Hub : Genes

CNTRL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.042 0.017 0.00031 0.056 0.035 0.037 0.033 0.047 2.0e-07 4.1e-05 2.3e-05 6e-05 2.1e-06
2 METSIM Adipose 0.051 0.031 0.00180 0.041 0.021 0.030 0.028 0.032 6.8e-07 2.9e-04 1.9e-05 4e-05 1.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.3 2.1 -0.7 1.5
Bipolar Disorder or Schizophrenia 1.5 3.8 5.7 -1.4 2.4
Depressed Affect (Nagel 2018) 0.3 0.7 1.3 -1.1 0.5
Depression (Nagel 2018) 2.1 3.2 3.4 -1.8 1.7
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.2 -1.5 0.1
Neuroticism (Nagel 2018) 0.6 1.3 2.3 -1.5 0.6
Schizophrenia (2018) 1.2 2.5 3.6 -1.2 1.9
Schizophrenia vs Biploar Disorder 0.5 0.7 0.7 0.9 -0.8
Worry (Nagel 2018) 0.1 0.2 0.2 -0.5 0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 -0.5 1.1
Alzheimer’s Disease (in father) 3.5 3.7 3.8 -1.9 1.9
Alzheimer’s Disease (including proxy) 1.8 2.6 3.8 -1.2 1.9
Crohns Disease (2017) 0.1 0.2 0.5 0.1 0.7
Irritable Bowel Disease (IBD) 0.0 0.0 0.0 0.2 0.1
Ulcerative Colitis (UC) 0.0 0.1 0.2 -0.0 -0.4
Major Depression (MDD) 0.1 0.1 0.3 -0.1 0.5
Reaction Time 4.1 7.8 9.4 3.1 -2.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.1 -1.0 0.0
Breast Cancer 3.6 8.6 11.2 -3.3 2.4
Ovarian Cancer 1.8 2.4 2.7 -1.5 1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 0.5 0.7 0.1
Bipolar Disorder (2011) 1.1 1.1 1.8 -0.6 1.4
Body Mass Index (BMI) (2010) 2.4 3.2 4.5 1.4 -2.1
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.4 -0.4
Crohns Disease (2012) 0.1 0.2 0.4 0.6 0.0
Mean Putamen Volume 0.5 0.5 1.0 -1.0 0.4
Fasting Glucose 1.7 2.1 3.0 -1.1 1.7
HbA1C 0.4 0.4 0.8 -0.9 0.2
HDL Cholesterol 0.1 0.1 0.2 0.5 -0.1
LDL Cholesterol 0.1 0.1 0.2 -0.5 -0.2
Lupus 0.3 0.5 0.9 -0.9 0.2
Neuroticism (2016) 1.2 1.8 2.2 -1.5 1.2
Primary Biliary Cirrhosis 0.4 0.5 0.9 -0.3 1.0
Rheumatoid Arthritis 3.4 4.6 7.1 1.5 -2.7
Schizophrenia (2014) 3.4 7.4 9.4 -2.3 3.1
Triglycerides 0.3 0.6 1.1 0.1 -1.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 0.3 0.3
Ulcerative Colitis 0.2 0.3 0.5 0.4 -0.7
Blood Eosinophil Count 0.2 1.5 1.9 1.1 -1.4
Blood Platelet Count 2.1 24.9 31.0 -4.3 5.6
Blood Red Count 1.5 14.3 16.4 4.0 -3.5
Blood White Count 0.7 5.1 9.5 -0.8 3.1
Heel T-Score 0.9 7.5 10.3 3.2 -2.1
BMI 0.1 0.7 1.4 -0.0 1.2
Height 0.5 9.4 18.1 0.8 -4.2
Waist Hip Ratio (WHR) 1.5 6.8 9.1 2.1 -3.0
Systolic Blood Pressure 1.3 6.7 7.9 2.8 -2.3
Smoking Status 0.9 2.1 2.3 -1.4 1.5
Allergy or Eczema 1.6 4.3 5.7 1.7 -2.4
Cardiovascular Disease 0.5 1.7 2.8 -0.7 1.7
Hypothyroidism (self reported) 2.6 5.9 8.1 1.9 -2.8
Respiratory disease 1.3 3.0 3.0 1.7 -1.7
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.2 0.5 -0.4
Lung FEV1/FVC ratio 0.0 0.0 0.0 0.0 -0.1
Lung FVC 0.2 1.1 1.5 1.2 -0.8
Neuroticism 0.0 0.1 0.2 -0.4 -0.3
Chronotype (morning person) 0.6 1.3 1.6 1.2 -1.0
Hair Pigment 0.4 12.4 13.0 3.6 -3.4
Tanning 0.1 1.1 1.6 -1.3 0.7
Hand grip strength (left) 0.7 1.8 2.9 0.9 -1.7
Number of treatments/medications taken 0.1 0.2 0.3 0.6 0.0
Average weekly spirits intake 0.1 0.1 0.2 -0.3 0.4
Sensitivity / hurt feelings 0.0 0.0 0.1 0.1 0.2
Frequency of depressed mood in last 2 weeks 2.4 3.3 3.8 -1.7 1.9
Hearing difficulty/problems: Yes 0.5 0.8 1.0 0.8 -1.0
Relative age of first facial hair 0.2 0.4 0.8 -0.1 -0.9
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 3.8 2.0 -1.5
Ever used hormone-replacement therapy (HRT) 0.0 0.1 0.1 -0.2 0.2
Ever had hysterectomy (womb removed) 1.9 2.1 2.3 1.4 -1.5
Systolic blood pressure, automated reading 1.9 5.5 6.8 2.6 -2.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.5 -0.1
Angina 0.9 1.2 1.7 1.3 -0.8
Medication for hormone replacement therapy 1.4 1.5 1.8 1.1 -1.3
Vitamin and mineral supplements 0.0 0.1 0.1 0.0 -0.4
Supplements: Zinc 0.2 0.2 0.3 0.6 -0.2
Medication: Co-codamol 0.6 0.7 1.5 -0.1 1.2
Medication: Metformin 1.6 2.2 2.4 -1.4 1.5
Diabetes (father) 4.3 5.3 5.5 2.3 -2.3
Diabetes (mother) 0.2 0.3 0.4 0.6 -0.4
Severe depression (siblings) 0.0 0.0 0.0 0.1 -0.2
Pack years adult smoking proportion 0.8 1.3 2.4 -0.3 1.6
Impedance of leg (right) 2.8 13.8 16.0 3.4 -4.0
Leg fat-free mass (left) 0.4 2.1 2.5 -1.6 1.3
Trunk fat percentage 0.5 2.0 3.5 1.9 -0.7
Hand grip strength (right) 0.9 2.4 2.6 1.4 -1.6
Townsend deprivation index at recruitment 1.0 1.4 1.6 1.1 -1.3
Current tobacco smoking 1.0 1.6 2.1 -1.0 1.5
Average weekly fortified wine intake 1.7 2.0 2.6 1.6 -1.2
Maternal smoking around birth 0.2 0.3 0.5 -0.3 0.7
Fed-up feelings 0.4 0.7 0.8 -0.7 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 3.6 -1.9 1.8
Relative age voice broke 0.5 0.7 1.1 -1.1 0.5
Taking other prescription medications 0.0 0.0 0.1 0.3 0.1
Age when periods started (menarche) 0.0 0.1 0.2 -0.4 0.1
Bilateral oophorectomy (both ovaries removed) 3.2 3.7 5.1 2.3 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.2 5.4 2.3 -1.7
Tinnitus: Yes, but not now, but have in the past 2.0 2.2 2.5 -1.4 1.6
Qualifications: CSEs or equivalent 0.0 0.0 0.0 -0.1 -0.1
Serious illness, injury or assault to yourself 0.8 0.9 1.0 1.0 -0.9
High blood pressure 0.5 1.5 1.7 -1.3 1.1
Hayfever, allergic rhinitis or eczema 2.6 5.7 7.1 2.0 -2.7
Multivitamins +/- minerals 0.0 0.0 0.0 0.0 -0.1
Stomach or abdominal pain in last month 0.1 0.2 0.2 0.4 -0.4
Supplements: Glucosamine 0.2 0.2 0.5 -0.7 -0.1
Diverticular disease/diverticulitis (self-reported) 3.2 3.8 5.4 2.3 -1.5
Medication: Atenolol 1.0 1.3 1.7 -0.9 1.3
Medication: Levothyroxine sodium 1.2 2.0 3.1 1.0 -1.8
Sitting height 0.3 1.8 3.5 -1.9 0.4
Chronic bronchitis/emphysema (father) 0.9 1.0 1.7 -0.6 1.3
High blood pressure (mother) 0.3 0.5 0.6 0.6 -0.8
Body mass index (BMI) 0.1 0.6 1.0 0.4 1.0
Impedance of leg (left) 2.5 12.0 13.3 3.3 -3.7
Leg predicted mass (left) 0.4 2.0 2.5 -1.6 1.2
Trunk fat mass 0.4 1.7 2.7 1.6 -0.9
Waist circumference 0.4 1.4 1.8 1.3 -1.0
Number of incorrect matches in round 0.3 0.5 0.8 0.9 -0.2
Past tobacco smoking 1.0 1.8 1.9 1.4 -1.3
Alcohol usually taken with meals 0.9 1.5 2.5 0.6 -1.6
Nervous feelings 0.3 0.6 0.8 0.6 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.0 0.0 0.0
Hearing difficulty/problems with background noise 0.1 0.2 0.4 0.2 -0.6
Hair/balding pattern: Pattern 2 0.1 0.2 0.3 0.5 -0.3
Had menopause 0.2 0.2 0.3 0.3 -0.5
Had other major operations 0.3 0.4 0.8 0.9 -0.2
Forced vital capacity (FVC) 0.4 1.4 2.0 0.9 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 2.3 1.5 -1.1
Ever unenthusiastic/disinterested for a whole week 0.0 0.1 0.1 0.2 -0.3
Qualifications: None of the above 0.3 0.6 1.2 1.1 0.3
Financial difficulties in last 2 years 1.9 2.6 3.3 1.8 -1.3
Mouth/teeth dental problems 1.8 2.7 3.0 1.7 -1.6
Heart attack 0.3 0.4 0.8 0.9 -0.1
Allergy 2.1 4.9 5.4 -2.1 2.3
Pain all over the body in last month 4.1 4.4 5.0 2.2 -2.0
Diabetes (self-reported) 0.1 0.1 0.2 -0.1 0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.3 1.5 1.0 -1.2
Medication: Ramipril 0.2 0.3 0.6 0.8 -0.1
Medication: Simvastatin 0.0 0.0 0.0 0.2 -0.0
Fluid intelligence score 0.4 0.8 1.6 -1.3 0.0
Illnesses of siblings 0.2 0.2 0.4 -0.6 -0.3
Neuroticism score 0.2 0.5 0.5 -0.7 0.7
Weight 0.0 0.1 0.2 0.4 -0.2
Impedance of arm (right) 0.5 2.2 3.2 1.1 -1.8
Arm fat percentage (right) 0.2 0.7 1.4 1.2 0.2
Trunk fat-free mass 0.1 0.4 0.7 -0.8 0.0
Hip circumference 0.0 0.1 0.1 0.3 0.4
Time employed in main current job 0.6 0.7 1.3 0.4 -1.1
Alcohol intake versus 10 years previously 2.7 4.1 4.2 -2.0 2.0
Father’s age at death 0.6 0.8 1.1 0.7 -1.0
Worrier / anxious feelings 0.1 0.3 0.3 -0.5 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.6 0.8 -0.4
Falls in the last year 0.3 0.5 0.9 -0.3 0.9
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 0.8 0.4
Number of live births 0.4 0.6 1.0 1.0 -0.5
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 2.7 1.3 -1.6
Pulse rate 0.9 1.6 1.7 -1.2 1.3
Happiness 1.7 2.0 3.7 -0.6 1.9
Noisy workplace 1.1 1.4 1.8 1.4 -1.0
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.2 -0.4 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 -0.2 0.2
Mouth/teeth dental problems: Dentures 0.2 0.4 0.6 -0.4 0.8
Asthma 0.3 0.6 0.9 1.0 -0.6
Medication: Ibuprofen (e.g. Nurofen) 2.3 3.0 3.4 -1.8 1.6
Medication: Cholesterol lowering 0.2 0.3 0.4 0.5 0.7
Depression (self-reported) 0.5 0.5 1.1 1.0 -0.1
Medication: Lansoprazole 0.2 0.3 0.5 0.7 -0.2
Prospective memory result 1.9 2.3 2.5 1.6 -1.5
Lung cancer (father) 1.6 1.9 2.0 -1.3 1.4
Illnesses of mother 0.0 0.0 0.1 -0.2 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 4.5 1.6 -2.1
Pulse wave Arterial Stiffness index 1.9 2.3 3.2 -1.8 1.2
Impedance of arm (left) 0.5 2.2 2.9 1.2 -1.7
Arm fat mass (right) 0.1 0.4 0.8 0.9 0.1
Trunk predicted mass 0.1 0.3 0.6 -0.8 -0.0
Standing height 0.3 3.0 6.1 0.1 -2.5
Length of working week for main job 0.1 0.1 0.3 0.2 0.5
Exposure to tobacco smoke at home 0.7 0.8 1.0 -0.7 1.0
Breastfed as a baby 0.2 0.3 0.3 -0.5 -0.5
Tense / ‘highly strung’ 0.0 0.1 0.1 0.0 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.4 1.2 -0.6
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 0.4 -0.7
Birth weight of first child 0.9 1.6 1.7 -1.3 1.2
Peak expiratory flow (PEF) 0.3 0.7 0.8 0.8 -0.9
Pulse wave reflection index 0.4 0.5 0.9 0.5 -0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 0.4 1.0
Loud music exposure frequency 0.2 0.2 0.3 0.5 0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 0.9 -1.0 0.6
Mouth/teeth dental problems: Bleeding gums 3.0 3.9 4.7 -2.2 1.7
Blood clot in the leg (DVT) 0.6 0.7 0.9 0.8 -0.9
Medication: Paracetamol 0.3 0.5 1.0 0.3 1.0
Headache pain in last month 1.0 1.7 1.9 -1.4 1.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.5 -0.7 -0.1
Glaucoma (self-reported) 0.1 0.1 0.1 0.2 0.4
Gout (self-reported) 2.2 3.0 3.3 -1.8 1.6
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 5.4 1.4 -2.3
Medication: Amlodipine 0.5 0.7 1.2 0.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.7 0.5 -0.9
Birth weight 2.0 4.4 4.7 -2.0 2.2
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 0.5 -1.0
High blood pressure (siblings) 0.2 0.3 0.5 0.7 0.0
Forced vital capacity (FVC), Best measure 0.7 2.6 3.7 1.3 -1.9
Body fat percentage 0.6 2.2 4.0 2.0 -0.7
Leg fat percentage (right) 0.9 3.3 5.6 2.4 -1.0
Arm fat-free mass (right) 0.0 0.1 0.2 -0.5 0.2
Exposure to tobacco smoke outside home 0.2 0.2 0.3 0.3 -0.6
Comparative body size at age 10 0.2 0.6 0.9 -0.5 1.0
Number of full brothers 0.3 0.4 0.7 0.9 0.2
Worry too long after embarrassment 0.1 0.2 0.3 -0.5 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 2.1 1.5 -1.2
Wheeze or whistling in the chest in last year 0.2 0.4 0.5 0.7 -0.5
Number of children fathered 0.3 0.3 0.6 -0.8 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 0.7 0.6 -0.8
Age at first live birth 0.3 0.5 0.8 0.4 -0.9
Pulse wave peak to peak time 2.3 2.7 3.5 1.9 -1.4
Health satisfaction 1.4 1.8 3.6 -0.2 1.9
Shortness of breath walking on level ground 0.7 0.8 1.5 0.3 1.2
Qualifications: College or University degree 0.3 0.9 1.1 -1.1 -0.8
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.6 0.3
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.0 0.9 -1.4
Emphysema/chronic bronchitis 1.4 1.6 2.9 1.7 -0.6
Medication for pain relief, constipation, heartburn 1.5 2.5 3.0 1.4 -1.7
Neck or shoulder pain in last month 0.9 1.2 1.9 1.4 -0.7
Medication: Blood pressure 0.3 0.6 0.7 -0.7 0.8
Angina (self-reported) 0.6 0.8 1.1 1.1 -0.7
Migraine (self-reported) 0.6 0.7 0.8 -0.8 0.9
Medication: Ibuprofen 3.9 4.7 6.0 -2.5 1.8
Medication: Allopurinol 1.6 2.2 2.6 -1.3 1.6
Medication: Omeprazole 0.9 1.0 1.1 -1.1 0.9
Medication: Seretide 50 evohaler 2.2 2.5 3.8 -1.1 2.0
Mean time to correctly identify matches 3.4 6.4 7.5 2.7 -2.3
Heart disease (mother) 0.1 0.1 0.2 0.4 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 0.0 -0.0
Whole body fat mass 0.3 1.1 2.0 1.4 -0.5
Leg fat mass (right) 0.4 1.6 2.8 1.7 -0.6
Arm predicted mass (right) 0.0 0.2 0.4 -0.6 0.3
Pulse rate, automated reading 2.4 7.7 8.1 -2.7 2.8
Alcohol intake frequency. 0.1 0.1 0.2 0.5 0.3
Comparative height size at age 10 0.4 2.1 3.5 0.8 -1.9
Number of full sisters 0.6 0.8 1.5 0.3 -1.2
Suffer from ‘nerves’ 1.5 2.4 2.4 -1.5 1.5
Overall health rating 0.4 1.0 1.8 1.3 0.3
Chest pain or discomfort 1.2 1.8 2.9 1.7 -0.8
Had major operations 0.0 0.0 0.1 -0.0 -0.2
Age at last live birth 0.6 0.9 1.2 1.1 -0.8
Family relationship satisfaction 3.3 4.0 7.3 -0.9 2.7
Leg pain on walking 0.4 0.5 0.8 -0.9 0.4
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.6 3.7 1.9 -1.9
Commuting to job workplace: Car/motor vehicle 1.2 1.4 1.7 -1.1 1.3
Illness, injury, bereavement, stress in last 2 years 2.5 3.1 4.3 -2.1 1.4
Medication: Aspirin 0.2 0.3 0.6 -0.2 0.8
Supplements: Vitamin C 1.7 2.0 3.1 -1.0 1.8
Knee pain experienced in last month 0.3 0.5 0.9 0.0 1.0
Hypertension (Self-reported) 0.3 0.8 1.0 -1.0 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.9 5.7 8.6 -1.7 2.9
Illnesses of father: Heart disease 0.0 0.0 0.0 0.2 -0.2
Illnesses of siblings: Diabetes 2.0 2.5 2.6 1.6 -1.5
Smoking status: Previous 0.9 1.4 1.5 -1.1 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 -0.0 -0.6
Whole body fat-free mass 0.1 0.8 1.4 -1.2 0.5
Leg fat-free mass (right) 0.5 2.6 3.0 -1.7 1.5
Arm fat percentage (left) 0.2 0.9 1.8 1.3 0.1
Average weekly red wine intake 0.2 0.2 0.4 -0.6 -0.2
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.6 -0.2 -0.8
Mood swings 0.9 1.7 2.6 -1.6 0.9
Loneliness, isolation 1.0 1.4 1.5 -1.1 1.2
Long-standing illness, disability or infirmity 0.7 1.1 2.2 1.5 -0.0
Ever had bowel cancer screening 0.3 0.3 0.4 -0.6 0.5
Diabetes diagnosed by doctor 0.0 0.1 0.1 0.4 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.7 -0.4 1.3
Friendships satisfaction 1.2 1.5 3.1 0.2 1.7
Qualifications: nursing, teaching 1.2 1.9 3.4 0.7 -1.8
Commuting to job workplace: Walk 0.6 0.6 1.0 1.0 -0.5
Eye problems/disorders: Cataract 0.4 0.4 0.6 -0.8 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.7 -0.8 0.2
Medication for cholesterol 0.1 0.1 0.2 -0.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.3 0.0 -0.6
Back pain experienced in last month 0.5 0.7 0.7 -0.8 0.9
Mineral and other dietary supplements 0.0 0.0 0.0 -0.2 0.2
Breast cancer (self-reported) 1.8 2.2 2.5 1.6 -1.4
Asthma (self-reported) 0.3 0.7 0.7 0.8 -0.8
Osteoporosis (self-reported) 0.6 0.7 1.0 -1.0 0.6
Osteoarthritis (self-reported) 1.3 1.6 2.8 -0.7 1.7
Medication: Aspirin 0.7 1.0 1.4 -0.7 1.2
Medication: Gliclazide 0.9 1.0 1.2 -1.1 1.0
Illnesses of father: None of the above (group 1) 1.9 2.4 2.8 -1.7 1.4
Smoking status: Current 0.8 1.3 1.7 -0.9 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.5 7.5 2.7 -2.4
Whole body water mass 0.1 0.8 1.2 -1.1 0.5
Leg predicted mass (right) 0.5 2.6 3.0 -1.7 1.5
Arm fat mass (left) 0.1 0.6 1.2 1.1 0.0
Number of self-reported non-cancer illnesses 0.3 0.6 0.9 -0.5 0.9
Average weekly champagne plus white wine intake 0.4 0.5 1.0 0.1 -1.0
Miserableness 1.4 2.3 3.0 -1.3 1.7
Guilty feelings 1.7 2.5 2.9 -1.7 1.4
Wears glasses or contact lenses 0.3 0.4 0.4 0.6 -0.6
Ever taken oral contraceptive pill 3.3 3.6 5.0 -2.2 1.5
Hearing aid user 2.6 3.0 3.4 1.9 -1.6
Mother’s age at death 2.6 3.2 3.3 -1.8 1.8
Financial situation satisfaction 0.7 0.8 1.7 1.3 -0.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.8 0.3 -0.9
Commuting to job workplace: Public transport 0.7 0.8 1.0 0.7 -1.0
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.8 -0.0
Medication: Blood pressure 1.1 2.1 2.1 -1.5 1.4
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.6 0.2
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.1 0.3 0.1
High cholesterol (Self-reported) 2.4 4.2 6.4 -1.4 2.5
Medication: Bendroflumethiazide 3.6 5.4 6.4 -2.1 2.5
Medication: Paracetamol 0.2 0.3 0.5 0.4 0.7
Medication: Lisinopril 0.3 0.4 0.7 -0.3 0.9
Medication: Atorvastatin 0.2 0.2 0.4 -0.1 0.6
Illnesses of father: High blood pressure 0.1 0.1 0.1 0.4 0.0
Alcohol drinker status: Never 0.1 0.1 0.1 0.2 0.3
Ever smoked 0.2 0.3 0.3 -0.6 0.5
Basal metabolic rate 0.1 0.4 0.7 -0.8 0.4
Leg fat percentage (left) 0.6 2.1 3.9 2.0 -0.5
Arm fat-free mass (left) 0.0 0.1 0.2 -0.5 0.2
Number of operations (self-reported) 1.7 2.5 3.3 1.8 -1.3
Average weekly beer plus cider intake 1.1 1.6 1.6 1.3 -1.3
Irritability 1.1 1.9 2.6 -1.6 1.1
Risk taking 1.0 1.4 2.6 -0.5 1.6
Ever had prostate specific antigen (PSA) test 2.9 3.3 4.1 -1.6 2.0
Fractured/broken bones in last 5 years 0.1 0.1 0.3 -0.5 0.1
Age started oral contraceptive pill 1.3 1.7 2.3 1.0 -1.5
Diastolic blood pressure, automated reading 0.0 0.1 0.1 -0.2 0.3
Ever depressed for a whole week 0.0 0.0 0.0 0.2 -0.1
Unable to work because of sickness or disability 0.4 0.6 0.6 0.8 0.7
Commuting to job workplace: Cycle 0.0 0.0 0.0 0.2 -0.1
Myopia 0.5 0.7 0.8 0.8 -0.9
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.6 0.7 -0.8
Cholesterol lowering medication 0.1 0.1 0.3 -0.5 0.0
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 1.9 -1.1 1.4
Pain experienced in last month 0.5 0.8 1.2 0.6 -1.1
Supplements: Calcium 0.5 0.6 0.8 0.6 -0.9
Basal cell carcinoma (self-reported) 0.7 0.9 1.3 1.1 0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.9 0.9 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.3 0.3 -0.6
Heart disease (siblings) 0.3 0.3 0.7 -0.1 0.8
Alcohol drinker status: Previous 1.5 1.7 2.7 1.7 -0.8
Pack years of smoking 1.0 1.5 2.8 -0.4 1.7
Impedance of whole body 1.3 6.8 7.9 2.4 -2.8
Leg fat mass (left) 0.3 1.1 2.1 1.4 -0.4
Arm predicted mass (left) 0.0 0.0 0.0 -0.2 -0.1