Hub : Genes

COG1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1470	0.0370	8.9e-06	0.059	0.037	0.069	0.063	0.062	1.1e-07	2.3e-05	9.3e-09	4.0e-08	4.9e-08
2	GTEx	Artery Tibial	0.1746	0.0547	1.2e-03	-0.001	NA	0.000	NA	0.011	4.0e-01	NA	3.2e-01	NA	4.6e-02
3	GTEx	Cells Transformed fibroblasts	0.2800	0.0650	1.2e-04	0.015	NA	0.034	NA	0.029	2.3e-02	NA	1.3e-03	NA	2.7e-03
4	GTEx	Testis	0.2110	0.0590	6.4e-05	0.261	NA	0.217	NA	0.250	6.0e-12	NA	5.2e-10	NA	1.8e-11
5	GTEx	Thyroid	0.1570	0.0400	5.5e-06	0.120	NA	0.090	NA	0.128	1.9e-09	NA	2.3e-07	NA	5.1e-10
6	YFS	Blood	0.1642	0.0211	0.0e+00	0.257	0.165	0.260	0.257	0.256	8.9e-84	1.1e-51	7.8e-85	1.6e-83	3.3e-83
7	TCGA	Prostate Adenocarcinoma	0.0263	0.0168	3.3e-03	0.030	0.014	0.011	NA	0.021	3.4e-04	1.2e-02	2.3e-02	NA	2.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.5	0.2	0.7	0.1	-0.4	0.7	0.3	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.5	0.0	-0.0	-0.6	0.7	0.5	0.5
Depressed Affect (Nagel 2018)	0.6	1.3	1.9	-0.3	-1.4	0.5	1.3	-1.4	-1.4	-1.3
Depression (Nagel 2018)	0.2	0.2	0.5	0.7	0.2	0.1	-0.7	0.7	0.3	0.3
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.3	2.3	0.3	0.9	-0.3	0.6	1.2	1.2
Neuroticism (Nagel 2018)	0.1	0.1	0.3	-0.4	-0.6	-0.1	-0.4	0.1	0.4	0.4
Schizophrenia (2018)	0.1	0.2	0.3	0.6	-0.5	0.2	-0.5	0.4	0.4	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.3	-0.8	0.3	0.7	-0.6	-0.3	-0.2
Worry (Nagel 2018)	1.3	2.7	5.4	1.2	1.2	0.4	-1.9	1.6	2.3	2.2
Alzheimer’s Disease (in mother)	0.5	0.6	2.3	1.5	-0.8	-0.2	0.1	0.2	0.8	0.8
Alzheimer’s Disease (in father)	2.6	2.8	6.5	0.4	0.4	2.6	2.0	-1.6	-1.9	-1.6
Alzheimer’s Disease (including proxy)	0.6	0.9	4.3	2.1	-0.3	1.0	0.2	-0.2	0.3	0.7
Crohns Disease (2017)	1.3	2.9	4.1	-0.1	1.4	-2.0	-1.7	2.0	2.0	1.7
Irritable Bowel Disease (IBD)	0.6	1.5	1.9	-0.2	1.3	-1.4	-1.2	1.4	1.3	1.2
Ulcerative Colitis (UC)	0.1	0.1	0.4	-0.6	0.0	-0.4	0.3	-0.3	-0.3	-0.3
Major Depression (MDD)	0.9	1.1	2.8	0.5	0.8	0.2	-1.7	1.3	1.1	1.0
Reaction Time	1.6	3.1	4.9	-1.5	-1.6	-1.6	1.5	-2.2	-1.8	-2.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.9	2.0	0.6	1.0	-0.4	0.7	1.4	1.4
Breast Cancer	0.2	0.5	1.4	0.5	1.2	-0.5	-0.8	0.6	0.6	0.8
Ovarian Cancer	0.5	0.6	1.8	1.3	0.1	1.0	-0.3	0.7	0.7	0.8
Prostate Cancer	0.1	0.1	0.4	0.0	0.6	-0.3	-0.0	0.0	0.0	0.1
Age at First Birth	0.3	0.5	1.2	-0.9	0.0	-0.6	-0.3	0.0	-0.9	-1.1
Bipolar Disorder (2011)	0.1	0.1	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	-1.4	-0.1	-0.9	0.2	-0.5	-0.1	-0.2
Coronary Artery Disease (CAD)	0.3	0.4	1.4	-0.6	-1.2	-0.8	-0.1	-0.4	-0.3	-0.5
Crohns Disease (2012)	0.3	0.5	1.2	-0.8	0.9	-1.1	-0.3	0.5	0.6	0.4
Mean Putamen Volume	0.6	0.7	1.3	0.8	0.8	-0.1	-0.9	1.1	1.0	0.9
Fasting Glucose	0.3	0.3	0.8	-0.4	-0.9	-0.2	0.6	-0.7	-0.5	-0.5
HbA1C	0.6	0.7	1.6	-0.1	-0.5	0.9	1.0	-1.3	-0.7	-0.6
HDL Cholesterol	0.2	0.3	0.9	-0.2	-0.4	0.4	1.0	-0.7	-0.3	-0.3
LDL Cholesterol	0.1	0.2	0.5	-0.7	-0.6	-0.6	-0.6	0.4	-0.0	0.0
Lupus	0.0	0.0	0.1	-0.3	0.3	0.2	0.3	-0.0	-0.0	-0.0
Neuroticism (2016)	0.8	1.1	2.2	0.7	-0.3	-1.5	-1.1	0.9	1.3	1.2
Primary Biliary Cirrhosis	0.5	0.7	2.2	-0.2	-1.0	1.5	0.8	-0.7	-0.6	-0.5
Rheumatoid Arthritis	1.4	1.9	2.7	-1.6	-0.8	0.1	1.6	-1.6	-1.7	-1.6
Schizophrenia (2014)	0.0	0.1	0.2	-0.2	-0.4	0.2	0.0	-0.1	-0.3	-0.3
Triglycerides	0.2	0.3	0.8	-0.1	-0.2	0.3	0.3	-0.4	-0.9	-0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.5	0.4	-0.2	-0.0	-0.2	-0.1	-0.3
Ulcerative Colitis	0.2	0.2	0.9	-0.3	0.0	1.0	0.1	-0.1	-0.6	-0.6
Blood Eosinophil Count	0.0	0.3	0.6	0.7	0.2	-0.6	0.3	-0.2	0.8	0.7
Blood Platelet Count	0.5	5.8	11.9	-0.5	-2.2	2.0	3.5	-3.2	-2.3	-2.2
Blood Red Count	1.9	18.8	32.6	1.7	4.3	-1.8	-5.7	5.4	4.9	4.6
Blood White Count	0.5	3.9	6.4	-1.9	-1.7	0.2	2.5	-2.5	-2.1	-2.0
Heel T-Score	0.2	1.5	4.8	-0.2	2.2	-1.0	-1.2	1.2	0.9	0.8
BMI	0.1	0.6	1.6	-1.3	-0.0	-1.1	0.0	-0.3	0.6	0.8
Height	0.1	1.8	2.6	1.2	1.4	-0.9	-1.3	1.6	1.3	1.6
Waist Hip Ratio (WHR)	0.1	0.6	2.3	0.7	-1.2	-1.5	-0.2	-0.3	-0.1	-0.3
Systolic Blood Pressure	0.1	0.4	0.9	-0.8	0.1	-0.3	0.7	-0.9	-0.6	-0.7
Smoking Status	0.1	0.3	1.9	-1.4	-0.1	0.6	-0.1	0.3	-0.0	0.1
Allergy or Eczema	0.1	0.4	0.8	0.1	-0.8	0.9	0.4	-0.1	-0.8	-0.7
Cardiovascular Disease	0.2	0.6	1.9	-0.0	-0.7	-1.4	-0.7	0.6	0.8	0.7
Hypothyroidism (self reported)	0.8	1.8	4.6	-2.1	-0.4	-2.0	0.6	-0.8	-1.1	-1.1
Respiratory disease	0.6	1.3	2.0	-1.3	-1.4	0.6	1.0	-0.9	-1.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	1.5	0.1	1.6	0.4	0.0	0.2	0.4
Lung FEV1/FVC ratio	0.1	0.6	2.7	-0.6	-1.6	0.9	-0.3	-0.0	-0.4	-0.5
Lung FVC	0.3	1.7	3.6	1.5	0.1	-0.1	-1.1	1.9	1.4	1.6
Neuroticism	0.4	0.9	1.7	0.8	0.3	-1.3	-0.7	0.5	1.3	1.2
Chronotype (morning person)	0.7	1.7	3.2	1.0	0.9	-1.8	-1.7	1.3	1.1	1.1
Hair Pigment	0.0	0.4	1.4	1.2	0.8	0.4	-0.0	0.4	0.5	0.6
Tanning	0.1	0.7	1.2	-1.0	-0.6	0.1	0.9	-1.0	-1.1	-0.8
Hand grip strength (left)	0.4	1.1	3.2	-1.8	-1.2	0.3	0.5	-0.5	-1.2	-1.0
Number of treatments/medications taken	0.1	0.2	1.5	-0.4	-1.2	0.2	0.2	-0.1	-0.1	-0.0
Average weekly spirits intake	0.6	0.7	1.9	-1.4	-0.4	-0.9	0.7	-1.2	-0.4	-0.5
Sensitivity / hurt feelings	1.5	2.6	10.4	-1.4	0.2	-3.2	-1.4	0.8	1.3	1.1
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.8	-0.3	-1.1	-2.0	-1.2	1.1	0.6	0.5
Hearing difficulty/problems: Yes	1.7	2.7	5.0	-0.5	-1.3	1.1	2.0	-2.2	-1.8	-1.8
Relative age of first facial hair	0.5	0.9	2.7	0.6	-1.6	1.4	1.1	-0.7	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	0.6	-0.0	-0.3	-1.1	1.0	0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	0.1	0.1	-0.7	0.1	-0.3	-0.2	-0.6
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	1.0	-0.2	1.2	0.3	-0.1	0.2	0.2
Systolic blood pressure, automated reading	0.2	0.7	2.3	-0.7	-0.0	1.5	0.8	-0.7	-0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.3	0.5	-0.7	-0.3	0.3	-0.2	-0.2
Angina	0.2	0.3	1.1	-0.1	1.0	0.8	0.2	-0.0	0.2	0.1
Medication for hormone replacement therapy	0.7	0.7	2.0	0.4	-1.4	0.9	0.4	-0.3	-0.9	-1.1
Vitamin and mineral supplements	2.0	2.7	4.8	1.6	2.2	1.4	-1.1	1.6	1.7	1.8
Supplements: Zinc	2.6	2.8	5.4	0.1	1.4	-2.3	-2.0	1.6	1.7	1.8
Medication: Co-codamol	1.3	1.5	2.0	-1.4	-1.4	0.7	1.1	-1.4	-1.2	-1.2
Medication: Metformin	0.4	0.6	2.4	1.6	0.1	0.8	0.0	0.4	0.6	0.7
Diabetes (father)	0.3	0.3	0.7	0.8	-0.6	-0.3	-0.2	-0.1	0.9	0.7
Diabetes (mother)	1.1	1.4	3.4	1.9	-0.1	1.2	-1.2	0.9	1.2	1.1
Severe depression (siblings)	0.1	0.1	0.4	0.2	-0.6	0.2	-0.3	0.3	-0.4	-0.3
Pack years adult smoking proportion	0.2	0.2	0.4	-0.4	0.5	0.1	0.6	-0.5	-0.5	-0.6
Impedance of leg (right)	0.1	0.5	1.3	-0.8	-1.1	-0.1	0.3	-0.5	-0.6	-0.9
Leg fat-free mass (left)	0.1	0.5	2.0	-0.0	1.4	-0.3	-0.7	0.6	0.5	0.8
Trunk fat percentage	0.0	0.2	0.7	-0.9	-0.3	-0.3	-0.4	0.4	0.3	0.3
Hand grip strength (right)	0.2	0.6	2.1	-1.5	-0.5	0.6	0.5	-0.4	-0.9	-0.8
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.4	0.4	0.4	-0.0	-0.0	-0.2	-0.4
Current tobacco smoking	0.5	0.9	2.9	-0.7	1.7	0.2	-0.9	1.1	0.6	0.7
Average weekly fortified wine intake	0.5	0.6	1.0	-0.7	-1.0	0.6	0.9	-0.8	-0.7	-0.6
Maternal smoking around birth	0.1	0.2	0.9	-0.1	-0.4	-0.9	-0.5	-0.0	0.3	0.1
Fed-up feelings	0.5	1.0	3.4	0.1	-1.8	-1.2	0.8	-0.9	-0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.7	0.1	0.5	-2.2	-1.3	1.1	0.3	0.3
Relative age voice broke	1.0	1.5	5.7	1.4	-2.4	0.8	1.0	-0.7	0.5	0.6
Taking other prescription medications	0.2	0.4	1.7	-1.3	0.0	-0.6	0.3	-0.3	-0.3	-0.4
Age when periods started (menarche)	0.1	0.1	0.7	0.2	0.8	0.3	0.4	0.1	-0.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.5	-0.5	0.8	0.7	-0.4	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.5	-0.8	-1.2	-0.1	0.7	-1.1	-1.6	-1.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.0	0.9	-0.8	-1.4	-0.7	0.7	1.0	0.9
Qualifications: CSEs or equivalent	2.7	3.6	6.5	-2.5	-0.8	-1.2	1.5	-2.0	-2.2	-2.4
Serious illness, injury or assault to yourself	1.1	1.3	3.4	0.4	-0.0	-0.6	-1.7	1.8	1.1	1.0
High blood pressure	0.1	0.3	0.9	-0.6	-0.0	-1.0	-0.6	0.3	-0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.1	-0.2	-0.2	-0.1	-1.0	1.1	0.2	0.2
Multivitamins +/- minerals	2.2	2.8	7.5	-1.1	-2.7	-1.2	1.3	-1.6	-1.7	-1.5
Stomach or abdominal pain in last month	0.3	0.3	1.4	-0.4	-0.8	-1.2	-0.2	-0.1	0.2	0.1
Supplements: Glucosamine	0.9	1.2	1.8	0.4	-1.1	-1.4	-1.0	1.1	1.3	1.3
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	3.7	1.7	1.7	0.1	-1.7	1.9	1.8	1.9
Medication: Atenolol	0.4	0.5	2.3	-0.6	0.6	-1.5	-0.1	-0.1	-0.2	-0.3
Medication: Levothyroxine sodium	0.4	0.6	1.5	-0.7	-0.5	-1.2	-1.0	0.8	0.5	0.5
Sitting height	0.1	0.7	1.6	-0.6	0.8	-0.8	-1.3	1.1	0.4	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	1.5	-0.2	0.5	-1.2	-0.3	0.1	0.3	0.2
High blood pressure (mother)	0.1	0.2	0.5	0.3	-0.2	0.6	-0.7	0.5	-0.2	-0.1
Body mass index (BMI)	0.1	0.5	1.8	-1.4	0.6	-0.8	-0.4	0.3	0.2	0.3
Impedance of leg (left)	0.1	0.7	1.5	-1.2	-1.2	-0.1	0.3	-0.4	-0.7	-1.0
Leg predicted mass (left)	0.1	0.5	2.0	0.1	1.4	-0.1	-0.7	0.6	0.5	0.8
Trunk fat mass	0.1	0.4	0.8	-0.9	0.1	-0.5	-0.7	0.6	0.6	0.7
Waist circumference	0.2	0.6	1.4	-0.6	0.3	-1.2	-1.0	0.7	0.6	0.7
Number of incorrect matches in round	0.7	1.2	2.7	-1.7	0.2	0.1	0.6	-0.9	-1.5	-1.5
Past tobacco smoking	1.3	2.4	6.3	1.1	2.5	-0.2	-1.5	1.6	1.5	1.5
Alcohol usually taken with meals	0.2	0.3	0.6	-0.5	-0.3	0.3	0.7	-0.4	-0.7	-0.8
Nervous feelings	1.5	2.9	8.4	0.1	1.2	-2.9	-1.6	1.2	1.9	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.6	1.1	1.2	-1.2	-1.4	1.6	1.6	1.6
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.4	-1.3	-0.2	0.7	-1.0	-0.7	-0.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	0.8	-1.1	0.8	0.9	-0.8	-0.3	-0.1
Had menopause	0.2	0.3	0.7	-0.8	0.1	-0.3	0.4	-0.5	-0.5	-0.6
Had other major operations	1.5	1.8	3.5	0.9	-0.1	0.1	-1.4	1.7	1.9	1.9
Forced vital capacity (FVC)	0.4	1.4	3.2	0.6	-0.3	-0.6	-1.2	1.8	1.3	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.9	-1.4	-1.1	-1.1	0.6	-0.9	-1.7	-1.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.9	0.8	-1.2	0.3	1.4	-0.6	-0.7	-0.6
Qualifications: None of the above	0.5	1.0	5.1	0.3	1.4	2.3	-0.0	0.1	-0.3	-0.2
Financial difficulties in last 2 years	1.4	1.9	3.3	0.7	0.9	0.8	-1.4	1.7	1.7	1.8
Mouth/teeth dental problems	1.0	1.5	9.2	-0.4	3.0	0.2	-0.4	0.7	0.2	0.3
Heart attack	0.2	0.2	0.6	-0.2	-0.5	-0.1	0.8	-0.6	-0.3	-0.2
Allergy	0.3	0.6	1.9	1.4	0.1	0.2	1.1	-1.1	-0.2	-0.1
Pain all over the body in last month	0.4	0.5	1.4	1.2	-0.6	1.1	0.5	-0.1	0.1	0.1
Diabetes (self-reported)	0.3	0.4	1.4	0.5	1.2	1.1	-0.0	0.4	-0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.8	-0.7	-0.9	-0.7	-1.3	1.3	0.9	0.8
Medication: Ramipril	0.2	0.2	0.7	0.8	0.3	0.8	0.1	-0.0	0.2	0.3
Medication: Simvastatin	0.7	1.0	1.9	-0.1	-0.1	1.4	1.3	-1.1	-1.2	-1.0
Fluid intelligence score	0.9	1.8	2.9	1.6	1.1	1.1	-1.0	1.2	1.6	1.7
Illnesses of siblings	0.7	1.0	2.1	1.5	-0.5	0.8	-0.8	1.2	1.0	1.1
Neuroticism score	0.7	1.5	8.6	-0.1	0.0	-2.9	-0.6	0.2	1.1	0.9
Weight	0.1	0.7	1.5	-1.2	0.9	-0.8	-0.9	0.7	0.4	0.6
Impedance of arm (right)	0.1	0.3	1.6	0.1	-1.3	-0.3	0.2	-0.2	-0.3	-0.6
Arm fat percentage (right)	0.1	0.4	1.2	-1.1	0.2	-0.7	-0.8	0.6	0.5	0.4
Trunk fat-free mass	0.1	0.5	1.8	-0.7	1.3	-0.4	-0.8	0.6	0.2	0.5
Hip circumference	0.1	0.4	2.0	-1.4	0.3	-0.6	-0.2	0.1	-0.0	0.2
Time employed in main current job	1.0	1.2	2.3	0.1	-0.9	1.4	1.5	-1.1	-1.0	-0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.4	0.3	0.2	-0.6	0.0	0.1	0.4	0.5
Father’s age at death	1.7	2.3	3.3	1.6	1.8	-0.4	-1.8	1.8	1.4	1.5
Worrier / anxious feelings	0.7	1.2	5.9	0.2	0.5	-2.4	-0.7	0.4	1.1	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.2	-0.7	-0.4	-1.5	-0.7	0.6	0.7	0.7
Falls in the last year	2.1	2.8	9.6	-1.5	-0.1	-3.1	-1.8	1.4	1.2	1.0
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	0.6	-1.3	0.9	0.5	-0.5	-0.1	-0.0
Number of live births	0.2	0.3	1.4	-0.4	0.4	1.2	0.3	-0.2	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.5	-0.0	-0.3	-1.0	-1.5	1.9	1.3	1.4
Pulse rate	0.6	1.0	2.2	-1.0	-0.0	-0.0	0.9	-1.2	-1.5	-1.3
Happiness	1.6	1.9	7.7	2.8	-0.0	0.9	-0.0	0.8	1.3	1.6
Noisy workplace	4.3	5.3	7.0	-2.4	-2.5	-0.8	2.3	-2.4	-2.5	-2.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.3	1.5	0.5	1.4	-0.3	0.5	0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.6	1.9	-0.0	1.3	-1.0	1.3	1.0	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	2.7	0.4	-1.6	0.6	0.0	-0.2	-0.5	-0.5
Asthma	0.3	0.5	1.4	-1.1	-1.2	-0.9	-0.2	0.1	-0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	0.3	-0.8	-1.2	-0.8	0.7	0.8	0.9
Medication: Cholesterol lowering	0.2	0.2	0.9	-0.1	0.6	0.9	-0.1	0.1	-0.5	-0.3
Depression (self-reported)	0.8	0.9	1.7	0.0	-1.1	0.2	1.3	-1.1	-1.1	-1.1
Medication: Lansoprazole	0.6	0.6	2.9	-0.9	0.0	-1.7	0.5	-0.4	-0.4	-0.5
Prospective memory result	1.3	1.6	3.3	-1.5	-1.2	-1.8	0.7	-0.8	-1.2	-1.4
Lung cancer (father)	0.4	0.5	1.1	-1.1	0.0	-1.1	0.6	-0.3	-0.7	-0.5
Illnesses of mother	0.3	0.4	1.4	-0.8	1.2	-0.7	-0.2	0.5	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.7	-0.9	-0.7	-1.3	-0.9	1.2	0.5	0.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.0	0.8	0.2	-0.0	-1.2	1.4	0.9	0.9
Impedance of arm (left)	0.1	0.3	1.1	1.0	-0.9	0.0	-0.1	0.4	0.5	0.2
Arm fat mass (right)	0.2	0.7	1.5	-1.2	0.6	-0.9	-0.9	0.8	0.6	0.7
Trunk predicted mass	0.1	0.5	1.7	-0.6	1.3	-0.4	-0.8	0.5	0.2	0.5
Standing height	0.0	0.4	1.0	-0.0	0.8	-0.2	-1.0	0.9	0.4	0.7
Length of working week for main job	1.0	1.1	2.2	1.5	0.8	0.3	-1.3	1.3	0.9	0.9
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.1	-0.9	0.3	0.7	-0.8	-0.5	-0.6
Breastfed as a baby	0.5	0.7	2.7	-0.8	1.0	1.6	0.6	-0.3	-0.1	-0.0
Tense / ‘highly strung’	1.2	1.9	5.3	0.3	1.3	-2.3	-1.1	1.0	1.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.4	-0.4	-1.2	-0.4	0.3	0.8	0.7
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	0.8	1.0	0.1	-0.1	0.5	0.3	0.5
Birth weight of first child	0.5	1.0	6.0	0.5	-0.4	2.5	0.5	-0.3	-0.3	-0.1
Peak expiratory flow (PEF)	0.9	2.1	5.4	0.4	-0.2	-0.0	-1.9	2.3	1.6	1.8
Pulse wave reflection index	1.5	1.8	3.5	0.9	0.6	-0.8	-1.5	1.9	1.6	1.7
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.0	1.7	-0.3	-0.6	-0.6	0.8	0.9	1.0
Loud music exposure frequency	2.4	2.6	5.7	-1.1	-0.6	1.0	1.6	-1.5	-2.3	-2.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.3	-0.0	-0.2	-0.2	0.3	-0.1	0.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	7.3	0.5	-2.7	-0.1	1.2	-1.1	-0.2	-0.1
Blood clot in the leg (DVT)	0.4	0.6	1.6	-1.2	1.3	-0.0	0.4	-0.5	-0.5	-0.4
Medication: Paracetamol	0.3	0.5	1.1	-0.4	-0.5	-0.1	-0.9	1.1	0.6	0.7
Headache pain in last month	0.1	0.2	0.8	-0.9	0.1	-0.7	0.1	-0.0	-0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	-0.1	-0.3	0.6	1.0	-0.8	-0.5	-0.6
Glaucoma (self-reported)	0.1	0.1	0.1	-0.1	-0.3	0.4	-0.2	-0.0	0.4	0.4
Gout (self-reported)	3.1	4.3	7.2	-2.7	-1.9	-0.1	2.2	-1.9	-2.3	-2.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.3	-0.9	0.2	-1.8	-0.8	0.6	0.2	0.2
Medication: Amlodipine	0.8	1.1	3.4	-0.8	-1.8	-0.1	0.5	-0.7	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-1.1	-1.3	-0.6	0.8	-0.7	-0.4	-0.6
Birth weight	0.4	0.8	2.5	0.8	0.1	1.6	1.0	-0.7	-0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.5	0.7	-0.5	-0.4	0.6	0.5	0.7
High blood pressure (siblings)	0.7	1.0	1.7	-1.0	-0.5	-0.4	0.8	-1.2	-1.3	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.6	1.2	-0.5	-0.7	-0.9	-0.6	1.1	0.5	0.7
Body fat percentage	0.1	0.3	1.2	-1.1	0.1	-0.4	-0.6	0.5	0.4	0.4
Leg fat percentage (right)	0.1	0.3	1.3	-1.1	0.1	-0.3	-0.5	0.3	0.4	0.4
Arm fat-free mass (right)	0.1	0.6	1.9	-0.7	1.4	-0.3	-0.9	0.7	0.4	0.7
Exposure to tobacco smoke outside home	0.5	0.7	1.3	-0.8	-0.6	-1.0	0.6	-1.2	-0.8	-1.0
Comparative body size at age 10	0.4	1.0	2.1	-0.7	-0.7	0.1	1.3	-1.4	-1.0	-1.0
Number of full brothers	0.2	0.3	0.6	-0.2	0.8	0.7	0.3	-0.2	-0.4	-0.5
Worry too long after embarrassment	2.1	3.5	6.8	1.2	0.1	-2.6	-1.9	1.6	2.3	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.7	-0.8	-0.8	-0.4	0.3	0.1	0.1
Wheeze or whistling in the chest in last year	0.5	0.8	2.0	-1.1	-0.4	-0.4	0.3	-0.3	-1.4	-1.4
Number of children fathered	0.3	0.3	1.1	-0.5	1.0	-1.0	0.0	0.2	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.3	0.5	-1.5	0.5	-0.4	0.4	0.7	0.7
Age at first live birth	0.1	0.1	0.7	0.3	-0.1	0.8	-0.0	0.1	-0.1	0.1
Pulse wave peak to peak time	0.6	0.7	1.7	-0.8	-0.0	0.1	1.2	-1.3	-0.8	-0.9
Health satisfaction	0.6	0.8	1.5	1.2	-0.8	0.5	0.2	0.5	1.1	1.2
Shortness of breath walking on level ground	0.6	0.7	3.0	1.0	-0.5	1.7	0.6	0.0	0.0	0.2
Qualifications: College or University degree	0.2	0.5	1.3	1.1	-1.1	0.8	0.5	-0.3	0.1	0.2
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.4	0.9	-0.7	-0.3	0.2	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	-0.0	-0.1	0.7	-0.4	0.3	-0.3	-0.3
Emphysema/chronic bronchitis	0.4	0.4	1.0	-0.3	-0.1	0.9	1.0	-0.8	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.1	0.2	0.3	0.7	-0.9	-0.7	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.6	-0.6	-0.1	-1.1	1.1	-0.1	0.0
Medication: Blood pressure	0.3	0.6	1.9	-0.6	-1.0	-1.4	0.2	-0.5	-0.5	-0.5
Angina (self-reported)	0.2	0.3	1.4	-0.0	1.2	0.8	0.4	-0.1	0.1	-0.0
Migraine (self-reported)	0.7	0.8	2.0	0.1	1.0	0.7	-0.6	0.9	1.1	1.4
Medication: Ibuprofen	0.6	0.7	3.8	0.5	-2.0	-0.9	-0.0	-0.0	0.2	0.2
Medication: Allopurinol	2.0	2.6	3.7	-1.6	-1.9	1.3	1.4	-1.1	-1.9	-1.9
Medication: Omeprazole	0.7	0.8	1.7	1.2	0.6	0.3	-0.5	0.6	1.2	1.3
Medication: Seretide 50 evohaler	0.8	0.9	2.3	-0.8	-1.5	-1.1	0.2	-0.2	-1.0	-1.1
Mean time to correctly identify matches	1.0	1.8	3.2	-1.1	-0.9	-0.5	1.4	-1.8	-1.6	-1.7
Heart disease (mother)	1.4	1.7	3.0	-0.9	-1.5	0.4	1.3	-1.7	-1.3	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.6	0.3	-1.5	1.2	2.1	-2.1	-1.4	-1.2
Whole body fat mass	0.1	0.5	1.1	-1.0	0.6	-0.5	-0.8	0.7	0.6	0.7
Leg fat mass (right)	0.1	0.3	1.4	-1.2	0.4	-0.3	-0.5	0.3	0.4	0.4
Arm predicted mass (right)	0.1	0.7	1.9	-0.7	1.4	-0.3	-1.0	0.8	0.4	0.7
Pulse rate, automated reading	0.1	0.4	1.5	0.7	-1.2	-0.6	0.3	-0.6	-0.4	-0.3
Alcohol intake frequency.	0.2	0.6	1.0	-0.5	0.7	0.8	0.5	-0.6	-1.0	-1.0
Comparative height size at age 10	0.1	0.4	1.4	-1.2	-0.4	-0.8	-0.4	0.3	-0.3	-0.0
Number of full sisters	0.1	0.2	0.5	0.1	0.0	0.7	0.6	-0.5	-0.2	-0.1
Suffer from ‘nerves’	0.7	1.0	4.6	-0.5	0.3	-2.1	-0.6	0.4	1.1	0.8
Overall health rating	0.2	0.5	2.7	-0.8	-0.0	-1.6	-0.1	-0.2	0.1	0.0
Chest pain or discomfort	0.4	0.6	1.1	0.4	0.5	-0.8	-0.6	0.7	1.1	0.9
Had major operations	0.6	0.7	3.8	-0.9	0.0	-1.9	-0.4	0.2	0.1	0.0
Age at last live birth	1.3	1.8	4.3	-1.1	-0.4	0.5	1.2	-1.3	-2.1	-1.9
Family relationship satisfaction	1.3	1.7	6.5	2.5	-1.3	1.2	0.5	0.2	0.9	1.0
Leg pain on walking	0.7	0.8	1.7	-0.1	0.9	0.5	-1.0	1.3	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-0.6	0.8	-1.2	-0.9	0.6	0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	-0.2	-0.2	0.2	1.0	-0.7	-1.1	-0.9
Illness, injury, bereavement, stress in last 2 years	3.6	4.3	8.6	-0.9	-1.1	-0.6	2.9	-2.9	-2.4	-2.2
Medication: Aspirin	0.2	0.2	0.6	-0.1	0.8	0.4	0.7	-0.5	-0.2	-0.2
Supplements: Vitamin C	0.7	0.8	2.1	0.0	-0.3	-1.4	-1.3	1.1	0.7	0.6
Knee pain experienced in last month	0.5	0.7	1.6	-0.5	0.5	-1.0	-1.2	1.2	0.6	0.6
Hypertension (Self-reported)	0.1	0.4	1.3	-0.7	0.3	-1.1	-0.6	0.4	-0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	6.7	-1.2	-0.9	-2.6	-0.7	0.3	0.2	0.0
Illnesses of father: Heart disease	0.1	0.2	0.9	-0.9	0.2	-0.3	-0.3	-0.0	-0.3	-0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.6	-0.3	0.7	0.1	-0.4	0.2	0.1
Smoking status: Previous	1.2	1.8	7.4	-0.6	-2.7	0.1	1.0	-1.1	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.4	0.4	1.2	-1.1	-1.5	1.3	1.4	1.6
Whole body fat-free mass	0.1	0.6	2.2	-0.5	1.5	-0.4	-0.8	0.6	0.3	0.6
Leg fat-free mass (right)	0.1	0.7	2.6	-0.1	1.6	-0.3	-0.8	0.7	0.5	0.8
Arm fat percentage (left)	0.2	0.6	0.8	-0.7	0.4	-0.7	-0.9	0.8	0.9	0.9
Average weekly red wine intake	1.5	2.1	3.0	-0.8	1.7	-1.4	-1.6	1.7	1.4	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.7	3.0	-1.0	-0.4	-1.7	0.3	-0.5	-0.1	-0.2
Mood swings	0.7	1.2	4.1	-1.2	-1.4	-2.0	0.2	-0.3	-0.6	-0.7
Loneliness, isolation	1.4	2.0	3.2	1.4	1.8	-0.6	-1.4	1.6	1.4	1.4
Long-standing illness, disability or infirmity	1.1	1.7	3.3	-0.4	-1.8	1.5	1.3	-1.1	-1.3	-1.3
Ever had bowel cancer screening	2.9	3.4	5.2	0.6	2.3	-0.8	-1.9	2.1	2.2	2.1
Diabetes diagnosed by doctor	0.2	0.4	1.7	0.3	0.9	1.3	0.2	-0.1	-0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	-0.4	-1.3	1.2	0.4	-0.6	-0.7	-0.6
Friendships satisfaction	0.9	1.1	3.7	1.9	-0.4	0.8	0.4	0.2	1.0	1.5
Qualifications: nursing, teaching	0.6	0.9	2.1	0.1	-1.2	0.3	1.2	-1.4	-0.7	-0.6
Commuting to job workplace: Walk	1.2	1.3	2.6	0.5	0.8	-0.9	-1.1	1.0	1.6	1.6
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.5	0.1	0.5	0.4	-0.3	-0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	6.7	-1.1	-2.6	-0.5	0.6	-1.0	-0.8	-0.8
Medication for cholesterol	0.8	1.3	2.2	0.3	1.5	-0.2	-1.0	1.3	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	0.1	-0.9	0.7	1.0	-1.0	-0.8	-0.6
Back pain experienced in last month	0.2	0.3	0.8	-0.2	-0.2	0.2	-0.9	0.7	0.4	0.6
Mineral and other dietary supplements	0.8	1.1	2.9	0.5	0.5	1.7	0.9	-0.9	-1.2	-1.1
Breast cancer (self-reported)	0.2	0.3	0.8	-0.9	0.9	0.2	-0.0	0.2	0.4	0.4
Asthma (self-reported)	0.2	0.5	1.3	-1.1	-1.1	-0.8	-0.2	0.0	-0.3	-0.4
Osteoporosis (self-reported)	0.2	0.2	1.1	0.2	1.0	-0.7	-0.1	-0.1	0.0	-0.0
Osteoarthritis (self-reported)	1.0	1.3	2.7	1.6	-1.2	0.8	1.1	-0.8	-1.1	-1.0
Medication: Aspirin	0.1	0.2	0.5	0.2	0.7	0.2	0.6	-0.4	0.0	-0.0
Medication: Gliclazide	0.1	0.1	0.5	0.7	-0.3	0.1	0.3	-0.0	-0.0	0.0
Illnesses of father: None of the above (group 1)	0.6	0.7	2.0	1.4	-0.9	1.3	-0.1	0.4	0.5	0.6
Smoking status: Current	0.7	1.1	3.3	-0.7	1.8	0.2	-1.1	1.3	0.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.0	-1.0	0.0	-0.1	-0.3	0.5	0.0	0.0
Whole body water mass	0.1	0.6	2.1	-0.4	1.5	-0.3	-0.9	0.6	0.3	0.7
Leg predicted mass (right)	0.1	0.7	2.5	-0.0	1.6	-0.2	-0.9	0.8	0.6	0.8
Arm fat mass (left)	0.2	0.7	1.1	-1.0	0.8	-0.8	-1.0	0.8	0.7	0.8
Number of self-reported non-cancer illnesses	0.4	0.7	2.8	-1.1	-0.8	-1.7	-0.5	0.3	0.2	0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.1	-0.9	0.5	0.9	-0.6	-0.4	-0.3
Miserableness	0.1	0.2	0.8	-0.1	-0.9	0.1	0.5	-0.7	-0.3	-0.2
Guilty feelings	0.5	0.7	2.8	-0.5	-0.0	-1.7	0.6	-1.0	-0.6	-0.6
Wears glasses or contact lenses	1.0	1.2	4.5	2.1	0.9	1.3	-0.4	0.5	0.6	0.6
Ever taken oral contraceptive pill	5.6	6.3	9.5	2.1	3.1	1.2	-2.8	2.8	2.5	2.5
Hearing aid user	1.2	1.3	3.0	0.7	-1.7	1.4	1.0	-0.8	-1.1	-1.0
Mother’s age at death	0.3	0.4	1.6	1.0	0.1	1.2	-0.0	0.1	0.2	0.0
Financial situation satisfaction	1.4	1.8	6.0	2.4	-0.2	-0.6	-0.3	1.0	1.5	1.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.5	0.6	-0.8	0.7	1.9	-1.8	-1.1	-1.1
Commuting to job workplace: Public transport	0.3	0.4	1.0	0.5	1.0	0.3	-0.8	0.7	0.3	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.9	-0.7	-0.0	0.7	-0.8	-0.3	-0.3
Medication: Blood pressure	0.4	0.8	1.7	-1.3	-0.2	-0.3	0.5	-0.7	-1.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	0.9	0.1	0.7	0.3	-0.2	0.1	0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.6	0.2	-0.7	-1.1	-1.3	1.2	1.6	1.5
High cholesterol (Self-reported)	0.4	0.7	1.1	-1.0	0.5	0.3	0.9	-0.9	-1.0	-0.9
Medication: Bendroflumethiazide	0.8	1.1	5.1	-1.2	-0.5	-2.3	0.1	-0.6	-0.7	-0.7
Medication: Paracetamol	0.1	0.2	1.2	-0.1	-1.1	0.2	-0.2	0.3	0.0	0.1
Medication: Lisinopril	0.3	0.3	0.9	-0.8	-0.8	-1.0	-0.3	-0.1	-0.3	-0.2
Medication: Atorvastatin	0.7	0.9	3.0	0.5	0.4	1.7	0.8	-1.0	-0.8	-0.7
Illnesses of father: High blood pressure	0.9	1.1	2.7	-1.1	0.6	-1.4	-1.6	1.0	0.2	0.2
Alcohol drinker status: Never	0.5	0.6	1.3	0.3	1.2	0.2	-0.7	0.8	0.8	0.8
Ever smoked	1.7	3.0	4.0	-1.6	-1.7	0.2	2.0	-2.0	-1.9	-2.0
Basal metabolic rate	0.1	0.6	1.9	-0.6	1.4	-0.4	-0.9	0.6	0.3	0.6
Leg fat percentage (left)	0.1	0.4	1.8	-1.4	0.1	-0.3	-0.5	0.3	0.3	0.3
Arm fat-free mass (left)	0.1	0.5	1.6	-0.9	1.3	-0.2	-0.7	0.4	0.1	0.4
Number of operations (self-reported)	0.3	0.5	2.6	-0.1	-0.2	-1.6	-0.3	0.4	0.6	0.6
Average weekly beer plus cider intake	1.3	1.8	3.8	0.7	-0.7	1.9	1.7	-1.3	-1.4	-1.2
Irritability	0.1	0.1	0.6	-0.4	0.4	-0.8	-0.1	-0.1	-0.2	-0.1
Risk taking	0.0	0.0	0.0	0.0	-0.2	0.2	0.2	0.0	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	-0.3	1.1	-1.0	-1.0	1.4	1.0	1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.7	-0.6	-1.3	-1.2	0.7	-0.9	-0.8	-0.8
Age started oral contraceptive pill	0.3	0.4	1.5	0.4	1.0	1.2	0.1	0.0	0.2	0.2
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.6	-0.9	-0.5	0.3	-0.6	-0.5	-0.5
Ever depressed for a whole week	0.3	0.3	1.0	0.4	-0.4	-1.0	0.0	0.4	0.6	0.5
Unable to work because of sickness or disability	0.2	0.3	0.8	0.7	-0.1	0.9	-0.2	0.5	0.5	0.6
Commuting to job workplace: Cycle	1.1	1.3	2.8	1.3	0.1	0.2	-1.1	1.2	1.5	1.7
Myopia	2.2	3.2	7.2	-0.2	2.7	-1.6	-2.5	1.9	1.5	1.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.5	0.2	0.2	0.7	0.4	-0.2	-0.0	-0.0
Cholesterol lowering medication	1.1	1.6	2.6	-0.1	-0.4	1.4	1.4	-1.6	-1.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.7	1.0	0.7	0.3	-0.6	0.7	1.3	1.3
Pain experienced in last month	0.2	0.3	1.0	1.0	0.7	0.1	-0.2	-0.1	0.6	0.3
Supplements: Calcium	0.4	0.4	0.6	0.5	-0.2	-0.6	-0.8	0.5	0.8	0.8
Basal cell carcinoma (self-reported)	2.3	2.7	5.0	-0.1	1.9	-0.6	-2.2	2.2	1.7	1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.3	-0.4	-0.2	1.1	-0.9	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.8	-0.9	1.3	-0.0	0.1	-0.2	-0.1	0.0
Heart disease (siblings)	0.6	0.7	2.1	-1.5	1.1	-1.0	-0.5	0.1	-0.1	-0.5
Alcohol drinker status: Previous	0.8	0.9	1.3	0.9	0.9	0.4	-0.9	1.0	1.1	1.1
Pack years of smoking	0.1	0.1	0.4	-0.2	0.6	0.0	0.2	-0.2	-0.3	-0.4
Impedance of whole body	0.0	0.2	1.2	-0.2	-1.1	-0.3	0.1	-0.0	-0.2	-0.5
Leg fat mass (left)	0.1	0.5	1.8	-1.3	0.6	-0.5	-0.6	0.4	0.4	0.5
Arm predicted mass (left)	0.1	0.4	1.8	-1.4	0.9	-0.5	-0.3	-0.0	-0.4	-0.1