Hub : Genes

CNTN4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.149 0.034 1.7e-05 0.028 0.044 0.053 0.05 0.046 2.3e-04 4.0e-06 4.7e-07 9e-07 2.3e-06
2 GTEx Adipose Visceral Omentum 0.241 0.084 8.7e-03 0.012 NA 0.023 NA 0.006 7.5e-02 NA 2.1e-02 NA 1.5e-01
3 GTEx Thyroid 0.233 0.053 2.9e-05 0.209 NA 0.194 NA 0.195 6.6e-16 NA 9.0e-15 NA 6.8e-15
4 TCGA Thyroid Carcinoma 0.192 0.040 3.6e-07 0.127 0.094 0.133 NA 0.136 2.5e-12 1.9e-09 7.5e-13 NA 3.7e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 4.9 7.8 16.5 2.8 -0.3 2.6 4.1
Bipolar Disorder or Schizophrenia 10.1 24.6 38.6 6.2 1.7 4.4 6.1
Depressed Affect (Nagel 2018) 4.1 8.6 14.7 -1.9 -1.7 -3.6 -3.8
Depression (Nagel 2018) 0.6 0.9 2.4 -0.9 0.1 -1.6 -0.7
Intelligence (Savage-Jansen 2018) 3.2 9.9 13.5 3.6 1.7 3.1 3.7
Neuroticism (Nagel 2018) 2.2 5.2 9.6 -1.1 -0.7 -3.1 -3.1
Schizophrenia (2018) 8.8 18.2 31.2 5.6 2.5 3.6 4.8
Schizophrenia vs Biploar Disorder 2.5 3.3 6.5 2.6 1.2 1.7 1.5
Worry (Nagel 2018) 0.1 0.1 0.5 -0.1 0.0 -0.7 -0.2
Alzheimer’s Disease (in mother) 0.6 0.7 2.1 1.5 0.5 0.5 0.5
Alzheimer’s Disease (in father) 0.3 0.3 0.9 1.0 0.3 -0.4 -0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 0.9 -0.2 -0.7 -0.5
Crohns Disease (2017) 0.2 0.4 1.0 1.0 -0.1 0.0 0.8
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.6 0.2 -0.1 0.1
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.3 0.6 -0.2 -0.5
Major Depression (MDD) 0.9 1.1 3.0 1.7 0.9 -0.8 0.3
Reaction Time 0.6 1.1 2.3 -1.5 -0.4 -0.5 -1.3
Verbal and Numeric Reasoning (VNR) 2.4 5.7 10.0 3.2 1.9 2.0 2.3
Breast Cancer 0.1 0.1 0.3 0.3 0.2 0.3 0.5
Ovarian Cancer 0.5 0.6 1.7 -0.2 -0.4 -0.8 -1.3
Prostate Cancer 1.2 1.6 3.2 0.3 -0.3 1.8 1.8
Age at First Birth 0.1 0.2 0.8 0.9 -0.0 0.1 0.2
Bipolar Disorder (2011) 0.7 0.7 2.1 0.7 -1.4 0.5 0.0
Body Mass Index (BMI) (2010) 4.3 5.9 8.1 -2.1 -2.4 -2.8 -2.4
Coronary Artery Disease (CAD) 0.4 0.5 0.7 -0.7 0.8 -0.8 -0.2
Crohns Disease (2012) 0.3 0.5 1.7 -0.4 -1.3 -0.2 -0.4
Mean Putamen Volume 0.3 0.4 1.0 0.5 0.1 1.0 0.5
Fasting Glucose 1.9 2.3 7.1 -2.7 -0.3 -0.7 -1.2
HbA1C 3.2 3.6 7.2 -0.1 -2.7 -2.6 -0.5
HDL Cholesterol 0.1 0.2 0.4 -0.0 0.7 -0.6 0.1
LDL Cholesterol 1.2 1.9 6.5 2.6 0.2 0.3 0.9
Lupus 0.9 1.3 3.1 -0.1 -0.4 -1.4 -1.8
Neuroticism (2016) 0.1 0.2 0.3 0.5 -0.3 -0.6 -0.2
Primary Biliary Cirrhosis 0.0 0.1 0.2 0.1 -0.1 0.1 -0.4
Rheumatoid Arthritis 0.9 1.2 3.2 1.8 -0.3 1.2 0.5
Schizophrenia (2014) 7.6 16.8 27.0 5.2 1.1 3.7 5.1
Triglycerides 0.5 0.9 1.3 0.7 -1.2 1.1 0.8
Type 2 Diabetes (T2D) (2012) 0.7 0.9 2.3 0.7 0.4 0.7 1.5
Ulcerative Colitis 0.3 0.4 1.3 -0.1 1.1 0.3 -0.6
Blood Eosinophil Count 0.2 1.9 3.7 0.6 1.9 0.3 1.9
Blood Platelet Count 0.0 0.5 1.4 -0.8 -1.2 0.0 -0.4
Blood Red Count 0.1 0.7 1.6 -1.0 -1.3 0.5 -0.3
Blood White Count 0.2 1.3 2.6 -1.6 -0.0 -1.2 -0.9
Heel T-Score 0.0 0.1 0.3 0.5 0.2 0.5 -0.1
BMI 0.3 1.7 3.1 -0.8 -1.0 -1.8 -1.5
Height 0.4 8.7 11.7 3.4 1.9 3.1 3.1
Waist Hip Ratio (WHR) 0.0 0.1 0.1 0.3 -0.3 -0.2 -0.1
Systolic Blood Pressure 0.5 2.7 4.2 -2.0 -1.6 -0.8 -1.9
Smoking Status 1.3 3.1 5.8 -1.8 0.9 -2.4 -1.5
Allergy or Eczema 0.2 0.5 1.8 -0.1 1.3 -0.5 -0.1
Cardiovascular Disease 1.4 4.7 7.7 -2.1 -0.4 -2.6 -2.8
Hypothyroidism (self reported) 0.4 0.9 1.8 0.1 0.7 -1.1 -1.4
Respiratory disease 0.2 0.3 0.6 0.7 -0.6 -0.1 0.7
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.4 -0.3 -1.1 -1.0 -1.2
Lung FEV1/FVC ratio 0.1 0.5 1.2 1.1 -0.8 0.2 0.4
Lung FVC 0.4 2.0 3.2 -1.2 -1.2 -1.8 -1.4
Neuroticism 1.9 4.5 7.5 -1.5 -1.4 -2.5 -2.7
Chronotype (morning person) 3.6 8.4 14.3 -3.6 -0.1 -2.5 -3.8
Hair Pigment 0.0 0.7 1.0 -1.0 0.7 -1.0 -0.7
Tanning 0.0 0.1 0.2 0.5 -0.1 -0.1 0.2
Hand grip strength (left) 0.3 0.9 1.8 1.2 -1.3 0.1 -0.5
Number of treatments/medications taken 0.8 1.5 2.7 -0.9 -1.7 -1.4 -0.7
Average weekly spirits intake 0.6 0.8 1.2 -0.6 -1.1 -0.8 -1.0
Sensitivity / hurt feelings 1.3 2.3 4.2 -0.8 0.4 -2.0 -2.0
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.4 -0.3 -1.2 -0.7 -0.2
Hearing difficulty/problems: Yes 1.2 1.8 4.7 2.2 -0.6 0.9 1.1
Relative age of first facial hair 1.3 2.7 3.7 1.4 1.8 1.5 1.9
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.7 0.3 -0.2 -1.3 -0.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.3 0.7 0.7 -1.0 -1.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.1 -0.3 0.0 0.9 1.0
Systolic blood pressure, automated reading 0.4 1.1 2.4 -1.5 -1.4 0.0 -0.4
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 3.8 -0.9 -1.6 -2.0 -1.4
Angina 1.1 1.4 2.4 0.9 -1.5 -1.2 -1.0
Medication for hormone replacement therapy 0.8 0.9 1.7 -0.0 1.1 -0.9 -1.3
Vitamin and mineral supplements 0.3 0.3 0.9 0.5 0.1 -0.4 -1.0
Supplements: Zinc 0.8 0.8 3.1 1.8 -0.2 0.3 -0.4
Medication: Co-codamol 0.4 0.5 1.5 1.2 -0.2 0.1 0.5
Medication: Metformin 0.7 1.0 1.7 -0.2 -1.1 -1.3 -0.9
Diabetes (father) 0.5 0.6 0.8 -0.8 0.1 -0.9 -0.9
Diabetes (mother) 0.8 1.0 2.4 1.1 -1.6 -0.4 0.4
Severe depression (siblings) 3.9 4.4 9.5 1.5 1.9 1.5 3.1
Pack years adult smoking proportion 0.9 1.3 1.7 -0.9 -1.2 -1.3 -1.2
Impedance of leg (right) 0.0 0.1 0.2 -0.4 0.4 0.1 0.0
Leg fat-free mass (left) 0.1 0.6 2.1 1.5 0.3 -0.1 0.2
Trunk fat percentage 0.1 0.4 0.6 -0.1 0.8 -0.6 -0.8
Hand grip strength (right) 0.1 0.2 0.4 0.6 -0.7 -0.1 -0.2
Townsend deprivation index at recruitment 2.3 3.3 5.4 1.5 -0.5 2.3 2.3
Current tobacco smoking 2.7 4.5 8.2 -1.9 0.0 -2.9 -2.5
Average weekly fortified wine intake 1.3 1.5 2.7 1.1 -1.2 0.7 1.6
Maternal smoking around birth 0.9 1.3 2.5 -1.0 -1.1 -0.4 -1.6
Fed-up feelings 4.0 7.3 10.4 -1.7 -2.5 -3.2 -3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.5 -1.6 0.3 -0.1 0.2
Relative age voice broke 0.7 1.0 2.2 -0.2 1.4 0.4 1.5
Taking other prescription medications 1.2 1.8 3.2 -0.8 -1.0 -1.8 -1.6
Age when periods started (menarche) 0.9 2.1 5.2 0.6 2.3 1.5 0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.8 0.7 -0.7 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 6.8 0.8 2.6 2.1 1.8
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 -1.2 -0.8 0.1 0.1
Qualifications: CSEs or equivalent 0.6 0.8 1.5 0.9 0.4 -0.8 -1.2
Serious illness, injury or assault to yourself 0.4 0.5 1.7 1.3 -0.3 0.6 0.0
High blood pressure 1.0 2.9 5.3 -1.7 -1.0 -1.5 -2.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 -0.3 0.9 -0.8 -0.6
Multivitamins +/- minerals 1.0 1.3 4.2 -2.1 -0.7 -0.3 -0.7
Stomach or abdominal pain in last month 0.9 1.1 4.0 0.2 -2.0 0.4 0.2
Supplements: Glucosamine 0.1 0.1 0.3 0.2 0.1 -0.5 -0.1
Diverticular disease/diverticulitis (self-reported) 0.5 0.7 1.9 0.1 -0.1 0.8 1.4
Medication: Atenolol 2.2 2.8 6.0 0.1 -0.4 -2.4 -2.2
Medication: Levothyroxine sodium 0.6 1.0 2.5 -0.7 0.1 -1.0 -1.6
Sitting height 0.2 1.3 1.9 1.4 1.4 0.7 0.9
Chronic bronchitis/emphysema (father) 2.0 2.3 6.8 2.6 -0.2 1.0 1.2
High blood pressure (mother) 2.4 3.4 5.6 -1.4 -1.8 -1.6 -2.4
Body mass index (BMI) 0.2 0.9 1.4 -0.4 -0.9 -1.2 -1.1
Impedance of leg (left) 0.0 0.2 0.5 -0.7 0.4 0.3 0.1
Leg predicted mass (left) 0.1 0.6 2.4 1.6 0.2 0.0 0.3
Trunk fat mass 0.1 0.5 0.6 0.3 0.8 -0.8 -0.7
Waist circumference 0.0 0.1 0.2 0.2 -0.2 -0.2 -0.4
Number of incorrect matches in round 1.0 1.6 3.7 -1.7 -0.1 -0.1 -1.9
Past tobacco smoking 0.3 0.5 1.0 -0.0 -0.9 1.0 -0.7
Alcohol usually taken with meals 0.3 0.5 2.1 -1.5 -0.2 -0.1 0.0
Nervous feelings 0.5 0.9 1.9 0.7 1.0 0.4 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.6 -0.6 -1.6 -0.7 -0.3
Hearing difficulty/problems with background noise 1.4 2.2 5.1 2.2 0.3 1.0 1.6
Hair/balding pattern: Pattern 2 1.2 1.5 3.6 0.7 -0.7 1.9 1.2
Had menopause 0.1 0.1 0.2 0.2 -0.4 -0.3 0.4
Had other major operations 0.5 0.6 1.2 0.9 -0.4 -1.1 -0.5
Forced vital capacity (FVC) 0.1 0.4 1.2 1.1 0.0 0.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 6.3 1.0 2.5 1.8 1.7
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 2.6 0.2 -1.6 0.8 0.9
Qualifications: None of the above 0.8 1.8 5.1 -2.3 -0.9 -0.8 -0.8
Financial difficulties in last 2 years 2.0 2.7 6.1 -1.2 -0.1 -1.8 -2.5
Mouth/teeth dental problems 0.6 0.9 1.8 -1.1 -0.7 -0.5 -1.3
Heart attack 1.3 1.6 2.1 -0.9 -1.4 -1.5 -1.2
Allergy 0.3 0.7 1.5 0.5 -1.2 1.0 0.3
Pain all over the body in last month 0.3 0.3 0.9 -0.1 -0.4 0.2 1.0
Diabetes (self-reported) 2.0 3.2 5.0 -1.0 -2.2 -1.9 -1.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 1.3 -1.1 -0.5 -0.2 -0.5
Medication: Ramipril 1.7 2.2 4.4 -1.2 -0.6 -1.6 -2.1
Medication: Simvastatin 3.8 5.5 10.8 -1.8 0.1 -3.3 -2.9
Fluid intelligence score 1.5 3.1 5.6 2.4 1.4 1.8 1.4
Illnesses of siblings 0.6 0.8 1.4 0.5 1.1 0.6 1.2
Neuroticism score 0.6 1.2 2.0 -0.4 -0.9 -1.4 -1.4
Weight 0.1 0.3 0.9 1.0 0.1 -0.4 -0.2
Impedance of arm (right) 0.7 3.3 5.6 1.3 1.5 2.4 1.9
Arm fat percentage (right) 0.0 0.1 0.1 0.4 -0.1 -0.2 -0.4
Trunk fat-free mass 0.1 0.4 1.3 1.2 -0.0 -0.4 0.3
Hip circumference 0.1 0.2 0.5 -0.1 0.0 -0.7 -0.7
Time employed in main current job 3.2 3.7 6.9 -2.5 0.4 -1.2 -2.6
Alcohol intake versus 10 years previously 0.7 1.1 2.4 0.9 -1.5 0.9 0.7
Father’s age at death 0.4 0.6 1.8 -0.5 -0.3 0.4 1.3
Worrier / anxious feelings 1.0 1.8 4.0 0.2 0.3 -1.8 -2.0
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.5 3.1 0.9 -1.8 -0.7 -1.3
Falls in the last year 0.4 0.6 0.8 0.6 0.9 -0.9 -0.6
Hair/balding pattern: Pattern 3 0.9 1.4 4.5 0.2 2.1 -0.7 -0.7
Number of live births 0.6 0.9 2.3 -1.5 -0.2 -0.7 -0.8
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 5.7 2.4 -0.5 1.5 1.7
Pulse rate 0.3 0.4 1.3 1.1 0.4 0.5 0.1
Happiness 0.3 0.3 1.0 0.5 -1.0 0.1 0.4
Noisy workplace 2.7 3.4 4.9 -1.8 -2.2 -1.4 -1.8
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.2 2.0 -0.4 1.8 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.5 1.5 1.6 1.0 0.0
Mouth/teeth dental problems: Dentures 0.5 0.8 3.1 0.2 -1.8 -0.5 0.1
Asthma 0.3 0.5 1.2 0.3 1.1 -0.4 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.2 0.6 -1.5 0.6 -0.1
Medication: Cholesterol lowering 4.1 6.3 10.5 -2.7 -0.1 -2.7 -3.2
Depression (self-reported) 1.6 1.9 4.2 1.7 -0.6 0.6 2.0
Medication: Lansoprazole 1.8 2.1 5.0 -0.8 -2.2 -1.2 -1.0
Prospective memory result 1.0 1.3 2.8 -1.3 -1.7 0.7 0.1
Lung cancer (father) 1.2 1.4 3.2 1.8 0.5 1.1 1.0
Illnesses of mother 0.5 0.7 2.4 0.0 1.6 0.4 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 5.6 2.4 -1.1 1.9 1.9
Pulse wave Arterial Stiffness index 0.3 0.3 1.0 1.0 0.1 -0.2 -0.4
Impedance of arm (left) 0.8 3.9 5.9 1.8 1.7 2.4 1.9
Arm fat mass (right) 0.0 0.2 0.3 0.5 -0.0 -0.5 -0.5
Trunk predicted mass 0.1 0.4 1.4 1.2 0.0 -0.4 0.3
Standing height 0.5 4.5 7.1 2.7 2.2 1.4 2.0
Length of working week for main job 0.9 0.9 1.6 -1.3 -0.9 -0.7 -0.9
Exposure to tobacco smoke at home 0.5 0.5 1.0 0.7 -0.4 1.0 0.7
Breastfed as a baby 0.8 1.0 3.8 -1.9 0.0 -0.6 0.2
Tense / ‘highly strung’ 1.1 1.9 3.3 1.1 0.5 1.6 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.3 1.0 0.8 0.6 1.1
Hair/balding pattern: Pattern 4 1.9 4.7 7.2 -2.4 -0.9 -2.7 -2.2
Birth weight of first child 0.6 1.0 1.8 0.5 0.7 1.3 1.3
Peak expiratory flow (PEF) 0.6 1.4 2.0 1.2 -0.4 1.4 1.4
Pulse wave reflection index 0.3 0.3 0.7 0.8 -0.8 -0.3 0.0
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.8 -0.9 0.7 -0.3 -0.5
Loud music exposure frequency 0.3 0.4 0.6 0.8 -0.0 0.5 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.4 1.5 -0.4 0.2 -0.1
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.6 0.2 1.3 -1.0 -1.1
Blood clot in the leg (DVT) 0.8 1.0 2.1 0.3 0.5 1.2 1.5
Medication: Paracetamol 1.1 1.7 4.2 -0.9 -2.0 -1.3 -0.7
Headache pain in last month 0.5 0.9 3.2 -0.5 -1.8 0.1 -0.2
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 5.8 2.4 0.2 1.6 2.1
Glaucoma (self-reported) 0.7 0.9 1.7 -0.5 1.3 -0.7 -1.0
Gout (self-reported) 0.3 0.4 1.3 0.2 -0.1 1.2 0.5
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 6.0 -0.9 0.6 -2.0 -2.4
Medication: Amlodipine 0.2 0.2 0.5 -0.5 0.5 0.1 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 -0.4 0.2 -1.3 -0.1
Birth weight 1.0 2.2 3.6 1.9 0.9 1.4 1.6
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.6 -0.6 -0.8 0.6 0.2
High blood pressure (siblings) 0.7 1.1 3.2 0.1 -0.8 -0.7 -1.8
Forced vital capacity (FVC), Best measure 0.4 1.4 2.5 1.6 -0.1 0.9 1.5
Body fat percentage 0.1 0.5 1.2 -0.3 0.2 -0.8 -1.1
Leg fat percentage (right) 0.5 1.8 3.6 -0.6 -0.3 -1.7 -1.9
Arm fat-free mass (right) 0.1 0.5 1.3 0.3 -0.4 -1.2 -0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.5 0.7 -0.7 0.2 -0.0
Comparative body size at age 10 1.5 4.0 6.1 -1.5 -2.5 -2.3 -1.5
Number of full brothers 0.5 0.6 1.0 -1.0 -1.0 0.3 -0.4
Worry too long after embarrassment 5.4 9.1 15.1 -2.4 -0.9 -3.9 -3.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.0 -0.5 1.2 -1.4 -1.2
Wheeze or whistling in the chest in last year 0.6 1.0 3.1 -0.8 -0.2 -1.8 -0.4
Number of children fathered 2.5 2.9 7.7 -1.3 -2.8 -1.1 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.9 0.0 0.9 0.9 0.2
Age at first live birth 0.2 0.4 1.1 0.6 0.2 1.0 -0.1
Pulse wave peak to peak time 0.2 0.3 0.6 -0.8 0.2 0.4 0.4
Health satisfaction 0.6 0.8 1.9 0.5 -1.4 -1.0 0.2
Shortness of breath walking on level ground 1.6 1.9 6.7 0.7 -2.6 0.3 0.5
Qualifications: College or University degree 1.4 4.3 6.0 2.3 1.2 2.1 2.4
Eye problems/disorders: None of the above 3.5 4.1 7.5 0.7 1.3 2.6 2.7
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.0 1.5 1.7 0.6 1.4
Emphysema/chronic bronchitis 1.6 1.8 4.7 -0.8 -2.2 -1.4 -0.3
Medication for pain relief, constipation, heartburn 1.3 2.3 8.1 0.2 2.8 0.7 0.7
Neck or shoulder pain in last month 0.3 0.4 1.0 -0.4 0.1 -1.0 -0.6
Medication: Blood pressure 0.5 0.8 1.3 -0.8 1.1 -0.7 -1.0
Angina (self-reported) 1.5 1.9 3.2 0.7 -1.8 -1.5 -1.3
Migraine (self-reported) 2.0 2.5 6.2 -0.7 -2.5 1.8 0.3
Medication: Ibuprofen 0.8 0.9 3.1 -0.6 -1.8 0.2 -0.4
Medication: Allopurinol 0.3 0.5 0.9 -0.8 1.0 0.6 -0.1
Medication: Omeprazole 1.4 1.7 2.6 1.6 0.4 1.1 1.6
Medication: Seretide 50 evohaler 0.9 1.1 2.4 1.6 0.7 -0.2 1.1
Mean time to correctly identify matches 0.6 1.1 1.9 -1.4 -0.1 -0.9 -1.3
Heart disease (mother) 0.2 0.3 1.0 0.3 -1.0 -0.2 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 7.8 2.0 0.3 2.8 2.4
Whole body fat mass 0.1 0.4 0.8 0.2 0.2 -0.8 -0.9
Leg fat mass (right) 0.2 0.9 1.8 -0.1 -0.4 -1.2 -1.3
Arm predicted mass (right) 0.1 0.4 1.1 0.4 -0.1 -1.0 -0.6
Pulse rate, automated reading 0.1 0.3 1.0 1.0 -0.4 0.1 0.3
Alcohol intake frequency. 1.1 2.5 8.7 -1.2 -2.9 0.0 0.3
Comparative height size at age 10 0.1 0.5 0.7 0.8 0.8 -0.5 0.6
Number of full sisters 1.0 1.2 4.0 -0.6 -2.0 0.5 0.0
Suffer from ‘nerves’ 1.1 1.8 3.5 -1.9 -1.5 -0.9 -0.9
Overall health rating 0.9 1.9 4.1 0.2 -1.4 -2.0 -1.2
Chest pain or discomfort 0.8 1.2 2.5 0.2 -1.6 1.0 1.1
Had major operations 0.9 1.1 1.8 1.1 0.0 1.2 1.3
Age at last live birth 0.9 1.2 1.8 1.0 -0.8 1.2 1.3
Family relationship satisfaction 0.3 0.3 1.0 -0.4 -0.4 0.2 1.0
Leg pain on walking 0.5 0.6 1.4 0.5 -1.2 -0.6 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.7 0.9 0.7 0.3 0.6
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.6 1.6 -1.3 -0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.5 0.8 -0.5 0.8 2.1
Medication: Aspirin 0.5 0.7 2.0 0.2 -1.4 -0.4 -0.6
Supplements: Vitamin C 3.5 4.1 8.4 1.7 -0.9 2.1 2.9
Knee pain experienced in last month 0.2 0.3 0.6 0.8 0.4 -0.3 0.5
Hypertension (Self-reported) 1.6 4.4 6.8 -2.3 -0.8 -2.2 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.9 0.0 -0.9 0.3 0.8
Illnesses of father: Heart disease 0.9 1.2 2.2 0.0 -1.3 -1.0 -1.5
Illnesses of siblings: Diabetes 0.8 1.0 2.0 -1.4 -1.2 -0.4 0.6
Smoking status: Previous 0.6 0.8 2.0 0.5 1.0 -0.1 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 0.3 -0.2 -0.7 -0.3
Whole body fat-free mass 0.1 0.4 1.4 1.2 0.1 -0.4 0.2
Leg fat-free mass (right) 0.1 0.5 1.9 1.4 0.4 0.2 0.4
Arm fat percentage (left) 0.0 0.1 0.2 0.5 -0.0 -0.1 -0.4
Average weekly red wine intake 0.3 0.5 1.1 1.1 -0.5 0.4 0.7
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.0 -0.4 -1.7 -0.4 -0.9
Mood swings 0.7 1.2 2.4 0.8 -0.9 -1.0 -1.5
Loneliness, isolation 1.4 2.0 2.7 -0.9 -1.4 -1.6 -1.6
Long-standing illness, disability or infirmity 0.1 0.2 0.6 0.8 -0.3 0.5 0.1
Ever had bowel cancer screening 0.4 0.5 1.2 0.6 0.3 -1.1 -0.5
Diabetes diagnosed by doctor 1.5 2.4 3.6 -0.7 -1.7 -1.9 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.1 -0.4 1.0 1.0 0.6
Friendships satisfaction 0.3 0.3 0.6 -0.0 0.7 0.6 0.8
Qualifications: nursing, teaching 1.4 2.2 6.1 -0.8 -2.5 -1.0 -1.1
Commuting to job workplace: Walk 1.2 1.3 3.2 -0.7 1.1 1.8 0.7
Eye problems/disorders: Cataract 2.2 2.6 4.5 0.9 -1.2 -2.1 -1.9
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 4.4 0.5 0.2 1.8 2.1
Medication for cholesterol 1.5 2.3 4.5 0.9 -0.4 1.9 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.4 -0.2 -0.6 0.2 0.5
Back pain experienced in last month 0.2 0.3 0.6 -0.0 -0.6 0.7 0.6
Mineral and other dietary supplements 0.6 0.8 1.5 1.2 0.2 1.1 0.7
Breast cancer (self-reported) 0.7 0.8 2.2 0.4 0.5 1.5 0.8
Asthma (self-reported) 0.1 0.3 0.7 0.2 0.5 -0.5 0.8
Osteoporosis (self-reported) 1.3 1.6 3.3 -1.8 -0.2 -1.0 -1.5
Osteoarthritis (self-reported) 0.2 0.2 0.7 -0.9 0.3 -0.0 -0.1
Medication: Aspirin 0.6 0.8 2.7 0.4 -1.7 -0.2 -0.5
Medication: Gliclazide 0.1 0.1 0.3 -0.5 -0.1 0.1 0.1
Illnesses of father: None of the above (group 1) 0.8 1.0 1.7 -1.3 -0.6 1.0 0.9
Smoking status: Current 3.2 5.0 8.8 -2.1 -0.0 -3.0 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.9 -0.3 -1.7 -0.6 -0.6
Whole body water mass 0.1 0.4 1.4 1.2 0.0 -0.3 0.3
Leg predicted mass (right) 0.1 0.5 1.7 1.3 0.4 0.1 0.3
Arm fat mass (left) 0.0 0.1 0.2 0.4 0.1 -0.3 -0.3
Number of self-reported non-cancer illnesses 0.5 0.8 2.0 0.2 -1.4 -1.1 -0.4
Average weekly champagne plus white wine intake 0.9 1.3 4.2 0.9 2.0 -0.3 -0.3
Miserableness 1.8 3.0 3.9 -1.0 -1.8 -2.0 -2.0
Guilty feelings 3.4 5.1 11.4 -0.7 -0.8 -2.8 -3.4
Wears glasses or contact lenses 3.0 3.5 9.2 -1.1 -1.5 -3.0 -1.1
Ever taken oral contraceptive pill 1.3 1.4 3.3 -0.6 -0.1 -1.4 -1.8
Hearing aid user 0.3 0.3 0.7 0.4 -0.5 -0.3 -0.8
Mother’s age at death 1.7 2.1 4.1 -1.4 -1.5 -2.0 -0.2
Financial situation satisfaction 1.5 1.8 3.2 -1.1 0.7 -1.8 -1.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.9 1.4 -0.7 -0.1 0.2
Commuting to job workplace: Public transport 0.6 0.7 1.4 -1.2 0.8 -0.2 -0.8
Eye problems/disorders: Glaucoma 0.7 0.9 1.6 -0.0 1.3 -0.7 -1.2
Medication: Blood pressure 0.7 1.3 2.2 -1.2 -0.5 -1.2 -1.5
Pain type(s) experienced in last month: Hip pain 0.8 1.0 4.0 0.2 -2.0 0.0 -0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 0.1 0.1 -1.1 -0.4
High cholesterol (Self-reported) 2.0 3.6 6.6 -1.8 -0.9 -1.9 -2.6
Medication: Bendroflumethiazide 1.2 1.9 5.1 -1.4 -2.3 0.5 -0.6
Medication: Paracetamol 2.8 4.4 5.7 -2.4 -2.0 -2.3 -1.6
Medication: Lisinopril 0.0 0.0 0.0 -0.2 0.2 -0.0 -0.1
Medication: Atorvastatin 0.6 0.8 2.9 0.4 -1.7 -0.1 0.1
Illnesses of father: High blood pressure 0.2 0.2 0.3 0.3 0.3 -0.5 -0.6
Alcohol drinker status: Never 0.1 0.1 0.4 0.6 0.2 0.2 -0.3
Ever smoked 0.2 0.4 1.0 -0.4 0.6 -1.0 0.5
Basal metabolic rate 0.1 0.4 1.4 1.2 0.1 -0.3 0.1
Leg fat percentage (left) 0.4 1.5 3.2 -0.7 -0.3 -1.5 -1.8
Arm fat-free mass (left) 0.1 0.3 0.8 0.4 -0.2 -0.9 -0.5
Number of operations (self-reported) 2.7 4.0 9.7 3.1 -0.3 1.5 2.0
Average weekly beer plus cider intake 0.5 0.7 1.0 1.0 -0.9 -0.6 -0.7
Irritability 1.3 2.2 6.3 2.5 1.2 0.9 0.7
Risk taking 0.2 0.3 0.5 -0.6 0.1 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.3 0.3 0.4 0.8
Fractured/broken bones in last 5 years 0.2 0.3 0.4 0.5 -0.6 0.2 -0.7
Age started oral contraceptive pill 1.1 1.4 2.5 0.7 1.0 1.3 1.6
Diastolic blood pressure, automated reading 0.2 0.7 2.4 -0.2 -1.6 0.6 -0.1
Ever depressed for a whole week 5.2 6.5 10.6 2.7 -0.1 2.8 3.3
Unable to work because of sickness or disability 1.0 1.3 1.7 1.2 -0.8 1.3 1.0
Commuting to job workplace: Cycle 0.6 0.7 2.3 -0.5 1.5 0.4 0.3
Myopia 0.0 0.0 0.0 0.0 -0.1 -0.2 -0.0
Vascular/heart problems diagnosed by doctor 1.2 3.3 6.6 1.5 1.2 1.7 2.6
Cholesterol lowering medication 0.8 1.2 2.4 0.1 -1.4 -1.6 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.5 -0.3 0.4 0.4
Pain experienced in last month 0.8 1.4 3.4 -1.8 0.6 -0.9 -1.0
Supplements: Calcium 0.1 0.1 0.1 0.0 0.4 -0.4 0.0
Basal cell carcinoma (self-reported) 0.9 1.0 2.4 1.2 1.5 -0.5 -0.4
Heart attack/myocardial infarction (self-reported) 1.2 1.6 2.0 -1.0 -1.4 -1.4 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.5 0.2 0.6 0.9 1.2
Heart disease (siblings) 0.4 0.5 1.0 1.0 -0.8 -0.6 -0.3
Alcohol drinker status: Previous 1.9 2.2 5.7 0.8 -1.1 1.2 2.4
Pack years of smoking 0.9 1.3 2.1 -1.1 -0.7 -1.4 -1.2
Impedance of whole body 0.3 1.4 2.4 0.5 1.4 1.5 1.0
Leg fat mass (left) 0.2 0.6 1.2 -0.0 -0.3 -1.1 -1.1
Arm predicted mass (left) 0.1 0.3 0.9 0.1 -0.1 -0.9 -0.5