TWAS hub - CNIH

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0191	0.0077	0.00320	0.006	0.007	0.001	0.007	0.003	0.00410	2.2e-03	1.8e-01	0.0021	3.4e-02
2	TCGA	Brain Lower Grade Glioma	0.0258	0.0144	0.00024	0.024	0.019	0.015	NA	0.019	0.00090	2.6e-03	7.0e-03	NA	2.9e-03
3	TCGA	Prostate Adenocarcinoma	0.0298	0.0167	0.00021	0.047	0.042	0.040	NA	0.045	0.00001	3.3e-05	4.8e-05	NA	1.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Co-codamol	8.7	10.1	10.9	3.3	3.3	-2.9
Medication: Atorvastatin	7.5	9.3	10.7	3.3	2.9	-2.9
Number of operations (self-reported)	7.3	10.8	15.0	3.3	3.9	-2.6
Alzheimer’s Disease (in mother)	6.7	7.9	10.0	-2.4	-3.2	2.8
Angina	5.7	7.5	11.8	2.5	3.4	-2.1
Angina (self-reported)	5.7	7.5	11.7	2.6	3.4	-2.0
Wears glasses or contact lenses	4.6	5.3	6.7	-2.6	-2.3	2.0
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	7.5	1.9	2.7	-2.7
High blood pressure (siblings)	3.8	5.4	6.5	2.5	2.1	-2.3
Number of self-reported non-cancer illnesses	3.7	6.3	7.4	2.3	2.7	-2.5
Impedance of leg (right)	3.6	17.4	28.6	5.4	3.7	-3.2
Illnesses of siblings	3.6	5.1	5.8	-2.1	-2.2	2.4
Tinnitus: Yes, but not now, but have in the past	3.5	3.7	4.8	-1.7	-2.2	1.8
Pulse wave reflection index	3.4	4.2	5.6	1.9	2.4	-1.8
Supplements: Fish oil (including cod liver oil)	3.4	4.4	5.2	2.3	2.1	-1.9
Had other major operations	3.1	3.7	5.2	1.9	2.3	-1.6
Alzheimer’s Disease (including proxy)	3.0	4.3	5.6	-1.7	-2.1	2.4
Ever had hysterectomy (womb removed)	3.0	3.4	3.8	1.9	1.7	-1.9
Vitamin and mineral supplements	3.0	4.0	5.1	-2.3	-1.8	1.9
Fed-up feelings	3.0	5.4	6.4	2.5	2.5	-1.9
Worry too long after embarrassment	3.0	5.0	8.5	2.9	2.1	-1.4
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	6.8	1.3	2.6	-1.7
Risk taking	2.9	4.2	6.6	2.6	2.2	-1.2
Relative age voice broke	2.8	4.3	6.2	-2.5	-2.1	1.5
Medication: Ventolin 100micrograms inhaler	2.8	3.6	4.1	-1.9	-2.0	1.8
Multivitamins +/- minerals	2.7	3.4	4.6	2.1	2.1	-1.1
Chest pain or discomfort	2.7	3.9	6.4	1.6	2.5	-1.6
Pulse wave Arterial Stiffness index	2.6	3.0	4.1	1.2	2.0	-1.9
Impedance of arm (left)	2.6	11.8	19.1	4.4	3.1	-2.5
Ever had prostate specific antigen (PSA) test	2.6	3.1	4.6	-1.5	-1.5	2.1
Impedance of whole body	2.6	13.4	22.9	4.8	3.2	-2.6
Loneliness, isolation	2.5	3.5	6.3	1.5	2.5	-1.4
Maternal smoking around birth	2.4	3.5	3.9	1.6	2.0	-2.0
Pain experienced in last month	2.4	3.9	6.1	-2.5	-1.0	2.1
Fasting Glucose	2.3	2.8	3.4	1.8	1.6	-1.5
Diabetes (father)	2.3	2.9	4.0	1.4	2.0	-1.6
Impedance of leg (left)	2.2	10.5	19.2	4.4	2.7	-2.3
Impedance of arm (right)	2.2	10.1	18.8	4.3	2.6	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	8.5	-0.8	-2.2	2.9
Relative age of first facial hair	2.1	4.3	6.6	-2.6	-2.3	1.1
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.7	-1.9	-1.8	0.5
Had major operations	2.0	2.4	3.1	1.0	1.7	-1.7
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	4.2	2.1	1.4	-1.8
Schizophrenia (2018)	1.9	3.9	4.3	1.9	2.1	-1.9
Neuroticism (2016)	1.9	2.7	4.1	2.0	2.0	-0.0
Ever used hormone-replacement therapy (HRT)	1.9	2.4	3.1	1.8	1.6	-1.3
Supplements: Vitamin C	1.9	2.2	4.8	1.1	0.8	-2.2
Past tobacco smoking	1.8	3.3	3.6	-1.9	-1.8	1.7
Eye problems/disorders: Glaucoma	1.8	2.1	2.7	-1.0	-1.6	1.7
Cholesterol lowering medication	1.8	2.7	4.0	1.8	0.9	-2.0
Triglycerides	1.7	2.8	5.3	-0.2	1.8	-2.3
Waist Hip Ratio (WHR)	1.7	7.7	10.9	3.0	3.3	-1.9
Smoking Status	1.7	4.2	6.6	1.3	2.0	-2.6
Neuroticism score	1.7	3.6	5.0	2.0	2.2	-1.3
Father’s age at death	1.7	2.2	4.3	-0.9	-1.3	2.1
Emphysema/chronic bronchitis	1.7	1.9	2.8	1.5	1.7	-0.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.3	-2.3	-0.8	0.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.3	-0.5	-1.5	1.8
Back pain experienced in last month	1.6	2.3	4.1	2.0	0.5	-1.6
Townsend deprivation index at recruitment	1.5	2.2	3.3	1.8	1.2	-1.3
Pulse wave peak to peak time	1.5	1.8	2.6	-0.8	-1.6	1.5
Eye problems/disorders: None of the above	1.5	1.7	2.4	1.6	1.3	-1.0
Smoking status: Previous	1.5	2.3	2.8	1.7	1.5	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	2.7	-0.4	1.5	-1.6
Mineral and other dietary supplements	1.5	2.1	2.9	-1.7	-1.2	1.4
Taking other prescription medications	1.4	2.1	3.3	1.8	1.4	-1.0
Overall health rating	1.4	3.1	3.9	2.0	1.6	-1.7
Mother’s age at death	1.4	1.7	2.5	-0.9	-1.6	1.4
Fractured/broken bones in last 5 years	1.4	1.8	2.6	1.6	1.6	-0.6
Sensitivity / hurt feelings	1.3	2.3	3.3	1.5	1.8	-1.1
Length of working week for main job	1.3	1.4	2.2	0.4	1.5	-1.4
Glaucoma (self-reported)	1.3	1.6	2.8	-0.9	-1.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.1	1.8	0.6	-1.1
Medication: Seretide 50 evohaler	1.3	1.5	2.7	-0.6	-1.6	1.1
Age at last live birth	1.3	1.8	2.3	-1.2	-1.5	1.4
Neuroticism (Nagel 2018)	1.2	2.7	3.3	1.4	1.8	-1.7
HDL Cholesterol	1.2	2.0	3.4	-0.3	-1.8	1.6
Sitting height	1.2	8.2	17.3	-4.2	-1.6	2.2
Medication: Omeprazole	1.2	1.4	3.6	-0.1	-0.8	1.9
Heart disease (mother)	1.2	1.5	2.1	0.4	1.5	-1.4
Medication: Bendroflumethiazide	1.2	1.8	2.1	-1.3	-1.5	1.3
Bipolar Disorder (2018)	1.1	1.7	3.4	-1.0	-1.8	0.8
Bipolar Disorder (2011)	1.1	1.1	2.6	-1.6	-0.8	0.1
Stomach or abdominal pain in last month	1.1	1.3	2.3	0.9	1.0	-1.5
Had menopause	1.1	1.4	1.9	1.4	1.0	-1.2
Exposure to tobacco smoke outside home	1.1	1.5	3.5	-0.0	1.9	-1.0
Illnesses of siblings: Diabetes	1.1	1.4	2.4	1.0	1.6	-0.9
Guilty feelings	1.1	1.7	3.3	1.8	1.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.5	0.1	-0.7	1.9
Heel T-Score	1.0	8.2	16.9	1.0	2.6	-4.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.6	0.7	1.6	-1.0
Hair/balding pattern: Pattern 4	1.0	2.5	3.6	1.5	1.3	-1.9
Neck or shoulder pain in last month	1.0	1.5	2.1	1.5	0.8	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.2	-0.7	-1.5	1.0
Hypertension (Self-reported)	1.0	2.8	3.3	1.8	1.6	-1.6
Ever had bowel cancer screening	1.0	1.2	3.1	-0.4	-0.7	1.8
Average weekly beer plus cider intake	1.0	1.4	2.4	0.8	1.6	-1.1
Ovarian Cancer	0.9	1.2	2.4	1.6	1.0	-0.2
Body Mass Index (BMI) (2010)	0.9	1.2	1.5	-0.9	-1.1	1.2
Systolic blood pressure, automated reading	0.9	2.5	4.1	0.6	2.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.4	-0.2	0.7	-2.3
Serious illness, injury or assault to yourself	0.9	1.1	2.2	-1.5	-0.8	0.7
High blood pressure (mother)	0.9	1.2	2.9	1.7	0.5	-0.7
Nervous feelings	0.9	1.6	3.0	1.7	1.2	-0.6
Mouth/teeth dental problems	0.9	1.4	1.6	-1.1	-1.2	1.3
Trunk fat-free mass	0.9	5.2	11.5	-3.4	-1.3	1.6
Mouth/teeth dental problems: Dentures	0.9	1.5	2.9	1.1	1.7	-0.7
Trunk predicted mass	0.9	5.0	11.1	-3.3	-1.3	1.6
Birth weight	0.9	2.0	3.5	-0.6	-1.4	1.9
Number of full brothers	0.9	1.2	2.2	1.5	1.0	-0.5
Arm predicted mass (right)	0.9	4.5	9.6	-3.1	-1.1	1.6
Leg fat-free mass (right)	0.9	4.8	9.5	-3.1	-1.3	1.7
Osteoarthritis (self-reported)	0.9	1.2	3.1	0.7	1.8	-0.1
Whole body water mass	0.9	5.0	10.4	-3.2	-1.3	1.7
Leg predicted mass (right)	0.9	5.0	9.8	-3.1	-1.4	1.8
Diastolic blood pressure, automated reading	0.9	2.7	4.3	1.2	2.1	-1.5
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.7	-1.9	-1.5	1.2
Lung FEV1/FVC ratio	0.8	3.8	6.1	-1.5	-1.8	2.5
Alcohol usually taken with meals	0.8	1.3	2.8	0.3	1.0	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.3	1.5	0.9	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	-0.5	-0.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.6	0.3	1.0	-2.1
Qualifications: None of the above	0.8	1.7	2.8	1.7	1.6	-0.1
Lung cancer (father)	0.8	0.9	1.0	1.0	1.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.2	0.0	1.1	-1.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.0	1.1	1.4	-1.2
Arm fat-free mass (right)	0.8	4.0	8.6	-2.9	-1.0	1.5
Number of full sisters	0.8	0.9	1.7	0.9	1.3	-0.5
Leg pain on walking	0.8	1.0	2.5	1.6	0.7	-0.0
Whole body fat-free mass	0.8	4.6	9.9	-3.1	-1.2	1.6
Illnesses of father: High blood pressure	0.8	1.0	2.8	0.2	0.5	-1.7
Arm fat-free mass (left)	0.8	4.0	8.3	-2.9	-1.2	1.5
Basal cell carcinoma (self-reported)	0.8	0.9	1.4	-1.2	-0.8	0.8
Depressed Affect (Nagel 2018)	0.7	1.5	2.0	0.8	1.4	-1.3
Mean Putamen Volume	0.7	0.8	1.1	0.7	0.9	-1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.0	0.9	0.8	-1.0
Blood White Count	0.7	5.3	6.9	1.6	2.5	-2.6
Systolic Blood Pressure	0.7	3.5	5.7	0.5	2.2	-2.4
Allergy or Eczema	0.7	1.9	3.9	-1.3	-0.4	2.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	0.1	-1.1	1.1
Supplements: Zinc	0.7	0.8	1.1	1.1	1.1	-0.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.4	-1.8	-0.0	1.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	-0.9	-0.6	-1.1
Loud music exposure frequency	0.7	0.7	1.6	-0.3	0.7	-1.3
Family relationship satisfaction	0.7	0.9	1.5	-0.3	-1.0	1.2
Knee pain experienced in last month	0.7	1.1	2.5	1.6	0.6	-0.6
Diabetes diagnosed by doctor	0.7	1.1	1.9	0.9	1.4	-0.7
Irritability	0.7	1.2	1.9	0.9	1.4	-0.9
Arm predicted mass (left)	0.7	3.7	8.0	-2.8	-1.0	1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.3	0.9	1.1	-0.6
Lung FVC	0.6	3.3	7.1	0.0	-2.7	1.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	0.8	1.3	-0.6
Medication: Levothyroxine sodium	0.6	1.1	1.5	0.8	1.2	-1.0
Number of incorrect matches in round	0.6	1.0	1.8	1.4	1.0	-0.4
Medication: Cholesterol lowering	0.6	0.9	1.7	1.3	1.0	-0.0
Medication: Blood pressure	0.6	1.0	1.7	1.0	1.3	-0.6
Medication: Aspirin	0.6	0.8	1.1	0.8	0.8	-1.1
Miserableness	0.6	1.0	1.5	-0.6	1.0	-1.2
Ever smoked	0.6	1.0	1.3	1.1	0.9	-1.0
Basal metabolic rate	0.6	3.4	7.6	-2.7	-1.0	1.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	0.7	1.3	-0.9
Number of treatments/medications taken	0.5	1.0	1.4	1.2	1.2	-0.4
Age when periods started (menarche)	0.5	1.3	2.3	-0.3	-1.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	-0.3	0.9	-0.8
High blood pressure	0.5	1.5	2.6	1.6	0.9	-1.1
Leg predicted mass (left)	0.5	2.6	5.6	-2.4	-0.8	1.2
Diabetes (self-reported)	0.5	0.8	1.3	0.6	1.1	-0.8
Worrier / anxious feelings	0.5	0.9	1.6	1.3	1.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	1.1	0.6	-0.5
Depression (self-reported)	0.5	0.6	1.1	-1.1	-0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.6	-1.3	-1.0	0.1
Age at first live birth	0.5	0.9	1.1	-1.1	-0.9	0.9
Health satisfaction	0.5	0.7	1.8	1.3	0.5	-0.3
Mean time to correctly identify matches	0.5	0.9	1.3	-1.1	-0.6	1.1
Comparative height size at age 10	0.5	2.8	5.1	0.5	2.3	-1.7
Long-standing illness, disability or infirmity	0.5	0.7	1.5	0.3	0.7	-1.2
Medication: Gliclazide	0.5	0.6	1.8	-1.4	0.2	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	0.0	-0.3	1.3
Alcohol drinker status: Previous	0.5	0.5	0.9	0.7	0.9	-0.5
Coronary Artery Disease (CAD)	0.4	0.5	0.7	0.1	-0.8	0.8
Schizophrenia (2014)	0.4	0.8	1.1	0.5	1.0	-1.0
Blood Eosinophil Count	0.4	3.0	5.7	0.6	1.7	-2.4
Medication: Metformin	0.4	0.5	1.2	0.2	1.1	-0.6
Pack years adult smoking proportion	0.4	0.7	1.0	-1.0	0.3	-1.0
Leg fat-free mass (left)	0.4	2.4	5.2	-2.3	-0.7	1.2
Supplements: Glucosamine	0.4	0.6	1.4	1.2	-0.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.7	0.9	-0.4
Allergy	0.4	1.0	2.1	1.4	-0.1	-0.9
Time employed in main current job	0.4	0.5	1.2	1.1	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.6	0.7	-0.6	0.8
Leg fat percentage (right)	0.4	1.4	1.9	1.4	1.1	-1.0
Alcohol intake frequency.	0.4	0.9	1.2	1.0	1.1	-0.7
Medication: Aspirin	0.4	0.6	0.9	1.0	0.5	-0.8
Average weekly red wine intake	0.4	0.5	0.6	-0.8	-0.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	0.9	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	0.8	0.7	-0.7
Pack years of smoking	0.4	0.6	1.1	-1.0	0.2	-0.8
Bipolar Disorder or Schizophrenia	0.3	0.6	1.0	0.8	0.4	-1.0
Crohns Disease (2017)	0.3	0.8	1.6	-1.2	-0.7	-0.4
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	-1.3	-0.8	-0.1
Age at First Birth	0.3	0.5	0.7	0.6	-0.6	0.9
Crohns Disease (2012)	0.3	0.4	0.9	-0.9	-0.3	-0.5
BMI	0.3	1.9	3.0	-1.7	-1.2	1.2
Average weekly spirits intake	0.3	0.3	0.9	1.0	0.1	-0.1
Trunk fat percentage	0.3	1.0	1.5	1.2	1.0	-0.7
Current tobacco smoking	0.3	0.5	1.2	0.1	0.5	-1.1
Body mass index (BMI)	0.3	1.3	2.4	-1.5	-1.1	0.7
Financial difficulties in last 2 years	0.3	0.4	0.9	0.9	0.3	-0.5
Fluid intelligence score	0.3	0.6	1.6	-0.5	-0.0	1.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	-0.4	-1.0	0.1
Number of live births	0.3	0.4	0.7	0.6	0.2	-0.8
Prospective memory result	0.3	0.4	1.1	0.3	0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.1	0.4	-0.8	1.4
Breastfed as a baby	0.3	0.4	1.2	1.1	-0.1	0.1
Tense / ‘highly strung’	0.3	0.5	0.6	0.8	0.6	-0.7
Gout (self-reported)	0.3	0.4	0.6	-0.7	0.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.4	0.3	-0.9
Friendships satisfaction	0.3	0.4	0.6	-0.8	-0.4	0.6
Medication for cholesterol	0.3	0.4	1.3	-0.2	0.0	1.1
Breast cancer (self-reported)	0.3	0.3	0.5	-0.7	-0.6	-0.4
Hearing aid user	0.3	0.3	0.6	-0.2	0.7	-0.6
Medication: Blood pressure	0.3	0.5	1.3	-0.3	-0.5	-1.1
High cholesterol (Self-reported)	0.3	0.6	1.4	1.2	-0.3	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	0.3	0.2
Major Depression (MDD)	0.2	0.2	0.5	-0.7	0.4	-0.1
Reaction Time	0.2	0.3	0.8	-0.9	-0.2	0.3
LDL Cholesterol	0.2	0.3	0.8	-0.9	-0.2	-0.1
Lupus	0.2	0.4	0.5	0.7	0.2	-0.7
Ulcerative Colitis	0.2	0.2	0.7	-0.8	-0.1	-0.2
Blood Platelet Count	0.2	1.7	4.1	-0.7	0.8	-2.0
Neuroticism	0.2	0.4	0.8	0.3	0.9	-0.4
Chronotype (morning person)	0.2	0.4	0.6	-0.8	0.6	-0.6
Tanning	0.2	2.4	3.8	-2.0	-1.3	1.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.7	0.3	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	0.2	-0.1
Diabetes (mother)	0.2	0.2	0.5	-0.7	-0.3	0.2
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.1	-0.7	-0.5
Medication: Atenolol	0.2	0.2	0.3	-0.6	0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.1	-0.1	0.8
Heart attack	0.2	0.3	0.4	0.3	0.6	0.7
Pain all over the body in last month	0.2	0.3	0.7	0.9	0.2	0.2
Medication: Simvastatin	0.2	0.2	0.5	0.0	-0.7	0.5
Weight	0.2	1.0	2.6	-1.6	-0.3	0.4
Hip circumference	0.2	0.8	2.2	-1.5	-0.4	0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.2	0.7	-0.5
Happiness	0.2	0.2	0.4	-0.4	-0.1	0.6
Asthma	0.2	0.3	0.4	-0.7	-0.3	0.6
Exposure to tobacco smoke at home	0.2	0.3	0.4	-0.4	0.7	-0.4
Birth weight of first child	0.2	0.3	0.8	0.9	0.1	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.5	0.4	-0.8
Blood clot in the leg (DVT)	0.2	0.3	0.4	0.6	0.4	-0.6
Medication: Paracetamol	0.2	0.4	0.5	0.7	0.7	-0.4
Headache pain in last month	0.2	0.3	0.5	0.4	-0.7	-0.4
Medication: Amlodipine	0.2	0.3	1.0	1.0	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.8	0.0	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.3	0.1	-1.0	1.1
Body fat percentage	0.2	0.7	1.2	1.1	0.8	-0.6
Comparative body size at age 10	0.2	0.6	0.9	-0.9	-0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.9	0.1	-0.3
Number of children fathered	0.2	0.3	0.6	-0.8	-0.4	0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.9	-0.2	0.1
Migraine (self-reported)	0.2	0.3	0.6	0.2	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	-0.3	-0.7	0.7
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.2	0.7	-0.3
Smoking status: Current	0.2	0.4	0.9	0.1	0.4	-0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.0	-0.6	0.7
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.7	0.2	-0.5
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.5	-0.3	0.5
Alcohol drinker status: Never	0.2	0.2	0.5	-0.7	0.1	0.5
Ever depressed for a whole week	0.2	0.3	0.5	0.5	0.7	-0.2
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.2	-0.4	0.8
Myopia	0.2	0.2	0.6	0.2	0.7	-0.4
Supplements: Calcium	0.2	0.2	0.5	0.7	0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.1	0.5	0.7
Depression (Nagel 2018)	0.1	0.2	0.3	-0.1	0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.5	0.8	0.3	0.9	0.7
Worry (Nagel 2018)	0.1	0.3	0.6	0.0	0.5	-0.8
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	-0.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	-0.4	0.4	0.5
Breast Cancer	0.1	0.3	0.6	0.3	0.8	0.3
HbA1C	0.1	0.1	0.2	-0.3	-0.4	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.1	-0.3	-0.6
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.1	-0.4
Height	0.1	2.3	3.5	-1.4	1.9	-1.2
Hypothyroidism (self reported)	0.1	0.1	0.3	-0.5	0.2	0.3
Respiratory disease	0.1	0.3	0.6	0.8	0.5	0.2
Hair Pigment	0.1	2.4	3.2	1.6	1.8	-1.3
Severe depression (siblings)	0.1	0.1	0.2	0.5	0.5	-0.0
Trunk fat mass	0.1	0.2	0.5	0.3	0.7	-0.3
Waist circumference	0.1	0.4	0.7	0.0	0.8	-0.7
Medication: Ramipril	0.1	0.1	0.2	-0.5	0.1	0.2
Falls in the last year	0.1	0.1	0.2	-0.1	-0.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	0.5	0.2	0.5
Pulse rate	0.1	0.2	0.5	-0.7	-0.3	0.3
Noisy workplace	0.1	0.1	0.2	-0.5	-0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.7	-0.1	0.5
Medication: Lansoprazole	0.1	0.1	0.3	0.3	-0.2	-0.5
Arm fat mass (right)	0.1	0.3	0.5	-0.7	-0.6	0.5
Standing height	0.1	1.1	2.5	-0.5	1.6	-0.7
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.7	0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.3	0.5	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.2	0.4	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.3	0.4	0.5	0.0
Qualifications: College or University degree	0.1	0.4	1.0	-1.0	0.3	0.3
Pulse rate, automated reading	0.1	0.3	0.4	0.5	0.6	-0.5
Suffer from ‘nerves’	0.1	0.1	0.2	-0.2	0.4	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.5	0.2	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.4	0.7	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.2	-0.4	0.2
Mood swings	0.1	0.2	0.4	0.3	0.6	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	0.1	0.1
Asthma (self-reported)	0.1	0.1	0.3	-0.5	0.0	0.2
Arm fat mass (left)	0.1	0.3	0.6	-0.8	-0.5	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.4	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.5	-0.4	-0.2
Medication: Lisinopril	0.1	0.2	0.4	0.3	0.1	-0.6
Leg fat percentage (left)	0.1	0.2	0.3	0.6	0.3	-0.4
Age started oral contraceptive pill	0.1	0.2	0.3	-0.3	0.3	0.6
Unable to work because of sickness or disability	0.1	0.2	0.5	0.1	-0.7	0.1
Heart disease (siblings)	0.1	0.1	0.3	-0.6	0.1	0.2
Prostate Cancer	0.0	0.0	0.0	-0.1	0.2	-0.2
Blood Red Count	0.0	0.2	0.2	-0.5	-0.1	0.5
Cardiovascular Disease	0.0	0.2	0.3	0.6	-0.1	-0.4
Hand grip strength (left)	0.0	0.0	0.0	-0.2	0.1	-0.1
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.1	0.4	0.0
Hand grip strength (right)	0.0	0.1	0.1	-0.2	0.2	-0.3
Average weekly fortified wine intake	0.0	0.0	0.0	-0.2	-0.2	0.0
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.4	-0.1	-0.1
Forced vital capacity (FVC)	0.0	0.2	0.4	0.7	0.3	-0.1
Arm fat percentage (right)	0.0	0.0	0.1	0.3	-0.2	-0.0
Illnesses of mother	0.0	0.0	0.0	-0.2	0.0	0.2
Medication: Ibuprofen	0.0	0.0	0.0	0.2	-0.0	0.1
Medication: Allopurinol	0.0	0.0	0.0	-0.0	-0.2	-0.1
Whole body fat mass	0.0	0.0	0.1	-0.1	0.3	0.1
Leg fat mass (right)	0.0	0.1	0.2	-0.0	0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.1	0.0	0.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.0	0.1	-0.0
Arm fat percentage (left)	0.0	0.1	0.2	0.4	0.1	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.2	0.1	-0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.3	0.1	-0.1
Medication: Paracetamol	0.0	0.0	0.1	-0.1	-0.2	0.3
Leg fat mass (left)	0.0	0.1	0.2	-0.4	-0.0	0.2

Hub : Genes

CNIH

Models

Trait associations