Hub : Genes

CNOT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.1430 0.050 1.8e-03 0.168 NA 0.153 NA 0.163 2.0e-08 NA 9.4e-08 NA 3.3e-08
2 NTR Blood 0.0566 0.013 1.9e-13 0.061 0.045 0.062 0.028 0.000 5.2e-19 2.7e-14 2.4e-19 1.9e-09 3.4e-01
3 YFS Blood 0.0952 0.017 0.0e+00 0.122 0.106 0.115 0.120 0.119 1.0e-37 1.2e-32 1.2e-35 4.0e-37 9.7e-37
4 TCGA Colon Adenocarcinoma 0.0480 0.026 4.8e-03 0.050 0.036 0.030 NA 0.033 7.4e-04 3.5e-03 7.6e-03 NA 5.3e-03
5 TCGA Rectum Adenocarcinoma 0.2840 0.133 4.9e-03 0.044 0.028 0.047 NA 0.030 3.4e-02 7.4e-02 2.9e-02 NA 6.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 3.8 6.0 9.8 2.4 -2.8 1.9 3.1 1.6
Bipolar Disorder or Schizophrenia 7.2 17.5 25.4 4.8 -5.0 3.0 4.4 3.3
Depressed Affect (Nagel 2018) 1.3 2.7 4.2 1.6 -1.4 2.0 0.8 2.0
Depression (Nagel 2018) 3.3 5.0 6.7 2.4 -2.3 2.1 1.7 2.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 0.5 0.8 -0.0 -1.1 -0.3
Neuroticism (Nagel 2018) 1.3 3.1 4.5 1.9 -2.1 1.7 1.5 1.4
Schizophrenia (2018) 5.5 11.5 17.4 4.0 -4.2 2.3 3.1 3.0
Schizophrenia vs Biploar Disorder 2.9 3.8 6.0 2.0 -2.4 1.3 1.3 2.4
Worry (Nagel 2018) 1.1 2.3 5.1 1.3 -2.2 0.2 2.1 0.4
Alzheimer’s Disease (in mother) 1.8 2.1 4.8 -1.5 2.2 -1.0 -1.6 0.1
Alzheimer’s Disease (in father) 1.5 1.7 3.1 -1.7 1.8 0.4 -1.4 0.2
Alzheimer’s Disease (including proxy) 1.8 2.6 5.8 -1.9 2.4 -0.4 -1.7 0.5
Crohns Disease (2017) 0.6 1.2 1.9 1.1 -1.0 0.7 1.3 1.4
Irritable Bowel Disease (IBD) 1.2 3.0 4.4 1.2 -1.5 2.0 1.6 2.1
Ulcerative Colitis (UC) 1.6 3.1 7.5 0.9 -1.3 2.7 1.2 2.0
Major Depression (MDD) 0.1 0.2 0.2 -0.4 -0.4 -0.5 0.4 -0.2
Reaction Time 0.2 0.3 1.4 0.0 -0.3 1.2 0.3 0.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.9 -1.2 2.2 -0.4 -2.2 -0.2
Breast Cancer 1.4 3.3 5.5 2.3 -2.3 1.9 1.1 1.0
Ovarian Cancer 0.9 1.2 3.3 -0.6 1.3 0.6 -1.8 -0.6
Prostate Cancer 0.1 0.2 0.6 -0.4 0.4 0.2 -0.8 0.2
Age at First Birth 2.2 3.2 6.4 1.6 -2.1 0.5 2.5 1.5
Bipolar Disorder (2011) 1.7 1.7 2.9 0.0 -1.6 1.7 1.7 0.0
Body Mass Index (BMI) (2010) 1.6 2.2 2.9 1.7 -1.7 1.1 1.6 1.3
Coronary Artery Disease (CAD) 4.0 4.7 6.7 -2.2 2.2 -1.2 -2.4 -2.6
Crohns Disease (2012) 0.2 0.3 0.5 0.7 -0.4 -0.2 0.6 0.5
Mean Putamen Volume 1.9 2.2 5.2 1.2 -1.8 2.3 0.6 0.7
Fasting Glucose 0.1 0.2 0.7 0.2 0.3 -0.0 -0.8 -0.2
HbA1C 1.2 1.4 2.1 -0.9 1.1 1.4 -1.0 -1.3
HDL Cholesterol 0.1 0.2 0.4 0.2 -0.5 0.5 0.5 0.6
LDL Cholesterol 0.1 0.1 0.4 -0.5 0.2 0.1 -0.6 -0.2
Lupus 0.2 0.3 0.6 0.3 0.0 0.8 -0.7 -0.5
Neuroticism (2016) 0.5 0.8 1.9 0.2 -0.1 1.3 -0.6 1.4
Primary Biliary Cirrhosis 0.4 0.5 0.9 0.6 -0.9 0.8 0.4 0.8
Rheumatoid Arthritis 0.5 0.7 1.0 -1.0 0.9 -0.9 -0.8 -0.3
Schizophrenia (2014) 5.6 12.3 17.3 3.9 -4.2 2.3 3.6 3.3
Triglycerides 0.2 0.3 1.0 0.5 0.0 0.3 -0.2 1.0
Type 2 Diabetes (T2D) (2012) 1.1 1.3 4.3 -2.1 0.8 -0.5 -0.7 -0.7
Ulcerative Colitis 2.4 3.5 6.8 1.3 -1.6 2.6 1.7 1.8
Blood Eosinophil Count 0.2 1.6 2.8 -1.7 1.3 -0.1 -1.0 -1.6
Blood Platelet Count 1.2 13.9 23.9 -3.6 4.0 -4.9 -2.7 -3.0
Blood Red Count 1.5 14.2 22.6 3.6 -4.8 3.8 4.0 2.4
Blood White Count 0.1 0.5 1.1 -0.9 0.8 -1.0 0.1 -0.1
Heel T-Score 0.0 0.1 0.2 -0.5 0.1 -0.5 -0.3 -0.3
BMI 0.6 3.4 12.4 0.7 -1.6 3.5 1.3 0.1
Height 0.3 6.5 20.6 1.8 -1.3 4.5 0.4 2.7
Waist Hip Ratio (WHR) 1.2 5.5 9.4 -2.4 3.1 -2.1 -2.4 -1.6
Systolic Blood Pressure 1.0 4.9 11.4 1.1 -2.2 3.4 1.6 2.1
Smoking Status 0.7 1.6 2.7 1.6 -0.4 1.6 0.4 1.5
Allergy or Eczema 0.7 1.8 2.8 1.6 -1.4 1.7 0.8 0.9
Cardiovascular Disease 0.2 0.5 1.8 0.4 -1.3 -0.1 0.8 0.2
Hypothyroidism (self reported) 0.4 0.9 2.2 0.3 -0.8 0.9 1.5 0.9
Respiratory disease 0.4 1.0 2.0 0.8 -1.4 1.3 0.6 0.3
Type 2 Diabetes (T2D) (2018) 1.4 2.6 5.9 1.4 -1.6 2.4 1.4 0.7
Lung FEV1/FVC ratio 0.2 1.1 3.0 -0.4 -1.0 -1.1 1.7 0.5
Lung FVC 0.2 1.3 2.1 1.0 -1.1 -1.4 1.4 0.0
Neuroticism 0.4 0.9 2.0 0.7 -1.2 1.4 0.6 0.3
Chronotype (morning person) 0.5 1.2 2.9 1.7 -1.5 0.8 0.7 0.2
Hair Pigment 0.1 4.2 7.1 2.7 -2.2 1.1 2.5 1.2
Tanning 0.0 0.6 1.5 -0.8 1.2 -0.3 -0.7 0.5
Hand grip strength (left) 2.0 5.3 7.3 2.0 -2.5 2.7 2.3 1.9
Number of treatments/medications taken 1.1 2.0 4.1 0.6 -1.9 2.0 1.3 0.4
Average weekly spirits intake 2.5 3.1 6.0 -1.8 1.2 -0.5 -2.2 -2.5
Sensitivity / hurt feelings 0.3 0.6 1.3 -1.2 0.9 0.2 -0.8 -0.1
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.3 1.3 -0.9 1.8 0.8 1.4
Hearing difficulty/problems: Yes 0.1 0.2 0.7 0.4 0.3 -0.2 -0.8 -0.2
Relative age of first facial hair 0.4 0.8 1.6 1.3 -1.2 -0.2 1.0 0.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.5 -1.1 0.9 1.2 -1.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.4 -0.7 -0.8 0.5 -0.6
Ever had hysterectomy (womb removed) 2.1 2.4 5.3 -2.3 1.6 0.7 -1.6 -1.0
Systolic blood pressure, automated reading 0.9 2.5 8.3 0.8 -1.3 2.9 0.7 1.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.6 0.3 0.1 0.2 -0.6 -1.3
Angina 3.3 4.3 8.1 -2.1 1.9 0.3 -2.8 -2.4
Medication for hormone replacement therapy 1.1 1.2 3.0 1.2 -1.4 0.1 1.7 0.0
Vitamin and mineral supplements 0.3 0.5 0.7 -0.9 0.6 0.7 -0.6 0.6
Supplements: Zinc 2.9 3.1 5.4 2.3 -1.5 1.4 1.9 1.6
Medication: Co-codamol 0.4 0.5 1.0 0.8 -0.9 -0.2 1.0 0.1
Medication: Metformin 1.1 1.6 2.8 0.9 -1.0 1.1 1.7 1.4
Diabetes (father) 0.5 0.6 1.3 0.4 -0.9 1.1 0.9 0.5
Diabetes (mother) 1.7 2.2 5.0 -1.0 1.3 1.6 -2.2 0.7
Severe depression (siblings) 4.5 5.0 7.7 2.8 -2.7 1.4 2.7 0.7
Pack years adult smoking proportion 0.6 0.9 3.2 -0.4 0.7 1.8 -0.8 -0.0
Impedance of leg (right) 1.1 5.2 10.7 -1.6 2.7 -3.3 -2.2 -0.4
Leg fat-free mass (left) 1.2 6.2 24.2 0.8 -1.9 4.9 1.4 0.8
Trunk fat percentage 0.6 2.4 4.5 -1.6 1.3 2.1 -1.7 -0.6
Hand grip strength (right) 0.8 2.2 3.9 1.3 -1.4 2.0 1.1 1.5
Townsend deprivation index at recruitment 0.1 0.2 0.4 -0.4 -0.2 0.6 -0.1 -0.6
Current tobacco smoking 1.0 1.7 4.4 1.4 -0.4 2.1 0.3 1.3
Average weekly fortified wine intake 0.4 0.5 1.6 -0.6 0.4 -0.3 -0.5 -1.3
Maternal smoking around birth 0.5 0.8 1.7 1.0 -0.3 1.3 0.4 1.0
Fed-up feelings 0.4 0.7 1.7 0.5 -0.4 1.3 0.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 4.2 2.0 -2.0 1.8 1.7 1.3
Relative age voice broke 0.1 0.1 0.4 0.1 -0.1 -0.6 0.3 0.4
Taking other prescription medications 1.0 1.5 4.3 0.7 -1.6 2.1 0.7 0.2
Age when periods started (menarche) 1.2 2.8 4.8 -1.9 1.4 -2.2 -1.2 -1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.3 -0.3 -0.4 1.1 0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.0 0.1 0.4 0.8 0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 -0.4 0.4 0.3 -0.5 0.6
Qualifications: CSEs or equivalent 1.4 1.9 3.9 1.5 -1.2 0.6 2.0 1.2
Serious illness, injury or assault to yourself 0.6 0.7 1.3 -1.2 0.8 0.7 -1.0 0.2
High blood pressure 0.1 0.3 0.8 -0.9 0.2 -0.5 -0.3 -0.6
Hayfever, allergic rhinitis or eczema 0.6 1.2 2.3 1.2 -1.1 1.5 0.7 0.6
Multivitamins +/- minerals 0.6 0.7 1.7 1.3 -1.0 -0.0 0.9 0.3
Stomach or abdominal pain in last month 0.2 0.3 1.0 -0.0 -0.5 1.0 0.5 -0.2
Supplements: Glucosamine 0.4 0.5 1.2 -0.1 0.9 -0.5 -0.4 -1.1
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.9 1.4 -0.6 1.1 1.1 0.3
Medication: Atenolol 1.3 1.7 3.4 -1.4 0.8 -0.3 -1.5 -1.8
Medication: Levothyroxine sodium 0.1 0.1 0.2 -0.4 0.5 -0.4 0.4 -0.2
Sitting height 0.5 3.4 14.4 -0.2 0.7 3.8 -0.6 1.4
Chronic bronchitis/emphysema (father) 0.6 0.7 2.2 0.4 -0.5 0.4 0.8 1.5
High blood pressure (mother) 0.5 0.7 2.2 0.2 0.3 1.5 -0.6 0.9
Body mass index (BMI) 0.7 3.2 12.3 0.7 -1.4 3.5 1.0 -0.1
Impedance of leg (left) 1.2 5.8 10.0 -1.8 2.9 -3.2 -2.7 -0.5
Leg predicted mass (left) 1.1 5.7 22.9 0.6 -1.8 4.8 1.3 0.6
Trunk fat mass 0.6 2.5 10.4 -0.9 0.4 3.2 -0.9 -0.5
Waist circumference 0.4 1.6 8.0 -0.0 -0.1 2.8 0.0 -0.4
Number of incorrect matches in round 3.5 5.8 8.6 -1.9 2.9 -2.6 -2.4 -2.1
Past tobacco smoking 0.4 0.7 1.5 -1.2 0.5 -0.6 -0.4 -1.1
Alcohol usually taken with meals 0.9 1.4 2.5 1.3 -1.1 -0.8 0.8 -1.6
Nervous feelings 0.4 0.8 1.7 0.9 -1.2 0.4 1.3 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.6 0.6 -0.5 0.8 0.5 0.6
Hearing difficulty/problems with background noise 0.3 0.5 1.5 -0.1 0.2 0.9 -1.2 -0.3
Hair/balding pattern: Pattern 2 4.4 5.6 8.6 2.9 -2.5 2.1 2.4 1.6
Had menopause 0.9 1.2 3.6 -0.6 0.3 -1.3 -0.4 -1.9
Had other major operations 1.1 1.4 2.3 -0.8 0.5 1.2 -1.5 -1.5
Forced vital capacity (FVC) 0.1 0.6 0.8 0.8 -0.9 0.4 0.9 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.8 -0.6 0.6 -0.9 0.6 0.6
Ever unenthusiastic/disinterested for a whole week 1.8 2.3 4.8 1.2 -1.7 2.2 1.2 0.9
Qualifications: None of the above 0.8 1.6 4.0 -1.0 1.0 0.6 -2.0 -1.4
Financial difficulties in last 2 years 0.6 0.8 2.2 -0.1 0.1 1.2 -0.5 -1.5
Mouth/teeth dental problems 1.8 2.8 5.4 1.5 -1.8 0.4 2.3 1.7
Heart attack 0.3 0.4 2.0 0.1 -0.4 1.4 0.0 -0.1
Allergy 0.6 1.5 2.6 -1.3 1.5 -1.6 -0.9 -0.4
Pain all over the body in last month 0.1 0.1 0.2 -0.1 -0.3 -0.1 -0.2 -0.5
Diabetes (self-reported) 0.8 1.2 2.0 -1.4 1.3 -0.6 -0.8 -1.2
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 2.6 1.6 -1.4 0.4 1.5 1.2
Medication: Ramipril 2.2 2.8 4.9 -2.1 1.9 -0.5 -2.2 -1.1
Medication: Simvastatin 0.4 0.6 2.6 -0.4 -0.5 1.6 0.1 0.3
Fluid intelligence score 0.6 1.2 2.6 -0.7 1.6 0.2 -1.5 0.8
Illnesses of siblings 2.7 3.7 5.4 2.3 -1.6 1.4 1.9 2.2
Neuroticism score 0.2 0.4 0.7 0.2 -0.6 0.8 0.8 0.5
Weight 1.1 5.3 23.0 0.6 -1.4 4.8 0.9 0.5
Impedance of arm (right) 2.1 9.8 16.4 -3.2 3.6 -4.0 -3.0 -0.7
Arm fat percentage (right) 0.3 1.1 4.8 -0.6 -0.1 2.2 -0.1 -0.6
Trunk fat-free mass 1.7 9.6 29.2 2.0 -2.9 5.4 2.4 0.7
Hip circumference 1.2 5.0 18.9 1.1 -1.7 4.3 1.3 0.3
Time employed in main current job 0.2 0.3 0.6 0.5 -0.8 0.7 0.1 0.0
Alcohol intake versus 10 years previously 1.7 2.6 4.1 2.0 -1.6 1.8 1.5 0.9
Father’s age at death 0.4 0.5 2.2 0.1 0.2 -1.5 0.0 -0.4
Worrier / anxious feelings 0.3 0.6 1.9 0.5 -0.6 -0.2 1.4 0.6
Frequency of tiredness / lethargy in last 2 weeks 4.3 6.9 19.8 1.8 -2.0 4.5 1.5 2.4
Falls in the last year 1.0 1.4 4.1 0.4 -0.5 2.0 0.9 1.3
Hair/balding pattern: Pattern 3 1.2 1.8 3.6 -1.1 1.0 -1.0 -1.5 -1.9
Number of live births 0.2 0.3 0.8 -0.0 -0.4 -0.5 0.3 -0.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.2 0.9 -1.4 -0.5 1.8 0.9
Pulse rate 1.1 1.9 5.2 -0.5 0.8 -2.3 -0.5 -1.8
Happiness 1.1 1.3 3.4 0.8 -0.9 1.8 0.2 1.3
Noisy workplace 1.6 2.0 5.3 0.9 -1.6 2.3 1.0 -0.7
Qualifications: A levels/AS levels or equivalent 1.1 2.4 4.0 -1.2 1.2 -1.8 -1.2 -2.0
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.7 4.5 1.3 -0.9 2.1 -1.0 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.6 2.3 0.2 0.0 -0.5 -0.5 -1.5
Asthma 0.1 0.2 0.7 -0.4 -0.1 -0.1 -0.4 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 3.0 1.4 -1.3 1.5 1.7 1.4
Medication: Cholesterol lowering 0.1 0.2 0.7 -0.0 -0.3 0.8 0.5 0.3
Depression (self-reported) 1.7 2.1 4.5 2.1 -1.8 0.5 1.5 -0.0
Medication: Lansoprazole 0.4 0.5 0.9 0.7 -0.6 -0.0 0.8 1.0
Prospective memory result 0.2 0.2 0.3 0.3 -0.5 0.6 0.5 0.1
Lung cancer (father) 0.1 0.1 0.4 -0.3 0.2 -0.6 -0.4 0.1
Illnesses of mother 1.0 1.2 3.6 0.1 -1.5 0.4 1.9 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.8 -0.1 -0.4 -0.9 0.3 -0.3
Pulse wave Arterial Stiffness index 3.2 3.8 5.5 2.0 -2.2 2.4 1.8 1.0
Impedance of arm (left) 1.8 8.6 12.4 -3.0 3.5 -3.4 -3.2 -0.3
Arm fat mass (right) 0.6 2.5 11.5 -0.0 -0.8 3.4 0.5 -0.2
Trunk predicted mass 1.7 9.5 28.4 2.1 -2.9 5.3 2.4 0.8
Standing height 0.3 2.6 11.7 -0.3 0.3 3.4 -0.7 0.9
Length of working week for main job 0.8 0.8 1.8 -0.7 1.3 -0.3 -1.3 0.4
Exposure to tobacco smoke at home 0.5 0.6 1.2 -1.1 1.1 -0.2 -0.7 -0.0
Breastfed as a baby 0.1 0.1 0.1 -0.1 -0.2 0.4 -0.2 -0.3
Tense / ‘highly strung’ 1.0 1.6 4.1 1.1 -1.5 -0.2 2.0 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.0 1.1 -1.6 0.3 1.7 0.3
Hair/balding pattern: Pattern 4 0.3 0.8 2.1 -0.9 0.9 1.5 -0.4 0.4
Birth weight of first child 1.1 1.9 4.8 -1.2 1.3 2.2 -1.1 0.7
Peak expiratory flow (PEF) 0.1 0.2 0.7 0.2 0.1 -0.4 0.3 0.9
Pulse wave reflection index 1.4 1.7 3.6 1.1 -1.6 0.8 1.9 0.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.6 -0.7 -0.2 0.3 0.4
Loud music exposure frequency 0.2 0.2 0.7 0.2 0.2 0.3 -0.9 0.6
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.4 0.6 -0.9 0.8 1.2 1.1
Mouth/teeth dental problems: Bleeding gums 2.7 3.6 7.1 -2.7 1.5 -0.3 -2.1 -2.0
Blood clot in the leg (DVT) 0.4 0.5 1.1 0.2 -1.0 0.2 1.0 0.4
Medication: Paracetamol 2.2 3.6 6.8 2.0 -1.9 2.6 1.4 1.3
Headache pain in last month 2.3 4.0 10.5 1.0 -1.3 3.2 0.6 2.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 1.0 -0.6 0.1 0.5 0.2
Glaucoma (self-reported) 0.6 0.7 2.6 -0.1 -0.3 0.1 0.8 1.6
Gout (self-reported) 0.8 1.1 1.7 0.6 -1.2 1.3 0.9 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.3 0.2 -0.8 0.4 1.5 0.4
Medication: Amlodipine 0.2 0.2 0.7 -0.4 0.3 -0.9 -0.2 -0.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.4 -0.0 -0.1 -0.9 -0.1 -1.2
Birth weight 0.4 1.0 2.1 -0.5 1.0 1.5 -1.1 0.2
Chronic bronchitis/emphysema (mother) 3.1 3.6 5.6 1.9 -2.2 0.8 2.4 1.7
High blood pressure (siblings) 0.7 1.0 2.5 -1.6 0.8 -0.5 -0.9 -1.0
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 -0.0 -0.3 -0.1 0.1 -0.4
Body fat percentage 0.4 1.6 5.1 -1.1 0.7 2.2 -0.9 -0.6
Leg fat percentage (right) 0.3 1.2 5.5 0.3 -0.4 2.4 0.5 -0.0
Arm fat-free mass (right) 1.7 8.5 27.0 2.0 -2.5 5.2 2.0 0.8
Exposure to tobacco smoke outside home 0.6 0.8 1.4 -1.2 0.8 -0.4 -1.1 -0.6
Comparative body size at age 10 0.1 0.4 2.0 -0.0 -0.2 1.4 -0.2 -0.1
Number of full brothers 0.8 1.0 2.7 -0.4 1.5 -0.1 -1.6 -0.1
Worry too long after embarrassment 0.2 0.3 1.0 0.2 -0.5 1.0 0.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 6.4 1.7 -1.9 -0.8 2.5 1.8
Wheeze or whistling in the chest in last year 0.2 0.4 1.9 -0.3 0.1 1.4 -0.3 -0.2
Number of children fathered 0.1 0.1 0.3 0.1 0.3 0.6 -0.4 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.5 0.7 -0.1 -0.1 -0.1 0.0
Age at first live birth 1.1 1.9 3.5 1.5 -1.4 -0.7 1.9 1.0
Pulse wave peak to peak time 2.8 3.3 4.8 -1.9 2.2 -2.0 -1.8 -0.8
Health satisfaction 1.8 2.3 6.7 0.9 -1.8 2.6 0.8 -0.0
Shortness of breath walking on level ground 0.3 0.4 1.0 0.4 -0.7 1.0 0.5 -0.2
Qualifications: College or University degree 0.2 0.7 3.0 -0.2 0.4 -1.7 -0.3 -0.6
Eye problems/disorders: None of the above 0.6 0.6 2.0 0.5 -0.3 -0.9 0.4 -1.4
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.6 0.9 0.9 -0.7 -0.1
Emphysema/chronic bronchitis 0.6 0.6 1.9 -0.3 -0.0 1.4 -0.3 -1.0
Medication for pain relief, constipation, heartburn 0.4 0.7 3.5 -0.3 0.1 -1.9 0.1 0.2
Neck or shoulder pain in last month 0.1 0.2 0.6 -0.8 -0.1 -0.2 -0.2 -0.3
Medication: Blood pressure 0.4 0.7 1.7 -1.3 0.9 -0.1 -1.0 -0.5
Angina (self-reported) 3.0 3.9 7.2 -2.0 1.8 0.3 -2.7 -2.3
Migraine (self-reported) 2.7 3.3 5.3 2.1 -2.3 1.6 1.6 1.3
Medication: Ibuprofen 1.3 1.5 2.5 0.7 -0.7 1.6 1.5 1.5
Medication: Allopurinol 0.2 0.3 0.7 0.4 -0.8 -0.0 0.8 0.3
Medication: Omeprazole 0.9 1.0 1.8 -1.1 0.8 -0.8 -0.9 -1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.5 -0.7 0.2 0.3 -0.6 -0.4
Mean time to correctly identify matches 0.1 0.2 0.3 -0.4 0.6 0.5 -0.6 -0.3
Heart disease (mother) 1.0 1.3 3.3 -0.7 1.3 0.4 -1.8 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.4 0.1 -0.6 -0.2 0.5 -0.2
Whole body fat mass 0.6 2.4 11.8 -0.4 -0.2 3.4 -0.2 -0.4
Leg fat mass (right) 0.8 3.1 13.5 0.6 -1.0 3.7 0.8 0.0
Arm predicted mass (right) 1.5 7.6 26.1 1.8 -2.3 5.1 1.7 0.5
Pulse rate, automated reading 1.7 5.3 19.7 -1.4 1.4 -4.4 -0.0 -1.8
Alcohol intake frequency. 0.6 1.5 3.3 -0.8 0.3 1.8 -1.5 -1.1
Comparative height size at age 10 1.0 5.6 22.3 1.1 -0.8 4.7 0.4 1.9
Number of full sisters 0.8 1.0 4.7 0.4 -0.5 2.2 0.1 0.2
Suffer from ‘nerves’ 0.6 0.9 1.9 0.8 -1.3 -0.1 1.4 0.3
Overall health rating 0.5 1.0 4.4 -0.9 -0.1 2.1 -0.1 0.0
Chest pain or discomfort 0.4 0.6 1.6 -0.2 -0.0 1.3 -0.9 -0.8
Had major operations 2.4 2.8 6.6 -1.0 1.2 0.9 -2.6 -2.1
Age at last live birth 0.8 1.2 2.3 0.6 -1.2 -0.9 1.5 1.1
Family relationship satisfaction 0.2 0.3 0.6 0.6 -0.6 -0.8 -0.0 0.1
Leg pain on walking 0.6 0.7 1.9 0.7 -1.4 0.6 0.8 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.0 -0.6 0.1 1.7 0.3 1.6
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.2 1.4 -0.9 2.0 0.6 2.1
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 3.5 -0.1 0.0 -1.9 1.0 0.3
Medication: Aspirin 0.2 0.3 1.3 0.4 -0.1 1.1 -0.2 0.0
Supplements: Vitamin C 2.1 2.5 4.9 1.9 -1.8 -0.3 2.2 1.0
Knee pain experienced in last month 0.3 0.5 2.2 -0.2 0.1 -0.0 -0.5 -1.5
Hypertension (Self-reported) 0.1 0.2 0.6 -0.8 0.3 -0.0 -0.5 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.5 0.0 -0.8 -0.7 1.2 0.0
Illnesses of father: Heart disease 1.1 1.5 3.5 -1.0 1.6 0.8 -1.9 0.1
Illnesses of siblings: Diabetes 0.9 1.1 2.4 -0.7 0.3 0.4 -1.5 -1.6
Smoking status: Previous 0.1 0.2 0.7 0.8 -0.0 0.3 0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.7 -0.3 0.4 1.3 -0.5 0.4
Whole body fat-free mass 1.5 8.7 29.6 1.5 -2.6 5.4 2.0 0.8
Leg fat-free mass (right) 1.2 6.3 25.1 0.8 -1.9 5.0 1.2 0.8
Arm fat percentage (left) 0.3 1.3 5.8 -0.5 -0.1 2.4 -0.1 -0.5
Average weekly red wine intake 1.1 1.7 2.9 1.7 -1.6 -0.4 1.7 0.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.1 1.1 -0.8 -0.2 1.0 0.9
Mood swings 0.6 1.1 3.0 0.8 -0.5 1.7 0.4 1.1
Loneliness, isolation 0.8 1.2 3.8 0.4 -0.8 1.9 0.7 0.9
Long-standing illness, disability or infirmity 1.0 1.5 7.1 -0.5 -0.1 2.7 -0.5 0.2
Ever had bowel cancer screening 0.3 0.3 1.2 -0.1 0.5 -1.1 -0.1 -0.5
Diabetes diagnosed by doctor 0.9 1.4 2.3 -1.5 1.4 -0.1 -1.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.1 1.0 -1.5 1.0 1.4 0.8
Friendships satisfaction 0.1 0.1 0.2 -0.4 0.2 0.4 -0.3 0.3
Qualifications: nursing, teaching 0.7 1.0 2.5 0.7 -0.9 -1.6 1.1 -0.2
Commuting to job workplace: Walk 0.3 0.3 0.7 0.5 -0.8 0.3 0.8 0.0
Eye problems/disorders: Cataract 0.3 0.3 1.1 -0.0 0.1 0.6 -0.3 1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.4 -0.0 -0.0 -1.2 0.2 0.1
Medication for cholesterol 1.0 1.5 2.9 1.3 -0.8 1.7 0.7 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.2 0.2 0.5 -0.2 -0.4
Back pain experienced in last month 0.6 0.9 3.3 -0.1 -0.5 1.1 0.1 -1.8
Mineral and other dietary supplements 0.7 1.0 3.0 -1.7 0.5 -1.1 0.0 -0.6
Breast cancer (self-reported) 0.1 0.1 0.3 -0.1 -0.1 0.2 -0.2 -0.6
Asthma (self-reported) 0.2 0.4 1.0 -0.7 0.2 -0.4 -0.6 -1.0
Osteoporosis (self-reported) 1.8 2.2 3.0 1.5 -1.7 -0.6 1.7 1.7
Osteoarthritis (self-reported) 2.9 3.8 6.7 1.9 -2.0 1.6 2.6 1.5
Medication: Aspirin 0.4 0.5 1.4 0.6 -0.6 1.2 0.3 0.3
Medication: Gliclazide 0.4 0.4 1.5 -0.1 0.2 1.2 -0.6 0.3
Illnesses of father: None of the above (group 1) 0.6 0.7 1.6 0.4 -0.6 -1.2 0.1 -1.3
Smoking status: Current 1.1 1.8 3.5 1.7 -0.6 1.9 0.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 4.3 0.2 -0.7 -2.1 1.3 -1.1
Whole body water mass 1.5 8.4 28.3 1.6 -2.5 5.3 2.0 0.8
Leg predicted mass (right) 1.2 6.2 24.8 0.7 -1.9 5.0 1.1 0.7
Arm fat mass (left) 0.6 2.6 11.7 0.2 -0.9 3.4 0.5 -0.3
Number of self-reported non-cancer illnesses 2.9 5.0 9.6 2.0 -2.2 3.1 1.7 1.9
Average weekly champagne plus white wine intake 0.3 0.4 1.9 -0.1 0.1 -1.4 0.2 -0.5
Miserableness 2.9 5.0 7.0 2.0 -2.1 2.6 2.1 2.3
Guilty feelings 0.8 1.2 1.8 1.2 -1.2 0.9 1.3 0.6
Wears glasses or contact lenses 0.4 0.4 1.1 0.2 0.5 1.1 -0.2 0.7
Ever taken oral contraceptive pill 0.4 0.5 0.9 0.9 -0.1 0.9 0.3 0.9
Hearing aid user 0.8 0.9 2.5 -1.0 0.7 -1.6 -0.4 -0.7
Mother’s age at death 0.8 1.0 3.9 -0.1 -0.2 -2.0 0.8 -0.4
Financial situation satisfaction 0.5 0.6 1.6 0.0 -0.9 0.6 0.5 -1.3
Tinnitus: Yes, now most or all of the time 5.3 6.1 9.0 2.9 -3.0 1.0 2.6 2.4
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.6 0.3 -0.4 -0.3 -0.6
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.7 0.3 0.2 -0.1 0.3
Medication: Blood pressure 0.8 1.4 2.0 -1.4 1.3 -1.0 -1.3 -1.0
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.1 1.3 -1.3 0.8 1.5 0.5
Supplements: Fish oil (including cod liver oil) 2.1 2.8 7.5 2.7 -1.5 1.0 0.8 1.6
High cholesterol (Self-reported) 0.2 0.3 0.7 -0.0 -0.8 0.1 0.8 -0.1
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.0 -0.5 -0.3 0.5 -0.2
Medication: Paracetamol 4.1 6.3 13.8 2.4 -2.3 3.7 1.7 2.0
Medication: Lisinopril 0.8 1.0 2.3 0.7 -0.7 1.5 0.9 0.9
Medication: Atorvastatin 0.6 0.7 1.1 -0.8 0.9 -0.4 -1.0 -1.1
Illnesses of father: High blood pressure 0.2 0.2 0.8 -0.3 -0.1 0.9 0.4 -0.1
Alcohol drinker status: Never 1.2 1.5 4.6 -0.9 0.8 -0.5 -1.1 -2.1
Ever smoked 0.3 0.5 1.2 1.1 -0.4 0.4 0.2 1.0
Basal metabolic rate 1.4 7.9 29.1 1.3 -2.3 5.4 1.7 0.7
Leg fat percentage (left) 0.3 1.0 4.8 0.0 -0.1 2.2 0.0 -0.2
Arm fat-free mass (left) 1.4 7.1 23.4 1.8 -2.4 4.8 1.7 0.4
Number of operations (self-reported) 1.1 1.6 2.8 -1.3 1.1 0.8 -1.7 -1.2
Average weekly beer plus cider intake 0.8 1.2 4.4 0.6 -0.7 0.3 0.9 2.1
Irritability 0.5 0.8 2.1 -0.6 0.9 -0.8 -1.4 -0.5
Risk taking 0.9 1.3 2.7 1.0 -0.9 1.6 0.4 1.4
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.1 1.6 -1.5 -0.1 1.8 0.4
Fractured/broken bones in last 5 years 0.6 0.7 2.6 -1.6 0.8 0.0 -0.5 -0.1
Age started oral contraceptive pill 2.1 2.6 3.3 -1.3 1.6 -1.8 -1.5 -1.8
Diastolic blood pressure, automated reading 0.6 2.0 5.4 0.7 -1.9 -0.7 2.3 0.1
Ever depressed for a whole week 1.2 1.5 2.2 1.1 -1.5 0.9 1.3 1.1
Unable to work because of sickness or disability 1.1 1.4 2.5 -1.6 1.6 0.4 -1.2 -0.8
Commuting to job workplace: Cycle 0.5 0.6 1.1 -0.7 0.4 -1.0 -0.6 -1.0
Myopia 1.3 1.9 4.9 1.7 -0.6 -0.1 1.2 2.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.5 0.7 -0.0 0.3 0.3 0.6
Cholesterol lowering medication 1.2 1.8 2.5 -1.5 1.3 -0.9 -1.6 -1.2
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 2.8 -1.7 1.6 -1.0 -1.6 -1.6
Pain experienced in last month 0.4 0.6 0.9 0.8 -0.1 -0.9 0.8 0.9
Supplements: Calcium 1.3 1.4 3.5 1.9 -1.3 -0.5 0.9 0.8
Basal cell carcinoma (self-reported) 2.0 2.4 3.3 0.9 -1.2 1.8 1.8 1.8
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.6 0.2 -0.3 1.3 -0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.7 0.4 -1.2 0.5 1.3 0.5
Heart disease (siblings) 1.0 1.2 3.2 -0.5 1.4 -0.7 -1.8 -0.3
Alcohol drinker status: Previous 1.6 1.8 5.4 -1.0 1.2 0.5 -2.3 -0.9
Pack years of smoking 0.5 0.8 2.2 -0.4 0.7 1.5 -0.9 -0.4
Impedance of whole body 2.2 11.4 16.4 -3.0 4.0 -4.0 -3.8 -0.7
Leg fat mass (left) 0.7 2.6 11.6 0.4 -0.8 3.4 0.5 -0.2
Arm predicted mass (left) 1.3 6.5 23.1 1.5 -2.1 4.8 1.6 0.6