Hub : Genes

CNOT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1430	0.050	1.8e-03	0.168	NA	0.153	NA	0.163	2.0e-08	NA	9.4e-08	NA	3.3e-08
2	NTR	Blood	0.0566	0.013	1.9e-13	0.061	0.045	0.062	0.028	0.000	5.2e-19	2.7e-14	2.4e-19	1.9e-09	3.4e-01
3	YFS	Blood	0.0952	0.017	0.0e+00	0.122	0.106	0.115	0.120	0.119	1.0e-37	1.2e-32	1.2e-35	4.0e-37	9.7e-37
4	TCGA	Colon Adenocarcinoma	0.0480	0.026	4.8e-03	0.050	0.036	0.030	NA	0.033	7.4e-04	3.5e-03	7.6e-03	NA	5.3e-03
5	TCGA	Rectum Adenocarcinoma	0.2840	0.133	4.9e-03	0.044	0.028	0.047	NA	0.030	3.4e-02	7.4e-02	2.9e-02	NA	6.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	3.8	6.0	9.8	2.4	-2.8	1.9	3.1	1.6
Bipolar Disorder or Schizophrenia	7.2	17.5	25.4	4.8	-5.0	3.0	4.4	3.3
Depressed Affect (Nagel 2018)	1.3	2.7	4.2	1.6	-1.4	2.0	0.8	2.0
Depression (Nagel 2018)	3.3	5.0	6.7	2.4	-2.3	2.1	1.7	2.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.5	0.8	-0.0	-1.1	-0.3
Neuroticism (Nagel 2018)	1.3	3.1	4.5	1.9	-2.1	1.7	1.5	1.4
Schizophrenia (2018)	5.5	11.5	17.4	4.0	-4.2	2.3	3.1	3.0
Schizophrenia vs Biploar Disorder	2.9	3.8	6.0	2.0	-2.4	1.3	1.3	2.4
Worry (Nagel 2018)	1.1	2.3	5.1	1.3	-2.2	0.2	2.1	0.4
Alzheimer’s Disease (in mother)	1.8	2.1	4.8	-1.5	2.2	-1.0	-1.6	0.1
Alzheimer’s Disease (in father)	1.5	1.7	3.1	-1.7	1.8	0.4	-1.4	0.2
Alzheimer’s Disease (including proxy)	1.8	2.6	5.8	-1.9	2.4	-0.4	-1.7	0.5
Crohns Disease (2017)	0.6	1.2	1.9	1.1	-1.0	0.7	1.3	1.4
Irritable Bowel Disease (IBD)	1.2	3.0	4.4	1.2	-1.5	2.0	1.6	2.1
Ulcerative Colitis (UC)	1.6	3.1	7.5	0.9	-1.3	2.7	1.2	2.0
Major Depression (MDD)	0.1	0.2	0.2	-0.4	-0.4	-0.5	0.4	-0.2
Reaction Time	0.2	0.3	1.4	0.0	-0.3	1.2	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.9	-1.2	2.2	-0.4	-2.2	-0.2
Breast Cancer	1.4	3.3	5.5	2.3	-2.3	1.9	1.1	1.0
Ovarian Cancer	0.9	1.2	3.3	-0.6	1.3	0.6	-1.8	-0.6
Prostate Cancer	0.1	0.2	0.6	-0.4	0.4	0.2	-0.8	0.2
Age at First Birth	2.2	3.2	6.4	1.6	-2.1	0.5	2.5	1.5
Bipolar Disorder (2011)	1.7	1.7	2.9	0.0	-1.6	1.7	1.7	0.0
Body Mass Index (BMI) (2010)	1.6	2.2	2.9	1.7	-1.7	1.1	1.6	1.3
Coronary Artery Disease (CAD)	4.0	4.7	6.7	-2.2	2.2	-1.2	-2.4	-2.6
Crohns Disease (2012)	0.2	0.3	0.5	0.7	-0.4	-0.2	0.6	0.5
Mean Putamen Volume	1.9	2.2	5.2	1.2	-1.8	2.3	0.6	0.7
Fasting Glucose	0.1	0.2	0.7	0.2	0.3	-0.0	-0.8	-0.2
HbA1C	1.2	1.4	2.1	-0.9	1.1	1.4	-1.0	-1.3
HDL Cholesterol	0.1	0.2	0.4	0.2	-0.5	0.5	0.5	0.6
LDL Cholesterol	0.1	0.1	0.4	-0.5	0.2	0.1	-0.6	-0.2
Lupus	0.2	0.3	0.6	0.3	0.0	0.8	-0.7	-0.5
Neuroticism (2016)	0.5	0.8	1.9	0.2	-0.1	1.3	-0.6	1.4
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.6	-0.9	0.8	0.4	0.8
Rheumatoid Arthritis	0.5	0.7	1.0	-1.0	0.9	-0.9	-0.8	-0.3
Schizophrenia (2014)	5.6	12.3	17.3	3.9	-4.2	2.3	3.6	3.3
Triglycerides	0.2	0.3	1.0	0.5	0.0	0.3	-0.2	1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.3	-2.1	0.8	-0.5	-0.7	-0.7
Ulcerative Colitis	2.4	3.5	6.8	1.3	-1.6	2.6	1.7	1.8
Blood Eosinophil Count	0.2	1.6	2.8	-1.7	1.3	-0.1	-1.0	-1.6
Blood Platelet Count	1.2	13.9	23.9	-3.6	4.0	-4.9	-2.7	-3.0
Blood Red Count	1.5	14.2	22.6	3.6	-4.8	3.8	4.0	2.4
Blood White Count	0.1	0.5	1.1	-0.9	0.8	-1.0	0.1	-0.1
Heel T-Score	0.0	0.1	0.2	-0.5	0.1	-0.5	-0.3	-0.3
BMI	0.6	3.4	12.4	0.7	-1.6	3.5	1.3	0.1
Height	0.3	6.5	20.6	1.8	-1.3	4.5	0.4	2.7
Waist Hip Ratio (WHR)	1.2	5.5	9.4	-2.4	3.1	-2.1	-2.4	-1.6
Systolic Blood Pressure	1.0	4.9	11.4	1.1	-2.2	3.4	1.6	2.1
Smoking Status	0.7	1.6	2.7	1.6	-0.4	1.6	0.4	1.5
Allergy or Eczema	0.7	1.8	2.8	1.6	-1.4	1.7	0.8	0.9
Cardiovascular Disease	0.2	0.5	1.8	0.4	-1.3	-0.1	0.8	0.2
Hypothyroidism (self reported)	0.4	0.9	2.2	0.3	-0.8	0.9	1.5	0.9
Respiratory disease	0.4	1.0	2.0	0.8	-1.4	1.3	0.6	0.3
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.9	1.4	-1.6	2.4	1.4	0.7
Lung FEV1/FVC ratio	0.2	1.1	3.0	-0.4	-1.0	-1.1	1.7	0.5
Lung FVC	0.2	1.3	2.1	1.0	-1.1	-1.4	1.4	0.0
Neuroticism	0.4	0.9	2.0	0.7	-1.2	1.4	0.6	0.3
Chronotype (morning person)	0.5	1.2	2.9	1.7	-1.5	0.8	0.7	0.2
Hair Pigment	0.1	4.2	7.1	2.7	-2.2	1.1	2.5	1.2
Tanning	0.0	0.6	1.5	-0.8	1.2	-0.3	-0.7	0.5
Hand grip strength (left)	2.0	5.3	7.3	2.0	-2.5	2.7	2.3	1.9
Number of treatments/medications taken	1.1	2.0	4.1	0.6	-1.9	2.0	1.3	0.4
Average weekly spirits intake	2.5	3.1	6.0	-1.8	1.2	-0.5	-2.2	-2.5
Sensitivity / hurt feelings	0.3	0.6	1.3	-1.2	0.9	0.2	-0.8	-0.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.3	1.3	-0.9	1.8	0.8	1.4
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.4	0.3	-0.2	-0.8	-0.2
Relative age of first facial hair	0.4	0.8	1.6	1.3	-1.2	-0.2	1.0	0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.5	-1.1	0.9	1.2	-1.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.4	-0.7	-0.8	0.5	-0.6
Ever had hysterectomy (womb removed)	2.1	2.4	5.3	-2.3	1.6	0.7	-1.6	-1.0
Systolic blood pressure, automated reading	0.9	2.5	8.3	0.8	-1.3	2.9	0.7	1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	0.3	0.1	0.2	-0.6	-1.3
Angina	3.3	4.3	8.1	-2.1	1.9	0.3	-2.8	-2.4
Medication for hormone replacement therapy	1.1	1.2	3.0	1.2	-1.4	0.1	1.7	0.0
Vitamin and mineral supplements	0.3	0.5	0.7	-0.9	0.6	0.7	-0.6	0.6
Supplements: Zinc	2.9	3.1	5.4	2.3	-1.5	1.4	1.9	1.6
Medication: Co-codamol	0.4	0.5	1.0	0.8	-0.9	-0.2	1.0	0.1
Medication: Metformin	1.1	1.6	2.8	0.9	-1.0	1.1	1.7	1.4
Diabetes (father)	0.5	0.6	1.3	0.4	-0.9	1.1	0.9	0.5
Diabetes (mother)	1.7	2.2	5.0	-1.0	1.3	1.6	-2.2	0.7
Severe depression (siblings)	4.5	5.0	7.7	2.8	-2.7	1.4	2.7	0.7
Pack years adult smoking proportion	0.6	0.9	3.2	-0.4	0.7	1.8	-0.8	-0.0
Impedance of leg (right)	1.1	5.2	10.7	-1.6	2.7	-3.3	-2.2	-0.4
Leg fat-free mass (left)	1.2	6.2	24.2	0.8	-1.9	4.9	1.4	0.8
Trunk fat percentage	0.6	2.4	4.5	-1.6	1.3	2.1	-1.7	-0.6
Hand grip strength (right)	0.8	2.2	3.9	1.3	-1.4	2.0	1.1	1.5
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.4	-0.2	0.6	-0.1	-0.6
Current tobacco smoking	1.0	1.7	4.4	1.4	-0.4	2.1	0.3	1.3
Average weekly fortified wine intake	0.4	0.5	1.6	-0.6	0.4	-0.3	-0.5	-1.3
Maternal smoking around birth	0.5	0.8	1.7	1.0	-0.3	1.3	0.4	1.0
Fed-up feelings	0.4	0.7	1.7	0.5	-0.4	1.3	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	4.2	2.0	-2.0	1.8	1.7	1.3
Relative age voice broke	0.1	0.1	0.4	0.1	-0.1	-0.6	0.3	0.4
Taking other prescription medications	1.0	1.5	4.3	0.7	-1.6	2.1	0.7	0.2
Age when periods started (menarche)	1.2	2.8	4.8	-1.9	1.4	-2.2	-1.2	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	-0.3	-0.4	1.1	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.0	0.1	0.4	0.8	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.4	0.4	0.3	-0.5	0.6
Qualifications: CSEs or equivalent	1.4	1.9	3.9	1.5	-1.2	0.6	2.0	1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.3	-1.2	0.8	0.7	-1.0	0.2
High blood pressure	0.1	0.3	0.8	-0.9	0.2	-0.5	-0.3	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.3	1.2	-1.1	1.5	0.7	0.6
Multivitamins +/- minerals	0.6	0.7	1.7	1.3	-1.0	-0.0	0.9	0.3
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.0	-0.5	1.0	0.5	-0.2
Supplements: Glucosamine	0.4	0.5	1.2	-0.1	0.9	-0.5	-0.4	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	1.4	-0.6	1.1	1.1	0.3
Medication: Atenolol	1.3	1.7	3.4	-1.4	0.8	-0.3	-1.5	-1.8
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.4	0.5	-0.4	0.4	-0.2
Sitting height	0.5	3.4	14.4	-0.2	0.7	3.8	-0.6	1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	0.4	-0.5	0.4	0.8	1.5
High blood pressure (mother)	0.5	0.7	2.2	0.2	0.3	1.5	-0.6	0.9
Body mass index (BMI)	0.7	3.2	12.3	0.7	-1.4	3.5	1.0	-0.1
Impedance of leg (left)	1.2	5.8	10.0	-1.8	2.9	-3.2	-2.7	-0.5
Leg predicted mass (left)	1.1	5.7	22.9	0.6	-1.8	4.8	1.3	0.6
Trunk fat mass	0.6	2.5	10.4	-0.9	0.4	3.2	-0.9	-0.5
Waist circumference	0.4	1.6	8.0	-0.0	-0.1	2.8	0.0	-0.4
Number of incorrect matches in round	3.5	5.8	8.6	-1.9	2.9	-2.6	-2.4	-2.1
Past tobacco smoking	0.4	0.7	1.5	-1.2	0.5	-0.6	-0.4	-1.1
Alcohol usually taken with meals	0.9	1.4	2.5	1.3	-1.1	-0.8	0.8	-1.6
Nervous feelings	0.4	0.8	1.7	0.9	-1.2	0.4	1.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	0.6	-0.5	0.8	0.5	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-0.1	0.2	0.9	-1.2	-0.3
Hair/balding pattern: Pattern 2	4.4	5.6	8.6	2.9	-2.5	2.1	2.4	1.6
Had menopause	0.9	1.2	3.6	-0.6	0.3	-1.3	-0.4	-1.9
Had other major operations	1.1	1.4	2.3	-0.8	0.5	1.2	-1.5	-1.5
Forced vital capacity (FVC)	0.1	0.6	0.8	0.8	-0.9	0.4	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	-0.6	0.6	-0.9	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	4.8	1.2	-1.7	2.2	1.2	0.9
Qualifications: None of the above	0.8	1.6	4.0	-1.0	1.0	0.6	-2.0	-1.4
Financial difficulties in last 2 years	0.6	0.8	2.2	-0.1	0.1	1.2	-0.5	-1.5
Mouth/teeth dental problems	1.8	2.8	5.4	1.5	-1.8	0.4	2.3	1.7
Heart attack	0.3	0.4	2.0	0.1	-0.4	1.4	0.0	-0.1
Allergy	0.6	1.5	2.6	-1.3	1.5	-1.6	-0.9	-0.4
Pain all over the body in last month	0.1	0.1	0.2	-0.1	-0.3	-0.1	-0.2	-0.5
Diabetes (self-reported)	0.8	1.2	2.0	-1.4	1.3	-0.6	-0.8	-1.2
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.6	1.6	-1.4	0.4	1.5	1.2
Medication: Ramipril	2.2	2.8	4.9	-2.1	1.9	-0.5	-2.2	-1.1
Medication: Simvastatin	0.4	0.6	2.6	-0.4	-0.5	1.6	0.1	0.3
Fluid intelligence score	0.6	1.2	2.6	-0.7	1.6	0.2	-1.5	0.8
Illnesses of siblings	2.7	3.7	5.4	2.3	-1.6	1.4	1.9	2.2
Neuroticism score	0.2	0.4	0.7	0.2	-0.6	0.8	0.8	0.5
Weight	1.1	5.3	23.0	0.6	-1.4	4.8	0.9	0.5
Impedance of arm (right)	2.1	9.8	16.4	-3.2	3.6	-4.0	-3.0	-0.7
Arm fat percentage (right)	0.3	1.1	4.8	-0.6	-0.1	2.2	-0.1	-0.6
Trunk fat-free mass	1.7	9.6	29.2	2.0	-2.9	5.4	2.4	0.7
Hip circumference	1.2	5.0	18.9	1.1	-1.7	4.3	1.3	0.3
Time employed in main current job	0.2	0.3	0.6	0.5	-0.8	0.7	0.1	0.0
Alcohol intake versus 10 years previously	1.7	2.6	4.1	2.0	-1.6	1.8	1.5	0.9
Father’s age at death	0.4	0.5	2.2	0.1	0.2	-1.5	0.0	-0.4
Worrier / anxious feelings	0.3	0.6	1.9	0.5	-0.6	-0.2	1.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	4.3	6.9	19.8	1.8	-2.0	4.5	1.5	2.4
Falls in the last year	1.0	1.4	4.1	0.4	-0.5	2.0	0.9	1.3
Hair/balding pattern: Pattern 3	1.2	1.8	3.6	-1.1	1.0	-1.0	-1.5	-1.9
Number of live births	0.2	0.3	0.8	-0.0	-0.4	-0.5	0.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.2	0.9	-1.4	-0.5	1.8	0.9
Pulse rate	1.1	1.9	5.2	-0.5	0.8	-2.3	-0.5	-1.8
Happiness	1.1	1.3	3.4	0.8	-0.9	1.8	0.2	1.3
Noisy workplace	1.6	2.0	5.3	0.9	-1.6	2.3	1.0	-0.7
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.0	-1.2	1.2	-1.8	-1.2	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	4.5	1.3	-0.9	2.1	-1.0	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.6	2.3	0.2	0.0	-0.5	-0.5	-1.5
Asthma	0.1	0.2	0.7	-0.4	-0.1	-0.1	-0.4	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	3.0	1.4	-1.3	1.5	1.7	1.4
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.0	-0.3	0.8	0.5	0.3
Depression (self-reported)	1.7	2.1	4.5	2.1	-1.8	0.5	1.5	-0.0
Medication: Lansoprazole	0.4	0.5	0.9	0.7	-0.6	-0.0	0.8	1.0
Prospective memory result	0.2	0.2	0.3	0.3	-0.5	0.6	0.5	0.1
Lung cancer (father)	0.1	0.1	0.4	-0.3	0.2	-0.6	-0.4	0.1
Illnesses of mother	1.0	1.2	3.6	0.1	-1.5	0.4	1.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	-0.1	-0.4	-0.9	0.3	-0.3
Pulse wave Arterial Stiffness index	3.2	3.8	5.5	2.0	-2.2	2.4	1.8	1.0
Impedance of arm (left)	1.8	8.6	12.4	-3.0	3.5	-3.4	-3.2	-0.3
Arm fat mass (right)	0.6	2.5	11.5	-0.0	-0.8	3.4	0.5	-0.2
Trunk predicted mass	1.7	9.5	28.4	2.1	-2.9	5.3	2.4	0.8
Standing height	0.3	2.6	11.7	-0.3	0.3	3.4	-0.7	0.9
Length of working week for main job	0.8	0.8	1.8	-0.7	1.3	-0.3	-1.3	0.4
Exposure to tobacco smoke at home	0.5	0.6	1.2	-1.1	1.1	-0.2	-0.7	-0.0
Breastfed as a baby	0.1	0.1	0.1	-0.1	-0.2	0.4	-0.2	-0.3
Tense / ‘highly strung’	1.0	1.6	4.1	1.1	-1.5	-0.2	2.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.0	1.1	-1.6	0.3	1.7	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	-0.9	0.9	1.5	-0.4	0.4
Birth weight of first child	1.1	1.9	4.8	-1.2	1.3	2.2	-1.1	0.7
Peak expiratory flow (PEF)	0.1	0.2	0.7	0.2	0.1	-0.4	0.3	0.9
Pulse wave reflection index	1.4	1.7	3.6	1.1	-1.6	0.8	1.9	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.6	-0.7	-0.2	0.3	0.4
Loud music exposure frequency	0.2	0.2	0.7	0.2	0.2	0.3	-0.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.4	0.6	-0.9	0.8	1.2	1.1
Mouth/teeth dental problems: Bleeding gums	2.7	3.6	7.1	-2.7	1.5	-0.3	-2.1	-2.0
Blood clot in the leg (DVT)	0.4	0.5	1.1	0.2	-1.0	0.2	1.0	0.4
Medication: Paracetamol	2.2	3.6	6.8	2.0	-1.9	2.6	1.4	1.3
Headache pain in last month	2.3	4.0	10.5	1.0	-1.3	3.2	0.6	2.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	1.0	-0.6	0.1	0.5	0.2
Glaucoma (self-reported)	0.6	0.7	2.6	-0.1	-0.3	0.1	0.8	1.6
Gout (self-reported)	0.8	1.1	1.7	0.6	-1.2	1.3	0.9	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.3	0.2	-0.8	0.4	1.5	0.4
Medication: Amlodipine	0.2	0.2	0.7	-0.4	0.3	-0.9	-0.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.0	-0.1	-0.9	-0.1	-1.2
Birth weight	0.4	1.0	2.1	-0.5	1.0	1.5	-1.1	0.2
Chronic bronchitis/emphysema (mother)	3.1	3.6	5.6	1.9	-2.2	0.8	2.4	1.7
High blood pressure (siblings)	0.7	1.0	2.5	-1.6	0.8	-0.5	-0.9	-1.0
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.0	-0.3	-0.1	0.1	-0.4
Body fat percentage	0.4	1.6	5.1	-1.1	0.7	2.2	-0.9	-0.6
Leg fat percentage (right)	0.3	1.2	5.5	0.3	-0.4	2.4	0.5	-0.0
Arm fat-free mass (right)	1.7	8.5	27.0	2.0	-2.5	5.2	2.0	0.8
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-1.2	0.8	-0.4	-1.1	-0.6
Comparative body size at age 10	0.1	0.4	2.0	-0.0	-0.2	1.4	-0.2	-0.1
Number of full brothers	0.8	1.0	2.7	-0.4	1.5	-0.1	-1.6	-0.1
Worry too long after embarrassment	0.2	0.3	1.0	0.2	-0.5	1.0	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	6.4	1.7	-1.9	-0.8	2.5	1.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.9	-0.3	0.1	1.4	-0.3	-0.2
Number of children fathered	0.1	0.1	0.3	0.1	0.3	0.6	-0.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.1	0.0
Age at first live birth	1.1	1.9	3.5	1.5	-1.4	-0.7	1.9	1.0
Pulse wave peak to peak time	2.8	3.3	4.8	-1.9	2.2	-2.0	-1.8	-0.8
Health satisfaction	1.8	2.3	6.7	0.9	-1.8	2.6	0.8	-0.0
Shortness of breath walking on level ground	0.3	0.4	1.0	0.4	-0.7	1.0	0.5	-0.2
Qualifications: College or University degree	0.2	0.7	3.0	-0.2	0.4	-1.7	-0.3	-0.6
Eye problems/disorders: None of the above	0.6	0.6	2.0	0.5	-0.3	-0.9	0.4	-1.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.6	0.9	0.9	-0.7	-0.1
Emphysema/chronic bronchitis	0.6	0.6	1.9	-0.3	-0.0	1.4	-0.3	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	3.5	-0.3	0.1	-1.9	0.1	0.2
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.8	-0.1	-0.2	-0.2	-0.3
Medication: Blood pressure	0.4	0.7	1.7	-1.3	0.9	-0.1	-1.0	-0.5
Angina (self-reported)	3.0	3.9	7.2	-2.0	1.8	0.3	-2.7	-2.3
Migraine (self-reported)	2.7	3.3	5.3	2.1	-2.3	1.6	1.6	1.3
Medication: Ibuprofen	1.3	1.5	2.5	0.7	-0.7	1.6	1.5	1.5
Medication: Allopurinol	0.2	0.3	0.7	0.4	-0.8	-0.0	0.8	0.3
Medication: Omeprazole	0.9	1.0	1.8	-1.1	0.8	-0.8	-0.9	-1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.7	0.2	0.3	-0.6	-0.4
Mean time to correctly identify matches	0.1	0.2	0.3	-0.4	0.6	0.5	-0.6	-0.3
Heart disease (mother)	1.0	1.3	3.3	-0.7	1.3	0.4	-1.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.1	-0.6	-0.2	0.5	-0.2
Whole body fat mass	0.6	2.4	11.8	-0.4	-0.2	3.4	-0.2	-0.4
Leg fat mass (right)	0.8	3.1	13.5	0.6	-1.0	3.7	0.8	0.0
Arm predicted mass (right)	1.5	7.6	26.1	1.8	-2.3	5.1	1.7	0.5
Pulse rate, automated reading	1.7	5.3	19.7	-1.4	1.4	-4.4	-0.0	-1.8
Alcohol intake frequency.	0.6	1.5	3.3	-0.8	0.3	1.8	-1.5	-1.1
Comparative height size at age 10	1.0	5.6	22.3	1.1	-0.8	4.7	0.4	1.9
Number of full sisters	0.8	1.0	4.7	0.4	-0.5	2.2	0.1	0.2
Suffer from ‘nerves’	0.6	0.9	1.9	0.8	-1.3	-0.1	1.4	0.3
Overall health rating	0.5	1.0	4.4	-0.9	-0.1	2.1	-0.1	0.0
Chest pain or discomfort	0.4	0.6	1.6	-0.2	-0.0	1.3	-0.9	-0.8
Had major operations	2.4	2.8	6.6	-1.0	1.2	0.9	-2.6	-2.1
Age at last live birth	0.8	1.2	2.3	0.6	-1.2	-0.9	1.5	1.1
Family relationship satisfaction	0.2	0.3	0.6	0.6	-0.6	-0.8	-0.0	0.1
Leg pain on walking	0.6	0.7	1.9	0.7	-1.4	0.6	0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.0	-0.6	0.1	1.7	0.3	1.6
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.2	1.4	-0.9	2.0	0.6	2.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.5	-0.1	0.0	-1.9	1.0	0.3
Medication: Aspirin	0.2	0.3	1.3	0.4	-0.1	1.1	-0.2	0.0
Supplements: Vitamin C	2.1	2.5	4.9	1.9	-1.8	-0.3	2.2	1.0
Knee pain experienced in last month	0.3	0.5	2.2	-0.2	0.1	-0.0	-0.5	-1.5
Hypertension (Self-reported)	0.1	0.2	0.6	-0.8	0.3	-0.0	-0.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.5	0.0	-0.8	-0.7	1.2	0.0
Illnesses of father: Heart disease	1.1	1.5	3.5	-1.0	1.6	0.8	-1.9	0.1
Illnesses of siblings: Diabetes	0.9	1.1	2.4	-0.7	0.3	0.4	-1.5	-1.6
Smoking status: Previous	0.1	0.2	0.7	0.8	-0.0	0.3	0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.7	-0.3	0.4	1.3	-0.5	0.4
Whole body fat-free mass	1.5	8.7	29.6	1.5	-2.6	5.4	2.0	0.8
Leg fat-free mass (right)	1.2	6.3	25.1	0.8	-1.9	5.0	1.2	0.8
Arm fat percentage (left)	0.3	1.3	5.8	-0.5	-0.1	2.4	-0.1	-0.5
Average weekly red wine intake	1.1	1.7	2.9	1.7	-1.6	-0.4	1.7	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	1.1	-0.8	-0.2	1.0	0.9
Mood swings	0.6	1.1	3.0	0.8	-0.5	1.7	0.4	1.1
Loneliness, isolation	0.8	1.2	3.8	0.4	-0.8	1.9	0.7	0.9
Long-standing illness, disability or infirmity	1.0	1.5	7.1	-0.5	-0.1	2.7	-0.5	0.2
Ever had bowel cancer screening	0.3	0.3	1.2	-0.1	0.5	-1.1	-0.1	-0.5
Diabetes diagnosed by doctor	0.9	1.4	2.3	-1.5	1.4	-0.1	-1.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.1	1.0	-1.5	1.0	1.4	0.8
Friendships satisfaction	0.1	0.1	0.2	-0.4	0.2	0.4	-0.3	0.3
Qualifications: nursing, teaching	0.7	1.0	2.5	0.7	-0.9	-1.6	1.1	-0.2
Commuting to job workplace: Walk	0.3	0.3	0.7	0.5	-0.8	0.3	0.8	0.0
Eye problems/disorders: Cataract	0.3	0.3	1.1	-0.0	0.1	0.6	-0.3	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.4	-0.0	-0.0	-1.2	0.2	0.1
Medication for cholesterol	1.0	1.5	2.9	1.3	-0.8	1.7	0.7	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.2	0.2	0.5	-0.2	-0.4
Back pain experienced in last month	0.6	0.9	3.3	-0.1	-0.5	1.1	0.1	-1.8
Mineral and other dietary supplements	0.7	1.0	3.0	-1.7	0.5	-1.1	0.0	-0.6
Breast cancer (self-reported)	0.1	0.1	0.3	-0.1	-0.1	0.2	-0.2	-0.6
Asthma (self-reported)	0.2	0.4	1.0	-0.7	0.2	-0.4	-0.6	-1.0
Osteoporosis (self-reported)	1.8	2.2	3.0	1.5	-1.7	-0.6	1.7	1.7
Osteoarthritis (self-reported)	2.9	3.8	6.7	1.9	-2.0	1.6	2.6	1.5
Medication: Aspirin	0.4	0.5	1.4	0.6	-0.6	1.2	0.3	0.3
Medication: Gliclazide	0.4	0.4	1.5	-0.1	0.2	1.2	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	0.4	-0.6	-1.2	0.1	-1.3
Smoking status: Current	1.1	1.8	3.5	1.7	-0.6	1.9	0.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.3	0.2	-0.7	-2.1	1.3	-1.1
Whole body water mass	1.5	8.4	28.3	1.6	-2.5	5.3	2.0	0.8
Leg predicted mass (right)	1.2	6.2	24.8	0.7	-1.9	5.0	1.1	0.7
Arm fat mass (left)	0.6	2.6	11.7	0.2	-0.9	3.4	0.5	-0.3
Number of self-reported non-cancer illnesses	2.9	5.0	9.6	2.0	-2.2	3.1	1.7	1.9
Average weekly champagne plus white wine intake	0.3	0.4	1.9	-0.1	0.1	-1.4	0.2	-0.5
Miserableness	2.9	5.0	7.0	2.0	-2.1	2.6	2.1	2.3
Guilty feelings	0.8	1.2	1.8	1.2	-1.2	0.9	1.3	0.6
Wears glasses or contact lenses	0.4	0.4	1.1	0.2	0.5	1.1	-0.2	0.7
Ever taken oral contraceptive pill	0.4	0.5	0.9	0.9	-0.1	0.9	0.3	0.9
Hearing aid user	0.8	0.9	2.5	-1.0	0.7	-1.6	-0.4	-0.7
Mother’s age at death	0.8	1.0	3.9	-0.1	-0.2	-2.0	0.8	-0.4
Financial situation satisfaction	0.5	0.6	1.6	0.0	-0.9	0.6	0.5	-1.3
Tinnitus: Yes, now most or all of the time	5.3	6.1	9.0	2.9	-3.0	1.0	2.6	2.4
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.6	0.3	-0.4	-0.3	-0.6
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.7	0.3	0.2	-0.1	0.3
Medication: Blood pressure	0.8	1.4	2.0	-1.4	1.3	-1.0	-1.3	-1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.1	1.3	-1.3	0.8	1.5	0.5
Supplements: Fish oil (including cod liver oil)	2.1	2.8	7.5	2.7	-1.5	1.0	0.8	1.6
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.0	-0.8	0.1	0.8	-0.1
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.0	-0.5	-0.3	0.5	-0.2
Medication: Paracetamol	4.1	6.3	13.8	2.4	-2.3	3.7	1.7	2.0
Medication: Lisinopril	0.8	1.0	2.3	0.7	-0.7	1.5	0.9	0.9
Medication: Atorvastatin	0.6	0.7	1.1	-0.8	0.9	-0.4	-1.0	-1.1
Illnesses of father: High blood pressure	0.2	0.2	0.8	-0.3	-0.1	0.9	0.4	-0.1
Alcohol drinker status: Never	1.2	1.5	4.6	-0.9	0.8	-0.5	-1.1	-2.1
Ever smoked	0.3	0.5	1.2	1.1	-0.4	0.4	0.2	1.0
Basal metabolic rate	1.4	7.9	29.1	1.3	-2.3	5.4	1.7	0.7
Leg fat percentage (left)	0.3	1.0	4.8	0.0	-0.1	2.2	0.0	-0.2
Arm fat-free mass (left)	1.4	7.1	23.4	1.8	-2.4	4.8	1.7	0.4
Number of operations (self-reported)	1.1	1.6	2.8	-1.3	1.1	0.8	-1.7	-1.2
Average weekly beer plus cider intake	0.8	1.2	4.4	0.6	-0.7	0.3	0.9	2.1
Irritability	0.5	0.8	2.1	-0.6	0.9	-0.8	-1.4	-0.5
Risk taking	0.9	1.3	2.7	1.0	-0.9	1.6	0.4	1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.1	1.6	-1.5	-0.1	1.8	0.4
Fractured/broken bones in last 5 years	0.6	0.7	2.6	-1.6	0.8	0.0	-0.5	-0.1
Age started oral contraceptive pill	2.1	2.6	3.3	-1.3	1.6	-1.8	-1.5	-1.8
Diastolic blood pressure, automated reading	0.6	2.0	5.4	0.7	-1.9	-0.7	2.3	0.1
Ever depressed for a whole week	1.2	1.5	2.2	1.1	-1.5	0.9	1.3	1.1
Unable to work because of sickness or disability	1.1	1.4	2.5	-1.6	1.6	0.4	-1.2	-0.8
Commuting to job workplace: Cycle	0.5	0.6	1.1	-0.7	0.4	-1.0	-0.6	-1.0
Myopia	1.3	1.9	4.9	1.7	-0.6	-0.1	1.2	2.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	0.7	-0.0	0.3	0.3	0.6
Cholesterol lowering medication	1.2	1.8	2.5	-1.5	1.3	-0.9	-1.6	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	2.8	-1.7	1.6	-1.0	-1.6	-1.6
Pain experienced in last month	0.4	0.6	0.9	0.8	-0.1	-0.9	0.8	0.9
Supplements: Calcium	1.3	1.4	3.5	1.9	-1.3	-0.5	0.9	0.8
Basal cell carcinoma (self-reported)	2.0	2.4	3.3	0.9	-1.2	1.8	1.8	1.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.6	0.2	-0.3	1.3	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.4	-1.2	0.5	1.3	0.5
Heart disease (siblings)	1.0	1.2	3.2	-0.5	1.4	-0.7	-1.8	-0.3
Alcohol drinker status: Previous	1.6	1.8	5.4	-1.0	1.2	0.5	-2.3	-0.9
Pack years of smoking	0.5	0.8	2.2	-0.4	0.7	1.5	-0.9	-0.4
Impedance of whole body	2.2	11.4	16.4	-3.0	4.0	-4.0	-3.8	-0.7
Leg fat mass (left)	0.7	2.6	11.6	0.4	-0.8	3.4	0.5	-0.2
Arm predicted mass (left)	1.3	6.5	23.1	1.5	-2.1	4.8	1.6	0.6