Hub : Genes

COL27A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.122	0.039	3.9e-04	0.017	0.037	0.022	0.039	0.044	0.00330	2.3e-05	1.0e-03	1.5e-05	3.9e-06
2	GTEx	Cells Transformed fibroblasts	0.320	0.070	4.1e-07	0.057	NA	0.067	NA	0.137	0.00004	NA	9.4e-06	NA	2.0e-10
3	GTEx	Skin Sun Exposed Lower leg	0.254	0.059	1.0e-04	0.037	NA	0.097	NA	0.091	0.00048	NA	2.1e-08	NA	5.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.5	2.4	0.6	1.5	-1.3
Bipolar Disorder or Schizophrenia	0.4	0.9	2.2	-0.7	1.5	-0.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	-0.3	0.6	1.2
Depression (Nagel 2018)	0.8	1.2	2.6	-0.9	-1.6	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.1	-0.4	1.2	1.5
Neuroticism (Nagel 2018)	0.6	1.5	4.1	0.3	0.4	2.0
Schizophrenia (2018)	0.5	1.0	2.0	-1.4	0.7	0.7
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	-0.2	0.3	0.2
Worry (Nagel 2018)	0.4	0.8	1.6	-1.0	0.1	1.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	0.6	-0.1
Alzheimer’s Disease (in father)	1.1	1.2	2.9	-0.8	-0.4	-1.7
Alzheimer’s Disease (including proxy)	0.8	1.2	2.9	-1.7	0.0	-0.8
Crohns Disease (2017)	0.3	0.7	0.8	-0.8	0.9	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.3	0.4	-0.7
Ulcerative Colitis (UC)	0.5	0.9	2.5	-0.3	0.0	-1.6
Major Depression (MDD)	1.8	2.2	6.5	0.0	0.4	-2.5
Reaction Time	1.2	2.4	5.5	2.3	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.0	-0.3	-0.3	2.0
Breast Cancer	0.2	0.5	0.6	-0.7	-0.6	0.7
Ovarian Cancer	0.3	0.3	0.6	-0.5	-0.8	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	3.6	0.1	-1.9	-0.6
Bipolar Disorder (2011)	0.6	0.5	0.9	-1.0	0.8	-0.3
Body Mass Index (BMI) (2010)	1.3	1.7	4.7	0.5	-0.5	-2.2
Coronary Artery Disease (CAD)	1.5	1.8	4.0	-2.0	1.1	0.3
Crohns Disease (2012)	0.6	0.9	2.0	-1.4	0.6	0.6
Mean Putamen Volume	3.6	4.1	9.6	3.1	1.6	-0.3
Fasting Glucose	0.8	1.0	1.9	1.4	-0.8	-0.7
HbA1C	2.4	2.7	5.7	2.4	0.5	-1.4
HDL Cholesterol	1.7	2.8	7.7	0.3	2.8	-0.8
LDL Cholesterol	0.7	1.2	2.6	0.8	1.6	0.5
Lupus	0.2	0.4	0.6	-0.7	0.8	-0.0
Neuroticism (2016)	0.6	0.8	1.4	1.2	-0.9	0.5
Primary Biliary Cirrhosis	0.6	0.8	1.7	-1.3	0.8	0.4
Rheumatoid Arthritis	0.2	0.2	0.4	0.2	0.5	0.6
Schizophrenia (2014)	0.3	0.6	0.9	-0.9	0.9	0.4
Triglycerides	0.2	0.3	0.5	-0.7	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	-0.1	-1.4	0.7
Ulcerative Colitis	0.5	0.7	1.8	-0.4	-0.1	-1.3
Blood Eosinophil Count	0.2	1.5	4.0	0.1	-2.0	0.7
Blood Platelet Count	0.1	0.8	1.6	0.8	0.1	1.3
Blood Red Count	0.4	3.4	9.2	0.7	-3.0	0.8
Blood White Count	0.4	3.2	6.5	-1.6	-2.5	-0.7
Heel T-Score	0.2	1.8	3.2	1.0	-1.8	1.1
BMI	0.1	0.7	0.8	-0.8	-0.9	-0.7
Height	1.0	19.0	45.4	-6.7	-2.5	2.3
Waist Hip Ratio (WHR)	1.0	4.5	6.7	-2.6	-2.6	-0.5
Systolic Blood Pressure	0.4	1.9	5.2	-0.5	-2.3	-0.3
Smoking Status	0.9	2.1	5.1	-1.0	-2.3	0.5
Allergy or Eczema	0.2	0.4	1.3	-0.3	1.1	0.0
Cardiovascular Disease	1.2	4.0	5.3	-1.7	-2.0	-2.3
Hypothyroidism (self reported)	0.9	2.2	5.7	-2.4	-0.4	-0.8
Respiratory disease	0.8	1.8	3.9	-2.0	1.1	-0.1
Type 2 Diabetes (T2D) (2018)	2.6	4.9	11.6	-3.4	-0.8	-1.6
Lung FEV1/FVC ratio	0.2	1.0	2.5	-0.6	0.4	-1.6
Lung FVC	0.0	0.2	0.4	0.4	0.6	0.2
Neuroticism	0.5	1.2	2.6	-1.6	0.8	0.6
Chronotype (morning person)	0.5	1.2	3.5	-0.3	1.9	-0.1
Hair Pigment	0.0	0.4	0.8	-0.9	-0.5	-0.4
Tanning	0.2	2.7	7.1	1.0	0.2	2.7
Hand grip strength (left)	0.8	2.2	5.0	-2.2	0.9	-0.9
Number of treatments/medications taken	4.0	7.3	13.1	-2.9	-3.6	-0.6
Average weekly spirits intake	2.5	3.2	5.9	0.2	-1.9	-2.4
Sensitivity / hurt feelings	0.3	0.6	0.8	0.8	0.9	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	-0.1	-0.4	0.7
Hearing difficulty/problems: Yes	1.1	1.7	4.9	0.4	2.2	-0.2
Relative age of first facial hair	0.2	0.3	0.6	0.8	0.1	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.2	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.7	1.3	-0.5	0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.0	1.0	0.9	-0.1
Systolic blood pressure, automated reading	1.0	2.8	7.0	-1.2	-2.6	0.3
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	7.1	-2.7	-0.8	-1.2
Angina	1.2	1.5	4.5	-0.2	-2.1	-0.0
Medication for hormone replacement therapy	1.2	1.4	3.1	0.7	-0.7	-1.8
Vitamin and mineral supplements	0.6	0.8	1.1	-0.4	-1.0	1.1
Supplements: Zinc	0.5	0.6	1.2	-0.4	0.7	-1.1
Medication: Co-codamol	1.9	2.2	4.0	-2.0	-1.6	0.0
Medication: Metformin	1.1	1.5	2.3	-0.8	-1.2	-1.5
Diabetes (father)	0.8	0.9	2.5	0.0	-1.6	0.6
Diabetes (mother)	2.1	2.7	6.1	0.1	2.5	-1.4
Severe depression (siblings)	0.4	0.4	0.8	-0.9	-0.5	0.5
Pack years adult smoking proportion	0.8	1.2	2.3	-1.5	-0.3	-1.1
Impedance of leg (right)	0.0	0.2	0.5	0.1	-0.3	0.7
Leg fat-free mass (left)	0.3	1.8	4.3	-2.1	-1.1	-0.1
Trunk fat percentage	0.1	0.4	1.3	0.2	-1.1	0.2
Hand grip strength (right)	0.8	2.1	4.2	-2.0	1.5	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.7	0.3	0.1
Current tobacco smoking	0.2	0.3	0.7	-0.8	-0.1	0.2
Average weekly fortified wine intake	0.3	0.3	0.6	0.4	-0.5	-0.7
Maternal smoking around birth	0.0	0.1	0.1	0.3	0.3	0.1
Fed-up feelings	0.4	0.8	2.0	0.1	1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.6	-0.3	-0.1
Relative age voice broke	0.4	0.6	0.9	0.8	-0.9	-0.6
Taking other prescription medications	3.2	4.9	8.0	-2.8	-2.5	0.6
Age when periods started (menarche)	0.7	1.6	4.4	0.2	-0.7	-2.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.0	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	0.5	-0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.2	-0.4	0.4	-0.5
Qualifications: CSEs or equivalent	0.9	1.2	3.3	-0.3	1.8	-0.3
Serious illness, injury or assault to yourself	0.8	1.0	2.0	-1.4	-0.7	-0.6
High blood pressure	1.2	3.2	4.4	-2.1	-2.1	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	-0.6	0.8	-0.0
Multivitamins +/- minerals	0.3	0.4	1.0	-0.4	1.0	-0.0
Stomach or abdominal pain in last month	0.5	0.7	2.0	-1.4	0.0	0.1
Supplements: Glucosamine	1.5	1.9	3.4	1.2	-1.8	-0.9
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.3	-1.1	2.1	-0.4
Medication: Atenolol	2.0	2.5	6.5	-2.5	-0.9	-0.4
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.1	-0.3	-0.8
Sitting height	0.1	0.8	1.9	-1.4	-0.7	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	0.2	0.1
High blood pressure (mother)	0.2	0.3	0.3	-0.5	0.5	-0.5
Body mass index (BMI)	0.1	0.5	1.0	0.0	-0.7	-1.0
Impedance of leg (left)	0.1	0.4	1.0	0.5	-0.4	1.0
Leg predicted mass (left)	0.4	1.9	4.5	-2.1	-1.0	-0.2
Trunk fat mass	0.2	0.8	2.0	-0.6	-1.4	0.1
Waist circumference	0.4	1.5	2.2	-1.4	-1.5	-0.4
Number of incorrect matches in round	0.5	0.8	1.6	0.6	1.3	-0.8
Past tobacco smoking	0.9	1.6	4.4	-0.5	2.1	0.4
Alcohol usually taken with meals	0.2	0.3	0.5	-0.5	-0.7	-0.5
Nervous feelings	0.8	1.4	3.8	-0.5	0.4	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.1	-1.1	-0.5	0.8
Hearing difficulty/problems with background noise	0.3	0.4	0.5	0.7	0.7	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	0.0	0.4
Had menopause	0.6	0.7	1.6	0.2	-0.8	1.3
Had other major operations	1.1	1.3	3.5	0.5	-1.9	0.4
Forced vital capacity (FVC)	0.3	1.2	2.9	-1.7	-0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.6	0.7	-0.1	1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.4	-0.4	0.8
Qualifications: None of the above	0.5	1.2	3.3	0.4	0.1	-1.8
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.5	0.1	-0.6
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	0.4	0.1
Heart attack	0.7	0.9	1.7	0.2	-0.9	1.3
Allergy	0.5	1.0	2.9	1.7	-0.1	0.5
Pain all over the body in last month	0.9	0.9	2.1	0.8	-1.4	0.2
Diabetes (self-reported)	2.2	3.4	7.6	-2.8	-1.0	-1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	-0.4	-1.1	1.4
Medication: Ramipril	0.7	0.9	2.0	-0.5	-1.4	-0.7
Medication: Simvastatin	0.9	1.3	2.3	-0.5	-1.5	-1.2
Fluid intelligence score	0.4	0.7	1.5	-0.7	-0.4	1.2
Illnesses of siblings	0.4	0.6	0.7	0.9	0.5	0.8
Neuroticism score	0.3	0.7	1.1	-0.7	0.7	1.0
Weight	0.3	1.5	2.6	-1.6	-1.4	-0.3
Impedance of arm (right)	0.1	0.3	0.9	-0.3	-0.1	1.0
Arm fat percentage (right)	0.1	0.3	0.3	0.4	-0.6	-0.6
Trunk fat-free mass	0.6	3.6	8.8	-3.0	-1.4	-0.1
Hip circumference	0.1	0.5	0.9	-0.9	-0.8	0.1
Time employed in main current job	0.5	0.6	1.2	-0.8	-1.1	-0.1
Alcohol intake versus 10 years previously	0.9	1.4	2.3	1.5	-0.5	-1.3
Father’s age at death	0.4	0.5	1.1	-0.2	-1.1	-0.6
Worrier / anxious feelings	0.3	0.6	1.2	0.7	0.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.1	-0.2	0.0
Falls in the last year	0.5	0.7	2.0	0.0	0.1	-1.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	-0.7	0.5	-1.2
Number of live births	1.0	1.4	3.2	-0.9	-1.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.7	-1.3	-0.6	-0.6
Pulse rate	0.5	0.8	2.5	-0.1	1.6	-0.1
Happiness	1.4	1.7	4.2	0.1	-0.9	2.0
Noisy workplace	2.3	2.9	4.4	2.1	1.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.7	1.7	3.0	-1.7	-0.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	0.7	0.6	0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	1.2	-0.5	0.3
Asthma	0.7	1.5	3.9	-2.0	-0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.7	1.3	-0.3	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.3	-0.5	-0.1	-1.2
Depression (self-reported)	1.3	1.6	4.2	-2.0	-0.4	0.7
Medication: Lansoprazole	3.0	3.4	6.3	-1.8	-2.5	-0.7
Prospective memory result	0.9	1.1	2.0	-1.1	-1.4	-0.6
Lung cancer (father)	0.2	0.3	0.8	0.0	0.9	-0.0
Illnesses of mother	0.3	0.4	0.9	-0.6	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.4	-1.5	-0.7	-1.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.1	-0.8	0.5
Impedance of arm (left)	0.2	0.8	1.8	0.7	-0.0	1.4
Arm fat mass (right)	0.2	0.7	1.3	-0.5	-1.1	-0.6
Trunk predicted mass	0.6	3.5	8.8	-3.0	-1.3	-0.2
Standing height	0.6	6.0	14.4	-3.8	-1.6	1.0
Length of working week for main job	0.7	0.7	1.4	-1.2	-0.6	-0.7
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.1	-0.3	-0.4
Breastfed as a baby	1.2	1.5	3.4	-1.8	-1.0	0.1
Tense / ‘highly strung’	0.7	1.2	2.5	-1.6	0.3	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	-0.6	0.3
Hair/balding pattern: Pattern 4	0.6	1.5	2.7	-1.6	0.9	0.9
Birth weight of first child	5.2	9.4	19.0	0.7	4.4	3.0
Peak expiratory flow (PEF)	0.5	1.1	2.5	-0.2	-0.8	-1.6
Pulse wave reflection index	1.4	1.8	5.0	-0.4	-2.2	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.8	0.3	0.3
Loud music exposure frequency	2.0	2.2	5.8	-0.5	0.7	2.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.5	-0.6	-1.3	1.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.1	-1.4	-1.4	-0.7
Blood clot in the leg (DVT)	1.9	2.5	6.6	-2.6	0.9	0.3
Medication: Paracetamol	0.8	1.4	2.0	-1.0	-1.4	1.1
Headache pain in last month	0.3	0.6	1.1	-0.7	0.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.2	1.1	0.1	0.2
Glaucoma (self-reported)	0.5	0.5	1.4	-0.1	1.2	-0.4
Gout (self-reported)	1.8	2.5	2.9	-1.5	1.5	-1.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.3	-1.8	-0.8	-0.6
Medication: Amlodipine	0.6	0.8	2.1	0.4	-0.6	1.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.0	-0.9	-0.2
Birth weight	1.4	3.0	4.2	2.0	1.8	1.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	0.2	0.2	0.6
High blood pressure (siblings)	0.4	0.6	0.9	-0.1	0.9	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.3	3.0	-1.7	-0.6	-0.7
Body fat percentage	0.1	0.4	1.1	0.4	-1.1	-0.1
Leg fat percentage (right)	0.2	0.6	1.5	1.2	-0.6	-0.0
Arm fat-free mass (right)	0.5	2.5	4.4	-2.1	-1.7	-0.0
Exposure to tobacco smoke outside home	0.6	0.8	1.0	0.8	0.9	1.0
Comparative body size at age 10	0.9	2.4	5.0	2.2	1.5	-0.3
Number of full brothers	0.5	0.6	0.9	-0.9	-0.5	-0.9
Worry too long after embarrassment	1.9	3.2	7.0	1.4	-0.7	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.9	-0.2	0.2
Wheeze or whistling in the chest in last year	1.6	2.9	8.5	-2.9	-0.4	-0.3
Number of children fathered	1.2	1.4	3.2	1.8	0.9	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	-1.1	1.2	-1.6
Age at first live birth	0.2	0.4	1.1	0.3	-0.3	1.0
Pulse wave peak to peak time	0.1	0.2	0.3	-0.3	0.6	-0.2
Health satisfaction	0.3	0.4	0.7	0.1	0.6	-0.8
Shortness of breath walking on level ground	1.5	1.7	5.0	-0.5	-0.0	-2.2
Qualifications: College or University degree	0.2	0.7	1.5	-0.1	0.7	-1.2
Eye problems/disorders: None of the above	0.4	0.4	1.2	0.2	-0.0	1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.5	0.8	1.2	1.0
Emphysema/chronic bronchitis	2.2	2.5	5.4	-0.7	1.3	-2.3
Medication for pain relief, constipation, heartburn	1.5	2.6	5.3	2.3	1.6	-0.1
Neck or shoulder pain in last month	1.4	2.0	4.8	-2.2	-0.7	-0.8
Medication: Blood pressure	0.3	0.6	1.7	-1.3	-0.1	0.0
Angina (self-reported)	0.9	1.2	3.5	-0.1	-1.9	0.1
Migraine (self-reported)	0.5	0.6	1.0	-0.5	-0.7	1.0
Medication: Ibuprofen	0.8	0.9	2.8	1.7	0.0	-0.1
Medication: Allopurinol	0.9	1.1	1.8	-1.4	0.3	-1.2
Medication: Omeprazole	2.4	2.8	4.5	-2.1	-1.0	-1.7
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.4	-0.2	0.6
Mean time to correctly identify matches	0.9	1.7	2.5	1.4	-1.6	0.7
Heart disease (mother)	0.6	0.7	1.9	-0.5	0.1	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.4	-1.2	-0.0
Whole body fat mass	0.2	0.8	2.0	-0.5	-1.4	-0.1
Leg fat mass (right)	0.1	0.4	1.0	-0.1	-1.0	-0.4
Arm predicted mass (right)	0.5	2.6	4.4	-2.1	-1.8	0.2
Pulse rate, automated reading	0.2	0.6	1.2	-1.1	0.1	-0.9
Alcohol intake frequency.	0.6	1.4	2.9	-1.7	-0.9	-0.5
Comparative height size at age 10	0.4	2.4	4.9	-2.2	-1.5	0.0
Number of full sisters	1.3	1.5	2.3	-1.2	1.5	1.0
Suffer from ‘nerves’	0.7	1.1	2.4	-0.9	-0.2	1.5
Overall health rating	0.3	0.5	1.5	-0.0	-1.2	-0.3
Chest pain or discomfort	0.8	1.2	3.3	-0.4	0.1	1.8
Had major operations	0.1	0.1	0.2	0.1	-0.4	0.4
Age at last live birth	2.1	3.1	7.2	-2.7	-1.4	-0.6
Family relationship satisfaction	0.7	0.8	1.3	0.7	-0.8	1.2
Leg pain on walking	1.5	1.9	3.0	-1.0	-1.3	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.3	1.5	-0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.8	-0.8	-1.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.2	0.0	0.7
Medication: Aspirin	0.2	0.2	0.3	-0.5	0.1	-0.5
Supplements: Vitamin C	0.7	0.8	1.8	0.4	0.6	-1.3
Knee pain experienced in last month	1.1	1.7	3.9	-0.9	-2.0	-0.6
Hypertension (Self-reported)	1.3	3.6	5.8	-1.9	-2.4	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	-1.6	-0.6	-0.2
Illnesses of father: Heart disease	2.1	3.0	8.2	0.8	-2.9	-0.0
Illnesses of siblings: Diabetes	2.4	3.0	7.8	-1.0	-2.8	0.5
Smoking status: Previous	0.8	1.3	2.9	0.2	-1.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.5	-1.2	-1.2	-0.4
Whole body fat-free mass	0.5	3.0	7.1	-2.7	-1.4	-0.2
Leg fat-free mass (right)	0.4	2.0	4.7	-2.2	-1.1	-0.0
Arm fat percentage (left)	0.1	0.4	0.7	0.8	-0.6	-0.4
Average weekly red wine intake	0.1	0.1	0.3	-0.2	0.5	-0.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.5	-0.0	1.9	-0.5
Mood swings	0.3	0.5	0.8	0.5	0.6	0.9
Loneliness, isolation	0.8	1.1	2.2	-0.5	1.0	1.5
Long-standing illness, disability or infirmity	2.5	3.8	5.7	-2.2	-1.0	-2.4
Ever had bowel cancer screening	0.1	0.1	0.4	-0.2	-0.1	-0.6
Diabetes diagnosed by doctor	2.5	4.2	8.5	-2.9	-1.7	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.4	-0.3	-2.1	0.2
Friendships satisfaction	0.4	0.5	1.1	0.3	0.6	1.1
Qualifications: nursing, teaching	0.2	0.2	0.6	0.3	-0.2	0.8
Commuting to job workplace: Walk	0.3	0.3	0.5	0.2	-0.6	-0.7
Eye problems/disorders: Cataract	2.8	3.2	7.9	0.5	2.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	0.9	-0.8	1.0	-1.0
Medication for cholesterol	4.3	6.5	12.4	1.1	3.5	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.4	0.7	-0.6
Back pain experienced in last month	0.8	1.1	3.0	-0.5	1.7	-0.4
Mineral and other dietary supplements	0.7	0.9	1.4	-1.2	0.5	1.0
Breast cancer (self-reported)	0.4	0.5	1.5	-1.2	0.1	0.4
Asthma (self-reported)	0.6	1.2	3.3	-1.8	-0.3	0.5
Osteoporosis (self-reported)	0.7	0.8	1.3	1.1	1.0	-0.5
Osteoarthritis (self-reported)	3.4	4.4	12.8	-0.2	-3.6	-0.7
Medication: Aspirin	0.1	0.1	0.2	-0.5	-0.2	0.2
Medication: Gliclazide	1.0	1.1	2.6	-1.6	-0.8	-0.4
Illnesses of father: None of the above (group 1)	2.7	3.3	7.0	-1.4	2.7	0.9
Smoking status: Current	0.2	0.2	0.3	-0.6	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.0	0.0	-0.2
Whole body water mass	0.6	3.1	7.4	-2.7	-1.4	-0.1
Leg predicted mass (right)	0.4	2.1	5.2	-2.3	-1.1	-0.1
Arm fat mass (left)	0.1	0.6	1.4	-0.5	-1.2	-0.4
Number of self-reported non-cancer illnesses	2.1	3.7	6.5	-2.1	-2.5	0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.1	-0.8	-0.4
Miserableness	0.4	0.7	1.1	-1.0	1.0	0.0
Guilty feelings	0.8	1.1	3.2	-0.1	0.5	1.8
Wears glasses or contact lenses	0.7	0.8	1.3	0.8	-1.1	0.7
Ever taken oral contraceptive pill	1.1	1.2	1.9	1.2	1.4	0.3
Hearing aid user	0.5	0.6	0.9	0.2	0.9	-1.0
Mother’s age at death	1.2	1.5	4.5	-2.1	-0.0	0.0
Financial situation satisfaction	0.3	0.4	1.0	0.2	-0.3	1.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.6	0.0	-0.8	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	0.4	-0.5
Eye problems/disorders: Glaucoma	0.8	1.0	2.7	0.5	1.6	0.1
Medication: Blood pressure	2.2	4.2	10.8	-1.2	-3.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	0.6	1.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.7	0.4	-0.5
High cholesterol (Self-reported)	2.1	3.7	10.8	0.1	-0.4	-3.3
Medication: Bendroflumethiazide	0.4	0.6	0.9	-0.6	-1.0	0.7
Medication: Paracetamol	0.8	1.2	3.4	-0.5	-1.9	0.2
Medication: Lisinopril	0.8	1.1	2.5	-1.6	-0.8	0.4
Medication: Atorvastatin	0.6	0.7	1.1	-1.0	-0.4	-1.0
Illnesses of father: High blood pressure	1.5	1.9	4.5	2.1	-0.5	-1.0
Alcohol drinker status: Never	0.8	0.9	1.9	-1.4	-0.9	-0.0
Ever smoked	0.9	1.6	4.0	-0.8	-2.0	-0.1
Basal metabolic rate	0.5	2.9	6.5	-2.5	-1.5	-0.1
Leg fat percentage (left)	0.2	0.8	1.9	1.4	-0.7	0.2
Arm fat-free mass (left)	0.6	2.9	6.2	-2.5	-1.5	0.1
Number of operations (self-reported)	1.1	1.7	4.2	-0.6	-2.0	0.8
Average weekly beer plus cider intake	1.0	1.5	2.4	-1.4	-0.0	1.6
Irritability	0.2	0.4	0.8	-0.1	0.6	-0.9
Risk taking	0.7	1.0	1.8	-1.0	1.3	0.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.5	-0.7	0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.9	-0.2	1.4	0.1
Age started oral contraceptive pill	0.6	0.7	1.8	0.4	-1.3	0.4
Diastolic blood pressure, automated reading	0.1	0.4	1.2	-1.1	0.4	0.1
Ever depressed for a whole week	0.2	0.3	0.5	-0.5	0.2	0.7
Unable to work because of sickness or disability	0.7	1.0	2.2	-1.5	-0.8	0.1
Commuting to job workplace: Cycle	0.8	1.0	1.8	1.3	0.7	0.8
Myopia	0.5	0.7	2.1	-0.0	-1.5	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.3	5.5	2.0	2.3	0.7
Cholesterol lowering medication	3.8	5.6	10.5	-1.3	-3.2	-2.1
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	5.7	-2.4	-1.0	-1.9
Pain experienced in last month	1.1	1.8	3.1	1.8	1.4	0.7
Supplements: Calcium	0.9	1.0	2.1	1.4	0.9	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	0.7	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	0.3	-0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	5.4	-2.3	1.0	0.4
Heart disease (siblings)	0.7	0.9	2.3	-0.7	-1.5	0.1
Alcohol drinker status: Previous	0.7	0.8	1.9	-0.6	1.4	-0.2
Pack years of smoking	0.9	1.3	3.1	-1.8	-0.4	-0.7
Impedance of whole body	0.2	1.0	2.2	0.9	0.0	1.5
Leg fat mass (left)	0.1	0.4	1.2	-0.1	-1.1	-0.3
Arm predicted mass (left)	0.6	2.9	5.7	-2.4	-1.7	0.1