Hub : Genes

COG8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.091	0.026	1.9e-12	0.132	0.112	0.140	0.118	0.142	9.8e-16	1.8e-13	1.2e-16	3.2e-14	6.9e-17
2	GTEx	Artery Aorta	0.082	0.034	7.5e-04	-0.004	NA	0.003	NA	0.009	6.1e-01	NA	2.1e-01	NA	9.8e-02
3	GTEx	Esophagus Muscularis	0.061	0.032	6.6e-03	0.053	NA	0.016	NA	0.039	3.8e-04	NA	3.5e-02	NA	2.1e-03
4	GTEx	Thyroid	0.071	0.033	1.7e-03	0.001	NA	-0.002	NA	-0.002	2.8e-01	NA	5.2e-01	NA	5.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	6.3	9.9	11.2	3.3	-3.2	-3.3	-2.6
Bipolar Disorder or Schizophrenia	6.6	16.0	22.8	4.8	-3.6	-4.8	-2.4
Depressed Affect (Nagel 2018)	0.6	1.3	1.7	1.3	0.8	-1.1	1.2
Depression (Nagel 2018)	0.9	1.3	2.7	1.6	0.1	-1.5	0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.5	-1.5	-0.0	1.6	-0.3
Neuroticism (Nagel 2018)	0.8	1.8	4.0	0.2	1.8	0.1	2.0
Schizophrenia (2018)	3.4	7.1	11.9	3.5	-2.0	-3.4	-0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.8	0.4	1.0	-0.4	1.3
Worry (Nagel 2018)	1.4	2.9	4.3	-1.5	2.1	1.6	1.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.2	-0.4	-0.1	-0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.5	-0.1	-0.2	0.1	-0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.7	-0.4	-0.6	-0.8
Crohns Disease (2017)	0.5	1.1	2.1	-1.4	0.3	1.4	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	0.2	-1.2	-0.3	-0.6
Ulcerative Colitis (UC)	2.1	3.9	5.6	1.8	-2.4	-1.9	-1.8
Major Depression (MDD)	0.1	0.2	0.4	-0.3	0.6	0.5	0.2
Reaction Time	0.5	1.0	2.4	-0.3	1.2	0.2	1.5
Verbal and Numeric Reasoning (VNR)	1.2	3.0	5.3	-2.3	0.9	2.3	0.7
Breast Cancer	0.1	0.3	0.6	-0.4	0.8	0.3	0.7
Ovarian Cancer	0.6	0.8	1.7	-0.8	-0.6	0.6	-1.3
Prostate Cancer	0.2	0.3	0.9	-0.3	0.2	0.5	0.9
Age at First Birth	1.0	1.5	2.0	1.4	-1.2	-1.4	-0.8
Bipolar Disorder (2011)	0.3	0.3	0.5	0.3	-0.7	-0.6	-0.3
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1
Coronary Artery Disease (CAD)	1.3	1.5	2.3	-1.0	1.3	1.0	1.5
Crohns Disease (2012)	0.3	0.4	0.9	-0.9	0.1	0.8	0.4
Mean Putamen Volume	4.0	4.6	5.1	2.1	-2.2	-2.3	-2.0
Fasting Glucose	0.3	0.4	0.9	1.0	-0.1	-0.7	0.1
HbA1C	0.6	0.6	1.7	-0.2	-0.8	0.3	-1.3
HDL Cholesterol	1.5	2.5	3.9	-1.1	2.0	1.3	1.8
LDL Cholesterol	0.2	0.3	0.7	-0.3	-0.7	0.4	-0.8
Lupus	0.5	0.8	1.8	1.2	-0.4	-1.3	-0.2
Neuroticism (2016)	2.5	3.6	6.7	-0.9	2.4	1.0	2.6
Primary Biliary Cirrhosis	1.2	1.7	2.2	1.4	-1.1	-1.5	-1.2
Rheumatoid Arthritis	0.3	0.4	0.5	0.6	-0.7	-0.4	-0.7
Schizophrenia (2014)	3.3	7.2	12.6	3.6	-1.9	-3.5	-0.8
Triglycerides	1.8	3.0	4.4	1.3	-2.1	-1.3	-2.1
Type 2 Diabetes (T2D) (2012)	2.7	3.1	4.6	-2.1	1.3	2.1	1.4
Ulcerative Colitis	1.9	2.8	4.6	1.0	-2.2	-1.2	-2.0
Blood Eosinophil Count	0.9	6.8	13.3	1.1	-3.6	-1.2	-3.4
Blood Platelet Count	0.5	6.1	8.3	-2.1	2.7	2.1	2.9
Blood Red Count	0.5	4.6	9.2	-3.0	0.8	3.0	0.1
Blood White Count	0.5	4.0	7.6	1.6	-2.8	-1.7	-1.7
Heel T-Score	1.8	14.2	18.1	3.2	-4.3	-3.2	-4.3
BMI	0.6	3.6	8.0	1.5	-2.8	-1.6	-1.2
Height	3.5	67.3	81.4	-8.3	9.0	8.5	6.8
Waist Hip Ratio (WHR)	0.8	3.5	4.6	-2.0	1.8	2.2	1.4
Systolic Blood Pressure	0.2	1.2	2.6	-0.7	-1.0	0.7	-1.6
Smoking Status	0.8	2.0	5.5	0.4	1.4	-0.5	2.3
Allergy or Eczema	0.3	0.7	1.5	0.1	-1.2	-0.2	-1.1
Cardiovascular Disease	0.8	2.6	5.2	-2.3	0.2	2.3	-0.2
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.2	0.0	0.3	-0.3
Respiratory disease	0.0	0.0	0.1	0.1	-0.3	-0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.7	-0.3	-0.5	0.2
Lung FEV1/FVC ratio	0.0	0.2	0.5	-0.7	0.2	0.6	-0.0
Lung FVC	0.5	2.5	4.2	-1.4	2.1	1.3	1.4
Neuroticism	0.8	1.8	3.9	0.0	1.9	0.1	2.0
Chronotype (morning person)	0.9	2.0	2.7	-1.6	1.4	1.5	0.9
Hair Pigment	0.0	1.1	2.9	0.6	1.1	0.3	1.7
Tanning	0.1	1.0	1.6	-0.8	1.0	0.7	1.3
Hand grip strength (left)	0.1	0.2	0.6	-0.5	0.8	0.3	-0.1
Number of treatments/medications taken	0.2	0.4	0.8	0.9	-0.4	-0.8	-0.0
Average weekly spirits intake	0.1	0.1	0.2	-0.1	-0.5	-0.1	-0.0
Sensitivity / hurt feelings	3.6	6.1	7.6	-2.3	2.5	2.3	2.8
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.1	2.0	-0.2	-1.8	0.8
Hearing difficulty/problems: Yes	1.9	2.8	7.5	0.3	-1.9	-0.3	-2.7
Relative age of first facial hair	0.1	0.2	0.6	0.0	-0.6	0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.9	-0.2	-0.9	0.2
Ever used hormone-replacement therapy (HRT)	1.4	1.7	2.9	-1.1	1.7	1.0	1.4
Ever had hysterectomy (womb removed)	0.5	0.6	0.7	0.9	-0.6	-0.8	-0.7
Systolic blood pressure, automated reading	0.2	0.6	1.2	0.2	-1.1	-0.2	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	-0.9	0.3	0.7	0.5
Angina	2.1	2.8	6.1	-0.7	1.9	0.9	2.5
Medication for hormone replacement therapy	4.0	4.5	7.6	-1.3	2.7	1.3	2.6
Vitamin and mineral supplements	1.2	1.6	3.2	-1.7	0.0	1.8	0.1
Supplements: Zinc	0.2	0.2	0.5	0.3	0.3	-0.3	0.7
Medication: Co-codamol	0.3	0.3	0.5	0.7	0.4	-0.5	0.7
Medication: Metformin	0.3	0.5	1.4	0.2	0.7	-0.1	1.2
Diabetes (father)	1.3	1.6	2.6	1.6	-1.0	-1.6	-0.4
Diabetes (mother)	0.1	0.2	0.5	0.7	-0.1	-0.4	-0.1
Severe depression (siblings)	4.8	5.4	7.9	2.8	-1.9	-2.8	-1.6
Pack years adult smoking proportion	3.2	4.8	6.3	2.0	-2.5	-1.9	-2.4
Impedance of leg (right)	0.2	1.1	2.3	-0.8	1.5	1.1	0.5
Leg fat-free mass (left)	1.0	5.2	8.0	-2.0	2.3	1.9	2.8
Trunk fat percentage	0.1	0.5	1.8	-0.4	0.1	0.5	1.3
Hand grip strength (right)	0.1	0.4	0.6	-0.6	0.8	0.5	-0.4
Townsend deprivation index at recruitment	3.9	5.4	7.0	2.6	-2.4	-2.5	-1.6
Current tobacco smoking	1.8	2.9	5.9	2.2	-0.2	-2.4	0.9
Average weekly fortified wine intake	0.8	1.0	2.1	-1.4	0.1	1.4	-0.2
Maternal smoking around birth	0.1	0.1	0.5	-0.0	-0.2	-0.0	0.7
Fed-up feelings	1.2	2.2	5.8	0.4	1.6	-0.2	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	1.1	-0.0	-0.9	0.2
Relative age voice broke	0.0	0.1	0.1	-0.3	0.0	0.2	-0.3
Taking other prescription medications	0.8	1.3	2.6	1.6	-0.5	-1.5	0.3
Age when periods started (menarche)	2.4	5.7	7.6	-2.4	2.8	2.3	2.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.9	-0.7	1.7	0.8	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.9	0.9	-2.0	-0.9	-1.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.7	2.4	1.1	-1.4	-1.0	-1.5
Qualifications: CSEs or equivalent	0.5	0.7	1.4	0.1	1.2	-0.1	1.2
Serious illness, injury or assault to yourself	1.1	1.4	1.7	1.2	-1.3	-1.3	-0.7
High blood pressure	2.7	7.6	11.6	-3.4	2.1	3.4	1.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.1	-0.8	0.1	-0.5
Multivitamins +/- minerals	0.8	1.1	2.2	1.4	-0.2	-1.5	-0.1
Stomach or abdominal pain in last month	0.8	1.0	2.2	-0.3	1.5	0.4	1.3
Supplements: Glucosamine	5.9	7.7	10.5	3.2	-2.5	-3.2	-1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	-0.2	0.7	0.3	0.8
Medication: Atenolol	0.2	0.2	0.4	-0.6	0.1	0.6	0.3
Medication: Levothyroxine sodium	0.4	0.7	1.0	1.0	-0.5	-0.9	-0.8
Sitting height	6.1	43.5	53.3	-6.9	7.3	6.9	5.0
Chronic bronchitis/emphysema (father)	9.9	11.6	13.3	3.6	-3.5	-3.6	-2.9
High blood pressure (mother)	0.5	0.8	1.5	-1.1	-0.0	1.2	-0.6
Body mass index (BMI)	0.5	2.3	3.2	1.6	-1.8	-1.8	0.1
Impedance of leg (left)	0.2	1.1	2.4	-0.9	1.5	1.1	0.5
Leg predicted mass (left)	1.0	5.3	8.0	-2.0	2.3	1.9	2.8
Trunk fat mass	0.5	2.1	4.8	-1.1	1.0	1.2	2.2
Waist circumference	0.1	0.5	2.1	0.1	0.2	-0.1	1.4
Number of incorrect matches in round	0.5	0.8	1.1	1.0	-0.6	-1.1	-0.8
Past tobacco smoking	2.6	4.8	6.2	1.8	-2.5	-1.9	-2.5
Alcohol usually taken with meals	0.3	0.5	1.0	-1.0	0.3	0.9	-0.3
Nervous feelings	3.9	7.3	8.7	-2.9	2.9	3.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.3	11.1	3.3	-0.5	-3.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.4	-0.6	0.3	0.6	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	0.7	-0.6	-0.6	-0.9
Had menopause	0.6	0.8	1.5	-1.1	0.5	1.2	0.2
Had other major operations	0.4	0.5	1.3	-0.0	0.7	0.2	1.2
Forced vital capacity (FVC)	4.0	15.4	19.6	-4.1	4.4	4.1	2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.5	1.1	-1.9	-1.0	-1.8
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.5	1.0	0.9	-0.9	2.1
Qualifications: None of the above	0.1	0.3	0.4	-0.4	0.5	0.5	0.7
Financial difficulties in last 2 years	0.6	0.8	1.6	1.3	-0.4	-1.2	0.4
Mouth/teeth dental problems	2.3	3.5	7.7	1.0	-2.1	-1.0	-2.8
Heart attack	0.9	1.1	2.1	-0.9	0.7	1.0	1.5
Allergy	0.1	0.2	0.5	0.2	0.7	-0.2	0.2
Pain all over the body in last month	0.4	0.4	0.8	0.3	0.9	-0.3	0.9
Diabetes (self-reported)	1.8	2.8	6.0	-0.9	1.8	1.0	2.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.2	-0.4	0.2	-0.6
Medication: Ramipril	0.4	0.5	1.1	-0.9	-0.3	1.1	-0.2
Medication: Simvastatin	0.2	0.2	0.6	0.1	-0.8	-0.1	-0.6
Fluid intelligence score	0.6	1.2	1.9	-1.4	0.9	1.4	0.5
Illnesses of siblings	0.1	0.2	0.4	0.5	0.3	-0.7	0.1
Neuroticism score	1.5	3.2	6.9	-0.2	2.4	0.4	2.6
Weight	0.8	3.8	7.7	-1.5	1.8	1.4	2.8
Impedance of arm (right)	1.5	6.9	9.2	-2.8	2.6	3.0	1.8
Arm fat percentage (right)	0.2	0.6	1.5	0.5	-1.2	-0.6	0.5
Trunk fat-free mass	1.2	7.1	8.5	-2.5	2.8	2.4	2.9
Hip circumference	0.1	0.6	0.8	0.7	-0.6	-0.9	0.9
Time employed in main current job	0.7	0.8	1.1	-1.0	0.9	1.0	0.5
Alcohol intake versus 10 years previously	1.1	1.7	2.2	1.3	-1.5	-1.2	-1.3
Father’s age at death	2.0	2.7	4.6	1.3	-1.7	-1.3	-2.1
Worrier / anxious feelings	1.8	3.4	4.0	-1.7	2.0	1.9	1.7
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.2	12.6	3.5	-0.7	-3.3	0.7
Falls in the last year	0.0	0.1	0.1	0.1	-0.2	-0.2	0.4
Hair/balding pattern: Pattern 3	1.4	2.1	3.2	-1.2	1.5	1.3	1.8
Number of live births	1.0	1.5	2.9	0.6	-1.5	-0.6	-1.7
Forced expiratory volume in 1-second (FEV1)	3.8	12.9	15.9	-3.9	4.0	3.8	2.3
Pulse rate	0.1	0.2	0.4	0.6	0.2	-0.5	0.3
Happiness	1.5	1.8	3.3	1.8	-0.8	-1.8	0.4
Noisy workplace	1.5	1.8	2.2	1.3	-1.5	-1.2	-1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.9	0.7	-1.3	-0.8	-2.0
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	3.9	1.3	-2.0	-1.4	-1.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	0.8	-0.0	-0.7	1.0
Asthma	0.1	0.3	0.8	-0.2	0.4	0.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	5.7	7.3	9.2	3.0	-2.4	-2.9	-2.3
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.1	0.3	0.5
Depression (self-reported)	2.3	2.7	4.9	2.2	-1.0	-2.1	-0.7
Medication: Lansoprazole	4.9	5.5	6.4	-2.2	2.5	2.3	2.3
Prospective memory result	1.2	1.4	1.7	-1.1	1.3	1.1	1.3
Lung cancer (father)	0.0	0.1	0.1	0.3	-0.1	-0.3	-0.0
Illnesses of mother	0.2	0.3	0.8	0.6	-0.2	-0.9	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.8	15.1	-3.6	3.9	3.6	2.4
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.1	0.1	0.3	0.0
Impedance of arm (left)	1.1	4.9	7.4	-2.5	2.2	2.7	1.1
Arm fat mass (right)	0.1	0.5	2.0	0.1	-0.3	-0.1	1.4
Trunk predicted mass	1.2	7.1	8.4	-2.5	2.8	2.4	2.9
Standing height	4.9	48.5	61.8	-6.9	7.9	7.0	5.9
Length of working week for main job	4.6	5.1	5.4	2.2	-2.3	-2.3	-2.2
Exposure to tobacco smoke at home	0.6	0.7	1.4	1.2	-0.4	-1.1	-0.1
Breastfed as a baby	0.6	0.8	1.0	0.8	-0.9	-1.0	-0.9
Tense / ‘highly strung’	0.9	1.5	3.1	0.4	1.6	-0.2	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.5	1.1	-0.1	-1.2	-0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.2	0.1	0.2	0.1
Birth weight of first child	1.2	2.2	2.7	1.5	-1.4	-1.4	-1.6
Peak expiratory flow (PEF)	2.7	6.3	8.8	-3.0	2.6	2.9	1.2
Pulse wave reflection index	4.2	5.1	7.2	-2.7	2.0	2.6	1.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.1	1.5	0.3	-1.4	0.9
Loud music exposure frequency	4.5	4.9	7.0	-2.7	1.9	2.6	1.5
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.3	1.4	-1.2	-1.5	-1.4
Mouth/teeth dental problems: Bleeding gums	6.0	7.7	8.7	-2.7	3.0	2.7	2.8
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	-0.4	0.2	-0.5
Medication: Paracetamol	0.5	0.9	2.2	0.4	1.1	-0.2	1.5
Headache pain in last month	1.0	1.8	2.9	1.7	0.6	-1.6	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	0.9	-0.3	-0.9	-0.3
Glaucoma (self-reported)	0.5	0.6	0.7	-0.8	0.7	0.8	0.8
Gout (self-reported)	1.7	2.4	4.0	1.3	-1.4	-1.3	-2.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.2	0.2	-0.1	0.3
Medication: Amlodipine	0.2	0.2	0.5	-0.7	0.1	0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.4	-0.6	-0.2	-0.5
Birth weight	0.8	1.7	3.1	-0.9	1.8	1.0	1.3
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.1	1.5	-0.8	-1.3	-0.5
High blood pressure (siblings)	0.4	0.6	1.3	-0.0	-1.1	0.1	-1.1
Forced vital capacity (FVC), Best measure	3.9	14.3	19.6	-3.8	4.4	3.8	3.0
Body fat percentage	0.1	0.3	0.9	0.3	-0.5	-0.2	1.0
Leg fat percentage (right)	0.5	1.7	2.5	1.5	-1.6	-1.5	0.1
Arm fat-free mass (right)	0.8	4.0	5.6	-1.7	2.2	1.6	2.4
Exposure to tobacco smoke outside home	0.5	0.7	2.0	-0.2	0.8	0.2	1.4
Comparative body size at age 10	0.1	0.3	0.8	-0.5	-0.1	0.5	0.9
Number of full brothers	0.1	0.1	0.3	0.5	-0.2	-0.6	-0.0
Worry too long after embarrassment	0.2	0.4	0.8	0.2	0.9	0.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	7.4	9.6	11.8	3.4	-3.0	-3.4	-2.5
Wheeze or whistling in the chest in last year	1.2	2.1	4.0	-1.0	1.5	1.0	2.0
Number of children fathered	2.3	2.6	4.9	-0.6	2.2	0.6	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-1.2	0.3	1.1	0.1
Age at first live birth	0.2	0.4	0.5	0.6	-0.3	-0.7	-0.7
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	0.4	0.2	0.2
Health satisfaction	4.8	6.3	11.3	3.4	-1.5	-3.3	-0.8
Shortness of breath walking on level ground	1.3	1.5	2.6	1.6	-1.0	-1.6	-0.2
Qualifications: College or University degree	1.6	5.0	9.0	1.6	-2.5	-1.6	-3.0
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.2	-0.4	-0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	-0.0	0.9	-0.1	1.5
Emphysema/chronic bronchitis	1.4	1.6	2.1	1.4	-1.3	-1.4	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-1.3	0.7	1.0	0.5
Neck or shoulder pain in last month	0.7	1.0	2.0	1.4	0.3	-1.3	0.4
Medication: Blood pressure	0.9	1.7	2.9	-1.7	0.8	1.7	0.5
Angina (self-reported)	2.0	2.6	6.2	-0.5	1.9	0.7	2.5
Migraine (self-reported)	1.0	1.3	2.7	1.5	0.1	-1.6	0.6
Medication: Ibuprofen	7.3	8.7	11.1	3.3	-2.8	-3.3	-2.3
Medication: Allopurinol	1.2	1.5	2.7	1.0	-1.2	-1.0	-1.6
Medication: Omeprazole	0.9	1.1	1.7	0.9	-1.3	-0.8	-1.1
Medication: Seretide 50 evohaler	3.8	4.3	5.4	1.9	-2.3	-1.8	-2.2
Mean time to correctly identify matches	1.0	1.8	2.3	-1.2	1.4	1.2	1.5
Heart disease (mother)	0.5	0.6	0.8	-0.9	0.6	0.9	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	0.8	-0.3	-0.9	0.3
Whole body fat mass	0.2	0.9	3.2	-0.4	0.4	0.4	1.8
Leg fat mass (right)	0.1	0.5	1.7	0.4	-0.2	-0.4	1.3
Arm predicted mass (right)	1.0	5.0	7.1	-1.9	2.5	1.8	2.7
Pulse rate, automated reading	0.3	0.9	1.4	1.2	-0.7	-1.0	-0.8
Alcohol intake frequency.	7.0	16.2	19.2	4.4	-4.2	-4.4	-2.9
Comparative height size at age 10	3.3	18.4	22.9	-3.8	4.8	3.8	4.8
Number of full sisters	1.3	1.6	2.0	-1.4	1.2	1.2	1.2
Suffer from ‘nerves’	2.1	3.4	4.5	-1.7	2.1	1.8	1.7
Overall health rating	0.7	1.5	2.0	1.4	0.4	-1.3	1.4
Chest pain or discomfort	1.1	1.6	4.2	0.2	1.5	-0.1	2.1
Had major operations	0.2	0.2	0.7	-0.2	0.4	0.1	0.8
Age at last live birth	0.1	0.1	0.2	-0.5	0.1	0.3	-0.1
Family relationship satisfaction	0.3	0.4	0.7	0.8	-0.0	-0.7	0.5
Leg pain on walking	3.8	4.8	9.2	2.9	-1.1	-3.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.1	0.2	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.2	-0.1	-0.2	0.4
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	5.5	-2.3	1.7	2.3	0.7
Medication: Aspirin	0.1	0.1	0.3	-0.4	0.1	0.5	-0.0
Supplements: Vitamin C	0.4	0.4	1.0	-0.3	1.0	0.2	0.7
Knee pain experienced in last month	1.3	2.0	3.9	1.9	-0.2	-2.0	0.7
Hypertension (Self-reported)	3.0	8.2	12.0	-3.4	2.3	3.5	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.8	-1.2	0.9	1.3	0.4
Illnesses of father: Heart disease	0.4	0.5	1.0	1.0	-0.1	-1.0	0.1
Illnesses of siblings: Diabetes	1.0	1.2	2.4	1.5	-0.4	-1.4	0.6
Smoking status: Previous	5.2	7.8	8.9	-2.9	2.8	3.0	2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	5.7	-1.2	2.4	1.3	1.8
Whole body fat-free mass	1.2	7.1	9.3	-2.4	2.8	2.3	3.0
Leg fat-free mass (right)	1.0	5.2	7.5	-2.0	2.3	2.0	2.7
Arm fat percentage (left)	0.2	0.7	1.9	0.7	-1.4	-0.7	0.3
Average weekly red wine intake	3.4	5.0	7.4	-2.7	2.0	2.7	1.2
Handedness (chirality/laterality): Left-handed	3.7	4.5	5.1	-2.1	2.3	2.2	1.9
Mood swings	0.6	1.1	2.4	0.7	1.2	-0.4	1.5
Loneliness, isolation	0.8	1.0	2.5	0.5	1.1	-0.4	1.6
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.6	-0.7	-0.4	0.1
Ever had bowel cancer screening	8.4	9.8	11.5	-3.4	3.1	3.3	2.7
Diabetes diagnosed by doctor	0.7	1.2	3.2	0.1	1.2	0.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.8	1.5	-1.3	-1.7	-0.6
Friendships satisfaction	0.7	0.8	1.4	0.9	0.7	-0.8	1.2
Qualifications: nursing, teaching	5.6	8.8	9.8	3.1	-3.0	-3.1	-2.7
Commuting to job workplace: Walk	0.5	0.5	0.9	0.5	-0.8	-0.4	-0.9
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.4	0.1	-0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.5	-1.2	1.0	1.2	0.9
Medication for cholesterol	3.3	5.1	5.6	2.3	-2.4	-2.3	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	1.0	-0.0	-1.0	0.0
Back pain experienced in last month	1.0	1.5	2.1	1.4	0.5	-1.5	1.2
Mineral and other dietary supplements	3.1	4.1	5.7	-2.4	1.6	2.4	1.5
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	0.1	-0.3	-0.0
Asthma (self-reported)	0.4	0.7	1.7	-0.4	0.8	0.6	1.3
Osteoporosis (self-reported)	1.6	2.0	2.6	-1.5	1.4	1.6	1.1
Osteoarthritis (self-reported)	0.7	0.9	1.8	1.3	-0.5	-1.3	-0.1
Medication: Aspirin	0.2	0.2	0.4	-0.5	0.3	0.6	0.3
Medication: Gliclazide	0.6	0.7	1.6	1.3	0.2	-1.1	0.4
Illnesses of father: None of the above (group 1)	3.2	3.9	5.1	-1.8	2.1	1.7	2.3
Smoking status: Current	2.5	4.0	8.1	2.7	-0.3	-2.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	-1.1	0.3	1.0	-0.5
Whole body water mass	1.2	6.7	9.2	-2.3	2.7	2.2	3.0
Leg predicted mass (right)	1.0	5.5	8.0	-2.1	2.4	2.0	2.8
Arm fat mass (left)	0.1	0.6	2.2	-0.2	-0.1	0.1	1.5
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	0.1	-0.2	-0.0	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.2	0.6	-0.2	0.1
Miserableness	0.6	1.0	2.2	1.5	-0.0	-1.3	0.1
Guilty feelings	0.9	1.3	2.7	1.6	0.2	-1.5	0.5
Wears glasses or contact lenses	0.1	0.1	0.4	0.0	-0.5	0.1	-0.6
Ever taken oral contraceptive pill	0.7	0.8	1.4	1.2	-0.5	-1.2	-0.3
Hearing aid user	5.2	5.9	7.3	2.6	-2.2	-2.7	-2.1
Mother’s age at death	2.5	3.1	4.5	-2.1	1.5	2.1	1.0
Financial situation satisfaction	1.1	1.3	2.4	1.4	-0.9	-1.6	-0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	0.8	-1.1	-0.7	-0.7
Commuting to job workplace: Public transport	1.5	1.8	2.5	-1.6	1.3	1.5	0.8
Eye problems/disorders: Glaucoma	3.6	4.2	4.8	-2.1	1.8	2.2	2.1
Medication: Blood pressure	2.7	5.0	7.8	-2.8	1.8	2.8	1.3
Pain type(s) experienced in last month: Hip pain	2.5	3.2	6.7	-1.0	2.0	1.0	2.6
Supplements: Fish oil (including cod liver oil)	2.0	2.6	3.1	1.8	-1.4	-1.7	-1.6
High cholesterol (Self-reported)	0.8	1.4	3.2	0.4	-1.5	-0.5	-1.8
Medication: Bendroflumethiazide	3.0	4.6	9.5	-3.1	0.8	2.9	0.3
Medication: Paracetamol	0.6	0.9	1.9	1.4	0.1	-1.2	0.5
Medication: Lisinopril	0.0	0.1	0.1	-0.2	-0.3	0.3	-0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.1	0.2	-0.0	0.3
Illnesses of father: High blood pressure	0.5	0.6	1.6	-0.5	-0.7	0.4	-1.3
Alcohol drinker status: Never	0.9	1.1	2.1	0.8	-1.4	-0.8	-1.0
Ever smoked	2.4	4.2	5.8	-1.7	2.4	1.7	2.3
Basal metabolic rate	1.0	5.6	8.6	-2.0	2.4	2.0	2.9
Leg fat percentage (left)	0.4	1.6	2.2	1.4	-1.5	-1.5	0.2
Arm fat-free mass (left)	1.0	4.9	7.8	-1.8	2.3	1.8	2.8
Number of operations (self-reported)	0.5	0.8	2.4	0.3	0.8	-0.2	1.6
Average weekly beer plus cider intake	0.2	0.3	0.4	-0.6	-0.4	0.6	-0.5
Irritability	2.7	4.6	8.9	3.0	-0.4	-3.0	0.7
Risk taking	0.6	0.8	1.1	1.0	0.6	-1.0	1.0
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.3	1.2	-1.4	-1.2	-1.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.1	0.2	-0.2	0.5
Age started oral contraceptive pill	5.0	6.2	8.9	-3.0	2.2	2.9	1.6
Diastolic blood pressure, automated reading	5.5	17.2	18.2	-4.0	4.2	4.1	4.3
Ever depressed for a whole week	0.2	0.2	0.8	0.1	0.5	-0.1	0.9
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.1	-0.4	0.2	-0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.4	0.2	0.4	0.4
Myopia	3.1	4.5	6.7	-2.4	1.8	2.6	1.5
Vascular/heart problems diagnosed by doctor	2.5	6.7	10.6	3.2	-1.9	-3.3	-1.6
Cholesterol lowering medication	0.6	0.9	2.2	0.4	-1.0	-0.3	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.4	0.6	-0.7	-0.5	-0.5
Pain experienced in last month	1.2	2.0	3.3	-1.3	-1.3	1.2	-1.8
Supplements: Calcium	0.1	0.1	0.2	0.1	0.5	0.0	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-0.1	-1.1	0.2	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.1	-0.9	0.7	1.1	1.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	-0.2	0.4	-0.3
Heart disease (siblings)	0.5	0.6	1.2	-1.0	-0.4	1.1	-0.5
Alcohol drinker status: Previous	3.9	4.4	5.1	2.3	-2.1	-2.2	-1.8
Pack years of smoking	2.7	4.0	5.4	1.7	-2.3	-1.6	-2.3
Impedance of whole body	0.7	3.6	4.9	-1.9	2.2	2.2	1.0
Leg fat mass (left)	0.1	0.5	1.8	0.4	-0.2	-0.4	1.3
Arm predicted mass (left)	0.9	4.7	7.8	-1.7	2.3	1.6	2.8