer’s Disease (in mother) 0.4 0.4 1.9 1.4 -0.0 -0.7 0.4 -0.2 0.7 -0.0
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.4 0.5 0.5 0.6 0.2 0.1 0.0
Alzheimer’s Disease (including proxy) 0.4 0.5 1.6 1.3 -0.1 -0.1 1.0 0.7 0.6 0.4
Crohns Disease (2017) 0.4 1.0 1.7 -0.4 0.7 1.2 1.3 -0.0 -1.1 1.3
Irritable Bowel Disease (IBD) 0.8 1.8 3.9 -0.3 1.1 1.8 1.4 0.5 -2.0 1.5
Ulcerative Colitis (UC) 0.4 0.8 2.3 -0.1 0.0 0.8 0.9 1.0 -1.5 1.0
Major Depression (MDD) 0.9 1.1 3.4 0.0 1.8 0.0 -1.1 0.0 0.0 -1.7
Reaction Time 1.4 2.7 5.7 -1.3 -1.4 -0.7 -1.2 -2.2 1.7 -2.4
Verbal and Numeric Reasoning (VNR) 1.0 2.4 6.9 0.3 2.1 2.6 0.7 -1.9 -1.1 0.3
Breast Cancer 0.4 1.1 4.6 -2.1 -1.1 0.2 -0.8 -0.6 0.2 -0.8
Ovarian Cancer 0.3 0.4 1.3 0.6 1.1 0.7 0.2 0.3 -0.1 0.9
Prostate Cancer 0.2 0.3 1.5 -0.6 -1.2 0.2 0.3 0.2 -0.1 0.4
Age at First Birth 3.3 4.7 9.8 -0.1 -1.2 -1.3 -2.2 -2.5 3.1 -3.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 2.5 0.0 -0.2 -0.8 -0.8 1.6 0.2 0.2
Coronary Artery Disease (CAD) 3.4 4.0 7.6 0.0 -0.7 1.4 2.4 2.7 -2.2 2.8
Crohns Disease (2012) 0.4 0.7 1.4 0.0 -0.2 0.5 0.8 1.2 -1.1 1.1
Mean Putamen Volume 0.1 0.1 0.2 0.0 -0.5 0.4 -0.0 0.0 0.3 0.0
Fasting Glucose 0.5 0.6 2.3 1.2 1.5 0.7 -0.1 -0.6 0.0 -0.2
HbA1C 0.3 0.4 1.0 0.0 -1.0 -0.4 -1.0 0.2 0.7 0.0
HDL Cholesterol 0.3 0.5 1.3 0.0 -0.2 -1.0 0.0 -1.1 0.8 -0.7
LDL Cholesterol 1.1 1.8 5.0 0.0 -1.0 -2.2 -1.9 -0.7 1.0 -1.2
Lupus 0.4 0.6 1.1 0.9 0.6 0.7 -0.8 -0.2 0.8 -1.1
Neuroticism (2016) 0.5 0.7 1.4 0.5 1.2 0.8 0.7 -1.1 -0.8 0.6
Primary Biliary Cirrhosis 0.4 0.6 1.8 0.0 -0.7 0.4 0.8 1.4 0.0 1.0
Rheumatoid Arthritis 0.2 0.2 0.7 0.0 -0.1 -0.8 -0.2 -0.8 0.3 -0.4
Schizophrenia (2014) 1.2 2.6 11.2 0.0 -3.4 -2.4 0.3 0.2 0.7 -0.5
Triglycerides 0.4 0.7 2.0 0.0 0.4 1.4 0.5 -0.7 -1.3 0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.9 0.0 -1.3 -1.4 0.1 0.8 0.1 -0.1
Ulcerative Colitis 1.0 1.5 3.2 0.0 1.4 1.2 1.4 0.3 -1.8 1.3
Blood Eosinophil Count 0.1 0.9 1.8 1.4 0.2 -1.2 0.9 -1.1 0.9 0.4
Blood Platelet Count 0.2 2.1 4.8 1.5 -1.0 -2.2 -1.0 -1.5 1.8 -0.5
Blood Red Count 0.5 5.3 12.0 2.6 -0.6 -0.6 -2.5 -2.7 2.1 -3.5
Blood White Count 0.1 0.8 2.7 1.6 1.3 0.6 -0.2 -0.7 -0.6 -0.4
Heel T-Score 0.2 1.9 4.5 0.1 -0.3 -0.7 -2.1 -1.6 1.8 -1.5
BMI 0.4 2.5 3.8 1.8 1.9 1.9 -1.9 -0.6 -0.9 -1.5
Height 1.0 18.7 64.2 -1.4 -8.0 -5.6 -2.8 0.1 4.9 -1.3
Waist Hip Ratio (WHR) 0.2 0.7 1.2 1.1 -1.1 -0.3 0.5 1.0 -0.4 1.0
Systolic Blood Pressure 0.4 2.0 5.7 1.6 0.0 -0.7 -2.4 -0.6 1.1 -1.9
Smoking Status 0.8 2.0 4.1 1.2 2.0 2.0 0.6 -0.1 -2.0 0.1
Allergy or Eczema 0.2 0.4 2.0 -0.1 1.4 0.4 0.6 -0.3 -0.7 -0.0
Cardiovascular Disease 0.2 0.8 1.6 0.8 0.8 0.4 -1.0 -0.8 1.0 -1.3
Hypothyroidism (self reported) 0.4 0.9 1.8 1.1 0.4 1.1 0.5 1.3 -0.9 1.0
Respiratory disease 0.3 0.8 3.4 1.8 0.3 -0.4 -0.2 -0.3 1.2 -0.3
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.5 0.9 1.2 0.8 -1.0 -1.1 0.3 -0.8
Lung FEV1/FVC ratio 0.6 3.0 7.8 0.2 2.8 2.8 -0.5 -0.5 -2.3 0.1
Lung FVC 0.2 0.8 2.1 -0.2 0.4 1.4 0.8 -1.1 -1.3 0.4
Neuroticism 2.6 6.3 11.1 -1.3 1.6 2.7 3.1 1.7 -3.3 3.0
Chronotype (morning person) 0.2 0.4 1.3 -0.7 0.4 -0.2 -1.0 -0.2 1.1 -0.2
Hair Pigment 0.0 1.0 2.9 -1.2 -1.6 -0.3 0.1 1.7 -0.1 -0.3
Tanning 0.1 0.9 2.7 0.6 1.6 1.3 -0.8 0.7 0.0 0.3
Hand grip strength (left) 0.4 1.0 4.9 -2.2 -0.3 -0.3 -0.5 -0.8 -0.1 -0.8
Number of treatments/medications taken 1.9 3.5 8.4 2.2 2.0 2.9 0.8 0.8 -2.1 1.2
Average weekly spirits intake 0.9 1.2 4.0 1.2 2.0 1.0 0.0 0.3 -1.2 0.3
Sensitivity / hurt feelings 0.6 1.0 2.0 -0.5 0.9 0.7 0.4 1.3 -1.4 1.3
Frequency of depressed mood in last 2 weeks 1.8 2.5 4.8 -1.0 0.7 1.8 2.0 0.8 -1.9 2.2
Hearing difficulty/problems: Yes 1.3 2.0 5.4 0.6 0.6 0.9 2.3 1.6 -1.0 1.8
Relative age of first facial hair 0.3 0.7 1.4 1.2 -0.8 -0.2 -0.8 -0.9 1.1 -0.6
Other serious medical condition/disability diagnosed by doctor 2.1 2.8 6.8 0.8 2.2 2.6 1.1 0.9 -2.2 0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 0.2 -1.1 0.7 0.8 0.0 0.2 0.5
Ever had hysterectomy (womb removed) 1.9 2.1 5.3 0.4 0.7 0.6 1.2 2.3 -2.1 1.7
Systolic blood pressure, automated reading 0.4 1.1 4.2 2.1 0.7 -0.3 -1.0 -0.8 0.4 -1.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.9 1.7 -0.6 -0.4 -1.5 -1.0 0.9 -0.9
Angina 0.3 0.4 0.7 0.6 0.9 0.6 0.6 -0.6 -0.8 0.2
Medication for hormone replacement therapy 0.7 0.8 1.3 0.6 0.9 1.1 1.0 0.6 -1.0 0.9
Vitamin and mineral supplements 0.2 0.3 1.1 0.7 0.2 -0.4 -0.3 1.1 -0.3 0.1
Supplements: Zinc 0.4 0.4 1.1 0.4 1.0 -0.3 -0.5 -0.9 0.6 -0.3
Medication: Co-codamol 0.7 0.8 1.5 0.7 1.1 1.2 1.2 -0.5 -0.3 0.2
Medication: Metformin 0.4 0.5 2.1 0.5 -0.6 -0.0 0.5 -0.8 1.4 -0.0
Diabetes (father) 0.6 0.8 2.0 -1.2 -0.9 -0.8 -0.0 -0.8 1.4 -0.1
Diabetes (mother) 0.4 0.5 1.5 0.1 1.2 -0.6 -0.5 -1.1 0.0 -0.5
Severe depression (siblings) 1.1 1.2 3.5 0.1 1.7 1.9 0.1 -0.7 -0.2 -1.2
Pack years adult smoking proportion 0.5 0.8 1.7 0.9 -0.1 0.7 1.3 0.8 -0.7 1.1
Impedance of leg (right) 0.1 0.7 2.3 -0.2 -1.5 -0.5 -0.3 1.1 0.5 0.6
Leg fat-free mass (left) 0.2 1.3 3.5 -0.0 -0.5 -1.0 -1.9 -1.0 0.7 -1.7
Trunk fat percentage 0.5 1.9 6.5 1.9 -0.7 0.2 -2.5 0.3 0.4 -1.5
Hand grip strength (right) 0.2 0.6 2.2 -1.5 -0.1 0.2 -0.6 -0.7 -0.0 -1.0
Townsend deprivation index at recruitment 1.0 1.4 2.5 1.2 -1.2 -1.6 1.4 0.5 0.2 1.3
Current tobacco smoking 2.6 4.3 8.9 0.4 2.2 1.9 2.7 1.3 -3.0 1.9
Average weekly fortified wine intake 0.4 0.5 1.8 1.3 0.6 -0.3 -0.4 0.6 -0.6 0.4
Maternal smoking around birth 0.3 0.4 0.8 0.3 -0.8 -0.3 0.4 0.9 0.8 0.4
Fed-up feelings 1.9 3.5 7.9 0.8 2.2 2.0 1.8 1.4 -2.8 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.8 9.8 0.4 0.9 1.7 2.2 1.9 -3.1 2.2
Relative age voice broke 0.2 0.2 0.8 0.1 -0.1 -0.4 -0.8 -0.9 -0.2 -0.3
Taking other prescription medications 1.9 3.0 7.8 0.4 1.4 2.8 1.8 0.8 -2.0 1.8
Age when periods started (menarche) 0.1 0.2 0.7 -0.9 0.5 0.5 -0.2 -0.2 -0.4 0.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.4 1.0 1.5 0.9 -0.8 0.5 -0.8 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.0 -1.0 -0.3 -0.2 -0.6 0.8 -0.8 -0.4
Tinnitus: Yes, but not now, but have in the past 1.8 2.0 8.7 0.0 -1.3 -0.2 0.1 -3.0 1.4 -1.2
Qualifications: CSEs or equivalent 1.3 1.7 2.8 1.4 0.0 -0.9 -1.2 -1.6 1.7 -1.6
Serious illness, injury or assault to yourself 0.2 0.2 0.7 0.8 -0.0 0.3 -0.5 -0.2 -0.2 -0.6
High blood pressure 0.2 0.7 2.5 0.4 0.5 0.1 -0.5 -1.6 1.0 -0.7
Hayfever, allergic rhinitis or eczema 0.6 1.4 2.3 0.1 1.4 1.4 1.2 1.0 -1.5 0.7
Multivitamins +/- minerals 0.3 0.3 0.7 -0.7 -0.5 0.2 -0.1 -0.8 0.7 -0.6
Stomach or abdominal pain in last month 0.3 0.3 1.3 0.6 1.1 0.4 0.1 -0.6 0.0 0.0
Supplements: Glucosamine 2.2 2.8 8.6 1.1 2.7 2.9 0.1 -0.2 -1.4 0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.7 1.6 0.7 0.1 -0.8 -0.0 0.1 -0.6
Medication: Atenolol 0.1 0.1 0.4 -0.3 0.0 0.4 0.4 0.6 -0.1 0.5
Medication: Levothyroxine sodium 0.8 1.4 3.0 1.7 1.1 1.2 0.6 1.2 -0.8 1.3
Sitting height 0.3 2.1 4.8 -1.3 -2.2 -1.9 -1.4 -0.3 1.1 -0.8
Chronic bronchitis/emphysema (father) 3.2 3.8 8.8 -0.5 -0.6 0.1 2.8 2.5 -1.6 3.0
High blood pressure (mother) 1.1 1.5 2.8 1.1 0.9 0.9 -1.1 -1.3 1.7 -1.5
Body mass index (BMI) 0.4 1.6 2.8 1.6 1.2 0.7 -1.7 -0.9 -0.4 -1.7
Impedance of leg (left) 0.2 0.9 4.1 0.2 -2.0 -0.6 -0.2 1.0 0.7 0.3
Leg predicted mass (left) 0.3 1.5 3.9 0.1 -0.4 -1.0 -2.0 -1.1 0.8 -1.9
Trunk fat mass 0.5 2.2 7.7 1.7 -0.8 -0.2 -2.8 -0.1 0.7 -1.9
Waist circumference 0.6 2.0 5.4 2.3 -0.7 -0.6 -1.9 -0.6 0.8 -1.8
Number of incorrect matches in round 0.2 0.4 1.1 -0.3 -0.6 -0.9 -0.6 -0.1 1.0 -0.4
Past tobacco smoking 0.7 1.3 4.6 -0.5 -1.2 -2.1 -0.0 0.8 1.4 -0.2
Alcohol usually taken with meals 2.8 4.5 9.8 1.7 0.3 -0.7 -3.1 -2.3 2.4 -2.8
Nervous feelings 0.6 1.1 4.6 -2.1 -1.5 0.7 0.5 0.1 0.6 0.1
Frequency of tenseness / restlessness in last 2 weeks 3.2 4.9 10.7 -0.6 0.3 2.5 3.3 1.4 -2.8 2.7
Hearing difficulty/problems with background noise 1.2 1.9 4.1 -0.7 0.7 0.3 2.0 2.0 -1.2 1.7
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 1.1 -0.0 0.3 0.2 0.6 0.5 0.6
Had menopause 1.3 1.6 4.2 0.0 -1.6 -0.8 -0.3 -1.8 2.1 -0.9
Had other major operations 1.3 1.6 5.1 -0.1 1.3 2.3 0.9 1.2 -1.4 0.7
Forced vital capacity (FVC) 0.2 0.8 1.7 -1.0 -1.3 -0.4 -0.9 -0.8 0.5 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 -1.1 -0.5 -0.4 -0.9 0.6 -0.8 -0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.9 1.7 0.8 1.0 0.3 -0.7 0.2 -1.0
Qualifications: None of the above 2.2 4.7 11.5 -0.7 -0.6 0.5 1.9 3.4 -3.0 2.7
Financial difficulties in last 2 years 0.5 0.7 2.2 1.0 -0.5 -0.1 -0.2 -0.4 1.3 -1.5
Mouth/teeth dental problems 0.8 1.3 3.4 -1.8 -1.8 -1.3 0.4 0.5 0.3 0.5
Heart attack 0.9 1.1 5.1 -0.4 2.3 0.9 -0.4 -0.6 -1.0 -0.1
Allergy 0.1 0.3 2.0 -0.5 -1.4 -0.1 0.0 -0.3 0.0 0.2
Pain all over the body in last month 0.6 0.7 1.5 -0.8 0.4 0.5 0.6 0.8 -1.1 1.2
Diabetes (self-reported) 0.4 0.7 2.8 1.7 0.9 0.8 0.1 -0.3 0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 0.4 -0.7 -0.3 0.8 0.8 -0.6 0.6
Medication: Ramipril 1.7 2.1 7.4 0.2 -0.7 -1.2 -0.6 -2.7 1.9 -1.4
Medication: Simvastatin 0.1 0.2 0.4 -0.2 -0.0 0.6 0.5 0.5 -0.3 0.4
Fluid intelligence score 0.6 1.3 4.6 0.2 0.8 0.4 -0.6 -2.1 1.0 -1.5
Illnesses of siblings 1.4 2.0 4.2 -2.1 -0.2 -0.3 1.8 1.9 -1.1 1.3
Neuroticism score 1.6 3.3 6.9 -0.6 0.8 1.8 2.6 1.3 -2.4 2.2
Weight 0.5 2.3 7.1 1.0 -1.0 -1.0 -2.7 -0.6 0.9 -2.2
Impedance of arm (right) 0.2 0.9 2.5 -0.6 -1.6 -0.7 -0.2 1.3 0.6 0.7
Arm fat percentage (right) 0.4 1.4 4.6 1.4 0.4 0.3 -2.2 -0.5 0.1 -1.8
Trunk fat-free mass 0.3 2.0 3.1 -0.3 -1.4 -1.7 -1.8 -1.2 1.3 -1.7
Hip circumference 0.9 3.7 9.2 1.3 -1.5 -1.2 -3.0 -1.1 1.7 -2.7
Time employed in main current job 0.6 0.6 1.5 1.2 -0.5 -1.2 -0.7 0.8 -0.2 -0.1
Alcohol intake versus 10 years previously 0.7 1.0 3.7 -1.3 -1.9 -0.6 0.7 -0.1 0.9 0.5
Father’s age at death 1.3 1.7 3.7 0.5 0.9 -0.5 -1.7 -1.7 1.2 -1.9
Worrier / anxious feelings 0.9 1.6 3.3 -1.8 0.4 0.1 1.5 1.1 -1.5 1.4
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.0 7.0 0.2 1.5 2.6 2.2 1.3 -2.5 2.5
Falls in the last year 0.2 0.3 0.9 0.5 -0.8 0.1 1.0 -0.2 0.3 0.6
Hair/balding pattern: Pattern 3 0.5 0.7 1.8 1.3 0.2 -0.6 -0.6 1.3 -0.8 0.3
Number of live births 1.5 2.2 5.4 -0.8 -1.3 -2.3 -1.2 -0.7 1.8 -1.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.8 -0.9 -1.1 -0.4 -1.2 -1.1 0.9 -1.3
Pulse rate 1.8 3.1 6.9 1.3 2.6 2.0 1.3 -1.6 -2.2 0.4
Happiness 0.6 0.7 1.7 -0.7 -0.8 -1.3 0.8 0.9 -0.5 0.7
Noisy workplace 3.1 3.8 8.4 1.0 0.6 0.6 2.4 2.3 -2.9 2.3
Qualifications: A levels/AS levels or equivalent 2.0 4.3 9.9 -1.5 -0.7 -0.7 -2.0 -3.1 2.9 -2.2
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 4.3 1.2 -0.1 -1.1 -2.1 -0.9 1.3 -1.5
Mouth/teeth dental problems: Dentures 1.0 1.6 3.2 1.7 1.8 1.1 0.5 0.5 -1.7 0.7
Asthma 0.7 1.4 2.7 1.3 -0.1 -1.6 -1.6 -0.4 1.2 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.6 0.8 0.5 -0.4 -0.0 0.5 -0.8
Medication: Cholesterol lowering 0.2 0.3 1.0 -0.4 0.2 1.0 0.7 -0.6 0.5 -0.0
Depression (self-reported) 1.2 1.4 4.8 -2.2 0.9 0.9 1.1 0.6 -1.1 0.7
Medication: Lansoprazole 1.2 1.3 3.5 -0.2 -1.9 -1.6 -1.0 0.2 1.3 -0.7
Prospective memory result 0.5 0.6 2.6 -1.6 0.6 -0.5 0.2 -0.5 -0.5 0.5
Lung cancer (father) 0.4 0.5 1.2 0.8 0.6 0.3 -0.7 0.1 0.9 -1.1
Illnesses of mother 1.8 2.2 3.7 -1.3 -0.5 -1.0 1.3 1.8 -1.9 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.9 -0.3 -0.1 0.1 -0.4 -0.5 -0.0 -0.9
Pulse wave Arterial Stiffness index 0.9 1.1 5.8 2.4 0.1 0.4 -0.9 -0.6 -0.5 -0.1
Impedance of arm (left) 0.2 0.8 2.3 -0.4 -1.3 -0.4 0.0 1.5 0.4 0.9
Arm fat mass (right) 0.4 1.5 4.7 1.4 0.1 0.2 -2.2 -0.7 0.2 -1.9
Trunk predicted mass 0.3 1.9 3.0 -0.4 -1.2 -1.7 -1.7 -1.2 1.2 -1.7
Standing height 0.6 6.3 21.1 -1.1 -4.6 -3.3 -1.9 1.0 2.4 -0.6
Length of working week for main job 1.2 1.3 3.0 0.3 -1.1 -1.3 -1.1 -0.6 1.7 -1.1
Exposure to tobacco smoke at home 1.1 1.2 3.5 0.9 1.3 0.8 0.4 1.2 -1.9 0.4
Breastfed as a baby 0.2 0.3 0.7 0.6 0.5 0.6 0.2 0.3 -0.8 -0.0
Tense / ‘highly strung’ 1.7 2.9 8.3 -0.7 -0.7 0.7 2.5 1.8 -0.9 2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.1 -1.2 1.6 2.0 0.8 -0.9 -1.1 -0.2
Hair/balding pattern: Pattern 4 0.1 0.4 0.8 -0.8 -0.1 0.2 0.6 -0.9 -0.0 -0.8
Birth weight of first child 0.2 0.3 1.0 0.2 1.0 0.2 -0.1 0.5 -0.6 -0.5
Peak expiratory flow (PEF) 0.4 1.0 1.6 -1.0 -1.1 -0.0 -1.3 -0.7 1.2 -1.3
Pulse wave reflection index 0.3 0.3 1.5 0.3 -0.3 0.0 -0.4 1.2 -0.2 0.6
Ever highly irritable/argumentative for 2 days 0.8 1.0 1.8 1.2 1.1 1.1 -0.4 -0.1 -1.0 -1.4
Loud music exposure frequency 0.8 0.8 1.3 -1.1 0.1 -0.0 1.1 1.1 -0.9 1.2
Qualifications: O levels/GCSEs or equivalent 2.1 3.3 7.3 -0.6 0.4 -1.0 -1.5 -2.7 2.5 -2.4
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.5 0.9 -0.6 -0.3 -1.0 -1.1 1.9 -1.3
Blood clot in the leg (DVT) 0.1 0.2 0.4 -0.2 0.5 0.5 0.6 -0.1 -0.2 0.4
Medication: Paracetamol 0.7 1.2 5.0 0.7 1.2 2.2 -1.0 -0.1 -0.4 -0.3
Headache pain in last month 0.7 1.2 3.6 1.5 1.9 0.8 -0.3 -0.3 -1.2 -0.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 5.2 -0.2 -0.9 -2.3 -1.5 0.4 1.0 -0.7
Glaucoma (self-reported) 0.9 1.1 2.7 1.0 1.1 -0.5 -1.6 -0.5 -0.6 -1.3
Gout (self-reported) 4.3 5.9 12.7 -3.1 1.2 1.0 2.6 1.8 -3.6 2.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 0.7 0.5 0.5 0.8 0.9 -0.5 1.1
Medication: Amlodipine 0.2 0.2 0.8 -0.3 -0.5 -0.2 -0.0 0.3 0.9 0.7
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.5 1.3 1.9 1.1 -0.6 0.1 -1.6 -0.3
Birth weight 0.6 1.4 4.2 -1.8 -2.0 -1.2 0.6 0.4 0.4 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.8 0.3 0.2 0.9 0.6 -0.8 0.7 -0.1
High blood pressure (siblings) 0.5 0.7 2.0 1.4 -0.2 -0.0 -1.4 -0.7 0.2 -0.5
Forced vital capacity (FVC), Best measure 0.0 0.2 0.5 -0.5 -0.7 -0.1 -0.2 -0.2 -0.2 -0.6
Body fat percentage 0.5 2.0 6.8 2.0 -0.2 0.3 -2.6 -0.0 0.3 -1.8
Leg fat percentage (right) 0.4 1.5 5.0 1.6 0.4 0.4 -2.2 -0.3 0.1 -1.6
Arm fat-free mass (right) 0.4 2.3 4.8 0.4 -0.9 -1.4 -2.2 -1.4 1.2 -2.2
Exposure to tobacco smoke outside home 0.1 0.1 0.4 -0.4 -0.0 -0.6 0.1 0.0 -0.0 0.5
Comparative body size at age 10 0.6 1.7 2.9 -1.7 1.5 0.7 0.8 -1.6 -1.6 -0.4
Number of full brothers 0.3 0.4 1.1 0.8 0.2 1.0 0.8 0.3 -0.7 0.0
Worry too long after embarrassment 1.6 2.6 5.5 -0.5 1.5 1.4 2.4 1.1 -1.9 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.4 -1.6 -0.8 0.1 1.1 0.4 -0.2 1.1
Wheeze or whistling in the chest in last year 0.9 1.7 4.6 2.1 0.5 0.1 0.7 1.3 -1.7 1.2
Number of children fathered 1.5 1.7 4.3 1.1 -0.5 -0.1 -1.8 -0.9 1.4 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.3 -0.4 -0.2 -0.6 1.1 0.1 -0.4 1.1
Age at first live birth 1.1 2.0 7.8 -1.5 -0.4 0.7 -0.3 -2.8 1.6 -0.9
Pulse wave peak to peak time 1.0 1.2 5.9 -2.4 -0.5 -0.9 0.6 0.7 0.7 -0.1
Health satisfaction 0.4 0.5 1.2 1.0 -0.8 -0.2 -1.1 0.6 0.3 -0.5
Shortness of breath walking on level ground 1.7 2.0 4.8 2.2 1.5 1.7 -0.0 1.3 -1.6 0.5
Qualifications: College or University degree 0.6 2.0 6.3 -2.5 -0.5 -1.0 0.5 -2.1 1.4 0.0
Eye problems/disorders: None of the above 1.7 1.9 4.5 -1.6 -2.0 -0.4 0.5 0.9 2.1 1.1
Mouth/teeth dental problems: Loose teeth 0.7 0.9 3.1 0.6 -0.9 -1.8 0.5 0.9 0.9 0.0
Emphysema/chronic bronchitis 0.6 0.7 2.4 1.1 -0.1 -0.9 -0.1 -0.2 1.6 -0.8
Medication for pain relief, constipation, heartburn 0.3 0.6 1.2 -1.0 -0.7 -0.8 1.1 -0.2 -0.4 0.5
Neck or shoulder pain in last month 1.2 1.7 3.0 1.7 1.5 1.3 0.0 1.4 -1.7 0.4
Medication: Blood pressure 0.1 0.2 0.7 -0.3 0.2 0.7 0.9 -0.3 -0.3 0.1
Angina (self-reported) 0.4 0.5 1.0 0.8 1.0 0.6 0.6 -0.6 -0.8 0.2
Migraine (self-reported) 2.3 2.8 8.2 1.3 2.9 2.7 -0.8 -1.0 -0.5 -0.7
Medication: Ibuprofen 0.1 0.1 0.3 0.4 0.6 0.2 -0.1 0.4 -0.1 -0.4
Medication: Allopurinol 5.6 7.4 14.1 -2.8 1.4 1.4 3.3 2.3 -3.8 3.1
Medication: Omeprazole 0.6 0.7 2.9 1.7 0.6 0.9 -0.7 -0.2 -0.2 -0.0
Medication: Seretide 50 evohaler 0.7 0.8 2.2 1.3 -0.8 -0.5 -0.8 -0.5 1.5 -0.5
Mean time to correctly identify matches 0.5 1.0 3.5 -0.9 -0.7 0.3 -0.4 -1.9 0.9 -1.2
Heart disease (mother) 0.6 0.7 1.4 1.0 0.4 0.7 -1.1 -1.2 0.3 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.6 -0.7 0.6 0.0 -0.6 -0.4 -0.2 -0.3
Whole body fat mass 0.5 2.0 6.4 1.8 -0.3 0.1 -2.5 -0.4 0.5 -2.0
Leg fat mass (right) 0.5 1.8 5.6 1.7 0.0 0.2 -2.4 -0.5 0.4 -2.0
Arm predicted mass (right) 0.5 2.3 4.6 0.0 -1.1 -1.5 -2.1 -1.4 1.4 -2.1
Pulse rate, automated reading 1.4 4.4 9.1 1.8 2.0 1.9 3.0 0.1 -3.0 1.5
Alcohol intake frequency. 0.3 0.6 1.3 1.1 0.4 0.8 0.2 0.8 -0.7 1.0
Comparative height size at age 10 0.5 2.6 7.5 -0.5 -2.7 -2.7 -0.8 1.3 0.9 0.0
Number of full sisters 0.6 0.8 3.4 -0.1 0.3 -0.6 0.4 1.8 -1.0 0.6
Suffer from ‘nerves’ 0.4 0.7 2.6 0.1 -0.5 1.6 0.5 0.3 -1.1 0.5
Overall health rating 1.4 2.9 6.7 1.3 1.7 2.3 1.1 1.2 -2.6 0.9
Chest pain or discomfort 0.7 1.0 3.4 1.8 0.6 0.9 0.3 -0.6 -1.4 -0.0
Had major operations 0.5 0.6 2.0 0.4 0.6 1.4 0.7 -0.3 -0.9 -0.0
Age at last live birth 0.4 0.6 1.9 -1.4 -0.7 -0.5 0.6 -1.0 0.6 -0.1
Family relationship satisfaction 0.6 0.8 3.7 -0.0 -1.0 -1.9 0.3 0.1 0.7 0.3
Leg pain on walking 0.8 1.0 4.4 -0.5 0.7 0.8 0.2 1.0 -2.1 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 0.4 0.7 0.5 -0.9 0.9 0.3 -0.5
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.6 1.3 1.0 1.6 -1.9 0.0 0.2 -1.7
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 0.3 -0.0 -0.1 0.8 0.5 0.2 0.8
Medication: Aspirin 0.6 0.8 2.8 -0.1 1.7 1.2 0.2 -0.2 -1.0 0.4
Supplements: Vitamin C 0.3 0.3 1.0 -0.7 0.5 -0.2 -0.1 -1.0 0.5 -0.5
Knee pain experienced in last month 0.5 0.8 2.2 1.1 -0.2 0.2 -1.5 -0.6 0.5 -1.3
Hypertension (Self-reported) 0.2 0.7 2.1 0.8 0.9 -0.1 -0.3 -1.5 0.7 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 5.1 1.3 -2.0 -2.2 -0.4 0.5 1.6 -0.3
Illnesses of father: Heart disease 1.1 1.5 5.7 1.2 2.4 1.0 -0.3 -1.6 0.1 -0.2
Illnesses of siblings: Diabetes 1.3 1.6 4.7 0.9 0.9 1.0 -1.4 -2.2 0.9 -1.2
Smoking status: Previous 0.5 0.8 1.5 1.2 0.7 1.2 -0.9 -1.1 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.4 -2.1 -0.8 -0.6 -0.8 0.5 0.6 -0.3
Whole body fat-free mass 0.3 1.9 3.9 -0.1 -1.0 -1.5 -2.0 -1.1 1.1 -1.9
Leg fat-free mass (right) 0.3 1.6 4.1 0.2 -0.6 -1.1 -1.9 -1.1 0.9 -2.0
Arm fat percentage (left) 0.4 1.7 4.8 1.6 0.6 0.7 -2.2 -0.5 0.1 -1.8
Average weekly red wine intake 0.4 0.7 1.6 0.1 0.3 -0.3 -1.2 -1.3 0.7 -1.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.4 -1.2 -0.6 -0.3 0.3 -0.9 0.8 -0.0
Mood swings 1.5 2.7 6.8 0.2 1.9 2.0 1.5 1.0 -2.6 1.1
Loneliness, isolation 3.8 5.2 11.8 -0.0 -0.7 1.5 3.2 2.6 -2.2 3.4
Long-standing illness, disability or infirmity 1.1 1.6 5.0 2.2 1.0 1.6 0.4 0.9 -1.2 0.7
Ever had bowel cancer screening 2.1 2.5 7.2 2.7 2.2 2.2 0.1 -0.6 -0.2 0.3
Diabetes diagnosed by doctor 0.3 0.5 1.1 1.1 0.9 0.9 0.5 0.1 -0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.0 0.1 -0.3 -0.5 0.1 -1.2 1.4 -0.9
Friendships satisfaction 0.9 1.2 2.6 -0.5 -1.2 -0.7 1.3 1.6 -0.7 1.1
Qualifications: nursing, teaching 0.5 0.8 2.7 -0.2 -1.6 -0.4 -0.2 0.6 1.6 -0.0
Commuting to job workplace: Walk 0.9 1.0 2.1 -1.1 1.1 0.6 -0.2 -1.5 -1.3 -0.4
Eye problems/disorders: Cataract 0.5 0.5 1.6 1.0 1.3 -0.1 0.5 -0.3 -0.8 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 5.4 0.9 1.6 2.3 -0.9 -2.2 0.9 -1.4
Medication for cholesterol 0.2 0.4 1.1 -0.3 -1.1 -0.8 -0.0 -0.4 0.2 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.6 -0.1 -0.3 -0.7 -0.3 1.3 -0.3 0.0
Back pain experienced in last month 2.0 3.0 6.9 2.6 1.9 2.1 0.1 1.8 -1.5 0.7
Mineral and other dietary supplements 2.0 2.7 8.3 -1.3 -1.6 -2.9 -0.6 -0.9 1.9 -1.1
Breast cancer (self-reported) 0.1 0.1 0.4 0.3 -0.3 -0.1 0.1 0.6 0.4 0.2
Asthma (self-reported) 0.8 1.5 2.8 1.5 0.0 -1.4 -1.7 -0.6 1.2 -1.3
Osteoporosis (self-reported) 0.7 0.8 3.6 -0.7 -1.0 -1.9 0.5 0.4 0.4 0.2
Osteoarthritis (self-reported) 0.8 1.0 4.1 0.5 1.1 2.0 -0.2 0.2 -1.1 -0.2
Medication: Aspirin 0.4 0.5 2.0 0.1 1.4 0.9 0.4 0.1 -0.6 0.4
Medication: Gliclazide 0.8 1.0 3.7 -0.5 1.5 1.9 0.3 -0.3 -0.4 0.5
Illnesses of father: None of the above (group 1) 0.4 0.5 2.2 -0.1 -0.1 0.2 -1.0 0.2 -0.4 -1.5
Smoking status: Current 2.3 3.7 7.8 0.6 1.8 1.5 2.8 1.2 -2.8 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.5 -0.3 0.5 1.4 -0.3 -0.3 -1.6 0.3
Whole body water mass 0.3 1.7 3.5 -0.2 -1.0 -1.4 -1.9 -1.1 0.9 -1.8
Leg predicted mass (right) 0.3 1.7 3.9 0.1 -0.7 -1.2 -1.9 -1.1 1.0 -2.0
Arm fat mass (left) 0.3 1.3 4.0 1.4 0.4 0.5 -2.0 -0.3 -0.1 -1.6
Number of self-reported non-cancer illnesses 0.9 1.6 4.0 2.0 1.8 1.4 0.3 0.3 -1.5 0.1
Average weekly champagne plus white wine intake 0.9 1.3 3.0 0.6 -0.9 -1.6 -0.7 -1.7 1.0 -0.8
Miserableness 1.2 2.1 5.8 0.5 2.4 1.8 0.8 -0.9 -2.0 0.2
Guilty feelings 0.9 1.4 3.1 -0.1 1.3 1.1 1.1 0.9 -1.8 1.3
Wears glasses or contact lenses 0.4 0.4 2.0 1.4 -0.2 -0.1 -0.8 0.3 -0.1 -0.1
Ever taken oral contraceptive pill 1.4 1.6 3.4 -0.9 -1.8 -1.7 1.5 0.8 0.2 1.1
Hearing aid user 1.0 1.2 3.0 1.7 1.4 1.0 0.5 0.2 -0.7 1.2
Mother’s age at death 0.4 0.5 1.4 0.4 0.2 0.6 -1.1 -1.2 0.4 -0.4
Financial situation satisfaction 0.3 0.4 1.3 1.2 0.2 0.1 -0.3 0.8 -0.6 -0.3
Tinnitus: Yes, now most or all of the time 1.5 1.8 7.2 2.7 1.9 0.6 -0.6 0.5 -0.8 0.1
Commuting to job workplace: Public transport 0.7 0.9 3.2 0.5 -0.3 -0.1 -0.1 -1.8 1.5 -0.5
Eye problems/disorders: Glaucoma 1.1 1.3 2.4 1.5 1.1 0.0 -1.3 -1.2 -0.5 -1.5
Medication: Blood pressure 0.5 0.9 1.7 0.6 0.5 -0.7 -1.3 -1.1 1.2 -0.8
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.4 0.9 1.5 2.1 -0.5 1.0 -1.3 0.2
Supplements: Fish oil (including cod liver oil) 0.9 1.1 3.1 1.4 -0.1 0.9 0.3 1.8 -1.0 1.0
High cholesterol (Self-reported) 0.6 1.0 1.9 -0.1 0.3 1.2 1.3 1.4 -0.7 1.1
Medication: Bendroflumethiazide 0.2 0.3 0.5 0.7 -0.6 -0.1 -0.7 0.7 0.4 0.2
Medication: Paracetamol 1.0 1.5 6.3 0.4 1.6 2.5 -0.7 -0.3 -1.0 -0.1
Medication: Lisinopril 0.9 1.1 2.5 -0.4 1.1 1.6 -0.4 -1.4 0.2 -1.4
Medication: Atorvastatin 0.8 1.0 2.4 0.8 1.3 1.5 -0.2 -1.2 0.4 -0.8
Illnesses of father: High blood pressure 0.1 0.1 0.4 0.4 -0.2 -0.6 -0.1 -0.1 0.2 0.3
Alcohol drinker status: Never 0.1 0.1 0.4 0.1 -0.4 -0.6 -0.2 0.3 0.4 0.2
Ever smoked 1.1 1.9 5.0 -0.3 1.8 2.2 0.1 -1.4 -1.7 0.2
Basal metabolic rate 0.4 2.0 4.8 0.1 -1.0 -1.3 -2.2 -1.0 1.0 -2.0
Leg fat percentage (left) 0.4 1.6 4.3 1.9 0.2 0.3 -2.1 -0.2 0.0 -1.7
Arm fat-free mass (left) 0.3 1.4 3.1 0.2 -0.8 -1.1 -1.8 -1.1 0.6 -1.8
Number of operations (self-reported) 1.3 2.0 6.3 1.1 1.9 2.5 -0.2 0.1 -1.6 -0.1
Average weekly beer plus cider intake 1.7 2.5 5.4 -1.5 -0.7 0.9 1.3 2.3 -2.0 1.7
Irritability 2.9 4.9 7.3 -1.5 0.6 2.7 2.6 2.5 -2.3 2.5
Risk taking 1.3 1.9 5.6 -1.1 0.5 0.6 2.4 0.5 -0.9 2.2
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.3 0.8 0.3 -0.5 -0.1 0.7 0.1
Fractured/broken bones in last 5 years 0.6 0.8 2.9 -0.6 -1.1 -1.7 0.1 0.1 1.0 -0.1
Age started oral contraceptive pill 1.5 1.9 6.7 -0.1 -2.6 -1.4 -1.1 -0.0 1.8 -0.4
Diastolic blood pressure, automated reading 0.5 1.5 4.9 2.2 0.9 -0.4 -1.1 -0.8 0.1 -1.6
Ever depressed for a whole week 0.7 0.9 1.9 1.2 1.4 1.3 -0.1 0.2 -0.9 -0.6
Unable to work because of sickness or disability 0.2 0.2 0.8 -0.2 -0.9 0.1 -0.1 -0.8 0.4 -0.2
Commuting to job workplace: Cycle 0.2 0.2 0.6 -0.7 -0.6 -0.8 0.2 -0.1 0.3 0.3
Myopia 1.0 1.5 4.4 -0.4 -1.2 -1.4 -1.1 -0.7 2.1 -0.7
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.8 -0.3 -0.6 -0.2 0.8 1.7 -0.6 0.9
Cholesterol lowering medication 0.6 0.9 2.8 0.2 0.5 0.9 0.3 1.7 -1.0 1.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 2.6 1.6 0.4 0.9 -0.9 -0.0 -0.1 -0.1
Pain experienced in last month 2.2 3.6 9.6 -2.1 -3.1 -2.1 0.1 -1.5 1.9 -1.0
Supplements: Calcium 1.3 1.4 4.3 0.2 1.7 2.1 1.2 -0.2 -0.9 0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.1 -0.5 0.7 0.2 0.5 0.4 0.4
Heart attack/myocardial infarction (self-reported) 0.9 1.2 5.0 -0.4 2.2 1.0 -0.5 -0.7 -1.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.4 0.6 0.5 0.9 0.4 -0.7 0.7
Heart disease (siblings) 0.8 1.0 2.1 1.1 1.1 1.4 -0.6 -1.4 0.0 -0.4
Alcohol drinker status: Previous 0.6 0.7 2.6 1.6 0.8 0.3 -1.0 -0.1 -0.7 -0.1
Pack years of smoking 1.0 1.4 2.8 0.9 -0.1 1.1 1.7 1.2 -1.0 1.5
Impedance of whole body 0.2 0.9 3.1 0.0 -1.7 -0.4 -0.1 1.5 0.6 0.8
Leg fat mass (left) 0.4 1.7 5.0 1.7 -0.1 0.1 -2.2 -0.4 0.3 -1.9
Arm predicted mass (left) 0.3 1.7 4.0 0.3 -0.5 -1.1 -2.0 -1.3 0.9 -2.0